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Patent code US9938272

Compile Data Set for Download or QSAR
Found 109 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Coagulation factor X


(Homo sapiens (Human))
BDBM387054
PNG
(1-(4-Methoxyphenyl)-6-(1-(2-oxopyrrolidin-1-yl)pip...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O3/c1-34-17-6-4-16(5-7-17)31-20-18(21(27-31)23(24,25)26)10-14-29(22(20)33)15-8-12-28(13-9-15)30-11-2-3-19(30)32/h4-7,15H,2-3,8-14H2,1H3
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<10n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387054
PNG
(1-(4-Methoxyphenyl)-6-(1-(2-oxopyrrolidin-1-yl)pip...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O3/c1-34-17-6-4-16(5-7-17)31-20-18(21(27-31)23(24,25)26)10-14-29(22(20)33)15-8-12-28(13-9-15)30-11-2-3-19(30)32/h4-7,15H,2-3,8-14H2,1H3
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<10n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387058
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(1-(3-oxomorpholino)pi...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O5/c1-33-17-4-2-16(3-5-17)29-21-18(20(25-29)22(24)31)8-11-27(23(21)32)15-6-9-26(10-7-15)28-12-13-34-14-19(28)30/h2-5,15H,6-14H2,1H3,(H2,24,31)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387059
PNG
(US9938272, Example 8a | US9938272, Example 8b)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)C3CCNC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O4/c1-33-16-4-2-15(3-5-16)29-20-17(19(26-29)21(24)30)9-13-28(23(20)32)14-7-11-27(12-8-14)18-6-10-25-22(18)31/h2-5,14,18H,6-13H2,1H3,(H2,24,30)(H,25,31)
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<10n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387068
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2-oxo-[1,4′-bip...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(N3CCC(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-29(24(22)33)27-13-9-16(10-14-27)28-12-3-2-4-20(28)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387077
PNG
(4-(4-(1-(4-(Difluoromethoxy)phenyl)-7-oxo-3-(trifl...)
Show SMILES FC(F)Oc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F5N5O4/c24-22(25)37-16-3-1-15(2-4-16)33-19-17(20(29-33)23(26,27)28)7-10-31(21(19)35)14-5-8-30(9-6-14)32-11-12-36-13-18(32)34/h1-4,14,22H,5-13H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387078
PNG
(4-(4-(1-(6-Chloronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES FC(F)(F)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc2cc(Cl)ccc2c1
Show InChI InChI=1S/C26H25ClF3N5O3/c27-18-3-1-17-14-20(4-2-16(17)13-18)35-23-21(24(31-35)26(28,29)30)7-10-33(25(23)37)19-5-8-32(9-6-19)34-11-12-38-15-22(34)36/h1-4,13-14,19H,5-12,15H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387083
PNG
(4-(4-(1-(3-Fluoronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES Fc1cc2ccccc2cc1-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C26H25F4N5O3/c27-20-13-16-3-1-2-4-17(16)14-21(20)35-23-19(24(31-35)26(28,29)30)7-10-33(25(23)37)18-5-8-32(9-6-18)34-11-12-38-15-22(34)36/h1-4,13-14,18H,5-12,15H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387049
PNG
(4-(4-(1-(4-Methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O4/c1-34-17-4-2-16(3-5-17)31-20-18(21(27-31)23(24,25)26)8-11-29(22(20)33)15-6-9-28(10-7-15)30-12-13-35-14-19(30)32/h2-5,15H,6-14H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387065
PNG
(1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C23H26F2N6O5/c24-23(25)36-16-3-1-15(2-4-16)31-20-17(19(27-31)21(26)33)7-10-29(22(20)34)14-5-8-28(9-6-14)30-11-12-35-13-18(30)32/h1-4,14,23H,5-13H2,(H2,26,33)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387078
PNG
(4-(4-(1-(6-Chloronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES FC(F)(F)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc2cc(Cl)ccc2c1
Show InChI InChI=1S/C26H25ClF3N5O3/c27-18-3-1-17-14-20(4-2-16(17)13-18)35-23-21(24(31-35)26(28,29)30)7-10-33(25(23)37)19-5-8-32(9-6-19)34-11-12-38-15-22(34)36/h1-4,13-14,19H,5-12,15H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387083
PNG
(4-(4-(1-(3-Fluoronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES Fc1cc2ccccc2cc1-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C26H25F4N5O3/c27-20-13-16-3-1-2-4-17(16)14-21(20)35-23-19(24(31-35)26(28,29)30)7-10-33(25(23)37)18-5-8-32(9-6-18)34-11-12-38-15-22(34)36/h1-4,13-14,18H,5-12,15H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387049
PNG
(4-(4-(1-(4-Methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O4/c1-34-17-4-2-16(3-5-17)31-20-18(21(27-31)23(24,25)26)8-11-29(22(20)33)15-6-9-28(10-7-15)30-12-13-35-14-19(30)32/h2-5,15H,6-14H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387057
PNG
(N′-Cyano-1-(4-methoxyphenyl)-7-oxo-6-(2̸...)
Show SMILES COc1ccc(cc1)-n1nc(\C(N)=N/C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C25H30N8O3/c1-36-19-7-5-18(6-8-19)33-23-20(22(29-33)24(27)28-16-26)11-15-31(25(23)35)17-9-13-30(14-10-17)32-12-3-2-4-21(32)34/h5-8,17H,2-4,9-15H2,1H3,(H2,27,28)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387057
PNG
(N′-Cyano-1-(4-methoxyphenyl)-7-oxo-6-(2̸...)
