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Patent code US9920060

Compile Data Set for Download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376962
PNG
(US10329300, Example 50 | US9920060, 50)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1F
Show InChI InChI=1S/C24H26ClFN8O3/c1-4-16(35)33-9-5-6-14(11-33)34-23-18(22(27)28-12-29-23)21(31-34)24(37)30-15-8-7-13(20(26)19(15)25)10-17(36)32(2)3/h4,7-8,12,14H,1,5-6,9-11H2,2-3H3,(H,30,37)(H2,27,28,29)/t14-/m1/s1
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n/an/a 2.90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376933
PNG
(US10329300, Example 27 | US9920060, 27)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1
Show InChI InChI=1S/C23H25ClN8O4/c1-4-17(33)31-9-5-6-13(11-31)32-21-18(20(25)26-12-27-21)19(29-32)22(34)28-16-8-7-14(10-15(16)24)36-23(35)30(2)3/h4,7-8,10,12-13H,1,5-6,9,11H2,2-3H3,(H,28,34)(H2,25,26,27)/t13-/m1/s1
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n/an/a 3.90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376912
PNG
(US10329300, Example 6 | US9920060, 6)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1
Show InChI InChI=1S/C24H27ClN8O3/c1-4-18(34)32-9-5-6-15(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(36)29-17-8-7-14(10-16(17)25)11-19(35)31(2)3/h4,7-8,10,13,15H,1,5-6,9,11-12H2,2-3H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376924
PNG
(US10329300, Example 18 | US9920060, 18)
Show SMILES CN(C)C(=O)Cc1cc(Cl)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1F
Show InChI InChI=1S/C24H26ClFN8O3/c1-4-18(35)33-7-5-6-14(11-33)34-23-20(22(27)28-12-29-23)21(31-34)24(37)30-17-10-16(26)13(8-15(17)25)9-19(36)32(2)3/h4,8,10,12,14H,1,5-7,9,11H2,2-3H3,(H,30,37)(H2,27,28,29)/t14-/m1/s1
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n/an/a 4.40n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376920
PNG
(US10329300, Example 14 | US9920060, 14)
Show SMILES COc1c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc(CC(=O)N(C)C)c1F
Show InChI InChI=1S/C25H29FN8O4/c1-5-17(35)33-10-6-7-15(12-33)34-24-19(23(27)28-13-29-24)21(31-34)25(37)30-16-9-8-14(11-18(36)32(2)3)20(26)22(16)38-4/h5,8-9,13,15H,1,6-7,10-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t15-/m1/s1
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n/an/a 4.60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376988
PNG
(US10329300, Example 76 | US9920060, 76)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CC(F)CN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1
Show InChI InChI=1S/C24H26ClFN8O3/c1-4-18(35)33-10-14(26)9-15(11-33)34-23-20(22(27)28-12-29-23)21(31-34)24(37)30-17-6-5-13(7-16(17)25)8-19(36)32(2)3/h4-7,12,14-15H,1,8-11H2,2-3H3,(H,30,37)(H2,27,28,29)/t14?,15-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376948
PNG
(US10329300, Example 36 | US9920060, 36)
Show SMILES COc1cc(OC(=O)N(C)C)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C24H28N8O5/c1-5-18(33)31-10-6-7-14(12-31)32-22-19(21(25)26-13-27-22)20(29-32)23(34)28-16-9-8-15(11-17(16)36-4)37-24(35)30(2)3/h5,8-9,11,13-14H,1,6-7,10,12H2,2-4H3,(H,28,34)(H2,25,26,27)/t14-/m1/s1
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n/an/a 5.40n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376923
PNG
(US10329300, Example 17 | US9920060, 17)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Br)c1
Show InChI InChI=1S/C24H27BrN8O3/c1-4-18(34)32-9-5-6-15(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(36)29-17-8-7-14(10-16(17)25)11-19(35)31(2)3/h4,7-8,10,13,15H,1,5-6,9,11-12H2,2-3H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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n/an/a 5.90n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376945
PNG
((R)-4-(1-(1-acryloylpiperidin-3-yl)-4-amino-1H-pyr...)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ccccc12
Show InChI InChI=1S/C27H28N8O4/c1-4-21(36)34-13-7-8-16(14-34)35-25-22(24(28)29-15-30-25)23(32-35)26(37)31-19-11-12-20(39-27(38)33(2)3)18-10-6-5-9-17(18)19/h4-6,9-12,15-16H,1,7-8,13-14H2,2-3H3,(H,31,37)(H2,28,29,30)/t16-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376941
PNG
