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Patent code US9951056

Compile Data Set for Download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389631
PNG
(6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)ni...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C26H25N3O3/c1-2-24(30)29-16-14-18(15-17-29)23-13-12-22(26(27)31)25(28-23)19-8-10-21(11-9-19)32-20-6-4-3-5-7-20/h2-13,18H,1,14-17H2,(H2,27,31)
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n/an/a<500n/an/an/an/an/an/a



BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389675
PNG
(5-(1-acryloylpiperidin-4-yl)-4′-phenoxybiphe...)
Show SMILES NC(=O)c1ccc(cc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C27H26N2O3/c1-2-26(30)29-16-14-19(15-17-29)21-10-13-24(27(28)31)25(18-21)20-8-11-23(12-9-20)32-22-6-4-3-5-7-22/h2-13,18-19H,1,14-17H2,(H2,28,31)
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n/an/a<500n/an/an/an/an/an/a



BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389633
PNG
(6-(1-acryloylpyrrolidin-3-yl)-2-(4-phenoxyphenyl)n...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H23N3O3/c1-2-23(29)28-15-14-18(16-28)22-13-12-21(25(26)30)24(27-22)17-8-10-20(11-9-17)31-19-6-4-3-5-7-19/h2-13,18H,1,14-16H2,(H2,26,30)
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n/an/a<500n/an/an/an/an/an/a



BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389651
PNG
((E)-6-(4-(4-(dimethylamino)but-2-enoyl)piperazin-1...)
Show SMILES CN(C)C\C=C\C(=O)N1CCN(CC1)c1ccc(C(N)=O)c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C28H31N5O3/c1-31(2)16-6-9-26(34)33-19-17-32(18-20-33)25-15-14-24(28(29)35)27(30-25)21-10-12-23(13-11-21)36-22-7-4-3-5-8-22/h3-15H,16-20H2,1-2H3,(H2,29,35)/b9-6+
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389664
PNG
(2-(1-acryloylpiperidin-3-yl)-4-(4-phenoxyphenyl)ox...)
Show SMILES NC(=O)c1oc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23N3O4/c1-2-20(28)27-14-6-7-17(15-27)24-26-21(22(31-24)23(25)29)16-10-12-19(13-11-16)30-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15H2,(H2,25,29)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389671
PNG
(2-(1-acryloylpiperidin-4-yl)-5-(4-phenoxyphenyl)th...)
Show SMILES NC(=O)c1nc(sc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H23N3O3S/c1-2-20(28)27-14-12-17(13-15-27)24-26-21(23(25)29)22(31-24)16-8-10-19(11-9-16)30-18-6-4-3-5-7-18/h2-11,17H,1,12-15H2,(H2,25,29)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389673
PNG
(2-(1-acryloylpiperidin-4-yl)-4-(4-phenoxyphenyl)th...)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H23N3O3S/c1-2-20(28)27-14-12-17(13-15-27)24-26-21(22(31-24)23(25)29)16-8-10-19(11-9-16)30-18-6-4-3-5-7-18/h2-11,17H,1,12-15H2,(H2,25,29)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389676
PNG
(5-(4-acryloylpiperazin-1-yl)-4′-phenoxybiphe...)
Show SMILES NC(=O)c1ccc(cc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C26H25N3O3/c1-2-25(30)29-16-14-28(15-17-29)20-10-13-23(26(27)31)24(18-20)19-8-11-22(12-9-19)32-21-6-4-3-5-7-21/h2-13,18H,1,14-17H2,(H2,27,31)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389678
PNG
(6-(1-acryloylpiperidin-4-yl)-2-(4-(hydroxy(phenyl)...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(cc1)C(O)c1ccccc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C27H27N3O3/c1-2-24(31)30-16-14-18(15-17-30)23-13-12-22(27(28)33)25(29-23)19-8-10-21(11-9-19)26(32)20-6-4-3-5-7-20/h2-13,18,26,32H,1,14-17H2,(H2,28,33)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389645
PNG
(1-(3-acrylamidophenyl)-3-(4-phenoxyphenyl)-1H-pyra...)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C25H20N4O3/c1-2-23(30)27-18-7-6-8-19(15-18)29-16-22(25(26)31)24(28-29)17-11-13-21(14-12-17)32-20-9-4-3-5-10-20/h2-16H,1H2,(H2,26,31)(H,27,30)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389662
PNG
(2-(1-acryloylpiperidin-3-yl)-4-(4-phenoxyphenyl)th...)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23N3O3S/c1-2-20(28)27-14-6-7-17(15-27)24-26-21(22(31-24)23(25)29)16-10-12-19(13-11-16)30-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15H2,(H2,25,29)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389657
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(4-(3-fluorophenoxy...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2cccc(F)c2)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H23FN4O3/c1-2-23(31)30-14-12-29(13-15-30)22-11-10-21(25(27)32)24(28-22)17-6-8-19(9-7-17)33-20-5-3-4-18(26)16-20/h2-11,16H,1,12-15H2,(H2,27,32)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389646
PNG
((S)-1-(1-acryloylpyrrolidin-3-yl)-3-(4-phenoxyphen...)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)[C@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H22N4O3/c1-2-21(28)26-13-12-17(14-26)27-15-20(23(24)29)22(25-27)16-8-10-19(11-9-16)30-18-6-4-3-5-7-18/h2-11,15,17H,1,12-14H2,(H2,24,29)/t17-/m0/s1
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389637
PNG
(1-(1-acryloylpiperidin-3-yl)-3-(4-phenoxyphenyl)-1...)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H24N4O3/c1-2-22(29)27-14-6-7-18(15-27)28-16-21(24(25)30)23(26-28)17-10-12-20(13-11-17)31-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,25,30)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389634
PNG
(6-(4-acrylamidophenyl)-2-(4-phenoxyphenyl)nicotina...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)-c1ccc(NC(=O)C=C)cc1
Show InChI InChI=1S/C27H21N3O3/c1-2-25(31)29-20-12-8-18(9-13-20)24-17-16-23(27(28)32)26(30-24)19-10-14-22(15-11-19)33-21-6-4-3-5-7-21/h2-17H,1H2,(H2,28,32)(H,29,31)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389630
PNG
(6-(3-acrylamidophenyl)-2-(4-phenoxyphenyl)nicotina...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C27H21N3O3/c1-2-25(31)29-20-8-6-7-19(17-20)24-16-15-23(27(28)32)26(30-24)18-11-13-22(14-12-18)33-21-9-4-3-5-10-21/h2-17H,1H2,(H2,28,32)(H,29,31)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389672
PNG
(2-(4-acryloylpiperazin-1-yl)-4-(4-phenoxyphenyl)th...)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C23H22N4O3S/c1-2-19(28)26-12-14-27(15-13-26)23-25-20(21(31-23)22(24)29)16-8-10-18(11-9-16)30-17-6-4-3-5-7-17/h2-11H,1,12-15H2,(H2,24,29)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389670
PNG
(2-(1-acryloylpyrrolidin-3-yl)-5-(4-phenoxyphenyl)o...)
