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Patent code US9932350

Compile Data Set for Download or QSAR
Found 108 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242698
PNG
(CHEMBL4069200 | US9932350, 3-54)
Show SMILES FC1(F)CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1/C20H23F2N5/c21-20(22)7-9-27(10-8-20)16-4-2-15(3-5-16)26-19-17-11-14(12-23)1-6-18(17)24-13-25-19/h1,6,11,13,15-16H,2-5,7-10H2,(H,24,25,26)/t15-,16-
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n/an/a 3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384629
PNG
(4-({Trans-4-[4-(cyclopropylcarbonyl)piperazin-1-yl...)
Show SMILES O=C(C1CC1)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C23H28N6O/c24-14-16-1-8-21-20(13-16)22(26-15-25-21)27-18-4-6-19(7-5-18)28-9-11-29(12-10-28)23(30)17-2-3-17/h1,8,13,15,17-19H,2-7,9-12H2,(H,25,26,27)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242727
PNG
(CHEMBL4096446 | US9932350, 3-19)
Show SMILES FC1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1/C20H24FN5/c21-15-7-9-26(10-8-15)17-4-2-16(3-5-17)25-20-18-11-14(12-22)1-6-19(18)23-13-24-20/h1,6,11,13,15-17H,2-5,7-10H2,(H,23,24,25)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384582
PNG
(4-({trans-4-[(2S or 2R)- 2-methylmorpholin-4- yl]c...)
Show SMILES CC1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H25N5O/c1-14-12-25(8-9-26-14)17-5-3-16(4-6-17)24-20-18-10-15(11-21)2-7-19(18)22-13-23-20/h2,7,10,13-14,16-17H,3-6,8-9,12H2,1H3,(H,22,23,24)/t14?,16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384611
PNG
(4-({trans-4-[(3R or 3S)- 3-(morpholin-4- ylmethyl)...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCCC(CN4CCOCC4)C3)c2c1
Show InChI InChI=1S/C25H34N6O/c26-15-19-3-8-24-23(14-19)25(28-18-27-24)29-21-4-6-22(7-5-21)31-9-1-2-20(17-31)16-30-10-12-32-13-11-30/h3,8,14,18,20-22H,1-2,4-7,9-13,16-17H2,(H,27,28,29)/t20?,21-,22-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384575
PNG
(4-({trans-4-[(2R,6S)-2,6- dimethylmorpholin-4- yl]...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H27N5O/c1-14-11-26(12-15(2)27-14)18-6-4-17(5-7-18)25-21-19-9-16(10-22)3-8-20(19)23-13-24-21/h3,8-9,13-15,17-18H,4-7,11-12H2,1-2H3,(H,23,24,25)/t14-,15+,17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384550
PNG
(US9932350, 2-2)
Show SMILES Brc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C18H23BrN4O/c19-13-1-6-17-16(11-13)18(21-12-20-17)22-14-2-4-15(5-3-14)23-7-9-24-10-8-23/h1,6,11-12,14-15H,2-5,7-10H2,(H,20,21,22)/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242697
PNG
(CHEMBL4070214 | US9932350, 2-7)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1/C19H23N5O/c20-12-14-1-6-18-17(11-14)19(22-13-21-18)23-15-2-4-16(5-3-15)24-7-9-25-10-8-24/h1,6,11,13,15-16H,2-5,7-10H2,(H,21,22,23)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384615
PNG
(US9932350, 3-45 | tert-butyl 4-{trans-4-[(6- cyano...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H32N6O2/c1-24(2,3)32-23(31)30-12-10-29(11-13-30)19-7-5-18(6-8-19)28-22-20-14-17(15-25)4-9-21(20)26-16-27-22/h4,9,14,16,18-19H,5-8,10-13H2,1-3H3,(H,26,27,28)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384577
PNG
(4-({trans-4-[(2R or 2S)- 2- (hydroxymethyl)morphol...)
Show SMILES OCC1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H25N5O2/c21-10-14-1-6-19-18(9-14)20(23-13-22-19)24-15-2-4-16(5-3-15)25-7-8-27-17(11-25)12-26/h1,6,9,13,15-17,26H,2-5,7-8,11-12H2,(H,22,23,24)/t15-,16-,17?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384561
PNG
(6-chloro-N-[trans-4- (morpholin-4- yl)cyclohexyl]q...)
Show SMILES Clc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C18H23ClN4O/c19-13-1-6-17-16(11-13)18(21-12-20-17)22-14-2-4-15(5-3-14)23-7-9-24-10-8-23/h1,6,11-12,14-15H,2-5,7-10H2,(H,20,21,22)/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384569
PNG
(4-({cis or trans-4-[(3R or S)-3- (trifluoromethyl)...)
Show SMILES FC(F)(F)C1CCCN(C1)C1CCC(CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H24F3N5/c22-21(23,24)15-2-1-9-29(12-15)17-6-4-16(5-7-17)28-20-18-10-14(11-25)3-8-19(18)26-13-27-20/h3,8,10,13,15-17H,1-2,4-7,9,12H2,(H,26,27,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384616
PNG
(4-({trans-4-[3- (morpholin-4- ylmethyl)piperidin-1...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCCC(CN4CCOCC4)C3)c2c1
Show InChI InChI=1S/C25H34N6O/c26-15-19-3-8-24-23(14-19)25(28-18-27-24)29-21-4-6-22(7-5-21)31-9-1-2-20(17-31)16-30-10-12-32-13-11-30/h3,8,14,18,20-22H,1-2,4-7,9-13,16-17H2,(H,27,28,29)/t20?,21-,22-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384656
PNG
(4-{[(1S,2S,5S,6R)-5-(4- fluoropiperidin-1- yl)bicy...)
Show SMILES FC1CCN(CC1)[C@H]1CC[C@H](Nc2ncnc3ccc(cc23)C#N)[C@H]2C[C@@H]12
Show InChI InChI=1S/C21H24FN5/c22-14-5-7-27(8-6-14)20-4-3-19(15-10-16(15)20)26-21-17-9-13(11-23)1-2-18(17)24-12-25-21/h1-2,9,12,14-16,19-20H,3-8,10H2,(H,24,25,26)/t15-,16+,19-,20-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384577
PNG
(4-({trans-4-[(2R or 2S)- 2- (hydroxymethyl)morphol...)
