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Patent code US9920060

Compile Data Set for Download or QSAR
Found 80 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376962
PNG
(US9920060, 50)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1F
Show InChI InChI=1S/C24H26ClFN8O3/c1-4-16(35)33-9-5-6-14(11-33)34-23-18(22(27)28-12-29-23)21(31-34)24(37)30-15-8-7-13(20(26)19(15)25)10-17(36)32(2)3/h4,7-8,12,14H,1,5-6,9-11H2,2-3H3,(H,30,37)(H2,27,28,29)/t14-/m1/s1
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n/an/a 2.90n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376933
PNG
(US9920060, 27)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1
Show InChI InChI=1S/C23H25ClN8O4/c1-4-17(33)31-9-5-6-13(11-31)32-21-18(20(25)26-12-27-21)19(29-32)22(34)28-16-8-7-14(10-15(16)24)36-23(35)30(2)3/h4,7-8,10,12-13H,1,5-6,9,11H2,2-3H3,(H,28,34)(H2,25,26,27)/t13-/m1/s1
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n/an/a 3.90n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376912
PNG
(US9920060, 6)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1
Show InChI InChI=1S/C24H27ClN8O3/c1-4-18(34)32-9-5-6-15(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(36)29-17-8-7-14(10-16(17)25)11-19(35)31(2)3/h4,7-8,10,13,15H,1,5-6,9,11-12H2,2-3H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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n/an/a 4n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376924
PNG
(US9920060, 18)
Show SMILES CN(C)C(=O)Cc1cc(Cl)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1F
Show InChI InChI=1S/C24H26ClFN8O3/c1-4-18(35)33-7-5-6-14(11-33)34-23-20(22(27)28-12-29-23)21(31-34)24(37)30-17-10-16(26)13(8-15(17)25)9-19(36)32(2)3/h4,8,10,12,14H,1,5-7,9,11H2,2-3H3,(H,30,37)(H2,27,28,29)/t14-/m1/s1
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n/an/a 4.40n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376920
PNG
(US9920060, 14)
Show SMILES COc1c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc(CC(=O)N(C)C)c1F
Show InChI InChI=1S/C25H29FN8O4/c1-5-17(35)33-10-6-7-15(12-33)34-24-19(23(27)28-13-29-24)21(31-34)25(37)30-16-9-8-14(11-18(36)32(2)3)20(26)22(16)38-4/h5,8-9,13,15H,1,6-7,10-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t15-/m1/s1
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n/an/a 4.60n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376988
PNG
(US9920060, 76)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CC(F)CN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1
Show InChI InChI=1S/C24H26ClFN8O3/c1-4-18(35)33-10-14(26)9-15(11-33)34-23-20(22(27)28-12-29-23)21(31-34)24(37)30-17-6-5-13(7-16(17)25)8-19(36)32(2)3/h4-7,12,14-15H,1,8-11H2,2-3H3,(H,30,37)(H2,27,28,29)/t14?,15-/m1/s1
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n/an/a 5n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376948
PNG
(US9920060, 36)
Show SMILES COc1cc(OC(=O)N(C)C)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C24H28N8O5/c1-5-18(33)31-10-6-7-14(12-31)32-22-19(21(25)26-13-27-22)20(29-32)23(34)28-16-9-8-15(11-17(16)36-4)37-24(35)30(2)3/h5,8-9,11,13-14H,1,6-7,10,12H2,2-4H3,(H,28,34)(H2,25,26,27)/t14-/m1/s1
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n/an/a 5.40n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376923
PNG
(US9920060, 17)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Br)c1
Show InChI InChI=1S/C24H27BrN8O3/c1-4-18(34)32-9-5-6-15(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(36)29-17-8-7-14(10-16(17)25)11-19(35)31(2)3/h4,7-8,10,13,15H,1,5-6,9,11-12H2,2-3H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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n/an/a 5.90n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376945
PNG
((R)-4-(1-(1-acryloylpiperidin-3-yl)-4-amino-1H-pyr...)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ccccc12
Show InChI InChI=1S/C27H28N8O4/c1-4-21(36)34-13-7-8-16(14-34)35-25-22(24(28)29-15-30-25)23(32-35)26(37)31-19-11-12-20(39-27(38)33(2)3)18-10-6-5-9-17(18)19/h4-6,9-12,15-16H,1,7-8,13-14H2,2-3H3,(H,31,37)(H2,28,29,30)/t16-/m1/s1
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n/an/a 6n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376941
PNG
(US9920060, 29)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C23H25ClN8O4/c1-4-17(33)31-9-5-6-14(11-31)32-21-18(20(25)26-12-27-21)19(29-32)22(34)28-13-7-8-16(15(24)10-13)36-23(35)30(2)3/h4,7-8,10,12,14H,1,5-6,9,11H2,2-3H3,(H,28,34)(H2,25,26,27)/t14-/m1/s1
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n/an/a 6.5n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376932