Show SMILES COc1ccc(cc1)-n1nc(\C(N)=N/C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C25H30N8O3/c1-36-19-7-5-18(6-8-19)33-23-20(22(29-33)24(27)28-16-26)11-15-31(25(23)35)17-9-13-30(14-10-17)32-12-3-2-4-21(32)34/h5-8,17H,2-4,9-15H2,1H3,(H2,27,28)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387064
PNG
(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-1-(4-(...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N6O5/c24-23(25,26)37-16-3-1-15(2-4-16)32-20-17(19(28-32)21(27)34)7-10-30(22(20)35)14-5-8-29(9-6-14)31-11-12-36-13-18(31)33/h1-4,14H,5-13H2,(H2,27,34)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387078
PNG
(4-(4-(1-(6-Chloronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES FC(F)(F)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc2cc(Cl)ccc2c1
Show InChI InChI=1S/C26H25ClF3N5O3/c27-18-3-1-17-14-20(4-2-16(17)13-18)35-23-21(24(31-35)26(28,29)30)7-10-33(25(23)37)19-5-8-32(9-6-19)34-11-12-38-15-22(34)36/h1-4,13-14,19H,5-12,15H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387080
PNG
(4-(4-(1-(3-Aminobenzo[d]isoxazol-5-yl)-7-oxo-3-(tr...)
Show SMILES Nc1noc2ccc(cc12)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F3N7O4/c24-23(25,26)20-15-5-8-31(13-3-6-30(7-4-13)32-9-10-36-12-18(32)34)22(35)19(15)33(28-20)14-1-2-17-16(11-14)21(27)29-37-17/h1-2,11,13H,3-10,12H2,(H2,27,29)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387082
PNG
(4-(4-(1-(3-Fluoro-4-methoxyphenyl)-7-oxo-3-(triflu...)
Show SMILES COc1ccc(cc1F)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F4N5O4/c1-35-18-3-2-15(12-17(18)24)32-20-16(21(28-32)23(25,26)27)6-9-30(22(20)34)14-4-7-29(8-5-14)31-10-11-36-13-19(31)33/h2-3,12,14H,4-11,13H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387049
PNG
(4-(4-(1-(4-Methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O4/c1-34-17-4-2-16(3-5-17)31-20-18(21(27-31)23(24,25)26)8-11-29(22(20)33)15-6-9-28(10-7-15)30-12-13-35-14-19(30)32/h2-5,15H,6-14H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387050
PNG
(1-(4-Methoxyphenyl)-6-(2′-oxo-[1,1′-bi...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O3/c1-35-18-7-5-17(6-8-18)32-21-19(22(28-32)24(25,26)27)11-15-30(23(21)34)16-9-13-29(14-10-16)31-12-3-2-4-20(31)33/h5-8,16H,2-4,9-15H2,1H3
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<10n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387068
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2-oxo-[1,4′-bip...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(N3CCC(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-29(24(22)33)27-13-9-16(10-14-27)28-12-3-2-4-20(28)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387082
PNG
(4-(4-(1-(3-Fluoro-4-methoxyphenyl)-7-oxo-3-(triflu...)
Show SMILES COc1ccc(cc1F)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F4N5O4/c1-35-18-3-2-15(12-17(18)24)32-20-16(21(28-32)23(25,26)27)6-9-30(22(20)34)14-4-7-29(8-5-14)31-10-11-36-13-19(31)33/h2-3,12,14H,4-11,13H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM19023
PNG
(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O
Show InChI InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
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<10n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387056
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H28N6O3/c1-33-19-7-5-18(6-8-19)30-23-20(21(16-25)26-30)11-15-28(24(23)32)17-9-13-27(14-10-17)29-12-3-2-4-22(29)31/h5-8,17H,2-4,9-15H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387054
PNG
(1-(4-Methoxyphenyl)-6-(1-(2-oxopyrrolidin-1-yl)pip...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O3/c1-34-17-6-4-16(5-7-17)31-20-18(21(27-31)23(24,25)26)10-14-29(22(20)33)15-8-12-28(13-9-15)30-11-2-3-19(30)32/h4-7,15H,2-3,8-14H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387055
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-28(24(22)33)16-9-13-27(14-10-16)29-12-3-2-4-20(29)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387065
PNG
(1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C23H26F2N6O5/c24-23(25)36-16-3-1-15(2-4-16)31-20-17(19(27-31)21(26)33)7-10-29(22(20)34)14-5-8-28(9-6-14)30-11-12-35-13-18(30)32/h1-4,14,23H,5-13H2,(H2,26,33)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387077
PNG
(4-(4-(1-(4-(Difluoromethoxy)phenyl)-7-oxo-3-(trifl...)
Show SMILES FC(F)Oc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F5N5O4/c24-22(25)37-16-3-1-15(2-4-16)33-19-17(20(29-33)23(26,27)28)7-10-31(21(19)35)14-5-8-30(9-6-14)32-11-12-36-13-18(32)34/h1-4,14,22H,5-13H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387055
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-28(24(22)33)16-9-13-27(14-10-16)29-12-3-2-4-20(29)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387080
PNG
(4-(4-(1-(3-Aminobenzo[d]isoxazol-5-yl)-7-oxo-3-(tr...)
