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Patent code US9932325

Compile Data Set for Download or QSAR

Found 215 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384297
PNG
(US9932325, Example 7)
Show SMILES CNc1nc(Nc2cnn(CC34CC(C3)(C4)C#N)c2C)ncc1C(F)(F)F
Show InChI InChI=1S/C17H18F3N7/c1-10-12(4-24-27(10)9-16-5-15(6-16,7-16)8-21)25-14-23-3-11(17(18,19)20)13(22-2)26-14/h3-4H,5-7,9H2,1-2H3,(H2,22,23,25,26)
PDB

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n/an/a<30n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384304
PNG
(US9932325, Example 9)
Show SMILES CNc1nc(Nc2cnn(C3CC4[C@@H](C3)C4(F)F)c2Cl)ncc1C(F)(F)F
Show InChI InChI=1S/C15H14ClF5N6/c1-22-12-9(15(19,20)21)4-23-13(26-12)25-10-5-24-27(11(10)16)6-2-7-8(3-6)14(7,17)18/h4-8H,2-3H2,1H3,(H2,22,23,25,26)/t6?,7-,8?/m1/s1
PDB

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n/an/a<30n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384314
PNG
(US9932325, Example 17)
Show SMILES CNc1nc(Nc2cnn3CC4(CC4)COc23)ncc1C(F)(F)F
Show InChI InChI=1S/C14H15F3N6O/c1-18-10-8(14(15,16)17)4-19-12(22-10)21-9-5-20-23-6-13(2-3-13)7-24-11(9)23/h4-5H,2-3,6-7H2,1H3,(H2,18,19,21,22)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384321
PNG
(US9932325, Example 21)
Show SMILES Cc1c(Nc2ncc(c(NC3CC3)n2)C(F)(F)F)cnn1C1C[C@@H](C1)C#N
Show InChI InChI=1S/C17H18F3N7/c1-9-14(8-23-27(9)12-4-10(5-12)6-21)25-16-22-7-13(17(18,19)20)15(26-16)24-11-2-3-11/h7-8,10-12H,2-5H2,1H3,(H2,22,24,25,26)/t10-,12?
PDB

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n/an/a<30n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384323
PNG
(US9932325, Example 22 | US9932325, Example 23 | US...)
Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H22F3N7O/c1-5-21-13-11(17(18,19)20)8-22-15(24-13)23-12-9-27(25-10(12)2)16(3)6-7-26(4)14(16)28/h8-9H,5-7H2,1-4H3,(H2,21,22,23,24)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384343
PNG
(US9932325, Example 32)
Show SMILES CCNc1nc(Nc2cnn(C3CCC3)c2C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C15H16F3N7/c1-2-20-13-10(15(16,17)18)7-21-14(24-13)23-11-8-22-25(12(11)6-19)9-4-3-5-9/h7-9H,2-5H2,1H3,(H2,20,21,23,24)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384359
PNG
(US9932325, Example 42)
Show SMILES CNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1Br
Show InChI InChI=1S/C13H16BrN7/c1-8-10(6-21(20-8)13(2,3)7-15)18-12-17-5-9(14)11(16-4)19-12/h5-6H,1-4H3,(H2,16,17,18,19)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384363
PNG
(BDBM384372 | US9932325, Example 46)
Show SMILES Cc1nn(cc1Nc1ncc(c(NCC(F)F)n1)C(F)(F)F)C(C)(C)C#N
Show InChI InChI=1S/C15H16F5N7/c1-8-10(6-27(26-8)14(2,3)7-21)24-13-23-4-9(15(18,19)20)12(25-13)22-5-11(16)17/h4,6,11H,5H2,1-3H3,(H2,22,23,24,25)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384368
PNG
(US9932325, Example 54A | US9932325, Example 54B)
Show SMILES CCNc1nc(Nc2cnn3CC(Cc23)n2nccn2)ncc1C(F)(F)F
Show InChI InChI=1S/C15H16F3N9/c1-2-19-13-10(15(16,17)18)6-20-14(25-13)24-11-7-23-26-8-9(5-12(11)26)27-21-3-4-22-27/h3-4,6-7,9H,2,5,8H2,1H3,(H2,19,20,24,25)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384368
PNG
(US9932325, Example 54A | US9932325, Example 54B)
Show SMILES CCNc1nc(Nc2cnn3CC(Cc23)n2nccn2)ncc1C(F)(F)F
Show InChI InChI=1S/C15H16F3N9/c1-2-19-13-10(15(16,17)18)6-20-14(25-13)24-11-7-23-26-8-9(5-12(11)26)27-21-3-4-22-27/h3-4,6-7,9H,2,5,8H2,1H3,(H2,19,20,24,25)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384347
PNG
(BDBM384370 | US9932325, Example 34)
Show SMILES CCNc1nc(Nc2cc(nn2C)C(C)(C)n2nccn2)ncc1C(F)(F)F
Show InChI InChI=1S/C16H20F3N9/c1-5-20-13-10(16(17,18)19)9-21-14(25-13)24-12-8-11(26-27(12)4)15(2,3)28-22-6-7-23-28/h6-9H,5H2,1-4H3,(H2,20,21,24,25)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384371
PNG
(US9932325, Example 58)
Show SMILES CCNc1nc(Nc2cnn(C3CCC3)c2C#N)ncc1Br
Show InChI InChI=1S/C14H16BrN7/c1-2-17-13-10(15)7-18-14(21-13)20-11-8-19-22(12(11)6-16)9-4-3-5-9/h7-9H,2-5H2,1H3,(H2,17,18,20,21)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384363
PNG
(BDBM384372 | US9932325, Example 46)
Show SMILES Cc1nn(cc1Nc1ncc(c(NCC(F)F)n1)C(F)(F)F)C(C)(C)C#N
Show InChI InChI=1S/C15H16F5N7/c1-8-10(6-27(26-8)14(2,3)7-21)24-13-23-4-9(15(18,19)20)12(25-13)22-5-11(16)17/h4,6,11H,5H2,1-3H3,(H2,22,23,24,25)
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384373
PNG
(US9932325, Example 60)
Show SMILES Cc1nn(cc1Nc1ncc(Cl)c(OC2CC2)n1)C(C)(C)C#N
Show InChI InChI=1S/C15H17ClN6O/c1-9-12(7-22(21-9)15(2,3)8-17)19-14-18-6-11(16)13(20-14)23-10-4-5-10/h6-7,10H,4-5H2,1-3H3,(H,18,19,20)