Show SMILES NC(=O)c1nc(oc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H21N3O4/c1-2-19(27)26-13-12-16(14-26)23-25-20(22(24)28)21(30-23)15-8-10-18(11-9-15)29-17-6-4-3-5-7-17/h2-11,16H,1,12-14H2,(H2,24,28)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389665
PNG
(2-(1-acryloylpyrrolidin-3-yl)-4-(4-phenoxyphenyl)o...)
Show SMILES NC(=O)c1oc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H21N3O4/c1-2-19(27)26-13-12-16(14-26)23-25-20(21(30-23)22(24)28)15-8-10-18(11-9-15)29-17-6-4-3-5-7-17/h2-11,16H,1,12-14H2,(H2,24,28)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389659
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(4-(4-fluorophenoxy...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccc(F)cc2)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H23FN4O3/c1-2-23(31)30-15-13-29(14-16-30)22-12-11-21(25(27)32)24(28-22)17-3-7-19(8-4-17)33-20-9-5-18(26)6-10-20/h2-12H,1,13-16H2,(H2,27,32)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389655
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(4-(pyridin-2-yloxy...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccn2)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H23N5O3/c1-2-22(30)29-15-13-28(14-16-29)20-11-10-19(24(25)31)23(27-20)17-6-8-18(9-7-17)32-21-5-3-4-12-26-21/h2-12H,1,13-16H2,(H2,25,31)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389642
PNG
(1-(1-acryloylazetidin-3-yl)-3-(4-phenoxyphenyl)-1H...)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C22H20N4O3/c1-2-20(27)25-12-16(13-25)26-14-19(22(23)28)21(24-26)15-8-10-18(11-9-15)29-17-6-4-3-5-7-17/h2-11,14,16H,1,12-13H2,(H2,23,28)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389647
PNG
((R)-1-(1-acryloylpyrrolidin-3-yl)-3-(4-phenoxyphen...)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H22N4O3/c1-2-21(28)26-13-12-17(14-26)27-15-20(23(24)29)22(25-27)16-8-10-19(11-9-16)30-18-6-4-3-5-7-18/h2-11,15,17H,1,12-14H2,(H2,24,29)/t17-/m1/s1
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389652
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(4-phenoxyphenyl)py...)
Show SMILES OC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H23N3O4/c1-2-23(29)28-16-14-27(15-17-28)22-13-12-21(25(30)31)24(26-22)18-8-10-20(11-9-18)32-19-6-4-3-5-7-19/h2-13H,1,14-17H2,(H,30,31)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389653
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(4-(cyclohexyloxy)p...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(OC2CCCCC2)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H30N4O3/c1-2-23(30)29-16-14-28(15-17-29)22-13-12-21(25(26)31)24(27-22)18-8-10-20(11-9-18)32-19-6-4-3-5-7-19/h2,8-13,19H,1,3-7,14-17H2,(H2,26,31)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389660
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(4-(2-fluorophenoxy...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2F)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H23FN4O3/c1-2-23(31)30-15-13-29(14-16-30)22-12-11-19(25(27)32)24(28-22)17-7-9-18(10-8-17)33-21-6-4-3-5-20(21)26/h2-12H,1,13-16H2,(H2,27,32)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389663
PNG
(2-(1-acryloylpyrrolidin-3-yl)-4-(4-phenoxyphenyl)t...)
Show SMILES NC(=O)c1sc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H21N3O3S/c1-2-19(27)26-13-12-16(14-26)23-25-20(21(30-23)22(24)28)15-8-10-18(11-9-15)29-17-6-4-3-5-7-17/h2-11,16H,1,12-14H2,(H2,24,28)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389668
PNG
(2-(1-acryloylpiperidin-4-yl)-4-(4-phenoxyphenyl)ox...)
Show SMILES NC(=O)c1oc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H23N3O4/c1-2-20(28)27-14-12-17(13-15-27)24-26-21(22(31-24)23(25)29)16-8-10-19(11-9-16)30-18-6-4-3-5-7-18/h2-11,17H,1,12-15H2,(H2,25,29)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389682
PNG
(2-(4-phenoxyphenyl)-6-(4-(vinylsulfonyl)piperazin-...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Cc2ccccc2)cc1)N1CCN(CC1)S(=O)(=O)C=C
Show InChI InChI=1S/C25H26N4O3S/c1-2-33(31,32)29-16-14-28(15-17-29)23-13-12-22(25(26)30)24(27-23)21-10-8-20(9-11-21)18-19-6-4-3-5-7-19/h2-13H,1,14-18H2,(H2,26,30)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389654
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(3-methoxy-4-methyl...)
Show SMILES COc1cc(ccc1C)-c1nc(ccc1C(N)=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C21H24N4O3/c1-4-19(26)25-11-9-24(10-12-25)18-8-7-16(21(22)27)20(23-18)15-6-5-14(2)17(13-15)28-3/h4-8,13H,1,9-12H2,2-3H3,(H2,22,27)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389666
PNG
(2-(1-acryloylpyrrolidin-3-yl)-5-(4-phenoxyphenyl)t...)
Show SMILES NC(=O)c1nc(sc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H21N3O3S/c1-2-19(27)26-13-12-16(14-26)23-25-20(22(24)28)21(30-23)15-8-10-18(11-9-15)29-17-6-4-3-5-7-17/h2-11,16H,1,12-14H2,(H2,24,28)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390425
PNG
(2-(4-phenoxyphenyl)-6-(1-(vinylsulfonyl)piperidin-...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)S(=O)(=O)C=C
Show InChI InChI=1S/C25H25N3O4S/c1-2-33(30,31)28-16-14-18(15-17-28)23-13-12-22(25(26)29)24(27-23)19-8-10-21(11-9-19)32-20-6-4-3-5-7-20/h2-13,18H,1,14-17H2,(H2,26,29)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389643
