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Patent code US9926330

Compile Data Set for Download or QSAR
Found 55 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380580
PNG
(N'-(6-ethenylquinazolin-4-yl)-N,N- dimethylcyclohe...)
Show SMILES CN(C)C1CCC(CC1)Nc1ncnc2ccc(C=C)cc12
Show InChI InChI=1S/C18H24N4/c1-4-13-5-10-17-16(11-13)18(20-12-19-17)21-14-6-8-15(9-7-14)22(2)3/h4-5,10-12,14-15H,1,6-9H2,2-3H3,(H,19,20,21)
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n/an/a 7n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380582
PNG
(6-ethyl-N-(trans-4-morpholin-4- ylcyclohexyl)quina...)
Show SMILES CCc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C20H28N4O/c1-2-15-3-8-19-18(13-15)20(22-14-21-19)23-16-4-6-17(7-5-16)24-9-11-25-12-10-24/h3,8,13-14,16-17H,2,4-7,9-12H2,1H3,(H,21,22,23)/t16-,17-
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n/an/a 8n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242708
PNG
(CHEMBL4101649 | US9926330, 1-6)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C(F)(F)F
Show InChI InChI=1/C17H21F3N4/c1-24(2)13-6-4-12(5-7-13)23-16-14-9-11(17(18,19)20)3-8-15(14)21-10-22-16/h3,8-10,12-13H,4-7H2,1-2H3,(H,21,22,23)/t12-,13-
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n/an/a 9n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380589
PNG
(3-{4-[(trans-4- morpholin-4- ylcyclohexyl)amino]- ...)
Show SMILES OCCCc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C21H30N4O2/c26-11-1-2-16-3-8-20-19(14-16)21(23-15-22-20)24-17-4-6-18(7-5-17)25-9-12-27-13-10-25/h3,8,14-15,17-18,26H,1-2,4-7,9-13H2,(H,22,23,24)/t17-,18-
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n/an/a 10n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380587
PNG
(N-(trans-4-morpholin-4- ylcyclohexyl)-6- propylqui...)
Show SMILES CCCc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C21H30N4O/c1-2-3-16-4-9-20-19(14-16)21(23-15-22-20)24-17-5-7-18(8-6-17)25-10-12-26-13-11-25/h4,9,14-15,17-18H,2-3,5-8,10-13H2,1H3,(H,22,23,24)/t17-,18-
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n/an/a 11n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380543
PNG
(6-methyl-N-(trans-4-morpholin-4- ylcyclohexyl)quin...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H26N4O/c1-14-2-7-18-17(12-14)19(21-13-20-18)22-15-3-5-16(6-4-15)23-8-10-24-11-9-23/h2,7,12-13,15-16H,3-6,8-11H2,1H3,(H,20,21,22)/t15-,16-
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n/an/a 12n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380544
PNG
(N-(trans-4-morpholin-4-ylcyclohexyl)- 6-(trifluoro...)
Show SMILES FC(F)(F)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H23F3N4O/c20-19(21,22)13-1-6-17-16(11-13)18(24-12-23-17)25-14-2-4-15(5-3-14)26-7-9-27-10-8-26/h1,6,11-12,14-15H,2-5,7-10H2,(H,23,24,25)/t14-,15-
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n/an/a 15n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380585
PNG
(N,N-dimethyl-N'-[6-(1- methylethyl)quinazolin-4- y...)
Show SMILES CC(C)c1ccc2ncnc(NC3CCC(CC3)N(C)C)c2c1
Show InChI InChI=1S/C19H28N4/c1-13(2)14-5-10-18-17(11-14)19(21-12-20-18)22-15-6-8-16(9-7-15)23(3)4/h5,10-13,15-16H,6-9H2,1-4H3,(H,20,21,22)
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n/an/a 16n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380588
PNG
(2-(4-(((trans)-4-(dimethylamino)cyclohexyl)amino)q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(CCO)cc12
Show InChI InChI=1S/C18H26N4O/c1-22(2)15-6-4-14(5-7-15)21-18-16-11-13(9-10-23)3-8-17(16)19-12-20-18/h3,8,11-12,14-15,23H,4-7,9-10H2,1-2H3,(H,19,20,21)/t14-,15-
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n/an/a 17n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380560
PNG
(6-methyl-N-{4- [3- (trifluoromethyl)- piperidin-1-...)