(US10329300, Example 29 | US9920060, 29)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C23H25ClN8O4/c1-4-17(33)31-9-5-6-14(11-31)32-21-18(20(25)26-12-27-21)19(29-32)22(34)28-13-7-8-16(15(24)10-13)36-23(35)30(2)3/h4,7-8,10,12,14H,1,5-6,9,11H2,2-3H3,(H,28,34)(H2,25,26,27)/t14-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376932
PNG
(US10329300, Example 26 | US9920060, 26)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C24H28N8O4/c1-5-18(33)31-10-6-7-15(12-31)32-22-19(21(25)26-13-27-22)20(29-32)23(34)28-17-9-8-16(11-14(17)2)36-24(35)30(3)4/h5,8-9,11,13,15H,1,6-7,10,12H2,2-4H3,(H,28,34)(H2,25,26,27)/t15-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376913
PNG
(US10329300, Example 7 | US9920060, 7)
Show SMILES COc1cc(CC(=O)N(C)C)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C25H30N8O4/c1-5-19(34)32-10-6-7-16(13-32)33-24-21(23(26)27-14-28-24)22(30-33)25(36)29-17-9-8-15(11-18(17)37-4)12-20(35)31(2)3/h5,8-9,11,14,16H,1,6-7,10,12-13H2,2-4H3,(H,29,36)(H2,26,27,28)/t16-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376909
PNG
(US10329300, Example 3 | US9920060, 3)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1C
Show InChI InChI=1S/C25H29ClN8O3/c1-5-18(35)33-10-6-7-16(12-33)34-24-20(23(27)28-13-29-24)22(31-34)25(37)30-17-9-8-15(14(2)21(17)26)11-19(36)32(3)4/h5,8-9,13,16H,1,6-7,10-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376917
PNG
(US10329300, Example 11 | US9920060, 11)
Show SMILES COc1c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc(CC(=O)N(C)C)c1Cl
Show InChI InChI=1S/C25H29ClN8O4/c1-5-17(35)33-10-6-7-15(12-33)34-24-19(23(27)28-13-29-24)21(31-34)25(37)30-16-9-8-14(11-18(36)32(2)3)20(26)22(16)38-4/h5,8-9,13,15H,1,6-7,10-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t15-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376918
PNG
(US10329300, Example 12 | US9920060, 12)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1F
Show InChI InChI=1S/C25H29FN8O3/c1-5-18(35)33-10-6-7-16(12-33)34-24-20(23(27)28-13-29-24)22(31-34)25(37)30-17-9-8-15(21(26)14(17)2)11-19(36)32(3)4/h5,8-9,13,16H,1,6-7,10-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376980
PNG
((R)-4-(1-(1-acryloylpyrimidin-3-yl)-4-amino-1H-pyr...)
Show SMILES CN(C(=O)Oc1ccc(NC(=O)c2nn(N3CN(CC=C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1)c1ccccc1
Show InChI InChI=1S/C28H27N9O4/c1-4-22(38)35-13-8-14-36(17-35)37-26-23(25(29)30-16-31-26)24(33-37)27(39)32-21-12-11-20(15-18(21)2)41-28(40)34(3)19-9-6-5-7-10-19/h4-12,14-16H,1,13,17H2,2-3H3,(H,32,39)(H2,29,30,31)
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n/an/a 7.70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376908
PNG
(US10329300, Example 2 | US9920060, 2)
Show SMILES CN(C)C(=O)Cc1cc(Cl)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C25H29ClN8O3/c1-5-19(35)33-8-6-7-16(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-18-9-14(2)15(10-17(18)26)11-20(36)32(3)4/h5,9-10,13,16H,1,6-8,11-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376960
PNG
(US10329300, Example 48 | US9920060, 48)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C=C)c1
Show InChI InChI=1S/C26H30N8O3/c1-5-17-12-16(13-21(36)32(3)4)9-10-19(17)30-26(37)23-22-24(27)28-15-29-25(22)34(31-23)18-8-7-11-33(14-18)20(35)6-2/h5-6,9-10,12,15,18H,1-2,7-8,11,13-14H2,3-4H3,(H,30,37)(H2,27,28,29)/t18-/m1/s1
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n/an/a 8.5n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376921
PNG
(US10329300, Example 15 | US9920060, 15)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(OC(F)F)c1
Show InChI InChI=1S/C25H28F2N8O4/c1-4-18(36)34-9-5-6-15(12-34)35-23-20(22(28)29-13-30-23)21(32-35)24(38)31-16-8-7-14(11-19(37)33(2)3)10-17(16)39-25(26)27/h4,7-8,10,13,15,25H,1,5-6,9,11-12H2,2-3H3,(H,31,38)(H2,28,29,30)/t15-/m1/s1
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n/an/a 8.60n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376942
PNG
(US10329300, Example 30 | US9920060, 30)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C24H28N8O4/c1-5-18(33)31-10-6-7-16(12-31)32-22-19(21(25)26-13-27-22)20(29-32)23(34)28-15-8-9-17(14(2)11-15)36-24(35)30(3)4/h5,8-9,11,13,16H,1,6-7,10,12H2,2-4H3,(H,28,34)(H2,25,26,27)/t16-/m1/s1
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n/an/a 8.70n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376981
PNG
(US9920060, 69)
Show SMILES Cc1cc(OC(=O)N2CCCC2)ccc1NC(=O)c1nn(N2CC=CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C25H27N9O4/c1-3-19(35)32-11-6-12-33(15-32)34-23-20(22(26)27-14-28-23)21(30-34)24(36)29-18-8-7-17(13-16(18)2)38-25(37)31-9-4-5-10-31/h3,6-8,11,13-14H,1,4-5,9-10,12,15H2,2H3,(H,29,36)(H2,26,27,28)
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376914
PNG
(US10329300, Example 8 | US9920060, 8)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C24H27ClN8O3/c1-4-18(34)32-9-5-6-16(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(36)29-15-8-7-14(17(25)11-15)10-19(35)31(2)3/h4,7-8,11,13,16H,1,5-6,9-10,12H2,2-3H3,(H,29,36)(H2,26,27,28)/t16-/m1/s1
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n/an/a 9.20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376944
PNG
(US10329300, Example 32 | US9920060, 32)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C
Show InChI InChI=1S/C25H30N8O4/c1-6-19(34)32-11-7-8-16(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(35)29-17-9-10-18(15(3)14(17)2)37-25(36)31(4)5/h6,9-10,13,16H,1,7-8,11-12H2,2-5H3,(H,29,35)(H2,26,27,28)/t16-/m1/s1
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n/an/a 9.30n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376982
PNG
(US9920060, 70)
Show SMILES Cc1cc(OC(=O)N2CCCCC2)ccc1NC(=O)c1nn(N2CC=CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C26H29N9O4/c1-3-20(36)33-12-7-13-34(16-33)35-24-21(23(27)28-15-29-24)22(31-35)25(37)30-19-9-8-18(14-17(19)2)39-26(38)32-10-5-4-6-11-32/h3,7-9,12,14-15H,1,4-6,10-11,13,16H2,2H3,(H,30,37)(H2,27,28,29)
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376922
PNG
(US10329300, Example 16 | US9920060, 16)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(OCF)c1
Show InChI InChI=1S/C25H29FN8O4/c1-4-19(35)33-9-5-6-16(12-33)34-24-21(23(27)28-14-29-24)22(31-34)25(37)30-17-8-7-15(10-18(17)38-13-26)11-20(36)32(2)3/h4,7-8,10,14,16H,1,5-6,9,11-13H2,2-3H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376950
PNG
(US10329300, Example 38 | US9920060, 38)
Show SMILES CN(C)C(=O)Oc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C25H30N8O4/c1-6-19(34)32-9-7-8-16(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(35)29-17-10-15(3)18(11-14(17)2)37-25(36)31(4)5/h6,10-11,13,16H,1,7-9,12H2,2-5H3,(H,29,35)(H2,26,27,28)/t16-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376915
PNG
(US10329300, Example 9 | US9920060, 9)
Show SMILES COc1cc(CC(=O)N(C)C)c(Cl)cc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C25H29ClN8O4/c1-5-19(35)33-8-6-7-15(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-17-11-16(26)14(9-18(17)38-4)10-20(36)32(2)3/h5,9,11,13,15H,1,6-8,10,12H2,2-4H3,(H,30,37)(H2,27,28,29)/t15-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376907
PNG
(US10329300, Example 1 | US9920060, 1)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Br
Show InChI InChI=1S/C25H29BrN8O3/c1-5-19(35)33-8-6-7-16(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-18-11-17(26)15(9-14(18)2)10-20(36)32(3)4/h5,9,11,13,16H,1,6-8,10,12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376925
PNG
(US10329300, Example 19 | US9920060, 19)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C25H29ClN8O3/c1-5-19(35)33-8-6-7-16(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-18-11-17(26)15(9-14(18)2)10-20(36)32(3)4/h5,9,11,13,16H,1,6-8,10,12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376970
PNG
((R)-4-(1-(1-acryloylpyrrolidin-3-yl)-4-amino-1H-py...)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ccccc12
Show InChI InChI=1S/C26H26N8O4/c1-4-20(35)33-12-11-15(13-33)34-24-21(23(27)28-14-29-24)22(31-34)25(36)30-18-9-10-19(38-26(37)32(2)3)17-8-6-5-7-16(17)18/h4-10,14-15H,1,11-13H2,2-3H3,(H,30,36)(H2,27,28,29)/t15-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376983
PNG
(US10329300, Example 71 | US9920060, 71)
Show SMILES Cc1cc(CC(=O)N2CCCC2)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C27H32N8O3/c1-3-21(36)34-12-6-7-19(15-34)35-26-23(25(28)29-16-30-26)24(32-35)27(38)31-20-9-8-18(13-17(20)2)14-22(37)33-10-4-5-11-33/h3,8-9,13,16,19H,1,4-7,10-12,14-15H2,2H3,(H,31,38)(H2,28,29,30)/t19-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376911
PNG