Show SMILES OCC1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H25N5O2/c21-10-14-1-6-19-18(9-14)20(23-13-22-19)24-15-2-4-16(5-3-15)25-7-8-27-17(11-25)12-26/h1,6,9,13,15-17,26H,2-5,7-8,11-12H2,(H,22,23,24)/t15-,16-,17?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242696
PNG
(CHEMBL4083650 | US9932350, 2-5)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1/C17H21N5/c1-22(2)14-6-4-13(5-7-14)21-17-15-9-12(10-18)3-8-16(15)19-11-20-17/h3,8-9,11,13-14H,4-7H2,1-2H3,(H,19,20,21)/t13-,14-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384582
PNG
(4-({trans-4-[(2S or 2R)- 2-methylmorpholin-4- yl]c...)
Show SMILES CC1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H25N5O/c1-14-12-25(8-9-26-14)17-5-3-16(4-6-17)24-20-18-10-15(11-21)2-7-19(18)22-13-23-20/h2,7,10,13-14,16-17H,3-6,8-9,12H2,1H3,(H,22,23,24)/t14?,16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384648
PNG
(4-[(trans-4-{4- [cyclopropyl(hydroxy) acetyl]piper...)
Show SMILES OC(C1CC1)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H30N6O2/c25-14-16-1-8-21-20(13-16)23(27-15-26-21)28-18-4-6-19(7-5-18)29-9-11-30(12-10-29)24(32)22(31)17-2-3-17/h1,8,13,15,17-19,22,31H,2-7,9-12H2,(H,26,27,28)/t18-,19-,22?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384631
PNG
(4-({trans-4-[4-(2,2- dimethylpropanoyl) piperazin-...)
Show SMILES CC(C)(C)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H32N6O/c1-24(2,3)23(31)30-12-10-29(11-13-30)19-7-5-18(6-8-19)28-22-20-14-17(15-25)4-9-21(20)26-16-27-22/h4,9,14,16,18-19H,5-8,10-13H2,1-3H3,(H,26,27,28)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242700
PNG
(CHEMBL4088745 | US9932350, 3-20)
Show SMILES CS(=O)(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1/C20H26N6O2S/c1-29(27,28)26-10-8-25(9-11-26)17-5-3-16(4-6-17)24-20-18-12-15(13-21)2-7-19(18)22-14-23-20/h2,7,12,14,16-17H,3-6,8-11H2,1H3,(H,22,23,24)/t16-,17-
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n/an/a 8n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384593
PNG
(4-({trans-4-[2- (fluoromethyl)morpholin- 4- yl]cyc...)
Show SMILES FCC1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H24FN5O/c21-10-17-12-26(7-8-27-17)16-4-2-15(3-5-16)25-20-18-9-14(11-22)1-6-19(18)23-13-24-20/h1,6,9,13,15-17H,2-5,7-8,10,12H2,(H,23,24,25)/t15-,16-,17?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384632
PNG
(4-({trans-4-[4-(3-fluoro- 2,2- dimethylpropanoyl) ...)
Show SMILES CC(C)(CF)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H31FN6O/c1-24(2,15-25)23(32)31-11-9-30(10-12-31)19-6-4-18(5-7-19)29-22-20-13-17(14-26)3-8-21(20)27-16-28-22/h3,8,13,16,18-19H,4-7,9-12,15H2,1-2H3,(H,27,28,29)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384650
PNG
(4-({trans-4-[4-(3- hydroxypropanoyl) piperazin-1- ...)
Show SMILES OCCC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C22H28N6O2/c23-14-16-1-6-20-19(13-16)22(25-15-24-20)26-17-2-4-18(5-3-17)27-8-10-28(11-9-27)21(30)7-12-29/h1,6,13,15,17-18,29H,2-5,7-12H2,(H,24,25,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384645
PNG
(4-({trans-4-[4- (cyclopropylacetyl) piperazin-1- y...)
Show SMILES O=C(CC1CC1)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H30N6O/c25-15-18-3-8-22-21(13-18)24(27-16-26-22)28-19-4-6-20(7-5-19)29-9-11-30(12-10-29)23(31)14-17-1-2-17/h3,8,13,16-17,19-20H,1-2,4-7,9-12,14H2,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242695
PNG
(CHEMBL4068395 | US9932350, 2-6)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(Br)cc12
Show InChI InChI=1/C16H21BrN4/c1-21(2)13-6-4-12(5-7-13)20-16-14-9-11(17)3-8-15(14)18-10-19-16/h3,8-10,12-13H,4-7H2,1-2H3,(H,18,19,20)/t12-,13-
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US Patent
n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384613
PNG
(4-({trans-4-[4- (mopholin-4- ylmethyl)piperidin-1-...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(CN4CCOCC4)CC3)c2c1
Show InChI InChI=1S/C25H34N6O/c26-16-20-1-6-24-23(15-20)25(28-18-27-24)29-21-2-4-22(5-3-21)31-9-7-19(8-10-31)17-30-11-13-32-14-12-30/h1,6,15,18-19,21-22H,2-5,7-14,17H2,(H,27,28,29)/t21-,22-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384597
PNG
(4-({trans-4-[(3R)-3- methylmorpholin-4- yl]cyclohe...)
Show SMILES C[C@@H]1COCCN1[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H25N5O/c1-14-12-26-9-8-25(14)17-5-3-16(4-6-17)24-20-18-10-15(11-21)2-7-19(18)22-13-23-20/h2,7,10,13-14,16-17H,3-6,8-9,12H2,1H3,(H,22,23,24)/t14-,16-,17-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384641
PNG
(4-[(trans-4-{4-[(3- fluorocyclobutyl)carbonyl] pip...)
Show SMILES FC1CC(C1)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H29FN6O/c25-18-12-17(13-18)24(32)31-9-7-30(8-10-31)20-4-2-19(3-5-20)29-23-21-11-16(14-26)1-6-22(21)27-15-28-23/h1,6,11,15,17-20H,2-5,7-10,12-13H2,(H,27,28,29)/t17?,18?,19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384649
PNG
(4-[(trans-4-{4-[(3- hydroxycyclobutyl) carbonyl]pi...)
