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Patent code US9931340

Compile Data Set for Download or QSAR
Found 68 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210775
PNG
(US9290456, 4 | US9931340, Example 4)
Show SMILES Oc1cc(SCc2ccc(Cl)cc2)n[nH]c1=O
Show InChI InChI=1S/C11H9ClN2O2S/c12-8-3-1-7(2-4-8)6-17-10-5-9(15)11(16)14-13-10/h1-5H,6H2,(H,13,15)(H,14,16)
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n/an/a 3.70n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210789
PNG
(US9290456, 24 | US9931340, Example 24)
Show SMILES Cc1cc(CCc2cc(O)c(=O)[nH]n2)ccc1F
Show InChI InChI=1S/C13H13FN2O2/c1-8-6-9(3-5-11(8)14)2-4-10-7-12(17)13(18)16-15-10/h3,5-7H,2,4H2,1H3,(H,15,17)(H,16,18)
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n/an/a 6n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210785
PNG
(US9290456, 20 | US9931340, Example 20)
Show SMILES Oc1cc(CCc2cccc(Cl)c2)n[nH]c1=O
Show InChI InChI=1S/C12H11ClN2O2/c13-9-3-1-2-8(6-9)4-5-10-7-11(16)12(17)15-14-10/h1-3,6-7H,4-5H2,(H,14,16)(H,15,17)
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n/an/a 8.40n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431067
PNG
(CHEMBL2338797 | US10202399, Example 18 | US9212147...)
Show SMILES Oc1cc(CCc2cccc(F)c2)n[nH]c1=O
Show InChI InChI=1S/C12H11FN2O2/c13-9-3-1-2-8(6-9)4-5-10-7-11(16)12(17)15-14-10/h1-3,6-7H,4-5H2,(H,14,16)(H,15,17)
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n/an/a 9.70n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210777
PNG
(US9290456, 9 | US9931340, Example 9)
Show SMILES Oc1cc(CCc2ccc(F)c(F)c2)n[nH]c1=O
Show InChI InChI=1S/C12H10F2N2O2/c13-9-4-2-7(5-10(9)14)1-3-8-6-11(17)12(18)16-15-8/h2,4-6H,1,3H2,(H,15,17)(H,16,18)
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n/an/a 10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431086
PNG
(CHEMBL2338800 | US10202399, Example 212 | US921214...)
Show SMILES Oc1cc(CCc2ccc(F)cc2)n[nH]c1=O
Show InChI InChI=1S/C12H11FN2O2/c13-9-4-1-8(2-5-9)3-6-10-7-11(16)12(17)15-14-10/h1-2,4-5,7H,3,6H2,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431078
PNG
(CHEMBL2338786 | US9290456, 1 | US9931340, Example ...)
Show SMILES Oc1cc(CCc2ccccc2)n[nH]c1=O
Show InChI InChI=1S/C12H12N2O2/c15-11-8-10(13-14-12(11)16)7-6-9-4-2-1-3-5-9/h1-5,8H,6-7H2,(H,13,15)(H,14,16)
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n/an/a 10n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210827
PNG
(US9290456, 67 | US9931340, Example 67)
Show SMILES Oc1cc(CCc2cc(F)c(c(F)c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H9F5N2O2/c14-8-3-6(4-9(15)11(8)13(16,17)18)1-2-7-5-10(21)12(22)20-19-7/h3-5H,1-2H2,(H,19,21)(H,20,22)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431083
PNG
(CHEMBL2338803 | US10202399, Example 24 | US9212147...)
