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Patent code US9938257

Compile Data Set for Download or QSAR
Found 57 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387172
PNG
(3-(5-((5-chloro-2-((1-(6-methoxypyridin-3-yl)-1H-p...)
Show SMILES COc1ccc(cn1)-n1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)CC#N)n2)cn1
Show InChI InChI=1S/C23H24ClN9O2/c1-35-20-3-2-18(9-26-20)33-13-17(8-28-33)30-23-27-10-19(24)22(31-23)29-16-6-14-11-32(12-15(14)7-16)21(34)4-5-25/h2-3,8-10,13-16H,4,6-7,11-12H2,1H3,(H2,27,29,30,31)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387194
PNG
(5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C20H29ClN8O3S/c1-12(30)8-28-11-17(6-23-28)25-20-22-7-18(21)19(26-20)24-16-4-13-9-29(10-14(13)5-16)33(31,32)27-15-2-3-15/h6-7,11-16,27,30H,2-5,8-10H2,1H3,(H2,22,24,25,26)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387171
PNG
(3-(5-((5-chloro-2-((1-(pyridin-2-yl)-1H-pyrazol-4-...)
Show SMILES Clc1cnc(Nc2cnn(c2)-c2ccccn2)nc1NC1CC2CN(CC2C1)C(=O)CC#N
Show InChI InChI=1S/C22H22ClN9O/c23-18-10-26-22(29-17-9-27-32(13-17)19-3-1-2-6-25-19)30-21(18)28-16-7-14-11-31(12-15(14)8-16)20(33)4-5-24/h1-3,6,9-10,13-16H,4,7-8,11-12H2,(H2,26,28,29,30)
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US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387182
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES CCNS(=O)(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C17H25ClN8O2S/c1-3-21-29(27,28)26-8-11-4-13(5-12(11)9-26)22-16-15(18)7-19-17(24-16)23-14-6-20-25(2)10-14/h6-7,10-13,21H,3-5,8-9H2,1-2H3,(H2,19,22,23,24)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387192
PNG
(5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-...)
Show SMILES CCNS(=O)(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(CC(C)O)c2)ncc1Cl
Show InChI InChI=1S/C19H29ClN8O3S/c1-3-23-32(30,31)28-9-13-4-15(5-14(13)10-28)24-18-17(20)7-21-19(26-18)25-16-6-22-27(11-16)8-12(2)29/h6-7,11-15,23,29H,3-5,8-10H2,1-2H3,(H2,21,24,25,26)
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US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387186
PNG
(1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocy...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(C)(=O)=O)n2)cn1
Show InChI InChI=1S/C18H26ClN7O3S/c1-11(27)7-25-10-15(5-21-25)23-18-20-6-16(19)17(24-18)22-14-3-12-8-26(30(2,28)29)9-13(12)4-14/h5-6,10-14,27H,3-4,7-9H2,1-2H3,(H2,20,22,23,24)
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US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387184
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C18H25ClN8O2S/c1-26-10-15(6-21-26)23-18-20-7-16(19)17(24-18)22-14-4-11-8-27(9-12(11)5-14)30(28,29)25-13-2-3-13/h6-7,10-14,25H,2-5,8-9H2,1H3,(H2,20,22,23,24)
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US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387187
PNG
(1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocy...)
Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(C)(=O)=O)n2)cn1
Show InChI InChI=1S/C19H28ClN7O3S/c1-19(2,28)11-26-10-15(6-22-26)24-18-21-7-16(20)17(25-18)23-14-4-12-8-27(31(3,29)30)9-13(12)5-14/h6-7,10,12-14,28H,4-5,8-9,11H2,1-3H3,(H2,21,23,24,25)
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US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387181
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C19H25ClN8O/c1-27-10-15(6-22-27)24-18-21-7-16(20)17(26-18)23-14-4-11-8-28(9-12(11)5-14)19(29)25-13-2-3-13/h6-7,10-14H,2-5,8-9H2,1H3,(H,25,29)(H2,21,23,24,26)
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US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387186
PNG
(1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocy...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(C)(=O)=O)n2)cn1
Show InChI InChI=1S/C18H26ClN7O3S/c1-11(27)7-25-10-15(5-21-25)23-18-20-6-16(19)17(24-18)22-14-3-12-8-26(30(2,28)29)9-13(12)4-14/h5-6,10-14,27H,3-4,7-9H2,1-2H3,(H2,20,22,23,24)
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US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387191
PNG
(1-(4-((5-chloro-4-((2-(cyclopropylsulfonyl)octahyd...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)C3CC3)n2)cn1
Show InChI InChI=1S/C20H28ClN7O3S/c1-12(29)8-27-11-16(6-23-27)25-20-22-7-18(21)19(26-20)24-15-4-13-9-28(10-14(13)5-15)32(30,31)17-2-3-17/h6-7,11-15,17,29H,2-5,8-10H2,1H3,(H2,22,24,25,26)
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US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387193
PNG
(1-(4-((5-chloro-4-((2-((cyclopropylmethyl)sulfonyl...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)CC3CC3)n2)cn1
Show InChI InChI=1S/C21H30ClN7O3S/c1-13(30)8-28-11-18(6-24-28)26-21-23-7-19(22)20(27-21)25-17-4-15-9-29(10-16(15)5-17)33(31,32)12-14-2-3-14/h6-7,11,13-17,30H,2-5,8-10,12H2,1H3,(H2,23,25,26,27)
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US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387186
PNG
(1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocy...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(C)(=O)=O)n2)cn1
Show InChI InChI=1S/C18H26ClN7O3S/c1-11(27)7-25-10-15(5-21-25)23-18-20-6-16(19)17(24-18)22-14-3-12-8-26(30(2,28)29)9-13(12)4-14/h5-6,10-14,27H,3-4,7-9H2,1-2H3,(H2,20,22,23,24)
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US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387184
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C18H25ClN8O2S/c1-26-10-15(6-21-26)23-18-20-7-16(19)17(24-18)22-14-4-11-8-27(9-12(11)5-14)30(28,29)25-13-2-3-13/h6-7,10-14,25H,2-5,8-9H2,1H3,(H2,20,22,23,24)
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US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387180
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H25ClN8O/c1-3-20-18(28)27-8-11-4-13(5-12(11)9-27)23-16-15(19)7-21-17(25-16)24-14-6-22-26(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H,20,28)(H2,21,23,24,25)
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US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387182
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES CCNS(=O)(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C17H25ClN8O2S/c1-3-21-29(27,28)26-8-11-4-13(5-12(11)9-26)22-16-15(18)7-19-17(24-16)23-14-6-20-25(2)10-14/h6-7,10-13,21H,3-5,8-9H2,1-2H3,(H2,19,22,23,24)
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US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387170
PNG
(3-(5-((5-chloro-2-((1-(2-hydroxy-2-methylpropyl)-1...)
Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)CC#N)n2)cn1
Show InChI InChI=1S/C21H27ClN8O2/c1-21(2,32)12-30-11-16(7-25-30)27-20-24-8-17(22)19(28-20)26-15-5-13-9-29(10-14(13)6-15)18(31)3-4-23/h7-8,11,13-15,32H,3,5-6,9-10,12H2,1-2H3,(H2,24,26,27,28)
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US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387185
PNG
(1-(4-((5-chloro-4-((3-(methylsulfonyl)-3-azaspiro[...)
Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(CC4)S(C)(=O)=O)n2)cn1
Show InChI InChI=1S/C22H34ClN7O3S/c1-21(2,31)15-29-14-17(12-25-29)27-20-24-13-18(23)19(28-20)26-16-4-6-22(7-5-16)8-10-30(11-9-22)34(3,32)33/h12-14,16,31H,4-11,15H2,1-3H3,(H2,24,26,27,28)
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US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase B


