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Patent code US9938265

Compile Data Set for Download or QSAR
Found 43 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387023
PNG
((2S)-N-[5-[[(3R)-1-(5-chloropyridazin-3-yl)pyrroli...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(Cl)cnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C20H22ClN7O3S/c1-30-15-5-3-12(4-6-15)17(31-2)18(29)24-20-27-26-19(32-20)23-14-7-8-28(11-14)16-9-13(21)10-22-25-16/h3-6,9-10,14,17H,7-8,11H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,17+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 15.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387034
PNG
(N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C20H22FN7O3S/c1-30-14-5-3-12(4-6-14)17(31-2)18(29)23-20-27-26-19(32-20)22-13-9-10-28(11-13)16-8-7-15(21)24-25-16/h3-8,13,17H,9-11H2,1-2H3,(H,22,26)(H,23,27,29)/t13-,17?/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 18.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387019
PNG
((2S)-2-[3-(difluoromethoxy)phenyl]-N-[5-[[(3R)-1-(...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C20H20F3N7O3S/c1-32-16(11-3-2-4-13(9-11)33-18(22)23)17(31)25-20-29-28-19(34-20)24-12-7-8-30(10-12)15-6-5-14(21)26-27-15/h2-6,9,12,16,18H,7-8,10H2,1H3,(H,24,28)(H,25,29,31)/t12-,16+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 22.7n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387030
PNG
(N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H19F4N7O3S/c1-33-16(11-3-2-4-13(9-11)34-20(22,23)24)17(32)26-19-30-29-18(35-19)25-12-7-8-31(10-12)15-6-5-14(21)27-28-15/h2-6,9,12,16H,7-8,10H2,1H3,(H,25,29)(H,26,30,32)/t12-,16?/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 24.3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387007
PNG
((2S)-N-[5-[[(3R)-1-(6-Fluoropyridazin-3-yl)pyrroli...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1ccccc1
Show InChI InChI=1S/C19H20FN7O2S/c1-29-16(12-5-3-2-4-6-12)17(28)22-19-26-25-18(30-19)21-13-9-10-27(11-13)15-8-7-14(20)23-24-15/h2-8,13,16H,9-11H2,1H3,(H,21,25)(H,22,26,28)/t13-,16+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 30.3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387021
PNG
((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-(5...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(C)cnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN7O2S/c1-12-9-16(25-22-10-12)28-8-7-15(11-28)23-19-26-27-20(31-19)24-18(29)17(30-2)13-3-5-14(21)6-4-13/h3-6,9-10,15,17H,7-8,11H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,17+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 31.1n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387045
PNG
((2S)-N-[5-[[(3R)-1-(5-chloropyridazin-3-yl)pyrroli...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(Cl)cnn2)s1)c1ccccc1
Show InChI InChI=1S/C19H20ClN7O2S/c1-29-16(12-5-3-2-4-6-12)17(28)23-19-26-25-18(30-19)22-14-7-8-27(11-14)15-9-13(20)10-21-24-15/h2-6,9-10,14,16H,7-8,11H2,1H3,(H,22,25)(H,23,26,28)/t14-,16+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 35.3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387025
PNG
((2S)-N-[5-[[(3R)-1-(5-Chloropyridazin-3-yl)pyrroli...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(Cl)cnn2)s1)c1ccccc1
Show InChI InChI=1S/C19H20ClN7O2S/c1-29-16(12-5-3-2-4-6-12)17(28)23-19-26-25-18(30-19)22-14-7-8-27(11-14)15-9-13(20)10-21-24-15/h2-6,9-10,14,16H,7-8,11H2,1H3,(H,22,25)(H,23,26,28)/t14-,16+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 35.3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387008