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50448118
PNG
(CHEMBL3122113 | US9932325, Example 80)
Show SMILES CNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C14H16F3N7/c1-8-10(6-24(23-8)13(2,3)7-18)21-12-20-5-9(14(15,16)17)11(19-4)22-12/h5-6H,1-4H3,(H2,19,20,21,22)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384377
PNG
(US9932325, Example 64A | US9932325, Example 64B)
Show SMILES COc1nc(Nc2cn(nc2C)C2(C)CCNC2=O)ncc1Br
Show InChI InChI=1S/C14H17BrN6O2/c1-8-10(18-13-17-6-9(15)11(19-13)23-3)7-21(20-8)14(2)4-5-16-12(14)22/h6-7H,4-5H2,1-3H3,(H,16,22)(H,17,18,19)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384391
PNG
(US9932325, Example 77)
Show SMILES CNc1nc(Nc2cc(nn2C2CC2)C(C)(C)n2nccn2)ncc1C(F)(F)F
Show InChI InChI=1S/C17H20F3N9/c1-16(2,29-23-6-7-24-29)12-8-13(28(27-12)10-4-5-10)25-15-22-9-11(17(18,19)20)14(21-3)26-15/h6-10H,4-5H2,1-3H3,(H2,21,22,25,26)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50448118
PNG
(CHEMBL3122113 | US9932325, Example 80)
Show SMILES CNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C14H16F3N7/c1-8-10(6-24(23-8)13(2,3)7-18)21-12-20-5-9(14(15,16)17)11(19-4)22-12/h5-6H,1-4H3,(H2,19,20,21,22)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384395
PNG
(US9932325, Example 81)
Show SMILES Cn1nc(cc1Nc1ncc(Br)c(OC2CC2)n1)C(C)(C)n1nccn1
Show InChI InChI=1S/C16H19BrN8O/c1-16(2,25-19-6-7-20-25)12-8-13(24(3)23-12)21-15-18-9-11(17)14(22-15)26-10-4-5-10/h6-10H,4-5H2,1-3H3,(H,18,21,22)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384404
PNG
(US9932325, Example 102 | US9932325, Example 90)
Show SMILES COc1nc(Nc2cn(nc2C)C2(C)CCOC2=O)ncc1Br
Show InChI InChI=1S/C14H16BrN5O3/c1-8-10(17-13-16-6-9(15)11(18-13)22-3)7-20(19-8)14(2)4-5-23-12(14)21/h6-7H,4-5H2,1-3H3,(H,16,17,18)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384405
PNG
(US9932325, Example 104 | US9932325, Example 108 | ...)
Show SMILES CCNc1nc(Nc2cn(nc2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C18H21F3N6O2/c1-3-22-14-11(18(19,20)21)8-23-16(25-14)24-12-9-27(26-13(12)10-4-5-10)17(2)6-7-29-15(17)28/h8-10H,3-7H2,1-2H3,(H2,22,23,24,25)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384406
PNG
(US9932325, Example 116 | US9932325, Example 92)
Show SMILES CCNc1nc(Nc2cnn(C3CCCN(CC(F)F)C3)c2C)ncc1C(F)(F)F
Show InChI InChI=1S/C18H24F5N7/c1-3-24-16-13(18(21,22)23)7-25-17(28-16)27-14-8-26-30(11(14)2)12-5-4-6-29(9-12)10-15(19)20/h7-8,12,15H,3-6,9-10H2,1-2H3,(H2,24,25,27,28)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384408
PNG
(US9932325, Example 94)
Show SMILES CCNc1nc(Nc2cn(Cc3ccon3)nc2C2CC2)ncc1C(F)(F)F
Show InChI InChI=1S/C17H18F3N7O/c1-2-21-15-12(17(18,19)20)7-22-16(24-15)23-13-9-27(8-11-5-6-28-26-11)25-14(13)10-3-4-10/h5-7,9-10H,2-4,8H2,1H3,(H2,21,22,23,24)
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384427
PNG
(US9932325, Example 113 | US9932325, Example 122)
Show SMILES CNc1nc(Nc2cn(nc2C2CC2)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H19F3N6O2/c1-16(5-6-28-14(16)27)26-8-11(12(25-26)9-3-4-9)23-15-22-7-10(17(18,19)20)13(21-2)24-15/h7-9H,3-6H2,1-2H3,(H2,21,22,23,24)
PDB

