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Patent code US9926301

Compile Data Set for Download or QSAR
Found 28 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380449
PNG
(4-{3-(Cyanomethyl)-3-[3-(hydroxymethyl)-3′-m...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(c(CO)n1)-c1c[nH]nc1C)C(F)(F)F
Show InChI InChI=1/C23H22F5N7O2/c1-12-15(7-30-32-12)16-8-35(33-19(16)9-36)22(3-4-29)10-34(11-22)20-6-17(24)14(5-18(20)25)21(37)31-13(2)23(26,27)28/h5-8,13,36H,3,9-11H2,1-2H3,(H,30,32)(H,31,37)/t13-/s2
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UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380442
PNG
(5-[3-(Cyanomethyl)-3-(3,3′-dimethyl-1H,1R...)
Show SMILES CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1c[nH]nc1C
Show InChI InChI=1S/C21H25N9O/c1-13(2)26-20(31)18-8-24-19(9-23-18)29-11-21(12-29,5-6-22)30-10-17(15(4)28-30)16-7-25-27-14(16)3/h7-10,13H,5,11-12H2,1-4H3,(H,25,27)(H,26,31)
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UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380445
PNG
(5-[3-(Cyanomethyl)-3-(3′,5′-dimethyl-1...)
Show SMILES C[C@H](NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F
Show InChI InChI=1/C21H22F3N9O/c1-12-18(13(2)31-30-12)15-6-28-33(9-15)20(4-5-25)10-32(11-20)17-8-26-16(7-27-17)19(34)29-14(3)21(22,23)24/h6-9,14H,4,10-11H2,1-3H3,(H,29,34)(H,30,31)/t14-/s2
GoogleScholar
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380422
PNG
(4-[3-(Cyanomethyl)-3-(3′-methyl-1H,1′H...)
Show SMILES CC(C)NC(=O)c1ccc(cc1)N1CC(CC#N)(C1)n1cc(cn1)-c1c[nH]nc1C
Show InChI InChI=1S/C22H25N7O/c1-15(2)26-21(30)17-4-6-19(7-5-17)28-13-22(14-28,8-9-23)29-12-18(10-25-29)20-11-24-27-16(20)3/h4-7,10-12,15H,8,13-14H2,1-3H3,(H,24,27)(H,26,30)
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UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380039
PNG
(5-[3-(Cyanomethyl)-3-(3′-methyl-1H,1′H...)
Show SMILES C[C@H](NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1cn[nH]c1C)C(F)(F)F
Show InChI InChI=1/C20H20F3N9O/c1-12-15(6-27-30-12)14-5-28-32(9-14)19(3-4-24)10-31(11-19)17-8-25-16(7-26-17)18(33)29-13(2)20(21,22)23/h5-9,13H,3,10-11H2,1-2H3,(H,27,30)(H,29,33)/t13-/s2
GoogleScholar
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380063
PNG
(5-[3-(Cyanomethyl)-3-(3′-methyl-1H,1′H...)
Show SMILES CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1c[nH]nc1C
Show InChI InChI=1S/C20H23N9O/c1-13(2)26-19(30)17-8-23-18(9-22-17)28-11-20(12-28,4-5-21)29-10-15(6-25-29)16-7-24-27-14(16)3/h6-10,13H,4,11-12H2,1-3H3,(H,24,27)(H,26,30)
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UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380444
PNG
(5-[3-(Cyanomethyl)-3-(3′,5′-dimethyl-1...)