Show SMILES Cc1ccc2ncnc(NC3CCC(CC3)N3CCCC(C3)C(F)(F)F)c2c1
Show InChI InChI=1S/C21H27F3N4/c1-14-4-9-19-18(11-14)20(26-13-25-19)27-16-5-7-17(8-6-16)28-10-2-3-15(12-28)21(22,23)24/h4,9,11,13,15-17H,2-3,5-8,10,12H2,1H3,(H,25,26,27)
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n/an/a 17n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242730
PNG
(CHEMBL4072093 | US9926330, 4-1)
Show SMILES CCc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1/C18H26N4/c1-4-13-5-10-17-16(11-13)18(20-12-19-17)21-14-6-8-15(9-7-14)22(2)3/h5,10-12,14-15H,4,6-9H2,1-3H3,(H,19,20,21)/t14-,15-
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n/an/a 18n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242725
PNG
(CHEMBL4097259 | US9926330, 1-2)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(C)cc12
Show InChI InChI=1/C17H24N4/c1-12-4-9-16-15(10-12)17(19-11-18-16)20-13-5-7-14(8-6-13)21(2)3/h4,9-11,13-14H,5-8H2,1-3H3,(H,18,19,20)/t13-,14-
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n/an/a 19n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380575
PNG
(US9926330, 2-28 | trans-N-(6- methylquinazolin-4-y...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCCC(F)(F)F)c2c1
Show InChI InChI=1S/C18H23F3N4/c1-12-2-7-16-15(10-12)17(24-11-23-16)25-14-5-3-13(4-6-14)22-9-8-18(19,20)21/h2,7,10-11,13-14,22H,3-6,8-9H2,1H3,(H,23,24,25)/t13-,14-
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MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380591
PNG
(1-(4-{[trans-4- (dimethylamino)cyclo- hexyl]amino}...)
Show SMILES CC(O)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C18H26N4O/c1-12(23)13-4-9-17-16(10-13)18(20-11-19-17)21-14-5-7-15(8-6-14)22(2)3/h4,9-12,14-15,23H,5-8H2,1-3H3,(H,19,20,21)/t12?,14-,15-
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n/an/a 29n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380595
PNG
((4-(((trans)-4-(dimethylamino)cyclohexyl)amino)qui...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(CO)cc12
Show InChI InChI=1S/C17H24N4O/c1-21(2)14-6-4-13(5-7-14)20-17-15-9-12(10-22)3-8-16(15)18-11-19-17/h3,8-9,11,13-14,22H,4-7,10H2,1-2H3,(H,18,19,20)/t13-,14-
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n/an/a 29n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380572
PNG
(US9926330, 2-25 | trans-N- (cyclopropylmethyl)-N'-...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCC3CC3)c2c1
Show InChI InChI=1S/C19H26N4/c1-13-2-9-18-17(10-13)19(22-12-21-18)23-16-7-5-15(6-8-16)20-11-14-3-4-14/h2,9-10,12,14-16,20H,3-8,11H2,1H3,(H,21,22,23)/t15-,16-
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n/an/a 31n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380545
PNG
(7-fluoro-6-methyl-N-(trans-4- morpholin-4-ylcycloh...)
Show SMILES Cc1cc2c(N[C@H]3CC[C@@H](CC3)N3CCOCC3)ncnc2cc1F
Show InChI InChI=1S/C19H25FN4O/c1-13-10-16-18(11-17(13)20)21-12-22-19(16)23-14-2-4-15(5-3-14)24-6-8-25-9-7-24/h10-12,14-15H,2-9H2,1H3,(H,21,22,23)/t14-,15-
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n/an/a 32n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380586
PNG
(6-butyl-N-(trans-4- morpholin-4- ylcyclohexyl)quin...)