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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384448
PNG
(US9932325, Example 134)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C(C)(C)O)ncc1C(F)(F)F
Show InChI InChI=1S/C16H21F3N6O/c1-4-20-13-10(16(17,18)19)8-21-14(23-13)22-12-7-11(15(2,3)26)24-25(12)9-5-6-9/h7-9,26H,4-6H2,1-3H3,(H2,20,21,22,23)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384459
PNG
(US9932325, Example 145)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C2(C)COC2)ncc1C(F)(F)F
Show InChI InChI=1S/C17H21F3N6O/c1-3-21-14-11(17(18,19)20)7-22-15(24-14)23-13-6-12(16(2)8-27-9-16)25-26(13)10-4-5-10/h6-7,10H,3-5,8-9H2,1-2H3,(H2,21,22,23,24)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384464
PNG
(US9932325, Example 150 | US9932325, Example 151)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)C2(C)CCOC2=O)ncc1Br
Show InChI InChI=1S/C17H21BrN6O2/c1-3-19-14-11(18)9-20-16(22-14)21-13-8-12(23-24(13)10-4-5-10)17(2)6-7-26-15(17)25/h8-10H,3-7H2,1-2H3,(H2,19,20,21,22)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384468
PNG
(US9932325, Example 154)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)N2CCCS2(=O)=O)ncc1C(F)(F)F
Show InChI InChI=1S/C16H20F3N7O2S/c1-2-20-14-11(16(17,18)19)9-21-15(23-14)22-12-8-13(24-26(12)10-4-5-10)25-6-3-7-29(25,27)28/h8-10H,2-7H2,1H3,(H2,20,21,22,23)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384472
PNG
(US9932325, Example 158)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)N2CCCC2=O)ncc1Br
Show InChI InChI=1S/C16H20BrN7O/c1-2-18-15-11(17)9-19-16(21-15)20-12-8-13(22-24(12)10-5-6-10)23-7-3-4-14(23)25/h8-10H,2-7H2,1H3,(H2,18,19,20,21)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384477
PNG
(US9932325, Example 163)
Show SMILES CNc1nc(Nc2cc(nn2C2CC2)[C@@]23C[C@@H]2COC3=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H17F3N6O2/c1-21-13-10(17(18,19)20)6-22-15(24-13)23-12-4-11(25-26(12)9-2-3-9)16-5-8(16)7-28-14(16)27/h4,6,8-9H,2-3,5,7H2,1H3,(H2,21,22,23,24)/t8-,16-/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384483
PNG
(US9932325, Example 169)
Show SMILES CCNc1nc(Nc2cc(nn2C2CC2)[C@H]2C[C@H]2C(=O)OCC)ncc1C(F)(F)F
Show InChI InChI=1S/C19H23F3N6O2/c1-3-23-16-13(19(20,21)22)9-24-18(26-16)25-15-8-14(27-28(15)10-5-6-10)11-7-12(11)17(29)30-4-2/h8-12H,3-7H2,1-2H3,(H2,23,24,25,26)/t11-,12+/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384487
PNG
(US9932325, Example 173 | US9932325, Example 174)
Show SMILES CCNc1nc(Nc2cc(nn2C)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C16H19F3N6O2/c1-4-20-12-9(16(17,18)19)8-21-14(23-12)22-11-7-10(24-25(11)3)15(2)5-6-27-13(15)26/h7-8H,4-6H2,1-3H3,(H2,20,21,22,23)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384489
PNG
(US9932325, Example 175 | US9932325, Example 176)
Show SMILES CNc1nc(Nc2cc(nn2C)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C15H17F3N6O2/c1-14(4-5-26-12(14)25)9-6-10(24(3)23-9)21-13-20-7-8(15(16,17)18)11(19-2)22-13/h6-7H,4-5H2,1-3H3,(H2,19,20,21,22)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384489
