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Patent code US9951048

Compile Data Set for Download or QSAR

Found 488 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293422
PNG
(US10106527, Compound 8 | US9951048, Compound 8)
Show SMILES CN1CCC(CC1)Oc1ccc(cc1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C26H27N5O2/c1-30-11-9-24(10-12-30)33-23-7-5-18(6-8-23)26(32)29-25-14-21-13-19(3-4-20(21)15-27-25)22-16-28-31(2)17-22/h3-8,13-17,24H,9-12H2,1-2H3,(H,27,29,32)
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n/an/an/an/a 668n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293423
PNG
(US10106527, Compound 461 | US10106527, Compound 9 ...)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCNCC3)cc2c1
Show InChI InChI=1S/C23H23N7O/c1-29-15-20(14-27-29)16-2-3-18-13-26-21(11-19(18)10-16)28-23(31)17-4-5-25-22(12-17)30-8-6-24-7-9-30/h2-5,10-15,24H,6-9H2,1H3,(H,26,28,31)
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n/an/an/an/a 3.40E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293425
PNG
(US10106527, Compound 11 | US9951048, Compound 11)
Show SMILES CC(C)N1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C26H29N7O/c1-18(2)32-8-10-33(11-9-32)25-14-20(6-7-27-25)26(34)30-24-13-22-12-19(4-5-21(22)15-28-24)23-16-29-31(3)17-23/h4-7,12-18H,8-11H2,1-3H3,(H,28,30,34)
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n/an/an/an/a 3.90E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293428
PNG
(US10106527, Compound 14 | US9951048, Compound 14)
Show SMILES CN1CCN(CC1)c1ccc(cn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C24H25N7O/c1-29-7-9-31(10-8-29)23-6-5-19(14-26-23)24(32)28-22-12-20-11-17(3-4-18(20)13-25-22)21-15-27-30(2)16-21/h3-6,11-16H,7-10H2,1-2H3,(H,25,28,32)
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Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293430
PNG
(US10106527, Compound 16 | US9951048, Compound 16)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(OC4CCNCC4)c3)cc2c1
Show InChI InChI=1S/C24H24N6O2/c1-30-15-20(14-28-30)16-2-3-18-13-27-22(11-19(18)10-16)29-24(31)17-4-9-26-23(12-17)32-21-5-7-25-8-6-21/h2-4,9-15,21,25H,5-8H2,1H3,(H,27,29,31)
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n/an/an/an/a 1.26E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293438
PNG
(US10106527, Compound 24 | US9951048, Compound 24)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1ccc2cnc(NC(=O)c3ccc(F)cc3)cc2c1
Show InChI InChI=1S/C25H24FN5O/c1-30-10-8-23(9-11-30)31-16-21(15-28-31)18-2-3-19-14-27-24(13-20(19)12-18)29-25(32)17-4-6-22(26)7-5-17/h2-7,12-16,23H,8-11H2,1H3,(H,27,29,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293446
PNG
(US10106527, Compound 45 | US9951048, Compound 45)
Show SMILES Cc1ncc(-c2ccc3cnc(NC(=O)c4ccc(OC5CCNCC5)cc4)cc3c2)n1C
Show InChI InChI=1S/C26H27N5O2/c1-17-28-16-24(31(17)2)19-3-4-20-15-29-25(14-21(20)13-19)30-26(32)18-5-7-22(8-6-18)33-23-9-11-27-12-10-23/h3-8,13-16,23,27H,9-12H2,1-2H3,(H,29,30,32)
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n/an/an/an/a 1.88E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293448
PNG
(US10106527, Compound 49 | US9951048, Compound 49)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnc(C)n1C
Show InChI InChI=1S/C25H27N7O/c1-17-27-16-22(31(17)3)18-4-5-20-15-28-23(13-21(20)12-18)29-25(33)19-6-7-26-24(14-19)32-10-8-30(2)9-11-32/h4-7,12-16H,8-11H2,1-3H3,(H,28,29,33)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293449
PNG
(US10106527, Compound 52 | US9951048, Compound 52)
Show SMILES CC(C)Oc1ccc(cc1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnc2CNCCn12