(US10329300, Example 5 | US9920060, 5)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ccccc12
Show InChI InChI=1S/C28H30N8O3/c1-4-22(37)35-13-7-8-18(15-35)36-27-24(26(29)30-16-31-27)25(33-36)28(39)32-21-12-11-17(14-23(38)34(2)3)19-9-5-6-10-20(19)21/h4-6,9-12,16,18H,1,7-8,13-15H2,2-3H3,(H,32,39)(H2,29,30,31)/t18-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376946
PNG
(US10329300, Example 34 | US9920060, 34)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1F
Show InChI InChI=1S/C23H25FN8O4/c1-4-17(33)31-9-5-6-14(11-31)32-21-18(20(25)26-12-27-21)19(29-32)22(34)28-13-7-8-16(15(24)10-13)36-23(35)30(2)3/h4,7-8,10,12,14H,1,5-6,9,11H2,2-3H3,(H,28,34)(H2,25,26,27)/t14-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376949
PNG
(US10329300, Example 37 | US9920060, 37)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ncccc12
Show InChI InChI=1S/C26H27N9O4/c1-4-19(36)34-12-6-7-15(13-34)35-24-20(23(27)29-14-30-24)22(32-35)25(37)31-17-9-10-18(39-26(38)33(2)3)16-8-5-11-28-21(16)17/h4-5,8-11,14-15H,1,6-7,12-13H2,2-3H3,(H,31,37)(H2,27,29,30)/t15-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376984
PNG
(US9920060, 72)
Show SMILES CN[C@@H](C(=O)OC)c1ccc(NC(=O)c2nn(C3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C25H30N8O4/c1-5-18(34)32-10-6-7-16(12-32)33-23-19(22(26)28-13-29-23)21(31-33)24(35)30-17-9-8-15(11-14(17)2)20(27-3)25(36)37-4/h5,8-9,11,13,16,20,27H,1,6-7,10,12H2,2-4H3,(H,30,35)(H2,26,28,29)/t16?,20-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376910
PNG
(US10329300, Example 4 | US9920060, 4)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C25H30N8O3/c1-5-19(34)32-10-6-7-17(13-32)33-24-21(23(26)27-14-28-24)22(30-33)25(36)29-18-9-8-16(11-15(18)2)12-20(35)31(3)4/h5,8-9,11,14,17H,1,6-7,10,12-13H2,2-4H3,(H,29,36)(H2,26,27,28)/t17-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376919
PNG
(US10329300, Example 13 | US9920060, 13)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C
Show InChI InChI=1S/C26H32N8O3/c1-6-20(35)33-11-7-8-18(13-33)34-25-22(24(27)28-14-29-25)23(31-34)26(37)30-19-10-9-17(15(2)16(19)3)12-21(36)32(4)5/h6,9-10,14,18H,1,7-8,11-13H2,2-5H3,(H,30,37)(H2,27,28,29)/t18-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376973
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-4-amino-N-(4-(2-...)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ccccc12
Show InChI InChI=1S/C27H28N8O3/c1-4-21(36)34-12-11-17(14-34)35-26-23(25(28)29-15-30-26)24(32-35)27(38)31-20-10-9-16(13-22(37)33(2)3)18-7-5-6-8-19(18)20/h4-10,15,17H,1,11-14H2,2-3H3,(H,31,38)(H2,28,29,30)/t17-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376989
PNG
(US10329300, Example 77 | US9920060, 77)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CC(F)CN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C
Show InChI InChI=1S/C26H31FN8O3/c1-6-20(36)34-11-17(27)10-18(12-34)35-25-22(24(28)29-13-30-25)23(32-35)26(38)31-19-8-7-16(14(2)15(19)3)9-21(37)33(4)5/h6-8,13,17-18H,1,9-12H2,2-5H3,(H,31,38)(H2,28,29,30)/t17?,18-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376964
PNG
(US10329300, Example 52 | US9920060, 52)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(c1)-c1ccoc1
Show InChI InChI=1S/C28H30N8O4/c1-4-22(37)35-10-5-6-19(14-35)36-27-24(26(29)30-16-31-27)25(33-36)28(39)32-21-8-7-17(13-23(38)34(2)3)12-20(21)18-9-11-40-15-18/h4,7-9,11-12,15-16,19H,1,5-6,10,13-14H2,2-3H3,(H,32,39)(H2,29,30,31)/t19-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376916
PNG
(US10329300, Example 10 | US9920060, 10)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1F
Show InChI InChI=1S/C25H29FN8O3/c1-5-19(35)33-8-6-7-16(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-18-11-17(26)15(9-14(18)2)10-20(36)32(3)4/h5,9,11,13,16H,1,6-8,10,12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376926
PNG
(US10329300, Example 20 | US9920060, 20)
Show SMILES CN(C)C(=O)Cc1cc(Cl)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C24H26Cl2N8O3/c1-4-18(35)33-7-5-6-14(11-33)34-23-20(22(27)28-12-29-23)21(31-34)24(37)30-17-10-15(25)13(8-16(17)26)9-19(36)32(2)3/h4,8,10,12,14H,1,5-7,9,11H2,2-3H3,(H,30,37)(H2,27,28,29)/t14-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376943
PNG
(US10329300, Example 31 | US9920060, 31)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(F)c1
