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Patent code US9932341

Compile Data Set for Download or QSAR
Found 125 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261216
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)(C)C(N)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H29ClN8O2/c1-6-35-20-15(13(3)33-22-18(12(2)31-33)21(27)29-11-30-22)7-17(25)16(8-26)19(20)14-9-32(10-14)24(4,5)23(28)34/h7,11,13-14H,6,9-10H2,1-5H3,(H2,28,34)(H2,27,29,30)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261258
PNG
(2-(1-Acetylazetidin-3-yl)-4-[1-(4-amino-3-methyl-1...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H22ClN7O2/c1-10-17-20(24)25-9-26-21(17)29(27-10)11(2)14-5-16(22)15(6-23)18(19(14)31-4)13-7-28(8-13)12(3)30/h5,9,11,13H,7-8H2,1-4H3,(H2,24,25,26)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261269
PNG
(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)NC(C)(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H29ClN8O2/c1-12-18-21(27)28-11-29-22(18)33(31-12)13(2)15-7-17(25)16(8-26)19(20(15)35-6)14-9-32(10-14)23(34)30-24(3,4)5/h7,11,13-14H,9-10H2,1-6H3,(H,30,34)(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261273
PNG
(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H25ClN8O2/c1-11-17-20(25)26-10-27-21(17)31(28-11)12(2)14-6-16(23)15(7-24)18(19(14)33-5)13-8-30(9-13)22(32)29(3)4/h6,10,12-13H,8-9H2,1-5H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM334153
PNG
(4-[1-(4-Amino-5-methyl-7H-pyrrolo[2,3-d]pyrimidin-...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)C)C(C)n1cc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H29ClN6O/c1-6-32-22-17(15(5)31-9-14(4)20-23(27)28-12-29-24(20)31)7-19(25)18(8-26)21(22)16-10-30(11-16)13(2)3/h7,9,12-13,15-16H,6,10-11H2,1-5H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261299
PNG
(US10092570, Example 321 | US9707233, 328 | US97309...)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H33N7O2/c1-7-34-22-18(16(4)32-24-20(15(3)30-32)23(27)28-13-29-24)8-14(2)19(9-26)21(22)17-10-31(11-17)12-25(5,6)33/h8,13,16-17,33H,7,10-12H2,1-6H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261320
PNG
(US10092570, Example 323 | US9707233, 323 (3rd peak...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261320
PNG
(US10092570, Example 323 | US9707233, 323 (3rd peak...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255790
PNG
(1-{1-[5-Chloro-3-(1-isopropylazetidin-3-yl)-2-meth...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H29ClN6O/c1-11(2)28-8-15(9-28)18-12(3)17(23)7-16(20(18)30-6)14(5)29-22-19(13(4)27-29)21(24)25-10-26-22/h7,10-11,14-15H,8-9H2,1-6H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255795
PNG
(1-{1-[5-Chloro-3-(1-ethylazetidin-3-yl)-2-methoxy-...)
Show SMILES CCN1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1/C21H27ClN6O/c1-6-27-8-14(9-27)17-11(2)16(22)7-15(19(17)29-5)13(4)28-21-18(12(3)26-28)20(23)24-10-25-21/h7,10,13-14H,6,8-9H2,1-5H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255803
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)10-18(26)13(2)20(22)16-8-9-19(28-11-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255808
PNG
(4-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H28ClN7O3/c1-13-18(26)11-17(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-6-7-28-19(10-16)25(35)32(4)8-9-34/h6-7,10-12,15,34H,8-9H2,1-5H3,(H2,27,29,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255834
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1cncc(c1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H22ClN7O3S/c1-5-34-21-16(13(3)31-23-19(12(2)30-31)22(26)28-11-29-23)7-18(24)17(8-25)20(21)14-6-15(10-27-9-14)35(4,32)33/h6-7,9-11,13H,5H2,1-4H3,(H2,26,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255856
PNG
(5-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H26ClN7O2/c1-12-18(25)8-17(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-16(10-27-9-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261073
PNG
((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H31ClN6O2/c1-6-32-21-17(15(5)30-23-20(14(4)28-30)22(25)26-11-27-23)7-18(24)13(3)19(21)16-9-29(10-16)8-12(2)31/h7,11-12,15-16,31H,6,8-10H2,1-5H3,(H2,25,26,27)/t12-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261138
PNG
(US10092570, Example 161 | US9707233, 161 | US97309...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C1(CC#N)CCC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H30ClN7O/c1-14-19(26)10-18(16(3)33-24-21(15(2)31-33)23(28)29-13-30-24)22(34-4)20(14)17-11-32(12-17)25(8-9-27)6-5-7-25/h10,13,16-17H,5-8,11-12H2,1-4H3,(H2,28,29,30)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261224
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(=O)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H28ClN7O3/c1-6-35-20-15(13(3)32-22-18(12(2)30-32)21(27)28-11-29-22)7-17(25)16(8-26)19(20)14-9-31(10-14)23(33)24(4,5)34/h7,11,13-14,34H,6,9-10H2,1-5H3,(H2,27,28,29)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261239
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H22ClN7O/c1-10-16-19(23)24-9-25-20(16)28(26-10)11(2)13-5-15(21)14(6-22)17(18(13)29-4)12-7-27(3)8-12/h5,9,11-12H,7-8H2,1-4H3,(H2,23,24,25)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261245
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClN7O2/c1-11-17-20(24)25-10-26-21(17)29(27-11)12(2)14-6-16(22)15(7-23)18(19(14)31-3)13-8-28(9-13)4-5-30/h6,10,12-13,30H,4-5,8-9H2,1-3H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261266
PNG
(Methyl 3-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d...)
Show SMILES COC(=O)N1CC(C1)c1c(OC)c(cc(Cl)c1C#N)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H22ClN7O3/c1-10-16-19(24)25-9-26-20(16)29(27-10)11(2)13-5-15(22)14(6-23)17(18(13)31-3)12-7-28(8-12)21(30)32-4/h5,9,11-12H,7-8H2,1-4H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289341
PNG
(US10092570, Example 324 | US9730939, Example 324 |...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CNC(=O)CO1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H23ClN6O3/c1-9-13(21)5-12(18(29-4)16(9)14-6-23-15(28)7-30-14)11(3)27-20-17(10(2)26-27)19(22)24-8-25-20/h5,8,11,14H,6-7H2,1-4H3,(H,23,28)(H2,22,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261178
PNG
(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H26ClN7O2/c1-12-17(25)10-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-27-18(9-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289019
PNG
(US10092570, Example 20 | US9730939, Example 20 | U...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(CCO)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClN7O2/c1-11-16(22)7-15(19(31-4)17(11)14-8-26-28(9-14)5-6-30)13(3)29-21-18(12(2)27-29)20(23)24-10-25-21/h7-10,13,30H,5-6H2,1-4H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261081
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H27ClN6O2/c1-11-16(22)7-15(19(30-4)17(11)14-8-27(9-14)5-6-29)13(3)28-21-18(12(2)26-28)20(23)24-10-25-21/h7,10,13-14,29H,5-6,8-9H2,1-4H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261085
PNG
(1-(1-{5-Chloro-2-methoxy-4-methyl-3-[1-(2,2,2-trif...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(F)(F)F)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClF3N6O/c1-10-15(22)5-14(12(3)31-20-17(11(2)29-31)19(26)27-9-28-20)18(32-4)16(10)13-6-30(7-13)8-21(23,24)25/h5,9,12-13H,6-8H2,1-4H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261087
PNG
((2R)-2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES CNC(=O)[C@@H](C)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1/C23H30ClN7O2/c1-11-17(24)7-16(13(3)31-22-19(12(2)29-31)21(25)27-10-28-22)20(33-6)18(11)15-8-30(9-15)14(4)23(32)26-5/h7,10,13-15H,8-9H2,1-6H3,(H,26,32)(H2,25,27,28)/t13?,14-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261090
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(CO)C(F)(F)F)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClF3N6O2/c1-10-15(23)5-14(12(3)32-21-18(11(2)30-32)20(27)28-9-29-21)19(34-4)17(10)13-6-31(7-13)16(8-33)22(24,25)26/h5,9,12-13,16,33H,6-8H2,1-4H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289138
PNG
(US10092570, Example 139 | US9730939, Example 139 |...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H28ClFN6O/c1-6-31-20-15(7-16(23)19(24)18(20)14-8-29(9-14)11(2)3)13(5)30-22-17(12(4)28-30)21(25)26-10-27-22/h7,10-11,13-14H,6,8-9H2,1-5H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261141
PNG
(1-(4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CCN(CC(C)(C)O)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H35ClN6O2/c1-14-19(26)11-18(16(3)32-24-21(15(2)30-32)23(27)28-13-29-24)22(34-6)20(14)17-7-9-31(10-8-17)12-25(4,5)33/h11,13,16-17,33H,7-10,12H2,1-6H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261190
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClN7O/c1-5-30-19-14(6-16(22)15(7-23)18(19)13-8-28(4)9-13)12(3)29-21-17(11(2)27-29)20(24)25-10-26-21/h6,10,12-13H,5,8-9H2,1-4H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261213
PNG
(US9707233, 236 | US9932341, Example 236 | tert-But...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)(C)C(=O)OC(C)(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C28H36ClN7O3/c1-9-38-23-18(16(3)36-25-21(15(2)34-36)24(31)32-14-33-25)10-20(29)19(11-30)22(23)17-12-35(13-17)28(7,8)26(37)39-27(4,5)6/h10,14,16-17H,9,12-13H2,1-8H3,(H2,31,32,33)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM334118
PNG
(Diastereoisomers of 4-[1-(4-amino-3-methyl-1H-pyra...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClN7O2/c1-11(9-31)29-7-14(8-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM272572
PNG
(US10065963, Compound 32b | US9932341, Example 346)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM334198
PNG
(Diastereomers of 4-{3-[1-(4-amino-3-methyl-1H-pyra...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1COC(=O)N1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-30-19(28)25-12)9(3)27-18-13(8(2)26-27)17(22)23-7-24-18/h5,7,9,12H,4,6H2,1-3H3,(H,25,28)(H2,22,23,24)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255793
PNG
(1-(1-{5-Chloro-3-[1-(cyclopropylmethyl)azetidin-3-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC2CC2)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H29ClN6O/c1-12-18(24)7-17(14(3)30-23-20(13(2)28-30)22(25)26-11-27-23)21(31-4)19(12)16-9-29(10-16)8-15-5-6-15/h7,11,14-16H,5-6,8-10H2,1-4H3,(H2,25,26,27)
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255798
PNG
(1-(1-{5-Chloro-2-methoxy-3-[1-(2-methoxyethyl)azet...)