Show SMILES CCCCc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C22H32N4O/c1-2-3-4-17-5-10-21-20(15-17)22(24-16-23-21)25-18-6-8-19(9-7-18)26-11-13-27-14-12-26/h5,10,15-16,18-19H,2-4,6-9,11-14H2,1H3,(H,23,24,25)/t18-,19-
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n/an/a 34n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380554
PNG
(1-{cis-4-[(6- methylquinazolin- 4- yl)amino]cyclo-...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@H](CC3)N3CC(O)C3)c2c1
Show InChI InChI=1S/C18H24N4O/c1-12-2-7-17-16(8-12)18(20-11-19-17)21-13-3-5-14(6-4-13)22-9-15(23)10-22/h2,7-8,11,13-15,23H,3-6,9-10H2,1H3,(H,19,20,21)/t13-,14+
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n/an/a 37n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380571
PNG
(US9926330, 2-24 | trans-N-(1-methylethyl)- N'-(6-m...)
Show SMILES CC(C)N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(C)cc12
Show InChI InChI=1S/C18H26N4/c1-12(2)21-14-5-7-15(8-6-14)22-18-16-10-13(3)4-9-17(16)19-11-20-18/h4,9-12,14-15,21H,5-8H2,1-3H3,(H,19,20,22)/t14-,15-
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n/an/a 44n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380567
PNG
(US9926330, 2-20 | trans-N-(6- methylquinazolin-4-y...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCc3cccs3)c2c1
Show InChI InChI=1S/C20H24N4S/c1-14-4-9-19-18(11-14)20(23-13-22-19)24-16-7-5-15(6-8-16)21-12-17-3-2-10-25-17/h2-4,9-11,13,15-16,21H,5-8,12H2,1H3,(H,22,23,24)/t15-,16-
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n/an/a 45n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380565
PNG
(US9926330, 2-18 | trans-N-(6- methylquinazolin-4-y...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCC3CCOCC3)c2c1
Show InChI InChI=1S/C21H30N4O/c1-15-2-7-20-19(12-15)21(24-14-23-20)25-18-5-3-17(4-6-18)22-13-16-8-10-26-11-9-16/h2,7,12,14,16-18,22H,3-6,8-11,13H2,1H3,(H,23,24,25)/t17-,18-
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n/an/a 46n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380573
PNG
(US9926330, 2-26 | trans-N-[(1-methyl-1H- pyrazol-5...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCc3ccnn3C)c2c1
Show InChI InChI=1S/C20H26N6/c1-14-3-8-19-18(11-14)20(23-13-22-19)25-16-6-4-15(5-7-16)21-12-17-9-10-24-26(17)2/h3,8-11,13,15-16,21H,4-7,12H2,1-2H3,(H,22,23,25)/t15-,16-
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n/an/a 47n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380566
PNG
(US9926330, 2-19 | trans-N-[(4S)-2,2- dimethyltetra...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NC3CCOC(C)(C)C3)c2c1
Show InChI InChI=1S/C22H32N4O/c1-15-4-9-20-19(12-15)21(24-14-23-20)26-17-7-5-16(6-8-17)25-18-10-11-27-22(2,3)13-18/h4,9,12,14,16-18,25H,5-8,10-11,13H2,1-3H3,(H,23,24,26)/t16-,17-,18?
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n/an/a 54n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380581
PNG
(US9926330, 3-3 | trans-N'-{6-[(1E)-3-methoxyprop- ...)
