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Patent code US9951029

Compile Data Set for Download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389576
PNG
(N-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quinaz...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN)c3cc(Br)ccc3n2)cc1
Show InChI InChI=1S/C20H21BrN4O/c1-26-16-7-3-14(4-8-16)5-10-19-24-18-9-6-15(21)13-17(18)20(25-19)23-12-2-11-22/h3-10,13H,2,11-12,22H2,1H3,(H,23,24,25)/b10-5+
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 74n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389583
PNG
(N-{2-[(E)-2-(4- methoxyphenyl)vinyl]quinazolin-4- ...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN)c3ccccc3n2)cc1
Show InChI InChI=1S/C20H22N4O/c1-25-16-10-7-15(8-11-16)9-12-19-23-18-6-3-2-5-17(18)20(24-19)22-14-4-13-21/h2-3,5-12H,4,13-14,21H2,1H3,(H,22,23,24)/b12-9+
PDB
MMDB

KEGG

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/a 134n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389615
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H23ClN4O2S/c1-26(2)13-12-23-21-18-14-16(22)7-10-19(18)24-20(25-21)11-6-15-4-8-17(9-5-15)29(3,27)28/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)/b11-6+
PDB
MMDB

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PC cid
PC sid
UniChem
US Patent
n/an/a 246n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389591
PNG
(N'-{2-[(E)-2-(4- isopropylphenyl)vinyl]quinazolin-...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCN(C)C)c3ccccc3n2)cc1
Show InChI InChI=1S/C23H28N4/c1-17(2)19-12-9-18(10-13-19)11-14-22-25-21-8-6-5-7-20(21)23(26-22)24-15-16-27(3)4/h5-14,17H,15-16H2,1-4H3,(H,24,25,26)/b14-11+
PDB
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KEGG

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UniChem
US Patent
n/an/a 258n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389604
PNG
(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylsulfonyl)phen...)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccccc12
Show InChI InChI=1S/C21H24N4O2S/c1-25(2)15-14-22-21-18-6-4-5-7-19(18)23-20(24-21)13-10-16-8-11-17(12-9-16)28(3,26)27/h4-13H,14-15H2,1-3H3,(H,22,23,24)/b13-10+
PDB
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UniChem
US Patent
n/an/a 326n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389608
PNG
(N'-{6-chloro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCN(C)C)c3cc(Cl)ccc3n2)cc1
Show InChI InChI=1S/C23H27ClN4/c1-16(2)18-8-5-17(6-9-18)7-12-22-26-21-11-10-19(24)15-20(21)23(27-22)25-13-14-28(3)4/h5-12,15-16H,13-14H2,1-4H3,(H,25,26,27)/b12-7+
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n/an/a 412n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389616
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12
Show InChI InChI=1S/C23H27ClN4O2S/c1-4-28(5-2)15-14-25-23-20-16-18(24)9-12-21(20)26-22(27-23)13-8-17-6-10-19(11-7-17)31(3,29)30/h6-13,16H,4-5,14-15H2,1-3H3,(H,25,26,27)/b13-8+
PDB
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n/an/a 440n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389586
PNG
(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...)
Show SMILES CSc1ccc(\C=C\c2nc(NCCN(C)C)c3ccccc3n2)cc1
Show InChI InChI=1S/C21H24N4S/c1-25(2)15-14-22-21-18-6-4-5-7-19(18)23-20(24-21)13-10-16-8-11-17(26-3)12-9-16/h4-13H,14-15H2,1-3H3,(H,22,23,24)/b13-10+
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n/an/a 461n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389611
PNG
(N'-{6-fluoro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCN(C)C)c3cc(F)ccc3n2)cc1
Show InChI InChI=1S/C23H27FN4/c1-16(2)18-8-5-17(6-9-18)7-12-22-26-21-11-10-19(24)15-20(21)23(27-22)25-13-14-28(3)4/h5-12,15-16H,13-14H2,1-4H3,(H,25,26,27)/b12-7+
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n/an/a 582n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389574
PNG
(N'-{2-[(E)-2-(4- fluorophenyl)vinyl]quinazolin-4-y...)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(F)cc2)nc2ccccc12
Show InChI InChI=1S/C20H21FN4/c1-25(2)14-13-22-20-17-5-3-4-6-18(17)23-19(24-20)12-9-15-7-10-16(21)11-8-15/h3-12H,13-14H2,1-2H3,(H,22,23,24)/b12-9+
PDB
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UniChem
US Patent
n/an/a 811n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389613
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12
Show InChI InChI=1S/C22H25ClN4O2S/c1-27(2)14-4-13-24-22-19-15-17(23)8-11-20(19)25-21(26-22)12-7-16-5-9-18(10-6-16)30(3,28)29/h5-12,15H,4,13-14H2,1-3H3,(H,24,25,26)/b12-7+
PDB
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PC cid
PC sid
UniChem
US Patent
n/an/a 873n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389612
PNG
(N,N-diethyl-N'-{6-fluoro-2-[(E)-2-(4- isopropylphe...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(cc2)C(C)C)nc2ccc(F)cc12
Show InChI InChI=1S/C25H31FN4/c1-5-30(6-2)16-15-27-25-22-17-21(26)12-13-23(22)28-24(29-25)14-9-19-7-10-20(11-8-19)18(3)4/h7-14,17-18H,5-6,15-16H2,1-4H3,(H,27,28,29)/b14-9+
PDB
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UniChem
US Patent
n/an/a 874n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389585
PNG
(N,N-dimethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]benzo[...)