Show InChI InChI=1S/C23H25FN8O4/c1-4-17(33)31-9-5-6-13(11-31)32-21-18(20(25)26-12-27-21)19(29-32)22(34)28-16-8-7-14(10-15(16)24)36-23(35)30(2)3/h4,7-8,10,12-13H,1,5-6,9,11H2,2-3H3,(H,28,34)(H2,25,26,27)/t13-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376965
PNG
(US10329300, Example 53 | US9920060, 53)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c2OCOc12
Show InChI InChI=1S/C25H28N8O5/c1-4-17(34)32-9-5-6-15(11-32)33-24-19(23(26)27-12-28-24)20(30-33)25(36)29-16-8-7-14(10-18(35)31(2)3)21-22(16)38-13-37-21/h4,7-8,12,15H,1,5-6,9-11,13H2,2-3H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376955
PNG
(US10329300, Example 43 | US9920060, 43)
Show SMILES CN(C)C(=O)Oc1c(F)cc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1F
Show InChI InChI=1S/C23H24F2N8O4/c1-4-16(34)32-7-5-6-13(10-32)33-21-17(20(26)27-11-28-21)18(30-33)22(35)29-12-8-14(24)19(15(25)9-12)37-23(36)31(2)3/h4,8-9,11,13H,1,5-7,10H2,2-3H3,(H,29,35)(H2,26,27,28)/t13-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376990
PNG
(1-((3R,5S)-1-acryloyl-5-methylpyrrolidin-3-yl)-4-a...)
Show SMILES C[C@@H]1C[C@H](CN1C(=O)C=C)n1nc(C(=O)Nc2ccc(CC(=O)N(C)C)cc2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C24H27ClN8O3/c1-5-18(34)32-11-15(8-13(32)2)33-23-20(22(26)27-12-28-23)21(30-33)24(36)29-17-7-6-14(9-16(17)25)10-19(35)31(3)4/h5-7,9,12-13,15H,1,8,10-11H2,2-4H3,(H,29,36)(H2,26,27,28)/t13-,15-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376947
PNG
(US10329300, Example 35 | US9920060, 35)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(F)c1F
Show InChI InChI=1S/C23H24F2N8O4/c1-4-15(34)32-9-5-6-12(10-32)33-21-16(20(26)27-11-28-21)19(30-33)22(35)29-13-7-8-14(18(25)17(13)24)37-23(36)31(2)3/h4,7-8,11-12H,1,5-6,9-10H2,2-3H3,(H,29,35)(H2,26,27,28)/t12-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376987
PNG
(US10329300, Example 75 | US9920060, 75)
Show SMILES Cc1cc(NC(=O)N2CCCC2)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C26H31N9O3/c1-3-20(36)34-12-6-7-18(14-34)35-24-21(23(27)28-15-29-24)22(32-35)25(37)31-19-9-8-17(13-16(19)2)30-26(38)33-10-4-5-11-33/h3,8-9,13,15,18H,1,4-7,10-12,14H2,2H3,(H,30,38)(H,31,37)(H2,27,28,29)/t18-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376963
PNG
(US10329300, Example 51 | US9920060, 51)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(c1)-c1ccco1
Show InChI InChI=1S/C28H30N8O4/c1-4-22(37)35-11-5-7-18(15-35)36-27-24(26(29)30-16-31-27)25(33-36)28(39)32-20-10-9-17(14-23(38)34(2)3)13-19(20)21-8-6-12-40-21/h4,6,8-10,12-13,16,18H,1,5,7,11,14-15H2,2-3H3,(H,32,39)(H2,29,30,31)/t18-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376991
PNG
(US9920060, 79)
Show SMILES C[C@@H]1C[C@H](CN1C(=O)C=C)n1nc(C(=O)Nc2ccc(CC(=O)N(C)C)c(C)c2C)c2c(N)ncnc12
Show InChI InChI=1S/C26H32N8O3/c1-7-20(35)33-12-18(10-14(33)2)34-25-22(24(27)28-13-29-25)23(31-34)26(37)30-19-9-8-17(15(3)16(19)4)11-21(36)32(5)6/h7-9,13-14,18H,1,10-12H2,2-6H3,(H,30,37)(H2,27,28,29)/t14-,18-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376986
PNG
(US10329300, Example 74 | US9920060, 74)
Show SMILES CN(C)C(=O)Nc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C24H29N9O3/c1-5-18(34)32-10-6-7-16(12-32)33-22-19(21(25)26-13-27-22)20(30-33)23(35)29-17-9-8-15(11-14(17)2)28-24(36)31(3)4/h5,8-9,11,13,16H,1,6-7,10,12H2,2-4H3,(H,28,36)(H,29,35)(H2,25,26,27)/t16-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376953
PNG
(US10329300, Example 41 | US9920060, 41)
Show SMILES CN(C)C(=O)Cc1ccnc2c(NC(=O)c3nn([C@@H]4CCCN(C4)C(=O)C=C)c4ncnc(N)c34)cccc12
Show InChI InChI=1S/C27H29N9O3/c1-4-20(37)35-12-6-7-17(14-35)36-26-22(25(28)30-15-31-26)24(33-36)27(39)32-19-9-5-8-18-16(10-11-29-23(18)19)13-21(38)34(2)3/h4-5,8-11,15,17H,1,6-7,12-14H2,2-3H3,(H,32,39)(H2,28,30,31)/t17-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376954
PNG
(US10329300, Example 42 | US9920060, 42)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1F
Show InChI InChI=1S/C24H27FN8O3/c1-4-18(34)32-9-5-6-16(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(36)29-15-8-7-14(17(25)11-15)10-19(35)31(2)3/h4,7-8,11,13,16H,1,5-6,9-10,12H2,2-3H3,(H,29,36)(H2,26,27,28)/t16-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376978
PNG
((R,E)-4-(4-amino-1-(1-(4-dimethylamino)but-2-enoyl...)