Show SMILES OC1CC(C1)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H30N6O2/c25-14-16-1-6-22-21(11-16)23(27-15-26-22)28-18-2-4-19(5-3-18)29-7-9-30(10-8-29)24(32)17-12-20(31)13-17/h1,6,11,15,17-20,31H,2-5,7-10,12-13H2,(H,26,27,28)/t17?,18-,19-,20?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384659
PNG
(4-{[(1S,2S,4S or 1R,2R,4R)-4-(4- fluoropiperidin-1...)
Show SMILES CC1CC(CCC1Nc1ncnc2ccc(cc12)C#N)N1CCC(F)CC1
Show InChI InChI=1S/C21H26FN5/c1-14-10-17(27-8-6-16(22)7-9-27)3-5-19(14)26-21-18-11-15(12-23)2-4-20(18)24-13-25-21/h2,4,11,13-14,16-17,19H,3,5-10H2,1H3,(H,24,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384644
PNG
(4-({trans-4-[4- (cyclopentylcarbonyl) piperazin-1-...)
Show SMILES O=C(C1CCCC1)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C25H32N6O/c26-16-18-5-10-23-22(15-18)24(28-17-27-23)29-20-6-8-21(9-7-20)30-11-13-31(14-12-30)25(32)19-3-1-2-4-19/h5,10,15,17,19-21H,1-4,6-9,11-14H2,(H,27,28,29)/t20-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384646
PNG
(4-({trans-4-[4-(oxetan-3- ylacetyl)piperazin-1- yl...)
Show SMILES O=C(CC1COC1)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H30N6O2/c25-13-17-1-6-22-21(11-17)24(27-16-26-22)28-19-2-4-20(5-3-19)29-7-9-30(10-8-29)23(31)12-18-14-32-15-18/h1,6,11,16,18-20H,2-5,7-10,12,14-15H2,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384643
PNG
(4-({trans-4-[4- (cyclobutylcarbonyl) piperazin-1- ...)
Show SMILES O=C(C1CCC1)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H30N6O/c25-15-17-4-9-22-21(14-17)23(27-16-26-22)28-19-5-7-20(8-6-19)29-10-12-30(13-11-29)24(31)18-2-1-3-18/h4,9,14,16,18-20H,1-3,5-8,10-13H2,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384595
PNG
(4-{[trans-4-(3- methoxyazetidin-1- yl)cyclohexyl]a...)
Show SMILES COC1CN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C19H23N5O/c1-25-16-10-24(11-16)15-5-3-14(4-6-15)23-19-17-8-13(9-20)2-7-18(17)21-12-22-19/h2,7-8,12,14-16H,3-6,10-11H2,1H3,(H,21,22,23)/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384639
PNG
(4-[(trans-4-{4-[(2S)- tetrahydrofuran-2- ylcarbony...)
Show SMILES O=C([C@@H]1CCCO1)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H30N6O2/c25-15-17-3-8-21-20(14-17)23(27-16-26-21)28-18-4-6-19(7-5-18)29-9-11-30(12-10-29)24(31)22-2-1-13-32-22/h3,8,14,16,18-19,22H,1-2,4-7,9-13H2,(H,26,27,28)/t18-,19-,22-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384630
PNG
(4-{[trans-4-(4- acetylpiperazin-1- yl)cyclohexyl]a...)
Show SMILES CC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H26N6O/c1-15(28)26-8-10-27(11-9-26)18-5-3-17(4-6-18)25-21-19-12-16(13-22)2-7-20(19)23-14-24-21/h2,7,12,14,17-18H,3-6,8-11H2,1H3,(H,23,24,25)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384590
PNG
(4-({trans-4-[(4aS,7aS or 4aR,7aR)- hexahydrocyclop...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOC4CCCC34)c2c1
Show InChI InChI=1S/C22H27N5O/c23-13-15-4-9-19-18(12-15)22(25-14-24-19)26-16-5-7-17(8-6-16)27-10-11-28-21-3-1-2-20(21)27/h4,9,12,14,16-17,20-21H,1-3,5-8,10-11H2,(H,24,25,26)/t16-,17-,20?,21?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384576
PNG
(4-({trans-4-[4- (methylsulfonyl)piperidin- 1- yl]c...)
Show SMILES CS(=O)(=O)C1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H27N5O2S/c1-29(27,28)18-8-10-26(11-9-18)17-5-3-16(4-6-17)25-21-19-12-15(13-22)2-7-20(19)23-14-24-21/h2,7,12,14,16-18H,3-6,8-11H2,1H3,(H,23,24,25)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384563
PNG
(US9932350, 2-15 | [(4-{[trans-4- (dimethylamino)cy...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(OCC#N)cc12
Show InChI InChI=1S/C18H23N5O/c1-23(2)14-5-3-13(4-6-14)22-18-16-11-15(24-10-9-19)7-8-17(16)20-12-21-18/h7-8,11-14H,3-6,10H2,1-2H3,(H,20,21,22)/t13-,14-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384623
PNG
(4-{[trans-4-(4,4- difluoroazepan-1- yl)cyclohexyl]...)
Show SMILES FC1(F)CCCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H25F2N5/c22-21(23)8-1-10-28(11-9-21)17-5-3-16(4-6-17)27-20-18-12-15(13-24)2-7-19(18)25-14-26-20/h2,7,12,14,16-17H,1,3-6,8-11H2,(H,25,26,27)/t16-,17-
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Merck Sharp & Dohme Corp.

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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384633
PNG
(4-({trans-4-[4-(2-fluoro- 2- methylpropanoyl)piper...)
Show SMILES CC(C)(F)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C23H29FN6O/c1-23(2,24)22(31)30-11-9-29(10-12-30)18-6-4-17(5-7-18)28-21-19-13-16(14-25)3-8-20(19)26-15-27-21/h3,8,13,15,17-18H,4-7,9-12H2,1-2H3,(H,26,27,28)/t17-,18-
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n/an/a 12n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384642
PNG
(4-[(trans-4-{4-[(2,2- difluorocyclopropyl) carbony...)