PNG
(US9932325, Example 175 | US9932325, Example 176)
Show SMILES CNc1nc(Nc2cc(nn2C)C2(C)CCOC2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C15H17F3N6O2/c1-14(4-5-26-12(14)25)9-6-10(24(3)23-9)21-13-20-7-8(15(16,17)18)11(19-2)22-13/h6-7H,4-5H2,1-3H3,(H2,19,20,21,22)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384491
PNG
(US9932325, Example 177 | US9932325, Example 178)
Show SMILES CNc1nc(Nc2cc(nn2C2CC2)C2(C)CCn3ccnc23)ncc1C(F)(F)F
Show InChI InChI=1S/C19H21F3N8/c1-18(5-7-29-8-6-24-16(18)29)13-9-14(30(28-13)11-3-4-11)26-17-25-10-12(19(20,21)22)15(23-2)27-17/h6,8-11H,3-5,7H2,1-2H3,(H2,23,25,26,27)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384493
PNG
(US9932325, Example 179)
Show SMILES CCNc1nc(Nc2ccnn2[C@@H]2C[C@H](O)C2)ncc1C(F)(F)F
Show InChI InChI=1S/C14H17F3N6O/c1-2-18-12-10(14(15,16)17)7-19-13(22-12)21-11-3-4-20-23(11)8-5-9(24)6-8/h3-4,7-9,24H,2,5-6H2,1H3,(H2,18,19,21,22)/t8-,9+
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384495
PNG
(US9932325, Example 181)
Show SMILES CCNc1nc(Nc2ccnn2[C@H]2C[C@@H](C2)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C15H16F3N7/c1-2-20-13-11(15(16,17)18)8-21-14(24-13)23-12-3-4-22-25(12)10-5-9(6-10)7-19/h3-4,8-10H,2,5-6H2,1H3,(H2,20,21,23,24)/t9-,10-
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384500
PNG
(US9932325, Example 186 | US9932325, Example 187)
Show SMILES CCNc1nc(Nc2cc(nn2C)C2(C)CCCO2)ncc1C(F)(F)F
Show InChI InChI=1S/C16H21F3N6O/c1-4-20-13-10(16(17,18)19)9-21-14(23-13)22-12-8-11(24-25(12)3)15(2)6-5-7-26-15/h8-9H,4-7H2,1-3H3,(H2,20,21,22,23)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384511
PNG
(US9932325, Example 197)
Show SMILES CCNc1nc(Nc2cn(nc2[C@H]2C[C@H](C2)n2nccn2)C2CC2)ncc1C(F)(F)F
Show InChI InChI=1S/C19H22F3N9/c1-2-23-17-14(19(20,21)22)9-24-18(28-17)27-15-10-30(12-3-4-12)29-16(15)11-7-13(8-11)31-25-5-6-26-31/h5-6,9-13H,2-4,7-8H2,1H3,(H2,23,24,27,28)/t11-,13+
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384512
PNG
(US9932325, Example 198)
Show SMILES CNc1nc(Nc2cn(nc2[C@H]2C[C@@H](C2)n2nccn2)C2CC2)ncc1C(F)(F)F
Show InChI InChI=1S/C18H20F3N9/c1-22-16-13(18(19,20)21)8-23-17(27-16)26-14-9-29(11-2-3-11)28-15(14)10-6-12(7-10)30-24-4-5-25-30/h4-5,8-12H,2-3,6-7H2,1H3,(H2,22,23,26,27)/t10-,12-
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384523
PNG
(US9932325, Example 209)
Show SMILES CNc1nc(Nc2cn(nc2C2CC2)C2C[C@H]2C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C16H16F3N7/c1-21-14-10(16(17,18)19)6-22-15(24-14)23-11-7-26(12-4-9(12)5-20)25-13(11)8-2-3-8/h6-9,12H,2-4H2,1H3,(H2,21,22,23,24)/t9-,12?/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384527
PNG
(US9932325, Example 213)
Show SMILES COc1nc(Nc2cn(nc2C2CC2)C2C[C@H]2C#N)ncc1Br
Show InChI InChI=1S/C15H15BrN6O/c1-23-14-10(16)6-18-15(20-14)19-11-7-22(12-4-9(12)5-17)21-13(11)8-2-3-8/h6-9,12H,2-4H2,1H3,(H,18,19,20)/t9-,12?/m0/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384310
