BindingDB logo
myBDB logout

Patent code US9944645

Compile Data Set for Download or QSAR

Found 205 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388647
PNG
(2-(4-Fluorophenyl)-7-(4-methoxybenzyl)imidazo[1,2-...)
Show SMILES COc1ccc(Cc2cnc3ncc(nn23)-c2ccc(F)cc2)cc1
Show InChI InChI=1S/C19H15FN4O/c1-25-17-8-2-13(3-9-17)10-16-11-21-19-22-12-18(23-24(16)19)14-4-6-15(20)7-5-14/h2-9,11-12H,10H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM50146167
PNG
(CAPMATINIB | Capmatinib | INC-280 | INCB-28060 | N...)
Show SMILES CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C23H17FN6O/c1-25-22(31)18-6-5-16(11-19(18)24)21-13-28-23-27-12-17(30(23)29-21)10-14-4-7-20-15(9-14)3-2-8-26-20/h2-9,11-13H,10H2,1H3,(H,25,31)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388656
PNG
(2-chloro-4-3-[(4-methoxyphenyl)thio]imidazo[1,2-a]...)
Show SMILES CNC(=O)c1ccc(cc1Cl)-c1cnc2ncc(Sc3ccc(OC)cc3)n2c1
Show InChI InChI=1S/C21H17ClN4O2S/c1-23-20(27)17-8-3-13(9-18(17)22)14-10-24-21-25-11-19(26(21)12-14)29-16-6-4-15(28-2)5-7-16/h3-12H,1-2H3,(H,23,27)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388684
PNG
(2-Fluoro-N-methyl-4-[3-(1-quinolin-6-ylcyclopropyl...)
Show SMILES CNC(=O)c1ccc(cc1F)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C26H20FN5O/c1-28-24(33)20-6-4-16(12-21(20)27)18-13-30-25-31-14-23(32(25)15-18)26(8-9-26)19-5-7-22-17(11-19)3-2-10-29-22/h2-7,10-15H,8-9H2,1H3,(H,28,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388688
PNG
(6-(1-{6-[3-Fluoro-4-(1-methyl-2-oxo-2-pyrrolidin-1...)
Show SMILES CC(Oc1ccc(cc1F)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1)C(=O)N1CCCC1
Show InChI InChI=1S/C31H28FN5O2/c1-20(29(38)36-13-2-3-14-36)39-27-9-6-21(16-25(27)32)23-17-34-30-35-18-28(37(30)19-23)31(10-11-31)24-7-8-26-22(15-24)5-4-12-33-26/h4-9,12,15-20H,2-3,10-11,13-14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388695
PNG
(N-[1-(4-Methyl-1,3-thiazol-2-yl)ethyl]-1-[3-(1-qui...)
Show SMILES CC(NC(=O)c1cnn(c1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1)c1nc(C)cs1
Show InChI InChI=1S/C28H24N8OS/c1-17-16-38-26(33-17)18(2)34-25(37)20-11-32-36(14-20)22-12-30-27-31-13-24(35(27)15-22)28(7-8-28)21-5-6-23-19(10-21)4-3-9-29-23/h3-6,9-16,18H,7-8H2,1-2H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388703
PNG
(N-(1-Pyridin-2-ylpiperidin-4-yl)-4-[3-(1-quinolin-...)
Show SMILES O=C(NC1CCN(CC1)c1ccccn1)c1ccc(cc1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C35H31N7O/c43-33(40-29-12-18-41(19-13-29)32-5-1-2-16-37-32)25-8-6-24(7-9-25)27-21-38-34-39-22-31(42(34)23-27)35(14-15-35)28-10-11-30-26(20-28)4-3-17-36-30/h1-11,16-17,20-23,29H,12-15,18-19H2,(H,40,43)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388711
PNG
(N-[1-Methyl-2-(pyridin-2-yloxy)ethyl]-4-[3-(1-quin...)
