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Patent code US9951063

Compile Data Set for Download or QSAR
Found 147 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389791
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-2-methyl-4-[2-...)
Show SMILES CCCc1ncc(cn1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C29H34N8O/c1-3-6-27-31-15-23(16-32-27)34-12-10-22-7-4-9-26(24(22)18-34)35-13-14-37(21(2)17-35)28(38)19-36-20-33-25-8-5-11-30-29(25)36/h4-5,7-9,11,15-16,20-21H,3,6,10,12-14,17-19H2,1-2H3/t21-/m1/s1
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US Patent
n/an/a 0.850n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389773
PNG
(US9951063, 92)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ccc(C)nc1
Show InChI InChI=1S/C28H31N7O/c1-20-8-9-23(15-30-20)32-12-10-22-5-3-7-26(24(22)17-32)33-13-14-35(21(2)16-33)27(36)18-34-19-31-25-6-4-11-29-28(25)34/h3-9,11,15,19,21H,10,12-14,16-18H2,1-2H3/t21-/m1/s1
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UniChem
US Patent
n/an/a 0.970n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389781
PNG
(US9951063, 100)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C28H28F3N7O/c1-19-15-36(12-13-38(19)26(39)17-37-18-34-23-5-3-10-32-27(23)37)24-6-2-4-20-9-11-35(16-22(20)24)21-7-8-25(33-14-21)28(29,30)31/h2-8,10,14,18-19H,9,11-13,15-17H2,1H3/t19-/m1/s1
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US Patent
n/an/a 1.25n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389729
PNG
(1-{(R)-4-[2-(2-Cyclopropyl-pyrimidin-5-yl)-5-trifl...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1ccc(C)n1)c1ccc(c2CCN(Cc12)c1cnc(nc1)C1CC1)C(F)(F)F
Show InChI InChI=1S/C28H32F3N7O/c1-18-7-10-37(34-18)17-26(39)38-12-11-36(15-19(38)2)25-6-5-24(28(29,30)31)22-8-9-35(16-23(22)25)21-13-32-27(33-14-21)20-3-4-20/h5-7,10,13-14,19-20H,3-4,8-9,11-12,15-17H2,1-2H3/t19-/m1/s1
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US Patent
n/an/a 1.40n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389788
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-2-methyl-4-[2-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C27H27F3N8O/c1-18-14-36(10-11-38(18)24(39)16-37-17-34-22-5-3-8-31-25(22)37)23-6-2-4-19-7-9-35(15-21(19)23)20-12-32-26(33-13-20)27(28,29)30/h2-6,8,12-13,17-18H,7,9-11,14-16H2,1H3/t18-/m1/s1
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US Patent
n/an/a 1.74n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389801
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-4-[2-(6-methox...)
Show SMILES COc1cncc(n1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C27H30N8O2/c1-19-15-32(11-12-35(19)26(36)17-34-18-30-22-6-4-9-29-27(22)34)23-7-3-5-20-8-10-33(16-21(20)23)24-13-28-14-25(31-24)37-2/h3-7,9,13-14,18-19H,8,10-12,15-17H2,1-2H3/t19-/m1/s1
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US Patent
n/an/a 2.03n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389731
PNG
(1-{(R)-4-[2-(2-Dimethylamino-pyrimidin-5-yl)-5-tri...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1ccc(c2CCN(Cc12)c1cnc(nc1)N(C)C)C(F)(F)F
Show InChI InChI=1S/C27H34F3N9O/c1-17-14-37(10-11-38(17)25(40)16-39-19(3)33-18(2)34-39)24-7-6-23(27(28,29)30)21-8-9-36(15-22(21)24)20-12-31-26(32-13-20)35(4)5/h6-7,12-13,17H,8-11,14-16H2,1-5H3/t17-/m1/s1