PNG
((2S)-N-[5-[[(3R)-1-(6-Fluoropyridazin-3-yl)pyrroli...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C20H22FN7O3S/c1-30-14-5-3-4-12(10-14)17(31-2)18(29)23-20-27-26-19(32-20)22-13-8-9-28(11-13)16-7-6-15(21)24-25-16/h3-7,10,13,17H,8-9,11H2,1-2H3,(H,22,26)(H,23,27,29)/t13-,17+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 38.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387027
PNG
((2S)-2-methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccccc1
Show InChI InChI=1S/C20H23N7O2S/c1-13-8-9-16(24-23-13)27-11-10-15(12-27)21-19-25-26-20(30-19)22-18(28)17(29-2)14-6-4-3-5-7-14/h3-9,15,17H,10-12H2,1-2H3,(H,21,25)(H,22,26,28)/t15-,17+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 44.3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387005
PNG
((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C21H25N7O3S/c1-13-7-8-17(25-24-13)28-10-9-15(12-28)22-20-26-27-21(32-20)23-19(29)18(31-3)14-5-4-6-16(11-14)30-2/h4-8,11,15,18H,9-10,12H2,1-3H3,(H,22,26)(H,23,27,29)/t15-,18+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 55.4n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387032
PNG
(2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-fluoropyridazi...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C19H19F2N7O2S/c1-30-16(11-2-4-12(20)5-3-11)17(29)23-19-27-26-18(31-19)22-13-8-9-28(10-13)15-7-6-14(21)24-25-15/h2-7,13,16H,8-10H2,1H3,(H,22,26)(H,23,27,29)/t13-,16?/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 55.7n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387044
PNG
((2S)-2-methoxy-N-[5-[[(3R)-1-(5-methylpyridazin-3-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(C)cnn2)s1)c1ccccc1
Show InChI InChI=1S/C20H23N7O2S/c1-13-10-16(24-21-11-13)27-9-8-15(12-27)22-19-25-26-20(30-19)23-18(28)17(29-2)14-6-4-3-5-7-14/h3-7,10-11,15,17H,8-9,12H2,1-2H3,(H,22,25)(H,23,26,28)/t15-,17+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 59.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387026
PNG
((2S)-2-Methoxy-N-[5-[[(3R)-1-(5-methylpyridazin-3-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(C)cnn2)s1)c1ccccc1
Show InChI InChI=1S/C20H23N7O2S/c1-13-10-16(24-21-11-13)27-9-8-15(12-27)22-19-25-26-20(30-19)23-18(28)17(29-2)14-6-4-3-5-7-14/h3-7,10-11,15,17H,8-9,12H2,1-2H3,(H,22,25)(H,23,26,28)/t15-,17+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 59.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387030
PNG
(N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C20H19F4N7O3S/c1-33-16(11-3-2-4-13(9-11)34-20(22,23)24)17(32)26-19-30-29-18(35-19)25-12-7-8-31(10-12)15-6-5-14(21)27-28-15/h2-6,9,12,16H,7-8,10H2,1H3,(H,25,29)(H,26,30,32)/t12-,16?/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 65.3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387036
PNG
(2-(4-fluoro-3-methoxy-phenyl)-N-[5-[[(3R)-1-(6-flu...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C20H21F2N7O3S/c1-31-14-9-11(3-4-13(14)21)17(32-2)18(30)24-20-28-27-19(33-20)23-12-7-8-29(10-12)16-6-5-15(22)25-26-16/h3-6,9,12,17H,7-8,10H2,1-2H3,(H,23,27)(H,24,28,30)/t12-,17?/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 71.3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387009
PNG
((2S)-2-Ethoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(6...)