(Homo sapiens (Human))
BDBM387177
PNG
(US9938257, Example 15 | ethyl 5-((5-chloro-2-((1-m...)
Show SMILES CCOC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H24ClN7O2/c1-3-28-18(27)26-8-11-4-13(5-12(11)9-26)22-16-15(19)7-20-17(24-16)23-14-6-21-25(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H2,20,22,23,24)
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US Patent


Assay Description
Aurora-B:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387187
PNG
(1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocy...)
Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(C)(=O)=O)n2)cn1
Show InChI InChI=1S/C19H28ClN7O3S/c1-19(2,28)11-26-10-15(6-22-26)24-18-21-7-16(20)17(25-18)23-14-4-12-8-27(31(3,29)30)9-13(12)5-14/h6-7,10,12-14,28H,4-5,8-9,11H2,1-3H3,(H2,21,23,24,25)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387187
PNG
(1-(4-((5-chloro-4-((2-(methyl sulfonyl)octahydrocy...)
Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(C)(=O)=O)n2)cn1
Show InChI InChI=1S/C19H28ClN7O3S/c1-19(2,28)11-26-10-15(6-22-26)24-18-21-7-16(20)17(25-18)23-14-4-12-8-27(31(3,29)30)9-13(12)5-14/h6-7,10,12-14,28H,4-5,8-9,11H2,1-3H3,(H2,21,23,24,25)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387184
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C18H25ClN8O2S/c1-26-10-15(6-21-26)23-18-20-7-16(19)17(24-18)22-14-4-11-8-27(9-12(11)5-14)30(28,29)25-13-2-3-13/h6-7,10-14,25H,2-5,8-9H2,1H3,(H2,20,22,23,24)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387182
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES CCNS(=O)(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C17H25ClN8O2S/c1-3-21-29(27,28)26-8-11-4-13(5-12(11)9-26)22-16-15(18)7-19-17(24-16)23-14-6-20-25(2)10-14/h6-7,10-13,21H,3-5,8-9H2,1-2H3,(H2,19,22,23,24)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387172
PNG
(3-(5-((5-chloro-2-((1-(6-methoxypyridin-3-yl)-1H-p...)
Show SMILES COc1ccc(cn1)-n1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)CC#N)n2)cn1
Show InChI InChI=1S/C23H24ClN9O2/c1-35-20-3-2-18(9-26-20)33-13-17(8-28-33)30-23-27-10-19(24)22(31-23)29-16-6-14-11-32(12-15(14)7-16)21(34)4-5-25/h2-3,8-10,13-16H,4,6-7,11-12H2,1H3,(H2,27,29,30,31)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387192
PNG
(5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-...)
Show SMILES CCNS(=O)(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(CC(C)O)c2)ncc1Cl
Show InChI InChI=1S/C19H29ClN8O3S/c1-3-23-32(30,31)28-9-13-4-15(5-14(13)10-28)24-18-17(20)7-21-19(26-18)25-16-6-22-27(11-16)8-12(2)29/h6-7,11-15,23,29H,3-5,8-10H2,1-2H3,(H2,21,24,25,26)
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US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387191
PNG
(1-(4-((5-chloro-4-((2-(cyclopropylsulfonyl)octahyd...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)C3CC3)n2)cn1
Show InChI InChI=1S/C20H28ClN7O3S/c1-12(29)8-27-11-16(6-23-27)25-20-22-7-18(21)19(26-20)24-15-4-13-9-28(10-14(13)5-15)32(30,31)17-2-3-17/h6-7,11-15,17,29H,2-5,8-10H2,1H3,(H2,22,24,25,26)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387175
PNG
(5-chloro-N4-(2-(cyclopropylsulfonyl)octahydrocyclo...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)C3CC3)n2)cn1
Show InChI InChI=1S/C18H24ClN7O2S/c1-25-10-14(6-21-25)23-18-20-7-16(19)17(24-18)22-13-4-11-8-26(9-12(11)5-13)29(27,28)15-2-3-15/h6-7,10-13,15H,2-5,8-9H2,1H3,(H2,20,22,23,24)
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US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387176
PNG
((5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)p...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)C3CC3)n2)cn1
Show InChI InChI=1S/C19H24ClN7O/c1-26-10-15(6-22-26)24-19-21-7-16(20)17(25-19)23-14-4-12-8-27(9-13(12)5-14)18(28)11-2-3-11/h6-7,10-14H,2-5,8-9H2,1H3,(H2,21,23,24,25)
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US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387179
PNG
(5-chloro-N4-(2-((cyclopropylmethyl)sulfonyl)octahy...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)CC3CC3)n2)cn1
Show InChI InChI=1S/C19H26ClN7O2S/c1-26-10-16(6-22-26)24-19-21-7-17(20)18(25-19)23-15-4-13-8-27(9-14(13)5-15)30(28,29)11-12-2-3-12/h6-7,10,12-15H,2-5,8-9,11H2,1H3,(H2,21,23,24,25)
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US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387194
PNG
