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Patent code US9938222

Compile Data Set for Download or QSAR
Found 129 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384320
PNG
(Trans-2-(((3′-chloro-3-fluoro-5′-isopr...)
Show SMILES CC(C)Oc1cc(Cl)cc(c1)-c1ccc(OC[C@H]2C[C@@H]2C(O)=O)c(F)c1
Show InChI InChI=1S/C20H20ClFO4/c1-11(2)26-16-6-13(5-15(21)9-16)12-3-4-19(18(22)8-12)25-10-14-7-17(14)20(23)24/h3-6,8-9,11,14,17H,7,10H2,1-2H3,(H,23,24)/t14-,17+/m1/s1
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n/an/an/an/a 830n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384354
PNG
(Trans-2-(((3′-fluoro-5′-phenoxy-[1,1&#...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(F)cc(Oc2ccccc2)c1
Show InChI InChI=1S/C23H19FO4/c24-18-10-16(11-21(13-18)28-20-4-2-1-3-5-20)15-6-8-19(9-7-15)27-14-17-12-22(17)23(25)26/h1-11,13,17,22H,12,14H2,(H,25,26)
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n/an/an/an/a 660n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385612
PNG
(Trans-2-(((2′-fluoro-5′-phenoxy-[1,1&#...)
Show SMILES OC(=O)C1CC1COCc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1F
Show InChI InChI=1S/C24H21FO4/c25-23-11-10-20(29-19-4-2-1-3-5-19)13-21(23)17-8-6-16(7-9-17)14-28-15-18-12-22(18)24(26)27/h1-11,13,18,22H,12,14-15H2,(H,26,27)
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Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386918
PNG
(US9938222, Example 47)
Show SMILES CC(C)Oc1cc(cc(c1)C(F)(F)F)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H21F3O4/c1-12(2)28-18-8-14(7-16(10-18)21(22,23)24)13-3-5-17(6-4-13)27-11-15-9-19(15)20(25)26/h3-8,10,12,15,19H,9,11H2,1-2H3,(H,25,26)
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n/an/an/an/a 2.04E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386925
PNG
(US9938222, Example 54)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(OC(F)(F)F)ccc1Cl
Show InChI InChI=1S/C18H14ClF3O4/c19-16-6-5-13(26-18(20,21)22)8-14(16)10-1-3-12(4-2-10)25-9-11-7-15(11)17(23)24/h1-6,8,11,15H,7,9H2,(H,23,24)
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n/an/an/an/a 500n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386927
PNG
(US9938222, Example 56 | US9938222, Example 57 | US...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(F)ccc1Oc1ccccc1
Show InChI InChI=1S/C23H19FO4/c24-17-8-11-22(28-19-4-2-1-3-5-19)20(13-17)15-6-9-18(10-7-15)27-14-16-12-21(16)23(25)26/h1-11,13,16,21H,12,14H2,(H,25,26)
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n/an/an/an/a 110n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386953
PNG
(Trans-2-((4-(1-(4-chlorophenyl)-3-methyl-1H-pyrazo...)
Show SMILES Cc1cc(-c2ccc(OCC3CC3C(O)=O)cc2)n(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C21H19ClN2O3/c1-13-10-20(24(23-13)17-6-4-16(22)5-7-17)14-2-8-18(9-3-14)27-12-15-11-19(15)21(25)26/h2-10,15,19H,11-12H2,1H3,(H,25,26)
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n/an/an/an/a 4.96E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386955
PNG
(Trans-2-((4-(1-benzyl-3-methyl-1H-pyrazol-4-yl)phe...)
Show SMILES Cc1nn(Cc2ccccc2)cc1-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C22H22N2O3/c1-15-21(13-24(23-15)12-16-5-3-2-4-6-16)17-7-9-19(10-8-17)27-14-18-11-20(18)22(25)26/h2-10,13,18,20H,11-12,14H2,1H3,(H,25,26)
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n/an/an/an/a 4.31E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386961
PNG
(Trans-2-(((2′-fluoro-5′-isopropoxy-3-(...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OCC2CC2C(O)=O)c(CC=O)c1
Show InChI InChI=1S/C22H23FO5/c1-13(2)28-17-4-5-20(23)18(11-17)14-3-6-21(15(9-14)7-8-24)27-12-16-10-19(16)22(25)26/h3-6,8-9,11,13,16,19H,7,10,12H2,1-2H3,(H,25,26)
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n/an/an/an/a 930n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386964
PNG
(Trans-2-(((5′-((R)-sec-butoxy)-2′-fluo...)
Show SMILES CC[C@@H](C)Oc1ccc(F)c(c1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H23FO4/c1-3-13(2)26-17-8-9-20(22)18(11-17)14-4-6-16(7-5-14)25-12-15-10-19(15)21(23)24/h4-9,11,13,15,19H,3,10,12H2,1-2H3,(H,23,24)/t13-,15?,19?/m1/s1
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n/an/an/an/a 300n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386982
PNG
(Trans-2-((4-(2-chloro-5-(3-fluorophenoxy)pyridin-3...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(Oc2cccc(F)c2)cnc1Cl
Show InChI InChI=1S/C22H17ClFNO4/c23-21-19(10-18(11-25-21)29-17-3-1-2-15(24)9-17)13-4-6-16(7-5-13)28-12-14-8-20(14)22(26)27/h1-7,9-11,14,20H,8,12H2,(H,26,27)
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n/an/an/an/a 190n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386993
PNG
(US9938222, Example 122)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(cnc1Cl)C(F)(F)F
Show InChI InChI=1S/C17H13ClF3NO3/c18-15-13(6-11(7-22-15)17(19,20)21)9-1-3-12(4-2-9)25-8-10-5-14(10)16(23)24/h1-4,6-7,10,14H,5,8H2,(H,23,24)
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n/an/an/an/a 1.35E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386995
PNG
(US9938222, Example 124)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(Cl)cc(c1)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3O3/c19-14-6-11(5-13(8-14)18(20,21)22)10-1-3-15(4-2-10)25-9-12-7-16(12)17(23)24/h1-6,8,12,16H,7,9H2,(H,23,24)
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n/an/an/an/a 2.44E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386996
PNG
(US9938222, Example 125)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1ccccc1-c1ccccc1
Show InChI InChI=1S/C23H20O3/c24-23(25)22-14-18(22)15-26-19-12-10-17(11-13-19)21-9-5-4-8-20(21)16-6-2-1-3-7-16/h1-13,18,22H,14-15H2,(H,24,25)
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n/an/an/an/a 6.84E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM387003
PNG
(US9938222, Example 132)
Show SMILES CC(C)Oc1cc(Cl)cc(c1)-c1ccc(CCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H23ClO3/c1-13(2)25-19-10-17(9-18(22)12-19)15-6-3-14(4-7-15)5-8-16-11-20(16)21(23)24/h3-4,6-7,9-10,12-13,16,20H,5,8,11H2,1-2H3,(H,23,24)
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n/an/an/an/a 2.44E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384313
PNG
((1R,2R)-2-(((2′,3-Difluoro-5′-phenoxy-...)