Show SMILES CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C
Show InChI InChI=1S/C21H25N9O/c1-13(2)26-20(31)17-8-24-18(9-23-17)29-11-21(12-29,5-6-22)30-10-16(7-25-30)19-14(3)27-28-15(19)4/h7-10,13H,5,11-12H2,1-4H3,(H,26,31)(H,27,28)
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UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM246853
PNG
(4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F
Show InChI InChI=1/C23H22F5N7O/c1-12-20(13(2)33-32-12)15-8-30-35(9-15)22(4-5-29)10-34(11-22)19-7-17(24)16(6-18(19)25)21(36)31-14(3)23(26,27)28/h6-9,14H,4,10-11H2,1-3H3,(H,31,36)(H,32,33)/t14-/s2
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PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380426
PNG
(4-[3-(Cyanomethyl)-3-(3′-methyl-1H,1′H...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c[nH]nc1C)C(F)(F)F
Show InChI InChI=1/C22H20F5N7O/c1-12-16(8-29-32-12)14-7-30-34(9-14)21(3-4-28)10-33(11-21)19-6-17(23)15(5-18(19)24)20(35)31-13(2)22(25,26)27/h5-9,13H,3,10-11H2,1-2H3,(H,29,32)(H,31,35)/t13-/s2
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UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM246853
PNG
(4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F
Show InChI InChI=1/C23H22F5N7O/c1-12-20(13(2)33-32-12)15-8-30-35(9-15)22(4-5-29)10-34(11-22)19-7-17(24)16(6-18(19)25)21(36)31-14(3)23(26,27)28/h6-9,14H,4,10-11H2,1-3H3,(H,31,36)(H,32,33)/t14-/s2
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PC sid
UniChem
US Patent
n/an/a<300n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380063
PNG
(5-[3-(Cyanomethyl)-3-(3′-methyl-1H,1′H...)
Show SMILES CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1c[nH]nc1C
Show InChI InChI=1S/C20H23N9O/c1-13(2)26-19(30)17-8-23-18(9-22-17)28-11-20(12-28,4-5-21)29-10-15(6-25-29)16-7-24-27-14(16)3/h6-10,13H,4,11-12H2,1-3H3,(H,24,27)(H,26,30)
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UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380446
PNG
(5-[3-(Cyanomethyl)-3-(3-methyl-1H,1′H-4,4...)
Show SMILES CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1cn[nH]c1
Show InChI InChI=1S/C20H23N9O/c1-13(2)26-19(30)17-8-23-18(9-22-17)28-11-20(12-28,4-5-21)29-10-16(14(3)27-29)15-6-24-25-7-15/h6-10,13H,4,11-12H2,1-3H3,(H,24,25)(H,26,30)
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UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380444
PNG
(5-[3-(Cyanomethyl)-3-(3′,5′-dimethyl-1...)
Show SMILES CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C
Show InChI InChI=1S/C21H25N9O/c1-13(2)26-20(31)17-8-24-18(9-23-17)29-11-21(12-29,5-6-22)30-10-16(7-25-30)19-14(3)27-28-15(19)4/h7-10,13H,5,11-12H2,1-4H3,(H,26,31)(H,27,28)
GoogleScholar
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380426
PNG
(4-[3-(Cyanomethyl)-3-(3′-methyl-1H,1′H...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c[nH]nc1C)C(F)(F)F
Show InChI InChI=1/C22H20F5N7O/c1-12-16(8-29-32-12)14-7-30-34(9-14)21(3-4-28)10-33(11-21)19-6-17(23)15(5-18(19)24)20(35)31-13(2)22(25,26)27/h5-9,13H,3,10-11H2,1-2H3,(H,29,32)(H,31,35)/t13-/s2
GoogleScholar
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380441
PNG
(4-[3-(1H,1′H-4,4′-Bipyrazol-1-yl)-3-(c...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1cn[nH]c1)C(F)(F)F
Show InChI InChI=1/C21H18F5N7O/c1-12(21(24,25)26)31-19(34)15-4-17(23)18(5-16(15)22)32-10-20(11-32,2-3-27)33-9-14(8-30-33)13-6-28-29-7-13/h4-9,12H,2,10-11H2,1H3,(H,28,29)(H,31,34)/t12-/s2
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UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380448
PNG
(4-{3-(Cyanomethyl)-3-[3′-(hydroxymethyl)-1H,...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c[nH]nc1CO)C(F)(F)F
Show InChI InChI=1/C22H20F5N7O2/c1-12(22(25,26)27)31-20(36)14-4-17(24)19(5-16(14)23)33-10-21(11-33,2-3-28)34-8-13(6-30-34)15-7-29-32-18(15)9-35/h4-8,12,35H,2,9-11H2,1H3,(H,29,32)(H,31,36)/t12-/s2
GoogleScholar
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM246853
PNG
(4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F
Show InChI InChI=1/C23H22F5N7O/c1-12-20(13(2)33-32-12)15-8-30-35(9-15)22(4-5-29)10-34(11-22)19-7-17(24)16(6-18(19)25)21(36)31-14(3)23(26,27)28/h6-9,14H,4,10-11H2,1-3H3,(H,31,36)(H,32,33)/t14-/s2
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PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK1 (aa 837-1142)


(Homo sapiens (Human))
BDBM380447
PNG
(5-[3-(Cyanomethyl)-3-(3′-ethyl-1H,1′H-...)