PNG
(US9920060, 26)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C24H28N8O4/c1-5-18(33)31-10-6-7-15(12-31)32-22-19(21(25)26-13-27-22)20(29-32)23(34)28-17-9-8-16(11-14(17)2)36-24(35)30(3)4/h5,8-9,11,13,15H,1,6-7,10,12H2,2-4H3,(H,28,34)(H2,25,26,27)/t15-/m1/s1
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n/an/a 7n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376913
PNG
(US9920060, 7)
Show SMILES COc1cc(CC(=O)N(C)C)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C25H30N8O4/c1-5-19(34)32-10-6-7-16(13-32)33-24-21(23(26)27-14-28-24)22(30-33)25(36)29-17-9-8-15(11-18(17)37-4)12-20(35)31(2)3/h5,8-9,11,14,16H,1,6-7,10,12-13H2,2-4H3,(H,29,36)(H2,26,27,28)/t16-/m1/s1
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n/an/a 7.10n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376909
PNG
(US9920060, 3)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1C
Show InChI InChI=1S/C25H29ClN8O3/c1-5-18(35)33-10-6-7-16(12-33)34-24-20(23(27)28-13-29-24)22(31-34)25(37)30-17-9-8-15(14(2)21(17)26)11-19(36)32(3)4/h5,8-9,13,16H,1,6-7,10-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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n/an/a 7.10n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376917
PNG
(US9920060, 11)
Show SMILES COc1c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc(CC(=O)N(C)C)c1Cl
Show InChI InChI=1S/C25H29ClN8O4/c1-5-17(35)33-10-6-7-15(12-33)34-24-19(23(27)28-13-29-24)21(31-34)25(37)30-16-9-8-14(11-18(36)32(2)3)20(26)22(16)38-4/h5,8-9,13,15H,1,6-7,10-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t15-/m1/s1
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n/an/a 7.5n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376918
PNG
(US9920060, 12)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1F
Show InChI InChI=1S/C25H29FN8O3/c1-5-18(35)33-10-6-7-16(12-33)34-24-20(23(27)28-13-29-24)22(31-34)25(37)30-17-9-8-15(21(26)14(17)2)11-19(36)32(3)4/h5,8-9,13,16H,1,6-7,10-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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n/an/a 7.5n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376980
PNG
((R)-4-(1-(1-acryloylpyrimidin-3-yl)-4-amino-1H-pyr...)
Show SMILES CN(C(=O)Oc1ccc(NC(=O)c2nn(N3CN(CC=C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1)c1ccccc1
Show InChI InChI=1S/C28H27N9O4/c1-4-22(38)35-13-8-14-36(17-35)37-26-23(25(29)30-16-31-26)24(33-37)27(39)32-21-12-11-20(15-18(21)2)41-28(40)34(3)19-9-6-5-7-10-19/h4-12,14-16H,1,13,17H2,2-3H3,(H,32,39)(H2,29,30,31)
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n/an/a 7.70n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376908
PNG
(US9920060, 2)
Show SMILES CN(C)C(=O)Cc1cc(Cl)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C25H29ClN8O3/c1-5-19(35)33-8-6-7-16(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-18-9-14(2)15(10-17(18)26)11-20(36)32(3)4/h5,9-10,13,16H,1,6-8,11-12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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n/an/a 8.30n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376960
PNG
(US9920060, 48)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C=C)c1
Show InChI InChI=1S/C26H30N8O3/c1-5-17-12-16(13-21(36)32(3)4)9-10-19(17)30-26(37)23-22-24(27)28-15-29-25(22)34(31-23)18-8-7-11-33(14-18)20(35)6-2/h5-6,9-10,12,15,18H,1-2,7-8,11,13-14H2,3-4H3,(H,30,37)(H2,27,28,29)/t18-/m1/s1
PDB
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n/an/a 8.5n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376921
PNG
(US9920060, 15)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(OC(F)F)c1
Show InChI InChI=1S/C25H28F2N8O4/c1-4-18(36)34-9-5-6-15(12-34)35-23-20(22(28)29-13-30-23)21(32-35)24(38)31-16-8-7-14(11-19(37)33(2)3)10-17(16)39-25(26)27/h4,7-8,10,13,15,25H,1,5-6,9,11-12H2,2-3H3,(H,31,38)(H2,28,29,30)/t15-/m1/s1
PDB
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n/an/a 8.60n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376942
PNG
(US9920060, 30)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C24H28N8O4/c1-5-18(33)31-10-6-7-16(12-31)32-22-19(21(25)26-13-27-22)20(29-32)23(34)28-15-8-9-17(14(2)11-15)36-24(35)30(3)4/h5,8-9,11,13,16H,1,6-7,10,12H2,2-4H3,(H,28,34)(H2,25,26,27)/t16-/m1/s1
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n/an/a 8.70n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376981
PNG
(US9920060, 69)