(5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C20H29ClN8O3S/c1-12(30)8-28-11-17(6-23-28)25-20-22-7-18(21)19(26-20)24-16-4-13-9-29(10-14(13)5-16)33(31,32)27-15-2-3-15/h6-7,11-16,27,30H,2-5,8-10H2,1H3,(H2,22,24,25,26)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387177
PNG
(US9938257, Example 15 | ethyl 5-((5-chloro-2-((1-m...)
Show SMILES CCOC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H24ClN7O2/c1-3-28-18(27)26-8-11-4-13(5-12(11)9-26)22-16-15(19)7-20-17(24-16)23-14-6-21-25(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H2,20,22,23,24)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387171
PNG
(3-(5-((5-chloro-2-((1-(pyridin-2-yl)-1H-pyrazol-4-...)
Show SMILES Clc1cnc(Nc2cnn(c2)-c2ccccn2)nc1NC1CC2CN(CC2C1)C(=O)CC#N
Show InChI InChI=1S/C22H22ClN9O/c23-18-10-26-22(29-17-9-27-32(13-17)19-3-1-2-6-25-19)30-21(18)28-16-7-14-11-31(12-15(14)8-16)20(33)4-5-24/h1-3,6,9-10,13-16H,4,7-8,11-12H2,(H2,26,28,29,30)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387181
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C19H25ClN8O/c1-27-10-15(6-22-27)24-18-21-7-16(20)17(26-18)23-14-4-11-8-28(9-12(11)5-14)19(29)25-13-2-3-13/h6-7,10-14H,2-5,8-9H2,1H3,(H,25,29)(H2,21,23,24,26)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387190
PNG
(5-((5-chloro-2-((1-(2-hydroxy-2-methylpropyl)-1H-p...)
Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C21H31ClN8O3S/c1-21(2,31)12-29-11-17(7-24-29)26-20-23-8-18(22)19(27-20)25-16-5-13-9-30(10-14(13)6-16)34(32,33)28-15-3-4-15/h7-8,11,13-16,28,31H,3-6,9-10,12H2,1-2H3,(H2,23,25,26,27)
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US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387193
PNG
(1-(4-((5-chloro-4-((2-((cyclopropylmethyl)sulfonyl...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)CC3CC3)n2)cn1
Show InChI InChI=1S/C21H30ClN7O3S/c1-13(30)8-28-11-18(6-24-28)26-21-23-7-19(22)20(27-21)25-17-4-15-9-29(10-16(15)5-17)33(31,32)12-14-2-3-14/h6-7,11,13-17,30H,2-5,8-10,12H2,1H3,(H2,23,25,26,27)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387169
PNG
(1-(5-((5-chloro-2-((1-(2-hydroxy-2-methylpropyl)-1...)
Show SMILES CC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(CC(C)(C)O)c2)ncc1Cl
Show InChI InChI=1S/C20H28ClN7O2/c1-12(29)27-8-13-4-15(5-14(13)9-27)24-18-17(21)7-22-19(26-18)25-16-6-23-28(10-16)11-20(2,3)30/h6-7,10,13-15,30H,4-5,8-9,11H2,1-3H3,(H2,22,24,25,26)
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US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387177
PNG
(US9938257, Example 15 | ethyl 5-((5-chloro-2-((1-m...)
Show SMILES CCOC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H24ClN7O2/c1-3-28-18(27)26-8-11-4-13(5-12(11)9-26)22-16-15(19)7-20-17(24-16)23-14-6-21-25(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H2,20,22,23,24)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387180
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H25ClN8O/c1-3-20-18(28)27-8-11-4-13(5-12(11)9-27)23-16-15(19)7-21-17(25-16)24-14-6-22-26(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H,20,28)(H2,21,23,24,25)
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CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387180
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H25ClN8O/c1-3-20-18(28)27-8-11-4-13(5-12(11)9-27)23-16-15(19)7-21-17(25-16)24-14-6-22-26(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H,20,28)(H2,21,23,24,25)
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n/an/a 12n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387188
PNG
(5-((5-chloro-2-((1-(pyrrolidin-3-yl)-1H-pyrazol-4-...)
Show SMILES Clc1cnc(Nc2cnn(c2)C2CCNC2)nc1NC1CC2CN(CC2C1)C(=O)NC1CC1
Show InChI InChI=1S/C22H30ClN9O/c23-19-9-25-21(28-17-7-26-32(12-17)18-3-4-24-8-18)30-20(19)27-16-5-13-10-31(11-14(13)6-16)22(33)29-15-1-2-15/h7,9,12-16,18,24H,1-6,8,10-11H2,(H,29,33)(H2,25,27,28,30)
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n/an/a 12n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387174
PNG
(1-(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)CC3CC3)n2)cn1
Show InChI InChI=1S/C20H26ClN7O/c1-27-11-16(7-23-27)25-20-22-8-17(21)19(26-20)24-15-5-13-9-28(10-14(13)6-15)18(29)4-12-2-3-12/h7-8,11-15H,2-6,9-10H2,1H3,(H2,22,24,25,26)
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n/an/a 12n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM387172
PNG
(3-(5-((5-chloro-2-((1-(6-methoxypyridin-3-yl)-1H-p...)