Show SMILES CC(COc1ccccn1)NC(=O)c1ccc(cc1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C33H28N6O2/c1-22(21-41-30-6-2-3-15-35-30)38-31(40)24-9-7-23(8-10-24)26-18-36-32-37-19-29(39(32)20-26)33(13-14-33)27-11-12-28-25(17-27)5-4-16-34-28/h2-12,15-20,22H,13-14,21H2,1H3,(H,38,40)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388719
PNG
(N-Methyl-3-[3-(1-quinolin-6-ylcyclopropyl)imidazo[...)
Show SMILES CNC(=O)c1cccc(c1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C26H21N5O/c1-27-24(32)19-5-2-4-17(12-19)20-14-29-25-30-15-23(31(25)16-20)26(9-10-26)21-7-8-22-18(13-21)6-3-11-28-22/h2-8,11-16H,9-10H2,1H3,(H,27,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388720
PNG
(N-[(1S)-1-Methyl-2-(methylamino)-2-oxoethyl]-4-[3-...)
Show SMILES CNC(=O)[C@H](C)NC(=O)c1ccc(cc1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C29H26N6O2/c1-18(26(36)30-2)34-27(37)20-7-5-19(6-8-20)22-15-32-28-33-16-25(35(28)17-22)29(11-12-29)23-9-10-24-21(14-23)4-3-13-31-24/h3-10,13-18H,11-12H2,1-2H3,(H,30,36)(H,34,37)/t18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388722
PNG
((3R)-1-{4-[3-(1-Quinolin-6-ylcyclopropyl)imidazo[1...)
Show SMILES O=C(N1CC[C@@H](C1)C#N)c1ccc(cc1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C30H24N6O/c31-15-20-9-13-35(18-20)28(37)22-5-3-21(4-6-22)24-16-33-29-34-17-27(36(29)19-24)30(10-11-30)25-7-8-26-23(14-25)2-1-12-32-26/h1-8,12,14,16-17,19-20H,9-11,13,18H2/t20-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388731
PNG
(N-[(1S)-2-(Dimethylamino)-1-methyl-2-oxoethyl]-5-[...)
Show SMILES C[C@H](NC(=O)c1ccc(cn1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1)C(=O)N(C)C
Show InChI InChI=1S/C29H27N7O2/c1-18(27(38)35(2)3)34-26(37)24-8-6-20(14-31-24)21-15-32-28-33-16-25(36(28)17-21)29(10-11-29)22-7-9-23-19(13-22)5-4-12-30-23/h4-9,12-18H,10-11H2,1-3H3,(H,34,37)/t18-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388772
PNG
(2-Fluoro-N-methyl-4-[7-(1-quinolin-6-ylcyclopropyl...)
Show SMILES CNC(=O)c1ccc(cc1F)-c1cnc2ncc(n2n1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C25H19FN6O/c1-27-23(33)18-6-4-16(12-19(18)26)21-13-29-24-30-14-22(32(24)31-21)25(8-9-25)17-5-7-20-15(11-17)3-2-10-28-20/h2-7,10-14H,8-9H2,1H3,(H,27,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388774
PNG
(2-Fluoro-4-(7-(1-(quinolin-6-yl)cyclopropyl)imidaz...)
Show SMILES NC(=O)c1ccc(cc1F)-c1cnc2ncc(n2n1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C24H17FN6O/c25-18-11-15(3-5-17(18)22(26)32)20-12-28-23-29-13-21(31(23)30-20)24(7-8-24)16-4-6-19-14(10-16)2-1-9-27-19/h1-6,9-13H,7-8H2,(H2,26,32)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388782
PNG
((3R)-1-{4-[7-(1-quinolin-6-ylcyclopropyl)imidazo[1...)
Show SMILES O[C@@H]1CCN(C1)C(=O)c1ccc(cc1)-c1cnc2ncc(n2n1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C28H24N6O2/c35-22-9-13-33(17-22)26(36)19-5-3-18(4-6-19)24-15-30-27-31-16-25(34(27)32-24)28(10-11-28)21-7-8-23-20(14-21)2-1-12-29-23/h1-8,12,14-16,22,35H,9-11,13,17H2/t22-/m1/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388788
PNG
(N-[4-(Methoxymethyl)tetrahydro-2H-pyran-4-yl]-4-[7...)