Show SMILES OC(=O)[C@@H]1C[C@H]1COc1ccc(cc1F)-c1cc(Oc2ccccc2)ccc1F
Show InChI InChI=1S/C23H18F2O4/c24-20-8-7-17(29-16-4-2-1-3-5-16)12-18(20)14-6-9-22(21(25)11-14)28-13-15-10-19(15)23(26)27/h1-9,11-12,15,19H,10,13H2,(H,26,27)/t15-,19+/m0/s1
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n/an/an/an/a 80n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384305
PNG
((Trans)-(+/−)-2-(((2′,3-difluoro-5R...)
Show SMILES OC(=O)[C@H]1C[C@@H]1COc1ccc(cc1F)-c1cc(Oc2ccccc2)ccc1F
Show InChI InChI=1S/C23H18F2O4/c24-20-8-7-17(29-16-4-2-1-3-5-16)12-18(20)14-6-9-22(21(25)11-14)28-13-15-10-19(15)23(26)27/h1-9,11-12,15,19H,10,13H2,(H,26,27)/t15-,19+/m1/s1
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n/an/an/an/a 160n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384338
PNG
((1R,2S)-2-(2-(2′-Fluoro-5′-isopropoxy-...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(CC[C@H]2C[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C21H23FO3/c1-13(2)25-17-9-10-20(22)18(12-17)15-6-3-14(4-7-15)5-8-16-11-19(16)21(23)24/h3-4,6-7,9-10,12-13,16,19H,5,8,11H2,1-2H3,(H,23,24)/t16-,19+/m0/s1
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n/an/an/an/a 420n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385605
PNG
(Trans-2-(((2′-fluoro-5′-isopropoxy-[1,...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(COCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H23FO4/c1-13(2)26-17-7-8-20(22)18(10-17)15-5-3-14(4-6-15)11-25-12-16-9-19(16)21(23)24/h3-8,10,13,16,19H,9,11-12H2,1-2H3,(H,23,24)
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n/an/an/an/a 440n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385620
PNG
(Trans-2-(2-(2′-fluoro-5′-isopropoxy-[1...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(CCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H23FO3/c1-13(2)25-17-9-10-20(22)18(12-17)15-6-3-14(4-7-15)5-8-16-11-19(16)21(23)24/h3-4,6-7,9-10,12-13,16,19H,5,8,11H2,1-2H3,(H,23,24)
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n/an/an/an/a 320n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386912
PNG
(Trans-2-(2-(2′-fluoro-5′-isopropoxy-[1...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(CC[C@H]2C[C@]2(C)C(O)=O)cc1
Show InChI InChI=1S/C22H25FO3/c1-14(2)26-18-10-11-20(23)19(12-18)16-7-4-15(5-8-16)6-9-17-13-22(17,3)21(24)25/h4-5,7-8,10-12,14,17H,6,9,13H2,1-3H3,(H,24,25)/t17-,22-/m0/s1
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n/an/an/an/a 860n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386922
PNG
(US9938222, Example 51 | US9938222, Example 52 | US...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H14F4O4/c19-16-6-5-13(26-18(20,21)22)8-14(16)10-1-3-12(4-2-10)25-9-11-7-15(11)17(23)24/h1-6,8,11,15H,7,9H2,(H,23,24)
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n/an/an/an/a 330n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386937
PNG
(US9938222, Example 66)
Show SMILES CC(C)Oc1cc(F)c(F)c(c1)-c1ccc(OC[C@@H]2C[C@H]2C(O)=O)c(F)c1
Show InChI InChI=1S/C20H19F3O4/c1-10(2)27-13-7-14(19(23)17(22)8-13)11-3-4-18(16(21)6-11)26-9-12-5-15(12)20(24)25/h3-4,6-8,10,12,15H,5,9H2,1-2H3,(H,24,25)/t12-,15+/m0/s1
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US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386944
PNG
(US9938222, Example 73)
Show SMILES CC(C)Oc1cccc(c1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C20H22O4/c1-13(2)24-18-5-3-4-15(10-18)14-6-8-17(9-7-14)23-12-16-11-19(16)20(21)22/h3-10,13,16,19H,11-12H2,1-2H3,(H,21,22)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386947
PNG
(US9938222, Example 76)
Show SMILES OC(=O)C1CC1CCc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1F
Show InChI InChI=1S/C24H21FO3/c25-23-13-12-20(28-19-4-2-1-3-5-19)15-21(23)17-9-6-16(7-10-17)8-11-18-14-22(18)24(26)27/h1-7,9-10,12-13,15,18,22H,8,11,14H2,(H,26,27)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386962
PNG
(Trans-2-(((5′-(3,4-difluorophenoxy)-2′...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(Oc2ccc(F)c(F)c2)ccc1F
Show InChI InChI=1S/C23H17F3O4/c24-20-7-5-16(30-17-6-8-21(25)22(26)11-17)10-18(20)13-1-3-15(4-2-13)29-12-14-9-19(14)23(27)28/h1-8,10-11,14,19H,9,12H2,(H,27,28)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386966
PNG
(US9938222, Example 95)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(OCC2CC2)ccc1F
Show InChI InChI=1S/C21H21FO4/c22-20-8-7-17(25-11-13-1-2-13)10-18(20)14-3-5-16(6-4-14)26-12-15-9-19(15)21(23)24/h3-8,10,13,15,19H,1-2,9,11-12H2,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386971
PNG
(US9938222, Example 100 | US9938222, Example 101 | ...)
Show SMILES Cc1ccc(Oc2ccc(F)c(c2)-c2ccc(OCC3CC3C(O)=O)c(F)c2)cc1F
Show InChI InChI=1S/C24H19F3O4/c1-13-2-4-17(11-21(13)26)31-16-5-6-20(25)18(10-16)14-3-7-23(22(27)9-14)30-12-15-8-19(15)24(28)29/h2-7,9-11,15,19H,8,12H2,1H3,(H,28,29)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386975
PNG
(US9938222, Example 104)
Show SMILES OC(=O)C1CC1COc1ccc(cc1F)-c1cc(Oc2cccc(F)c2)cc(F)c1F
Show InChI InChI=1S/C23H16F4O4/c24-14-2-1-3-15(8-14)31-16-9-17(22(27)20(26)10-16)12-4-5-21(19(25)7-12)30-11-13-6-18(13)23(28)29/h1-5,7-10,13,18H,6,11H2,(H,28,29)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386976
PNG
(US9938222, Example 105)
Show SMILES OC(=O)[C@H]1C[C@@H]1COc1ccc(cc1F)-c1cc(Oc2cccc(F)c2)cc(F)c1F
Show InChI InChI=1S/C23H16F4O4/c24-14-2-1-3-15(8-14)31-16-9-17(22(27)20(26)10-16)12-4-5-21(19(25)7-12)30-11-13-6-18(13)23(28)29/h1-5,7-10,13,18H,6,11H2,(H,28,29)/t13-,18+/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386983
PNG
(US9938222, Example 112)
Show SMILES OC(=O)[C@@H]1CC1COc1ccc(cc1)-c1cc(Oc2cccc(F)c2)cnc1Cl
Show InChI InChI=1S/C22H17ClFNO4/c23-21-19(10-18(11-25-21)29-17-3-1-2-15(24)9-17)13-4-6-16(7-5-13)28-12-14-8-20(14)22(26)27/h1-7,9-11,14,20H,8,12H2,(H,26,27)/t14?,20-/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386985
PNG
(Trans-2-(((2′-fluoro-5′-((6-methylpyri...)