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US Patent
n/an/a 2.26n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389709
PNG
(US9951063, 28)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN(CC1)C(=O)Cn1cnc2cccnc12
Show InChI InChI=1S/C28H29F3N8O2/c1-2-41-27-33-14-19(15-34-27)38-9-7-20-21(16-38)24(6-5-22(20)28(29,30)31)36-10-12-37(13-11-36)25(40)17-39-18-35-23-4-3-8-32-26(23)39/h3-6,8,14-15,18H,2,7,9-13,16-17H2,1H3
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US Patent
n/an/a 2.40n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389793
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-((R)-2-methyl-4-{2-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1cnc(OCC(F)(F)F)nc1
Show InChI InChI=1S/C28H29F3N8O2/c1-19-14-37(10-11-39(19)25(40)16-38-18-35-23-5-3-8-32-26(23)38)24-6-2-4-20-7-9-36(15-22(20)24)21-12-33-27(34-13-21)41-17-28(29,30)31/h2-6,8,12-13,18-19H,7,9-11,14-17H2,1H3/t19-/m1/s1
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US Patent
n/an/a 2.98n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389810
PNG
(US9951063, 129)
Show SMILES CCOc1ncc(cn1)N1CCc2c(F)ccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C28H31FN8O2/c1-3-39-28-31-13-20(14-32-28)34-10-8-21-22(16-34)25(7-6-23(21)29)35-11-12-37(19(2)15-35)26(38)17-36-18-33-24-5-4-9-30-27(24)36/h4-7,9,13-14,18-19H,3,8,10-12,15-17H2,1-2H3/t19-/m1/s1
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US Patent
n/an/a 3.10n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389802
PNG
(1-{(R)-4-[2-(4,6-Dimethoxy-[1,3,5]triazin-2-yl)-1,...)
Show SMILES COc1nc(OC)nc(n1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C27H31N9O3/c1-18-14-33(12-13-36(18)23(37)16-35-17-29-21-7-5-10-28-24(21)35)22-8-4-6-19-9-11-34(15-20(19)22)25-30-26(38-2)32-27(31-25)39-3/h4-8,10,17-18H,9,11-16H2,1-3H3/t18-/m1/s1
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UniChem
US Patent
n/an/a 3.39n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389730
PNG
(1-{(R)-4-[2-(2-Cyclopropyl-pyrimidin-5-yl)-5-trifl...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nccc1C)c1ccc(c2CCN(Cc12)c1cnc(nc1)C1CC1)C(F)(F)F
Show InChI InChI=1S/C28H32F3N7O/c1-18-7-9-34-38(18)17-26(39)37-12-11-36(15-19(37)2)25-6-5-24(28(29,30)31)22-8-10-35(16-23(22)25)21-13-32-27(33-14-21)20-3-4-20/h5-7,9,13-14,19-20H,3-4,8,10-12,15-17H2,1-2H3/t19-/m1/s1
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US Patent
n/an/a 3.56n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389696
PNG
(US9951063, 15)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1cnc(nc1)C1CC1)C(F)(F)F
Show InChI InChI=1S/C29H34F3N7O/c1-18-12-19(2)39(35-18)17-27(40)38-11-10-37(15-20(38)3)26-7-6-25(29(30,31)32)23-8-9-36(16-24(23)26)22-13-33-28(34-14-22)21-4-5-21/h6-7,12-14,20-21H,4-5,8-11,15-17H2,1-3H3/t20-/m1/s1
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US Patent
n/an/a 3.58n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389705
PNG
(US9951063, 24)
Show SMILES COc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1nc(C)cc1C
Show InChI InChI=1S/C27H32F3N7O2/c1-17-11-18(2)37(33-17)16-25(38)36-10-9-35(14-19(36)3)24-6-5-23(27(28,29)30)21-7-8-34(15-22(21)24)20-12-31-26(39-4)32-13-20/h5-6,11-13,19H,7-10,14-16H2,1-4H3/t19-/m1/s1
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US Patent
n/an/a 3.70n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389798