Show SMILES COCCN1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1/C22H29ClN6O2/c1-12-17(23)8-16(20(31-5)18(12)15-9-28(10-15)6-7-30-4)14(3)29-22-19(13(2)27-29)21(24)25-11-26-22/h8,11,14-15H,6-7,9-10H2,1-5H3,(H2,24,25,26)
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255802
PNG
(1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H26ClFN6O/c1-10(2)28-7-13(8-28)17-18(23)15(22)6-14(19(17)30-5)12(4)29-21-16(11(3)27-29)20(24)25-9-26-21/h6,9-10,12-13H,7-8H2,1-5H3,(H2,24,25,26)
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261082
PNG
((3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC#N)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClN7O/c1-11-16(22)7-15(19(30-4)17(11)14-8-28(9-14)6-5-23)13(3)29-21-18(12(2)27-29)20(24)25-10-26-21/h7,10,13-14H,6,8-9H2,1-4H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261095
PNG
((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@H](C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H27ClN6O3/c1-10-16(23)6-15(12(3)29-21-18(11(2)27-29)20(24)25-9-26-21)19(32-5)17(10)14-7-28(8-14)22(31)13(4)30/h6,9,12-14,30H,7-8H2,1-5H3,(H2,24,25,26)/t12?,13-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM384608
PNG
(2-(5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(OCCO)nc1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H25ClN6O3/c1-12-17(24)9-16(14(3)30-23-20(13(2)29-30)22(25)27-11-28-23)21(32-4)19(12)15-5-6-18(26-10-15)33-8-7-31/h5-6,9-11,14,31H,7-8H2,1-4H3,(H2,25,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM384609
PNG
(5-(3-(1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CC(c1cc(Cl)c(C)c(-c2ccc(nc2)C(=O)N(C)C)c1OCC(F)F)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C25H26ClF2N7O2/c1-12-17(26)8-16(14(3)35-24-21(13(2)33-35)23(29)31-11-32-24)22(37-10-19(27)28)20(12)15-6-7-18(30-9-15)25(36)34(4)5/h6-9,11,14,19H,10H2,1-5H3,(H2,29,31,32)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255803
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H28ClN7O2/c1-7-35-22-17(15(4)33-24-21(14(3)31-33)23(27)29-12-30-24)10-18(26)13(2)20(22)16-8-9-19(28-11-16)25(34)32(5)6/h8-12,15H,7H2,1-6H3,(H2,27,29,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261185
PNG
(6-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1ccc(cn1)C(=O)N(C)C)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1/C25H30ClN7O2/c1-7-35-22-17(15(4)32-24-21(14(3)27)23(28)30-12-31-24)10-18(26)13(2)20(22)19-9-8-16(11-29-19)25(34)33(5)6/h8-12,15,27H,7H2,1-6H3,(H3,28,30,31,32)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261189
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H22ClN7O/c1-4-29-18-13(5-15(21)14(6-22)17(18)12-7-24-8-12)11(3)28-20-16(10(2)27-28)19(23)25-9-26-20/h5,9,11-12,24H,4,7-8H2,1-3H3,(H2,23,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261320
PNG
(US10092570, Example 323 | US9707233, 323 (3rd peak...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255791
PNG
(1-{1-[3-(1-Acetylazetidin-3-yl)-5-chloro-2-methoxy...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(C)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H25ClN6O2/c1-10-16(22)6-15(19(30-5)17(10)14-7-27(8-14)13(4)29)12(3)28-21-18(11(2)26-28)20(23)24-9-25-21/h6,9,12,14H,7-8H2,1-5H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255792
PNG
(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-propionylaz...)