Show SMILES Cc1ccc(Oc2ccc(F)c(c2)-c2ccc(OCC3CC3C(O)=O)cc2)cn1
Show InChI InChI=1S/C23H20FNO4/c1-14-2-5-19(12-25-14)29-18-8-9-22(24)20(11-18)15-3-6-17(7-4-15)28-13-16-10-21(16)23(26)27/h2-9,11-12,16,21H,10,13H2,1H3,(H,26,27)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386990
PNG
(US9938222, Example 119)
Show SMILES CC(C)Oc1ccc(Cl)c(c1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C20H21ClO4/c1-12(2)25-16-7-8-19(21)17(10-16)13-3-5-15(6-4-13)24-11-14-9-18(14)20(22)23/h3-8,10,12,14,18H,9,11H2,1-2H3,(H,22,23)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384301
PNG
((1R,2S)-2-(((2′-Fluoro-5′-isopropoxy-[...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OC[C@H]2C[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C20H21FO4/c1-12(2)25-16-7-8-19(21)17(10-16)13-3-5-15(6-4-13)24-11-14-9-18(14)20(22)23/h3-8,10,12,14,18H,9,11H2,1-2H3,(H,22,23)/t14-,18-/m1/s1
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US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385695
PNG
((1S,2S)-2-(2-(2′-fluoro-5′-isopropoxy-...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(CC[C@H]2C[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C21H23FO3/c1-13(2)25-17-9-10-20(22)18(12-17)15-6-3-14(4-7-15)5-8-16-11-19(16)21(23)24/h3-4,6-7,9-10,12-13,16,19H,5,8,11H2,1-2H3,(H,23,24)/t16-,19-/m0/s1
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US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385825
PNG
(Cis-2-fluoro-2-(2-(2′-fluoro-5′-isopro...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(CC[C@]2(F)C[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C21H22F2O3/c1-13(2)26-16-7-8-19(22)17(11-16)15-5-3-14(4-6-15)9-10-21(23)12-18(21)20(24)25/h3-8,11,13,18H,9-10,12H2,1-2H3,(H,24,25)/t18-,21-/m0/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386916
PNG
(US9938222, Example 45)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OCC2CC2C(O)=O)c(Cl)c1
Show InChI InChI=1S/C20H20ClFO4/c1-11(2)26-14-4-5-18(22)15(9-14)12-3-6-19(17(21)8-12)25-10-13-7-16(13)20(23)24/h3-6,8-9,11,13,16H,7,10H2,1-2H3,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386930
PNG
(US9938222, Example 59)
Show SMILES COc1ccc(F)cc1-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C18H17FO4/c1-22-17-7-4-13(19)9-15(17)11-2-5-14(6-3-11)23-10-12-8-16(12)18(20)21/h2-7,9,12,16H,8,10H2,1H3,(H,20,21)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386933
PNG
(US9938222, Example 62)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OCC2CC2C(O)=O)c(F)c1
Show InChI InChI=1S/C20H20F2O4/c1-11(2)26-14-4-5-17(21)15(9-14)12-3-6-19(18(22)8-12)25-10-13-7-16(13)20(23)24/h3-6,8-9,11,13,16H,7,10H2,1-2H3,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386938
PNG
(US9938222, Example 67)
Show SMILES CC(C)Oc1cc(F)c(F)c(c1)-c1ccc(OC[C@H]2C[C@@H]2C(O)=O)c(F)c1
Show InChI InChI=1S/C20H19F3O4/c1-10(2)27-13-7-14(19(23)17(22)8-13)11-3-4-18(16(21)6-11)26-9-12-5-15(12)20(24)25/h3-4,6-8,10,12,15H,5,9H2,1-2H3,(H,24,25)/t12-,15+/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386940
PNG
(US9938222, Example 69)
Show SMILES CC(C)Sc1ncc(cc1-c1ccc(OCC2CC2C(O)=O)cc1)C(F)(F)F
Show InChI InChI=1S/C20H20F3NO3S/c1-11(2)28-18-16(8-14(9-24-18)20(21,22)23)12-3-5-15(6-4-12)27-10-13-7-17(13)19(25)26/h3-6,8-9,11,13,17H,7,10H2,1-2H3,(H,25,26)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386942
PNG
(US9938222, Example 71)
Show SMILES OCc1ccc(OC(F)(F)F)cc1-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C19H17F3O5/c20-19(21,22)27-15-6-3-12(9-23)16(8-15)11-1-4-14(5-2-11)26-10-13-7-17(13)18(24)25/h1-6,8,13,17,23H,7,9-10H2,(H,24,25)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386943
PNG
(US9938222, Example 72)
Show SMILES CC(C)COc1cc(F)cc(c1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H23FO4/c1-13(2)11-25-19-8-15(7-17(22)10-19)14-3-5-18(6-4-14)26-12-16-9-20(16)21(23)24/h3-8,10,13,16,20H,9,11-12H2,1-2H3,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386950
PNG
(US9938222, Example 79)
Show SMILES COc1ccc(OC(F)(F)F)cc1-c1ccc(CCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C20H19F3O4/c1-26-18-9-8-15(27-20(21,22)23)11-16(18)13-5-2-12(3-6-13)4-7-14-10-17(14)19(24)25/h2-3,5-6,8-9,11,14,17H,4,7,10H2,1H3,(H,24,25)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386968
PNG
(US9938222, Example 97)
Show SMILES OC(=O)[C@@H]1CC1COc1ccc(cc1F)-c1cc(Oc2cccc(F)c2)ccc1F
Show InChI InChI=1S/C23H17F3O4/c24-15-2-1-3-16(10-15)30-17-5-6-20(25)18(11-17)13-4-7-22(21(26)9-13)29-12-14-8-19(14)23(27)28/h1-7,9-11,14,19H,8,12H2,(H,27,28)/t14?,19-/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386969
PNG
(US9938222, Example 98)
Show SMILES OC(=O)[C@H]1CC1COc1ccc(cc1F)-c1cc(Oc2cccc(F)c2)ccc1F
Show InChI InChI=1S/C23H17F3O4/c24-15-2-1-3-16(10-15)30-17-5-6-20(25)18(11-17)13-4-7-22(21(26)9-13)29-12-14-8-19(14)23(27)28/h1-7,9-11,14,19H,8,12H2,(H,27,28)/t14?,19-/m0/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386970
PNG
(Trans-2-(((2′-fluoro-5′-(3-fluoropheno...)