Show SMILES CCO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C22H27N7O3S/c1-4-32-19(15-6-5-7-17(12-15)31-3)20(30)24-22-28-27-21(33-22)23-16-10-11-29(13-16)18-9-8-14(2)25-26-18/h5-9,12,16,19H,4,10-11,13H2,1-3H3,(H,23,27)(H,24,28,30)/t16-,19+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 79.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387046
PNG
((2R)-2-methoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(C)cnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C21H25N7O3S/c1-13-10-17(25-22-11-13)28-9-8-15(12-28)23-20-26-27-21(32-20)24-19(29)18(31-3)14-4-6-16(30-2)7-5-14/h4-7,10-11,15,18H,8-9,12H2,1-3H3,(H,23,26)(H,24,27,29)/t15-,18+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 79.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387028
PNG
(2-ethoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(6-meth...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C22H27N7O3S/c1-4-32-19(15-6-8-17(31-3)9-7-15)20(30)24-22-28-27-21(33-22)23-16-11-12-29(13-16)18-10-5-14(2)25-26-18/h5-10,16,19H,4,11-13H2,1-3H3,(H,23,27)(H,24,28,30)/t16-,19?/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 80.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387013
PNG
((2S)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C21H24FN7O3S/c1-12-4-7-17(26-25-12)29-9-8-14(11-29)23-20-27-28-21(33-20)24-19(30)18(32-3)13-5-6-15(22)16(10-13)31-2/h4-7,10,14,18H,8-9,11H2,1-3H3,(H,23,27)(H,24,28,30)/t14-,18+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 82.7n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387024
PNG
((2S)-N-[5-[[(3R)-1-(5-chloropyridazin-3-yl)pyrroli...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(Cl)cnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C20H22ClN7O3S/c1-30-15-5-3-12(4-6-15)17(31-2)18(29)24-20-27-26-19(32-20)23-14-7-8-28(11-14)16-9-13(21)10-22-25-16/h3-6,9-10,14,17H,7-8,11H2,1-2H3,(H,23,26)(H,24,27,29)/t14-,17-/m1/s1
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n/an/a 84.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387038
PNG
(2-ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-fluor...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C20H21F2N7O2S/c1-2-31-17(12-3-5-13(21)6-4-12)18(30)24-20-28-27-19(32-20)23-14-9-10-29(11-14)16-8-7-15(22)25-26-16/h3-8,14,17H,2,9-11H2,1H3,(H,23,27)(H,24,28,30)/t14-,17?/m1/s1
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UniChem
US Patent
n/an/a 94.8n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387015
PNG
((2S)-2-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H22F3N7O3S/c1-12-6-7-16(28-27-12)31-9-8-14(11-31)25-19-29-30-20(35-19)26-18(32)17(33-2)13-4-3-5-15(10-13)34-21(22,23)24/h3-7,10,14,17H,8-9,11H2,1-2H3,(H,25,29)(H,26,30,32)/t14-,17+/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 95.2n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387040
PNG
(2-ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-methy...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN7O2S/c1-3-31-18(14-5-7-15(22)8-6-14)19(30)24-21-28-27-20(32-21)23-16-10-11-29(12-16)17-9-4-13(2)25-26-17/h4-9,16,18H,3,10-12H2,1-2H3,(H,23,27)(H,24,28,30)/t16-,18?/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 96n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387020
PNG
((2S)-2-[3-(difluoromethoxy)phenyl]-N-[5-[[(3R)-1-(...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C20H20F3N7O3S/c1-32-16(11-3-2-4-13(9-11)33-18(22)23)17(31)25-20-29-28-19(34-20)24-12-7-8-30(10-12)15-6-5-14(21)26-27-15/h2-6,9,12,16,18H,7-8,10H2,1H3,(H,24,28)(H,25,29,31)/t12-,16-/m1/s1
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UniChem
US Patent
n/an/a 98.9n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387017
PNG
((2S)-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-[[...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C21H23F2N7O3S/c1-12-6-7-16(27-26-12)30-9-8-14(11-30)24-20-28-29-21(34-20)25-18(31)17(32-2)13-4-3-5-15(10-13)33-19(22)23/h3-7,10,14,17,19H,8-9,11H2,1-2H3,(H,24,28)(H,25,29,31)/t14-,17+/m1/s1
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UniChem
US Patent
n/an/a 99.4n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387042
PNG
(2-methoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(6-met...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C21H25N7O3S/c1-13-4-9-17(25-24-13)28-11-10-15(12-28)22-20-26-27-21(32-20)23-19(29)18(31-3)14-5-7-16(30-2)8-6-14/h4-9,15,18H,10-12H2,1-3H3,(H,22,26)(H,23,27,29)/t15-,18?/m1/s1