Show SMILES CN(C)CCNc1nc(\C=C\c2cccs2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C22H22N4S/c1-26(2)12-11-23-22-19-14-16-6-3-4-7-17(16)15-20(19)24-21(25-22)10-9-18-8-5-13-27-18/h3-10,13-15H,11-12H2,1-2H3,(H,23,24,25)/b10-9+
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n/an/a 950n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389610
PNG
(N'-{6-fluoro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(F)ccc3n2)cc1
Show InChI InChI=1S/C24H29FN4/c1-17(2)19-9-6-18(7-10-19)8-13-23-27-22-12-11-20(25)16-21(22)24(28-23)26-14-5-15-29(3)4/h6-13,16-17H,5,14-15H2,1-4H3,(H,26,27,28)/b13-8+
PDB
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UniChem
US Patent
n/an/a 1.26E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389602
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylthio)phenyl]vinyl...)
Show SMILES CSc1ccc(\C=C\c2nc(NCCN(C)C)c3cc(Cl)ccc3n2)cc1
Show InChI InChI=1S/C21H23ClN4S/c1-26(2)13-12-23-21-18-14-16(22)7-10-19(18)24-20(25-21)11-6-15-4-8-17(27-3)9-5-15/h4-11,14H,12-13H2,1-3H3,(H,23,24,25)/b11-6+
PDB
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PC sid
UniChem
US Patent
n/an/a 1.26E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389606
PNG
(N'-{6-chloro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(Cl)ccc3n2)cc1
Show InChI InChI=1S/C24H29ClN4/c1-17(2)19-9-6-18(7-10-19)8-13-23-27-22-12-11-20(25)16-21(22)24(28-23)26-14-5-15-29(3)4/h6-13,16-17H,5,14-15H2,1-4H3,(H,26,27,28)/b13-8+
PDB
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UniChem
US Patent
n/an/a 1.27E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389559
PNG
(N'-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quina...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(Br)ccc3n2)cc1
Show InChI InChI=1S/C22H25BrN4O/c1-27(2)14-4-13-24-22-19-15-17(23)8-11-20(19)25-21(26-22)12-7-16-5-9-18(28-3)10-6-16/h5-12,15H,4,13-14H2,1-3H3,(H,24,25,26)/b12-7+
PDB
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n/an/a 1.39E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389609
PNG
(N'-{6-chloro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(cc2)C(C)C)nc2ccc(Cl)cc12
Show InChI InChI=1S/C25H31ClN4/c1-5-30(6-2)16-15-27-25-22-17-21(26)12-13-23(22)28-24(29-25)14-9-19-7-10-20(11-8-19)18(3)4/h7-14,17-18H,5-6,15-16H2,1-4H3,(H,27,28,29)/b14-9+
PDB
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UniChem
US Patent
n/an/a 1.40E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389558
PNG
(N'-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quina...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(F)ccc3n2)cc1
Show InChI InChI=1S/C22H25FN4O/c1-27(2)14-4-13-24-22-19-15-17(23)8-11-20(19)25-21(26-22)12-7-16-5-9-18(28-3)10-6-16/h5-12,15H,4,13-14H2,1-3H3,(H,24,25,26)/b12-7+
PDB
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UniChem
US Patent
n/an/a 1.42E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389590
PNG
(N,N-diethyl-N'-{2-[(E)-2-(4- isopropylphenyl)vinyl...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(cc2)C(C)C)nc2ccccc12
Show InChI InChI=1S/C26H34N4/c1-5-30(6-2)19-9-18-27-26-23-10-7-8-11-24(23)28-25(29-26)17-14-21-12-15-22(16-13-21)20(3)4/h7-8,10-17,20H,5-6,9,18-19H2,1-4H3,(H,27,28,29)/b17-14+
PDB
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UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 1.51E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389603
PNG
(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylsulfonyl)phen...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccccc12
Show InChI InChI=1S/C22H26N4O2S/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(13-10-17)29(3,27)28/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25)/b14-11+