PNG
(2-{8-[(R)-4-(2-Imidazo[4,5-b]pyridin-3-yl-acetyl)-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1nc(cs1)C#N
Show InChI InChI=1S/C26H26N8OS/c1-18-13-31(10-11-34(18)24(35)15-33-17-29-22-5-3-8-28-25(22)33)23-6-2-4-19-7-9-32(14-21(19)23)26-30-20(12-27)16-36-26/h2-6,8,16-18H,7,9-11,13-15H2,1H3/t18-/m1/s1
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PC sid
UniChem
US Patent
n/an/a 3.70n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389807
PNG
(US9951063, 126)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1cccc2CCN(Cc12)c1cnc(nc1)C1CC1
Show InChI InChI=1S/C27H34N8O/c1-18-15-33(11-12-34(18)26(36)17-35-20(3)30-19(2)31-35)25-6-4-5-21-9-10-32(16-24(21)25)23-13-28-27(29-14-23)22-7-8-22/h4-6,13-14,18,22H,7-12,15-17H2,1-3H3/t18-/m1/s1
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US Patent
n/an/a 3.98n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389733
PNG
(1-{(R)-4-[2-(2-Dimethylamino-pyrimidin-5-yl)-5-tri...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nccc1C)c1ccc(c2CCN(Cc12)c1cnc(nc1)N(C)C)C(F)(F)F
Show InChI InChI=1S/C27H33F3N8O/c1-18-7-9-33-38(18)17-25(39)37-12-11-36(15-19(37)2)24-6-5-23(27(28,29)30)21-8-10-35(16-22(21)24)20-13-31-26(32-14-20)34(3)4/h5-7,9,13-14,19H,8,10-12,15-17H2,1-4H3/t19-/m1/s1
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US Patent
n/an/a 4.10n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389727
PNG
(1-{(R)-4-[2-(2-Cyclopropyl-pyrimidin-5-yl)-5-trifl...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1ccc(c2CCN(Cc12)c1cnc(nc1)C1CC1)C(F)(F)F
Show InChI InChI=1S/C28H33F3N8O/c1-17-14-37(10-11-38(17)26(40)16-39-19(3)34-18(2)35-39)25-7-6-24(28(29,30)31)22-8-9-36(15-23(22)25)21-12-32-27(33-13-21)20-4-5-20/h6-7,12-13,17,20H,4-5,8-11,14-16H2,1-3H3/t17-/m1/s1
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PC sid
UniChem
US Patent
n/an/a 4.37n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389778
PNG
(US9951063, 97)
Show SMILES COc1cccc(c1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C29H32N6O2/c1-21-17-33(14-15-35(21)28(36)19-34-20-31-26-9-5-12-30-29(26)34)27-10-3-6-22-11-13-32(18-25(22)27)23-7-4-8-24(16-23)37-2/h3-10,12,16,20-21H,11,13-15,17-19H2,1-2H3/t21-/m1/s1
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PC sid
UniChem
US Patent
n/an/a 4.38n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389639
PNG
(US9951063, 1)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1ncc(Cn2cccn2)s1)C(F)(F)F
Show InChI InChI=1S/C29H33F3N8OS/c1-19-13-20(2)40(35-19)18-27(41)39-12-11-36(15-21(39)3)26-6-5-25(29(30,31)32)23-7-10-37(17-24(23)26)28-33-14-22(42-28)16-38-9-4-8-34-38/h4-6,8-9,13-14,21H,7,10-12,15-18H2,1-3H3/t21-/m1/s1
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n/an/a 4.47n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389804
PNG
(US9951063, 123)
Show SMILES CCOc1ncc(cn1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C28H32N8O2/c1-3-38-28-30-14-22(15-31-28)33-11-9-21-6-4-8-25(23(21)17-33)34-12-13-36(20(2)16-34)26(37)18-35-19-32-24-7-5-10-29-27(24)35/h4-8,10,14-15,19-20H,3,9,11-13,16-18H2,1-2H3/t20-/m1/s1
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n/an/a 4.71n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389792
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-4-[2-(2-isopro...)