Show SMILES COC\C=C\c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C20H28N4O/c1-24(2)17-9-7-16(8-10-17)23-20-18-13-15(5-4-12-25-3)6-11-19(18)21-14-22-20/h4-6,11,13-14,16-17H,7-10,12H2,1-3H3,(H,21,22,23)/b5-4+/t16-,17-
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n/an/a 54n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380578
PNG
(US9926330, 2-31 | trans-N-[(1S)-1-methyl-2- (methy...)
Show SMILES CC(CS(C)=O)N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(C)cc12
Show InChI InChI=1S/C19H28N4OS/c1-13-4-9-18-17(10-13)19(21-12-20-18)23-16-7-5-15(6-8-16)22-14(2)11-25(3)24/h4,9-10,12,14-16,22H,5-8,11H2,1-3H3,(H,20,21,23)/t14?,15-,16-,25?
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n/an/a 56n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380594
PNG
(4-(4-(((trans)-4-Morpholinocyclohexyl)amino)quinaz...)
Show SMILES CC(O)CCc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C22H32N4O2/c1-16(27)2-3-17-4-9-21-20(14-17)22(24-15-23-21)25-18-5-7-19(8-6-18)26-10-12-28-13-11-26/h4,9,14-16,18-19,27H,2-3,5-8,10-13H2,1H3,(H,23,24,25)/t16?,18-,19-
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n/an/a 62n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380547
PNG
(US9926330, 1-7)
Show SMILES Cc1ccc2ncnc(O[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H25N3O2/c1-14-2-7-18-17(12-14)19(21-13-20-18)24-16-5-3-15(4-6-16)22-8-10-23-11-9-22/h2,7,12-13,15-16H,3-6,8-11H2,1H3/t15-,16-
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n/an/a 65n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380569
PNG
(US9926330, 2-22 | trans-N-(6- methylquinazolin-4-y...)
Show SMILES CC(CC(F)(F)F)N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(C)cc12
Show InChI InChI=1S/C19H25F3N4/c1-12-3-8-17-16(9-12)18(24-11-23-17)26-15-6-4-14(5-7-15)25-13(2)10-19(20,21)22/h3,8-9,11,13-15,25H,4-7,10H2,1-2H3,(H,23,24,26)/t13?,14-,15-
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n/an/a 67n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380590
PNG
(4-{4-[(trans-4- morpholin-4- ylcyclohexyl)amino]- ...)
Show SMILES OCCCCc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C22H32N4O2/c27-12-2-1-3-17-4-9-21-20(15-17)22(24-16-23-21)25-18-5-7-19(8-6-18)26-10-13-28-14-11-26/h4,9,15-16,18-19,27H,1-3,5-8,10-14H2,(H,23,24,25)/t18-,19-
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n/an/a 68n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380576
PNG
(US9926330, 2-29 | trans-N-(2,2- dimethylpropyl)-N'...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCC(C)(C)C)c2c1
Show InChI InChI=1S/C20H30N4/c1-14-5-10-18-17(11-14)19(23-13-22-18)24-16-8-6-15(7-9-16)21-12-20(2,3)4/h5,10-11,13,15-16,21H,6-9,12H2,1-4H3,(H,22,23,24)/t15-,16-
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n/an/a 69n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380568
PNG
(US9926330, 2-21 | trans-N-[(1S)-1- cyclopropylethy...)
Show SMILES CC(N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(C)cc12)C1CC1
Show InChI InChI=1S/C20H28N4/c1-13-3-10-19-18(11-13)20(22-12-21-19)24-17-8-6-16(7-9-17)23-14(2)15-4-5-15/h3,10-12,14-17,23H,4-9H2,1-2H3,(H,21,22,24)/t14?,16-,17-
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n/an/a 73n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380574
PNG
(US9926330, 2-27 | trans-N-[(3-methyloxetan- 3-yl)m...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NCC3(C)COC3)c2c1
Show InChI InChI=1S/C20H28N4O/c1-14-3-8-18-17(9-14)19(23-13-22-18)24-16-6-4-15(5-7-16)21-10-20(2)11-25-12-20/h3,8-9,13,15-16,21H,4-7,10-12H2,1-2H3,(H,22,23,24)/t15-,16-
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n/an/a 77n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380564
PNG
((trans)-N1-(6-methylquinazolin-4-yl)-N4-(tetrahydr...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NC3CCOCC3)c2c1
Show InChI InChI=1S/C20H28N4O/c1-14-2-7-19-18(12-14)20(22-13-21-19)24-16-5-3-15(4-6-16)23-17-8-10-25-11-9-17/h2,7,12-13,15-17,23H,3-6,8-11H2,1H3,(H,21,22,24)/t15-,16-
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n/an/a 77n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380558
PNG
(6-methyl-N-{4- [4- (trifluoromethyl)- piperidin-1-...)