Show SMILES CCC(=O)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1/C22H27ClN6O2/c1-6-17(30)28-8-14(9-28)18-11(2)16(23)7-15(20(18)31-5)13(4)29-22-19(12(3)27-29)21(24)25-10-26-22/h7,10,13-14H,6,8-9H2,1-5H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255794
PNG
(1-{1-[5-chloro-2-methoxy-4-methyl-3-(1-methylazeti...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H25ClN6O/c1-10-15(21)6-14(18(28-5)16(10)13-7-26(4)8-13)12(3)27-20-17(11(2)25-27)19(22)23-9-24-20/h6,9,12-13H,7-8H2,1-5H3,(H2,22,23,24)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255813
PNG
(5-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)NCCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H26ClN7O3/c1-12-17(25)9-16(14(3)32-23-20(13(2)31-32)22(26)29-11-30-23)21(35-4)19(12)15-5-6-18(28-10-15)24(34)27-7-8-33/h5-6,9-11,14,33H,7-8H2,1-4H3,(H,27,34)(H2,26,29,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261071
PNG
(1-{1-[5-Chloro-2-ethoxy-3-(1-isopropylazetidin-3-y...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H31ClN6O/c1-7-31-21-17(8-18(24)13(4)19(21)16-9-29(10-16)12(2)3)15(6)30-23-20(14(5)28-30)22(25)26-11-27-23/h8,11-12,15-16H,7,9-10H2,1-6H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261092
PNG
((2R)-3-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C[C@@H](O)C(F)(F)F)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClF3N6O2/c1-10-15(23)5-14(12(3)32-21-18(11(2)30-32)20(27)28-9-29-21)19(34-4)17(10)13-6-31(7-13)8-16(33)22(24,25)26/h5,9,12-13,16,33H,6-8H2,1-4H3,(H2,27,28,29)/t12?,16-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261140
PNG
(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CCN(C)CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H29ClN6O/c1-12-17(23)10-16(20(30-5)18(12)15-6-8-28(4)9-7-15)14(3)29-22-19(13(2)27-29)21(24)25-11-26-22/h10-11,14-15H,6-9H2,1-5H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261143
PNG
(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CC(O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H24ClN5O2/c1-9-15(21)7-14(18(28-4)16(9)12-5-13(27)6-12)11(3)26-20-17(10(2)25-26)19(22)23-8-24-20/h7-8,11-13,27H,5-6H2,1-4H3,(H2,22,23,24)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261146
PNG
(1-(1-(3-(2-aminopyrimidin-5-yl)-5- chloro-2-methox...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnc(N)nc1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H21ClN8O/c1-9-14(21)5-13(17(30-4)15(9)12-6-24-20(23)25-7-12)11(3)29-19-16(10(2)28-29)18(22)26-8-27-19/h5-8,11H,1-4H3,(H2,22,26,27)(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261160
PNG
(1-[1-(5-Chloro-3-{1-[2-(dimethylamino)ethyl]-1H-py...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(CCN(C)C)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H29ClN8O/c1-13-18(24)9-17(15(3)32-23-20(14(2)29-32)22(25)26-12-27-23)21(33-6)19(13)16-10-28-31(11-16)8-7-30(4)5/h9-12,15H,7-8H2,1-6H3,(H2,25,26,27)
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261214
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)(C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H30ClN7O2/c1-6-34-21-16(14(3)32-23-19(13(2)30-32)22(27)28-12-29-23)7-18(25)17(8-26)20(21)15-9-31(10-15)24(4,5)11-33/h7,12,14-15,33H,6,9-11H2,1-5H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261292
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1N1CCCC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClN7O/c1-4-30-19-14(9-16(22)15(10-23)18(19)28-7-5-6-8-28)13(3)29-21-17(12(2)27-29)20(24)25-11-26-21/h9,11,13H,4-8H2,1-3H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289318
PNG
(US10092570, Example 322 | US9730939, Example 322 |...)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(C1)C(=O)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H31N7O3/c1-7-35-21-17(15(4)32-23-19(14(3)30-32)22(27)28-12-29-23)8-13(2)18(9-26)20(21)16-10-31(11-16)24(33)25(5,6)34/h8,12,15-16,34H,7,10-11H2,1-6H3,(H2,27,28,29)
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261324
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H21ClN6O3/c1-8-12(20)5-11(16(28-4)14(8)13-6-22-19(27)29-13)10(3)26-18-15(9(2)25-26)17(21)23-7-24-18/h5,7,10,13H,6H2,1-4H3,(H,22,27)(H2,21,23,24)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255807
PNG
(4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)NCCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H26ClN7O3/c1-12-17(25)10-16(14(3)32-23-20(13(2)31-32)22(26)29-11-30-23)21(35-4)19(12)15-5-6-27-18(9-15)24(34)28-7-8-33/h5-6,9-11,14,33H,7-8H2,1-4H3,(H,28,34)(H2,26,29,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255811
PNG
(3′-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(C(=O)N(C)C)c(F)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H26ClFN6O2/c1-12-18(26)10-17(14(3)33-24-21(13(2)31-33)23(28)29-11-30-24)22(35-6)20(12)15-7-8-16(19(27)9-15)25(34)32(4)5/h7-11,14H,1-6H3,(H2,28,29,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255835
PNG
(5-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H25ClN8O2/c1-6-36-22-16(14(3)34-24-20(13(2)32-34)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(35)33(4)5/h7-9,11-12,14H,6H2,1-5H3,(H2,28,30,31)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261072
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H29ClN6O2/c1-5-31-20-16(8-17(23)12(2)18(20)15-9-28(10-15)6-7-30)14(4)29-22-19(13(3)27-29)21(24)25-11-26-22/h8,11,14-15,30H,5-7,9-10H2,1-4H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261133
PNG
((2R)-2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)[C@H](C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H29ClN6O2/c1-11(9-30)28-7-15(8-28)18-12(2)17(23)6-16(20(18)31-5)14(4)29-22-19(13(3)27-29)21(24)25-10-26-22/h6,10-11,14-15,30H,7-9H2,1-5H3,(H2,24,25,26)/t11-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261135
PNG
(1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H31ClN6O2/c1-12-17(24)7-16(14(3)30-22-19(13(2)28-30)21(25)26-11-27-22)20(32-6)18(12)15-8-29(9-15)10-23(4,5)31/h7,11,14-15,31H,8-10H2,1-6H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261178
PNG
(4-(3-(1-(4-amino-3-methyl-1H- pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccnc(c1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H26ClN7O2/c1-12-17(25)10-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-27-18(9-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM334051
PNG