PDB
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n/an/a 1.51E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389562
PNG
(N'-{6-bromo-2-[(E)-2-(4- fluorophenyl)vinyl]quinaz...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(Br)cc12
Show InChI InChI=1S/C21H22BrFN4/c1-27(2)13-3-12-24-21-18-14-16(22)7-10-19(18)25-20(26-21)11-6-15-4-8-17(23)9-5-15/h4-11,14H,3,12-13H2,1-2H3,(H,24,25,26)/b11-6+
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n/an/a 1.55E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389582
PNG
(N,N-dimethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]benzo[...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2cccs2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C23H24N4S/c1-27(2)13-6-12-24-23-20-15-17-7-3-4-8-18(17)16-21(20)25-22(26-23)11-10-19-9-5-14-28-19/h3-5,7-11,14-16H,6,12-13H2,1-2H3,(H,24,25,26)/b11-10+
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n/an/a 1.64E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389581
PNG
(N'-{6-chloro-2-[(E)-2-(3,4- difluorophenyl)vinyl]q...)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(F)c(F)c2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C20H19ClF2N4/c1-27(2)10-9-24-20-15-12-14(21)5-7-18(15)25-19(26-20)8-4-13-3-6-16(22)17(23)11-13/h3-8,11-12H,9-10H2,1-2H3,(H,24,25,26)/b8-4+
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n/an/a 1.70E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389578
PNG
(N,N-diethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]vi...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(SC)cc2)nc2ccccc12
Show InChI InChI=1S/C23H28N4S/c1-4-27(5-2)17-16-24-23-20-8-6-7-9-21(20)25-22(26-23)15-12-18-10-13-19(28-3)14-11-18/h6-15H,4-5,16-17H2,1-3H3,(H,24,25,26)/b15-12+
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n/an/a 1.76E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389554
PNG
(N'-{6-chloro-2-[(E)-2-(4- methoxyphenyl)vinyl]quin...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(Cl)ccc3n2)cc1
Show InChI InChI=1S/C22H25ClN4O/c1-27(2)14-4-13-24-22-19-15-17(23)8-11-20(19)25-21(26-22)12-7-16-5-9-18(28-3)10-6-16/h5-12,15H,4,13-14H2,1-3H3,(H,24,25,26)/b12-7+
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n/an/a 1.91E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389560
PNG
(N'-{6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]quina...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(OC)cc2)nc2ccc(Br)cc12
Show InChI InChI=1S/C24H29BrN4O/c1-4-29(5-2)16-6-15-26-24-21-17-19(25)10-13-22(21)27-23(28-24)14-9-18-7-11-20(30-3)12-8-18/h7-14,17H,4-6,15-16H2,1-3H3,(H,26,27,28)/b14-9+
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n/an/a 1.96E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389614
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylsulfonyl)phenyl]v...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccc(Cl)cc12
Show InChI InChI=1S/C24H29ClN4O2S/c1-4-29(5-2)16-6-15-26-24-21-17-19(25)10-13-22(21)27-23(28-24)14-9-18-7-11-20(12-8-18)32(3,30)31/h7-14,17H,4-6,15-16H2,1-3H3,(H,26,27,28)/b14-9+
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n/an/a 1.98E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389573
PNG
(N'-{6-bromo-2-[(E)-2-(3,4- difluorophenyl)vinyl]qu...)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(F)c(F)c2)nc2ccc(Br)cc12
Show InChI InChI=1S/C20H19BrF2N4/c1-27(2)10-9-24-20-15-12-14(21)5-7-18(15)25-19(26-20)8-4-13-3-6-16(22)17(23)11-13/h3-8,11-12H,9-10H2,1-2H3,(H,24,25,26)/b8-4+
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n/an/a 2.00E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389589
PNG
(N'-{2-[(E)-2-(4- isopropylphenyl)vinyl]quinazolin-...)