Show SMILES Cc1ccc2ncnc(NC3CCC(CC3)N3CCC(CC3)C(F)(F)F)c2c1
Show InChI InChI=1S/C21H27F3N4/c1-14-2-7-19-18(12-14)20(26-13-25-19)27-16-3-5-17(6-4-16)28-10-8-15(9-11-28)21(22,23)24/h2,7,12-13,15-17H,3-6,8-11H2,1H3,(H,25,26,27)
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n/an/a 88n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380550
PNG
(N-[trans-4-(3- fluoroazetidin-1- yl)cyclohexyl]-6-...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CC(F)C3)c2c1
Show InChI InChI=1S/C18H23FN4/c1-12-2-7-17-16(8-12)18(21-11-20-17)22-14-3-5-15(6-4-14)23-9-13(19)10-23/h2,7-8,11,13-15H,3-6,9-10H2,1H3,(H,20,21,22)/t14-,15-
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n/an/a 94n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380556
PNG
(6-methyl-N- [trans-4-(2-oxa-6- azaspiro[3.4]oct- 6...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC4(COC4)C3)c2c1
Show InChI InChI=1S/C21H28N4O/c1-15-2-7-19-18(10-15)20(23-14-22-19)24-16-3-5-17(6-4-16)25-9-8-21(11-25)12-26-13-21/h2,7,10,14,16-17H,3-6,8-9,11-13H2,1H3,(H,22,23,24)/t16-,17-
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n/an/a 95n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380593
PNG
(N-((trans)-4-(2-oxa-6-azaspiro[3.3]heptan-6-yl)cyc...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CC4(COC4)C3)c2c1
Show InChI InChI=1S/C20H26N4O/c1-14-2-7-18-17(8-14)19(22-13-21-18)23-15-3-5-16(6-4-15)24-9-20(10-24)11-25-12-20/h2,7-8,13,15-16H,3-6,9-12H2,1H3,(H,21,22,23)/t15-,16-
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n/an/a 101n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380552
PNG
(4-{trans-4-[(6- methylquinazolin- 4- yl)amino]cycl...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCNC(=O)C3)c2c1
Show InChI InChI=1S/C19H25N5O/c1-13-2-7-17-16(10-13)19(22-12-21-17)23-14-3-5-15(6-4-14)24-9-8-20-18(25)11-24/h2,7,10,12,14-15H,3-6,8-9,11H2,1H3,(H,20,25)(H,21,22,23)/t14-,15-
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n/an/a 113n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380570
PNG
((3S)-2-methyl-3-({trans-4- [(6-methylquinazolin-4-...)
Show SMILES CC(N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(C)cc12)C(C)(C)O
Show InChI InChI=1S/C20H30N4O/c1-13-5-10-18-17(11-13)19(22-12-21-18)24-16-8-6-15(7-9-16)23-14(2)20(3,4)25/h5,10-12,14-16,23,25H,6-9H2,1-4H3,(H,21,22,24)/t14?,15-,16-
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n/an/a 123n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380577
PNG
(US9926330, 2-30 | trans-N-[(1S)-2,2-difluoro- 1-me...)