Show SMILES COc1cc(ccc1OCC1CC1C(O)=O)-c1cc(Oc2cccc(F)c2)ccc1F
Show InChI InChI=1S/C24H20F2O5/c1-29-23-10-14(5-8-22(23)30-13-15-9-20(15)24(27)28)19-12-18(6-7-21(19)26)31-17-4-2-3-16(25)11-17/h2-8,10-12,15,20H,9,13H2,1H3,(H,27,28)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386987
PNG
(US9938222, Example 116)
Show SMILES Cc1ccc(Oc2ccc(F)c(c2)-c2ccc(OCC3C[C@@H]3C(O)=O)cc2)cn1
Show InChI InChI=1S/C23H20FNO4/c1-14-2-5-19(12-25-14)29-18-8-9-22(24)20(11-18)15-3-6-17(7-4-15)28-13-16-10-21(16)23(26)27/h2-9,11-12,16,21H,10,13H2,1H3,(H,26,27)/t16?,21-/m0/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384340
PNG
((1S,2R)-2-(2-(2′-Fluoro-5′-isopropoxy-...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(CC[C@@H]2C[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C21H23FO3/c1-13(2)25-17-9-10-20(22)18(12-17)15-6-3-14(4-7-15)5-8-16-11-19(16)21(23)24/h3-4,6-7,9-10,12-13,16,19H,5,8,11H2,1-2H3,(H,23,24)/t16-,19+/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386931
PNG
(US9938222, Example 60)
Show SMILES CC(C)Oc1cc(F)cc(c1)-c1ccc(OCC2CC2C(O)=O)cc1F
Show InChI InChI=1S/C20H20F2O4/c1-11(2)26-16-6-12(5-14(21)8-16)17-4-3-15(9-19(17)22)25-10-13-7-18(13)20(23)24/h3-6,8-9,11,13,18H,7,10H2,1-2H3,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386945
PNG
(US9938222, Example 74)
Show SMILES OCc1cc(OC(F)(F)F)cc(c1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C19H17F3O5/c20-19(21,22)27-16-6-11(9-23)5-13(7-16)12-1-3-15(4-2-12)26-10-14-8-17(14)18(24)25/h1-7,14,17,23H,8-10H2,(H,24,25)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386948
PNG
(US9938222, Example 77)
Show SMILES OCc1cc(Cl)cc(c1)-c1ccc(CCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C19H19ClO3/c20-17-8-13(11-21)7-16(9-17)14-4-1-12(2-5-14)3-6-15-10-18(15)19(22)23/h1-2,4-5,7-9,15,18,21H,3,6,10-11H2,(H,22,23)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386956
PNG
(Trans-2-((4-(1-(4-chlorobenzyl)-3-methyl-1H-pyrazo...)
Show SMILES Cc1nn(Cc2ccc(Cl)cc2)cc1-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C22H21ClN2O3/c1-14-21(12-25(24-14)11-15-2-6-18(23)7-3-15)16-4-8-19(9-5-16)28-13-17-10-20(17)22(26)27/h2-9,12,17,20H,10-11,13H2,1H3,(H,26,27)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386958
PNG
(Trans-2-(((2′-fluoro-3-formyl-5′-isopr...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OCC2CC2C(O)=O)c(C=O)c1
Show InChI InChI=1S/C21H21FO5/c1-12(2)27-16-4-5-19(22)17(9-16)13-3-6-20(14(7-13)10-23)26-11-15-8-18(15)21(24)25/h3-7,9-10,12,15,18H,8,11H2,1-2H3,(H,24,25)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386971
PNG
(US9938222, Example 100 | US9938222, Example 101 | ...)
Show SMILES Cc1ccc(Oc2ccc(F)c(c2)-c2ccc(OCC3CC3C(O)=O)c(F)c2)cc1F
Show InChI InChI=1S/C24H19F3O4/c1-13-2-4-17(11-21(13)26)31-16-5-6-20(25)18(10-16)14-3-7-23(22(27)9-14)30-12-15-8-19(15)24(28)29/h2-7,9-11,15,19H,8,12H2,1H3,(H,28,29)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386974
PNG
(US9938222, Example 103)
Show SMILES Cc1ccc(Oc2ccc(F)c(c2)-c2ccc(OCC3CC3C(O)=O)c(F)c2)cn1
Show InChI InChI=1S/C23H19F2NO4/c1-13-2-4-17(11-26-13)30-16-5-6-20(24)18(10-16)14-3-7-22(21(25)9-14)29-12-15-8-19(15)23(27)28/h2-7,9-11,15,19H,8,12H2,1H3,(H,27,28)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386978
PNG
(US9938222, Example 107 | US9938222, Example 108 | ...)
Show SMILES Cc1ccc(Oc2cc(F)c(F)c(c2)-c2ccc(OCC3CC3C(O)=O)c(F)c2)cc1F
Show InChI InChI=1S/C24H18F4O4/c1-12-2-4-15(9-19(12)25)32-16-8-17(23(28)21(27)10-16)13-3-5-22(20(26)7-13)31-11-14-6-18(14)24(29)30/h2-5,7-10,14,18H,6,11H2,1H3,(H,29,30)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386978
PNG
(US9938222, Example 107 | US9938222, Example 108 | ...)
Show SMILES Cc1ccc(Oc2cc(F)c(F)c(c2)-c2ccc(OCC3CC3C(O)=O)c(F)c2)cc1F
Show InChI InChI=1S/C24H18F4O4/c1-12-2-4-15(9-19(12)25)32-16-8-17(23(28)21(27)10-16)13-3-5-22(20(26)7-13)31-11-14-6-18(14)24(29)30/h2-5,7-10,14,18H,6,11H2,1H3,(H,29,30)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386986
PNG
(US9938222, Example 115)
Show SMILES Cc1ccc(Oc2ccc(F)c(c2)-c2ccc(OCC3C[C@H]3C(O)=O)cc2)cn1
Show InChI InChI=1S/C23H20FNO4/c1-14-2-5-19(12-25-14)29-18-8-9-22(24)20(11-18)15-3-6-17(7-4-15)28-13-16-10-21(16)23(26)27/h2-9,11-12,16,21H,10,13H2,1H3,(H,26,27)/t16?,21-/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386989
PNG
(US9938222, Example 118)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cccc(c1)C(=O)c1ccccc1
Show InChI InChI=1S/C24H20O4/c25-23(17-5-2-1-3-6-17)19-8-4-7-18(13-19)16-9-11-21(12-10-16)28-15-20-14-22(20)24(26)27/h1-13,20,22H,14-15H2,(H,26,27)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM387000
PNG
(US9938222, Example 129)
Show SMILES OC(=O)C1CC1CCc1ccc(cc1)-c1cccc(c1)-n1cccc1
Show InChI InChI=1S/C22H21NO2/c24-22(25)21-15-19(21)11-8-16-6-9-17(10-7-16)18-4-3-5-20(14-18)23-12-1-2-13-23/h1-7,9-10,12-14,19,21H,8,11,15H2,(H,24,25)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM387001
PNG
(US9938222, Example 130)
Show SMILES OCC(=O)c1cccc(c1)-c1ccc(CCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C20H20O4/c21-12-19(22)17-3-1-2-15(10-17)14-7-4-13(5-8-14)6-9-16-11-18(16)20(23)24/h1-5,7-8,10,16,18,21H,6,9,11-12H2,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384291
PNG
((METHOD A) | US9938222, Example 2)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OC[C@H]2C[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C20H21FO4/c1-12(2)25-16-7-8-19(21)17(10-16)13-3-5-15(6-4-13)24-11-14-9-18(14)20(22)23/h3-8,10,12,14,18H,9,11H2,1-2H3,(H,22,23)/t14-,18+/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384292
PNG
((METHOD A) | US9938222, Example 3)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OC[C@@H]2C[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C20H21FO4/c1-12(2)25-16-7-8-19(21)17(10-16)13-3-5-15(6-4-13)24-11-14-9-18(14)20(22)23/h3-8,10,12,14,18H,9,11H2,1-2H3,(H,22,23)/t14-,18+/m0/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384300
PNG
((1R,2S)-Methyl 2-((4-bromophenoxy)methyl)cycloprop...)