Show SMILES Oc1cc(CCc2cc(F)cc(F)c2)n[nH]c1=O
Show InChI InChI=1S/C12H10F2N2O2/c13-8-3-7(4-9(14)5-8)1-2-10-6-11(17)12(18)16-15-10/h3-6H,1-2H2,(H,15,17)(H,16,18)
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n/an/a 11n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210826
PNG
(US9290456, 66 | US9931340, Example 66)
Show SMILES Cc1cc(ccc1CCc1cc(O)c(=O)[nH]n1)C(F)(F)F
Show InChI InChI=1S/C14H13F3N2O2/c1-8-6-10(14(15,16)17)4-2-9(8)3-5-11-7-12(20)13(21)19-18-11/h2,4,6-7H,3,5H2,1H3,(H,18,20)(H,19,21)
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n/an/a 12n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210802
PNG
(US9290456, 40 | US9931340, Example 40)
Show SMILES Oc1cc(Cc2ccc(Cl)cc2)n[nH]c1=O
Show InChI InChI=1S/C11H9ClN2O2/c12-8-3-1-7(2-4-8)5-9-6-10(15)11(16)14-13-9/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210784
PNG
(US9290456, 19 | US9931340, Example 19)
Show SMILES Oc1cc(Cc2ccccc2)n[nH]c1=O
Show InChI InChI=1S/C11H10N2O2/c14-10-7-9(12-13-11(10)15)6-8-4-2-1-3-5-8/h1-5,7H,6H2,(H,12,14)(H,13,15)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210810
PNG
(US9290456, 48 | US9931340, Example 48)
Show SMILES Cc1cccc(Cc2cc(O)c(=O)[nH]n2)c1
Show InChI InChI=1S/C12H12N2O2/c1-8-3-2-4-9(5-8)6-10-7-11(15)12(16)14-13-10/h2-5,7H,6H2,1H3,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210801
PNG
(US9290456, 39 | US9931340, Example 39)
Show SMILES Oc1cc(Cc2cccc(Cl)c2)n[nH]c1=O
Show InChI InChI=1S/C11H9ClN2O2/c12-8-3-1-2-7(4-8)5-9-6-10(15)11(16)14-13-9/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210824
PNG
(US9290456, 64 | US9931340, Example 64)
Show SMILES Cc1cc(CCc2cc(O)c(=O)[nH]n2)ccc1C(F)(F)F
Show InChI InChI=1S/C14H13F3N2O2/c1-8-6-9(3-5-11(8)14(15,16)17)2-4-10-7-12(20)13(21)19-18-10/h3,5-7H,2,4H2,1H3,(H,18,20)(H,19,21)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210787
PNG
(US9290456, 22 | US9931340, Example 22)
Show SMILES Oc1cc(CCc2ccc(cc2)C#N)n[nH]c1=O
Show InChI InChI=1S/C13H11N3O2/c14-8-10-3-1-9(2-4-10)5-6-11-7-12(17)13(18)16-15-11/h1-4,7H,5-6H2,(H,15,17)(H,16,18)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431069
PNG
(CHEMBL2338795 | US10202399, Example 27 | US9212147...)
Show SMILES Oc1cc(CCc2ccccc2F)n[nH]c1=O
Show InChI InChI=1S/C12H11FN2O2/c13-10-4-2-1-3-8(10)5-6-9-7-11(16)12(17)15-14-9/h1-4,7H,5-6H2,(H,14,16)(H,15,17)
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n/an/a 13n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM196661
PNG
(US10202399, Example 21 | US9212147, 21 | US9290456...)
Show SMILES Oc1cc(CCc2ccc(F)cc2F)n[nH]c1=O
Show InChI InChI=1S/C12H10F2N2O2/c13-8-3-1-7(10(14)5-8)2-4-9-6-11(17)12(18)16-15-9/h1,3,5-6H,2,4H2,(H,15,17)(H,16,18)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210825
PNG
(US9290456, 65 | US9931340, Example 65)
Show SMILES Oc1cc(CCc2ccc(c(Cl)c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H10ClF3N2O2/c14-10-5-7(2-4-9(10)13(15,16)17)1-3-8-6-11(20)12(21)19-18-8/h2,4-6H,1,3H2,(H,18,20)(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431074
PNG
(CHEMBL2338790 | US9212147, 254 | US9290456, 27 | U...)