Show SMILES COc1ccc(cn1)-n1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)CC#N)n2)cn1
Show InChI InChI=1S/C23H24ClN9O2/c1-35-20-3-2-18(9-26-20)33-13-17(8-28-33)30-23-27-10-19(24)22(31-23)29-16-6-14-11-32(12-15(14)7-16)21(34)4-5-25/h2-3,8-10,13-16H,4,6-7,11-12H2,1H3,(H2,27,29,30,31)
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n/an/a 16n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
JAK2:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387174
PNG
(1-(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)CC3CC3)n2)cn1
Show InChI InChI=1S/C20H26ClN7O/c1-27-11-16(7-23-27)25-20-22-8-17(21)19(26-20)24-15-5-13-9-28(10-14(13)6-15)18(29)4-12-2-3-12/h7-8,11-15H,2-6,9-10H2,1H3,(H2,22,24,25,26)
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n/an/a 17n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387189
PNG
(5-((5-chloro-2-((1-(2-hydroxypropyl)-1H-pyrazol-4-...)
Show SMILES CC(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C21H29ClN8O2/c1-12(31)8-30-11-17(6-24-30)26-20-23-7-18(22)19(28-20)25-16-4-13-9-29(10-14(13)5-16)21(32)27-15-2-3-15/h6-7,11-16,31H,2-5,8-10H2,1H3,(H,27,32)(H2,23,25,26,28)
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n/an/a 19n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM387171
PNG
(3-(5-((5-chloro-2-((1-(pyridin-2-yl)-1H-pyrazol-4-...)
Show SMILES Clc1cnc(Nc2cnn(c2)-c2ccccn2)nc1NC1CC2CN(CC2C1)C(=O)CC#N
Show InChI InChI=1S/C22H22ClN9O/c23-18-10-26-22(29-17-9-27-32(13-17)19-3-1-2-6-25-19)30-21(18)28-16-7-14-11-31(12-15(14)8-16)20(33)4-5-24/h1-3,6,9-10,13-16H,4,7-8,11-12H2,(H2,26,28,29,30)
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n/an/a 20n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
JAK2:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387176
PNG
((5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)p...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)C3CC3)n2)cn1
Show InChI InChI=1S/C19H24ClN7O/c1-26-10-15(6-22-26)24-19-21-7-16(20)17(25-19)23-14-4-12-8-27(9-13(12)5-14)18(28)11-2-3-11/h6-7,10-14H,2-5,8-9H2,1H3,(H2,21,23,24,25)
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n/an/a 21n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387181
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)NC3CC3)n2)cn1
Show InChI InChI=1S/C19H25ClN8O/c1-27-10-15(6-22-27)24-18-21-7-16(20)17(26-18)23-14-4-11-8-28(9-12(11)5-14)19(29)25-13-2-3-13/h6-7,10-14H,2-5,8-9H2,1H3,(H,25,29)(H2,21,23,24,26)
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n/an/a 23n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387170
PNG
(3-(5-((5-chloro-2-((1-(2-hydroxy-2-methylpropyl)-1...)
Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)C(=O)CC#N)n2)cn1
Show InChI InChI=1S/C21H27ClN8O2/c1-21(2,32)12-30-11-16(7-25-30)27-20-24-8-17(22)19(28-20)26-15-5-13-9-29(10-14(13)6-15)18(31)3-4-23/h7-8,11,13-15,32H,3,5-6,9-10,12H2,1-2H3,(H2,24,26,27,28)
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n/an/a 28n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM387178
PNG
(1-(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC(C)(C)O)CC4C3)n2)cn1
Show InChI InChI=1S/C19H28ClN7O/c1-19(2,28)11-27-8-12-4-14(5-13(12)9-27)23-17-16(20)7-21-18(25-17)24-15-6-22-26(3)10-15/h6-7,10,12-14,28H,4-5,8-9,11H2,1-3H3,(H2,21,23,24,25)
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n/an/a 32n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
JAK1:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387183
PNG
(N4-(2-(tert-butylsulfonyl)octahydrocyclopenta[c]py...)
Show SMILES Cn1cc(Nc2ncc(Cl)c(NC3CC4CN(CC4C3)S(=O)(=O)C(C)(C)C)n2)cn1
Show InChI InChI=1S/C19H28ClN7O2S/c1-19(2,3)30(28,29)27-9-12-5-14(6-13(12)10-27)23-17-16(20)8-21-18(25-17)24-15-7-22-26(4)11-15/h7-8,11-14H,5-6,9-10H2,1-4H3,(H2,21,23,24,25)
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n/an/a 50n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387169
PNG
(1-(5-((5-chloro-2-((1-(2-hydroxy-2-methylpropyl)-1...)
Show SMILES CC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(CC(C)(C)O)c2)ncc1Cl
Show InChI InChI=1S/C20H28ClN7O2/c1-12(29)27-8-13-4-15(5-14(13)9-27)24-18-17(21)7-22-19(26-18)25-16-6-23-28(10-16)11-20(2,3)30/h6-7,10,13-15,30H,4-5,8-9,11H2,1-3H3,(H2,22,24,25,26)
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n/an/a 58n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Aurora kinase A