Show SMILES Cc1cc(OC(=O)N2CCCC2)ccc1NC(=O)c1nn(N2CC=CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C25H27N9O4/c1-3-19(35)32-11-6-12-33(15-32)34-23-20(22(26)27-14-28-23)21(30-34)24(36)29-18-8-7-17(13-16(18)2)38-25(37)31-9-4-5-10-31/h3,6-8,11,13-14H,1,4-5,9-10,12,15H2,2H3,(H,29,36)(H2,26,27,28)
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n/an/a 9.20n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376914
PNG
(US9920060, 8)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C24H27ClN8O3/c1-4-18(34)32-9-5-6-16(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(36)29-15-8-7-14(17(25)11-15)10-19(35)31(2)3/h4,7-8,11,13,16H,1,5-6,9-10,12H2,2-3H3,(H,29,36)(H2,26,27,28)/t16-/m1/s1
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n/an/a 9.20n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376944
PNG
(US9920060, 32)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C
Show InChI InChI=1S/C25H30N8O4/c1-6-19(34)32-11-7-8-16(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(35)29-17-9-10-18(15(3)14(17)2)37-25(36)31(4)5/h6,9-10,13,16H,1,7-8,11-12H2,2-5H3,(H,29,35)(H2,26,27,28)/t16-/m1/s1
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n/an/a 9.30n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376982
PNG
(US9920060, 70)
Show SMILES Cc1cc(OC(=O)N2CCCCC2)ccc1NC(=O)c1nn(N2CC=CN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C26H29N9O4/c1-3-20(36)33-12-7-13-34(16-33)35-24-21(23(27)28-15-29-24)22(31-35)25(37)30-19-9-8-18(14-17(19)2)39-26(38)32-10-5-4-6-11-32/h3,7-9,12,14-15H,1,4-6,10-11,13,16H2,2H3,(H,30,37)(H2,27,28,29)
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n/an/a 10n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376922
PNG
(US9920060, 16)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(OCF)c1
Show InChI InChI=1S/C25H29FN8O4/c1-4-19(35)33-9-5-6-16(12-33)34-24-21(23(27)28-14-29-24)22(31-34)25(37)30-17-8-7-15(10-18(17)38-13-26)11-20(36)32(2)3/h4,7-8,10,14,16H,1,5-6,9,11-13H2,2-3H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376950
PNG
(US9920060, 38)
Show SMILES CN(C)C(=O)Oc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C25H30N8O4/c1-6-19(34)32-9-7-8-16(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(35)29-17-10-15(3)18(11-14(17)2)37-25(36)31(4)5/h6,10-11,13,16H,1,7-9,12H2,2-5H3,(H,29,35)(H2,26,27,28)/t16-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376915
PNG
(US9920060, 9)
Show SMILES COc1cc(CC(=O)N(C)C)c(Cl)cc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C25H29ClN8O4/c1-5-19(35)33-8-6-7-15(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-17-11-16(26)14(9-18(17)38-4)10-20(36)32(2)3/h5,9,11,13,15H,1,6-8,10,12H2,2-4H3,(H,30,37)(H2,27,28,29)/t15-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376907
PNG
(US9920060, 1)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Br
Show InChI InChI=1S/C25H29BrN8O3/c1-5-19(35)33-8-6-7-16(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-18-11-17(26)15(9-14(18)2)10-20(36)32(3)4/h5,9,11,13,16H,1,6-8,10,12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376925
PNG
(US9920060, 19)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C25H29ClN8O3/c1-5-19(35)33-8-6-7-16(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-18-11-17(26)15(9-14(18)2)10-20(36)32(3)4/h5,9,11,13,16H,1,6-8,10,12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376970
PNG
((R)-4-(1-(1-acryloylpyrrolidin-3-yl)-4-amino-1H-py...)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ccccc12
Show InChI InChI=1S/C26H26N8O4/c1-4-20(35)33-12-11-15(13-33)34-24-21(23(27)28-14-29-24)22(31-34)25(36)30-18-9-10-19(38-26(37)32(2)3)17-8-6-5-7-16(17)18/h4-10,14-15H,1,11-13H2,2-3H3,(H,30,36)(H2,27,28,29)/t15-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376983
PNG
(US9920060, 71)
Show SMILES Cc1cc(CC(=O)N2CCCC2)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C27H32N8O3/c1-3-21(36)34-12-6-7-19(15-34)35-26-23(25(28)29-16-30-26)24(32-35)27(38)31-20-9-8-18(13-17(20)2)14-22(37)33-10-4-5-11-33/h3,8-9,13,16,19H,1,4-7,10-12,14-15H2,2H3,(H,31,38)(H2,28,29,30)/t19-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376911
PNG
(US9920060, 5)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ccccc12
Show InChI InChI=1S/C28H30N8O3/c1-4-22(37)35-13-7-8-18(15-35)36-27-24(26(29)30-16-31-27)25(33-36)28(39)32-21-12-11-17(14-23(38)34(2)3)19-9-5-6-10-20(19)21/h4-6,9-12,16,18H,1,7-8,13-15H2,2-3H3,(H,32,39)(H2,29,30,31)/t18-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376946
PNG
(US9920060, 34)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1F
