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Patent code US9938289

Compile Data Set for Download or QSAR
Found 9 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM172452
PNG
(US9090625, 4 | US9260450, 4 | US9938289, 4)
Show SMILES CCc1cnn(c1-c1cc2cnccc2s1)-c1cccc(C)n1
Show InChI InChI=1S/C18H16N4S/c1-3-13-11-20-22(17-6-4-5-12(2)21-17)18(13)16-9-14-10-19-8-7-15(14)23-16/h4-11H,3H2,1-2H3
PDB

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UniChem

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US Patent
n/an/a 1.92n/an/an/an/an/an/a



FBM THERAPEUTICS, LLC

US Patent


Assay Description
ALK-5 kinase assay methods have been described in the art (see e.g., Laping et al. (2002) Mol. Pharmacol. 2002; 62: 58-62). The compounds named in th...


US Patent US9938289 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM172455
PNG
(US9090625, 7 | US9260450, 7 | US9938289, 7)
Show SMILES Cc1cnn(c1-c1cc2cnccc2s1)-c1cccc(C)n1
Show InChI InChI=1S/C17H14N4S/c1-11-9-19-21(16-5-3-4-12(2)20-16)17(11)15-8-13-10-18-7-6-14(13)22-15/h3-10H,1-2H3
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US Patent
n/an/a 6.65n/an/an/an/an/an/a



FBM THERAPEUTICS, LLC

US Patent


Assay Description
ALK-5 kinase assay methods have been described in the art (see e.g., Laping et al. (2002) Mol. Pharmacol. 2002; 62: 58-62). The compounds named in th...


US Patent US9938289 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM172457
PNG
(US9090625, 12 | US9260450, 12 | US9938289, 12)
Show SMILES Cc1cnn(c1-c1cc2ccncc2s1)-c1cccc(C)n1
Show InChI InChI=1S/C17H14N4S/c1-11-9-19-21(16-5-3-4-12(2)20-16)17(11)14-8-13-6-7-18-10-15(13)22-14/h3-10H,1-2H3
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US Patent
n/an/a 7.94n/an/an/an/an/an/a



FBM THERAPEUTICS, LLC

US Patent


Assay Description
ALK-5 kinase assay methods have been described in the art (see e.g., Laping et al. (2002) Mol. Pharmacol. 2002; 62: 58-62). The compounds named in th...


US Patent US9938289 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM172458
PNG
(US9090625, 13 | US9260450, 13 | US9938289, 13)
Show SMILES Cc1cccc(n1)-n1nc2CCCc2c1-c1cc2ccncc2s1
Show InChI InChI=1S/C19H16N4S/c1-12-4-2-7-18(21-12)23-19(14-5-3-6-15(14)22-23)16-10-13-8-9-20-11-17(13)24-16/h2,4,7-11H,3,5-6H2,1H3
PDB

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US Patent
n/an/a 18.9n/an/an/an/an/an/a



FBM THERAPEUTICS, LLC

US Patent


Assay Description
ALK-5 kinase assay methods have been described in the art (see e.g., Laping et al. (2002) Mol. Pharmacol. 2002; 62: 58-62). The compounds named in th...


US Patent US9938289 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM172453
PNG
(US9090625, 5 | US9260450, 5 | US9938289, 5)
Show SMILES Cc1cccc(n1)-n1nc2CCCc2c1-c1cc2cnccc2s1
Show InChI InChI=1S/C19H16N4S/c1-12-4-2-7-18(21-12)23-19(14-5-3-6-15(14)22-23)17-10-13-11-20-9-8-16(13)24-17/h2,4,7-11H,3,5-6H2,1H3
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US Patent
n/an/a 21.8n/an/an/an/an/an/a



FBM THERAPEUTICS, LLC

US Patent


Assay Description
ALK-5 kinase assay methods have been described in the art (see e.g., Laping et al. (2002) Mol. Pharmacol. 2002; 62: 58-62). The compounds named in th...


US Patent US9938289 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM172449
PNG
(US9090625, 1 | US9260450, 1 | US9938289, 1)
Show SMILES Cc1cccc(n1)-n1nccc1-c1cc2cnccc2s1
Show InChI InChI=1S/C16H12N4S/c1-11-3-2-4-16(19-11)20-13(5-8-18-20)15-9-12-10-17-7-6-14(12)21-15/h2-10H,1H3
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US Patent
n/an/a 23.4n/an/an/an/an/an/a



FBM THERAPEUTICS, LLC

US Patent


Assay Description
ALK-5 kinase assay methods have been described in the art (see e.g., Laping et al. (2002) Mol. Pharmacol. 2002; 62: 58-62). The compounds named in th...


US Patent US9938289 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM172454
PNG
(US9090625, 6 | US9260450, 6 | US9938289, 6)
Show SMILES Cc1nn(c(c1C)-c1cc2cnccc2s1)-c1cccc(C)n1
Show InChI InChI=1S/C18H16N4S/c1-11-5-4-6-17(20-11)22-18(12(2)13(3)21-22)16-9-14-10-19-8-7-15(14)23-16/h4-10H,1-3H3
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US Patent
n/an/a 35.2n/an/an/an/an/an/a



FBM THERAPEUTICS, LLC

US Patent


Assay Description
ALK-5 kinase assay methods have been described in the art (see e.g., Laping et al. (2002) Mol. Pharmacol. 2002; 62: 58-62). The compounds named in th...


US Patent US9938289 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM172450
PNG
(US9090625, 2 | US9260450, 2 | US9938289, 2)
Show SMILES Cc1cc(-c2cc3cnccc3s2)n(n1)-c1cccc(C)n1
Show InChI InChI=1S/C17H14N4S/c1-11-4-3-5-17(19-11)21-14(8-12(2)20-21)16-9-13-10-18-7-6-15(13)22-16/h3-10H,1-2H3
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US Patent
n/an/a 93.9n/an/an/an/an/an/a



FBM THERAPEUTICS, LLC

US Patent


Assay Description
ALK-5 kinase assay methods have been described in the art (see e.g., Laping et al. (2002) Mol. Pharmacol. 2002; 62: 58-62). The compounds named in th...


US Patent US9938289 (2018)

More data for this
Ligand-Target Pair
TGF-beta receptor type I


(Homo sapiens (Human))
BDBM172451
PNG
(US9090625, 3 | US9260450, 3 | US9938289, 3)
Show SMILES CCc1cc(-c2cc3cnccc3s2)n(n1)-c1cccc(C)n1
Show InChI InChI=1S/C18H16N4S/c1-3-14-10-15(17-9-13-11-19-8-7-16(13)23-17)22(21-14)18-6-4-5-12(2)20-18/h4-11H,3H2,1-2H3
PDB

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B.MOAD
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PC sid
UniChem

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US Patent
n/an/a 108n/an/an/an/an/an/a



FBM THERAPEUTICS, LLC

US Patent


Assay Description
ALK-5 kinase assay methods have been described in the art (see e.g., Laping et al. (2002) Mol. Pharmacol. 2002; 62: 58-62). The compounds named in th...


US Patent US9938289 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%