Show SMILES Nc1noc2ccc(cc12)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F3N7O4/c24-23(25,26)20-15-5-8-31(13-3-6-30(7-4-13)32-9-10-36-12-18(32)34)22(35)19(15)33(28-20)14-1-2-17-16(11-14)21(27)29-37-17/h1-2,11,13H,3-10,12H2,(H2,27,29)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387083
PNG
(4-(4-(1-(3-Fluoronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES Fc1cc2ccccc2cc1-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C26H25F4N5O3/c27-20-13-16-3-1-2-4-17(16)14-21(20)35-23-19(24(31-35)26(28,29)30)7-10-33(25(23)37)18-5-8-32(9-6-18)34-11-12-38-15-22(34)36/h1-4,13-14,18H,5-12,15H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM19023
PNG
(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O
Show InChI InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Coagulation factor X


(Homo sapiens (Human))
BDBM387050
PNG
(1-(4-Methoxyphenyl)-6-(2′-oxo-[1,1′-bi...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O3/c1-35-18-7-5-17(6-8-18)32-21-19(22(28-32)24(25,26)27)11-15-30(23(21)34)16-9-13-29(14-10-16)31-12-3-2-4-20(31)33/h5-8,16H,2-4,9-15H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387050
PNG
(1-(4-Methoxyphenyl)-6-(2′-oxo-[1,1′-bi...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O3/c1-35-18-7-5-17(6-8-18)32-21-19(22(28-32)24(25,26)27)11-15-30(23(21)34)16-9-13-29(14-10-16)31-12-3-2-4-20(31)33/h5-8,16H,2-4,9-15H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387058
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(1-(3-oxomorpholino)pi...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O5/c1-33-17-4-2-16(3-5-17)29-21-18(20(25-29)22(24)31)8-11-27(23(21)32)15-6-9-26(10-7-15)28-12-13-34-14-19(28)30/h2-5,15H,6-14H2,1H3,(H2,24,31)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387080
PNG
(4-(4-(1-(3-Aminobenzo[d]isoxazol-5-yl)-7-oxo-3-(tr...)
Show SMILES Nc1noc2ccc(cc12)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F3N7O4/c24-23(25,26)20-15-5-8-31(13-3-6-30(7-4-13)32-9-10-36-12-18(32)34)22(35)19(15)33(28-20)14-1-2-17-16(11-14)21(27)29-37-17/h1-2,11,13H,3-10,12H2,(H2,27,29)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387082
PNG
(4-(4-(1-(3-Fluoro-4-methoxyphenyl)-7-oxo-3-(triflu...)
Show SMILES COc1ccc(cc1F)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F4N5O4/c1-35-18-3-2-15(12-17(18)24)32-20-16(21(28-32)23(25,26)27)6-9-30(22(20)34)14-4-7-29(8-5-14)31-10-11-36-13-19(31)33/h2-3,12,14H,4-11,13H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387085
PNG
(3-(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-3-(...)
Show SMILES NC(=O)c1cccc(c1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F3N6O4/c24-23(25,26)20-17-6-9-30(15-4-7-29(8-5-15)31-10-11-36-13-18(31)33)22(35)19(17)32(28-20)16-3-1-2-14(12-16)21(27)34/h1-3,12,15H,4-11,13H2,(H2,27,34)
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North China Pharmaceutical Company., Ltd.

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Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387056
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H28N6O3/c1-33-19-7-5-18(6-8-19)30-23-20(21(16-25)26-30)11-15-28(24(23)32)17-9-13-27(14-10-17)29-12-3-2-4-22(29)31/h5-8,17H,2-4,9-15H2,1H3
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387066
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(3-(2-oxopiperidin-1-y...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3C4CN(CC34)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H28N6O4/c1-34-15-7-5-14(6-8-15)30-22-16(20(26-30)23(25)32)9-11-28(24(22)33)21-17-12-27(13-18(17)21)29-10-3-2-4-19(29)31/h5-8,17-18,21H,2-4,9-13H2,1H3,(H2,25,32)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM19023
PNG
(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O
Show InChI InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Coagulation factor X


(Homo sapiens (Human))
BDBM387056
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H28N6O3/c1-33-19-7-5-18(6-8-19)30-23-20(21(16-25)26-30)11-15-28(24(23)32)17-9-13-27(14-10-17)29-12-3-2-4-22(29)31/h5-8,17H,2-4,9-15H2,1H3
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387065
PNG
(1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C23H26F2N6O5/c24-23(25)36-16-3-1-15(2-4-16)31-20-17(19(27-31)21(26)33)7-10-29(22(20)34)14-5-8-28(9-6-14)30-11-12-35-13-18(30)32/h1-4,14,23H,5-13H2,(H2,26,33)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387069
PNG
(1-(4-Methoxyphenyl)-N5-(1-(3-oxomorpholino)piperid...)
Show SMILES COc1ccc(cc1)-n1nc(cc1C(=O)NC1CCN(CC1)N1CCOCC1=O)C(N)=O
Show InChI InChI=1S/C21H26N6O5/c1-31-16-4-2-15(3-5-16)27-18(12-17(24-27)20(22)29)21(30)23-14-6-8-25(9-7-14)26-10-11-32-13-19(26)28/h2-5,12,14H,6-11,13H2,1H3,(H2,22,29)(H,23,30)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387077
PNG
(4-(4-(1-(4-(Difluoromethoxy)phenyl)-7-oxo-3-(trifl...)
Show SMILES FC(F)Oc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F5N5O4/c24-22(25)37-16-3-1-15(2-4-16)33-19-17(20(29-33)23(26,27)28)7-10-31(21(19)35)14-5-8-30(9-6-14)32-11-12-36-13-18(32)34/h1-4,14,22H,5-13H2
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387081
PNG
(3-(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-3-(...)