Show InChI InChI=1S/C25H25N5O2/c1-16(2)32-21-7-5-17(6-8-21)25(31)29-23-12-20-11-18(3-4-19(20)13-27-23)22-14-28-24-15-26-9-10-30(22)24/h3-8,11-14,16,26H,9-10,15H2,1-2H3,(H,27,29,31)
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n/an/an/an/a 4.32E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293463
PNG
(US10106527, Compound 67 | US9951048, Compound 67)
Show SMILES CCN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C25H27N7O/c1-3-31-8-10-32(11-9-31)24-14-19(6-7-26-24)25(33)29-23-13-21-12-18(4-5-20(21)15-27-23)22-16-28-30(2)17-22/h4-7,12-17H,3,8-11H2,1-2H3,(H,27,29,33)
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n/an/an/an/a 3.65E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293472
PNG
(US10106527, Compound 86 | US9951048, Compound 86)
Show SMILES CN1CCN(CC1)c1ccc(cn1)C(=O)N1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C34H36N10O2/c1-40-9-11-42(12-10-40)31-6-5-27(21-37-31)34(46)44-15-13-43(14-16-44)32-19-25(7-8-35-32)33(45)39-30-18-28-17-24(3-4-26(28)20-36-30)29-22-38-41(2)23-29/h3-8,17-23H,9-16H2,1-2H3,(H,36,39,45)
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n/an/an/an/a 3.05E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293483
PNG
(US10106527, Compound 99 | US9951048, Compound 99)
Show SMILES CN1CCC(CC1)Sc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C25H26N6OS/c1-30-9-6-22(7-10-30)33-24-13-18(5-8-26-24)25(32)29-23-12-20-11-17(3-4-19(20)14-27-23)21-15-28-31(2)16-21/h3-5,8,11-16,22H,6-7,9-10H2,1-2H3,(H,27,29,32)
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n/an/an/an/a 1.57E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293490
PNG
(US10106527, Compound 106 | US9951048, Compound 106)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)CCc3cccnc3)cc2c1
Show InChI InChI=1S/C21H19N5O/c1-26-14-19(13-24-26)16-5-6-17-12-23-20(10-18(17)9-16)25-21(27)7-4-15-3-2-8-22-11-15/h2-3,5-6,8-14H,4,7H2,1H3,(H,23,25,27)
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n/an/an/an/a 2n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293491
PNG
(US10106527, Compound 107 | US9951048, Compound 107)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)Cc3ccncc3)cc2c1
Show InChI InChI=1S/C20H17N5O/c1-25-13-18(12-23-25)15-2-3-16-11-22-19(10-17(16)9-15)24-20(26)8-14-4-6-21-7-5-14/h2-7,9-13H,8H2,1H3,(H,22,24,26)
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n/an/an/an/a 10n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293494
PNG
(US10106527, Compound 110 | US9951048, Compound 110)
Show SMILES CN1Cc2ccc(cc2C1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C23H21N5O/c1-27-12-18-6-4-16(8-20(18)13-27)23(29)26-22-9-19-7-15(3-5-17(19)10-24-22)21-11-25-28(2)14-21/h3-11,14H,12-13H2,1-2H3,(H,24,26,29)
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n/an/an/an/a 1.80E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293497
PNG
(US10106527, Compound 113 | US9951048, Compound 113)
Show SMILES CN1CCc2cc(ccc2C1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C24H23N5O/c1-28-8-7-17-9-18(4-6-20(17)14-28)24(30)27-23-11-21-10-16(3-5-19(21)12-25-23)22-13-26-29(2)15-22/h3-6,9-13,15H,7-8,14H2,1-2H3,(H,25,27,30)
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n/an/an/an/a 1.71E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293504
PNG
(US10106527, Compound 122 | US9951048, Compound 122)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccc4ncoc4c3)cc2c1
Show InChI InChI=1S/C21H15N5O2/c1-26-11-17(10-24-26)13-2-3-15-9-22-20(8-16(15)6-13)25-21(27)14-4-5-18-19(7-14)28-12-23-18/h2-12H,1H3,(H,22,25,27)
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n/an/an/an/a 4.62E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293532
PNG
(US10106527, Compound 183 | US9951048, Compound 183)