Show SMILES OC(=O)[C@H]1C[C@H]1COc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1F
Show InChI InChI=1S/C23H19FO4/c24-22-11-10-19(28-18-4-2-1-3-5-18)13-20(22)15-6-8-17(9-7-15)27-14-16-12-21(16)23(25)26/h1-11,13,16,21H,12,14H2,(H,25,26)/t16-,21-/m0/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384305
PNG
((Trans)-(+/−)-2-(((2′,3-difluoro-5R...)
Show SMILES OC(=O)[C@H]1C[C@@H]1COc1ccc(cc1F)-c1cc(Oc2ccccc2)ccc1F
Show InChI InChI=1S/C23H18F2O4/c24-20-8-7-17(29-16-4-2-1-3-5-16)12-18(20)14-6-9-22(21(25)11-14)28-13-15-10-19(15)23(26)27/h1-9,11-12,15,19H,10,13H2,(H,26,27)/t15-,19+/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384322
PNG
((1R,2R)-2-(((3′-Chloro-3-fluoro-5′-iso...)
Show SMILES CC(C)Oc1cc(Cl)cc(c1)-c1ccc(OC[C@@H]2C[C@H]2C(O)=O)c(F)c1
Show InChI InChI=1S/C20H20ClFO4/c1-11(2)26-16-6-13(5-15(21)9-16)12-3-4-19(18(22)8-12)25-10-14-7-17(14)20(23)24/h3-6,8-9,11,14,17H,7,10H2,1-2H3,(H,23,24)/t14-,17+/m0/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384301
PNG
((1R,2S)-2-(((2′-Fluoro-5′-isopropoxy-[...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OC[C@H]2C[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C20H21FO4/c1-12(2)25-16-7-8-19(21)17(10-16)13-3-5-15(6-4-13)24-11-14-9-18(14)20(22)23/h3-8,10,12,14,18H,9,11H2,1-2H3,(H,22,23)/t14-,18-/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386913
PNG
(US9938222, Example 42)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(Oc2cccc(F)c2)ccc1F
Show InChI InChI=1S/C23H18F2O4/c24-16-2-1-3-18(11-16)29-19-8-9-22(25)20(12-19)14-4-6-17(7-5-14)28-13-15-10-21(15)23(26)27/h1-9,11-12,15,21H,10,13H2,(H,26,27)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386922
PNG
(US9938222, Example 51 | US9938222, Example 52 | US...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H14F4O4/c19-16-6-5-13(26-18(20,21)22)8-14(16)10-1-3-12(4-2-10)25-9-11-7-15(11)17(23)24/h1-6,8,11,15H,7,9H2,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386932
PNG
(US9938222, Example 61)
Show SMILES CC(C)Oc1cc(F)c(F)c(c1)-c1ccc(OCC2CC2C(O)=O)cc1F
Show InChI InChI=1S/C20H19F3O4/c1-10(2)27-13-6-16(19(23)18(22)8-13)14-4-3-12(7-17(14)21)26-9-11-5-15(11)20(24)25/h3-4,6-8,10-11,15H,5,9H2,1-2H3,(H,24,25)
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US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386957
PNG
(Trans-2-(((3′-isopropoxy-5′-(methoxyme...)
Show SMILES CC(C)Oc1cc(CCO)cc(c1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C22H26O5/c1-14(2)27-20-10-15(7-8-23)9-17(11-20)16-3-5-19(6-4-16)26-13-18-12-21(18)22(24)25/h3-6,9-11,14,18,21,23H,7-8,12-13H2,1-2H3,(H,24,25)
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US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386960
PNG
(Trans-2-(((2′-fluoro-5′-isopropoxy-3-(...)
Show SMILES COCCc1cc(ccc1OCC1CC1C(O)=O)-c1cc(OC(C)C)ccc1F
Show InChI InChI=1S/C23H27FO5/c1-14(2)29-18-5-6-21(24)19(12-18)15-4-7-22(16(10-15)8-9-27-3)28-13-17-11-20(17)23(25)26/h4-7,10,12,14,17,20H,8-9,11,13H2,1-3H3,(H,25,26)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386967
PNG
(Trans-2-(((2′,3-difluoro-5′-(3-fluorop...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1F)-c1cc(Oc2cccc(F)c2)ccc1F
Show InChI InChI=1S/C23H17F3O4/c24-15-2-1-3-16(10-15)30-17-5-6-20(25)18(11-17)13-4-7-22(21(26)9-13)29-12-14-8-19(14)23(27)28/h1-7,9-11,14,19H,8,12H2,(H,27,28)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386978
PNG
(US9938222, Example 107 | US9938222, Example 108 | ...)
Show SMILES Cc1ccc(Oc2cc(F)c(F)c(c2)-c2ccc(OCC3CC3C(O)=O)c(F)c2)cc1F
Show InChI InChI=1S/C24H18F4O4/c1-12-2-4-15(9-19(12)25)32-16-8-17(23(28)21(27)10-16)13-3-5-22(20(26)7-13)31-11-14-6-18(14)24(29)30/h2-5,7-10,14,18H,6,11H2,1H3,(H,29,30)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386988
PNG
(US9938222, Example 117)
Show SMILES COc1cc(OC(C)C)cc(c1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H24O5/c1-13(2)26-19-9-15(8-18(11-19)24-3)14-4-6-17(7-5-14)25-12-16-10-20(16)21(22)23/h4-9,11,13,16,20H,10,12H2,1-3H3,(H,22,23)
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Bristol-Myers Squibb Company

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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386991
PNG
(US9938222, Example 120)
Show SMILES CC(C)Oc1cc(Cl)cc(c1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C20H21ClO4/c1-12(2)25-18-8-14(7-16(21)10-18)13-3-5-17(6-4-13)24-11-15-9-19(15)20(22)23/h3-8,10,12,15,19H,9,11H2,1-2H3,(H,22,23)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386992
PNG
(US9938222, Example 121)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(ccc1Cl)C(F)(F)F
Show InChI InChI=1S/C18H14ClF3O3/c19-16-6-3-12(18(20,21)22)8-14(16)10-1-4-13(5-2-10)25-9-11-7-15(11)17(23)24/h1-6,8,11,15H,7,9H2,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386994
PNG
(US9938222, Example 123)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(ccc1F)C(F)(F)F
Show InChI InChI=1S/C18H14F4O3/c19-16-6-3-12(18(20,21)22)8-14(16)10-1-4-13(5-2-10)25-9-11-7-15(11)17(23)24/h1-6,8,11,15H,7,9H2,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384295
PNG
(Cis-2-(((2′-fluoro-5′-phenoxy-[1,1R...)
Show SMILES OC(=O)[C@@H]1C[C@@H]1COc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1F
Show InChI InChI=1S/C23H19FO4/c24-22-11-10-19(28-18-4-2-1-3-5-18)13-20(22)15-6-8-17(9-7-15)27-14-16-12-21(16)23(25)26/h1-11,13,16,21H,12,14H2,(H,25,26)/t16-,21-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384345
PNG
(Trans-2-(((2′-chloro-3-fluoro-5′-isopr...)