(Homo sapiens (Human))
BDBM387185
PNG
(1-(4-((5-chloro-4-((3-(methylsulfonyl)-3-azaspiro[...)
Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(CC4)S(C)(=O)=O)n2)cn1
Show InChI InChI=1S/C22H34ClN7O3S/c1-21(2,31)15-29-14-17(12-25-29)27-20-24-13-18(23)19(28-20)26-16-4-6-22(7-5-16)8-10-30(11-9-22)34(3,32)33/h12-14,16,31H,4-11,15H2,1-3H3,(H2,24,26,27,28)
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n/an/a 71n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
Aurora-A:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding w...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM387185
PNG
(1-(4-((5-chloro-4-((3-(methylsulfonyl)-3-azaspiro[...)
Show SMILES CC(C)(O)Cn1cc(Nc2ncc(Cl)c(NC3CCC4(CC3)CCN(CC4)S(C)(=O)=O)n2)cn1
Show InChI InChI=1S/C22H34ClN7O3S/c1-21(2,31)15-29-14-17(12-25-29)27-20-24-13-18(23)19(28-20)26-16-4-6-22(7-5-16)8-10-30(11-9-22)34(3,32)33/h12-14,16,31H,4-11,15H2,1-3H3,(H2,24,26,27,28)
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n/an/a 131n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
JAK2:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM387177
PNG
(US9938257, Example 15 | ethyl 5-((5-chloro-2-((1-m...)
Show SMILES CCOC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H24ClN7O2/c1-3-28-18(27)26-8-11-4-13(5-12(11)9-26)22-16-15(19)7-20-17(24-16)23-14-6-21-25(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H2,20,22,23,24)
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n/an/a 136n/an/an/an/an/an/a