Show SMILES CC(N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(C)cc12)C(F)F
Show InChI InChI=1S/C18H24F2N4/c1-11-3-8-16-15(9-11)18(22-10-21-16)24-14-6-4-13(5-7-14)23-12(2)17(19)20/h3,8-10,12-14,17,23H,4-7H2,1-2H3,(H,21,22,24)/t12?,13-,14-
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n/an/a 126n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380583
PNG
(4-(4-(((trans)-4-morpholinocyclohexyl)amino)quinaz...)
Show SMILES N#CCCCc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C22H29N5O/c23-10-2-1-3-17-4-9-21-20(15-17)22(25-16-24-21)26-18-5-7-19(8-6-18)27-11-13-28-14-12-27/h4,9,15-16,18-19H,1-3,5-8,11-14H2,(H,24,25,26)/t18-,19-
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n/an/a 142n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380579
PNG
((trans)-N1-(6-((E)-2-cyclopropylvinyl)quinazolin-4...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(\C=C\C3CC3)cc12
Show InChI InChI=1S/C21H28N4/c1-25(2)18-10-8-17(9-11-18)24-21-19-13-16(6-5-15-3-4-15)7-12-20(19)22-14-23-21/h5-7,12-15,17-18H,3-4,8-11H2,1-2H3,(H,22,23,24)/b6-5+/t17-,18-
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n/an/a 145n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380555
PNG
(N-[trans-4-(3,3- difluoropyrrolidin- 1-yl)cyclohex...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)(F)C3)c2c1
Show InChI InChI=1S/C19H24F2N4/c1-13-2-7-17-16(10-13)18(23-12-22-17)24-14-3-5-15(6-4-14)25-9-8-19(20,21)11-25/h2,7,10,12,14-15H,3-6,8-9,11H2,1H3,(H,22,23,24)/t14-,15-
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n/an/a 234n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380560
PNG
(6-methyl-N-{4- [3- (trifluoromethyl)- piperidin-1-...)
Show SMILES Cc1ccc2ncnc(NC3CCC(CC3)N3CCCC(C3)C(F)(F)F)c2c1
Show InChI InChI=1S/C21H27F3N4/c1-14-4-9-19-18(11-14)20(26-13-25-19)27-16-5-7-17(8-6-16)28-10-2-3-15(12-28)21(22,23)24/h4,9,11,13,15-17H,2-3,5-8,10,12H2,1H3,(H,25,26,27)
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n/an/a 269n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380548
PNG
(6-methyl-N-((1R,4R)-4-(3-(methylsulfonyl)azetidin-...)
Show SMILES Cc1ccc2ncnc(NC3CC[C@@H](CC3)N3CC(C3)S(C)(=O)=O)c2c1
Show InChI InChI=1S/C19H26N4O2S/c1-13-3-8-18-17(9-13)19(21-12-20-18)22-14-4-6-15(7-5-14)23-10-16(11-23)26(2,24)25/h3,8-9,12,14-16H,4-7,10-11H2,1-2H3,(H,20,21,22)/t14?,15-
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n/an/a 384n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380557
PNG
(6-methyl-N-{cis- 4-[3- (methylsulfonyl)- azetidin-...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@H](CC3)N3CC(C3)S(C)(=O)=O)c2c1
Show InChI InChI=1S/C19H26N4O2S/c1-13-3-8-18-17(9-13)19(21-12-20-18)22-14-4-6-15(7-5-14)23-10-16(11-23)26(2,24)25/h3,8-9,12,14-16H,4-7,10-11H2,1-2H3,(H,20,21,22)/t14-,15+
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n/an/a 384n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380592
PNG
(4-((trans)-4-(((6-methylquinazolin-4-yl)amino)cycl...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCS(=O)(=O)CC3)c2c1
Show InChI InChI=1S/C19H26N4O2S/c1-14-2-7-18-17(12-14)19(21-13-20-18)22-15-3-5-16(6-4-15)23-8-10-26(24,25)11-9-23/h2,7,12-13,15-16H,3-6,8-11H2,1H3,(H,20,21,22)/t15-,16-
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n/an/a 623n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242703
PNG
(CHEMBL4069378 | US9926330, 1-1)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2cc(C)c(C)cc12
Show InChI InChI=1/C18H26N4/c1-12-9-16-17(10-13(12)2)19-11-20-18(16)21-14-5-7-15(8-6-14)22(3)4/h9-11,14-15H,5-8H2,1-4H3,(H,19,20,21)/t14-,15-
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US Patent
n/an/a 1.21E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380549
PNG
(N-[cis-4-(3- fluoroazetidin-1- yl)cyclohexyl]-6- m...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@H](CC3)N3CC(F)C3)c2c1
Show InChI InChI=1S/C18H23FN4/c1-12-2-7-17-16(8-12)18(21-11-20-17)22-14-3-5-15(6-4-14)23-9-13(19)10-23/h2,7-8,11,13-15H,3-6,9-10H2,1H3,(H,20,21,22)/t14-,15+
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n/an/a 1.37E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380561
PNG
(6-methyl-N-{4- [2- (trifluoromethyl)- piperidin-1-...)