Show SMILES CC(C)Oc1ccc(Cl)c(c1)-c1ccc(OCC2CC2C(O)=O)c(F)c1
Show InChI InChI=1S/C20H20ClFO4/c1-11(2)26-14-4-5-17(21)15(9-14)12-3-6-19(18(22)8-12)25-10-13-7-16(13)20(23)24/h3-6,8-9,11,13,16H,7,10H2,1-2H3,(H,23,24)
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US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385613
PNG
((1R,2R)-2-(4-(5-Chloro-2,2-dimethyl-2,3-dihydroben...)
Show SMILES CC1(C)Cc2cc(Cl)cc(c2O1)-c1ccc(CC[C@@H]2C[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C22H23ClO3/c1-22(2)12-16-9-17(23)11-18(20(16)26-22)14-6-3-13(4-7-14)5-8-15-10-19(15)21(24)25/h3-4,6-7,9,11,15,19H,5,8,10,12H2,1-2H3,(H,24,25)/t15-,19-/m1/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385715
PNG
(Trans-2-(2-((2′-fluoro-5′-isopropoxy-[...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(CC2CC2CC(O)=O)cc1
Show InChI InChI=1S/C21H23FO3/c1-13(2)25-18-7-8-20(22)19(12-18)15-5-3-14(4-6-15)9-16-10-17(16)11-21(23)24/h3-8,12-13,16-17H,9-11H2,1-2H3,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385807
PNG
(Trans-(2-((2′-fluoro-5′-isopropoxy-[1,...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(C[C@H]2C[C@@H]2CC(O)=O)cc1
Show InChI InChI=1S/C21H23FO3/c1-13(2)25-18-7-8-20(22)19(12-18)15-5-3-14(4-6-15)9-16-10-17(16)11-21(23)24/h3-8,12-13,16-17H,9-11H2,1-2H3,(H,23,24)/t16-,17+/m0/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386921
PNG
(US9938222, Example 50)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(OC2CCCC2)ccc1F
Show InChI InChI=1S/C22H23FO4/c23-21-10-9-18(27-17-3-1-2-4-17)12-19(21)14-5-7-16(8-6-14)26-13-15-11-20(15)22(24)25/h5-10,12,15,17,20H,1-4,11,13H2,(H,24,25)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386927
PNG
(US9938222, Example 56 | US9938222, Example 57 | US...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(F)ccc1Oc1ccccc1
Show InChI InChI=1S/C23H19FO4/c24-17-8-11-22(28-19-4-2-1-3-5-19)20(13-17)15-6-9-18(10-7-15)27-14-16-12-21(16)23(25)26/h1-11,13,16,21H,12,14H2,(H,25,26)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386934
PNG
(US9938222, Example 63)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OC[C@@H]2C[C@H]2C(O)=O)c(F)c1
Show InChI InChI=1S/C20H20F2O4/c1-11(2)26-14-4-5-17(21)15(9-14)12-3-6-19(18(22)8-12)25-10-13-7-16(13)20(23)24/h3-6,8-9,11,13,16H,7,10H2,1-2H3,(H,23,24)/t13-,16+/m0/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386949
PNG
(US9938222, Example 78)
Show SMILES COc1ncc(Cl)cc1-c1ccc(CCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C18H18ClNO3/c1-23-17-15(9-14(19)10-20-17)12-5-2-11(3-6-12)4-7-13-8-16(13)18(21)22/h2-3,5-6,9-10,13,16H,4,7-8H2,1H3,(H,21,22)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386951
PNG
(US9938222, Example 80)
Show SMILES COc1ccc(F)cc1-c1ccc(CCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C19H19FO3/c1-23-18-9-8-15(20)11-16(18)13-5-2-12(3-6-13)4-7-14-10-17(14)19(21)22/h2-3,5-6,8-9,11,14,17H,4,7,10H2,1H3,(H,21,22)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386963
PNG
(Trans-2-(((5′-(4-Chlorophenoxy)-2′-flu...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(Oc2ccc(Cl)cc2)ccc1F
Show InChI InChI=1S/C23H18ClFO4/c24-16-3-7-18(8-4-16)29-19-9-10-22(25)20(12-19)14-1-5-17(6-2-14)28-13-15-11-21(15)23(26)27/h1-10,12,15,21H,11,13H2,(H,26,27)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386997
PNG
(US9938222, Example 126)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C23H20O3/c24-23(25)22-14-20(22)15-26-21-11-9-17(10-12-21)19-8-4-7-18(13-19)16-5-2-1-3-6-16/h1-13,20,22H,14-15H2,(H,24,25)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM387002
PNG
(US9938222, Example 131)
Show SMILES CC(C)Oc1cccc(c1)-c1ccc(CCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H24O3/c1-14(2)24-19-5-3-4-17(12-19)16-9-6-15(7-10-16)8-11-18-13-20(18)21(22)23/h3-7,9-10,12,14,18,20H,8,11,13H2,1-2H3,(H,22,23)
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US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM387004
PNG
(US9938222, Example 133)
Show SMILES CC(C)Oc1ccc(Cl)c(c1)-c1ccc(CCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H23ClO3/c1-13(2)25-17-9-10-20(22)18(12-17)15-6-3-14(4-7-15)5-8-16-11-19(16)21(23)24/h3-4,6-7,9-10,12-13,16,19H,5,8,11H2,1-2H3,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384288
PNG
(Trans-2-(((2′-fluoro-5′-isopropoxy-[1,...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C20H21FO4/c1-12(2)25-16-7-8-19(21)17(10-16)13-3-5-15(6-4-13)24-11-14-9-18(14)20(22)23/h3-8,10,12,14,18H,9,11H2,1-2H3,(H,22,23)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384302
PNG
((1S,2R)-2-(((2′-Fluoro-5′-isopropoxy-[...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OC[C@@H]2C[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C20H21FO4/c1-12(2)25-16-7-8-19(21)17(10-16)13-3-5-15(6-4-13)24-11-14-9-18(14)20(22)23/h3-8,10,12,14,18H,9,11H2,1-2H3,(H,22,23)/t14-,18-/m0/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384320
PNG
(Trans-2-(((3′-chloro-3-fluoro-5′-isopr...)
Show SMILES CC(C)Oc1cc(Cl)cc(c1)-c1ccc(OC[C@H]2C[C@@H]2C(O)=O)c(F)c1
Show InChI InChI=1S/C20H20ClFO4/c1-11(2)26-16-6-13(5-15(21)9-16)12-3-4-19(18(22)8-12)25-10-14-7-17(14)20(23)24/h3-6,8-9,11,14,17H,7,10H2,1-2H3,(H,23,24)/t14-,17+/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385615
PNG
(Trans-2-(4-(2-methyl-4-phenylthiazol-5-yl)phenethy...)
Show SMILES Cc1nc(c(s1)-c1ccc(CC[C@@H]2C[C@H]2C(O)=O)cc1)-c1ccccc1
Show InChI InChI=1S/C22H21NO2S/c1-14-23-20(16-5-3-2-4-6-16)21(26-14)17-10-7-15(8-11-17)9-12-18-13-19(18)22(24)25/h2-8,10-11,18-19H,9,12-13H2,1H3,(H,24,25)/t18-,19-/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385692
PNG
((1R,2R)-2-(2-(2′-fluoro-5′-isopropoxy-...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(CC[C@@H]2C[C@H]2C(O)=O)cc1
Show InChI InChI=1S/C21H23FO3/c1-13(2)25-17-9-10-20(22)18(12-17)15-6-3-14(4-7-15)5-8-16-11-19(16)21(23)24/h3-4,6-7,9-10,12-13,16,19H,5,8,11H2,1-2H3,(H,23,24)/t16-,19-/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385744
PNG
(Trans-(2-((2′-fluoro-5′-isopropoxy-[1,...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(C[C@@H]2C[C@H]2CC(O)=O)cc1
Show InChI InChI=1S/C21H23FO3/c1-13(2)25-18-7-8-20(22)19(12-18)15-5-3-14(4-6-15)9-16-10-17(16)11-21(23)24/h3-8,12-13,16-17H,9-11H2,1-2H3,(H,23,24)/t16-,17+/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385824
PNG
(Trans-2-(2-(3′-(ethylthio)-[1,1′-biphe...)
