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Patent code US9926299

Compile Data Set for Download or QSAR
Found 34 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380418
PNG
(US9926299, 25 (R-isomer))
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H23N5O3/c1-2-19(29)27-13-12-16(14-27)28-22(24)20(23(25)30)21(26-28)15-8-10-18(11-9-15)31-17-6-4-3-5-7-17/h2-11,16H,1,12-14,24H2,(H2,25,30)/t16-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380432
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-5-amino-3-(4-(3,...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cc(F)cc(F)c2)cc1)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H21F2N5O3/c1-2-19(31)29-8-7-16(12-29)30-22(26)20(23(27)32)21(28-30)13-3-5-17(6-4-13)33-18-10-14(24)9-15(25)11-18/h2-6,9-11,16H,1,7-8,12,26H2,(H2,27,32)/t16-/m1/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380438
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-5-amino-3-(4-(2-...)
Show SMILES Cc1ccc(cc1Oc1ccc(cc1)-c1nn([C@@H]2CCN(C2)C(=O)C=C)c(N)c1C(N)=O)[N+]([O-])=O
Show InChI InChI=1S/C24H24N6O5/c1-3-20(31)28-11-10-17(13-28)29-23(25)21(24(26)32)22(27-29)15-5-8-18(9-6-15)35-19-12-16(30(33)34)7-4-14(19)2/h3-9,12,17H,1,10-11,13,25H2,2H3,(H2,26,32)/t17-/m1/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380440
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-5-amino-3-(3-met...)
Show SMILES Cc1cc(ccc1Oc1cccc(c1)[N+]([O-])=O)-c1nn([C@@H]2CCN(C2)C(=O)C=C)c(N)c1C(N)=O
Show InChI InChI=1S/C24H24N6O5/c1-3-20(31)28-10-9-17(13-28)29-23(25)21(24(26)32)22(27-29)15-7-8-19(14(2)11-15)35-18-6-4-5-16(12-18)30(33)34/h3-8,11-12,17H,1,9-10,13,25H2,2H3,(H2,26,32)/t17-/m1/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380057
PNG
(1-(1-acryloylpiperidin-3-yl)-5-amino-3-(4-phenoxyp...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H25N5O3/c1-2-20(30)28-14-6-7-17(15-28)29-23(25)21(24(26)31)22(27-29)16-10-12-19(13-11-16)32-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15,25H2,(H2,26,31)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380421
PNG
(5-amino-3-(4-phenoxyphenyl)-1-(1-(vinylsulfonyl)pi...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)S(=O)(=O)C=C
Show InChI InChI=1S/C23H25N5O4S/c1-2-33(30,31)27-14-6-7-17(15-27)28-22(24)20(23(25)29)21(26-28)16-10-12-19(13-11-16)32-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15,24H2,(H2,25,29)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380430
PNG
((E)-5-amino-1-(2-(4-(dimethylamino)-N-methylbut-2-...)
Show SMILES CN(C)C\C=C\C(=O)N(C)CCn1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H30N6O3/c1-29(2)15-7-10-21(32)30(3)16-17-31-24(26)22(25(27)33)23(28-31)18-11-13-20(14-12-18)34-19-8-5-4-6-9-19/h4-14H,15-17,26H2,1-3H3,(H2,27,33)/b10-7+
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380433
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-5-amino-3-(4-(3-...)
Show SMILES COc1cccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c(N)c2C(N)=O)c1
Show InChI InChI=1S/C24H25N5O4/c1-3-20(30)28-12-11-16(14-28)29-23(25)21(24(26)31)22(27-29)15-7-9-17(10-8-15)33-19-6-4-5-18(13-19)32-2/h3-10,13,16H,1,11-12,14,25H2,2H3,(H2,26,31)/t16-/m1/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380436
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-5-amino-3-(4-(2-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2Cl)cc1)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H22ClN5O3/c1-2-19(30)28-12-11-15(13-28)29-22(25)20(23(26)31)21(27-29)14-7-9-16(10-8-14)32-18-6-4-3-5-17(18)24/h2-10,15H,1,11-13,25H2,(H2,26,31)/t15-/m1/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380425
PNG
(5-amino-1-(2-(N-methylacrylamido)ethyl)-3-(4-pheno...)
Show SMILES CN(CCn1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccccc2)cc1)C(=O)C=C