Show SMILES COCC1(CCOCC1)NC(=O)c1ccc(cc1)-c1cnc2ncc(n2n1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C31H30N6O3/c1-39-20-30(12-15-40-16-13-30)35-28(38)22-6-4-21(5-7-22)26-18-33-29-34-19-27(37(29)36-26)31(10-11-31)24-8-9-25-23(17-24)3-2-14-32-25/h2-9,14,17-19H,10-13,15-16,20H2,1H3,(H,35,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388810
PNG
(2-{4-[7-(Quinolin-6-ylmethyl)imidazo[1,2-b][1,2,4]...)
Show SMILES NC(=O)Cn1cc(cn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C20H16N8O/c21-19(29)12-27-11-15(8-25-27)18-10-24-20-23-9-16(28(20)26-18)7-13-3-4-17-14(6-13)2-1-5-22-17/h1-6,8-11H,7,12H2,(H2,21,29)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388812
PNG
(2-Fluoro-N-[(1S,2S)-2-hydroxycyclopentyl]-4-[7-(qu...)
Show SMILES O[C@H]1CCC[C@@H]1NC(=O)c1ccc(cc1F)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C27H23FN6O2/c28-21-13-18(7-8-20(21)26(36)32-23-4-1-5-25(23)35)24-15-31-27-30-14-19(34(27)33-24)12-16-6-9-22-17(11-16)3-2-10-29-22/h2-3,6-11,13-15,23,25,35H,1,4-5,12H2,(H,32,36)/t23-,25-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388817
PNG
(2-Fluoro-4-[7-(quinolin-6-ylmethyl)imidazo[1,2-b][...)
Show SMILES Fc1cc(ccc1C(=O)NCC1CCOCC1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C28H25FN6O2/c29-24-14-21(4-5-23(24)27(36)31-15-18-7-10-37-11-8-18)26-17-33-28-32-16-22(35(28)34-26)13-19-3-6-25-20(12-19)2-1-9-30-25/h1-6,9,12,14,16-18H,7-8,10-11,13,15H2,(H,31,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388833
PNG
(2-Fluoro-N-(2-methoxy-1-methylethyl)-4-[3-(1-quino...)
Show SMILES COCC(C)NC(=O)c1ccc(cc1F)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C29H26FN5O2/c1-18(17-37-2)34-27(36)23-7-5-19(13-24(23)30)21-14-32-28-33-15-26(35(28)16-21)29(9-10-29)22-6-8-25-20(12-22)4-3-11-31-25/h3-8,11-16,18H,9-10,17H2,1-2H3,(H,34,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388848
PNG
(6-(1-{6-[4-(Azetidin-1-ylcarbonyl)-3-chlorophenyl]...)
Show SMILES Clc1cc(ccc1C(=O)N1CCC1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C28H22ClN5O/c29-23-14-18(4-6-22(23)26(35)33-11-2-12-33)20-15-31-27-32-16-25(34(27)17-20)28(8-9-28)21-5-7-24-19(13-21)3-1-10-30-24/h1,3-7,10,13-17H,2,8-9,11-12H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388852
PNG
(2-Cyclopropyl-5-[3-(1-quinolin-6-ylcyclopropyl)imi...)
Show SMILES O=C1N(Cc2cc(ccc12)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1)C1CC1
Show InChI InChI=1S/C29H23N5O/c35-27-24-7-3-18(12-20(24)16-33(27)23-5-6-23)21-14-31-28-32-15-26(34(28)17-21)29(9-10-29)22-4-8-25-19(13-22)2-1-11-30-25/h1-4,7-8,11-15,17,23H,5-6,9-10,16H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388866
PNG
(2-Fluoro-N-methyl-4-[3-(1-quinolin-6-ylcyclopropyl...)