Show SMILES CCSc1cccc(c1)-c1ccc(CCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C20H22O2S/c1-2-23-18-5-3-4-16(12-18)15-9-6-14(7-10-15)8-11-17-13-19(17)20(21)22/h3-7,9-10,12,17,19H,2,8,11,13H2,1H3,(H,21,22)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385829
PNG
(Trans-2-fluoro-2-(2-(2′-fluoro-5′-isop...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(CC[C@]2(F)C[C@@H]2C(O)=O)cc1
Show InChI InChI=1S/C21H22F2O3/c1-13(2)26-16-7-8-19(22)17(11-16)15-5-3-14(4-6-15)9-10-21(23)12-18(21)20(24)25/h3-8,11,13,18H,9-10,12H2,1-2H3,(H,24,25)/t18-,21+/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386914
PNG
(US9938222, Example 43)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(Oc2cc(F)cc(F)c2)ccc1F
Show InChI InChI=1S/C23H17F3O4/c24-15-8-16(25)10-19(9-15)30-18-5-6-22(26)20(11-18)13-1-3-17(4-2-13)29-12-14-7-21(14)23(27)28/h1-6,8-11,14,21H,7,12H2,(H,27,28)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386917
PNG
(US9938222, Example 46)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OCC2CC2C(O)=O)c(C)c1
Show InChI InChI=1S/C21H23FO4/c1-12(2)26-16-5-6-19(22)17(10-16)14-4-7-20(13(3)8-14)25-11-15-9-18(15)21(23)24/h4-8,10,12,15,18H,9,11H2,1-3H3,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386920
PNG
(US9938222, Example 49)
Show SMILES CC(C)Oc1cc(c(F)c(c1)C(F)(F)F)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H20F4O4/c1-11(2)29-15-8-16(19(22)18(9-15)21(23,24)25)12-3-5-14(6-4-12)28-10-13-7-17(13)20(26)27/h3-6,8-9,11,13,17H,7,10H2,1-2H3,(H,26,27)
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US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386926
PNG
(US9938222, Example 55)
Show SMILES CC(C)Oc1cc(F)cc(c1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C20H21FO4/c1-12(2)25-18-8-14(7-16(21)10-18)13-3-5-17(6-4-13)24-11-15-9-19(15)20(22)23/h3-8,10,12,15,19H,9,11H2,1-2H3,(H,22,23)
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US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386927
PNG
(US9938222, Example 56 | US9938222, Example 57 | US...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(F)ccc1Oc1ccccc1
Show InChI InChI=1S/C23H19FO4/c24-17-8-11-22(28-19-4-2-1-3-5-19)20(13-17)15-6-9-18(10-7-15)27-14-16-12-21(16)23(25)26/h1-11,13,16,21H,12,14H2,(H,25,26)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386935
PNG
(US9938222, Example 64)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OC[C@H]2C[C@@H]2C(O)=O)c(F)c1
Show InChI InChI=1S/C20H20F2O4/c1-11(2)26-14-4-5-17(21)15(9-14)12-3-6-19(18(22)8-12)25-10-13-7-16(13)20(23)24/h3-6,8-9,11,13,16H,7,10H2,1-2H3,(H,23,24)/t13-,16+/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386946
PNG
(US9938222, Example 75)
Show SMILES OC(=O)C1CC1CCc1ccc(cc1)-c1cccc(Oc2ccccc2)c1
Show InChI InChI=1S/C24H22O3/c25-24(26)23-16-20(23)14-11-17-9-12-18(13-10-17)19-5-4-8-22(15-19)27-21-6-2-1-3-7-21/h1-10,12-13,15,20,23H,11,14,16H2,(H,25,26)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386959
PNG
(Trans-2-(((2′-fluoro-5′-isopropoxy-3-(...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(OCC2CC2C(O)=O)c(c1)C(F)(F)F
Show InChI InChI=1S/C21H20F4O4/c1-11(2)29-14-4-5-18(22)15(9-14)12-3-6-19(17(8-12)21(23,24)25)28-10-13-7-16(13)20(26)27/h3-6,8-9,11,13,16H,7,10H2,1-2H3,(H,26,27)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386965
PNG
(US9938222, Example 94)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(OC2CCC2)ccc1F
Show InChI InChI=1S/C21H21FO4/c22-20-9-8-17(26-16-2-1-3-16)11-18(20)13-4-6-15(7-5-13)25-12-14-10-19(14)21(23)24/h4-9,11,14,16,19H,1-3,10,12H2,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386984
PNG
(US9938222, Example 113)
Show SMILES OC(=O)[C@H]1CC1COc1ccc(cc1)-c1cc(Oc2cccc(F)c2)cnc1Cl
Show InChI InChI=1S/C22H17ClFNO4/c23-21-19(10-18(11-25-21)29-17-3-1-2-15(24)9-17)13-4-6-16(7-5-13)28-12-14-8-20(14)22(26)27/h1-7,9-11,14,20H,8,12H2,(H,26,27)/t14?,20-/m0/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386999
PNG
(US9938222, Example 128)
Show SMILES OC(=O)C1CC1CCc1ccc(cc1)-c1cccc(c1)-n1cccn1
Show InChI InChI=1S/C21H20N2O2/c24-21(25)20-14-18(20)10-7-15-5-8-16(9-6-15)17-3-1-4-19(13-17)23-12-2-11-22-23/h1-6,8-9,11-13,18,20H,7,10,14H2,(H,24,25)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384295
PNG
(Cis-2-(((2′-fluoro-5′-phenoxy-[1,1R...)
Show SMILES OC(=O)[C@@H]1C[C@@H]1COc1ccc(cc1)-c1cc(Oc2ccccc2)ccc1F
Show InChI InChI=1S/C23H19FO4/c24-22-11-10-19(28-18-4-2-1-3-5-18)13-20(22)15-6-8-17(9-7-15)27-14-16-12-21(16)23(25)26/h1-11,13,16,21H,12,14H2,(H,25,26)/t16-,21-/m1/s1
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384348
PNG
(Trans-2-((4-(6-fluoro-2,2-dimethyl-2,3-dihydrobenz...)
Show SMILES CC1(C)Cc2c(O1)cc(F)cc2-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H21FO4/c1-21(2)10-18-16(8-14(22)9-19(18)26-21)12-3-5-15(6-4-12)25-11-13-7-17(13)20(23)24/h3-6,8-9,13,17H,7,10-11H2,1-2H3,(H,23,24)
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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM384353
PNG
(2-((4-(5-Fluoro-2,2-dimethyl-2,3-dihydrobenzofuran...)