(2-(4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES CCOc1c(cc(Cl)c(C)c1-c1cnn(CC(N)=O)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H25ClN8O2/c1-5-33-20-15(13(4)31-22-19(12(3)29-31)21(25)26-10-27-22)6-16(23)11(2)18(20)14-7-28-30(8-14)9-17(24)32/h6-8,10,13H,5,9H2,1-4H3,(H2,24,32)(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261262
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)S(C)(=O)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H22ClN7O3S/c1-10-16-19(23)24-9-25-20(16)28(26-10)11(2)13-5-15(21)14(6-22)17(18(13)31-3)12-7-27(8-12)32(4,29)30/h5,9,11-12H,7-8H2,1-4H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261270
PNG
(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(N)=O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H21ClN8O2/c1-9-15-18(23)25-8-26-19(15)29(27-9)10(2)12-4-14(21)13(5-22)16(17(12)31-3)11-6-28(7-11)20(24)30/h4,8,10-11H,6-7H2,1-3H3,(H2,24,30)(H2,23,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261294
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(C)c(C#N)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H31N7O/c1-7-32-22-18(16(6)31-24-20(15(5)29-31)23(26)27-12-28-24)8-14(4)19(9-25)21(22)17-10-30(11-17)13(2)3/h8,12-13,16-17H,7,10-11H2,1-6H3,(H2,26,27,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM334185
PNG
(Diastereoisomers of 4-{3-[1-(4-amino-3-methyl-1H-p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CNC(=O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H25ClN6O2/c1-5-30-19-14(7-15(22)10(2)17(19)13-6-16(29)24-8-13)12(4)28-21-18(11(3)27-28)20(23)25-9-26-21/h7,9,12-13H,5-6,8H2,1-4H3,(H,24,29)(H2,23,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM334185
PNG
(Diastereoisomers of 4-{3-[1-(4-amino-3-methyl-1H-p...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CNC(=O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H25ClN6O2/c1-5-30-19-14(7-15(22)10(2)17(19)13-6-16(29)24-8-13)12(4)28-21-18(11(3)27-28)20(23)25-9-26-21/h7,9,12-13H,5-6,8H2,1-4H3,(H,24,29)(H2,23,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261320
PNG
(US10092570, Example 323 | US9707233, 323 (3rd peak...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CNC(=O)O1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H20ClN7O3/c1-4-30-17-11(5-13(21)12(6-22)16(17)14-7-24-20(29)31-14)10(3)28-19-15(9(2)27-28)18(23)25-8-26-19/h5,8,10,14H,4,7H2,1-3H3,(H,24,29)(H2,23,25,26)
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289347
PNG
(US10092570, Example 349 | US9932341, Example 349)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1[C@@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H22ClN7O2/c1-4-31-19-13(6-15(22)14(7-23)18(19)12-5-16(30)25-8-12)11(3)29-21-17(10(2)28-29)20(24)26-9-27-21/h6,9,11-12H,4-5,8H2,1-3H3,(H,25,30)(H2,24,26,27)/t11-,12+/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255796
PNG
(1-{1-[5-Chloro-3-(1-isobutylazetidin-3-yl)-2-metho...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(CC(C)C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H31ClN6O/c1-12(2)8-29-9-16(10-29)19-13(3)18(24)7-17(21(19)31-6)15(5)30-23-20(14(4)28-30)22(25)26-11-27-23/h7,11-12,15-16H,8-10H2,1-6H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255797
PNG
(1-{1-[3-(1-sec-butylazetidin-3-yl)-5-chloro-2-meth...)
Show SMILES CCC(C)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1/C23H31ClN6O/c1-7-12(2)29-9-16(10-29)19-13(3)18(24)8-17(21(19)31-6)15(5)30-23-20(14(4)28-30)22(25)26-11-27-23/h8,11-12,15-16H,7,9-10H2,1-6H3,(H2,25,26,27)
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n/an/a<10n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255799
PNG
(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CNC(=O)N1CC(C1)c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1/C21H26ClN7O2/c1-10-15(22)6-14(18(31-5)16(10)13-7-28(8-13)21(30)24-4)12(3)29-20-17(11(2)27-29)19(23)25-9-26-20/h6,9,12-13H,7-8H2,1-5H3,(H,24,30)(H2,23,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255800
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H26ClN7O2/c1-12-17(25)9-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-18(27-10-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255814
PNG
(4-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H28ClN7O3/c1-13-18(26)10-17(15(3)33-24-21(14(2)31-33)23(27)29-12-30-24)22(36-5)20(13)16-6-7-19(28-11-16)25(35)32(4)8-9-34/h6-7,10-12,15,34H,8-9H2,1-5H3,(H2,27,29,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255800
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H26ClN7O2/c1-12-17(25)9-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-18(27-10-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255859
PNG
(US10092570, Example 68 | US9707233, 68 (1st peak) ...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H26ClFN6O2/c1-10(30)6-28-7-13(8-28)17-18(23)15(22)5-14(19(17)31-4)12(3)29-21-16(11(2)27-29)20(24)25-9-26-21/h5,9-10,12-13,30H,6-8H2,1-4H3,(H2,24,25,26)/t10-,12?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261076
PNG
((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES CCOc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@H](C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H29ClN6O3/c1-6-33-20-16(13(4)30-22-19(12(3)28-30)21(25)26-10-27-22)7-17(24)11(2)18(20)15-8-29(9-15)23(32)14(5)31/h7,10,13-15,31H,6,8-9H2,1-5H3,(H2,25,26,27)/t13?,14-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261118
PNG
(1-(1-{5-Chloro-2-ethoxy-4-fluoro-3-[1-(2,2,2-trifl...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(CC(F)(F)F)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H23ClF4N6O/c1-4-33-18-13(11(3)32-20-15(10(2)30-32)19(27)28-9-29-20)5-14(22)17(23)16(18)12-6-31(7-12)8-21(24,25)26/h5,9,11-12H,4,6-8H2,1-3H3,(H2,27,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261197
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H28ClN7O2/c1-5-33-21-16(14(4)31-23-19(13(3)29-31)22(26)27-11-28-23)6-18(24)17(7-25)20(21)15-9-30(10-15)8-12(2)32/h6,11-12,14-15,32H,5,8-10H2,1-4H3,(H2,26,27,28)/t12-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261238
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CNC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H20ClN7O/c1-9-15-18(22)24-8-25-19(15)27(26-9)10(2)12-4-14(20)13(5-21)16(17(12)28-3)11-6-23-7-11/h4,8,10-11,23H,6-7H2,1-3H3,(H2,22,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM334118
PNG
(Diastereoisomers of 4-[1-(4-amino-3-methyl-1H-pyra...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C1)C(C)CO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClN7O2/c1-11(9-31)29-7-14(8-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289297
PNG
(US10092570, Example 298 | US9730939, Example 298 |...)