Show SMILES FC(F)(F)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1cccc(c1)C#N
Show InChI InChI=1S/C23H23F3N6O3/c24-23(25,26)21-18-6-9-30(16-4-7-29(8-5-16)31-10-11-35-14-19(31)33)22(34)20(18)32(28-21)17-3-1-2-15(12-17)13-27/h1-3,12,16H,4-11,14H2
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387055
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-28(24(22)33)16-9-13-27(14-10-16)29-12-3-2-4-20(29)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387059
PNG
(US9938272, Example 8a | US9938272, Example 8b)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)C3CCNC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O4/c1-33-16-4-2-15(3-5-16)29-20-17(19(26-29)21(24)30)9-13-28(23(20)32)14-7-11-27(12-8-14)18-6-10-25-22(18)31/h2-5,14,18H,6-13H2,1H3,(H2,24,30)(H,25,31)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387063
PNG
(1-(4-Chlorophenyl)-7-oxo-6-(1-(3-oxomorpholino)pip...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(Cl)cc1
Show InChI InChI=1S/C22H25ClN6O4/c23-14-1-3-16(4-2-14)29-20-17(19(25-29)21(24)31)7-10-27(22(20)32)15-5-8-26(9-6-15)28-11-12-33-13-18(28)30/h1-4,15H,5-13H2,(H2,24,31)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387069
PNG
(1-(4-Methoxyphenyl)-N5-(1-(3-oxomorpholino)piperid...)
Show SMILES COc1ccc(cc1)-n1nc(cc1C(=O)NC1CCN(CC1)N1CCOCC1=O)C(N)=O
Show InChI InChI=1S/C21H26N6O5/c1-31-16-4-2-15(3-5-16)27-18(12-17(24-27)20(22)29)21(30)23-14-6-8-25(9-7-14)26-10-11-32-13-19(26)28/h2-5,12,14H,6-11,13H2,1H3,(H2,22,29)(H,23,30)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387058
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(1-(3-oxomorpholino)pi...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O5/c1-33-17-4-2-16(3-5-17)29-21-18(20(25-29)22(24)31)8-11-27(23(21)32)15-6-9-26(10-7-15)28-12-13-34-14-19(28)30/h2-5,15H,6-14H2,1H3,(H2,24,31)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387059
PNG
(US9938272, Example 8a | US9938272, Example 8b)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)C3CCNC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O4/c1-33-16-4-2-15(3-5-16)29-20-17(19(26-29)21(24)30)9-13-28(23(20)32)14-7-11-27(12-8-14)18-6-10-25-22(18)31/h2-5,14,18H,6-13H2,1H3,(H2,24,30)(H,25,31)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387074
PNG
(N5-(1-(3-Oxomorpholino)piperidin-4-yl)-1-(tetrahyd...)
Show SMILES NC(=O)c1cc(C(=O)NC2CCN(CC2)N2CCOCC2=O)n(n1)C1CCOCC1
Show InChI InChI=1S/C19H28N6O5/c20-18(27)15-11-16(25(22-15)14-3-8-29-9-4-14)19(28)21-13-1-5-23(6-2-13)24-7-10-30-12-17(24)26/h11,13-14H,1-10,12H2,(H2,20,27)(H,21,28)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387085
PNG
(3-(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-3-(...)
Show SMILES NC(=O)c1cccc(c1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F3N6O4/c24-23(25,26)20-17-6-9-30(15-4-7-29(8-5-15)31-10-11-36-13-18(31)33)22(35)19(17)32(28-20)16-3-1-2-14(12-16)21(27)34/h1-3,12,15H,4-11,13H2,(H2,27,34)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387085
PNG
(3-(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-3-(...)
Show SMILES NC(=O)c1cccc(c1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F3N6O4/c24-23(25,26)20-17-6-9-30(15-4-7-29(8-5-15)31-10-11-36-13-18(31)33)22(35)19(17)32(28-20)16-3-1-2-14(12-16)21(27)34/h1-3,12,15H,4-11,13H2,(H2,27,34)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387057
PNG
(N′-Cyano-1-(4-methoxyphenyl)-7-oxo-6-(2̸...)
Show SMILES COc1ccc(cc1)-n1nc(\C(N)=N/C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C25H30N8O3/c1-36-19-7-5-18(6-8-19)33-23-20(22(29-33)24(27)28-16-26)11-15-31(25(23)35)17-9-13-30(14-10-17)32-12-3-2-4-21(32)34/h5-8,17H,2-4,9-15H2,1H3,(H2,27,28)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387059
PNG
(US9938272, Example 8a | US9938272, Example 8b)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)C3CCNC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O4/c1-33-16-4-2-15(3-5-16)29-20-17(19(26-29)21(24)30)9-13-28(23(20)32)14-7-11-27(12-8-14)18-6-10-25-22(18)31/h2-5,14,18H,6-13H2,1H3,(H2,24,30)(H,25,31)
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30n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387067
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(3-(3-oxomorpholino)-3...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3C4CN(CC34)N3CCOCC3=O)C(=O)c12
Show InChI InChI=1S/C23H26N6O5/c1-33-14-4-2-13(3-5-14)29-21-15(19(25-29)22(24)31)6-7-27(23(21)32)20-16-10-26(11-17(16)20)28-8-9-34-12-18(28)30/h2-5,16-17,20H,6-12H2,1H3,(H2,24,31)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
prothrombinase


(Homo sapiens (Human))
BDBM387064
PNG
(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-1-(4-(...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N6O5/c24-23(25,26)37-16-3-1-15(2-4-16)32-20-17(19(28-32)21(27)34)7-10-30(22(20)35)14-5-8-29(9-6-14)31-11-12-36-13-18(31)33/h1-4,14H,5-13H2,(H2,27,34)
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525n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Prothrombinase Assay:The effect of test compounds on prothrombinase activity is measured via thrombin generation. Briefly, 12.5 μL human factor ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387064
PNG
(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-1-(4-(...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N6O5/c24-23(25,26)37-16-3-1-15(2-4-16)32-20-17(19(28-32)21(27)34)7-10-30(22(20)35)14-5-8-29(9-6-14)31-11-12-36-13-18(31)33/h1-4,14H,5-13H2,(H2,27,34)
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525n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387087
PNG
(2-(Difluoromethoxy)-5-(7-oxo-6-(1-(3-oxomorpholino...)