Show SMILES CC(C)Oc1ncc(cn1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C29H34N8O2/c1-20(2)39-29-31-14-23(15-32-29)34-11-9-22-6-4-8-26(24(22)17-34)35-12-13-37(21(3)16-35)27(38)18-36-19-33-25-7-5-10-30-28(25)36/h4-8,10,14-15,19-21H,9,11-13,16-18H2,1-3H3/t21-/m1/s1
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n/an/a 4.83n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389732
PNG
(1-{(R)-4-[2-(2-Dimethylamino-pyrimidin-5-yl)-5-tri...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1ccc(C)n1)c1ccc(c2CCN(Cc12)c1cnc(nc1)N(C)C)C(F)(F)F
Show InChI InChI=1S/C27H33F3N8O/c1-18-7-10-37(33-18)17-25(39)38-12-11-36(15-19(38)2)24-6-5-23(27(28,29)30)21-8-9-35(16-22(21)24)20-13-31-26(32-14-20)34(3)4/h5-7,10,13-14,19H,8-9,11-12,15-17H2,1-4H3/t19-/m1/s1
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n/an/a 4.93n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389814
PNG
(US9951063, 133)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1ccc(F)c2CCN(Cc12)c1cnc(nc1)C1CC1
Show InChI InChI=1S/C27H33FN8O/c1-17-14-34(10-11-35(17)26(37)16-36-19(3)31-18(2)32-36)25-7-6-24(28)22-8-9-33(15-23(22)25)21-12-29-27(30-13-21)20-4-5-20/h6-7,12-13,17,20H,4-5,8-11,14-16H2,1-3H3/t17-/m1/s1
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n/an/a 5.42n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389787
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-[(R)-2-methyl-4-(2-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1cncnc1
Show InChI InChI=1S/C26H28N8O/c1-19-14-32(10-11-34(19)25(35)16-33-18-30-23-5-3-8-29-26(23)33)24-6-2-4-20-7-9-31(15-22(20)24)21-12-27-17-28-13-21/h2-6,8,12-13,17-19H,7,9-11,14-16H2,1H3/t19-/m1/s1
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n/an/a 5.46n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389811
PNG
(US9951063, 130)
Show SMILES CCOc1ncc(cn1)N1CCc2c(F)ccc(N3CCN([C@H](C)C3)C(=O)Cn3nc(C)cc3C)c2C1
Show InChI InChI=1S/C27H34FN7O2/c1-5-37-27-29-13-21(14-30-27)32-9-8-22-23(16-32)25(7-6-24(22)28)33-10-11-34(20(4)15-33)26(36)17-35-19(3)12-18(2)31-35/h6-7,12-14,20H,5,8-11,15-17H2,1-4H3/t20-/m1/s1
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n/an/a 5.70n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389683
PNG
(US9951063, 2)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1nc(cs1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H28F6N6OS/c1-15-10-16(2)38(34-15)13-23(39)37-9-8-35(11-17(37)3)21-5-4-20(25(27,28)29)18-6-7-36(12-19(18)21)24-33-22(14-40-24)26(30,31)32/h4-5,10,14,17H,6-9,11-13H2,1-3H3/t17-/m1/s1
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n/an/a 6.07n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389734
PNG
(US9951063, 53)
Show SMILES CNc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1ncc2cccnc12
Show InChI InChI=1S/C28H30F3N9O/c1-18-15-38(10-11-39(18)25(41)17-40-26-19(12-36-40)4-3-8-33-26)24-6-5-23(28(29,30)31)21-7-9-37(16-22(21)24)20-13-34-27(32-2)35-14-20/h3-6,8,12-14,18H,7,9-11,15-17H2,1-2H3,(H,32,34,35)/t18-/m1/s1
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n/an/a 6.15n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389697
PNG
(US9951063, 16)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1ccc(c2CCN(Cc12)c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C29H29F3N6O/c1-20-16-36(14-15-38(20)27(39)18-37-19-34-25-8-5-12-33-28(25)37)26-10-9-24(29(30,31)32)22-11-13-35(17-23(22)26)21-6-3-2-4-7-21/h2-10,12,19-20H,11,13-18H2,1H3/t20-/m1/s1
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n/an/a 6.19n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389735
PNG
(US9951063, 54)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1nc(C)nc1C
Show InChI InChI=1S/C27H33F3N8O2/c1-5-40-26-31-12-20(13-32-26)35-9-8-21-22(15-35)24(7-6-23(21)27(28,29)30)36-10-11-37(17(2)14-36)25(39)16-38-19(4)33-18(3)34-38/h6-7,12-13,17H,5,8-11,14-16H2,1-4H3/t17-/m1/s1
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n/an/a 6.22n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389717
PNG
(US9951063, 36)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@@H](C)C1)C(=O)Cn1ccc(C)n1
Show InChI InChI=1S/C27H32F3N7O2/c1-4-39-26-31-13-20(14-32-26)34-9-8-21-22(16-34)24(6-5-23(21)27(28,29)30)35-11-12-37(19(3)15-35)25(38)17-36-10-7-18(2)33-36/h5-7,10,13-14,19H,4,8-9,11-12,15-17H2,1-3H3/t19-/m0/s1
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n/an/a 6.27n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389799
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-4-[2-(2-methox...)