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US Patent
n/an/a 119n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387046
PNG
((2R)-2-methoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(C)cnn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C21H25N7O3S/c1-13-10-17(25-22-11-13)28-9-8-15(12-28)23-20-26-27-21(32-20)24-19(29)18(31-3)14-4-6-16(30-2)7-5-14/h4-7,10-11,15,18H,8-9,12H2,1-3H3,(H,23,26)(H,24,27,29)/t15-,18+/m1/s1
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US Patent
n/an/a 148n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387011
PNG
((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-(6...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN7O2S/c1-12-3-8-16(25-24-12)28-10-9-15(11-28)22-19-26-27-20(31-19)23-18(29)17(30-2)13-4-6-14(21)7-5-13/h3-8,15,17H,9-11H2,1-2H3,(H,22,26)(H,23,27,29)/t15-,17+/m1/s1
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US Patent
n/an/a 155n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387034
PNG
(N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C20H22FN7O3S/c1-30-14-5-3-12(4-6-14)17(31-2)18(29)23-20-27-26-19(32-20)22-13-9-10-28(11-13)16-8-7-15(21)24-25-16/h3-8,13,17H,9-11H2,1-2H3,(H,22,26)(H,23,27,29)/t13-,17?/m1/s1
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US Patent
n/an/a 223n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387022
PNG
((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-(5...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2cc(C)cnn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN7O2S/c1-12-9-16(25-22-10-12)28-8-7-15(11-28)23-19-26-27-20(31-19)24-18(29)17(30-2)13-3-5-14(21)6-4-13/h3-6,9-10,15,17H,7-8,11H2,1-2H3,(H,23,26)(H,24,27,29)/t15-,17-/m1/s1
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US Patent
n/an/a 241n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387036
PNG
(2-(4-fluoro-3-methoxy-phenyl)-N-[5-[[(3R)-1-(6-flu...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C20H21F2N7O3S/c1-31-14-9-11(3-4-13(14)21)17(32-2)18(30)24-20-28-27-19(33-20)23-12-7-8-29(10-12)16-6-5-15(22)25-26-16/h3-6,9,12,17H,7-8,10H2,1-2H3,(H,23,27)(H,24,28,30)/t12-,17?/m1/s1
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UniChem
US Patent
n/an/a 265n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387028
PNG
(2-ethoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(6-meth...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C22H27N7O3S/c1-4-32-19(15-6-8-17(31-3)9-7-15)20(30)24-22-28-27-21(33-22)23-16-11-12-29(13-16)18-10-5-14(2)25-26-18/h5-10,16,19H,4,11-13H2,1-3H3,(H,23,27)(H,24,28,30)/t16-,19?/m1/s1
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US Patent
n/an/a 277n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387010
PNG
((2S)-2-Ethoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(6...)
Show SMILES CCO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C22H27N7O3S/c1-4-32-19(15-6-5-7-17(12-15)31-3)20(30)24-22-28-27-21(33-22)23-16-10-11-29(13-16)18-9-8-14(2)25-26-18/h5-9,12,16,19H,4,10-11,13H2,1-3H3,(H,23,27)(H,24,28,30)/t16-,19-/m1/s1
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US Patent
n/an/a 290n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387032
PNG
(2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-fluoropyridazi...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C19H19F2N7O2S/c1-30-16(11-2-4-12(20)5-3-11)17(29)23-19-27-26-18(31-19)22-13-8-9-28(10-13)15-7-6-14(21)24-25-15/h2-7,13,16H,8-10H2,1H3,(H,22,26)(H,23,27,29)/t13-,16?/m1/s1
GoogleScholar
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US Patent
n/an/a 323n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387016
PNG
((2S)-2-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C21H22F3N7O3S/c1-12-6-7-16(28-27-12)31-9-8-14(11-31)25-19-29-30-20(35-19)26-18(32)17(33-2)13-4-3-5-15(10-13)34-21(22,23)24/h3-7,10,14,17H,8-9,11H2,1-2H3,(H,25,29)(H,26,30,32)/t14-,17-/m1/s1
GoogleScholar
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US Patent
n/an/a 334n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387006
PNG
((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(OC)c1
Show InChI InChI=1S/C21H25N7O3S/c1-13-7-8-17(25-24-13)28-10-9-15(12-28)22-20-26-27-21(32-20)23-19(29)18(31-3)14-5-4-6-16(11-14)30-2/h4-8,11,15,18H,9-10,12H2,1-3H3,(H,22,26)(H,23,27,29)/t15-,18-/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 406n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387017
PNG
((2S)-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-[[...)