Show SMILES CC(C)c1ccc(\C=C\c2nc(NCCCN(C)C)c3ccccc3n2)cc1
Show InChI InChI=1S/C24H30N4/c1-18(2)20-13-10-19(11-14-20)12-15-23-26-22-9-6-5-8-21(22)24(27-23)25-16-7-17-28(3)4/h5-6,8-15,18H,7,16-17H2,1-4H3,(H,25,26,27)/b15-12+
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n/an/a 2.02E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389575
PNG
(N,N-diethyl-N'-{2-[(E)-2-(4- fluorophenyl)vinyl]qu...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(F)cc2)nc2ccccc12
Show InChI InChI=1S/C22H25FN4/c1-3-27(4-2)16-15-24-22-19-7-5-6-8-20(19)25-21(26-22)14-11-17-9-12-18(23)13-10-17/h5-14H,3-4,15-16H2,1-2H3,(H,24,25,26)/b14-11+
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n/an/a 2.12E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389567
PNG
(N'-{6-chloro-2-[(E)-2-(4- fluorophenyl)vinyl]quina...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C23H26ClFN4/c1-3-29(4-2)15-5-14-26-23-20-16-18(24)9-12-21(20)27-22(28-23)13-8-17-6-10-19(25)11-7-17/h6-13,16H,3-5,14-15H2,1-2H3,(H,26,27,28)/b13-8+
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n/an/a 2.26E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389565
PNG
(N'-{6-bromo-2-[(E)-2-(4- fluorophenyl)vinyl]quinaz...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(Br)cc12
Show InChI InChI=1S/C23H26BrFN4/c1-3-29(4-2)15-5-14-26-23-20-16-18(24)9-12-21(20)27-22(28-23)13-8-17-6-10-19(25)11-7-17/h6-13,16H,3-5,14-15H2,1-2H3,(H,26,27,28)/b13-8+
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n/an/a 2.28E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389595
PNG
(N'-{6-chloro-2-[(E)-2-(2- thienyl)vinyl]quinazolin...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2cccs2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C20H23ClN4S/c1-3-25(4-2)12-11-22-20-17-14-15(21)7-9-18(17)23-19(24-20)10-8-16-6-5-13-26-16/h5-10,13-14H,3-4,11-12H2,1-2H3,(H,22,23,24)/b10-8+
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n/an/a 2.31E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389584
PNG
(N,N-diethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]benzo[g...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2cccs2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C25H28N4S/c1-3-29(4-2)15-8-14-26-25-22-17-19-9-5-6-10-20(19)18-23(22)27-24(28-25)13-12-21-11-7-16-30-21/h5-7,9-13,16-18H,3-4,8,14-15H2,1-2H3,(H,26,27,28)/b13-12+
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n/an/a 2.33E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389599
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylthio)phenyl]vinyl...)
Show SMILES CSc1ccc(\C=C\c2nc(NCCCN(C)C)c3cc(Cl)ccc3n2)cc1
Show InChI InChI=1S/C22H25ClN4S/c1-27(2)14-4-13-24-22-19-15-17(23)8-11-20(19)25-21(26-22)12-7-16-5-9-18(28-3)10-6-16/h5-12,15H,4,13-14H2,1-3H3,(H,24,25,26)/b12-7+
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n/an/a 2.39E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389566
PNG
(N'-{6-chloro-2-[(E)-2-(4- fluorophenyl)vinyl]quina...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H22ClFN4/c1-27(2)13-3-12-24-21-18-14-16(22)7-10-19(18)25-20(26-21)11-6-15-4-8-17(23)9-5-15/h4-11,14H,3,12-13H2,1-2H3,(H,24,25,26)/b11-6+
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n/an/a 2.39E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389594
PNG
(N'-{6-chloro-2-[(E)-2-(2- thienyl)vinyl]quinazolin...)