Show InChI InChI=1S/C23H25FN8O4/c1-4-17(33)31-9-5-6-14(11-31)32-21-18(20(25)26-12-27-21)19(29-32)22(34)28-13-7-8-16(15(24)10-13)36-23(35)30(2)3/h4,7-8,10,12,14H,1,5-6,9,11H2,2-3H3,(H,28,34)(H2,25,26,27)/t14-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376949
PNG
(US9920060, 37)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ncccc12
Show InChI InChI=1S/C26H27N9O4/c1-4-19(36)34-12-6-7-15(13-34)35-24-20(23(27)29-14-30-24)22(32-35)25(37)31-17-9-10-18(39-26(38)33(2)3)16-8-5-11-28-21(16)17/h4-5,8-11,14-15H,1,6-7,12-13H2,2-3H3,(H,31,37)(H2,27,29,30)/t15-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376984
PNG
(US9920060, 72)
Show SMILES CN[C@@H](C(=O)OC)c1ccc(NC(=O)c2nn(C3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C25H30N8O4/c1-5-18(34)32-10-6-7-16(12-32)33-23-19(22(26)28-13-29-23)21(31-33)24(35)30-17-9-8-15(11-14(17)2)20(27-3)25(36)37-4/h5,8-9,11,13,16,20,27H,1,6-7,10,12H2,2-4H3,(H,30,35)(H2,26,28,29)/t16?,20-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376910
PNG
(US9920060, 4)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C25H30N8O3/c1-5-19(34)32-10-6-7-17(13-32)33-24-21(23(26)27-14-28-24)22(30-33)25(36)29-18-9-8-16(11-15(18)2)12-20(35)31(3)4/h5,8-9,11,14,17H,1,6-7,10,12-13H2,2-4H3,(H,29,36)(H2,26,27,28)/t17-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376919
PNG
(US9920060, 13)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C
Show InChI InChI=1S/C26H32N8O3/c1-6-20(35)33-11-7-8-18(13-33)34-25-22(24(27)28-14-29-25)23(31-34)26(37)30-19-10-9-17(15(2)16(19)3)12-21(36)32(4)5/h6,9-10,14,18H,1,7-8,11-13H2,2-5H3,(H,30,37)(H2,27,28,29)/t18-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376973
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-4-amino-N-(4-(2-...)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ccccc12
Show InChI InChI=1S/C27H28N8O3/c1-4-21(36)34-12-11-17(14-34)35-26-23(25(28)29-15-30-26)24(32-35)27(38)31-20-10-9-16(13-22(37)33(2)3)18-7-5-6-8-19(18)20/h4-10,15,17H,1,11-14H2,2-3H3,(H,31,38)(H2,28,29,30)/t17-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376989
PNG
(US9920060, 77)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CC(F)CN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C
Show InChI InChI=1S/C26H31FN8O3/c1-6-20(36)34-11-17(27)10-18(12-34)35-25-22(24(28)29-13-30-25)23(32-35)26(38)31-19-8-7-16(14(2)15(19)3)9-21(37)33(4)5/h6-8,13,17-18H,1,9-12H2,2-5H3,(H,31,38)(H2,28,29,30)/t17?,18-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376964
PNG
(US9920060, 52)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(c1)-c1ccoc1
Show InChI InChI=1S/C28H30N8O4/c1-4-22(37)35-10-5-6-19(14-35)36-27-24(26(29)30-16-31-27)25(33-36)28(39)32-21-8-7-17(13-23(38)34(2)3)12-20(21)18-9-11-40-15-18/h4,7-9,11-12,15-16,19H,1,5-6,10,13-14H2,2-3H3,(H,32,39)(H2,29,30,31)/t19-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376916
PNG
(US9920060, 10)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1F
Show InChI InChI=1S/C25H29FN8O3/c1-5-19(35)33-8-6-7-16(12-33)34-24-21(23(27)28-13-29-24)22(31-34)25(37)30-18-11-17(26)15(9-14(18)2)10-20(36)32(3)4/h5,9,11,13,16H,1,6-8,10,12H2,2-4H3,(H,30,37)(H2,27,28,29)/t16-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376926
PNG
(US9920060, 20)
Show SMILES CN(C)C(=O)Cc1cc(Cl)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C24H26Cl2N8O3/c1-4-18(35)33-7-5-6-14(11-33)34-23-20(22(27)28-12-29-23)21(31-34)24(37)30-17-10-15(25)13(8-16(17)26)9-19(36)32(2)3/h4,8,10,12,14H,1,5-7,9,11H2,2-3H3,(H,30,37)(H2,27,28,29)/t14-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376943
PNG
(US9920060, 31)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(F)c1
Show InChI InChI=1S/C23H25FN8O4/c1-4-17(33)31-9-5-6-13(11-31)32-21-18(20(25)26-12-27-21)19(29-32)22(34)28-16-8-7-14(10-15(16)24)36-23(35)30(2)3/h4,7-8,10,12-13H,1,5-6,9,11H2,2-3H3,(H,28,34)(H2,25,26,27)/t13-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376965
PNG
(US9920060, 53)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c2OCOc12
Show InChI InChI=1S/C25H28N8O5/c1-4-17(34)32-9-5-6-15(11-32)33-24-19(23(26)27-12-28-24)20(30-33)25(36)29-16-8-7-14(10-18(35)31(2)3)21-22(16)38-13-37-21/h4,7-8,12,15H,1,5-6,9-11,13H2,2-3H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376955
PNG
(US9920060, 43)
Show SMILES CN(C)C(=O)Oc1c(F)cc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1F
Show InChI InChI=1S/C23H24F2N8O4/c1-4-16(34)32-7-5-6-13(10-32)33-21-17(20(26)27-11-28-21)18(30-33)22(35)29-12-8-14(24)19(15(25)9-12)37-23(36)31(2)3/h4,8-9,11,13H,1,5-7,10H2,2-3H3,(H,29,35)(H2,26,27,28)/t13-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376990
PNG
(1-((3R,5S)-1-acryloyl-5-methylpyrrolidin-3-yl)-4-a...)