Show SMILES CNS(=O)(=O)c1ccc(cc1F)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C25H20FN5O2S/c1-27-34(32,33)22-7-4-16(12-20(22)26)18-13-29-24-30-14-23(31(24)15-18)25(8-9-25)19-5-6-21-17(11-19)3-2-10-28-21/h2-7,10-15,27H,8-9H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388873
PNG
(Methyl 4-(cyanomethyl)-4-{4-[7-(quinolin-6-ylmethy...)
Show SMILES COC(=O)N1CCC(CC#N)(CC1)n1cc(cn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C27H25N9O2/c1-38-26(37)34-11-7-27(6-9-28,8-12-34)35-18-21(15-32-35)24-17-31-25-30-16-22(36(25)33-24)14-19-4-5-23-20(13-19)3-2-10-29-23/h2-5,10,13,15-18H,6-8,11-12,14H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388657
PNG
(2-Fluoro-N-methyl-4-[3-(quinolin-6-ylthio)imidazo[...)
Show SMILES CNC(=O)c1ccc(cc1F)-c1cnc2ncc(Sc3ccc4ncccc4c3)n2c1
Show InChI InChI=1S/C23H16FN5OS/c1-25-22(30)18-6-4-14(10-19(18)24)16-11-27-23-28-12-21(29(23)13-16)31-17-5-7-20-15(9-17)3-2-8-26-20/h2-13H,1H3,(H,25,30)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388693
PNG
(6-{1-[6-(4-Methyl-1H-pyrazol-1-yl)imidazo[1,2-a]py...)
Show SMILES Cc1cnn(c1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C22H18N6/c1-15-10-26-28(13-15)18-11-24-21-25-12-20(27(21)14-18)22(6-7-22)17-4-5-19-16(9-17)3-2-8-23-19/h2-5,8-14H,6-7H2,1H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388694
PNG
(N,N-Dimethyl-1-[3-(1-quinolin-6-ylcyclopropyl)imid...)
Show SMILES CN(C)C(=O)c1cnn(c1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C24H21N7O/c1-29(2)22(32)17-11-28-31(14-17)19-12-26-23-27-13-21(30(23)15-19)24(7-8-24)18-5-6-20-16(10-18)4-3-9-25-20/h3-6,9-15H,7-8H2,1-2H3
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388704
PNG
(N-(1-Pyridin-2-ylethyl)-4-[3-(1-quinolin-6-ylcyclo...)
Show SMILES CC(NC(=O)c1ccc(cc1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1)c1ccccn1
Show InChI InChI=1S/C32H26N6O/c1-21(27-6-2-3-15-33-27)37-30(39)23-9-7-22(8-10-23)25-18-35-31-36-19-29(38(31)20-25)32(13-14-32)26-11-12-28-24(17-26)5-4-16-34-28/h2-12,15-21H,13-14H2,1H3,(H,37,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388706
PNG
(N-[1-(Methoxymethyl)cyclobutyl]-4-[3-(1-quinolin-6...)
Show SMILES COCC1(CCC1)NC(=O)c1ccc(cc1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C31H29N5O2/c1-38-20-30(11-3-12-30)35-28(37)22-7-5-21(6-8-22)24-17-33-29-34-18-27(36(29)19-24)31(13-14-31)25-9-10-26-23(16-25)4-2-15-32-26/h2,4-10,15-19H,3,11-14,20H2,1H3,(H,35,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388708
PNG
(6-[1-(6-{4-[(3-Pyridin-2-ylpyrrolidin-1-yl)carbony...)
Show SMILES O=C(N1CCC(C1)c1ccccn1)c1ccc(cc1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C34H28N6O/c41-32(39-17-12-26(21-39)29-5-1-2-15-35-29)24-8-6-23(7-9-24)27-19-37-33-38-20-31(40(33)22-27)34(13-14-34)28-10-11-30-25(18-28)4-3-16-36-30/h1-11,15-16,18-20,22,26H,12-14,17,21H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388710
PNG
(N-[2-(Pyridin-2-yloxy)ethyl]-4-[3-(1-quinolin-6-yl...)