Show SMILES CN(C)C\C=C\C(=O)N1CCN[C@@H](C1)n1nc(C(=O)Nc2ccc(CC(=O)N(C)C)c3ccccc23)c2c(N)ncnc12
Show InChI InChI=1S/C30H36N10O3/c1-37(2)14-7-10-24(41)39-15-13-32-23(17-39)40-29-26(28(31)33-18-34-29)27(36-40)30(43)35-22-12-11-19(16-25(42)38(3)4)20-8-5-6-9-21(20)22/h5-12,18,23,32H,13-17H2,1-4H3,(H,35,43)(H2,31,33,34)/b10-7+/t23-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376972
PNG
(US10329300, Example 60 | US9920060, 60)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C=C)c1
Show InChI InChI=1S/C25H28N8O3/c1-5-16-11-15(12-20(35)31(3)4)7-8-18(16)29-25(36)22-21-23(26)27-14-28-24(21)33(30-22)17-9-10-32(13-17)19(34)6-2/h5-8,11,14,17H,1-2,9-10,12-13H2,3-4H3,(H,29,36)(H2,26,27,28)/t17-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376977
PNG
(US10329300, Example 65 | US9920060, 65)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1F
Show InChI InChI=1S/C23H24ClFN8O3/c1-4-15(34)32-8-7-13(10-32)33-22-17(21(26)27-11-28-22)20(30-33)23(36)29-14-6-5-12(19(25)18(14)24)9-16(35)31(2)3/h4-6,11,13H,1,7-10H2,2-3H3,(H,29,36)(H2,26,27,28)/t13-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376961
PNG
(US10329300, Example 49 | US9920060, 49)
Show SMILES CCc1cc(CC(=O)N(C)C)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C26H32N8O3/c1-5-17-12-16(13-21(36)32(3)4)9-10-19(17)30-26(37)23-22-24(27)28-15-29-25(22)34(31-23)18-8-7-11-33(14-18)20(35)6-2/h6,9-10,12,15,18H,2,5,7-8,11,13-14H2,1,3-4H3,(H,30,37)(H2,27,28,29)/t18-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376929
PNG
(US10329300, Example 23 | US9920060, 23)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(c1)C#N
Show InChI InChI=1S/C25H27N9O3/c1-4-19(35)33-9-5-6-17(13-33)34-24-21(23(27)28-14-29-24)22(31-34)25(37)30-18-8-7-15(10-16(18)12-26)11-20(36)32(2)3/h4,7-8,10,14,17H,1,5-6,9,11,13H2,2-3H3,(H,30,37)(H2,27,28,29)/t17-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376931
PNG
(US10329300, Example 25 | US9920060, 25)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(F)c1
Show InChI InChI=1S/C24H27FN8O3/c1-4-18(34)32-9-5-6-15(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(36)29-17-8-7-14(10-16(17)25)11-19(35)31(2)3/h4,7-8,10,13,15H,1,5-6,9,11-12H2,2-3H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376968
PNG
(US10329300, Example 56 | US9920060, 56)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1F
Show InChI InChI=1S/C24H27FN8O3/c1-5-17(34)32-9-8-15(11-32)33-23-19(22(26)27-12-28-23)21(30-33)24(36)29-16-7-6-14(20(25)13(16)2)10-18(35)31(3)4/h5-7,12,15H,1,8-11H2,2-4H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376951
PNG
(US10329300, Example 39 | US9920060, 39)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C26H32N8O3/c1-6-20(35)33-9-7-8-18(13-33)34-25-22(24(27)28-14-29-25)23(31-34)26(37)30-19-11-15(2)17(10-16(19)3)12-21(36)32(4)5/h6,10-11,14,18H,1,7-9,12-13H2,2-5H3,(H,30,37)(H2,27,28,29)/t18-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376952
PNG
(US10329300, Example 40 | US9920060, 40)
Show SMILES COc1cc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc1CC(=O)N(C)C
Show InChI InChI=1S/C25H30N8O4/c1-5-19(34)32-10-6-7-17(13-32)33-24-21(23(26)27-14-28-24)22(30-33)25(36)29-16-9-8-15(18(12-16)37-4)11-20(35)31(2)3/h5,8-9,12,14,17H,1,6-7,10-11,13H2,2-4H3,(H,29,36)(H2,26,27,28)/t17-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376927
PNG
((R)-4-(1-(1-acryloylpiperidin-3-yl)-4-amino-1H-pyr...)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1
Show InChI InChI=1S/C23H26N8O4/c1-4-17(32)30-11-5-6-15(12-30)31-21-18(20(24)25-13-26-21)19(28-31)22(33)27-14-7-9-16(10-8-14)35-23(34)29(2)3/h4,7-10,13,15H,1,5-6,11-12H2,2-3H3,(H,27,33)(H2,24,25,26)/t15-/m1/s1