Show SMILES CC1(C)Cc2c(O1)ccc(F)c2-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C21H21FO4/c1-21(2)10-16-18(26-21)8-7-17(22)19(16)12-3-5-14(6-4-12)25-11-13-9-15(13)20(23)24/h3-8,13,15H,9-11H2,1-2H3,(H,23,24)
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n/an/an/an/a 1.25E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385715
PNG
(Trans-2-(2-((2′-fluoro-5′-isopropoxy-[...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(CC2CC2CC(O)=O)cc1
Show InChI InChI=1S/C21H23FO3/c1-13(2)25-18-7-8-20(22)19(12-18)15-5-3-14(4-6-15)9-16-10-17(16)11-21(23)24/h3-8,12-13,16-17H,9-11H2,1-2H3,(H,23,24)
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Bristol-Myers Squibb Company

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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM385822
PNG
(Trans-2-((2′-fluoro-5′-isopropoxy-[1,1...)
Show SMILES CC(C)Oc1ccc(F)c(c1)-c1ccc(COC2CC2C(O)=O)cc1
Show InChI InChI=1S/C20H21FO4/c1-12(2)25-15-7-8-18(21)16(9-15)14-5-3-13(4-6-14)11-24-19-10-17(19)20(22)23/h3-9,12,17,19H,10-11H2,1-2H3,(H,22,23)
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n/an/an/an/a 2.65E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386915
PNG
(US9938222, Example 44)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(Oc2ccc(F)cc2)ccc1F
Show InChI InChI=1S/C23H18F2O4/c24-16-3-7-18(8-4-16)29-19-9-10-22(25)20(12-19)14-1-5-17(6-2-14)28-13-15-11-21(15)23(26)27/h1-10,12,15,21H,11,13H2,(H,26,27)
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n/an/an/an/a 270n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386919
PNG
(US9938222, Example 48)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(Cl)cc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H14ClF3O4/c19-13-5-11(6-15(8-13)26-18(20,21)22)10-1-3-14(4-2-10)25-9-12-7-16(12)17(23)24/h1-6,8,12,16H,7,9H2,(H,23,24)
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n/an/an/an/a 760n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386922
PNG
(US9938222, Example 51 | US9938222, Example 52 | US...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(OC(F)(F)F)ccc1F
Show InChI InChI=1S/C18H14F4O4/c19-16-6-5-13(26-18(20,21)22)8-14(16)10-1-3-12(4-2-10)25-9-11-7-15(11)17(23)24/h1-6,8,11,15H,7,9H2,(H,23,24)
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n/an/an/an/a 470n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386936
PNG
(US9938222, Example 65)
Show SMILES CC(C)Oc1cc(F)c(F)c(c1)-c1ccc(OCC2CC2C(O)=O)c(F)c1
Show InChI InChI=1S/C20H19F3O4/c1-10(2)27-13-7-14(19(23)17(22)8-13)11-3-4-18(16(21)6-11)26-9-12-5-15(12)20(24)25/h3-4,6-8,10,12,15H,5,9H2,1-2H3,(H,24,25)
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n/an/an/an/a 330n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386939
PNG
(US9938222, Example 68)
Show SMILES CCOc1ccc(F)c(c1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C19H19FO4/c1-2-23-15-7-8-18(20)16(10-15)12-3-5-14(6-4-12)24-11-13-9-17(13)19(21)22/h3-8,10,13,17H,2,9,11H2,1H3,(H,21,22)
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n/an/an/an/a 660n/an/an/an/a



Bristol-Myers Squibb Company

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Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386941
PNG
(US9938222, Example 70)
Show SMILES CC(C)Oc1cc(c(F)cn1)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C19H20FNO4/c1-11(2)25-18-8-15(17(20)9-21-18)12-3-5-14(6-4-12)24-10-13-7-16(13)19(22)23/h3-6,8-9,11,13,16H,7,10H2,1-2H3,(H,22,23)
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n/an/an/an/a 2.40E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386952
PNG
(US9938222, Example 81)
Show SMILES CCOc1ccc(F)cc1-c1ccc(CCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C20H21FO3/c1-2-24-19-10-9-16(21)12-17(19)14-6-3-13(4-7-14)5-8-15-11-18(15)20(22)23/h3-4,6-7,9-10,12,15,18H,2,5,8,11H2,1H3,(H,22,23)
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n/an/an/an/a 1.25E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386954
PNG
(Trans-2-((4-(1-benzyl-1H-pyrazol-4-yl)phenoxy)meth...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cnn(Cc2ccccc2)c1
Show InChI InChI=1S/C21H20N2O3/c24-21(25)20-10-17(20)14-26-19-8-6-16(7-9-19)18-11-22-23(13-18)12-15-4-2-1-3-5-15/h1-9,11,13,17,20H,10,12,14H2,(H,24,25)
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n/an/an/an/a 3.05E+3n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386971
PNG
(US9938222, Example 100 | US9938222, Example 101 | ...)
Show SMILES Cc1ccc(Oc2ccc(F)c(c2)-c2ccc(OCC3CC3C(O)=O)c(F)c2)cc1F
Show InChI InChI=1S/C24H19F3O4/c1-13-2-4-17(11-21(13)26)31-16-5-6-20(25)18(10-16)14-3-7-23(22(27)9-14)30-12-15-8-19(15)24(28)29/h2-7,9-11,15,19H,8,12H2,1H3,(H,28,29)
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Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386977
PNG
(US9938222, Example 106)
Show SMILES OC(=O)[C@@H]1C[C@H]1COc1ccc(cc1F)-c1cc(Oc2cccc(F)c2)cc(F)c1F
Show InChI InChI=1S/C23H16F4O4/c24-14-2-1-3-15(8-14)31-16-9-17(22(27)20(26)10-16)12-4-5-21(19(25)7-12)30-11-13-6-18(13)23(28)29/h1-5,7-10,13,18H,6,11H2,(H,28,29)/t13-,18+/m0/s1
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Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386981
PNG
(Trans-2-((4-(2-chloro-5-phenoxypyridin-3-yl)phenox...)
Show SMILES OC(=O)C1CC1COc1ccc(cc1)-c1cc(Oc2ccccc2)cnc1Cl
Show InChI InChI=1S/C22H18ClNO4/c23-21-19(11-18(12-24-21)28-17-4-2-1-3-5-17)14-6-8-16(9-7-14)27-13-15-10-20(15)22(25)26/h1-9,11-12,15,20H,10,13H2,(H,25,26)
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n/an/an/an/a 430n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
G-protein coupled receptor 120


(Homo sapiens (Human))
BDBM386998
PNG
(US9938222, Example 127)
Show SMILES CC(C)Oc1ccc(F)c(c1F)-c1ccc(OCC2CC2C(O)=O)cc1
Show InChI InChI=1S/C20H20F2O4/c1-11(2)26-17-8-7-16(21)18(19(17)22)12-3-5-14(6-4-12)25-10-13-9-15(13)20(23)24/h3-8,11,13,15H,9-10H2,1-2H3,(H,23,24)
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n/an/an/an/a 940n/an/an/an/a



Bristol-Myers Squibb Company

US Patent


Assay Description
For the pERK assay, 3106 cells/mL cryopreserved human and mouse cells were thawed rapidly in a 37 C. water bath and added to a T-225 flask containi...


US Patent US9938222 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%