Show SMILES NC(=O)c1cc(ccc1OC(F)F)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C24H25F5N6O5/c25-23(26)40-17-2-1-14(11-16(17)21(30)37)35-19-15(20(31-35)24(27,28)29)5-8-33(22(19)38)13-3-6-32(7-4-13)34-9-10-39-12-18(34)36/h1-2,11,13,23H,3-10,12H2,(H2,30,37)
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525n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387075
PNG
(1-(1-(Methylsulfonyl)piperidin-4-yl)-N5-(1-(3-oxom...)
Show SMILES CS(=O)(=O)N1CCC(CC1)n1nc(cc1C(=O)NC1CCN(CC1)N1CCOCC1=O)C(N)=O
Show InChI InChI=1S/C20H31N7O6S/c1-34(31,32)25-8-4-15(5-9-25)27-17(12-16(23-27)19(21)29)20(30)22-14-2-6-24(7-3-14)26-10-11-33-13-18(26)28/h12,14-15H,2-11,13H2,1H3,(H2,21,29)(H,22,30)
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525n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387059
PNG
(US9938272, Example 8a | US9938272, Example 8b)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)C3CCNC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O4/c1-33-16-4-2-15(3-5-16)29-20-17(19(26-29)21(24)30)9-13-28(23(20)32)14-7-11-27(12-8-14)18-6-10-25-22(18)31/h2-5,14,18H,6-13H2,1H3,(H2,24,30)(H,25,31)
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525n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387079
PNG
(2-Fluoro-5-(7-oxo-6-(1-(3-oxomorpholino)piperidin-...)
Show SMILES Fc1ccc(cc1C#N)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H22F4N6O3/c24-18-2-1-16(11-14(18)12-28)33-20-17(21(29-33)23(25,26)27)5-8-31(22(20)35)15-3-6-30(7-4-15)32-9-10-36-13-19(32)34/h1-2,11,15H,3-10,13H2
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525n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387071
PNG
(N5-Ethyl-1-(4-methoxyphenyl)-N5-(1-(3-oxomorpholin...)
Show SMILES CCN(C1CCN(CC1)N1CCOCC1=O)C(=O)c1cc(nn1-c1ccc(OC)cc1)C(N)=O
Show InChI InChI=1S/C23H30N6O5/c1-3-27(16-8-10-26(11-9-16)28-12-13-34-15-21(28)30)23(32)20-14-19(22(24)31)25-29(20)17-4-6-18(33-2)7-5-17/h4-7,14,16H,3,8-13,15H2,1-2H3,(H2,24,31)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387084
PNG
(2-(Difluoromethoxy)-5-(7-oxo-6-(1-(3-oxomorpholino...)
Show SMILES FC(F)Oc1ccc(cc1C#N)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C24H23F5N6O4/c25-23(26)39-18-2-1-16(11-14(18)12-30)35-20-17(21(31-35)24(27,28)29)5-8-33(22(20)37)15-3-6-32(7-4-15)34-9-10-38-13-19(34)36/h1-2,11,15,23H,3-10,13H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387086
PNG
(2-Fluoro-5-(7-oxo-6-(1-(3-oxomorpholino)piperidin-...)
Show SMILES NC(=O)c1cc(ccc1F)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F4N6O4/c24-17-2-1-14(11-16(17)21(28)35)33-19-15(20(29-33)23(25,26)27)5-8-31(22(19)36)13-3-6-30(7-4-13)32-9-10-37-12-18(32)34/h1-2,11,13H,3-10,12H2,(H2,28,35)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387076
PNG
(1-(4-Methoxycyclohexyl)-N5-(1-(3-oxomorpholino)pip...)
Show SMILES COC1CCC(CC1)n1nc(cc1C(=O)NC1CCN(CC1)N1CCOCC1=O)C(N)=O
Show InChI InChI=1S/C21H32N6O5/c1-31-16-4-2-15(3-5-16)27-18(12-17(24-27)20(22)29)21(30)23-14-6-8-25(9-7-14)26-10-11-32-13-19(26)28/h12,14-16H,2-11,13H2,1H3,(H2,22,29)(H,23,30)
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525n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387070
PNG
(1-(4-Methoxyphenyl)-N5-methyl-N5-(1-(3-oxomorpholi...)
Show SMILES COc1ccc(cc1)-n1nc(cc1C(=O)N(C)C1CCN(CC1)N1CCOCC1=O)C(N)=O
Show InChI InChI=1S/C22H28N6O5/c1-25(15-7-9-26(10-8-15)27-11-12-33-14-20(27)29)22(31)19-13-18(21(23)30)24-28(19)16-3-5-17(32-2)6-4-16/h3-6,13,15H,7-12,14H2,1-2H3,(H2,23,30)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387073
PNG
(1-(4-Methoxyphenyl)-N5-(1-(3-oxomorpholino)pyrroli...)