Show SMILES CCc1n[nH]cc1-c1cnn(c1)C1(CC#N)CN(C1)c1cnc(cn1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C21H22F3N9O/c1-3-16-15(7-28-31-16)14-6-29-33(10-14)20(4-5-25)11-32(12-20)18-9-26-17(8-27-18)19(34)30-13(2)21(22,23)24/h6-10,13H,3-4,11-12H2,1-2H3,(H,28,31)(H,30,34)/t13-/s2
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UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380445
PNG
(5-[3-(Cyanomethyl)-3-(3′,5′-dimethyl-1...)
Show SMILES C[C@H](NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F
Show InChI InChI=1/C21H22F3N9O/c1-12-18(13(2)31-30-12)15-6-28-33(9-15)20(4-5-25)10-32(11-20)17-8-26-16(7-27-17)19(34)29-14(3)21(22,23)24/h6-9,14H,4,10-11H2,1-3H3,(H,29,34)(H,30,31)/t14-/s2
GoogleScholar
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM246853
PNG
(4-[3-(cyanomethyl)- 3-(3',5'-dimethyl- 1H,...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c(C)n[nH]c1C)C(F)(F)F
Show InChI InChI=1/C23H22F5N7O/c1-12-20(13(2)33-32-12)15-8-30-35(9-15)22(4-5-29)10-34(11-22)19-7-17(24)16(6-18(19)25)21(36)31-14(3)23(26,27)28/h6-9,14H,4,10-11H2,1-3H3,(H,31,36)(H,32,33)/t14-/s2
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 650n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380441
PNG
(4-[3-(1H,1′H-4,4′-Bipyrazol-1-yl)-3-(c...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1cn[nH]c1)C(F)(F)F
Show InChI InChI=1/C21H18F5N7O/c1-12(21(24,25)26)31-19(34)15-4-17(23)18(5-16(15)22)32-10-20(11-32,2-3-27)33-9-14(8-30-33)13-6-28-29-7-13/h4-9,12H,2,10-11H2,1H3,(H,28,29)(H,31,34)/t12-/s2
GoogleScholar
UniChem
US Patent
n/an/a>700n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380422
PNG
(4-[3-(Cyanomethyl)-3-(3′-methyl-1H,1′H...)
Show SMILES CC(C)NC(=O)c1ccc(cc1)N1CC(CC#N)(C1)n1cc(cn1)-c1c[nH]nc1C
Show InChI InChI=1S/C22H25N7O/c1-15(2)26-21(30)17-4-6-19(7-5-17)28-13-22(14-28,8-9-23)29-12-18(10-25-29)20-11-24-27-16(20)3/h4-7,10-12,15H,8,13-14H2,1-3H3,(H,24,27)(H,26,30)
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UniChem
US Patent
n/an/a>700n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380442
PNG
(5-[3-(Cyanomethyl)-3-(3,3′-dimethyl-1H,1R...)