Show SMILES CO[C@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1cccc(OC(F)F)c1
Show InChI InChI=1S/C21H23F2N7O3S/c1-12-6-7-16(27-26-12)30-9-8-14(11-30)24-20-28-29-21(34-20)25-18(31)17(32-2)13-4-3-5-15(10-13)33-19(22)23/h3-7,10,14,17,19H,8-9,11H2,1-2H3,(H,24,28)(H,25,29,31)/t14-,17+/m1/s1
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US Patent
n/an/a 643n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387012
PNG
((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-(6...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C20H22FN7O2S/c1-12-3-8-16(25-24-12)28-10-9-15(11-28)22-19-26-27-20(31-19)23-18(29)17(30-2)13-4-6-14(21)7-5-13/h3-8,15,17H,9-11H2,1-2H3,(H,22,26)(H,23,27,29)/t15-,17-/m1/s1
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US Patent
n/an/a 975n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387038
PNG
(2-ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-fluor...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(F)nn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C20H21F2N7O2S/c1-2-31-17(12-3-5-13(21)6-4-12)18(30)24-20-28-27-19(32-20)23-14-9-10-29(11-14)16-8-7-15(22)25-26-16/h3-8,14,17H,2,9-11H2,1H3,(H,23,27)(H,24,28,30)/t14-,17?/m1/s1
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US Patent
n/an/a 1.09E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387042
PNG
(2-methoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(6-met...)
Show SMILES COC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccc(OC)cc1
Show InChI InChI=1S/C21H25N7O3S/c1-13-4-9-17(25-24-13)28-11-10-15(12-28)22-20-26-27-21(32-20)23-19(29)18(31-3)14-5-7-16(30-2)8-6-14/h4-9,15,18H,10-12H2,1-3H3,(H,22,26)(H,23,27,29)/t15-,18?/m1/s1
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n/an/a 1.28E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387040
PNG
(2-ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-methy...)
Show SMILES CCOC(C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccc(F)cc1
Show InChI InChI=1S/C21H24FN7O2S/c1-3-31-18(14-5-7-15(22)8-6-14)19(30)24-21-28-27-20(32-21)23-16-10-11-29(12-16)17-9-4-13(2)25-26-17/h4-9,16,18H,3,10-12H2,1-2H3,(H,23,27)(H,24,28,30)/t16-,18?/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 2.38E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
GLS (aa 63-669)


(Homo sapiens (Human))
BDBM387014
PNG
((2S)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...)
Show SMILES CO[C@@H](C(=O)Nc1nnc(N[C@@H]2CCN(C2)c2ccc(C)nn2)s1)c1ccc(F)c(OC)c1
Show InChI InChI=1S/C21H24FN7O3S/c1-12-4-7-17(26-25-12)29-9-8-14(11-29)23-20-27-28-21(33-20)24-19(30)18(32-3)13-5-6-15(22)16(10-13)31-2/h4-7,10,14,18H,8-9,11H2,1-3H3,(H,23,27)(H,24,28,30)/t14-,18-/m1/s1
GoogleScholar
UniChem
US Patent
n/an/a 2.53E+3n/an/an/an/an/an/a



AstraZeneca AB; Cancer Research Technology Limited

US Patent


Assay Description
A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...


US Patent US9938265 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%