Show SMILES O=C(NCCOc1ccccn1)c1ccc(cc1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C32H26N6O2/c39-30(35-16-17-40-29-5-1-2-14-34-29)23-8-6-22(7-9-23)25-19-36-31-37-20-28(38(31)21-25)32(12-13-32)26-10-11-27-24(18-26)4-3-15-33-27/h1-11,14-15,18-21H,12-13,16-17H2,(H,35,39)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388716
PNG
(N-Cyclopropyl-3-[3-(1-quinolin-6-ylcyclopropyl)imi...)
Show SMILES O=C(NC1CC1)c1cccc(c1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C28H23N5O/c34-26(32-23-7-8-23)20-4-1-3-18(13-20)21-15-30-27-31-16-25(33(27)17-21)28(10-11-28)22-6-9-24-19(14-22)5-2-12-29-24/h1-6,9,12-17,23H,7-8,10-11H2,(H,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388736
PNG
(Methyl 2-fluoro-4-[3-(1-quinolin-6-ylcyclopropyl)i...)
Show SMILES COC(=O)NCc1ccc(cc1F)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C27H22FN5O2/c1-35-26(34)32-13-19-5-4-17(12-22(19)28)20-14-30-25-31-15-24(33(25)16-20)27(8-9-27)21-6-7-23-18(11-21)3-2-10-29-23/h2-7,10-12,14-16H,8-9,13H2,1H3,(H,32,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388750
PNG
(2,5-Difluoro-N-(trans-4-hydroxycyclohexyl)-4-[3-(1...)
Show SMILES O[C@H]1CCC(CC1)NC(=O)c1cc(F)c(cc1F)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C31H27F2N5O2/c32-25-14-24(29(40)37-21-4-6-22(39)7-5-21)26(33)13-23(25)19-15-35-30-36-16-28(38(30)17-19)31(9-10-31)20-3-8-27-18(12-20)2-1-11-34-27/h1-3,8,11-17,21-22,39H,4-7,9-10H2,(H,37,40)/t21?,22-
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388752
PNG
(3-{2-Fluoro-4-[3-(1-quinolin-6-ylcyclopropyl)imida...)
Show SMILES Fc1cc(ccc1N1CCOC1=O)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C27H20FN5O2/c28-21-13-17(3-6-23(21)32-10-11-35-26(32)34)19-14-30-25-31-15-24(33(25)16-19)27(7-8-27)20-4-5-22-18(12-20)2-1-9-29-22/h1-6,9,12-16H,7-8,10-11H2
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388764
PNG
(N-Methyl-5-{4-[7-(1-quinolin-6-ylcyclopropyl)imida...)
Show SMILES CNC(=O)c1ccc(cn1)-c1ccc(cc1)-c1cnc2ncc(n2n1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C30H23N7O/c1-31-28(38)25-10-8-22(16-33-25)19-4-6-20(7-5-19)26-17-34-29-35-18-27(37(29)36-26)30(12-13-30)23-9-11-24-21(15-23)3-2-14-32-24/h2-11,14-18H,12-13H2,1H3,(H,31,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388770
PNG
(2-Fluoro-N-(trans-4-hydroxycyclohexyl)-4-[7-(1-qui...)
Show SMILES O[C@H]1CC[C@@H](CC1)NC(=O)c1ccc(cc1F)-c1cnc2ncc(n2n1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C30H27FN6O2/c31-24-15-19(3-9-23(24)28(39)35-21-5-7-22(38)8-6-21)26-16-33-29-34-17-27(37(29)36-26)30(11-12-30)20-4-10-25-18(14-20)2-1-13-32-25/h1-4,9-10,13-17,21-22,38H,5-8,11-12H2,(H,35,39)/t21-,22-
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388773
PNG
(2-Fluoro-N-[1-(methoxymethyl)cyclopropyl]-4-[7-(1-...)