Show SMILES CN(C)CCNc1nc(\C=C\c2cccs2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C18H19ClN4S/c1-23(2)10-9-20-18-15-12-13(19)5-7-16(15)21-17(22-18)8-6-14-4-3-11-24-14/h3-8,11-12H,9-10H2,1-2H3,(H,20,21,22)/b8-6+
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n/an/a 2.93E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389607
PNG
(N'-{6-chloro-2-[(E)-2-(4- isopropylphenyl)vinyl]qu...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(cc2)C(C)C)nc2ccc(Cl)cc12
Show InChI InChI=1S/C26H33ClN4/c1-5-31(6-2)17-7-16-28-26-23-18-22(27)13-14-24(23)29-25(30-26)15-10-20-8-11-21(12-9-20)19(3)4/h8-15,18-19H,5-7,16-17H2,1-4H3,(H,28,29,30)/b15-10+
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n/an/a 2.97E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389563
PNG
(N'-{2-[(E)-2-(4- fluorophenyl)vinyl]quinazolin-4-y...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccccc12
Show InChI InChI=1S/C21H23FN4/c1-26(2)15-5-14-23-21-18-6-3-4-7-19(18)24-20(25-21)13-10-16-8-11-17(22)12-9-16/h3-4,6-13H,5,14-15H2,1-2H3,(H,23,24,25)/b13-10+
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n/an/a 3.08E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389588
PNG
(N'-{2-[(E)-2-(3,4- difluorophenyl)vinyl]quinazolin...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(F)c(F)c2)nc2ccccc12
Show InChI InChI=1S/C22H24F2N4/c1-3-28(4-2)14-13-25-22-17-7-5-6-8-20(17)26-21(27-22)12-10-16-9-11-18(23)19(24)15-16/h5-12,15H,3-4,13-14H2,1-2H3,(H,25,26,27)/b12-10+
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n/an/a 3.25E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389577
PNG
(N-[3-({6-bromo-2-[(E)-2-(4- methoxyphenyl)vinyl]qu...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCNC(C)=O)c3cc(Br)ccc3n2)cc1
Show InChI InChI=1S/C22H23BrN4O2/c1-15(28)24-12-3-13-25-22-19-14-17(23)7-10-20(19)26-21(27-22)11-6-16-4-8-18(29-2)9-5-16/h4-11,14H,3,12-13H2,1-2H3,(H,24,28)(H,25,26,27)/b11-6+
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n/an/a 3.70E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389605
PNG
(2-{(E)-2-[4- (methylsulfonyl)phenyl]vinyl}-N- prop...)
Show SMILES CCCNc1nc(\C=C\c2ccc(cc2)S(C)(=O)=O)nc2ccccc12
Show InChI InChI=1S/C20H21N3O2S/c1-3-14-21-20-17-6-4-5-7-18(17)22-19(23-20)13-10-15-8-11-16(12-9-15)26(2,24)25/h4-13H,3,14H2,1-2H3,(H,21,22,23)/b13-10+
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n/an/a 3.82E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389568
PNG
(N'-{6-fluoro-2-[(E)-2-(4- fluorophenyl)vinyl]quina...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(F)cc12
Show InChI InChI=1S/C21H22F2N4/c1-27(2)13-3-12-24-21-18-14-17(23)9-10-19(18)25-20(26-21)11-6-15-4-7-16(22)8-5-15/h4-11,14H,3,12-13H2,1-2H3,(H,24,25,26)/b11-6+
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n/an/a 4.20E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389579
PNG
(N,N-dimethyl-N'-(2-{(E)-2-[4- (methylthio)phenyl]v...)
Show SMILES CSc1ccc(\C=C\c2nc(NCCCN(C)C)c3ccccc3n2)cc1
Show InChI InChI=1S/C22H26N4S/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25)/b14-11+
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n/an/a 4.50E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389569
PNG
(N,N-diethyl-N'-{6-fluoro-2-[(E)-2-(4- fluorophenyl...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccc(F)cc12
Show InChI InChI=1S/C23H26F2N4/c1-3-29(4-2)15-5-14-26-23-20-16-19(25)11-12-21(20)27-22(28-23)13-8-17-6-9-18(24)10-7-17/h6-13,16H,3-5,14-15H2,1-2H3,(H,26,27,28)/b13-8+
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n/an/a 4.76E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389561
PNG
(N'-{2-[(E)-2-(4- methoxyphenyl)vinyl]quinazolin-4-...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN(C)C)c3ccccc3n2)cc1
Show InChI InChI=1S/C22H26N4O/c1-26(2)16-6-15-23-22-19-7-4-5-8-20(19)24-21(25-22)14-11-17-9-12-18(27-3)13-10-17/h4-5,7-14H,6,15-16H2,1-3H3,(H,23,24,25)/b14-11+
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n/an/a 5.11E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389600
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylthio)phenyl]vinyl...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(SC)cc2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C24H29ClN4S/c1-4-29(5-2)16-6-15-26-24-21-17-19(25)10-13-22(21)27-23(28-24)14-9-18-7-11-20(30-3)12-8-18/h7-14,17H,4-6,15-16H2,1-3H3,(H,26,27,28)/b14-9+
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n/an/a 5.62E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389598
PNG
(N,N-dimethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]quinaz...)