Show InChI InChI=1S/C22H23N5O3/c1-3-18(28)26(2)13-14-27-21(23)19(22(24)29)20(25-27)15-9-11-17(12-10-15)30-16-7-5-4-6-8-16/h3-12H,1,13-14,23H2,2H3,(H2,24,29)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380429
PNG
(5-amino-1-(2-(2-chloro-N-methylacetamido)ethyl)-3-...)
Show SMILES CN(CCn1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccccc2)cc1)C(=O)CCl
Show InChI InChI=1S/C21H22ClN5O3/c1-26(17(28)13-22)11-12-27-20(23)18(21(24)29)19(25-27)14-7-9-16(10-8-14)30-15-5-3-2-4-6-15/h2-10H,11-13,23H2,1H3,(H2,24,29)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380053
PNG
(5-amino-1-cyclohexyl-3-(4-phenoxyphenyl)-1H-pyrazo...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCCC1
Show InChI InChI=1S/C22H24N4O2/c23-21-19(22(24)27)20(25-26(21)16-7-3-1-4-8-16)15-11-13-18(14-12-15)28-17-9-5-2-6-10-17/h2,5-6,9-14,16H,1,3-4,7-8,23H2,(H2,24,27)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM377832
PNG
(1-[(3S)-1-acryloyl piperidin-3-yl]-5-amino-3-(4-ph...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H25N5O3/c1-2-20(30)28-14-6-7-17(15-28)29-23(25)21(24(26)31)22(27-29)16-10-12-19(13-11-16)32-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15,25H2,(H2,26,31)/t17-/s2
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380427
PNG
(5-amino-1-(2-(N-methylpropiolamido)ethyl)-3-(4-phe...)
Show SMILES CN(CCn1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccccc2)cc1)C(=O)C#C
Show InChI InChI=1S/C22H21N5O3/c1-3-18(28)26(2)13-14-27-21(23)19(22(24)29)20(25-27)15-9-11-17(12-10-15)30-16-7-5-4-6-8-16/h1,4-12H,13-14,23H2,2H3,(H2,24,29)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380015
PNG
((R)-1-(1-acryloylpiperidin-3-yl)-5-(methylamino)-3...)
Show SMILES CNc1c(C(N)=O)c(nn1C1CCCN(C1)C(=O)C=C)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H27N5O3/c1-3-21(31)29-15-7-8-18(16-29)30-25(27-2)22(24(26)32)23(28-30)17-11-13-20(14-12-17)33-19-9-5-4-6-10-19/h3-6,9-14,18,27H,1,7-8,15-16H2,2H3,(H2,26,32)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380071
PNG
(1-(1-acryloylpiperidin-4-yl)-5-amino-3-(4-phenoxyp...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H25N5O3/c1-2-20(30)28-14-12-17(13-15-28)29-23(25)21(24(26)31)22(27-29)16-8-10-19(11-9-16)32-18-6-4-3-5-7-18/h2-11,17H,1,12-15,25H2,(H2,26,31)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380419
PNG
(US9926299, 25 (S-isomer))
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H23N5O3/c1-2-19(29)27-13-12-16(14-27)28-22(24)20(23(25)30)21(26-28)15-8-10-18(11-9-15)31-17-6-4-3-5-7-17/h2-11,16H,1,12-14,24H2,(H2,25,30)/t16-/m0/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380428
PNG
(5-amino-1-(2-(N-methylvinylsulfonamido)ethyl)-3-(4...)
Show SMILES CN(CCn1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccccc2)cc1)S(=O)(=O)C=C
Show InChI InChI=1S/C21H23N5O4S/c1-3-31(28,29)25(2)13-14-26-20(22)18(21(23)27)19(24-26)15-9-11-17(12-10-15)30-16-7-5-4-6-8-16/h3-12H,1,13-14,22H2,2H3,(H2,23,27)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380434
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-5-amino-3-(4-(4-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccc(Cl)cc2)cc1)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H22ClN5O3/c1-2-19(30)28-12-11-16(13-28)29-22(25)20(23(26)31)21(27-29)14-3-7-17(8-4-14)32-18-9-5-15(24)6-10-18/h2-10,16H,1,11-13,25H2,(H2,26,31)/t16-/m1/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380435
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-5-amino-3-(4-(3-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2cccc(c2)C(F)(F)F)cc1)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H22F3N5O3/c1-2-19(33)31-11-10-16(13-31)32-22(28)20(23(29)34)21(30-32)14-6-8-17(9-7-14)35-18-5-3-4-15(12-18)24(25,26)27/h2-9,12,16H,1,10-11,13,28H2,(H2,29,34)/t16-/m1/s1
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n/an/a<100n/an/an/an/an/an/a



Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM303543
PNG
(US10138229, Example 54 | US10266513, Example 127 |...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C24H25N5O3/c1-2-20(30)28-14-6-7-17(15-28)29-23(25)21(24(26)31)22(27-29)16-10-12-19(13-11-16)32-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15,25H2,(H2,26,31)/t17-/s2
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n/an/a<100n/an/an/an/an/an/a



Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380082
PNG
(1-(1-acryloylpyrrolidin-3-yl)-5-amino-3-(4-phenoxy...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H23N5O3/c1-2-19(29)27-13-12-16(14-27)28-22(24)20(23(25)30)21(26-28)15-8-10-18(11-9-15)31-17-6-4-3-5-7-17/h2-11,16H,1,12-14,24H2,(H2,25,30)
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n/an/a<100n/an/an/an/an/an/a



Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380423
PNG
(5-amino-1-(1-(2-chloroacetyl)piperidin-3-yl)-3-(4-...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)CCl
Show InChI InChI=1S/C23H24ClN5O3/c24-13-19(30)28-12-4-5-16(14-28)29-22(25)20(23(26)31)21(27-29)15-8-10-18(11-9-15)32-17-6-2-1-3-7-17/h1-3,6-11,16H,4-5,12-14,25H2,(H2,26,31)
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n/an/a<100n/an/an/an/an/an/a



Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380424
PNG
((E)-5-amino-1-(1-(4-(dimethylamino)but-2-enoyl)pip...)
Show SMILES CN(C)C\C=C\C(=O)N1CCCC(C1)n1nc(c(C(N)=O)c1N)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C27H32N6O3/c1-31(2)16-7-11-23(34)32-17-6-8-20(18-32)33-26(28)24(27(29)35)25(30-33)19-12-14-22(15-13-19)36-21-9-4-3-5-10-21/h3-5,7,9-15,20H,6,8,16-18,28H2,1-2H3,(H2,29,35)/b11-7+
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380437
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-5-amino-3-(4-(4-...)
Show SMILES COc1ccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c(N)c2C(N)=O)cc1
Show InChI InChI=1S/C24H25N5O4/c1-3-20(30)28-13-12-16(14-28)29-23(25)21(24(26)31)22(27-29)15-4-6-18(7-5-15)33-19-10-8-17(32-2)9-11-19/h3-11,16H,1,12-14,25H2,2H3,(H2,26,31)/t16-/m1/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380439
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-5-amino-3-(4-(4-...)
Show SMILES Cc1ccc(Oc2ccc(cc2)-c2nn([C@@H]3CCN(C3)C(=O)C=C)c(N)c2C(N)=O)cc1[N+]([O-])=O
Show InChI InChI=1S/C24H24N6O5/c1-3-20(31)28-11-10-16(13-28)29-23(25)21(24(26)32)22(27-29)15-5-8-17(9-6-15)35-18-7-4-14(2)19(12-18)30(33)34/h3-9,12,16H,1,10-11,13,25H2,2H3,(H2,26,32)/t16-/m1/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380018
PNG
(1-(1-acryloylpiperidin-3-yl)-5-(ethylamino)-3-(4-p...)
Show SMILES CCNc1c(C(N)=O)c(nn1C1CCCN(C1)C(=O)C=C)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H29N5O3/c1-3-22(32)30-16-8-9-19(17-30)31-26(28-4-2)23(25(27)33)24(29-31)18-12-14-21(15-13-18)34-20-10-6-5-7-11-20/h3,5-7,10-15,19,28H,1,4,8-9,16-17H2,2H3,(H2,27,33)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380038
PNG
(1-(1-acryloylpiperidin-3-yl)-5-(2-(4-methylpiperaz...)
Show SMILES CN1CCN(CCNc2c(C(N)=O)c(nn2C2CCCN(C2)C(=O)C=C)-c2ccc(Oc3ccccc3)cc2)CC1
Show InChI InChI=1S/C31H39N7O3/c1-3-27(39)37-16-7-8-24(22-37)38-31(33-15-17-36-20-18-35(2)19-21-36)28(30(32)40)29(34-38)23-11-13-26(14-12-23)41-25-9-5-4-6-10-25/h3-6,9-14,24,33H,1,7-8,15-22H2,2H3,(H2,32,40)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380420
PNG
(5-amino-3-(4-phenoxyphenyl)-1-(1-propioloylpiperid...)
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C#C
Show InChI InChI=1S/C24H23N5O3/c1-2-20(30)28-14-6-7-17(15-28)29-23(25)21(24(26)31)22(27-29)16-10-12-19(13-11-16)32-18-8-4-3-5-9-18/h1,3-5,8-13,17H,6-7,14-15,25H2,(H2,26,31)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380007
PNG
(1-(1-acryloylpiperidin-3-yl)-5-(methylamino)-3-(4-...)
Show SMILES CNc1c(C(N)=O)c(nn1[C@@H]1CCCN(C1)C(=O)C=C)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C25H27N5O3/c1-3-21(31)29-15-7-8-18(16-29)30-25(27-2)22(24(26)32)23(28-30)17-11-13-20(14-12-17)33-19-9-5-4-6-10-19/h3-6,9-14,18,27H,1,7-8,15-16H2,2H3,(H2,26,32)/t18-/m1/s1
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380024
PNG
(1-(1-acryloylpiperidin-3-yl)-5-(2-morpholinoethyla...)
Show SMILES NC(=O)c1c(NCCN2CCOCC2)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C30H36N6O4/c1-2-26(37)35-15-6-7-23(21-35)36-30(32-14-16-34-17-19-39-20-18-34)27(29(31)38)28(33-36)22-10-12-25(13-11-22)40-24-8-4-3-5-9-24/h2-5,8-13,23,32H,1,6-7,14-21H2,(H2,31,38)
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n/an/a<100n/an/an/an/an/an/a



Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM295011
PNG
(US10112922, Compound 1 | US9926299, 27 (R-isomer))
Show SMILES NC(=O)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCCN(C1)S(=O)(=O)C=C
Show InChI InChI=1/C23H25N5O4S/c1-2-33(30,31)27-14-6-7-17(15-27)28-22(24)20(23(25)29)21(26-28)16-10-12-19(13-11-16)32-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15,24H2,(H2,25,29)/t17-/s2
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM303533
PNG
(US10138229, Example 44 | US9926299, 31)
Show SMILES NC(=O)c1c(N)n(CCNC(=O)C=C)nc1-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C21H21N5O3/c1-2-17(27)24-12-13-26-20(22)18(21(23)28)19(25-26)14-8-10-16(11-9-14)29-15-6-4-3-5-7-15/h2-11H,1,12-13,22H2,(H2,23,28)(H,24,27)
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Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM380431
PNG
(1-(1-acryloylpiperidin-3-yl)-5-amino-3-(4-phenoxyp...)
Show SMILES NC(=S)c1c(N)n(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H25N5O2S/c1-2-20(30)28-14-6-7-17(15-28)29-23(25)21(24(26)32)22(27-29)16-10-12-19(13-11-16)31-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15,25H2,(H2,26,32)
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n/an/a<100n/an/an/an/an/an/a



Centaurus BioPharma Co., Ltd.

US Patent


Assay Description
Btk kinase activity was determined using a Homogeneous Time-Resolved Fluorescence (HTRF) methodology (Cisbio). Measurements were performed in a react...


US Patent US9926299 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%