Show SMILES Oc1cc(CCc2ccc(Cl)cc2)n[nH]c1=O
Show InChI InChI=1S/C12H11ClN2O2/c13-9-4-1-8(2-5-9)3-6-10-7-11(16)12(17)15-14-10/h1-2,4-5,7H,3,6H2,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210783
PNG
(US9290456, 18 | US9931340, Example 18)
Show SMILES Oc1cc(CCc2cccc(c2)C(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H12F2N2O2/c14-12(15)9-3-1-2-8(6-9)4-5-10-7-11(18)13(19)17-16-10/h1-3,6-7,12H,4-5H2,(H,16,18)(H,17,19)
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210816
PNG
(US9290456, 54 | US9931340, Example 54)
Show SMILES Oc1cc(CCc2c(F)cccc2Cl)n[nH]c1=O
Show InChI InChI=1S/C12H10ClFN2O2/c13-9-2-1-3-10(14)8(9)5-4-7-6-11(17)12(18)16-15-7/h1-3,6H,4-5H2,(H,15,17)(H,16,18)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210788
PNG
(US9290456, 23 | US9931340, Example 23)
Show SMILES Cc1ccc(CCc2cc(O)c(=O)[nH]n2)cc1F
Show InChI InChI=1S/C13H13FN2O2/c1-8-2-3-9(6-11(8)14)4-5-10-7-12(17)13(18)16-15-10/h2-3,6-7H,4-5H2,1H3,(H,15,17)(H,16,18)
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n/an/a 14n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210823
PNG
(US9290456, 63 | US9931340, Example 63)
Show SMILES Oc1cc(CCc2ccc(c(c2)C(F)(F)F)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C14H10F6N2O2/c15-13(16,17)9-4-2-7(5-10(9)14(18,19)20)1-3-8-6-11(23)12(24)22-21-8/h2,4-6H,1,3H2,(H,21,23)(H,22,24)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210808
PNG
(US9290456, 46 | US9931340, Example 46)
Show SMILES Oc1cc(Cc2ccccc2F)n[nH]c1=O
Show InChI InChI=1S/C11H9FN2O2/c12-9-4-2-1-3-7(9)5-8-6-10(15)11(16)14-13-8/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210821
PNG
(US9290456, 60 | US9931340, Example 60)
Show SMILES Oc1cc(CCc2ccc(cc2F)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H10F4N2O2/c14-10-5-8(13(15,16)17)3-1-7(10)2-4-9-6-11(20)12(21)19-18-9/h1,3,5-6H,2,4H2,(H,18,20)(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210804
PNG
(US9290456, 42 | US9931340, Example 42)
Show SMILES Oc1cc(Cc2ccc(F)cc2)n[nH]c1=O
Show InChI InChI=1S/C11H9FN2O2/c12-8-3-1-7(2-4-8)5-9-6-10(15)11(16)14-13-9/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210795
PNG
(US9290456, 32 | US9931340, Example 32)
Show SMILES Oc1cc(CCc2cccc(OC(F)F)c2)n[nH]c1=O
Show InChI InChI=1S/C13H12F2N2O3/c14-13(15)20-10-3-1-2-8(6-10)4-5-9-7-11(18)12(19)17-16-9/h1-3,6-7,13H,4-5H2,(H,16,18)(H,17,19)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431066
PNG
(CHEMBL2338798 | US10202399, Example 17 | US9212147...)
Show SMILES Oc1cc(CCc2cccc(c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O2/c14-13(15,16)9-3-1-2-8(6-9)4-5-10-7-11(19)12(20)18-17-10/h1-3,6-7H,4-5H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210781
PNG
(US9290456, 15 | US9931340, Example 15)
Show SMILES Oc1cc(CCC2CCCC2)n[nH]c1=O
Show InChI InChI=1S/C11H16N2O2/c14-10-7-9(12-13-11(10)15)6-5-8-3-1-2-4-8/h7-8H,1-6H2,(H,12,14)(H,13,15)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210807
PNG
(US9290456, 45 | US9931340, Example 45)
Show SMILES Oc1cc(Cc2cccc(F)c2)n[nH]c1=O
Show InChI InChI=1S/C11H9FN2O2/c12-8-3-1-2-7(4-8)5-9-6-10(15)11(16)14-13-9/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210793
PNG
(US9290456, 30 | US9931340, Example 30)
Show SMILES Oc1cc(CCc2ccc(OC(F)F)cc2)n[nH]c1=O
Show InChI InChI=1S/C13H12F2N2O3/c14-13(15)20-10-5-2-8(3-6-10)1-4-9-7-11(18)12(19)17-16-9/h2-3,5-7,13H,1,4H2,(H,16,18)(H,17,19)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210820
PNG
(US9290456, 59 | US9931340, Example 59)
Show SMILES Oc1cc(CCc2ccc(cc2Cl)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H10ClF3N2O2/c14-10-5-8(13(15,16)17)3-1-7(10)2-4-9-6-11(20)12(21)19-18-9/h1,3,5-6H,2,4H2,(H,18,20)(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210828
PNG
(US9290456, 68 | US9931340, Example 68)
Show SMILES Oc1cc(CCc2ccc(c(F)c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H10F4N2O2/c14-10-5-7(2-4-9(10)13(15,16)17)1-3-8-6-11(20)12(21)19-18-8/h2,4-6H,1,3H2,(H,18,20)(H,19,21)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431085
PNG
(CHEMBL2338801 | US10202399, Example 12 | US9212147...)