Show SMILES CN(C)CCNc1nc(\C=C\c2cccs2)nc2ccccc12
Show InChI InChI=1S/C18H20N4S/c1-22(2)12-11-19-18-15-7-3-4-8-16(15)20-17(21-18)10-9-14-6-5-13-23-14/h3-10,13H,11-12H2,1-2H3,(H,19,20,21)/b10-9+
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n/an/a 6.29E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389580
PNG
(N'-{6-chloro-2-[(E)-2-(3,4- difluorophenyl)vinyl]q...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)c(F)c2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H21ClF2N4/c1-28(2)11-3-10-25-21-16-13-15(22)6-8-19(16)26-20(27-21)9-5-14-4-7-17(23)18(24)12-14/h4-9,12-13H,3,10-11H2,1-2H3,(H,25,26,27)/b9-5+
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n/an/a 6.32E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389592
PNG
(N'-{6-chloro-2-[(E)-2-(2- thienyl)quinazolin-4-yl]...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2cccs2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C19H21ClN4S/c1-24(2)11-4-10-21-19-16-13-14(20)6-8-17(16)22-18(23-19)9-7-15-5-3-12-25-15/h3,5-9,12-13H,4,10-11H2,1-2H3,(H,21,22,23)/b9-7+
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n/an/a 6.69E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389601
PNG
(N'-(6-chloro-2-{(E)-2-[4- (methylthio)phenyl]vinyl...)
Show SMILES CCN(CC)CCNc1nc(\C=C\c2ccc(SC)cc2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C23H27ClN4S/c1-4-28(5-2)15-14-25-23-20-16-18(24)9-12-21(20)26-22(27-23)13-8-17-6-10-19(29-3)11-7-17/h6-13,16H,4-5,14-15H2,1-3H3,(H,25,26,27)/b13-8+
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n/an/a 6.95E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389556
PNG
(N'-{6-chloro-2-[(E)-2-(4- methoxyphenyl)vinyl]quin...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(OC)cc2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C24H29ClN4O/c1-4-29(5-2)16-6-15-26-24-21-17-19(25)10-13-22(21)27-23(28-24)14-9-18-7-11-20(30-3)12-8-18/h7-14,17H,4-6,15-16H2,1-3H3,(H,26,27,28)/b14-9+
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n/an/a 7.67E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389596
PNG
(N,N-dimethyl-N'-{2-[(E)-2-(2- thienyl)vinyl]quinaz...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2cccs2)nc2ccccc12
Show InChI InChI=1S/C19H22N4S/c1-23(2)13-6-12-20-19-16-8-3-4-9-17(16)21-18(22-19)11-10-15-7-5-14-24-15/h3-5,7-11,14H,6,12-13H2,1-2H3,(H,20,21,22)/b11-10+
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n/an/a 7.78E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389570
PNG
(N,N-diethyl-N'-{2-[(E)-2-(4- methoxyphenyl)vinyl]b...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(OC)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C28H32N4O/c1-4-32(5-2)18-8-17-29-28-25-19-22-9-6-7-10-23(22)20-26(25)30-27(31-28)16-13-21-11-14-24(33-3)15-12-21/h6-7,9-16,19-20H,4-5,8,17-18H2,1-3H3,(H,29,30,31)/b16-13+
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n/an/a 8.53E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389564
PNG
(N,N-diethyl-N'-{2-[(E)-2-(4- fluorophenyl)vinyl]qu...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2ccccc12
Show InChI InChI=1S/C23H27FN4/c1-3-28(4-2)17-7-16-25-23-20-8-5-6-9-21(20)26-22(27-23)15-12-18-10-13-19(24)14-11-18/h5-6,8-15H,3-4,7,16-17H2,1-2H3,(H,25,26,27)/b15-12+
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n/an/a 8.61E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389587
PNG
(N'-{2-[(E)-2-(3,4- difluorophenyl)vinyl]quinazolin...)