Show SMILES Cn1ncc(c1CN1CCCCC1)-c1ccc2cnc(NC(=O)c3ccc(F)cc3)cc2c1
Show InChI InChI=1S/C26H26FN5O/c1-31-24(17-32-11-3-2-4-12-32)23(16-29-31)19-5-6-20-15-28-25(14-21(20)13-19)30-26(33)18-7-9-22(27)10-8-18/h5-10,13-16H,2-4,11-12,17H2,1H3,(H,28,30,33)
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n/an/an/an/a 704n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293547
PNG
(US10106527, Compound 240 | US9951048, Compound 240)
Show SMILES CN(C)C1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn(C)nn1
Show InChI InChI=1S/C25H28N8O/c1-31(2)21-7-10-33(11-8-21)24-14-18(6-9-26-24)25(34)28-23-13-20-12-17(4-5-19(20)15-27-23)22-16-32(3)30-29-22/h4-6,9,12-16,21H,7-8,10-11H2,1-3H3,(H,27,28,34)
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n/an/an/an/a 212n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293553
PNG
(US10106527, Compound 250 | US9951048, Compound 250)
Show SMILES CN(C1CCN(C)CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cn(C)nn1
Show InChI InChI=1S/C25H28N8O/c1-31-10-7-21(8-11-31)33(3)24-14-18(6-9-26-24)25(34)28-23-13-20-12-17(4-5-19(20)15-27-23)22-16-32(2)30-29-22/h4-6,9,12-16,21H,7-8,10-11H2,1-3H3,(H,27,28,34)
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n/an/an/an/a 568n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293557
PNG
(US10106527, Compound 258 | US9951048, Compound 258)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-n1cncn1
Show InChI InChI=1S/C22H22N8O/c1-28-6-8-29(9-7-28)21-12-16(4-5-24-21)22(31)27-20-11-18-10-19(30-15-23-14-26-30)3-2-17(18)13-25-20/h2-5,10-15H,6-9H2,1H3,(H,25,27,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293560
PNG
(US10106527, Compound 266 | US9951048, Compound 266)
Show SMILES Cn1cncc1-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CC(N)C3)cc2c1
Show InChI InChI=1S/C22H21N7O/c1-28-13-24-10-19(28)14-2-3-16-9-26-20(7-17(16)6-14)27-22(30)15-4-5-25-21(8-15)29-11-18(23)12-29/h2-10,13,18H,11-12,23H2,1H3,(H,26,27,30)
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n/an/an/an/a 2.50E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293570
PNG
(US10106527, Compound 289 | US9951048, Compound 289)
Show SMILES Cc1ncc(-c2ccc3cnc(NC(=O)c4ccnc(c4)N4CCOCC4)cc3c2)n1C
Show InChI InChI=1S/C24H24N6O2/c1-16-26-15-21(29(16)2)17-3-4-19-14-27-22(12-20(19)11-17)28-24(31)18-5-6-25-23(13-18)30-7-9-32-10-8-30/h3-6,11-15H,7-10H2,1-2H3,(H,27,28,31)
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n/an/an/an/a 6.00E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293579
PNG
(US10106527, Compound 309 | US9951048, Compound 309)
Show SMILES CN1CCC(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnco1
Show InChI InChI=1S/C24H23N5O2/c1-29-8-5-16(6-9-29)21-11-18(4-7-26-21)24(30)28-23-12-20-10-17(22-14-25-15-31-22)2-3-19(20)13-27-23/h2-4,7,10-16H,5-6,8-9H2,1H3,(H,27,28,30)
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n/an/an/an/a 2.69E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293590
PNG
(US10106527, Compound 331 | US9951048, Compound 331)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1ncc(C)s1
Show InChI InChI=1S/C24H24N6OS/c1-16-14-27-24(32-16)18-3-4-19-15-26-21(12-20(19)11-18)28-23(31)17-5-6-25-22(13-17)30-9-7-29(2)8-10-30/h3-6,11-15H,7-10H2,1-2H3,(H,26,28,31)
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n/an/an/an/a>1.00E+4n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293602
PNG
(US10106527, Compound 374 | US9951048, Compound 374)
Show SMILES CNc1ncc(s1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CC(C3)N(C)C)cc2c1
Show InChI InChI=1S/C24H25N7OS/c1-25-24-28-12-20(33-24)15-4-5-17-11-27-21(9-18(17)8-15)29-23(32)16-6-7-26-22(10-16)31-13-19(14-31)30(2)3/h4-12,19H,13-14H2,1-3H3,(H,25,28)(H,27,29,32)