Show SMILES Oc1cc(CCc2ccc(cc2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O2/c14-13(15,16)9-4-1-8(2-5-9)3-6-10-7-11(19)12(20)18-17-10/h1-2,4-5,7H,3,6H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210815
PNG
(US9290456, 53 | US9931340, Example 53)
Show SMILES Oc1cc(CCc2c(F)cccc2F)n[nH]c1=O
Show InChI InChI=1S/C12H10F2N2O2/c13-9-2-1-3-10(14)8(9)5-4-7-6-11(17)12(18)16-15-7/h1-3,6H,4-5H2,(H,15,17)(H,16,18)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210794
PNG
(US10202399, Example 28 | US9290456, 31 | US9931340...)
Show SMILES Oc1cc(CCc2ccc(OC(F)(F)F)cc2)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O3/c14-13(15,16)21-10-5-2-8(3-6-10)1-4-9-7-11(19)12(20)18-17-9/h2-3,5-7H,1,4H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210800
PNG
(US9290456, 38 | US9931340, Example 38)
Show SMILES CN(CC1CCCCC1)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1S/C12H19N3O2/c1-15(8-9-5-3-2-4-6-9)11-7-10(16)12(17)14-13-11/h7,9H,2-6,8H2,1H3,(H,13,16)(H,14,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210792
PNG
(US9290456, 28 | US9931340, Example 28)
Show SMILES Oc1cc(CCc2ccccc2Cl)n[nH]c1=O
Show InChI InChI=1S/C12H11ClN2O2/c13-10-4-2-1-3-8(10)5-6-9-7-11(16)12(17)15-14-9/h1-4,7H,5-6H2,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210786
PNG
(US9290456, 21 | US9931340, Example 21)
Show SMILES Oc1cc(n[nH]c1=O)C1(CC1)c1ccccc1
Show InChI InChI=1S/C13H12N2O2/c16-10-8-11(14-15-12(10)17)13(6-7-13)9-4-2-1-3-5-9/h1-5,8H,6-7H2,(H,14,16)(H,15,17)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210773
PNG
(US9290456, 3 | US9931340, Example 3)
Show SMILES Oc1cc(CCc2ccc(cn2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C12H10F3N3O2/c13-12(14,15)7-1-2-8(16-6-7)3-4-9-5-10(19)11(20)18-17-9/h1-2,5-6H,3-4H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210778
PNG
(US9290456, 10 | US9290456, 26 | US9931340, Example...)
Show SMILES Oc1cc(CCc2cccc(OC(F)(F)F)c2)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O3/c14-13(15,16)21-10-3-1-2-8(6-10)4-5-9-7-11(19)12(20)18-17-9/h1-3,6-7H,4-5H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210778
PNG
(US9290456, 10 | US9290456, 26 | US9931340, Example...)
Show SMILES Oc1cc(CCc2cccc(OC(F)(F)F)c2)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O3/c14-13(15,16)21-10-3-1-2-8(6-10)4-5-9-7-11(19)12(20)18-17-9/h1-3,6-7H,4-5H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210806
PNG
(US9290456, 44 | US9931340, Example 44)
Show SMILES Oc1cc(Cc2ccccc2Cl)n[nH]c1=O
Show InChI InChI=1S/C11H9ClN2O2/c12-9-4-2-1-3-7(9)5-8-6-10(15)11(16)14-13-8/h1-4,6H,5H2,(H,13,15)(H,14,16)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210796
PNG
(US9290456, 33 | US9931340, Example 33)
Show SMILES Oc1cc(n[nH]c1=O)C1(CC1)c1ccc(F)cc1
Show InChI InChI=1S/C13H11FN2O2/c14-9-3-1-8(2-4-9)13(5-6-13)11-7-10(17)12(18)16-15-11/h1-4,7H,5-6H2,(H,15,17)(H,16,18)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210811
PNG
(US9290456, 49 | US9931340, Example 49)
Show SMILES Oc1cc(Cc2cccc(c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C12H9F3N2O2/c13-12(14,15)8-3-1-2-7(4-8)5-9-6-10(18)11(19)17-16-9/h1-4,6H,5H2,(H,16,18)(H,17,19)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210779
PNG
(US9290456, 12 | US9290456, 50 | US9931340, Example...)