Show SMILES CN(C)CCNc1nc(\C=C\c2ccc(F)c(F)c2)nc2ccccc12
Show InChI InChI=1S/C20H20F2N4/c1-26(2)12-11-23-20-15-5-3-4-6-18(15)24-19(25-20)10-8-14-7-9-16(21)17(22)13-14/h3-10,13H,11-12H2,1-2H3,(H,23,24,25)/b10-8+
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n/an/a 9.08E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389572
PNG
(N'-{6-bromo-2-[(E)-2-(3,4- difluorophenyl)vinyl]qu...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)c(F)c2)nc2ccc(Br)cc12
Show InChI InChI=1S/C21H21BrF2N4/c1-28(2)11-3-10-25-21-16-13-15(22)6-8-19(16)26-20(27-21)9-5-14-4-7-17(23)18(24)12-14/h4-9,12-13H,3,10-11H2,1-2H3,(H,25,26,27)/b9-5+
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n/an/a 9.68E+3n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389571
PNG
(N'-{2-[(E)-2-(4- fluorophenyl)vinyl]benzo[g]quinaz...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2ccc(F)cc2)nc2cc3ccccc3cc12
Show InChI InChI=1S/C25H25FN4/c1-30(2)15-5-14-27-25-22-16-19-6-3-4-7-20(19)17-23(22)28-24(29-25)13-10-18-8-11-21(26)12-9-18/h3-4,6-13,16-17H,5,14-15H2,1-2H3,(H,27,28,29)/b13-10+
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n/an/a 1.00E+4n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389555
PNG
(6-chloro-2-[(E)-2-(4- methoxyphenyl)vinyl]-N-(3- m...)
Show SMILES COc1ccc(\C=C\c2nc(NCCCN3CCOCC3)c3cc(Cl)ccc3n2)cc1
Show InChI InChI=1S/C24H27ClN4O2/c1-30-20-7-3-18(4-8-20)5-10-23-27-22-9-6-19(25)17-21(22)24(28-23)26-11-2-12-29-13-15-31-16-14-29/h3-10,17H,2,11-16H2,1H3,(H,26,27,28)/b10-5+
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n/an/a 1.00E+4n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389597
PNG
(N'-{6-bromo-2-[(E)-2-(2- thienyl)vinyl]quinazolin-...)
Show SMILES CN(C)CCCNc1nc(\C=C\c2cccs2)nc2ccc(Br)cc12
Show InChI InChI=1S/C19H21BrN4S/c1-24(2)11-4-10-21-19-16-13-14(20)6-8-17(16)22-18(23-19)9-7-15-5-3-12-25-15/h3,5-9,12-13H,4,10-11H2,1-2H3,(H,21,22,23)/b9-7+
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n/an/a 1.00E+4n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389593
PNG
(N'-{6-chloro-2-[(E)-2-(2- thienyl)vinyl]quinazolin...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2cccs2)nc2ccc(Cl)cc12
Show InChI InChI=1S/C21H25ClN4S/c1-3-26(4-2)13-6-12-23-21-18-15-16(22)8-10-19(18)24-20(25-21)11-9-17-7-5-14-27-17/h5,7-11,14-15H,3-4,6,12-13H2,1-2H3,(H,23,24,25)/b11-9+
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n/an/a 1.07E+4n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor FLT3


(Homo sapiens (Human))
BDBM389557
PNG
(N,N-diethyl-N'-{6-fluoro-2-[(E)-2-(4- methoxypheny...)
Show SMILES CCN(CC)CCCNc1nc(\C=C\c2ccc(OC)cc2)nc2ccc(F)cc12
Show InChI InChI=1S/C24H29FN4O/c1-4-29(5-2)16-6-15-26-24-21-17-19(25)10-13-22(21)27-23(28-24)14-9-18-7-11-20(30-3)12-8-18/h7-14,17H,4-6,15-16H2,1-3H3,(H,26,27,28)/b14-9+
PDB
MMDB

KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1.38E+4n/an/an/an/an/an/a



Vichem Chemie Kutató Kft.

US Patent


Assay Description
FLT3(ITD) biochemical assays were performed on two different assay system platforms, using TranscreenerŽ ADP Assay FP method (BellBrook Labs, Madison...


US Patent US9951029 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%