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n/an/an/an/a 5.46E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293604
PNG
(US10106527, Compound 376 | US9951048, Compound 376)
Show SMILES CNc1ncc(s1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCN(C)CC3)cc2c1
Show InChI InChI=1S/C24H25N7OS/c1-25-24-28-15-20(33-24)16-3-4-18-14-27-21(12-19(18)11-16)29-23(32)17-5-6-26-22(13-17)31-9-7-30(2)8-10-31/h3-6,11-15H,7-10H2,1-2H3,(H,25,28)(H,27,29,32)
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Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293610
PNG
(US10106527, Compound 382 | US9951048, Compound 382)
Show SMILES FC(F)Oc1ccc(cc1)C(=O)Nc1cc2cc(ccc2cn1)-c1nncs1
Show InChI InChI=1S/C19H12F2N4O2S/c20-19(21)27-15-5-3-11(4-6-15)17(26)24-16-8-14-7-12(18-25-23-10-28-18)1-2-13(14)9-22-16/h1-10,19H,(H,22,24,26)
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n/an/an/an/a 367n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293630
PNG
(US10106527, Compound 428 | US9951048, Compound 428)
Show SMILES CN(C)c1nnc(s1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCN(C)CC3)cc2c1
Show InChI InChI=1S/C24H26N8OS/c1-30(2)24-29-28-23(34-24)17-4-5-18-15-26-20(13-19(18)12-17)27-22(33)16-6-7-25-21(14-16)32-10-8-31(3)9-11-32/h4-7,12-15H,8-11H2,1-3H3,(H,26,27,33)
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n/an/an/an/a 1.41E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293631
PNG
(US10106527, Compound 429 | US9951048, Compound 429)
Show SMILES Cn1ncc(c1CN1CCCCC1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCOCC3)cc2c1
Show InChI InChI=1S/C29H33N7O2/c1-34-26(20-35-9-3-2-4-10-35)25(19-32-34)21-5-6-23-18-31-27(16-24(23)15-21)33-29(37)22-7-8-30-28(17-22)36-11-13-38-14-12-36/h5-8,15-19H,2-4,9-14,20H2,1H3,(H,31,33,37)
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n/an/an/an/a 1.66E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293636
PNG
(US10106527, Compound 434 | US9951048, Compound 434)
Show SMILES Cc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cncn1C
Show InChI InChI=1S/C20H17N5O/c1-13-7-15(5-6-22-13)20(26)24-19-9-17-8-14(3-4-16(17)10-23-19)18-11-21-12-25(18)2/h3-12H,1-2H3,(H,23,24,26)
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n/an/an/an/a 1.86E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293640
PNG
(US10106527, Compound 438 | US9951048, Compound 438)
Show SMILES Cn1cc(nn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CC[N+](C)(C)CC3)cc2c1
Show InChI InChI=1S/C24H26N8O/c1-30-16-21(28-29-30)17-4-5-19-15-26-22(13-20(19)12-17)27-24(33)18-6-7-25-23(14-18)31-8-10-32(2,3)11-9-31/h4-7,12-16H,8-11H2,1-3H3/p+1
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n/an/an/an/a 1.65E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293642
PNG
(US10106527, Compound 440 | US9951048, Compound 440)
Show SMILES CN1CCN(CC1)c1nccc(C(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)c1Cl
Show InChI InChI=1S/C24H24ClN7O/c1-30-7-9-32(10-8-30)23-22(25)20(5-6-26-23)24(33)29-21-12-18-11-16(3-4-17(18)13-27-21)19-14-28-31(2)15-19/h3-6,11-15H,7-10H2,1-2H3,(H,27,29,33)
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n/an/an/an/a 4.54E+3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Glycogen synthase kinase-3 beta


(Homo sapiens (Human))
BDBM293655
PNG
(US10106527, Compound 462 | US9951048, Compound 463)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccc4n(C)ncc4c3)cc2c1
Show InChI InChI=1S/C22H18N6O/c1-27-13-19(12-24-27)14-3-4-16-10-23-21(9-17(16)7-14)26-22(29)15-5-6-20-18(8-15)11-25-28(20)2/h3-13H,1-2H3,(H,23,26,29)