Show SMILES C[C@@H]1C[C@H](CN1C(=O)C=C)n1nc(C(=O)Nc2ccc(CC(=O)N(C)C)cc2Cl)c2c(N)ncnc12
Show InChI InChI=1S/C24H27ClN8O3/c1-5-18(34)32-11-15(8-13(32)2)33-23-20(22(26)27-12-28-23)21(30-33)24(36)29-17-7-6-14(9-16(17)25)10-19(35)31(3)4/h5-7,9,12-13,15H,1,8,10-11H2,2-4H3,(H,29,36)(H2,26,27,28)/t13-,15-/m1/s1
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n/an/a 14n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376947
PNG
(US9920060, 35)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(F)c1F
Show InChI InChI=1S/C23H24F2N8O4/c1-4-15(34)32-9-5-6-12(10-32)33-21-16(20(26)27-11-28-21)19(30-33)22(35)29-13-7-8-14(18(25)17(13)24)37-23(36)31(2)3/h4,7-8,11-12H,1,5-6,9-10H2,2-3H3,(H,29,35)(H2,26,27,28)/t12-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376987
PNG
(US9920060, 75)
Show SMILES Cc1cc(NC(=O)N2CCCC2)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C26H31N9O3/c1-3-20(36)34-12-6-7-18(14-34)35-24-21(23(27)28-15-29-24)22(32-35)25(37)31-19-9-8-17(13-16(19)2)30-26(38)33-10-4-5-11-33/h3,8-9,13,15,18H,1,4-7,10-12,14H2,2H3,(H,30,38)(H,31,37)(H2,27,28,29)/t18-/m1/s1
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n/an/a 16n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376963
PNG
(US9920060, 51)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(c1)-c1ccco1
Show InChI InChI=1S/C28H30N8O4/c1-4-22(37)35-11-5-7-18(15-35)36-27-24(26(29)30-16-31-27)25(33-36)28(39)32-20-10-9-17(14-23(38)34(2)3)13-19(20)21-8-6-12-40-21/h4,6,8-10,12-13,16,18H,1,5,7,11,14-15H2,2-3H3,(H,32,39)(H2,29,30,31)/t18-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376991
PNG
(US9920060, 79)
Show SMILES C[C@@H]1C[C@H](CN1C(=O)C=C)n1nc(C(=O)Nc2ccc(CC(=O)N(C)C)c(C)c2C)c2c(N)ncnc12
Show InChI InChI=1S/C26H32N8O3/c1-7-20(35)33-12-18(10-14(33)2)34-25-22(24(27)28-13-29-25)23(31-34)26(37)30-19-9-8-17(15(3)16(19)4)11-21(36)32(5)6/h7-9,13-14,18H,1,10-12H2,2-6H3,(H,30,37)(H2,27,28,29)/t14-,18-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376986
PNG
(US9920060, 74)
Show SMILES CN(C)C(=O)Nc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C24H29N9O3/c1-5-18(34)32-10-6-7-16(12-32)33-22-19(21(25)26-13-27-22)20(30-33)23(35)29-17-9-8-15(11-14(17)2)28-24(36)31(3)4/h5,8-9,11,13,16H,1,6-7,10,12H2,2-4H3,(H,28,36)(H,29,35)(H2,25,26,27)/t16-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376953
PNG
(US9920060, 41)
Show SMILES CN(C)C(=O)Cc1ccnc2c(NC(=O)c3nn([C@@H]4CCCN(C4)C(=O)C=C)c4ncnc(N)c34)cccc12
Show InChI InChI=1S/C27H29N9O3/c1-4-20(37)35-12-6-7-17(14-35)36-26-22(25(28)30-15-31-26)24(33-36)27(39)32-19-9-5-8-18-16(10-11-29-23(18)19)13-21(38)34(2)3/h4-5,8-11,15,17H,1,6-7,12-14H2,2-3H3,(H,32,39)(H2,28,30,31)/t17-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376954
PNG
(US9920060, 42)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1F
Show InChI InChI=1S/C24H27FN8O3/c1-4-18(34)32-9-5-6-16(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(36)29-15-8-7-14(17(25)11-15)10-19(35)31(2)3/h4,7-8,11,13,16H,1,5-6,9-10,12H2,2-3H3,(H,29,36)(H2,26,27,28)/t16-/m1/s1
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n/an/a 18n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376978
PNG
((R,E)-4-(4-amino-1-(1-(4-dimethylamino)but-2-enoyl...)