Show SMILES CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1c[nH]nc1C
Show InChI InChI=1S/C21H25N9O/c1-13(2)26-20(31)18-8-24-19(9-23-18)29-11-21(12-29,5-6-22)30-10-17(15(4)28-30)16-7-25-27-14(16)3/h7-10,13H,5,11-12H2,1-4H3,(H,25,27)(H,26,31)
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UniChem
US Patent
n/an/a>700n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380448
PNG
(4-{3-(Cyanomethyl)-3-[3′-(hydroxymethyl)-1H,...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(cn1)-c1c[nH]nc1CO)C(F)(F)F
Show InChI InChI=1/C22H20F5N7O2/c1-12(22(25,26)27)31-20(36)14-4-17(24)19(5-16(14)23)33-10-21(11-33,2-3-28)34-8-13(6-30-34)15-7-29-32-18(15)9-35/h4-8,12,35H,2,9-11H2,1H3,(H,29,32)(H,31,36)/t12-/s2
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UniChem
US Patent
n/an/a>700n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380449
PNG
(4-{3-(Cyanomethyl)-3-[3-(hydroxymethyl)-3′-m...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)n1cc(c(CO)n1)-c1c[nH]nc1C)C(F)(F)F
Show InChI InChI=1/C23H22F5N7O2/c1-12-15(7-30-32-12)16-8-35(33-19(16)9-36)22(3-4-29)10-34(11-22)20-6-17(24)14(5-18(20)25)21(37)31-13(2)23(26,27)28/h5-8,13,36H,3,9-11H2,1-2H3,(H,30,32)(H,31,37)/t13-/s2
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UniChem
US Patent
n/an/a>700n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380446
PNG
(5-[3-(Cyanomethyl)-3-(3-methyl-1H,1′H-4,4...)
Show SMILES CC(C)NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(c(C)n1)-c1cn[nH]c1
Show InChI InChI=1S/C20H23N9O/c1-13(2)26-19(30)17-8-23-18(9-22-17)28-11-20(12-28,4-5-21)29-10-16(14(3)27-29)15-6-24-25-7-15/h6-10,13H,4,11-12H2,1-3H3,(H,24,25)(H,26,30)
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UniChem
US Patent
n/an/a>700n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380447
PNG
(5-[3-(Cyanomethyl)-3-(3′-ethyl-1H,1′H-...)
Show SMILES CCc1n[nH]cc1-c1cnn(c1)C1(CC#N)CN(C1)c1cnc(cn1)C(=O)N[C@@H](C)C(F)(F)F
Show InChI InChI=1/C21H22F3N9O/c1-3-16-15(7-28-31-16)14-6-29-33(10-14)20(4-5-25)11-32(12-20)18-9-26-17(8-27-18)19(34)30-13(2)21(22,23)24/h6-10,13H,3-4,11-12H2,1-2H3,(H,28,31)(H,30,34)/t13-/s2
GoogleScholar
UniChem
US Patent
n/an/a>700n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
JAK2 (aa 828-1132)


(Homo sapiens (Human))
BDBM380039
PNG
(5-[3-(Cyanomethyl)-3-(3′-methyl-1H,1′H...)
Show SMILES C[C@H](NC(=O)c1cnc(cn1)N1CC(CC#N)(C1)n1cc(cn1)-c1cn[nH]c1C)C(F)(F)F
Show InChI InChI=1/C20H20F3N9O/c1-12-15(6-27-30-12)14-5-28-32(9-14)19(3-4-24)10-31(11-19)17-8-25-16(7-26-17)18(33)29-13(2)20(21,22)23/h5-9,13H,3,10-11H2,1-2H3,(H,27,30)(H,29,33)/t13-/s2
GoogleScholar
UniChem
US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Compounds herein were tested for inhibitory activity of JAK targets according to the following in vitro assay described in Park et al., Analytical Bi...


US Patent US9926301 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%