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n/an/a 26n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376957
PNG
(US10329300, Example 45 | US9920060, 45)
Show SMILES CN(C)C(=O)Oc1c(Cl)cc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C23H24Cl2N8O4/c1-4-16(34)32-7-5-6-13(10-32)33-21-17(20(26)27-11-28-21)18(30-33)22(35)29-12-8-14(24)19(15(25)9-12)37-23(36)31(2)3/h4,8-9,11,13H,1,5-7,10H2,2-3H3,(H,29,35)(H2,26,27,28)/t13-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376966
PNG
(US10329300, Example 54 | US9920060, 54)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1
Show InChI InChI=1S/C23H25ClN8O3/c1-4-17(33)31-8-7-14(11-31)32-22-19(21(25)26-12-27-22)20(29-32)23(35)28-16-6-5-13(9-15(16)24)10-18(34)30(2)3/h4-6,9,12,14H,1,7-8,10-11H2,2-3H3,(H,28,35)(H2,25,26,27)/t14-/m1/s1
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n/an/a 31n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376969
PNG
(US10329300, Example 57 | US9920060, 57)
Show SMILES COc1c(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc(CC(=O)N(C)C)c1F
Show InChI InChI=1S/C24H27FN8O4/c1-5-16(34)32-9-8-14(11-32)33-23-18(22(26)27-12-28-23)20(30-33)24(36)29-15-7-6-13(10-17(35)31(2)3)19(25)21(15)37-4/h5-7,12,14H,1,8-11H2,2-4H3,(H,29,36)(H2,26,27,28)/t14-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376975
PNG
(US10329300, Example 63 | US9920060, 63)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C23H26N8O4/c1-5-17(32)30-9-8-14(11-30)31-21-18(20(24)25-12-26-21)19(28-31)22(33)27-16-7-6-15(10-13(16)2)35-23(34)29(3)4/h5-7,10,12,14H,1,8-9,11H2,2-4H3,(H,27,33)(H2,24,25,26)/t14-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376930
PNG
(US10329300, Example 24 | US9920060, 24)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C#N
Show InChI InChI=1S/C26H29N9O3/c1-5-20(36)34-8-6-7-18(13-34)35-25-22(24(28)29-14-30-25)23(32-35)26(38)31-19-10-17(12-27)16(9-15(19)2)11-21(37)33(3)4/h5,9-10,14,18H,1,6-8,11,13H2,2-4H3,(H,31,38)(H2,28,29,30)/t18-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376958
PNG
(US10329300, Example 46 | US9920060, 46)
Show SMILES CN(C)C(=O)Oc1c(C)cc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C25H30N8O4/c1-6-18(34)32-9-7-8-17(12-32)33-23-19(22(26)27-13-28-23)20(30-33)24(35)29-16-10-14(2)21(15(3)11-16)37-25(36)31(4)5/h6,10-11,13,17H,1,7-9,12H2,2-5H3,(H,29,35)(H2,26,27,28)/t17-/m1/s1
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n/an/a 44n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376971
PNG
(US10329300, Example 59 | US9920060, 59)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C
Show InChI InChI=1S/C25H30N8O3/c1-6-19(34)32-10-9-17(12-32)33-24-21(23(26)27-13-28-24)22(30-33)25(36)29-18-8-7-16(14(2)15(18)3)11-20(35)31(4)5/h6-8,13,17H,1,9-12H2,2-5H3,(H,29,36)(H2,26,27,28)/t17-/m1/s1
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n/an/a 45n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376934
PNG
(US10329300, Example 28 | US9920060, 28)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1
Show InChI InChI=1S/C24H28N8O3/c1-4-18(33)31-11-5-6-17(13-31)32-23-20(22(25)26-14-27-23)21(29-32)24(35)28-16-9-7-15(8-10-16)12-19(34)30(2)3/h4,7-10,14,17H,1,5-6,11-13H2,2-3H3,(H,28,35)(H2,25,26,27)/t17-/m1/s1
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n/an/a 46n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376956
PNG
(US10329300, Example 44 | US9920060, 44)
Show SMILES CN(C)C(=O)Oc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C25H30N8O4/c1-6-18(34)32-9-7-8-16(12-32)33-23-19(22(26)27-13-28-23)21(30-33)24(35)29-20-14(2)10-17(11-15(20)3)37-25(36)31(4)5/h6,10-11,13,16H,1,7-9,12H2,2-5H3,(H,29,35)(H2,26,27,28)/t16-/m1/s1
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n/an/a 46n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376928