Show SMILES CN(C)C\C=C\C(=O)N1CCN[C@@H](C1)n1nc(C(=O)Nc2ccc(CC(=O)N(C)C)c3ccccc23)c2c(N)ncnc12
Show InChI InChI=1S/C30H36N10O3/c1-37(2)14-7-10-24(41)39-15-13-32-23(17-39)40-29-26(28(31)33-18-34-29)27(36-40)30(43)35-22-12-11-19(16-25(42)38(3)4)20-8-5-6-9-21(20)22/h5-12,18,23,32H,13-17H2,1-4H3,(H,35,43)(H2,31,33,34)/b10-7+/t23-/m1/s1
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n/an/a 19n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376972
PNG
(US9920060, 60)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C=C)c1
Show InChI InChI=1S/C25H28N8O3/c1-5-16-11-15(12-20(35)31(3)4)7-8-18(16)29-25(36)22-21-23(26)27-14-28-24(21)33(30-22)17-9-10-32(13-17)19(34)6-2/h5-8,11,14,17H,1-2,9-10,12-13H2,3-4H3,(H,29,36)(H2,26,27,28)/t17-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376977
PNG
(US9920060, 65)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1F
Show InChI InChI=1S/C23H24ClFN8O3/c1-4-15(34)32-8-7-13(10-32)33-22-17(21(26)27-11-28-22)20(30-33)23(36)29-14-6-5-12(19(25)18(14)24)9-16(35)31(2)3/h4-6,11,13H,1,7-10H2,2-3H3,(H,29,36)(H2,26,27,28)/t13-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376961
PNG
(US9920060, 49)
Show SMILES CCc1cc(CC(=O)N(C)C)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C26H32N8O3/c1-5-17-12-16(13-21(36)32(3)4)9-10-19(17)30-26(37)23-22-24(27)28-15-29-25(22)34(31-23)18-8-7-11-33(14-18)20(35)6-2/h6,9-10,12,15,18H,2,5,7-8,11,13-14H2,1,3-4H3,(H,30,37)(H2,27,28,29)/t18-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376929
PNG
(US9920060, 23)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(c1)C#N
Show InChI InChI=1S/C25H27N9O3/c1-4-19(35)33-9-5-6-17(13-33)34-24-21(23(27)28-14-29-24)22(31-34)25(37)30-18-8-7-15(10-16(18)12-26)11-20(36)32(2)3/h4,7-8,10,14,17H,1,5-6,9,11,13H2,2-3H3,(H,30,37)(H2,27,28,29)/t17-/m1/s1
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n/an/a 20n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376931
PNG
(US9920060, 25)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(F)c1
Show InChI InChI=1S/C24H27FN8O3/c1-4-18(34)32-9-5-6-15(12-32)33-23-20(22(26)27-13-28-23)21(30-33)24(36)29-17-8-7-14(10-16(17)25)11-19(35)31(2)3/h4,7-8,10,13,15H,1,5-6,9,11-12H2,2-3H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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n/an/a 21n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376968
PNG
(US9920060, 56)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1F
Show InChI InChI=1S/C24H27FN8O3/c1-5-17(34)32-9-8-15(11-32)33-23-19(22(26)27-12-28-23)21(30-33)24(36)29-16-7-6-14(20(25)13(16)2)10-18(35)31(3)4/h5-7,12,15H,1,8-11H2,2-4H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376951
PNG
(US9920060, 39)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C26H32N8O3/c1-6-20(35)33-9-7-8-18(13-33)34-25-22(24(27)28-14-29-25)23(31-34)26(37)30-19-11-15(2)17(10-16(19)3)12-21(36)32(4)5/h6,10-11,14,18H,1,7-9,12-13H2,2-5H3,(H,30,37)(H2,27,28,29)/t18-/m1/s1
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n/an/a 22n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376952
PNG
(US9920060, 40)
Show SMILES COc1cc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc1CC(=O)N(C)C
Show InChI InChI=1S/C25H30N8O4/c1-5-19(34)32-10-6-7-17(13-32)33-24-21(23(26)27-14-28-24)22(30-33)25(36)29-16-9-8-15(18(12-16)37-4)11-20(35)31(2)3/h5,8-9,12,14,17H,1,6-7,10-11,13H2,2-4H3,(H,29,36)(H2,26,27,28)/t17-/m1/s1
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n/an/a 23n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376927
PNG
((R)-4-(1-(1-acryloylpiperidin-3-yl)-4-amino-1H-pyr...)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1
Show InChI InChI=1S/C23H26N8O4/c1-4-17(32)30-11-5-6-15(12-30)31-21-18(20(24)25-13-26-21)19(28-31)22(33)27-14-7-9-16(10-8-14)35-23(34)29(2)3/h4,7-10,13,15H,1,5-6,11-12H2,2-3H3,(H,27,33)(H2,24,25,26)/t15-/m1/s1
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n/an/a 26n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376957