Show SMILES Oc1cc(CCc2cncc(c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C12H10F3N3O2/c13-12(14,15)8-3-7(5-16-6-8)1-2-9-4-10(19)11(20)18-17-9/h3-6H,1-2H2,(H,17,19)(H,18,20)
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210779
PNG
(US9290456, 12 | US9290456, 50 | US9931340, Example...)
Show SMILES Oc1cc(CCc2cncc(c2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C12H10F3N3O2/c13-12(14,15)8-3-7(5-16-6-8)1-2-9-4-10(19)11(20)18-17-9/h3-6H,1-2H2,(H,17,19)(H,18,20)
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n/an/a 23n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210805
PNG
(US9290456, 43 | US9931340, Example 43)
Show SMILES Oc1cc(Cc2c(F)cccc2Cl)n[nH]c1=O
Show InChI InChI=1S/C11H8ClFN2O2/c12-8-2-1-3-9(13)7(8)4-6-5-10(16)11(17)15-14-6/h1-3,5H,4H2,(H,14,16)(H,15,17)
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n/an/a 26n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210797
PNG
(US9290456, 34 | US9931340, Example 34)
Show SMILES CC(c1ccc(F)cc1)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1/C12H11FN2O2/c1-7(8-2-4-9(13)5-3-8)10-6-11(16)12(17)15-14-10/h2-7H,1H3,(H,14,16)(H,15,17)
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n/an/a 26n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210809
PNG
(US9290456, 47 | US9931340, Example 47)
Show SMILES Cc1ccc(Cc2cc(O)c(=O)[nH]n2)cc1
Show InChI InChI=1S/C12H12N2O2/c1-8-2-4-9(5-3-8)6-10-7-11(15)12(16)14-13-10/h2-5,7H,6H2,1H3,(H,13,15)(H,14,16)
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n/an/a 26n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210822
PNG
(US9290456, 62 | US9931340, Example 62)
Show SMILES Oc1cc(CCc2ccc(cc2C(F)(F)F)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C14H10F6N2O2/c15-13(16,17)8-3-1-7(10(5-8)14(18,19)20)2-4-9-6-11(23)12(24)22-21-9/h1,3,5-6H,2,4H2,(H,21,23)(H,22,24)
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n/an/a 29n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210813
PNG
(US9290456, 51 | US9931340, Example 51)
Show SMILES Oc1cc(CCC2CCOCC2)n[nH]c1=O
Show InChI InChI=1S/C11H16N2O3/c14-10-7-9(12-13-11(10)15)2-1-8-3-5-16-6-4-8/h7-8H,1-6H2,(H,12,14)(H,13,15)
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n/an/a 30n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210776
PNG
(US9290456, 5 | US9931340, Example 5)
Show SMILES Oc1cc(CCc2ccc(nc2)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C12H10F3N3O2/c13-12(14,15)10-4-2-7(6-16-10)1-3-8-5-9(19)11(20)18-17-8/h2,4-6H,1,3H2,(H,17,19)(H,18,20)
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n/an/a 30n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431075
PNG
(CHEMBL2338789 | US10202399, Example 40 | US9290456...)
Show SMILES Oc1cc(CCC2CCCCC2)n[nH]c1=O
Show InChI InChI=1S/C12H18N2O2/c15-11-8-10(13-14-12(11)16)7-6-9-4-2-1-3-5-9/h8-9H,1-7H2,(H,13,15)(H,14,16)
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n/an/a 31n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431077
PNG
(CHEMBL2338787 | US10202399, Example 48 | US9212147...)
Show SMILES CC(c1ccccc1)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1/C12H12N2O2/c1-8(9-5-3-2-4-6-9)10-7-11(15)12(16)14-13-10/h2-8H,1H3,(H,13,15)(H,14,16)
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n/an/a 32n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210780
PNG
(US9290456, 14 | US9931340, Example 14)
Show SMILES Oc1cc(CCC2CC2)n[nH]c1=O
Show InChI InChI=1S/C9H12N2O2/c12-8-5-7(10-11-9(8)13)4-3-6-1-2-6/h5-6H,1-4H2,(H,10,12)(H,11,13)
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n/an/a 41n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210798
PNG
(US9290456, 35 | US9931340, Example 35)
Show SMILES CC(c1cccc(c1)C(F)(F)F)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1/C13H11F3N2O2/c1-7(10-6-11(19)12(20)18-17-10)8-3-2-4-9(5-8)13(14,15)16/h2-7H,1H3,(H,17,19)(H,18,20)
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n/an/a 41n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210790
PNG
(US9290456, 25 | US9931340, Example 25)
Show SMILES COc1ccc(CCc2cc(O)c(=O)[nH]n2)cc1OC
Show InChI InChI=1S/C14H16N2O4/c1-19-12-6-4-9(7-13(12)20-2)3-5-10-8-11(17)14(18)16-15-10/h4,6-8H,3,5H2,1-2H3,(H,15,17)(H,16,18)
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n/an/a 45n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431068
PNG
(CHEMBL2338796 | US10202399, Example 30 | US9212147...)