Show SMILES COc1ccc(cc1)-n1nc(cc1C(=O)NC1CCN(C1)N1CCOCC1=O)C(N)=O
Show InChI InChI=1S/C20H24N6O5/c1-30-15-4-2-14(3-5-15)26-17(10-16(23-26)19(21)28)20(29)22-13-6-7-24(11-13)25-8-9-31-12-18(25)27/h2-5,10,13H,6-9,11-12H2,1H3,(H2,21,28)(H,22,29)
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525n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Homo sapiens (Human))
BDBM387072
PNG
(N5-Cyclopropyl-1-(4-methoxyphenyl)-N5-(1-(3-oxomor...)
Show SMILES COc1ccc(cc1)-n1nc(cc1C(=O)N(C1CC1)C1CCN(CC1)N1CCOCC1=O)C(N)=O
Show InChI InChI=1S/C24H30N6O5/c1-34-19-6-4-18(5-7-19)30-21(14-20(26-30)23(25)32)24(33)29(16-2-3-16)17-8-10-27(11-9-17)28-12-13-35-15-22(28)31/h4-7,14,16-17H,2-3,8-13,15H2,1H3,(H2,25,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Coagulation factor X


(Rattus norvegicus (rat))
BDBM387068
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2-oxo-[1,4′-bip...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(N3CCC(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-29(24(22)33)27-13-9-16(10-14-27)28-12-3-2-4-20(28)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Factor Xa (human or rat): In the assay for measuring the inhibition of human or rat factor Xa activity, Tris-HCl buffer (50 mM, pH 8.3, 150 mM NaCl) ...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387083
PNG
(4-(4-(1-(3-Fluoronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES Fc1cc2ccccc2cc1-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C26H25F4N5O3/c27-20-13-16-3-1-2-4-17(16)14-21(20)35-23-19(24(31-35)26(28,29)30)7-10-33(25(23)37)18-5-8-32(9-6-18)34-11-12-38-15-22(34)36/h1-4,13-14,18H,5-12,15H2
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>1.00E+3n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM19023
PNG
(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O
Show InChI InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
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US Patent
>1.00E+3n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387049
PNG
(4-(4-(1-(4-Methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O4/c1-34-17-4-2-16(3-5-17)31-20-18(21(27-31)23(24,25)26)8-11-29(22(20)33)15-6-9-28(10-7-15)30-12-13-35-14-19(30)32/h2-5,15H,6-14H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387056
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H28N6O3/c1-33-19-7-5-18(6-8-19)30-23-20(21(16-25)26-30)11-15-28(24(23)32)17-9-13-27(14-10-17)29-12-3-2-4-22(29)31/h5-8,17H,2-4,9-15H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387057
PNG
(N′-Cyano-1-(4-methoxyphenyl)-7-oxo-6-(2̸...)
Show SMILES COc1ccc(cc1)-n1nc(\C(N)=N/C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C25H30N8O3/c1-36-19-7-5-18(6-8-19)33-23-20(22(29-33)24(27)28-16-26)11-15-31(25(23)35)17-9-13-30(14-10-17)32-12-3-2-4-21(32)34/h5-8,17H,2-4,9-15H2,1H3,(H2,27,28)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387083
PNG
(4-(4-(1-(3-Fluoronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES Fc1cc2ccccc2cc1-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C26H25F4N5O3/c27-20-13-16-3-1-2-4-17(16)14-21(20)35-23-19(24(31-35)26(28,29)30)7-10-33(25(23)37)18-5-8-32(9-6-18)34-11-12-38-15-22(34)36/h1-4,13-14,18H,5-12,15H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387085
PNG
(3-(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-3-(...)
Show SMILES NC(=O)c1cccc(c1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F3N6O4/c24-23(25,26)20-17-6-9-30(15-4-7-29(8-5-15)31-10-11-36-13-18(31)33)22(35)19(17)32(28-20)16-3-1-2-14(12-16)21(27)34/h1-3,12,15H,4-11,13H2,(H2,27,34)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387049
PNG
(4-(4-(1-(4-Methoxyphenyl)-7-oxo-3-(trifluoromethyl...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O4/c1-34-17-4-2-16(3-5-17)31-20-18(21(27-31)23(24,25)26)8-11-29(22(20)33)15-6-9-28(10-7-15)30-12-13-35-14-19(30)32/h2-5,15H,6-14H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387050
PNG
(1-(4-Methoxyphenyl)-6-(2′-oxo-[1,1′-bi...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O3/c1-35-18-7-5-17(6-8-18)32-21-19(22(28-32)24(25,26)27)11-15-30(23(21)34)16-9-13-29(14-10-16)31-12-3-2-4-20(31)33/h5-8,16H,2-4,9-15H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387054
PNG
(1-(4-Methoxyphenyl)-6-(1-(2-oxopyrrolidin-1-yl)pip...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O3/c1-34-17-6-4-16(5-7-17)31-20-18(21(27-31)23(24,25)26)10-14-29(22(20)33)15-8-12-28(13-9-15)30-11-2-3-19(30)32/h4-7,15H,2-3,8-14H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387058
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(1-(3-oxomorpholino)pi...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O5/c1-33-17-4-2-16(3-5-17)29-21-18(20(25-29)22(24)31)8-11-27(23(21)32)15-6-9-26(10-7-15)28-12-13-34-14-19(28)30/h2-5,15H,6-14H2,1H3,(H2,24,31)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387065
PNG
(1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C23H26F2N6O5/c24-23(25)36-16-3-1-15(2-4-16)31-20-17(19(27-31)21(26)33)7-10-29(22(20)34)14-5-8-28(9-6-14)30-11-12-35-13-18(30)32/h1-4,14,23H,5-13H2,(H2,26,33)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387068
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2-oxo-[1,4′-bip...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(N3CCC(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-29(24(22)33)27-13-9-16(10-14-27)28-12-3-2-4-20(28)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387064
PNG
(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-1-(4-(...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N6O5/c24-23(25,26)37-16-3-1-15(2-4-16)32-20-17(19(28-32)21(27)34)7-10-30(22(20)35)14-5-8-29(9-6-14)31-11-12-36-13-18(31)33/h1-4,14H,5-13H2,(H2,27,34)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387064
PNG
(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-1-(4-(...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C23H25F3N6O5/c24-23(25,26)37-16-3-1-15(2-4-16)32-20-17(19(28-32)21(27)34)7-10-30(22(20)35)14-5-8-29(9-6-14)31-11-12-36-13-18(31)33/h1-4,14H,5-13H2,(H2,27,34)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387078
PNG
(4-(4-(1-(6-Chloronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES FC(F)(F)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc2cc(Cl)ccc2c1
Show InChI InChI=1S/C26H25ClF3N5O3/c27-18-3-1-17-14-20(4-2-16(17)13-18)35-23-21(24(31-35)26(28,29)30)7-10-33(25(23)37)19-5-8-32(9-6-19)34-11-12-38-15-22(34)36/h1-4,13-14,19H,5-12,15H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387085
PNG
(3-(7-Oxo-6-(1-(3-oxomorpholino)piperidin-4-yl)-3-(...)
Show SMILES NC(=O)c1cccc(c1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F3N6O4/c24-23(25,26)20-17-6-9-30(15-4-7-29(8-5-15)31-10-11-36-13-18(31)33)22(35)19(17)32(28-20)16-3-1-2-14(12-16)21(27)34/h1-3,12,15H,4-11,13H2,(H2,27,34)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM19023
PNG
(1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-y...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C(=O)c12)c1ccc(cc1)N1CCCCC1=O
Show InChI InChI=1S/C25H25N5O4/c1-34-19-11-9-18(10-12-19)30-23-20(22(27-30)24(26)32)13-15-29(25(23)33)17-7-5-16(6-8-17)28-14-3-2-4-21(28)31/h5-12H,2-4,13-15H2,1H3,(H2,26,32)
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>1.00E+3n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387055
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-28(24(22)33)16-9-13-27(14-10-16)29-12-3-2-4-20(29)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387065
PNG
(1-(4-(Difluoromethoxy)phenyl)-7-oxo-6-(1-(3-oxomor...)
Show SMILES NC(=O)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc(OC(F)F)cc1
Show InChI InChI=1S/C23H26F2N6O5/c24-23(25)36-16-3-1-15(2-4-16)31-20-17(19(27-31)21(26)33)7-10-29(22(20)34)14-5-8-28(9-6-14)30-11-12-35-13-18(30)32/h1-4,14,23H,5-13H2,(H2,26,33)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387077
PNG
(4-(4-(1-(4-(Difluoromethoxy)phenyl)-7-oxo-3-(trifl...)
Show SMILES FC(F)Oc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F5N5O4/c24-22(25)37-16-3-1-15(2-4-16)33-19-17(20(29-33)23(26,27)28)7-10-31(21(19)35)14-5-8-30(9-6-14)32-11-12-36-13-18(32)34/h1-4,14,22H,5-13H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387082
PNG
(4-(4-(1-(3-Fluoro-4-methoxyphenyl)-7-oxo-3-(triflu...)
Show SMILES COc1ccc(cc1F)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F4N5O4/c1-35-18-3-2-15(12-17(18)24)32-20-16(21(28-32)23(25,26)27)6-9-30(22(20)34)14-4-7-29(8-5-14)31-10-11-36-13-19(31)33/h2-3,12,14H,4-11,13H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387080
PNG
(4-(4-(1-(3-Aminobenzo[d]isoxazol-5-yl)-7-oxo-3-(tr...)
Show SMILES Nc1noc2ccc(cc12)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F3N7O4/c24-23(25,26)20-15-5-8-31(13-3-6-30(7-4-13)32-9-10-36-12-18(32)34)22(35)19(15)33(28-20)14-1-2-17-16(11-14)21(27)29-37-17/h1-2,11,13H,3-10,12H2,(H2,27,29)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387058
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(1-(3-oxomorpholino)pi...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O5/c1-33-17-4-2-16(3-5-17)29-21-18(20(25-29)22(24)31)8-11-27(23(21)32)15-6-9-26(10-7-15)28-12-13-34-14-19(28)30/h2-5,15H,6-14H2,1H3,(H2,24,31)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387055
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-28(24(22)33)16-9-13-27(14-10-16)29-12-3-2-4-20(29)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387054
PNG
(1-(4-Methoxyphenyl)-6-(1-(2-oxopyrrolidin-1-yl)pip...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H26F3N5O3/c1-34-17-6-4-16(5-7-17)31-20-18(21(27-31)23(24,25)26)10-14-29(22(20)33)15-8-12-28(13-9-15)30-11-2-3-19(30)32/h4-7,15H,2-3,8-14H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387080
PNG
(4-(4-(1-(3-Aminobenzo[d]isoxazol-5-yl)-7-oxo-3-(tr...)
Show SMILES Nc1noc2ccc(cc12)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F3N7O4/c24-23(25,26)20-15-5-8-31(13-3-6-30(7-4-13)32-9-10-36-12-18(32)34)22(35)19(15)33(28-20)14-1-2-17-16(11-14)21(27)29-37-17/h1-2,11,13H,3-10,12H2,(H2,27,29)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387078
PNG
(4-(4-(1-(6-Chloronaphthalen-2-yl)-7-oxo-3-(trifluo...)
Show SMILES FC(F)(F)c1nn(c2c1CCN(C1CCN(CC1)N1CCOCC1=O)C2=O)-c1ccc2cc(Cl)ccc2c1
Show InChI InChI=1S/C26H25ClF3N5O3/c27-18-3-1-17-14-20(4-2-16(17)13-18)35-23-21(24(31-35)26(28,29)30)7-10-33(25(23)37)19-5-8-32(9-6-19)34-11-12-38-15-22(34)36/h1-4,13-14,19H,5-12,15H2
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>1.00E+3n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387059
PNG
(US9938272, Example 8a | US9938272, Example 8b)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)C3CCNC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O4/c1-33-16-4-2-15(3-5-16)29-20-17(19(26-29)21(24)30)9-13-28(23(20)32)14-7-11-27(12-8-14)18-6-10-25-22(18)31/h2-5,14,18H,6-13H2,1H3,(H2,24,30)(H,25,31)
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>1.00E+3n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387057
PNG
(N′-Cyano-1-(4-methoxyphenyl)-7-oxo-6-(2̸...)
Show SMILES COc1ccc(cc1)-n1nc(\C(N)=N/C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C25H30N8O3/c1-36-19-7-5-18(6-8-19)33-23-20(22(29-33)24(27)28-16-26)11-15-31(25(23)35)17-9-13-30(14-10-17)32-12-3-2-4-21(32)34/h5-8,17H,2-4,9-15H2,1H3,(H2,27,28)
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>1.00E+3n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387050
PNG
(1-(4-Methoxyphenyl)-6-(2′-oxo-[1,1′-bi...)
Show SMILES COc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C24H28F3N5O3/c1-35-18-7-5-17(6-8-18)32-21-19(22(28-32)24(25,26)27)11-15-30(23(21)34)16-9-13-29(14-10-16)31-12-3-2-4-20(31)33/h5-8,16H,2-4,9-15H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387082
PNG
(4-(4-(1-(3-Fluoro-4-methoxyphenyl)-7-oxo-3-(triflu...)
Show SMILES COc1ccc(cc1F)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H25F4N5O4/c1-35-18-3-2-15(12-17(18)24)32-20-16(21(28-32)23(25,26)27)6-9-30(22(20)34)14-4-7-29(8-5-14)31-10-11-36-13-19(31)33/h2-3,12,14H,4-11,13H2,1H3
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>1.00E+3n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387077
PNG
(4-(4-(1-(4-(Difluoromethoxy)phenyl)-7-oxo-3-(trifl...)
Show SMILES FC(F)Oc1ccc(cc1)-n1nc(c2CCN(C3CCN(CC3)N3CCOCC3=O)C(=O)c12)C(F)(F)F
Show InChI InChI=1S/C23H24F5N5O4/c24-22(25)37-16-3-1-15(2-4-16)33-19-17(20(29-33)23(26,27)28)7-10-31(21(19)35)14-5-8-30(9-6-14)32-11-12-36-13-18(32)34/h1-4,14,22H,5-13H2
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387068
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2-oxo-[1,4′-bip...)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(N3CCC(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H30N6O4/c1-34-18-7-5-17(6-8-18)30-22-19(21(26-30)23(25)32)11-15-29(24(22)33)27-13-9-16(10-14-27)28-12-3-2-4-20(28)31/h5-8,16H,2-4,9-15H2,1H3,(H2,25,32)
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Trypsin-1


(Homo sapiens (Human))
BDBM387056
PNG
(1-(4-Methoxyphenyl)-7-oxo-6-(2′-oxo-[1,1R...)
Show SMILES COc1ccc(cc1)-n1nc(C#N)c2CCN(C3CCN(CC3)N3CCCCC3=O)C(=O)c12
Show InChI InChI=1S/C24H28N6O3/c1-33-19-7-5-18(6-8-19)30-23-20(21(16-25)26-30)11-15-28(24(23)32)17-9-13-27(14-10-17)29-12-3-2-4-22(29)31/h5-8,17H,2-4,9-15H2,1H3
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North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Trypsin: In the assay for measuring the inhibition of human trypsin activity buffer (50 mM Tris, pH 8.2, and 20 mM CaCl2) is used. The IC50 is measur...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
Thrombin and coagulation factor X


(Homo sapiens (Human))
BDBM387059
PNG
(US9938272, Example 8a | US9938272, Example 8b)
Show SMILES COc1ccc(cc1)-n1nc(C(N)=O)c2CCN(C3CCN(CC3)C3CCNC3=O)C(=O)c12
Show InChI InChI=1S/C23H28N6O4/c1-33-16-4-2-15(3-5-16)29-20-17(19(26-29)21(24)30)9-13-28(23(20)32)14-7-11-27(12-8-14)18-6-10-25-22(18)31/h2-5,14,18H,6-13H2,1H3,(H2,24,30)(H,25,31)
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>1.00E+3n/an/an/an/an/an/an/an/a



North China Pharmaceutical Company., Ltd.

US Patent


Assay Description
Thrombin: In the assay for measuring the inhibition of human thrombin activity buffer (10 mM HEPES buffer, pH 7.4, 2 mM CaCl2) is used. The IC50 is m...


US Patent US9938272 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%