Show SMILES FC1(F)CC1C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C23H26F2N6O/c24-23(25)12-19(23)22(32)31-9-7-30(8-10-31)17-4-2-16(3-5-17)29-21-18-11-15(13-26)1-6-20(18)27-14-28-21/h1,6,11,14,16-17,19H,2-5,7-10,12H2,(H,27,28,29)/t16-,17-,19?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384635
PNG
(4-({trans-4-[4-(2- fluoropropanoyl)piperazin- 1- y...)
Show SMILES CC(F)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C22H27FN6O/c1-15(23)22(30)29-10-8-28(9-11-29)18-5-3-17(4-6-18)27-21-19-12-16(13-24)2-7-20(19)25-14-26-21/h2,7,12,14-15,17-18H,3-6,8-11H2,1H3,(H,25,26,27)/t15?,17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384637
PNG
(4-[(trans-4-{4-[(3- methyloxetan-3- yl)carbonyl]pi...)
Show SMILES CC1(COC1)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H30N6O2/c1-24(14-32-15-24)23(31)30-10-8-29(9-11-30)19-5-3-18(4-6-19)28-22-20-12-17(13-25)2-7-21(20)26-16-27-22/h2,7,12,16,18-19H,3-6,8-11,14-15H2,1H3,(H,26,27,28)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384579
PNG
(4-({trans-4-[3- (methylsulfonyl)pyrrolidin- 1- yl]...)
Show SMILES CS(=O)(=O)C1CCN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H25N5O2S/c1-28(26,27)17-8-9-25(12-17)16-5-3-15(4-6-16)24-20-18-10-14(11-21)2-7-19(18)22-13-23-20/h2,7,10,13,15-17H,3-6,8-9,12H2,1H3,(H,22,23,24)/t15-,16-,17?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384658
PNG
(US9932350, 8-1)
Show SMILES C[C@H]1C[C@H](CC[C@@H]1Nc1ncnc2ccc(cc12)C#N)N1CCOCC1
Show InChI InChI=1S/C20H25N5O/c1-14-10-16(25-6-8-26-9-7-25)3-5-18(14)24-20-17-11-15(12-21)2-4-19(17)22-13-23-20/h2,4,11,13-14,16,18H,3,5-10H2,1H3,(H,22,23,24)/t14-,16-,18-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242701
PNG
(CHEMBL4059675 | US9932350, 3-44)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCCC3)c2c1
Show InChI InChI=1/C19H23N5/c20-12-14-3-8-18-17(11-14)19(22-13-21-18)23-15-4-6-16(7-5-15)24-9-1-2-10-24/h3,8,11,13,15-16H,1-2,4-7,9-10H2,(H,21,22,23)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384604
PNG
(4-({trans-4-[(3R)-3- hydroxypyrrolidin-1- yl]cyclo...)
Show SMILES O[C@@H]1CCN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C19H23N5O/c20-10-13-1-6-18-17(9-13)19(22-12-21-18)23-14-2-4-15(5-3-14)24-8-7-16(25)11-24/h1,6,9,12,14-16,25H,2-5,7-8,11H2,(H,21,22,23)/t14-,15-,16-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384636
PNG
(4-[(trans-4-{4-[(1- methylcyclopropyl) carbonyl]pi...)
Show SMILES CC1(CC1)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C24H30N6O/c1-24(8-9-24)23(31)30-12-10-29(11-13-30)19-5-3-18(4-6-19)28-22-20-14-17(15-25)2-7-21(20)26-16-27-22/h2,7,14,16,18-19H,3-6,8-13H2,1H3,(H,26,27,28)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384625
PNG
(4-{[trans-4-(3- hydroxypyrrolidin-1- yl)cyclohexyl...)
Show SMILES OC1CCN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C19H23N5O/c20-10-13-1-6-18-17(9-13)19(22-12-21-18)23-14-2-4-15(5-3-14)24-8-7-16(25)11-24/h1,6,9,12,14-16,25H,2-5,7-8,11H2,(H,21,22,23)/t14-,15-,16?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384598
PNG
(4-({trans-4- [cyclopropyl(methyl) amino]cyclohexyl...)
Show SMILES CN(C1CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C19H23N5/c1-24(16-7-8-16)15-5-3-14(4-6-15)23-19-17-10-13(11-20)2-9-18(17)21-12-22-19/h2,9-10,12,14-16H,3-8H2,1H3,(H,21,22,23)/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384559
PNG
(6-bromo-7-fluoro-N- [trans-4-(morpholin-4- yl)cycl...)
Show SMILES Fc1cc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2cc1Br
Show InChI InChI=1S/C18H22BrFN4O/c19-15-9-14-17(10-16(15)20)21-11-22-18(14)23-12-1-3-13(4-2-12)24-5-7-25-8-6-24/h9-13H,1-8H2,(H,21,22,23)/t12-,13-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384556
PNG
(6-methoxy-N-[trans-4- (morpholin-4- yl)cyclohexyl]...)
Show SMILES COc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C19H26N4O2/c1-24-16-6-7-18-17(12-16)19(21-13-20-18)22-14-2-4-15(5-3-14)23-8-10-25-11-9-23/h6-7,12-15H,2-5,8-11H2,1H3,(H,20,21,22)/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384638
PNG
(4-({trans-4-[4- (methoxyacetyl)piperazin- 1- yl]cy...)
Show SMILES COCC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C22H28N6O2/c1-30-14-21(29)28-10-8-27(9-11-28)18-5-3-17(4-6-18)26-22-19-12-16(13-23)2-7-20(19)24-15-25-22/h2,7,12,15,17-18H,3-6,8-11,14H2,1H3,(H,24,25,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242731
PNG
(CHEMBL4089544 | US9932350, 2-14)
Show SMILES COc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1/C17H24N4O/c1-21(2)13-6-4-12(5-7-13)20-17-15-10-14(22-3)8-9-16(15)18-11-19-17/h8-13H,4-7H2,1-3H3,(H,18,19,20)/t12-,13-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384634
PNG
(4-({trans-4-[4-(2,2- difluoropropanoyl)piperazin- ...)
Show SMILES CC(F)(F)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C22H26F2N6O/c1-22(23,24)21(31)30-10-8-29(9-11-30)17-5-3-16(4-6-17)28-20-18-12-15(13-25)2-7-19(18)26-14-27-20/h2,7,12,14,16-17H,3-6,8-11H2,1H3,(H,26,27,28)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384588
PNG
(4-({trans-4-[(2- methoxyethyl)amino] cyclohexyl}am...)
Show SMILES COCCN[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C18H23N5O/c1-24-9-8-20-14-3-5-15(6-4-14)23-18-16-10-13(11-19)2-7-17(16)21-12-22-18/h2,7,10,12,14-15,20H,3-6,8-9H2,1H3,(H,21,22,23)/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384651
PNG
(4-[(trans-4-{4-[(2R)- tetrahydrofuran-2- ylcarbony...)
Show SMILES O=C([C@H]1CCCO1)N1CCN(CC1)N1CCC(CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C23H29N7O2/c24-15-17-3-4-20-19(14-17)22(26-16-25-20)27-18-5-7-29(8-6-18)30-11-9-28(10-12-30)23(31)21-2-1-13-32-21/h3-4,14,16,18,21H,1-2,5-13H2,(H,25,26,27)/t21-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242728
PNG
(CHEMBL4087971 | US9932350, 3-30)
Show SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1/C20H26N6/c1-25-8-10-26(11-9-25)17-5-3-16(4-6-17)24-20-18-12-15(13-21)2-7-19(18)22-14-23-20/h2,7,12,14,16-17H,3-6,8-11H2,1H3,(H,22,23,24)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384647
PNG
(4-({trans-4-[4- (fluoroacetyl)piperazin- 1- yl]cyc...)
Show SMILES FCC(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H25FN6O/c22-12-20(29)28-9-7-27(8-10-28)17-4-2-16(3-5-17)26-21-18-11-15(13-23)1-6-19(18)24-14-25-21/h1,6,11,14,16-17H,2-5,7-10,12H2,(H,24,25,26)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384602
PNG
(4-{[trans-4-(3-hydroxy- 3-methylpyrrolidin-1- yl)c...)
Show SMILES CC1(O)CCN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H25N5O/c1-20(26)8-9-25(12-20)16-5-3-15(4-6-16)24-19-17-10-14(11-21)2-7-18(17)22-13-23-19/h2,7,10,13,15-16,26H,3-6,8-9,12H2,1H3,(H,22,23,24)/t15-,16-,20?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384589
PNG
(4-{[trans-4- (cyclopropylamino)cyclo- hexyl]amino}...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)NC3CC3)c2c1
Show InChI InChI=1S/C18H21N5/c19-10-12-1-8-17-16(9-12)18(21-11-20-17)23-15-6-4-14(5-7-15)22-13-2-3-13/h1,8-9,11,13-15,22H,2-7H2,(H,20,21,23)/t14-,15-
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n/an/a 26n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384662
PNG
(4-{[(1S,2R,4S or 1R,2S,4R)-2-methyl-4- (morpholin-...)
Show SMILES CC1CC(CCC1Nc1ncnc2ccc(cc12)C#N)N1CCOCC1
Show InChI InChI=1S/C20H25N5O/c1-14-10-16(25-6-8-26-9-7-25)3-5-18(14)24-20-17-11-15(12-21)2-4-19(17)22-13-23-20/h2,4,11,13-14,16,18H,3,5-10H2,1H3,(H,22,23,24)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384622
PNG
(4-({trans-4-[(3R)-3- (propan-2-yl)morpholin- 4- yl...)
Show SMILES CC(C)[C@@H]1COCCN1[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C22H29N5O/c1-15(2)21-13-28-10-9-27(21)18-6-4-17(5-7-18)26-22-19-11-16(12-23)3-8-20(19)24-14-25-22/h3,8,11,14-15,17-18,21H,4-7,9-10,13H2,1-2H3,(H,24,25,26)/t17-,18-,21-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384548
PNG
(US9932350, 1-2 | trans-N-(6- bromoquinazolin-4- yl...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(Br)cc12
Show InChI InChI=1S/C14H17BrN4/c15-9-1-6-13-12(7-9)14(18-8-17-13)19-11-4-2-10(16)3-5-11/h1,6-8,10-11H,2-5,16H2,(H,17,18,19)/t10-,11-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384640
PNG
(4-({trans-4-[4- (difluoroacetyl)piperazin- 1- yl]c...)
Show SMILES FC(F)C(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H24F2N6O/c22-19(23)21(30)29-9-7-28(8-10-29)16-4-2-15(3-5-16)27-20-17-11-14(12-24)1-6-18(17)25-13-26-20/h1,6,11,13,15-16,19H,2-5,7-10H2,(H,25,26,27)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384627
PNG
(7-Fluoro-4-{[trans-4-(morpholin-4-yl)cyclohexyl]am...)
Show SMILES Fc1cc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2cc1C#N
Show InChI InChI=1S/C19H22FN5O/c20-17-10-18-16(9-13(17)11-21)19(23-12-22-18)24-14-1-3-15(4-2-14)25-5-7-26-8-6-25/h9-10,12,14-15H,1-8H2,(H,22,23,24)/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242702
PNG
(CHEMBL4082572 | US9932350, 1-1)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1/C15H17N5/c16-8-10-1-6-14-13(7-10)15(19-9-18-14)20-12-4-2-11(17)3-5-12/h1,6-7,9,11-12H,2-5,17H2,(H,18,19,20)/t11-,12-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384568
PNG
(4-({cis or trans-4-[(3R or S)-3- (trifluoromethyl)...)
Show SMILES FC(F)(F)C1CCCN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H24F3N5/c22-21(23,24)15-2-1-9-29(12-15)17-6-4-16(5-7-17)28-20-18-10-14(11-25)3-8-19(18)26-13-27-20/h3,8,10,13,15-17H,1-2,4-7,9,12H2,(H,26,27,28)/t15?,16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384580
PNG
(4-({trans-4-[(2S,6S or 2R,6R)-2,6- dimethylmorphol...)
