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Patent code US9951047

Compile Data Set for Download or QSAR
Found 4 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Fibroblast growth factor receptor 2


(Homo sapiens (human))
BDBM142256
PNG
(US8933099, 22 | US9951047, Compound (I))
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)
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n/an/a 5.10n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
To a flat bottom 96 well white plate (Sumitomo Bakelite Co., Ltd., MS-8496W), 10 μl of FGFR1 protein (Carna Biosciences, Inc., 08-133) solution ...


US Patent US9951047 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 1


(Homo sapiens (human))
BDBM142256
PNG
(US8933099, 22 | US9951047, Compound (I))
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)
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n/an/a 5.70n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
To a flat bottom 96 well white plate (Sumitomo Bakelite Co., Ltd., MS-8496W), 10 μl of FGFR1 protein (Carna Biosciences, Inc., 08-133) solution ...


US Patent US9951047 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 3


(Homo sapiens (Human))
BDBM142256
PNG
(US8933099, 22 | US9951047, Compound (I))
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)
PDB
MMDB

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PC sid
UniChem

Similars

n/an/a 6n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
To a flat bottom 96 well white plate (Sumitomo Bakelite Co., Ltd., MS-8496W), 10 μl of FGFR1 protein (Carna Biosciences, Inc., 08-133) solution ...


US Patent US9951047 (2018)

More data for this
Ligand-Target Pair
Fibroblast growth factor receptor 4


(Homo sapiens (Human))
BDBM142256
PNG
(US8933099, 22 | US9951047, Compound (I))
Show SMILES CNC(=O)n1ccc2cc(Oc3ccnc(NC(=O)c4ccc(cc4)C4CCN(CCO)CC4)c3)c(OCCOC)cc12
Show InChI InChI=1S/C32H37N5O6/c1-33-32(40)37-14-10-25-19-29(28(21-27(25)37)42-18-17-41-2)43-26-7-11-34-30(20-26)35-31(39)24-5-3-22(4-6-24)23-8-12-36(13-9-23)15-16-38/h3-7,10-11,14,19-21,23,38H,8-9,12-13,15-18H2,1-2H3,(H,33,40)(H,34,35,39)
PDB

KEGG

UniProtKB/SwissProt

DrugBank
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem

Similars

n/an/a 683n/an/an/an/an/an/a



Eisai R&D Management Co., Ltd.

US Patent


Assay Description
To a flat bottom 96 well white plate (Sumitomo Bakelite Co., Ltd., MS-8496W), 10 μl of FGFR1 protein (Carna Biosciences, Inc., 08-133) solution ...


US Patent US9951047 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%