Show SMILES CCN1CC(C1)c1c(Cl)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1/C20H24Cl2N6O/c1-5-27-7-12(8-27)16-17(22)14(21)6-13(18(16)29-4)11(3)28-20-15(10(2)26-28)19(23)24-9-25-20/h6,9,11-12H,5,7-8H2,1-4H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261289
PNG
(4-[-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidi...)
Show SMILES COc1c(cc(C)c(C#N)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H29N7O2/c1-12-6-17(15(4)30-23-19(14(3)28-30)22(25)26-11-27-23)21(32-5)20(18(12)7-24)16-9-29(10-16)8-13(2)31/h6,11,13,15-16,31H,8-10H2,1-5H3,(H2,25,26,27)/t13-,15?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261290
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1-c1ccc(nc1)C(C)(C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C25H26ClN7O2/c1-6-35-22-16(14(3)33-24-20(13(2)32-33)23(28)30-12-31-24)9-18(26)17(10-27)21(22)15-7-8-19(29-11-15)25(4,5)34/h7-9,11-12,14,34H,6H2,1-5H3,(H2,28,30,31)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261293
PNG
(4-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1N1CC(C1)OC)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClN7O2/c1-5-31-19-14(6-16(22)15(7-23)18(19)28-8-13(9-28)30-4)12(3)29-21-17(11(2)27-29)20(24)25-10-26-21/h6,10,12-13H,5,8-9H2,1-4H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM272573
PNG
(US10065963, 32c | US9932341, Example 347)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM384657
PNG
(US9932341, Example 352)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1[C@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O2/c1-4-31-19-13(6-15(22)14(7-23)18(19)12-5-16(30)25-8-12)11(3)29-21-17(10(2)28-29)20(24)26-9-27-21/h6,9,11-12H,4-5,8H2,1-3H3,(H,25,30)(H2,24,26,27)/t11-,12+/m0/s1
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM384664
PNG
(4-((5)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrim...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@H](C)O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)/t11-,13-/m0/s1
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255802
PNG
(1-{1-[5-Chloro-4-fluoro-3-(1-isopropylazetidin-3-y...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C1)C(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H26ClFN6O/c1-10(2)28-7-13(8-28)17-18(23)15(22)6-14(19(17)30-5)12(4)29-21-16(11(3)27-29)20(24)25-9-26-21/h6,9-10,12-13H,7-8H2,1-5H3,(H2,24,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255863
PNG
(1-{1-[5-Chloro-4-fluoro-2-methoxy-3-(1-oxetan-3-yl...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(C)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H22ClFN6O/c1-9-14-18(22)23-8-24-19(14)27(25-9)10(2)12-5-13(20)16(21)15(17(12)28-4)11-6-26(3)7-11/h5,8,10-11H,6-7H2,1-4H3,(H2,22,23,24)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261117
PNG
(1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(CC(C)(C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C23H30ClFN6O2/c1-6-33-20-15(13(3)31-22-17(12(2)29-31)21(26)27-11-28-22)7-16(24)19(25)18(20)14-8-30(9-14)10-23(4,5)32/h7,11,13-14,32H,6,8-10H2,1-5H3,(H2,26,27,28)
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261120
PNG
((2S)-1-(3-{3-[1-(4-Amino-3- methyl-1H-pyrazolo[3,4...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H28ClFN6O2/c1-5-32-20-15(13(4)30-22-17(12(3)28-30)21(25)26-10-27-22)6-16(23)19(24)18(20)14-8-29(9-14)7-11(2)31/h6,10-11,13-14,31H,5,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/s2
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261136
PNG
((2R)-2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)[C@H](C)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H32ClN7O2/c1-12-18(25)8-17(14(3)32-23-20(13(2)29-32)22(26)27-11-28-23)21(34-7)19(12)16-9-31(10-16)15(4)24(33)30(5)6/h8,11,14-16H,9-10H2,1-7H3,(H2,26,27,28)/t14?,15-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255800
PNG