Show SMILES CC1CN(CC(C)O1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H27N5O/c1-14-11-26(12-15(2)27-14)18-6-4-17(5-7-18)25-21-19-9-16(10-22)3-8-20(19)23-13-24-21/h3,8-9,13-15,17-18H,4-7,11-12H2,1-2H3,(H,23,24,25)/t14?,15?,17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384600
PNG
(4-({trans-4-[(3S)-3- hydroxypyrrolidin-1- yl]cyclo...)
Show SMILES O[C@H]1CCN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C19H23N5O/c20-10-13-1-6-18-17(9-13)19(22-12-21-18)23-14-2-4-15(5-3-14)24-8-7-16(25)11-24/h1,6,9,12,14-16,25H,2-5,7-8,11H2,(H,21,22,23)/t14-,15-,16-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242694
PNG
(CHEMBL4060699 | US9932350, 3-1)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC3)c2c1
Show InChI InChI=1/C18H21N5/c19-11-13-2-7-17-16(10-13)18(21-12-20-17)22-14-3-5-15(6-4-14)23-8-1-9-23/h2,7,10,12,14-15H,1,3-6,8-9H2,(H,20,21,22)/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384601
PNG
(4-{[trans-4-(3- fluoropiperidin-1- yl)cyclohexyl]a...)
Show SMILES FC1CCCN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H24FN5/c21-15-2-1-9-26(12-15)17-6-4-16(5-7-17)25-20-18-10-14(11-22)3-8-19(18)23-13-24-20/h3,8,10,13,15-17H,1-2,4-7,9,12H2,(H,23,24,25)/t15?,16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384549
PNG
(US9932350, 2-1)
Show SMILES Brc1ccc2ncnc(O[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C18H22BrN3O2/c19-13-1-6-17-16(11-13)18(21-12-20-17)24-15-4-2-14(3-5-15)22-7-9-23-10-8-22/h1,6,11-12,14-15H,2-5,7-10H2/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384603
PNG
(4-({trans-4-[3- (morpholin-4-yl)azetidin- 1- yl]cy...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CC(C3)N3CCOCC3)c2c1
Show InChI InChI=1S/C22H28N6O/c23-12-16-1-6-21-20(11-16)22(25-15-24-21)26-17-2-4-18(5-3-17)28-13-19(14-28)27-7-9-29-10-8-27/h1,6,11,15,17-19H,2-5,7-10,13-14H2,(H,24,25,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384654
PNG
(4-{[trans-4-(3- hydroxypyrrolidin-1-yl)- 1- methyl...)
Show SMILES C[C@@]1(CC[C@@H](CC1)N1CCC(O)C1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H25N5O/c1-20(7-4-15(5-8-20)25-9-6-16(26)12-25)24-19-17-10-14(11-21)2-3-18(17)22-13-23-19/h2-3,10,13,15-16,26H,4-9,12H2,1H3,(H,22,23,24)/t15-,16?,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384592
PNG
(4-{[trans-4-(4-oxa-7- azaspiro[2.5]oct-7- yl)cyclo...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOC4(CC4)C3)c2c1
Show InChI InChI=1S/C21H25N5O/c22-12-15-1-6-19-18(11-15)20(24-14-23-19)25-16-2-4-17(5-3-16)26-9-10-27-21(13-26)7-8-21/h1,6,11,14,16-17H,2-5,7-10,13H2,(H,23,24,25)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384594
PNG
(4-({trans-4-[(3S)-3- methylmorpholin-4- yl]cyclohe...)
Show SMILES C[C@H]1COCCN1[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H25N5O/c1-14-12-26-9-8-25(14)17-5-3-16(4-6-17)24-20-18-10-15(11-21)2-7-19(18)22-13-23-20/h2,7,10,13-14,16-17H,3-6,8-9,12H2,1H3,(H,22,23,24)/t14-,16-,17-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384606
PNG
(4-({trans-4-[(3R)-3- methoxypyrrolidin-1- yl]cyclo...)
Show SMILES CO[C@@H]1CCN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H25N5O/c1-26-17-8-9-25(12-17)16-5-3-15(4-6-16)24-20-18-10-14(11-21)2-7-19(18)22-13-23-20/h2,7,10,13,15-17H,3-6,8-9,12H2,1H3,(H,22,23,24)/t15-,16-,17-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384628
PNG
(5-methyl-4-{[trans-4- (morpholin-4- yl)cyclohexyl]...)
Show SMILES Cc1c(ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c12)C#N
Show InChI InChI=1S/C20H25N5O/c1-14-15(12-21)2-7-18-19(14)20(23-13-22-18)24-16-3-5-17(6-4-16)25-8-10-26-11-9-25/h2,7,13,16-17H,3-6,8-11H2,1H3,(H,22,23,24)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384565
PNG
(2-[(4-{[trans-4- (dimethylamino)cyclohexyl] amino}...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(OCC(N)=O)cc12
Show InChI InChI=1S/C18H25N5O2/c1-23(2)13-5-3-12(4-6-13)22-18-15-9-14(25-10-17(19)24)7-8-16(15)20-11-21-18/h7-9,11-13H,3-6,10H2,1-2H3,(H2,19,24)(H,20,21,22)/t12-,13-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384591
PNG
(4-{[trans-4-(hexahydro- 2H-pyrano[4,3-b]pyridin- 1...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCCC4COCCC34)c2c1
Show InChI InChI=1S/C23H29N5O/c24-13-16-3-8-21-20(12-16)23(26-15-25-21)27-18-4-6-19(7-5-18)28-10-1-2-17-14-29-11-9-22(17)28/h3,8,12,15,17-19,22H,1-2,4-7,9-11,14H2,(H,25,26,27)/t17?,18-,19-,22?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384566
PNG
(4-{[(1S,6R)-5- (morpholin-4- yl)bicyclo[4.1.0]hept...)