Show SMILES Cc1ccc2ncnc(NC3CCC(CC3)N3CCCCC3C(F)(F)F)c2c1
Show InChI InChI=1S/C21H27F3N4/c1-14-5-10-18-17(12-14)20(26-13-25-18)27-15-6-8-16(9-7-15)28-11-3-2-4-19(28)21(22,23)24/h5,10,12-13,15-16,19H,2-4,6-9,11H2,1H3,(H,25,26,27)
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n/an/a 1.76E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380551
PNG
(4-{cis-4-[(6- methylquinazolin- 4- yl)amino]cyclo-...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@H](CC3)N3CCNC(=O)C3)c2c1
Show InChI InChI=1S/C19H25N5O/c1-13-2-7-17-16(10-13)19(22-12-21-17)23-14-3-5-15(6-4-14)24-9-8-20-18(25)11-24/h2,7,10,12,14-15H,3-6,8-9,11H2,1H3,(H,20,25)(H,21,22,23)/t14-,15+
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n/an/a 2.20E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380553
PNG
(1-{trans-4-[(6- methylquinazolin- 4- yl)amino]cycl...)
Show SMILES Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CC(O)C3)c2c1
Show InChI InChI=1S/C18H24N4O/c1-12-2-7-17-16(8-12)18(20-11-19-17)21-13-3-5-14(6-4-13)22-9-15(23)10-22/h2,7-8,11,13-15,23H,3-6,9-10H2,1H3,(H,19,20,21)/t13-,14-
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n/an/a 2.35E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380561
PNG
(6-methyl-N-{4- [2- (trifluoromethyl)- piperidin-1-...)
Show SMILES Cc1ccc2ncnc(NC3CCC(CC3)N3CCCCC3C(F)(F)F)c2c1
Show InChI InChI=1S/C21H27F3N4/c1-14-5-10-18-17(12-14)20(26-13-25-18)27-15-6-8-16(9-7-15)28-11-3-2-4-19(28)21(22,23)24/h5,10,12-13,15-16,19H,2-4,6-9,11H2,1H3,(H,25,26,27)
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n/an/a 3.23E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM380559
PNG
(6-methyl-N-{4- [4- (trifluoromethyl)- piperidin-1-...)
Show SMILES Cc1ccc2ncnc(NC3CCC(CC3)N3CCC(CC3)C(F)(F)F)c2c1
Show InChI InChI=1S/C21H27F3N4/c1-14-2-7-19-18(12-14)20(26-13-25-19)27-16-3-5-17(6-4-16)28-10-8-15(9-11-28)21(22,23)24/h2,7,12-13,15-17H,3-6,8-11H2,1H3,(H,25,26,27)
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n/an/a 9.38E+3n/an/an/an/an/an/a



MERCK SHARP & DOHME CORP.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9926330 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%