(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C24H26ClN7O2/c1-12-17(25)9-16(14(3)32-23-20(13(2)30-32)22(26)28-11-29-23)21(34-6)19(12)15-7-8-18(27-10-15)24(33)31(4)5/h7-11,14H,1-6H3,(H2,26,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261145
PNG
(1-(1-(5-chloro-2-methoxy-4- methyl-3-(pyrimidin-5-...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cncnc1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H20ClN7O/c1-10-15(21)5-14(18(29-4)16(10)13-6-23-8-24-7-13)12(3)28-20-17(11(2)27-28)19(22)25-9-26-20/h5-9,12H,1-4H3,(H2,22,25,26)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261196
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClN7O2/c1-4-32-20-15(13(3)30-22-18(12(2)28-30)21(25)26-11-27-22)7-17(23)16(8-24)19(20)14-9-29(10-14)5-6-31/h7,11,13-14,31H,4-6,9-10H2,1-3H3,(H2,25,26,27)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261246
PNG
(4-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)/t11-,13?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289354
PNG
(US10092570, Example 356 | US9932341, Example 357)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)O1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-23-19(28)30-12)9(3)27-18-13(8(2)26-27)17(22)24-7-25-18/h5,7,9,12H,4,6H2,1-3H3,(H,23,28)(H2,22,24,25)/t9-,12+/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255806
PNG
(4-(3-(1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CNC(=O)c1cc(ccn1)-c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1/C23H24ClN7O2/c1-11-16(24)9-15(13(3)31-22-19(12(2)30-31)21(25)28-10-29-22)20(33-5)18(11)14-6-7-27-17(8-14)23(32)26-4/h6-10,13H,1-5H3,(H,26,32)(H2,25,28,29)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255812
PNG
(3′-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]py...)
Show SMILES CNC(=O)c1ccc(cc1F)-c1c(C)c(Cl)cc(C(C)n2nc(C)c3c(N)ncnc23)c1OC
Show InChI InChI=1/C24H24ClFN6O2/c1-11-17(25)9-16(13(3)32-23-20(12(2)31-32)22(27)29-10-30-23)21(34-5)19(11)14-6-7-15(18(26)8-14)24(33)28-4/h6-10,13H,1-5H3,(H,28,33)(H2,27,29,30)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255862
PNG
(2-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyr...)
Show SMILES COc1c(cc(Cl)c(F)c1C1CN(CCO)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H24ClFN6O2/c1-10-15-19(23)24-9-25-20(15)28(26-10)11(2)13-6-14(21)17(22)16(18(13)30-3)12-7-27(8-12)4-5-29/h6,9,11-12,29H,4-5,7-8H2,1-3H3,(H2,23,24,25)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261079
PNG
((2S)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C[C@@H](C)O)C1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H29ClN6O2/c1-11(30)7-28-8-15(9-28)18-12(2)17(23)6-16(20(18)31-5)14(4)29-22-19(13(3)27-29)21(24)25-10-26-22/h6,10-11,14-15,30H,7-9H2,1-5H3,(H2,24,25,26)/t11-,14?/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261098
PNG
((2R)-1-(3-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CN(C1)C(=O)[C@@H](C)O)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H27ClN6O3/c1-10-16(23)6-15(12(3)29-21-18(11(2)27-29)20(24)25-9-26-21)19(32-5)17(10)14-7-28(8-14)22(31)13(4)30/h6,9,12-14,30H,7-8H2,1-5H3,(H2,24,25,26)/t12?,13-/s2
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM384607
PNG
(2-[(5-{3-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]py...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(NCCO)nc1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C23H26ClN7O2/c1-12-17(24)9-16(14(3)31-23-20(13(2)30-31)22(25)28-11-29-23)21(33-4)19(12)15-5-6-18(27-10-15)26-7-8-32/h5-6,9-11,14,32H,7-8H2,1-4H3,(H,26,27)(H2,25,28,29)
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM384610
PNG
(1-[1-(5-Chloro-3-cyclopropyl-2-methoxy-4-methylphe...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CC1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H22ClN5O/c1-9-14(20)7-13(17(26-4)15(9)12-5-6-12)11(3)25-19-16(10(2)24-25)18(21)22-8-23-19/h7-8,11-12H,5-6H2,1-4H3,(H2,21,22,23)
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US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261186
PNG
(5-[1-(4-Amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin...)