Show SMILES N#Cc1ccc2ncnc(NC3CCC([C@@H]4C[C@H]34)N3CCOCC3)c2c1
Show InChI InChI=1S/C20H23N5O/c21-11-13-1-2-17-16(9-13)20(23-12-22-17)24-18-3-4-19(15-10-14(15)18)25-5-7-26-8-6-25/h1-2,9,12,14-15,18-19H,3-8,10H2,(H,22,23,24)/t14-,15+,18?,19?/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384560
PNG
(7-fluoro-6-methoxy-N- [trans-4-(morpholin-4- yl)cy...)
Show SMILES COc1cc2c(N[C@H]3CC[C@@H](CC3)N3CCOCC3)ncnc2cc1F
Show InChI InChI=1S/C19H25FN4O2/c1-25-18-10-15-17(11-16(18)20)21-12-22-19(15)23-13-2-4-14(5-3-13)24-6-8-26-9-7-24/h10-14H,2-9H2,1H3,(H,21,22,23)/t13-,14-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384580
PNG
(4-({trans-4-[(2S,6S or 2R,6R)-2,6- dimethylmorphol...)
Show SMILES CC1CN(CC(C)O1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H27N5O/c1-14-11-26(12-15(2)27-14)18-6-4-17(5-7-18)25-21-19-9-16(10-22)3-8-20(19)23-13-24-21/h3,8-9,13-15,17-18H,4-7,11-12H2,1-2H3,(H,23,24,25)/t14?,15?,17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384611
PNG
(4-({trans-4-[(3R or 3S)- 3-(morpholin-4- ylmethyl)...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCCC(CN4CCOCC4)C3)c2c1
Show InChI InChI=1S/C25H34N6O/c26-15-19-3-8-24-23(14-19)25(28-18-27-24)29-21-4-6-22(7-5-21)31-9-1-2-20(17-31)16-30-10-12-32-13-11-30/h3,8,14,18,20-22H,1-2,4-7,9-13,16-17H2,(H,27,28,29)/t20?,21-,22-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384653
PNG
(4-{[trans-4-(4- fluoropiperidin-1-yl)-1- methylcyc...)
Show SMILES C[C@@]1(CC[C@@H](CC1)N1CCC(F)CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H26FN5/c1-21(8-4-17(5-9-21)27-10-6-16(22)7-11-27)26-20-18-12-15(13-23)2-3-19(18)24-14-25-20/h2-3,12,14,16-17H,4-11H2,1H3,(H,24,25,26)/t17-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384558
PNG
(N-[trans-4-(morpholin-4- yl)cyclohexyl]-6-(propan-...)
Show SMILES CC(C)Oc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C21H30N4O2/c1-15(2)27-18-7-8-20-19(13-18)21(23-14-22-20)24-16-3-5-17(6-4-16)25-9-11-26-12-10-25/h7-8,13-17H,3-6,9-12H2,1-2H3,(H,22,23,24)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384621
PNG
(4-{[trans-4-(2,2- dimethylmorpholin-4- yl)cyclohex...)
Show SMILES CC1(C)CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H27N5O/c1-21(2)13-26(9-10-27-21)17-6-4-16(5-7-17)25-20-18-11-15(12-22)3-8-19(18)23-14-24-20/h3,8,11,14,16-17H,4-7,9-10,13H2,1-2H3,(H,23,24,25)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384573
PNG
(4-{[trans-4-(2,3- dimethylmorpholin-4- yl)cyclohex...)
Show SMILES CC1OCCN([C@H]2CC[C@@H](CC2)Nc2ncnc3ccc(cc23)C#N)C1C
Show InChI InChI=1S/C21H27N5O/c1-14-15(2)27-10-9-26(14)18-6-4-17(5-7-18)25-21-19-11-16(12-22)3-8-20(19)23-13-24-21/h3,8,11,13-15,17-18H,4-7,9-10H2,1-2H3,(H,23,24,25)/t14?,15?,17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384652
PNG
(4-{[Trans-1-methyl-4-(morpholin-4-yl)cyclohexyl]am...)
Show SMILES CC1(CCC(CC1)N1CCOCC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H25N5O/c1-20(6-4-16(5-7-20)25-8-10-26-11-9-25)24-19-17-12-15(13-21)2-3-18(17)22-14-23-19/h2-3,12,14,16H,4-11H2,1H3,(H,22,23,24)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384557
PNG
(6-fluoro-N-[trans-4- (morpholin-4- yl)cyclohexyl]q...)
Show SMILES Fc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C18H23FN4O/c19-13-1-6-17-16(11-13)18(21-12-20-17)22-14-2-4-15(5-3-14)23-7-9-24-10-8-23/h1,6,11-12,14-15H,2-5,7-10H2,(H,20,21,22)/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384584
PNG
(4-({trans-4-[(1S,4S)-2- oxa-5- azabicyclo[2.2.1]he...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3C[C@@H]4C[C@H]3CO4)c2c1
Show InChI InChI=1S/C20H23N5O/c21-9-13-1-6-19-18(7-13)20(23-12-22-19)24-14-2-4-15(5-3-14)25-10-17-8-16(25)11-26-17/h1,6-7,12,14-17H,2-5,8,10-11H2,(H,22,23,24)/t14-,15-,16-,17-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384618
PNG
(4-({trans-4-[(2R or 2S)- 2- (trifluoromethyl)morph...)
Show SMILES FC(F)(F)C1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H22F3N5O/c21-20(22,23)18-11-28(7-8-29-18)15-4-2-14(3-5-15)27-19-16-9-13(10-24)1-6-17(16)25-12-26-19/h1,6,9,12,14-15,18H,2-5,7-8,11H2,(H,25,26,27)/t14-,15-,18?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384599
PNG
(4-{[trans-4-(3,3- difluoropiperidin-1- yl)cyclohex...)
Show SMILES FC1(F)CCCN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H23F2N5/c21-20(22)8-1-9-27(12-20)16-5-3-15(4-6-16)26-19-17-10-14(11-23)2-7-18(17)24-13-25-19/h2,7,10,13,15-16H,1,3-6,8-9,12H2,(H,24,25,26)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384605
PNG
(4-{[trans-4-(hexahydro- 4H-furo[3,2-b]pyrrol-4- yl...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC4OCCC34)c2c1
Show InChI InChI=1S/C21H25N5O/c22-12-14-1-6-18-17(11-14)21(24-13-23-18)25-15-2-4-16(5-3-15)26-9-7-20-19(26)8-10-27-20/h1,6,11,13,15-16,19-20H,2-5,7-10H2,(H,23,24,25)/t15-,16-,19?,20?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384618
PNG
(4-({trans-4-[(2R or 2S)- 2- (trifluoromethyl)morph...)