PNG
(US9932325, Example 14 | US9932325, Example 218)
Show SMILES CNc1nc(Nc2cn(nc2C)C(C)(C)c2ncn(C)n2)ncc1C(F)(F)F
Show InChI InChI=1S/C16H20F3N9/c1-9-11(7-28(25-9)15(2,3)13-22-8-27(5)26-13)23-14-21-6-10(16(17,18)19)12(20-4)24-14/h6-8H,1-5H3,(H2,20,21,23,24)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384323
PNG
(US9932325, Example 22 | US9932325, Example 23 | US...)
Show SMILES CCNc1nc(Nc2cn(nc2C)C2(C)CCN(C)C2=O)ncc1C(F)(F)F
Show InChI InChI=1S/C17H22F3N7O/c1-5-21-13-11(17(18,19)20)8-22-15(24-13)23-12-9-27(25-10(12)2)16(3)6-7-26(4)14(16)28/h8-9H,5-7H2,1-4H3,(H2,21,22,23,24)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384356
PNG
(US9932325, Example 39A)
Show SMILES Cc1nn(cc1Nc1ncc(c(N[C@H]2C[C@H]2F)n1)C(F)(F)F)C(C)(C)C#N
Show InChI InChI=1S/C16H17F4N7/c1-8-12(6-27(26-8)15(2,3)7-21)24-14-22-5-9(16(18,19)20)13(25-14)23-11-4-10(11)17/h5-6,10-11H,4H2,1-3H3,(H2,22,23,24,25)/t10-,11+/m1/s1
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384366
PNG
(US9932325, Example 52A | US9932325, Example 52B)
Show SMILES CCNc1nc(Nc2cnn3CC(Cc23)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C14H14F3N7/c1-2-19-12-9(14(15,16)17)5-20-13(23-12)22-10-6-21-24-7-8(4-18)3-11(10)24/h5-6,8H,2-3,7H2,1H3,(H2,19,20,22,23)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384366
PNG
(US9932325, Example 52A | US9932325, Example 52B)
Show SMILES CCNc1nc(Nc2cnn3CC(Cc23)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C14H14F3N7/c1-2-19-12-9(14(15,16)17)5-20-13(23-12)22-10-6-21-24-7-8(4-18)3-11(10)24/h5-6,8H,2-3,7H2,1H3,(H2,19,20,22,23)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM50448118
PNG
(CHEMBL3122113 | US9932325, Example 80)
Show SMILES CNc1nc(Nc2cn(nc2C)C(C)(C)C#N)ncc1C(F)(F)F
Show InChI InChI=1S/C14H16F3N7/c1-8-10(6-24(23-8)13(2,3)7-18)21-12-20-5-9(14(15,16)17)11(19-4)22-12/h5-6H,1-4H3,(H2,19,20,21,22)
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Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384387
PNG
(US9932325, Example 73)
Show SMILES Cc1nn(cc1Nc1ncc(Br)c(NCC(F)F)n1)C(C)(C)C#N
Show InChI InChI=1S/C14H16BrF2N7/c1-8-10(6-24(23-8)14(2,3)7-18)21-13-20-4-9(15)12(22-13)19-5-11(16)17/h4,6,11H,5H2,1-3H3,(H2,19,20,21,22)
PDB

GoogleScholar
UniChem
US Patent
n/an/a<30n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
Leucine-rich repeat serine/threonine-protein kinase 2 G2019S


(Homo sapiens (Human))
BDBM384398
PNG
(US9932325, Example 84)
Show SMILES Cc1nn(cc1Nc1ncc(c(NC2(C)CC2)n1)C(F)(F)F)C(C)(C)C#N
Show InChI InChI=1S/C17H20F3N7/c1-10-12(8-27(26-10)15(2,3)9-21)23-14-22-7-11(17(18,19)20)13(24-14)25-16(4)5-6-16/h7-8H,5-6H2,1-4H3,(H2,22,23,24,25)
PDB

GoogleScholar
UniChem
US Patent
n/an/a<30n/an/an/an/an/an/a



Denali Therapeutics Inc.

US Patent


Assay Description
Materials: LRRK2 G2019S enzyme Substrate (LRRKtide) ATP TR-FRET dilution buffer pLRRKtide antibody 384-well...


US Patent US9932325 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%