Show SMILES COc1ncc(cn1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C27H30N8O2/c1-19-15-33(11-12-35(19)25(36)17-34-18-31-23-6-4-9-28-26(23)34)24-7-3-5-20-8-10-32(16-22(20)24)21-13-29-27(37-2)30-14-21/h3-7,9,13-14,18-19H,8,10-12,15-17H2,1-2H3/t19-/m1/s1
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n/an/a 6.49n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389692
PNG
(US9951063, 11)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1nc2ccc(cc2s1)C#N)C(F)(F)F
Show InChI InChI=1S/C30H30F3N7OS/c1-18-12-19(2)40(36-18)17-28(41)39-11-10-37(15-20(39)3)26-7-5-24(30(31,32)33)22-8-9-38(16-23(22)26)29-35-25-6-4-21(14-34)13-27(25)42-29/h4-7,12-13,20H,8-11,15-17H2,1-3H3/t20-/m1/s1
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n/an/a 6.58n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389728
PNG
(1-{(R)-4-[2-(2-Cyclopropyl-pyrimidin-5-yl)-5-trifl...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1ncc2cccnc12)c1ccc(c2CCN(Cc12)c1cnc(nc1)C1CC1)C(F)(F)F
Show InChI InChI=1S/C30H31F3N8O/c1-19-16-39(11-12-40(19)27(42)18-41-29-21(13-37-41)3-2-9-34-29)26-7-6-25(30(31,32)33)23-8-10-38(17-24(23)26)22-14-35-28(36-15-22)20-4-5-20/h2-3,6-7,9,13-15,19-20H,4-5,8,10-12,16-18H2,1H3/t19-/m1/s1
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n/an/a 7.27n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389774
PNG
(US9951063, 93)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ccc(Cl)cc1
Show InChI InChI=1S/C28H29ClN6O/c1-20-16-33(14-15-35(20)27(36)18-34-19-31-25-5-3-12-30-28(25)34)26-6-2-4-21-11-13-32(17-24(21)26)23-9-7-22(29)8-10-23/h2-10,12,19-20H,11,13-18H2,1H3/t20-/m1/s1
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n/an/a 7.55n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389701
PNG
(US9951063, 20)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12
Show InChI InChI=1S/C29H31F3N8O2/c1-3-42-28-34-13-20(14-35-28)37-10-8-21-22(16-37)25(7-6-23(21)29(30,31)32)38-11-12-40(19(2)15-38)26(41)17-39-18-36-24-5-4-9-33-27(24)39/h4-7,9,13-14,18-19H,3,8,10-12,15-17H2,1-2H3/t19-/m1/s1
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n/an/a 7.77n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389776
PNG
(US9951063, 95)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ccc(cc1)C#N
Show InChI InChI=1S/C29H29N7O/c1-21-17-34(14-15-36(21)28(37)19-35-20-32-26-5-3-12-31-29(26)35)27-6-2-4-23-11-13-33(18-25(23)27)24-9-7-22(16-30)8-10-24/h2-10,12,20-21H,11,13-15,17-19H2,1H3/t21-/m1/s1
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n/an/a 7.80n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389741
PNG
(US9951063, 60)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C30H32N6O3/c1-22-17-33(15-16-36(22)28(37)19-35-21-32-26-10-6-13-31-29(26)35)27-11-5-9-24-12-14-34(18-25(24)27)30(38)39-20-23-7-3-2-4-8-23/h2-11,13,21-22H,12,14-20H2,1H3/t22-/m1/s1
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n/an/a 7.94n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389809
PNG
(US9951063, 128)
Show SMILES CCOc1ncc(cn1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3nc(C)cc3C)c2C1