Show SMILES FC(F)(F)C1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C20H22F3N5O/c21-20(22,23)18-11-28(7-8-29-18)15-4-2-14(3-5-15)27-19-16-9-13(10-24)1-6-17(16)25-12-26-19/h1,6,9,12,14-15,18H,2-5,7-8,11H2,(H,25,26,27)/t14-,15-,18?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242729
PNG
(CHEMBL4090409 | US9932350, 2-4)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2cc(F)c(F)cc12
Show InChI InChI=1/C16H20F2N4/c1-22(2)11-5-3-10(4-6-11)21-16-12-7-13(17)14(18)8-15(12)19-9-20-16/h7-11H,3-6H2,1-2H3,(H,19,20,21)/t10-,11-
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US Patent
n/an/a 303n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384569
PNG
(4-({cis or trans-4-[(3R or S)-3- (trifluoromethyl)...)
Show SMILES FC(F)(F)C1CCCN(C1)C1CCC(CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H24F3N5/c22-21(23,24)15-2-1-9-29(12-15)17-6-4-16(5-7-17)28-20-18-10-14(11-25)3-8-19(18)26-13-27-20/h3,8,10,13,15-17H,1-2,4-7,9,12H2,(H,26,27,28)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384587
PNG
(4-({trans-4-[(2,2,2- trifluoroethyl)amino]cyclo- h...)
Show SMILES FC(F)(F)CN[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C17H18F3N5/c18-17(19,20)9-22-12-2-4-13(5-3-12)25-16-14-7-11(8-21)1-6-15(14)23-10-24-16/h1,6-7,10,12-13,22H,2-5,9H2,(H,23,24,25)/t12-,13-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384626
PNG
(4-[(4-{[Trans-4-(dimethylamino)cyclohexyl]amino}qu...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(OCCCC(N)=O)cc12
Show InChI InChI=1S/C20H29N5O2/c1-25(2)15-7-5-14(6-8-15)24-20-17-12-16(27-11-3-4-19(21)26)9-10-18(17)22-13-23-20/h9-10,12-15H,3-8,11H2,1-2H3,(H2,21,26)(H,22,23,24)/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384620
PNG
(4-({trans-4-[(1R,5S)-8- oxa-3- azabicylco[3.2.1]oc...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3C[C@@H]4CC[C@H](C3)O4)c2c1
Show InChI InChI=1S/C21H25N5O/c22-10-14-1-8-20-19(9-14)21(24-13-23-20)25-15-2-4-16(5-3-15)26-11-17-6-7-18(12-26)27-17/h1,8-9,13,15-18H,2-7,11-12H2,(H,23,24,25)/t15-,16-,17-,18?/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384564
PNG
(4-[(4-{[trans-4- (dimethylamino)cyclohexyl] amino}...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(OCCCC#N)cc12
Show InChI InChI=1S/C20H27N5O/c1-25(2)16-7-5-15(6-8-16)24-20-18-13-17(26-12-4-3-11-21)9-10-19(18)22-14-23-20/h9-10,13-16H,3-8,12H2,1-2H3,(H,22,23,24)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384572
PNG
(4-{[cis-4-(azetidin-1- yl)cyclohexyl]amino} quinaz...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@H](CC3)N3CCC3)c2c1
Show InChI InChI=1S/C18H21N5/c19-11-13-2-7-17-16(10-13)18(21-12-20-17)22-14-3-5-15(6-4-14)23-8-1-9-23/h2,7,10,12,14-15H,1,3-6,8-9H2,(H,20,21,22)/t14-,15+
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US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384617
PNG
(4-{[trans-4-(3-oxa-8- azabicyclo[3.2.1]oct-8- yl)c...)
Show SMILES N#Cc1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3C4CCC3COC4)c2c1
Show InChI InChI=1S/C21H25N5O/c22-10-14-1-8-20-19(9-14)21(24-13-23-20)25-15-2-4-16(5-3-15)26-17-6-7-18(26)12-27-11-17/h1,8-9,13,15-18H,2-7,11-12H2,(H,23,24,25)/t15-,16-,17?,18?
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n/an/a 872n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384569
PNG
(4-({cis or trans-4-[(3R or S)-3- (trifluoromethyl)...)
Show SMILES FC(F)(F)C1CCCN(C1)C1CCC(CC1)Nc1ncnc2ccc(cc12)C#N
Show InChI InChI=1S/C21H24F3N5/c22-21(23,24)15-2-1-9-29(12-15)17-6-4-16(5-7-17)28-20-18-10-14(11-25)3-8-19(18)26-13-27-20/h3,8,10,13,15-17H,1-2,4-7,9,12H2,(H,26,27,28)
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n/an/a 908n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM384574
PNG
(4-{[cis-4-(2,3- dimethylmorpholin-4- yl)cyclohexyl...)
Show SMILES CC1OCCN([C@@H]2CC[C@@H](CC2)Nc2ncnc3ccc(cc23)C#N)C1C
Show InChI InChI=1S/C21H27N5O/c1-14-15(2)27-10-9-26(14)18-6-4-17(5-7-18)25-21-19-11-16(12-22)3-8-20(19)23-13-24-21/h3,8,11,13-15,17-18H,4-7,9-10H2,1-2H3,(H,23,24,25)/t14?,15?,17-,18+
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n/an/a 2.55E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM50242705
PNG
(CHEMBL4091329 | US9932350, 2-3)
Show SMILES COc1cc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2cc1OC
Show InChI InChI=1/C18H26N4O2/c1-22(2)13-7-5-12(6-8-13)21-18-14-9-16(23-3)17(24-4)10-15(14)19-11-20-18/h9-13H,5-8H2,1-4H3,(H,19,20,21)/t12-,13-
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US Patent
n/an/a 7.42E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9932350 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%