PNG
(US9920060, 45)
Show SMILES CN(C)C(=O)Oc1c(Cl)cc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C23H24Cl2N8O4/c1-4-16(34)32-7-5-6-13(10-32)33-21-17(20(26)27-11-28-21)18(30-33)22(35)29-12-8-14(24)19(15(25)9-12)37-23(36)31(2)3/h4,8-9,11,13H,1,5-7,10H2,2-3H3,(H,29,35)(H2,26,27,28)/t13-/m1/s1
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n/an/a 28n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376966
PNG
(US9920060, 54)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(Cl)c1
Show InChI InChI=1S/C23H25ClN8O3/c1-4-17(33)31-8-7-14(11-31)32-22-19(21(25)26-12-27-22)20(29-32)23(35)28-16-6-5-13(9-15(16)24)10-18(34)30(2)3/h4-6,9,12,14H,1,7-8,10-11H2,2-3H3,(H,28,35)(H2,25,26,27)/t14-/m1/s1
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n/an/a 31n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376969
PNG
(US9920060, 57)
Show SMILES COc1c(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc(CC(=O)N(C)C)c1F
Show InChI InChI=1S/C24H27FN8O4/c1-5-16(34)32-9-8-14(11-32)33-23-18(22(26)27-12-28-23)20(30-33)24(36)29-15-7-6-13(10-17(35)31(2)3)19(25)21(15)37-4/h5-7,12,14H,1,8-11H2,2-4H3,(H,29,36)(H2,26,27,28)/t14-/m1/s1
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n/an/a 31n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376975
PNG
(US9920060, 63)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C23H26N8O4/c1-5-17(32)30-9-8-14(11-30)31-21-18(20(24)25-12-26-21)19(28-31)22(33)27-16-7-6-15(10-13(16)2)35-23(34)29(3)4/h5-7,10,12,14H,1,8-9,11H2,2-4H3,(H,27,33)(H2,24,25,26)/t14-/m1/s1
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n/an/a 38n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376930
PNG
(US9920060, 24)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C#N
Show InChI InChI=1S/C26H29N9O3/c1-5-20(36)34-8-6-7-18(13-34)35-25-22(24(28)29-14-30-25)23(32-35)26(38)31-19-10-17(12-27)16(9-15(19)2)11-21(37)33(3)4/h5,9-10,14,18H,1,6-8,11,13H2,2-4H3,(H,31,38)(H2,28,29,30)/t18-/m1/s1
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n/an/a 38n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376958
PNG
(US9920060, 46)
Show SMILES CN(C)C(=O)Oc1c(C)cc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1C
Show InChI InChI=1S/C25H30N8O4/c1-6-18(34)32-9-7-8-17(12-32)33-23-19(22(26)27-13-28-23)20(30-33)24(35)29-16-10-14(2)21(15(3)11-16)37-25(36)31(4)5/h6,10-11,13,17H,1,7-9,12H2,2-5H3,(H,29,35)(H2,26,27,28)/t17-/m1/s1
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n/an/a 44n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376971
PNG
(US9920060, 59)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C
Show InChI InChI=1S/C25H30N8O3/c1-6-19(34)32-10-9-17(12-32)33-24-21(23(26)27-13-28-24)22(30-33)25(36)29-18-8-7-16(14(2)15(18)3)11-20(35)31(4)5/h6-8,13,17H,1,9-12H2,2-5H3,(H,29,36)(H2,26,27,28)/t17-/m1/s1
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n/an/a 45n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376934
PNG
(US9920060, 28)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1
Show InChI InChI=1S/C24H28N8O3/c1-4-18(33)31-11-5-6-17(13-31)32-23-20(22(25)26-14-27-23)21(29-32)24(35)28-16-9-7-15(8-10-16)12-19(34)30(2)3/h4,7-10,14,17H,1,5-6,11-13H2,2-3H3,(H,28,35)(H2,25,26,27)/t17-/m1/s1
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n/an/a 46n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376956
PNG
(US9920060, 44)
Show SMILES CN(C)C(=O)Oc1cc(C)c(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1
Show InChI InChI=1S/C25H30N8O4/c1-6-18(34)32-9-7-8-16(12-32)33-23-19(22(26)27-13-28-23)21(30-33)24(35)29-20-14(2)10-17(11-15(20)3)37-25(36)31(4)5/h6,10-11,13,16H,1,7-9,12H2,2-5H3,(H,29,35)(H2,26,27,28)/t16-/m1/s1
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n/an/a 46n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376928
PNG
(US9920060, 22)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(c1)C1CC1