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n/an/an/an/a 261n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The GSK3β kinase assay is run using the Ser/Thr 09 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologiesa Div...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293416
PNG
(US10106527, Compound 2 | US9951048, Compound 2)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3cccc(c3)N3CCNCC3)cc2c1
Show InChI InChI=1S/C24H24N6O/c1-29-16-21(15-27-29)17-5-6-19-14-26-23(13-20(19)11-17)28-24(31)18-3-2-4-22(12-18)30-9-7-25-8-10-30/h2-6,11-16,25H,7-10H2,1H3,(H,26,28,31)
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n/an/an/an/a 1.30n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293420
PNG
(US10106527, Compound 6 | US9951048, Compound 6)
Show SMILES CN1CCC(CC1)Oc1cccc(c1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C26H27N5O2/c1-30-10-8-23(9-11-30)33-24-5-3-4-19(13-24)26(32)29-25-14-21-12-18(6-7-20(21)15-27-25)22-16-28-31(2)17-22/h3-7,12-17,23H,8-11H2,1-2H3,(H,27,29,32)
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n/an/an/an/a 1.10n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293428
PNG
(US10106527, Compound 14 | US9951048, Compound 14)
Show SMILES CN1CCN(CC1)c1ccc(cn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C24H25N7O/c1-29-7-9-31(10-8-29)23-6-5-19(14-26-23)24(32)28-22-12-20-11-17(3-4-18(20)13-25-22)21-15-27-30(2)16-21/h3-6,11-16H,7-10H2,1-2H3,(H,25,28,32)
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n/an/an/an/a 0.900n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293434
PNG
(US10106527, Compound 20 | US9951048, Compound 20)
Show SMILES CC(C)n1cc(cn1)-c1ccc2cnc(NC(=O)c3cccc(OC4CCNCC4)c3)cc2c1
Show InChI InChI=1S/C27H29N5O2/c1-18(2)32-17-23(16-30-32)19-6-7-21-15-29-26(14-22(21)12-19)31-27(33)20-4-3-5-25(13-20)34-24-8-10-28-11-9-24/h3-7,12-18,24,28H,8-11H2,1-2H3,(H,29,31,33)
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n/an/an/an/a 55.2n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293438
PNG
(US10106527, Compound 24 | US9951048, Compound 24)
Show SMILES CN1CCC(CC1)n1cc(cn1)-c1ccc2cnc(NC(=O)c3ccc(F)cc3)cc2c1
Show InChI InChI=1S/C25H24FN5O/c1-30-10-8-23(9-11-30)31-16-21(15-28-31)18-2-3-19-14-27-24(13-20(19)12-18)29-25(32)17-4-6-22(26)7-5-17/h2-7,12-16,23H,8-11H2,1H3,(H,27,29,32)
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n/an/an/an/a 67.3n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293448
PNG
(US10106527, Compound 49 | US9951048, Compound 49)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnc(C)n1C
Show InChI InChI=1S/C25H27N7O/c1-17-27-16-22(31(17)3)18-4-5-20-15-28-23(13-21(20)12-18)29-25(33)19-6-7-26-24(14-19)32-10-8-30(2)9-11-32/h4-7,12-16H,8-11H2,1-3H3,(H,28,29,33)
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n/an/an/an/a 4.20n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293450
PNG
(US10106527, Compound 53 | US9951048, Compound 53)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(c3)N3CCC(N)CC3)cc2c1
Show InChI InChI=1S/C24H25N7O/c1-30-15-20(14-28-30)16-2-3-18-13-27-22(11-19(18)10-16)29-24(32)17-4-7-26-23(12-17)31-8-5-21(25)6-9-31/h2-4,7,10-15,21H,5-6,8-9,25H2,1H3,(H,27,29,32)
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Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293458
PNG
(US10106527, Compound 62 | US9951048, Compound 62)
Show SMILES CN(C)CCNc1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C23H25N7O/c1-29(2)9-8-25-21-11-17(6-7-24-21)23(31)28-22-12-19-10-16(4-5-18(19)13-26-22)20-14-27-30(3)15-20/h4-7,10-15H,8-9H2,1-3H3,(H,24,25)(H,26,28,31)
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n/an/an/an/a 2.30n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293460
PNG
(US10106527, Compound 64 | US9951048, Compound 64)