Show SMILES Oc1cc(CCc2ccccc2C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H11F3N2O2/c14-13(15,16)10-4-2-1-3-8(10)5-6-9-7-11(19)12(20)18-17-9/h1-4,7H,5-6H2,(H,17,19)(H,18,20)
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n/an/a 45n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210782
PNG
(US9290456, 16 | US9931340, Example 16)
Show SMILES COC1CCC(CCc2cc(O)c(=O)[nH]n2)CC1
Show InChI InChI=1S/C13H20N2O3/c1-18-11-6-3-9(4-7-11)2-5-10-8-12(16)13(17)15-14-10/h8-9,11H,2-7H2,1H3,(H,14,16)(H,15,17)
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n/an/a 52n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM50431082
PNG
(CHEMBL2338804 | US10202399, Example 19 | US9212147...)
Show SMILES Oc1cc(CCc2cc(cc(c2)C(F)(F)F)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C14H10F6N2O2/c15-13(16,17)8-3-7(4-9(5-8)14(18,19)20)1-2-10-6-11(23)12(24)22-21-10/h3-6H,1-2H2,(H,21,23)(H,22,24)
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n/an/a 57n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210819
PNG
(US9290456, 58 | US9931340, Example 58)
Show SMILES Oc1cc(n[nH]c1=O)C1(CC1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H11F3N2O2/c15-14(16,17)9-3-1-8(2-4-9)13(5-6-13)11-7-10(20)12(21)19-18-11/h1-4,7H,5-6H2,(H,18,20)(H,19,21)
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n/an/a 61n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210803
PNG
(US9290456, 41 | US9931340, Example 41)
Show SMILES Oc1cc(CC2CCCCC2)n[nH]c1=O
Show InChI InChI=1S/C11H16N2O2/c14-10-7-9(12-13-11(10)15)6-8-4-2-1-3-5-8/h7-8H,1-6H2,(H,12,14)(H,13,15)
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n/an/a 99n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210814
PNG
(US9290456, 52 | US9931340, Example 52)
Show SMILES CN(Cc1ccc(F)cc1)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1S/C12H12FN3O2/c1-16(7-8-2-4-9(13)5-3-8)11-6-10(17)12(18)15-14-11/h2-6H,7H2,1H3,(H,14,17)(H,15,18)
PDB
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Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210799
PNG
(US9290456, 37 | US9931340, Example 37)
Show SMILES CN(CC1CC1)c1cc(O)c(=O)[nH]n1
Show InChI InChI=1S/C9H13N3O2/c1-12(5-6-2-3-6)8-4-7(13)9(14)11-10-8/h4,6H,2-3,5H2,1H3,(H,10,13)(H,11,14)
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n/an/a 220n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210818
PNG
(US9290456, 57 | US9931340, Example 57)
Show SMILES Oc1cc(CC2CC2)n[nH]c1=O
Show InChI InChI=1S/C8H10N2O2/c11-7-4-6(3-5-1-2-5)9-10-8(7)12/h4-5H,1-3H2,(H,9,11)(H,10,12)
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n/an/a 380n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
D-amino-acid oxidase


(Homo sapiens (Human))
BDBM210817
PNG
(US9290456, 55 | US9931340, Example 55)
Show SMILES Oc1cc(Cc2cc(cc(c2)C(F)(F)F)C(F)(F)F)n[nH]c1=O
Show InChI InChI=1S/C13H8F6N2O2/c14-12(15,16)7-1-6(2-8(4-7)13(17,18)19)3-9-5-10(22)11(23)21-20-9/h1-2,4-5H,3H2,(H,20,22)(H,21,23)
PDB
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n/an/a 760n/an/an/an/an/an/a



Takeda Pharmaceutical Company Limited

US Patent


Assay Description
Human DAAO enzyme was supplied by the Takeda Pharmaceutical Company (Osaka) and each batch was tested and used at concentrations giving comparable le...


US Patent US9931340 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%