Show SMILES COCC1(CC1)NC(=O)c1ccc(cc1F)-c1cnc2ncc(n2n1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C29H25FN6O2/c1-38-17-28(8-9-28)34-26(37)21-6-4-19(14-22(21)30)24-15-32-27-33-16-25(36(27)35-24)29(10-11-29)20-5-7-23-18(13-20)3-2-12-31-23/h2-7,12-16H,8-11,17H2,1H3,(H,34,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388790
PNG
(N-Pyrimidin-4-yl-4-[7-(1-quinolin-6-ylcyclopropyl)...)
Show SMILES Fc1cc(ccc1C(=O)Nc1ccncn1)-c1cnc2ncc(n2n1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C28H19FN8O/c29-21-13-18(3-5-20(21)26(38)35-25-7-11-30-16-34-25)23-14-32-27-33-15-24(37(27)36-23)28(8-9-28)19-4-6-22-17(12-19)2-1-10-31-22/h1-7,10-16H,8-9H2,(H,30,34,35,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388821
PNG
(2-Fluoro-N-(pyridin-2-ylmethyl)-4-[7-(quinolin-6-y...)
Show SMILES Fc1cc(ccc1C(=O)NCc1ccccn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C28H20FN7O/c29-24-14-20(7-8-23(24)27(37)32-15-21-5-1-2-10-30-21)26-17-34-28-33-16-22(36(28)35-26)13-18-6-9-25-19(12-18)4-3-11-31-25/h1-12,14,16-17H,13,15H2,(H,32,37)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388824
PNG
(2-Fluoro-N-(2-pyridin-2-ylethyl)-4-[7-(quinolin-6-...)
Show SMILES Fc1cc(ccc1C(=O)NCCc1ccccn1)-c1cnc2ncc(Cc3ccc4ncccc4c3)n2n1
Show InChI InChI=1S/C29H22FN7O/c30-25-16-21(7-8-24(25)28(38)33-13-10-22-5-1-2-11-31-22)27-18-35-29-34-17-23(37(29)36-27)15-19-6-9-26-20(14-19)4-3-12-32-26/h1-9,11-12,14,16-18H,10,13,15H2,(H,33,38)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388829
PNG
(2-Fluoro-N-(trans-4-hydroxycyclohexyl)-4-[7-(1-qui...)
Show SMILES CC(c1cnc2ncc(nn12)-c1ccc(C(=O)N[C@H]2CC[C@H](O)CC2)c(F)c1)c1ccc2ncccc2c1
Show InChI InChI=1S/C29H27FN6O2/c1-17(18-5-11-25-19(13-18)3-2-12-31-25)27-16-33-29-32-15-26(35-36(27)29)20-4-10-23(24(30)14-20)28(38)34-21-6-8-22(37)9-7-21/h2-5,10-17,21-22,37H,6-9H2,1H3,(H,34,38)/t17?,21-,22-
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388834
PNG
(6-{1-[6-(3-Fluoro-4-[(3S)-3-fluoropyrrolidin-1-yl]...)
Show SMILES F[C@H]1CCN(C1)C(=O)c1ccc(cc1F)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C29H23F2N5O/c30-22-7-11-35(17-22)27(37)23-5-3-18(13-24(23)31)20-14-33-28-34-15-26(36(28)16-20)29(8-9-29)21-4-6-25-19(12-21)2-1-10-32-25/h1-6,10,12-16,22H,7-9,11,17H2/t22-/m0/s1
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388836
PNG
(2-Fluoro-N-(1-pyridin-2-ylcyclopropyl)-4-[3-(1-qui...)
Show SMILES Fc1cc(ccc1C(=O)NC1(CC1)c1ccccn1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C33H25FN6O/c34-26-17-21(6-8-25(26)30(41)39-33(12-13-33)28-5-1-2-14-36-28)23-18-37-31-38-19-29(40(31)20-23)32(10-11-32)24-7-9-27-22(16-24)4-3-15-35-27/h1-9,14-20H,10-13H2,(H,39,41)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388844
PNG
(2-Chloro-N-methyl-4-[3-(1-quinolin-6-ylcyclopropyl...)