Show SMILES COc1c(cc(C#N)c(C)c1-c1cnn(C)c1)C(C)Nc1ncnc(N)c1C(C)=N
Show InChI InChI=1/C21H24N8O/c1-11-14(7-22)6-16(19(30-5)17(11)15-8-27-29(4)9-15)13(3)28-21-18(12(2)23)20(24)25-10-26-21/h6,8-10,13,23H,1-5H3,(H3,24,25,26,28)
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Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM255831
PNG
(4-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES COc1c(cc(C#N)c(C)c1-c1ccnc(c1)C(=O)N(C)CCO)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C26H28N8O3/c1-14-18(12-27)10-19(16(3)34-25-22(15(2)32-34)24(28)30-13-31-25)23(37-5)21(14)17-6-7-29-20(11-17)26(36)33(4)8-9-35/h6-7,10-11,13,16,35H,8-9H2,1-5H3,(H2,28,30,31)
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US Patent
n/an/a 30n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289040
PNG
(US10092570, Example 41 | US9730939, Example 41 | U...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1ccc(nc1)C(=O)N(C)C)C(C)n1nc(C)c2c(N)nccc12
Show InChI InChI=1/C25H27ClN6O2/c1-13-18(26)11-17(15(3)32-20-9-10-28-24(27)22(20)14(2)30-32)23(34-6)21(13)16-7-8-19(29-12-16)25(33)31(4)5/h7-12,15H,1-6H3,(H2,27,28)
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n/an/a 125n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM384660
PNG
(5-{3-[1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimi...)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)O1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-23-19(28)30-12)9(3)27-18-13(8(2)26-27)17(22)24-7-25-18/h5,7,9,12H,4,6H2,1-3H3,(H,23,28)(H2,22,24,25)/t9-,12-/m1/s1
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n/an/a 125n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261342
PNG
(US9707233, 361 | US9932341, Example 363)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@H](C)O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)/t11-,13+/s2
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n/an/a 125n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM384661
PNG
(US9932341, Example 356)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)O1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-23-19(28)30-12)9(3)27-18-13(8(2)26-27)17(22)24-7-25-18/h5,7,9,12H,4,6H2,1-3H3,(H,23,28)(H2,22,24,25)/t9-,12+/m1/s1
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n/an/a 125n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289348
PNG
(US10092570, Example 350 | US9932341, Example 351)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1[C@@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H22ClN7O2/c1-4-31-19-13(6-15(22)14(7-23)18(19)12-5-16(30)25-8-12)11(3)29-21-17(10(2)28-29)20(24)26-9-27-21/h6,9,11-12H,4-5,8H2,1-3H3,(H,25,30)(H2,24,26,27)/t11-,12-/s2
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n/an/a 125n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM272574
PNG
(US10065963, Compound 32d | US9932341, Example 348)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@H]1CNC(=O)C1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11+/s2
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n/an/a 125n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289019
PNG
(US10092570, Example 20 | US9730939, Example 20 | U...)
Show SMILES COc1c(cc(Cl)c(C)c1-c1cnn(CCO)c1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C21H24ClN7O2/c1-11-16(22)7-15(19(31-4)17(11)14-8-26-28(9-14)5-6-30)13(3)29-21-18(12(2)27-29)20(23)24-10-25-21/h7-10,13,30H,5-6H2,1-4H3,(H2,23,24,25)
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n/an/a 125n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM272571
PNG
(US10065963, Compound 32a | US9932341, Example 345)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H22ClFN6O2/c1-4-30-18-12(6-13(21)17(22)16(18)11-5-14(29)24-7-11)10(3)28-20-15(9(2)27-28)19(23)25-8-26-20/h6,8,10-11H,4-5,7H2,1-3H3,(H,24,29)(H2,23,25,26)/t10-,11+/s2
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n/an/a 125n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM289341
PNG
(US10092570, Example 324 | US9730939, Example 324 |...)
Show SMILES COc1c(cc(Cl)c(C)c1C1CNC(=O)CO1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C20H23ClN6O3/c1-9-13(21)5-12(18(29-4)16(9)14-6-23-15(28)7-30-14)11(3)27-20-17(10(2)26-27)19(22)24-8-25-20/h5,8,11,14H,6-7H2,1-4H3,(H,23,28)(H2,22,24,25)
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n/an/a 125n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM261343
PNG
(US9707233, 363 | US9932341, Example 361)
Show SMILES COc1c(cc(Cl)c(C#N)c1C1CN(C[C@@H](C)O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C22H26ClN7O2/c1-11(31)7-29-8-14(9-29)19-16(6-24)17(23)5-15(20(19)32-4)13(3)30-22-18(12(2)28-30)21(25)26-10-27-22/h5,10-11,13-14,31H,7-9H2,1-4H3,(H2,25,26,27)/t11-,13-/s2
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n/an/a>500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM384655
PNG
(US9932341, Example 350)
Show SMILES CCOc1c(cc(Cl)c(C#N)c1[C@H]1CNC(=O)C1)[C@@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C21H22ClN7O2/c1-4-31-19-13(6-15(22)14(7-23)18(19)12-5-16(30)25-8-12)11(3)29-21-17(10(2)28-29)20(24)26-9-27-21/h6,9,11-12H,4-5,8H2,1-3H3,(H,25,30)(H2,24,26,27)/t11-,12-/m1/s1
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n/an/a>500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM334198
PNG
(Diastereomers of 4-{3-[1-(4-amino-3-methyl-1H-pyra...)
Show SMILES CCOc1c(cc(Cl)c(F)c1C1COC(=O)N1)C(C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-30-19(28)25-12)9(3)27-18-13(8(2)26-27)17(22)23-7-24-18/h5,7,9,12H,4,6H2,1-3H3,(H,25,28)(H2,22,23,24)
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n/an/a>500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM384663
PNG
(US9932341, Example 358)
Show SMILES CCOc1c(cc(Cl)c(F)c1[C@@H]1CNC(=O)O1)[C@H](C)n1nc(C)c2c(N)ncnc12
Show InChI InChI=1S/C19H20ClFN6O3/c1-4-29-16-10(5-11(20)15(21)14(16)12-6-23-19(28)30-12)9(3)27-18-13(8(2)26-27)17(22)24-7-25-18/h5,7,9,12H,4,6H2,1-3H3,(H,23,28)(H2,22,24,25)/t9-,12-/m0/s1
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n/an/a>500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 uL. Inhibitors wer...


US Patent US9932341 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%