Show InChI InChI=1S/C27H32N8O3/c1-4-21(36)34-11-5-6-18(14-34)35-26-23(25(28)29-15-30-26)24(32-35)27(38)31-20-10-7-16(13-22(37)33(2)3)12-19(20)17-8-9-17/h4,7,10,12,15,17-18H,1,5-6,8-9,11,13-14H2,2-3H3,(H,31,38)(H2,28,29,30)/t18-/m1/s1
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n/an/a 48n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376976
PNG
(US9920060, 64)
Show SMILES CN(C)C(=O)Oc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c(C)c1C
Show InChI InChI=1S/C24H28N8O4/c1-6-18(33)31-10-9-15(11-31)32-22-19(21(25)26-12-27-22)20(29-32)23(34)28-16-7-8-17(14(3)13(16)2)36-24(35)30(4)5/h6-8,12,15H,1,9-11H2,2-5H3,(H,28,34)(H2,25,26,27)/t15-/m1/s1
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n/an/a 49n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376967
PNG
(US9920060, 55)
Show SMILES COc1c(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)ccc(CC(=O)N(C)C)c1Cl
Show InChI InChI=1S/C24H27ClN8O4/c1-5-16(34)32-9-8-14(11-32)33-23-18(22(26)27-12-28-23)20(30-33)24(36)29-15-7-6-13(10-17(35)31(2)3)19(25)21(15)37-4/h5-7,12,14H,1,8-11H2,2-4H3,(H,29,36)(H2,26,27,28)/t14-/m1/s1
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n/an/a 49n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376959
PNG
(US9920060, 47)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCCN(C3)C(=O)C=C)c3ncnc(N)c23)c(c1)N(C)C
Show InChI InChI=1S/C26H33N9O3/c1-6-20(36)34-11-7-8-17(14-34)35-25-22(24(27)28-15-29-25)23(31-35)26(38)30-18-10-9-16(12-19(18)32(2)3)13-21(37)33(4)5/h6,9-10,12,15,17H,1,7-8,11,13-14H2,2-5H3,(H,30,38)(H2,27,28,29)/t17-/m1/s1
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n/an/a 52n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376973
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-4-amino-N-(4-(2-...)
Show SMILES CN(C)C(=O)Cc1ccc(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)c2ccccc12
Show InChI InChI=1S/C27H28N8O3/c1-4-21(36)34-12-11-17(14-34)35-26-23(25(28)29-15-30-26)24(32-35)27(38)31-20-10-9-16(13-22(37)33(2)3)18-7-5-6-8-19(18)20/h4-10,15,17H,1,11-14H2,2-3H3,(H,31,38)(H2,28,29,30)/t17-/m1/s1
PDB
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n/an/a 59n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM130909
PNG
(US8822500, Stauro- sporine | US9920060, Staurospor...)
Show SMILES CNC1CC2OC(C)(C1OC)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13
Show InChI InChI=1/C28H26N4O3/c1-28-26(34-3)17(29-2)12-20(35-28)31-18-10-6-4-8-14(18)22-23-16(13-30-27(23)33)21-15-9-5-7-11-19(15)32(28)25(21)24(22)31/h4-11,17,20,26,29H,12-13H2,1-3H3,(H,30,33)
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US Patent
n/an/a 63n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376979
PNG
(US9920060, 67)
Show SMILES CN(C)C(=O)Cc1cc(C)c(NC(=O)c2nn([C@@H]3CCN(C3)C(=O)C=C)c3ncnc(N)c23)cc1Cl
Show InChI InChI=1S/C24H27ClN8O3/c1-5-18(34)32-7-6-15(11-32)33-23-20(22(26)27-12-28-23)21(30-33)24(36)29-17-10-16(25)14(8-13(17)2)9-19(35)31(3)4/h5,8,10,12,15H,1,6-7,9,11H2,2-4H3,(H,29,36)(H2,26,27,28)/t15-/m1/s1
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n/an/a 72n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
Receptor tyrosine-protein kinase erbB-2


(Homo sapiens (Human))
BDBM376985
PNG
(US9920060, 73)
Show SMILES Cc1cc(CC(=O)N2CC(O)C2)ccc1NC(=O)c1nn([C@@H]2CCCN(C2)C(=O)C=C)c2ncnc(N)c12
Show InChI InChI=1S/C26H30N8O4/c1-3-20(36)32-8-4-5-17(11-32)34-25-22(24(27)28-14-29-25)23(31-34)26(38)30-19-7-6-16(9-15(19)2)10-21(37)33-12-18(35)13-33/h3,6-7,9,14,17-18,35H,1,4-5,8,10-13H2,2H3,(H,30,38)(H2,27,28,29)/t17-/m1/s1
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n/an/a 74n/an/an/an/an/an/a



TAIHO PHARMACEUTICAL CO., LTD.

US Patent


Assay Description
For the inhibitory activity measurement of each compound, the compound of the present invention or staurosporine was first serially diluted with dime...


US Patent US9920060 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%