Show SMILES CNC(=O)c1ccc(cc1Cl)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C26H20ClN5O/c1-28-24(33)20-6-4-16(12-21(20)27)18-13-30-25-31-14-23(32(25)15-18)26(8-9-26)19-5-7-22-17(11-19)3-2-10-29-22/h2-7,10-15H,8-9H2,1H3,(H,28,33)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388846
PNG
(2-Chloro-4-[3-(1-quinolin-6-ylcyclopropyl)imidazo[...)
Show SMILES Clc1cc(ccc1C(=O)NC1CCOC1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C29H24ClN5O2/c30-24-13-18(3-5-23(24)27(36)34-22-7-11-37-17-22)20-14-32-28-33-15-26(35(28)16-20)29(8-9-29)21-4-6-25-19(12-21)2-1-10-31-25/h1-6,10,12-16,22H,7-9,11,17H2,(H,34,36)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388847
PNG
(2-Chloro-N-(1-pyridin-2-ylethyl)-4-[3-(1-quinolin-...)
Show SMILES CC(NC(=O)c1ccc(cc1Cl)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1)c1ccccn1
Show InChI InChI=1S/C32H25ClN6O/c1-20(27-6-2-3-13-34-27)38-30(40)25-9-7-21(16-26(25)33)23-17-36-31-37-18-29(39(31)19-23)32(11-12-32)24-8-10-28-22(15-24)5-4-14-35-28/h2-10,13-20H,11-12H2,1H3,(H,38,40)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388850
PNG
(2-Chloro-N-[1-methyl-2-(pyridin-2-yloxy)ethyl]-4-[...)
Show SMILES CC(COc1ccccn1)NC(=O)c1ccc(cc1Cl)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C33H27ClN6O2/c1-21(20-42-30-6-2-3-13-36-30)39-31(41)26-9-7-22(16-27(26)34)24-17-37-32-38-18-29(40(32)19-24)33(11-12-33)25-8-10-28-23(15-25)5-4-14-35-28/h2-10,13-19,21H,11-12,20H2,1H3,(H,39,41)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388858
PNG
(N-(1-Pyridin-2-ylethyl)-1-{4-[3-(1-quinolin-6-ylcy...)
Show SMILES CC(NC(=O)C1(CC1)c1ccc(cc1)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1)c1ccccn1
Show InChI InChI=1S/C35H30N6O/c1-23(29-6-2-3-17-36-29)40-32(42)35(15-16-35)27-9-7-24(8-10-27)26-20-38-33-39-21-31(41(33)22-26)34(13-14-34)28-11-12-30-25(19-28)5-4-18-37-30/h2-12,17-23H,13-16H2,1H3,(H,40,42)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Hepatocyte growth factor receptor


(Homo sapiens (Human))
BDBM388864
PNG
(2,3-Difluoro-N-methyl-4-[3-(1-quinolin-6-ylcyclopr...)
Show SMILES CNC(=O)c1ccc(c(F)c1F)-c1cnc2ncc(n2c1)C1(CC1)c1ccc2ncccc2c1
Show InChI InChI=1S/C26H19F2N5O/c1-29-24(34)19-6-5-18(22(27)23(19)28)16-12-31-25-32-13-21(33(25)14-16)26(8-9-26)17-4-7-20-15(11-17)3-2-10-30-20/h2-7,10-14H,8-9H2,1H3,(H,29,34)
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<500n/an/an/an/an/an/a



Incyte Corporation; Incyte Holdings Corporation

US Patent


Assay Description
Compounds were screened in vitro for their ability to inhibit c-Met kinase activity. The IC50 values of compounds for the inhibition of c-Met kinase ...


US Patent US9944645 (2018)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 205 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%