PNG
(1-(4-acrylamidophenyl)-3-(4-phenoxyphenyl)-1H-pyra...)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)-c1ccc(NC(=O)C=C)cc1
Show InChI InChI=1S/C25H20N4O3/c1-2-23(30)27-18-10-12-19(13-11-18)29-16-22(25(26)31)24(28-29)17-8-14-21(15-9-17)32-20-6-4-3-5-7-20/h2-16H,1H2,(H2,26,31)(H,27,30)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389644
PNG
(1-(3-aminophenyl)-3-(4-phenoxyphenyl)-1H-pyrazole-...)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)-c1cccc(N)c1
Show InChI InChI=1S/C22H18N4O2/c23-16-5-4-6-17(13-16)26-14-20(22(24)27)21(25-26)15-9-11-19(12-10-15)28-18-7-2-1-3-8-18/h1-14H,23H2,(H2,24,27)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389649
PNG
(2-(1-acryloylpyrrolidin-3-yl)-4-(4-phenoxyphenyl)p...)
Show SMILES NC(=O)c1cnc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H22N4O3/c1-2-21(29)28-13-12-17(15-28)24-26-14-20(23(25)30)22(27-24)16-8-10-19(11-9-16)31-18-6-4-3-5-7-18/h2-11,14,17H,1,12-13,15H2,(H2,25,30)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389658
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(3-fluoro-4-phenoxy...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)c(F)c1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H23FN4O3/c1-2-23(31)30-14-12-29(13-15-30)22-11-9-19(25(27)32)24(28-22)17-8-10-21(20(26)16-17)33-18-6-4-3-5-7-18/h2-11,16H,1,12-15H2,(H2,27,32)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389633
PNG
(6-(1-acryloylpyrrolidin-3-yl)-2-(4-phenoxyphenyl)n...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H23N3O3/c1-2-23(29)28-15-14-18(16-28)22-13-12-21(25(26)30)24(27-22)17-8-10-20(11-9-17)31-19-6-4-3-5-7-19/h2-13,18H,1,14-16H2,(H2,26,30)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389635
PNG
(6-(1-acryloylpiperidin-3-yl)-2-(4-phenoxyphenyl)ni...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H25N3O3/c1-2-24(30)29-16-6-7-19(17-29)23-15-14-22(26(27)31)25(28-23)18-10-12-21(13-11-18)32-20-8-4-3-5-9-20/h2-5,8-15,19H,1,6-7,16-17H2,(H2,27,31)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389669
PNG
(2-(4-acryloylpiperazin-1-yl)-N-methyl-4-(4-phenoxy...)
Show SMILES CNC(=O)c1sc(nc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H24N4O3S/c1-3-20(29)27-13-15-28(16-14-27)24-26-21(22(32-24)23(30)25-2)17-9-11-19(12-10-17)31-18-7-5-4-6-8-18/h3-12H,1,13-16H2,2H3,(H,25,30)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389674
PNG
(2-(1-acryloylpiperidin-3-yl)-5-(4-phenoxyphenyl)ox...)
Show SMILES NC(=O)c1nc(oc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23N3O4/c1-2-20(28)27-14-6-7-17(15-27)24-26-21(23(25)29)22(31-24)16-10-12-19(13-11-16)30-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15H2,(H2,25,29)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389681
PNG
(6-(1-acryloylpiperidin-4-yl)-2-(4-(phenylcarbamoyl...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(cc1)C(=O)Nc1ccccc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C27H26N4O3/c1-2-24(32)31-16-14-18(15-17-31)23-13-12-22(26(28)33)25(30-23)19-8-10-20(11-9-19)27(34)29-21-6-4-3-5-7-21/h2-13,18H,1,14-17H2,(H2,28,33)(H,29,34)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389632
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(4-phenoxyphenyl)ni...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H24N4O3/c1-2-23(30)29-16-14-28(15-17-29)22-13-12-21(25(26)31)24(27-22)18-8-10-20(11-9-18)32-19-6-4-3-5-7-19/h2-13H,1,14-17H2,(H2,26,31)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM303544
PNG
(US10138229, Example 55 | US9951056, Example 12)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H24N4O3/c1-2-22(29)27-14-12-18(13-15-27)28-16-21(24(25)30)23(26-28)17-8-10-20(11-9-17)31-19-6-4-3-5-7-19/h2-11,16,18H,1,12-15H2,(H2,25,30)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389641
PNG
(1-(1-acryloylpyrrolidin-3-yl)-3-(4-phenoxyphenyl)-...)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C23H22N4O3/c1-2-21(28)26-13-12-17(14-26)27-15-20(23(24)29)22(25-27)16-8-10-19(11-9-16)30-18-6-4-3-5-7-18/h2-11,15,17H,1,12-14H2,(H2,24,29)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389648
PNG
(2-(1-acryloylpiperidin-4-yl)-4-(4-phenoxyphenyl)py...)
Show SMILES NC(=O)c1cnc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H24N4O3/c1-2-22(30)29-14-12-18(13-15-29)25-27-16-21(24(26)31)23(28-25)17-8-10-20(11-9-17)32-19-6-4-3-5-7-19/h2-11,16,18H,1,12-15H2,(H2,26,31)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389656
PNG
(1-(1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-3-yl...)
Show SMILES CN(C)C\C=C\C(=O)N1CCC(C1)n1cc(C(N)=O)c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H29N5O3/c1-29(2)15-6-9-24(32)30-16-14-20(17-30)31-18-23(26(27)33)25(28-31)19-10-12-22(13-11-19)34-21-7-4-3-5-8-21/h3-13,18,20H,14-17H2,1-2H3,(H2,27,33)/b9-6+
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389661