Show SMILES CC(C)CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Show InChI InChI=1S/C27H31N7O/c1-19(2)17-33-8-10-34(11-9-33)26-14-21(6-7-28-26)27(35)31-25-13-23-12-20(4-5-22(23)15-29-25)24-16-30-32(3)18-24/h4-7,12-16,18-19H,8-11,17H2,1-3H3,(H,29,31,35)
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n/an/an/an/a 3.30n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293467
PNG
(US10106527, Compound 76 | US9951048, Compound 76)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccncc3)cc2c1
Show InChI InChI=1S/C19H15N5O/c1-24-12-17(11-22-24)14-2-3-15-10-21-18(9-16(15)8-14)23-19(25)13-4-6-20-7-5-13/h2-12H,1H3,(H,21,23,25)
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n/an/an/an/a 2.80n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293468
PNG
(US10106527, Compound 78 | US9951048, Compound 78)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)c3ccnc(O)c3)cc2c1
Show InChI InChI=1S/C19H15N5O2/c1-24-11-16(10-22-24)12-2-3-14-9-21-17(7-15(14)6-12)23-19(26)13-4-5-20-18(25)8-13/h2-11H,1H3,(H,20,25)(H,21,23,26)
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n/an/an/an/a 2.10n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293479
PNG
(US10106527, Compound 93 | US9951048, Compound 93)
Show SMILES CN1CCC2(CN(C2)c2cc(ccn2)C(=O)Nc2cc3cc(ccc3cn2)-c2cnn(C)c2)CC1
Show InChI InChI=1S/C27H29N7O/c1-32-9-6-27(7-10-32)17-34(18-27)25-13-20(5-8-28-25)26(35)31-24-12-22-11-19(3-4-21(22)14-29-24)23-15-30-33(2)16-23/h3-5,8,11-16H,6-7,9-10,17-18H2,1-2H3,(H,29,31,35)
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n/an/an/an/a 0.700n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293490
PNG
(US10106527, Compound 106 | US9951048, Compound 106)
Show SMILES Cn1cc(cn1)-c1ccc2cnc(NC(=O)CCc3cccnc3)cc2c1
Show InChI InChI=1S/C21H19N5O/c1-26-14-19(13-24-26)16-5-6-17-12-23-20(10-18(17)9-16)25-21(27)7-4-15-3-2-8-22-11-15/h2-3,5-6,8-14H,4,7H2,1H3,(H,23,25,27)
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n/an/an/an/a 3.40n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293529
PNG
(US10106527, Compound 168 | US9951048, Compound 168)
Show SMILES CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1CO
Show InChI InChI=1S/C25H27N7O2/c1-30-7-9-32(10-8-30)24-13-18(5-6-26-24)25(34)29-23-12-20-11-17(3-4-19(20)14-27-23)21-15-28-31(2)22(21)16-33/h3-6,11-15,33H,7-10,16H2,1-2H3,(H,27,29,34)
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n/an/an/an/a 3.40n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293539
PNG
(US10106527, Compound 221 | US9951048, Compound 221)
Show SMILES CNC(=O)c1ccc(cn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn2CCN(CCF)Cc12
Show InChI InChI=1S/C25H24FN7O2/c1-27-25(35)21-5-4-18(13-28-21)24(34)31-23-11-19-10-16(2-3-17(19)12-29-23)20-14-30-33-9-8-32(7-6-26)15-22(20)33/h2-5,10-14H,6-9,15H2,1H3,(H,27,35)(H,29,31,34)
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n/an/an/an/a 2.60n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
Dual-specificity tyrosine-phosphorylation regulated kinase 1A


(Homo sapiens (Human))
BDBM293552
PNG
(US10106527, Compound 249 | US9951048, Compound 249)
Show SMILES Cn1cc(nn1)-c1ccc2cnc(NC(=O)c3ccnc(NC4CCNCC4)c3)cc2c1
Show InChI InChI=1S/C23H24N8O/c1-31-14-20(29-30-31)15-2-3-17-13-26-22(12-18(17)10-15)28-23(32)16-4-9-25-21(11-16)27-19-5-7-24-8-6-19/h2-4,9-14,19,24H,5-8H2,1H3,(H,25,27)(H,26,28,32)
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n/an/an/an/a 1.80n/an/an/an/a



Samumed, LLC

US Patent


Assay Description
The DYRKIA kinase assay was run using the Ser/Thr 18 peptide Z-lyte assay kit according to manufacturer's instructions (Life Technologies-a Divis...


US Patent US9951048 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%