PNG
(US10329300, Example 22 | US9920060, 22)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(c1)C1CC1
Show InChI InChI=1S/C27H32N8O3/c1-4-21(36)34-11-5-6-18(14-34)35-26-23(25(28)29-15-30-26)24(32-35)27(38)31-20-10-7-16(13-22(37)33(2)3)12-19(20)17-8-9-17/h4,7,10,12,15,17-18H,1,5-6,8-9,11,13-14H2,2-3H3,(H,31,38)(H2,28,29,30)/t18-/m1/s1
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n/an/a 48n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376976
PNG
(US10329300, Example 64 | US9920060, 64)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C
Show InChI InChI=1S/C24H28N8O4/c1-6-18(33)31-10-9-15(11-31)32-22-19(21(25)26-12-27-22)20(29-32)23(34)28-16-7-8-17(14(3)13(16)2)36-24(35)30(4)5/h6-8,12,15H,1,9-11H2,2-5H3,(H,28,34)(H2,25,26,27)/t15-/m1/s1
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n/an/a 49n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376967
PNG
(US10329300, Example 55 | US9920060, 55)
Show SMILES COc1c(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc(CC(=O)N(C)C)c1Cl
Show InChI InChI=1S/C24H27ClN8O4/c1-5-16(34)32-9-8-14(11-32)33-23-18(22(26)27-12-28-23)20(30-33)24(36)29-15-7-6-13(10-17(35)31(2)3)19(25)21(15)37-4/h5-7,12,14H,1,8-11H2,2-4H3,(H,29,36)(H2,26,27,28)/t14-/m1/s1
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n/an/a 49n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376959
PNG
(US10329300, Example 47 | US9920060, 47)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(c1)N(C)C
Show InChI InChI=1S/C26H33N9O3/c1-6-20(36)34-11-7-8-17(14-34)35-25-22(24(27)28-15-29-25)23(31-35)26(38)30-18-10-9-16(12-19(18)32(2)3)13-21(37)33(4)5/h6,9-10,12,15,17H,1,7-8,11,13-14H2,2-5H3,(H,30,38)(H2,27,28,29)/t17-/m1/s1
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n/an/a 52n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376973
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-4-amino-N-(4-(2-...)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ccccc12
Show InChI InChI=1S/C27H28N8O3/c1-4-21(36)34-12-11-17(14-34)35-26-23(25(28)29-15-30-26)24(32-35)27(38)31-20-10-9-16(13-22(37)33(2)3)18-7-5-6-8-19(18)20/h4-10,15,17H,1,11-14H2,2-3H3,(H,31,38)(H2,28,29,30)/t17-/m1/s1
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n/an/a 59n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM130909
PNG
(US8822500, Stauro- sporine | US9920060, Staurospor...)
Show SMILES CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1S/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)
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US Patent
n/an/a 63n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376979
PNG
(US10329300, Example 67 | US9920060, 67)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C24H27ClN8O3/c1-5-18(34)32-7-6-15(11-32)33-23-20(22(26)27-12-28-23)21(30-33)24(36)29-17-10-16(25)14(8-13(17)2)9-19(35)31(3)4/h5,8,10,12,15H,1,6-7,9,11H2,2-4H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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n/an/a 72n/an/an/an/an/an/a



Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376985
PNG
(US10329300, Example 73 | US9920060, 73)
Show SMILES Cc1cc(CC(=O)N2CC(O)C2)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C26H30N8O4/c1-3-20(36)32-8-4-5-17(11-32)34-25-22(24(27)28-14-29-25)23(31-34)26(38)30-19-7-6-16(9-15(19)2)10-21(37)33-12-18(35)13-33/h3,6-7,9,14,17-18,35H,1,4-5,8,10-13H2,2H3,(H,30,38)(H2,27,28,29)/t17-/m1/s1
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Taiho Pharmaceutical Co., Ltd

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)


BindingDB Entry DOI: 10.7270/Q2BR8VHD
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%