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(2-fluoro-4-phenoxy...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1F)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H23FN4O3/c1-2-23(31)30-14-12-29(13-15-30)22-11-10-20(25(27)32)24(28-22)19-9-8-18(16-21(19)26)33-17-6-4-3-5-7-17/h2-11,16H,1,12-15H2,(H2,27,32)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389667
PNG
(2-(1-acryloylpiperidin-3-yl)-5-(4-phenoxyphenyl)th...)
Show SMILES NC(=O)c1nc(sc1-c1ccc(Oc2ccccc2)cc1)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C24H23N3O3S/c1-2-20(28)27-14-6-7-17(15-27)24-26-21(23(25)29)22(31-24)16-10-12-19(13-11-16)30-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15H2,(H2,25,29)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389679
PNG
((E)-1-(1-(2-cyanobut-2-enoyl)azetidin-3-yl)-3-(4-p...)
Show SMILES C\C=C(/C#N)C(=O)N1CC(C1)n1cc(C(N)=O)c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H21N5O3/c1-2-16(12-25)24(31)28-13-18(14-28)29-15-21(23(26)30)22(27-29)17-8-10-20(11-9-17)32-19-6-4-3-5-7-19/h2-11,15,18H,13-14H2,1H3,(H2,26,30)/b16-2+
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389680
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(4-((4,4-difluorocy...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(OC2CCC(F)(F)CC2)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C25H28F2N4O3/c1-2-22(32)31-15-13-30(14-16-31)21-8-7-20(24(28)33)23(29-21)17-3-5-18(6-4-17)34-19-9-11-25(26,27)12-10-19/h2-8,19H,1,9-16H2,(H2,28,33)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389636
PNG
(6-(3-acrylamidopyrrolidin-1-yl)-2-(4-phenoxyphenyl...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)N1CCC(C1)NC(=O)C=C
Show InChI InChI=1S/C25H24N4O3/c1-2-23(30)27-18-14-15-29(16-18)22-13-12-21(25(26)31)24(28-22)17-8-10-20(11-9-17)32-19-6-4-3-5-7-19/h2-13,18H,1,14-16H2,(H2,26,31)(H,27,30)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389627
PNG
(6-(4-acrylamidopiperidin-1-yl)-2-(4-phenoxyphenyl)...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)N1CCC(CC1)NC(=O)C=C
Show InChI InChI=1S/C26H26N4O3/c1-2-24(31)28-19-14-16-30(17-15-19)23-13-12-22(26(27)32)25(29-23)18-8-10-21(11-9-18)33-20-6-4-3-5-7-20/h2-13,19H,1,14-17H2,(H2,27,32)(H,28,31)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389628
PNG
(6-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)py...)
Show SMILES C=CC(=O)N1CCC(CC1)c1ccc(C#N)c(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C26H23N3O2/c1-2-25(30)29-16-14-19(15-17-29)24-13-10-21(18-27)26(28-24)20-8-11-23(12-9-20)31-22-6-4-3-5-7-22/h2-13,19H,1,14-17H2
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389629
PNG
(6-(4-acryloylpiperazin-1-yl)-6′-phenoxy-2,3&...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)nc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C24H23N5O3/c1-2-22(30)29-14-12-28(13-15-29)20-10-9-19(24(25)31)23(27-20)17-8-11-21(26-16-17)32-18-6-4-3-5-7-18/h2-11,16H,1,12-15H2,(H2,25,31)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389617
PNG
(2-(4-phenoxyphenyl)-6-(piperidin-4-yl)nicotinamide...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCNCC1
Show InChI InChI=1S/C23H23N3O2/c24-23(27)20-10-11-21(16-12-14-25-15-13-16)26-22(20)17-6-8-19(9-7-17)28-18-4-2-1-3-5-18/h1-11,16,25H,12-15H2,(H2,24,27)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389623
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(4-chlorophenyl)nic...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Cl)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C19H19ClN4O2/c1-2-17(25)24-11-9-23(10-12-24)16-8-7-15(19(21)26)18(22-16)13-3-5-14(20)6-4-13/h2-8H,1,9-12H2,(H2,21,26)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389617
PNG
(2-(4-phenoxyphenyl)-6-(piperidin-4-yl)nicotinamide...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccccc2)cc1)C1CCNCC1
Show InChI InChI=1S/C23H23N3O2/c24-23(27)20-10-11-21(16-12-14-25-15-13-16)26-22(20)17-6-8-19(9-7-17)28-18-4-2-1-3-5-18/h1-11,16,25H,12-15H2,(H2,24,27)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389621
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(4-(4-cyanophenoxy)...)
Show SMILES NC(=O)c1ccc(nc1-c1ccc(Oc2ccc(cc2)C#N)cc1)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C26H23N5O3/c1-2-24(32)31-15-13-30(14-16-31)23-12-11-22(26(28)33)25(29-23)19-5-9-21(10-6-19)34-20-7-3-18(17-27)4-8-20/h2-12H,1,13-16H2,(H2,28,33)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389622
PNG
(6-(4-acryloylpiperazin-1-yl)-2-(4-fluoro-3-methoxy...)
Show SMILES COc1cc(ccc1F)-c1nc(ccc1C(N)=O)N1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C20H21FN4O3/c1-3-18(26)25-10-8-24(9-11-25)17-7-5-14(20(22)27)19(23-17)13-4-6-15(21)16(12-13)28-2/h3-7,12H,1,8-11H2,2H3,(H2,22,27)
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BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389626
PNG
(5-(1-acryloylpiperidin-4-yl)-1-(4-phenoxyphenyl)-1...)
Show SMILES NC(=O)c1cc(C2CCN(CC2)C(=O)C=C)n(n1)-c1ccc(Oc2ccccc2)cc1
Show InChI InChI=1S/C24H24N4O3/c1-2-23(29)27-14-12-17(13-15-27)22-16-21(24(25)30)26-28(22)18-8-10-20(11-9-18)31-19-6-4-3-5-7-19/h2-11,16-17H,1,12-15H2,(H2,25,30)
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US Patent
n/an/a>1.00E+3n/an/an/an/an/an/a



BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389620
PNG
(1-(azetidin-3-yl)-3-(4-phenoxyphenyl)-1H-pyrazole-...)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)C1CNC1
Show InChI InChI=1S/C19H18N4O2/c20-19(24)17-12-23(14-10-21-11-14)22-18(17)13-6-8-16(9-7-13)25-15-4-2-1-3-5-15/h1-9,12,14,21H,10-11H2,(H2,20,24)
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n/an/a>1.00E+3n/an/an/an/an/an/a



BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389624
PNG
(1-(1-(2-cyanoacetyl)azetidin-3-yl)-3-(4-phenoxyphe...)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)C1CN(C1)C(=O)CC#N
Show InChI InChI=1S/C22H19N5O3/c23-11-10-20(28)26-12-16(13-26)27-14-19(22(24)29)21(25-27)15-6-8-18(9-7-15)30-17-4-2-1-3-5-17/h1-9,14,16H,10,12-13H2,(H2,24,29)
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n/an/a>1.00E+3n/an/an/an/an/an/a



BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389625
PNG
((E)-1-(1-(2-cyano-3-cyclopropylacryloyl)azetidin-3...)
Show SMILES NC(=O)c1cn(nc1-c1ccc(Oc2ccccc2)cc1)C1CN(C1)C(=O)C(=C\C1CC1)\C#N
Show InChI InChI=1S/C26H23N5O3/c27-13-19(12-17-6-7-17)26(33)30-14-20(15-30)31-16-23(25(28)32)24(29-31)18-8-10-22(11-9-18)34-21-4-2-1-3-5-21/h1-5,8-12,16-17,20H,6-7,14-15H2,(H2,28,32)/b19-12+
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n/an/a>1.00E+3n/an/an/an/an/an/a



BEIJING INNOCARE PHARMA TECH CO., LTD.

US Patent


Assay Description
1 and 2 assay buffer were made at first. BTK kinase was diluted with 1 assay buffer but substrate was diluted with 2 assay buffer. 1 ul of dilute...


US Patent US9951056 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%