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US Patent


Assay Description
JAK2:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM387180
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H25ClN8O/c1-3-20-18(28)27-8-11-4-13(5-12(11)9-27)23-16-15(19)7-21-17(25-16)24-14-6-22-26(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H,20,28)(H2,21,23,24,25)
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n/an/a 142n/an/an/an/an/an/a



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US Patent


Assay Description
JAK2:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM387177
PNG
(US9938257, Example 15 | ethyl 5-((5-chloro-2-((1-m...)
Show SMILES CCOC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H24ClN7O2/c1-3-28-18(27)26-8-11-4-13(5-12(11)9-26)22-16-15(19)7-20-17(24-16)23-14-6-21-25(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H2,20,22,23,24)
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n/an/a 503n/an/an/an/an/an/a



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US Patent


Assay Description
FLT3:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM387180
PNG
(5-((5-chloro-2-((1-methyl-1H-pyrazol-4-yl)amino)py...)
Show SMILES CCNC(=O)N1CC2CC(CC2C1)Nc1nc(Nc2cnn(C)c2)ncc1Cl
Show InChI InChI=1S/C18H25ClN8O/c1-3-20-18(28)27-8-11-4-13(5-12(11)9-27)23-16-15(19)7-21-17(25-16)24-14-6-22-26(2)10-14/h6-7,10-13H,3-5,8-9H2,1-2H3,(H,20,28)(H2,21,23,24,25)
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n/an/a 1.03E+3n/an/an/an/an/an/a



CALITOR SCIENCES, LLC; SUNSHINE LAKE PHARMA CO., LTD.

US Patent


Assay Description
FLT3:Kinase assays can be performed by measurement of incorporation of γ-33P ATP into immobilized myelin basic protein (MBP). High binding white...


US Patent US9938257 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%