Compile Data Set for Download or QSAR
maximum 50k data
Found 43 Enz. Inhib. hit(s) with all data for entry = 2960
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387023((2S)-N-[5-[[(3R)-1-(5-chloropyridazin-3-yl)pyrroli...)
Affinity DataIC50:  15.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387034(N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3...)
Affinity DataIC50:  18.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387019((2S)-2-[3-(difluoromethoxy)phenyl]-N-[5-[[(3R)-1-(...)
Affinity DataIC50:  22.7nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387030(N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3...)
Affinity DataIC50:  24.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387007((2S)-N-[5-[[(3R)-1-(6-Fluoropyridazin-3-yl)pyrroli...)
Affinity DataIC50:  30.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387021((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-(5...)
Affinity DataIC50:  31.1nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387025((2S)-N-[5-[[(3R)-1-(5-Chloropyridazin-3-yl)pyrroli...)
Affinity DataIC50:  35.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387045((2S)-N-[5-[[(3R)-1-(5-chloropyridazin-3-yl)pyrroli...)
Affinity DataIC50:  35.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387008((2S)-N-[5-[[(3R)-1-(6-Fluoropyridazin-3-yl)pyrroli...)
Affinity DataIC50:  38.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387027((2S)-2-methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...)
Affinity DataIC50:  44.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387005((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Affinity DataIC50:  55.4nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387032(2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-fluoropyridazi...)
Affinity DataIC50:  55.7nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387044((2S)-2-methoxy-N-[5-[[(3R)-1-(5-methylpyridazin-3-...)
Affinity DataIC50:  59.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387026((2S)-2-Methoxy-N-[5-[[(3R)-1-(5-methylpyridazin-3-...)
Affinity DataIC50:  59.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387030(N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3...)
Affinity DataIC50:  65.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387036(2-(4-fluoro-3-methoxy-phenyl)-N-[5-[[(3R)-1-(6-flu...)
Affinity DataIC50:  71.3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387009((2S)-2-Ethoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(6...)
Affinity DataIC50:  79.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387046((2R)-2-methoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Affinity DataIC50:  79.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387028(2-ethoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(6-meth...)
Affinity DataIC50:  80.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387013((2S)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...)
Affinity DataIC50:  82.7nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387024((2S)-N-[5-[[(3R)-1-(5-chloropyridazin-3-yl)pyrroli...)
Affinity DataIC50:  84.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387038(2-ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-fluor...)
Affinity DataIC50:  94.8nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387015((2S)-2-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...)
Affinity DataIC50:  95.2nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387040(2-ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-methy...)
Affinity DataIC50:  96nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387020((2S)-2-[3-(difluoromethoxy)phenyl]-N-[5-[[(3R)-1-(...)
Affinity DataIC50:  98.9nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387017((2S)-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-[[...)
Affinity DataIC50:  99.4nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387042(2-methoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(6-met...)
Affinity DataIC50:  119nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387046((2R)-2-methoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Affinity DataIC50:  148nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387011((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-(6...)
Affinity DataIC50:  155nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387034(N-[5-[[(3R)-1-(6-fluoropyridazin-3-yl)pyrrolidin-3...)
Affinity DataIC50:  223nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387022((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-(5...)
Affinity DataIC50:  241nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387036(2-(4-fluoro-3-methoxy-phenyl)-N-[5-[[(3R)-1-(6-flu...)
Affinity DataIC50:  265nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387028(2-ethoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(6-meth...)
Affinity DataIC50:  277nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387010((2S)-2-Ethoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(6...)
Affinity DataIC50:  290nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387032(2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-fluoropyridazi...)
Affinity DataIC50:  323nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387016((2S)-2-Methoxy-N-[5-[[(3R)-1-(6-methylpyridazin-3-...)
Affinity DataIC50:  334nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387006((2S)-2-Methoxy-2-(3-methoxyphenyl)-N-[5-[[(3R)-1-(...)
Affinity DataIC50:  406nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387017((2S)-[3-(Difluoromethoxy)phenyl]-2-methoxy-N-[5-[[...)
Affinity DataIC50:  643nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387012((2S)-2-(4-Fluorophenyl)-2-methoxy-N-[5-[[(3R)-1-(6...)
Affinity DataIC50:  975nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387038(2-ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-fluor...)
Affinity DataIC50:  1.09E+3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387042(2-methoxy-2-(4-methoxyphenyl)-N-[5-[[(3R)-1-(6-met...)
Affinity DataIC50:  1.28E+3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387040(2-ethoxy-2-(4-fluorophenyl)-N-[5-[[(3R)-1-(6-methy...)
Affinity DataIC50:  2.38E+3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetGlutaminase kidney isoform, mitochondrial [63-669](Homo sapiens (Human))
Astrazeneca

US Patent
LigandPNGBDBM387014((2S)-2-(4-Fluoro-3-methoxy-phenyl)-2-methoxy-N-[5-...)
Affinity DataIC50:  2.53E+3nMAssay Description:A Glutamate Oxidase/AmplexRed coupled assay was used to measure the ability of compounds to bind to and inhibit the activity of GLS1 in vitro. 6His t...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent