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Patent code US9938274

Compile Data Set for Download or QSAR
Found 44 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387238
PNG
(US9938274, 4)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C33H26F2N4O4/c1-33(2,41)18-42-22-8-9-23-27(16-22)36-14-12-28(23)43-29-10-7-21(15-25(29)35)39-32-30-26(11-13-37-32)38-17-24(31(30)40)19-3-5-20(34)6-4-19/h3-17,41H,18H2,1-2H3,(H,37,39)(H,38,40)
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n/an/a 0.390n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387238
PNG
(US9938274, 4)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C33H26F2N4O4/c1-33(2,41)18-42-22-8-9-23-27(16-22)36-14-12-28(23)43-29-10-7-21(15-25(29)35)39-32-30-26(11-13-37-32)38-17-24(31(30)40)19-3-5-20(34)6-4-19/h3-17,41H,18H2,1-2H3,(H,37,39)(H,38,40)
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n/an/a 2.07n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387257
PNG
(US9938274, Comparative Compound C)
Show SMILES OCCOc1ccc2c(Oc3ccc(Nc4nccc5ncc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
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n/an/a 5.70n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387249
PNG
(US9938274, 12)
Show SMILES CCCn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc5cc(OCC(C)(C)O)ccc45)c(F)c3)nccc12
Show InChI InChI=1S/C36H32F2N4O4/c1-4-17-42-20-27(22-5-7-23(37)8-6-22)34(43)33-30(42)13-15-40-35(33)41-24-9-12-32(28(38)18-24)46-31-14-16-39-29-19-25(10-11-26(29)31)45-21-36(2,3)44/h5-16,18-20,44H,4,17,21H2,1-3H3,(H,40,41)
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n/an/a 7.20n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387242
PNG
(US9938274, 7)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C33H27FN4O4/c1-33(2,40)19-41-22-9-10-23-27(17-22)35-15-13-28(23)42-29-11-8-21(16-25(29)34)38-32-30-26(12-14-36-32)37-18-24(31(30)39)20-6-4-3-5-7-20/h3-18,40H,19H2,1-2H3,(H,36,38)(H,37,39)
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n/an/a 7.40n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387241
PNG
(US9938274, 6)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6cccc(F)c6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C33H26F2N4O4/c1-33(2,41)18-42-22-7-8-23-27(16-22)36-13-11-28(23)43-29-9-6-21(15-25(29)35)39-32-30-26(10-12-37-32)38-17-24(31(30)40)19-4-3-5-20(34)14-19/h3-17,41H,18H2,1-2H3,(H,37,39)(H,38,40)
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n/an/a 7.90n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387257
PNG
(US9938274, Comparative Compound C)
Show SMILES OCCOc1ccc2c(Oc3ccc(Nc4nccc5ncc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
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n/an/a 8.5n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387250
PNG
(US9938274, 13)
Show SMILES CC(C)n1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc5cc(OCC(C)(C)O)ccc45)c(F)c3)nccc12
Show InChI InChI=1S/C36H32F2N4O4/c1-21(2)42-19-27(22-5-7-23(37)8-6-22)34(43)33-30(42)13-15-40-35(33)41-24-9-12-32(28(38)17-24)46-31-14-16-39-29-18-25(10-11-26(29)31)45-20-36(3,4)44/h5-19,21,44H,20H2,1-4H3,(H,40,41)
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n/an/a 9n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387239
PNG
(US9938274, 5)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6F)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C33H26F2N4O4/c1-33(2,41)18-42-20-8-9-22-27(16-20)36-14-12-28(22)43-29-10-7-19(15-25(29)35)39-32-30-26(11-13-37-32)38-17-23(31(30)40)21-5-3-4-6-24(21)34/h3-17,41H,18H2,1-2H3,(H,37,39)(H,38,40)
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n/an/a 9.40n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387248
PNG
(US9938274, 11)
Show SMILES CCn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc5cc(OCC(C)(C)O)ccc45)c(F)c3)nccc12
Show InChI InChI=1S/C35H30F2N4O4/c1-4-41-19-26(21-5-7-22(36)8-6-21)33(42)32-29(41)13-15-39-34(32)40-23-9-12-31(27(37)17-23)45-30-14-16-38-28-18-24(10-11-25(28)30)44-20-35(2,3)43/h5-19,43H,4,20H2,1-3H3,(H,39,40)
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n/an/a 9.5n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387242
PNG
(US9938274, 7)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C33H27FN4O4/c1-33(2,40)19-41-22-9-10-23-27(17-22)35-15-13-28(23)42-29-11-8-21(16-25(29)34)38-32-30-26(12-14-36-32)37-18-24(31(30)39)20-6-4-3-5-7-20/h3-18,40H,19H2,1-2H3,(H,36,38)(H,37,39)
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n/an/a 10.2n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387258
PNG
(US9938274, Comparative Compound D)
Show SMILES COC(C)(C)Oc1ccc2c(Oc3ccc(Nc4nccc5ncc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
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n/an/a 12.1n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387245
PNG
(US9938274, 10)
Show SMILES Cn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc5cc(OCC(C)(C)O)ccc45)c(F)c3)nccc12
Show InChI InChI=1S/C34H28F2N4O4/c1-34(2,42)19-43-23-9-10-24-27(17-23)37-15-13-29(24)44-30-11-8-22(16-26(30)36)39-33-31-28(12-14-38-33)40(3)18-25(32(31)41)20-4-6-21(35)7-5-20/h4-18,42H,19H2,1-3H3,(H,38,39)
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n/an/a 12.7n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387244
PNG
(US9938274, 9)
Show SMILES COc1cc2nccc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)c2cc1OCC(C)(C)O
Show InChI InChI=1S/C34H29FN4O5/c1-34(2,41)19-43-30-16-22-26(17-29(30)42-3)36-14-12-27(22)44-28-10-9-21(15-24(28)35)39-33-31-25(11-13-37-33)38-18-23(32(31)40)20-7-5-4-6-8-20/h4-18,41H,19H2,1-3H3,(H,37,39)(H,38,40)
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n/an/a 13.3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387251
PNG
(US9938274, 14)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5n(cc(-c6ccc(F)cc6)c(=O)c45)C4CC4)cc3F)ccnc2c1
Show InChI InChI=1S/C36H30F2N4O4/c1-36(2,44)20-45-25-10-11-26-29(18-25)39-16-14-31(26)46-32-12-7-23(17-28(32)38)41-35-33-30(13-15-40-35)42(24-8-9-24)19-27(34(33)43)21-3-5-22(37)6-4-21/h3-7,10-19,24,44H,8-9,20H2,1-2H3,(H,40,41)
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n/an/a 14.3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387253
PNG
(US9938274, 16)
Show SMILES COCCn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc5cc(OCC(C)(C)O)ccc45)c(F)c3)nccc12
Show InChI InChI=1S/C36H32F2N4O5/c1-36(2,44)21-46-25-9-10-26-29(19-25)39-15-13-31(26)47-32-11-8-24(18-28(32)38)41-35-33-30(12-14-40-35)42(16-17-45-3)20-27(34(33)43)22-4-6-23(37)7-5-22/h4-15,18-20,44H,16-17,21H2,1-3H3,(H,40,41)
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n/an/a 14.4n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387236
PNG
(US9938274, 2)
Show SMILES COc1cc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2cc1OCC(C)O
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n/an/a 15.6n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387243
PNG
(US9938274, 8)
Show SMILES COc1cc2nccc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OCC(C)(C)O
Show InChI InChI=1S/C34H28F2N4O5/c1-34(2,42)18-44-30-15-22-26(16-29(30)43-3)37-13-11-27(22)45-28-9-8-21(14-24(28)36)40-33-31-25(10-12-38-33)39-17-23(32(31)41)19-4-6-20(35)7-5-19/h4-17,42H,18H2,1-3H3,(H,38,40)(H,39,41)
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n/an/a 16.8n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387235
PNG
(US9938274, 1)
Show SMILES COc1cc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2cc1OCC(C)(C)O
Show InChI InChI=1S/C34H28F2N4O5/c1-34(2,42)18-44-30-16-26-22(15-29(30)43-3)27(11-13-37-26)45-28-9-8-21(14-24(28)36)40-33-31-25(10-12-38-33)39-17-23(32(31)41)19-4-6-20(35)7-5-19/h4-17,42H,18H2,1-3H3,(H,38,40)(H,39,41)
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n/an/a 19.4n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387237
PNG
(US9938274, 3)
Show SMILES COc1cc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)ccnc2cc1OCC(C)(C)O
Show InChI InChI=1S/C34H29FN4O5/c1-34(2,41)19-43-30-17-26-22(16-29(30)42-3)27(12-14-36-26)44-28-10-9-21(15-24(28)35)39-33-31-25(11-13-37-33)38-18-23(32(31)40)20-7-5-4-6-8-20/h4-18,41H,19H2,1-3H3,(H,37,39)(H,38,40)
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n/an/a 20.1n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387252
PNG
(US9938274, 15)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5n(CC6CO6)cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C36H30F2N4O5/c1-36(2,44)20-46-24-8-9-26-29(16-24)39-14-12-31(26)47-32-10-7-23(15-28(32)38)41-35-33-30(11-13-40-35)42(17-25-19-45-25)18-27(34(33)43)21-3-5-22(37)6-4-21/h3-16,18,25,44H,17,19-20H2,1-2H3,(H,40,41)
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n/an/a 22.4n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387244
PNG
(US9938274, 9)
Show SMILES COc1cc2nccc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)c2cc1OCC(C)(C)O
Show InChI InChI=1S/C34H29FN4O5/c1-34(2,41)19-43-30-16-22-26(17-29(30)42-3)36-14-12-27(22)44-28-10-9-21(15-24(28)35)39-33-31-25(11-13-37-33)38-18-23(32(31)40)20-7-5-4-6-8-20/h4-18,41H,19H2,1-3H3,(H,37,39)(H,38,40)
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n/an/a 28n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387236
PNG
(US9938274, 2)
Show SMILES COc1cc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2cc1OCC(C)O
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n/an/a 28.4n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387239
PNG
(US9938274, 5)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6F)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C33H26F2N4O4/c1-33(2,41)18-42-20-8-9-22-27(16-20)36-14-12-28(22)43-29-10-7-19(15-25(29)35)39-32-30-26(11-13-37-32)38-17-23(31(30)40)21-5-3-4-6-24(21)34/h3-17,41H,18H2,1-2H3,(H,37,39)(H,38,40)
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n/an/a 29.5n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387241
PNG
(US9938274, 6)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6cccc(F)c6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C33H26F2N4O4/c1-33(2,41)18-42-22-7-8-23-27(16-22)36-13-11-28(23)43-29-9-6-21(15-25(29)35)39-32-30-26(10-12-37-32)38-17-24(31(30)40)19-4-3-5-20(34)14-19/h3-17,41H,18H2,1-2H3,(H,37,39)(H,38,40)
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n/an/a 31.2n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387243
PNG
(US9938274, 8)
Show SMILES COc1cc2nccc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OCC(C)(C)O
Show InChI InChI=1S/C34H28F2N4O5/c1-34(2,42)18-44-30-15-22-26(16-29(30)43-3)37-13-11-27(22)45-28-9-8-21(14-24(28)36)40-33-31-25(10-12-38-33)39-17-23(32(31)41)19-4-6-20(35)7-5-19/h4-17,42H,18H2,1-3H3,(H,38,40)(H,39,41)
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n/an/a 36.4n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387254
PNG
(US9938274, 17)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5n(CCO)cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C35H30F2N4O5/c1-35(2,44)20-45-24-8-9-25-28(18-24)38-14-12-30(25)46-31-10-7-23(17-27(31)37)40-34-32-29(11-13-39-34)41(15-16-42)19-26(33(32)43)21-3-5-22(36)6-4-21/h3-14,17-19,42,44H,15-16,20H2,1-2H3,(H,39,40)
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n/an/a 40n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387255
PNG
(US9938274, 18)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5n(Cc6ccccc6)cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C40H32F2N4O4/c1-40(2,48)24-49-29-13-14-30-33(21-29)43-19-17-35(30)50-36-15-12-28(20-32(36)42)45-39-37-34(16-18-44-39)46(22-25-6-4-3-5-7-25)23-31(38(37)47)26-8-10-27(41)11-9-26/h3-21,23,48H,22,24H2,1-2H3,(H,44,45)
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n/an/a 40.3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387235
PNG
(US9938274, 1)
Show SMILES COc1cc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2cc1OCC(C)(C)O
Show InChI InChI=1S/C34H28F2N4O5/c1-34(2,42)18-44-30-16-26-22(15-29(30)43-3)27(11-13-37-26)45-28-9-8-21(14-24(28)36)40-33-31-25(10-12-38-33)39-17-23(32(31)41)19-4-6-20(35)7-5-19/h4-17,42H,18H2,1-3H3,(H,38,40)(H,39,41)
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n/an/a 47.1n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387237
PNG
(US9938274, 3)
Show SMILES COc1cc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccccc6)c(=O)c45)cc3F)ccnc2cc1OCC(C)(C)O
Show InChI InChI=1S/C34H29FN4O5/c1-34(2,41)19-43-30-17-26-22(16-29(30)42-3)27(12-14-36-26)44-28-10-9-21(15-24(28)35)39-33-31-25(11-13-37-33)38-18-23(32(31)40)20-7-5-4-6-8-20/h4-18,41H,19H2,1-3H3,(H,37,39)(H,38,40)
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n/an/a 48.9n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387258
PNG
(US9938274, Comparative Compound D)
Show SMILES COC(C)(C)Oc1ccc2c(Oc3ccc(Nc4nccc5ncc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
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n/an/a 60n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387259
PNG
(US9938274, Comparative Compound A)
Show SMILES COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C30H20F2N4O3/c1-38-20-7-8-21-25(15-20)33-13-11-26(21)39-27-9-6-19(14-23(27)32)36-30-28-24(10-12-34-30)35-16-22(29(28)37)17-2-4-18(31)5-3-17/h2-16H,1H3,(H,34,36)(H,35,37)
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n/an/a 68.3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387259
PNG
(US9938274, Comparative Compound A)
Show SMILES COc1ccc2c(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C30H20F2N4O3/c1-38-20-7-8-21-25(15-20)33-13-11-26(21)39-27-9-6-19(14-23(27)32)36-30-28-24(10-12-34-30)35-16-22(29(28)37)17-2-4-18(31)5-3-17/h2-16H,1H3,(H,34,36)(H,35,37)
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n/an/a 125n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))		BDBM387260
PNG
(US9938274, Comparative Compound B)
Show SMILES COc1cc2nccc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OC
Show InChI InChI=1S/C31H22F2N4O4/c1-39-27-14-20-24(15-28(27)40-2)34-12-10-25(20)41-26-8-7-19(13-22(26)33)37-31-29-23(9-11-35-31)36-16-21(30(29)38)17-3-5-18(32)6-4-17/h3-16H,1-2H3,(H,35,37)(H,36,38)
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n/an/a 143n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387260
PNG
(US9938274, Comparative Compound B)
Show SMILES COc1cc2nccc(Oc3ccc(Nc4nccc5[nH]cc(-c6ccc(F)cc6)c(=O)c45)cc3F)c2cc1OC
Show InChI InChI=1S/C31H22F2N4O4/c1-39-27-14-20-24(15-28(27)40-2)34-12-10-25(20)41-26-8-7-19(13-22(26)33)37-31-29-23(9-11-35-31)36-16-21(30(29)38)17-3-5-18(32)6-4-17/h3-16H,1-2H3,(H,35,37)(H,36,38)
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n/an/a 182n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387250
PNG
(US9938274, 13)
Show SMILES CC(C)n1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc5cc(OCC(C)(C)O)ccc45)c(F)c3)nccc12
Show InChI InChI=1S/C36H32F2N4O4/c1-21(2)42-19-27(22-5-7-23(37)8-6-22)34(43)33-30(42)13-15-40-35(33)41-24-9-12-32(28(38)17-24)46-31-14-16-39-29-18-25(10-11-26(29)31)45-20-36(3,4)44/h5-19,21,44H,20H2,1-4H3,(H,40,41)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387248
PNG
(US9938274, 11)
Show SMILES CCn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc5cc(OCC(C)(C)O)ccc45)c(F)c3)nccc12
Show InChI InChI=1S/C35H30F2N4O4/c1-4-41-19-26(21-5-7-22(36)8-6-21)33(42)32-29(41)13-15-39-34(32)40-23-9-12-31(27(37)17-23)45-30-14-16-38-28-18-24(10-11-25(28)30)44-20-35(2,3)43/h5-19,43H,4,20H2,1-3H3,(H,39,40)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387254
PNG
(US9938274, 17)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5n(CCO)cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C35H30F2N4O5/c1-35(2,44)20-45-24-8-9-25-28(18-24)38-14-12-30(25)46-31-10-7-23(17-27(31)37)40-34-32-29(11-13-39-34)41(15-16-42)19-26(33(32)43)21-3-5-22(36)6-4-21/h3-14,17-19,42,44H,15-16,20H2,1-2H3,(H,39,40)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387249
PNG
(US9938274, 12)
Show SMILES CCCn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc5cc(OCC(C)(C)O)ccc45)c(F)c3)nccc12
Show InChI InChI=1S/C36H32F2N4O4/c1-4-17-42-20-27(22-5-7-23(37)8-6-22)34(43)33-30(42)13-15-40-35(33)41-24-9-12-32(28(38)18-24)46-31-14-16-39-29-19-25(10-11-26(29)31)45-21-36(2,3)44/h5-16,18-20,44H,4,17,21H2,1-3H3,(H,40,41)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387252
PNG
(US9938274, 15)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5n(CC6CO6)cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C36H30F2N4O5/c1-36(2,44)20-46-24-8-9-26-29(16-24)39-14-12-31(26)47-32-10-7-23(15-28(32)38)41-35-33-30(11-13-40-35)42(17-25-19-45-25)18-27(34(33)43)21-3-5-22(37)6-4-21/h3-16,18,25,44H,17,19-20H2,1-2H3,(H,40,41)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387255
PNG
(US9938274, 18)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5n(Cc6ccccc6)cc(-c6ccc(F)cc6)c(=O)c45)cc3F)ccnc2c1
Show InChI InChI=1S/C40H32F2N4O4/c1-40(2,48)24-49-29-13-14-30-33(21-29)43-19-17-35(30)50-36-15-12-28(20-32(36)42)45-39-37-34(16-18-44-39)46(22-25-6-4-3-5-7-25)23-31(38(37)47)26-8-10-27(41)11-9-26/h3-21,23,48H,22,24H2,1-2H3,(H,44,45)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387245
PNG
(US9938274, 10)
Show SMILES Cn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc5cc(OCC(C)(C)O)ccc45)c(F)c3)nccc12
Show InChI InChI=1S/C34H28F2N4O4/c1-34(2,42)19-43-23-9-10-24-27(17-23)37-15-13-29(24)44-30-11-8-22(16-26(30)36)39-33-31-28(12-14-38-33)40(3)18-25(32(31)41)20-4-6-21(35)7-5-20/h4-18,42H,19H2,1-3H3,(H,38,39)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387253
PNG
(US9938274, 16)
Show SMILES COCCn1cc(-c2ccc(F)cc2)c(=O)c2c(Nc3ccc(Oc4ccnc5cc(OCC(C)(C)O)ccc45)c(F)c3)nccc12
Show InChI InChI=1S/C36H32F2N4O5/c1-36(2,44)21-46-25-9-10-26-29(19-25)39-15-13-31(26)47-32-11-8-24(18-28(32)38)41-35-33-30(12-14-40-35)42(16-17-45-3)20-27(34(33)43)22-4-6-23(37)7-5-22/h4-15,18-20,44H,16-17,21H2,1-3H3,(H,40,41)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))		BDBM387251
PNG
(US9938274, 14)
Show SMILES CC(C)(O)COc1ccc2c(Oc3ccc(Nc4nccc5n(cc(-c6ccc(F)cc6)c(=O)c45)C4CC4)cc3F)ccnc2c1
Show InChI InChI=1S/C36H30F2N4O4/c1-36(2,44)20-45-25-10-11-26-29(18-25)39-16-14-31(26)46-32-12-7-23(17-28(32)38)41-35-33-30(13-15-40-35)42(24-8-9-24)19-27(34(33)43)21-3-5-22(37)6-4-21/h3-7,10-19,24,44H,8-9,20H2,1-2H3,(H,40,41)
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n/an/a>5.00E+3n/an/an/an/an/an/a



NANJING NATINEFY PHARMATECH CO., LTD.

US Patent


Assay Description
A study on inhibition of protein kinases activity at in vitro biochemical levelMaterial and method: kinases such as c-Met, VEGFR-2, Axl and RET, obta...

US Patent US9938274 (2018)


BindingDB Entry DOI: 10.7270/Q2NK3HB6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%