Show InChI InChI=1S/C27H35N7O2/c1-5-36-27-28-14-23(15-29-27)31-10-9-22-7-6-8-25(24(22)17-31)32-11-12-33(21(4)16-32)26(35)18-34-20(3)13-19(2)30-34/h6-8,13-15,21H,5,9-12,16-18H2,1-4H3/t21-/m1/s1
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n/an/a 7.94n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389772
PNG
(US9951063, 91)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ccc(F)cn1
Show InChI InChI=1S/C27H28FN7O/c1-19-15-32(12-13-35(19)26(36)17-34-18-31-23-5-3-10-29-27(23)34)24-6-2-4-20-9-11-33(16-22(20)24)25-8-7-21(28)14-30-25/h2-8,10,14,18-19H,9,11-13,15-17H2,1H3/t19-/m1/s1
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n/an/a 8.01n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389737
PNG
(US9951063, 56)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1ncc(o1)-c1ccccc1)C(F)(F)F
Show InChI InChI=1S/C31H33F3N6O2/c1-20-15-21(2)40(36-20)19-29(41)39-14-13-37(17-22(39)3)27-10-9-26(31(32,33)34)24-11-12-38(18-25(24)27)30-35-16-28(42-30)23-7-5-4-6-8-23/h4-10,15-16,22H,11-14,17-19H2,1-3H3/t22-/m1/s1
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n/an/a 8.14n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389723
PNG
(2-(3,5-Dimethyl-[1,2,4]triazol-1-yl)-1-{(R)-2-meth...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1ccc(c2CCN(Cc12)c1nc(cs1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H27F6N7OS/c1-14-10-35(8-9-37(14)22(39)12-38-16(3)32-15(2)34-38)20-5-4-19(24(26,27)28)17-6-7-36(11-18(17)20)23-33-21(13-40-23)25(29,30)31/h4-5,13-14H,6-12H2,1-3H3/t14-/m1/s1
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n/an/a 8.29n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389780
PNG
(US9951063, 99)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ccc(F)cc1
Show InChI InChI=1S/C28H29FN6O/c1-20-16-33(14-15-35(20)27(36)18-34-19-31-25-5-3-12-30-28(25)34)26-6-2-4-21-11-13-32(17-24(21)26)23-9-7-22(29)8-10-23/h2-10,12,19-20H,11,13-18H2,1H3/t20-/m1/s1
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n/an/a 8.30n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389694
PNG
(US9951063, 13)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1cnc(nc1)N(C)C)C(F)(F)F
Show InChI InChI=1S/C28H35F3N8O/c1-18-12-19(2)39(34-18)17-26(40)38-11-10-37(15-20(38)3)25-7-6-24(28(29,30)31)22-8-9-36(16-23(22)25)21-13-32-27(33-14-21)35(4)5/h6-7,12-14,20H,8-11,15-17H2,1-5H3/t20-/m1/s1
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n/an/a 8.48n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389828
PNG
(US9951063, 147)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1cc(F)c(F)c2CCN(Cc12)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H27F5N8O/c1-14-11-36(6-7-37(14)22(39)13-38-16(3)33-15(2)34-38)21-8-20(26)23(27)18-4-5-35(12-19(18)21)17-9-31-24(32-10-17)25(28,29)30/h8-10,14H,4-7,11-13H2,1-3H3/t14-/m1/s1
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n/an/a 8.58n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389689
PNG
(US9951063, 8)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1ncc(s1)C#N)C(F)(F)F
Show InChI InChI=1S/C26H28F3N7OS/c1-16-10-17(2)36(32-16)15-24(37)35-9-8-33(13-18(35)3)23-5-4-22(26(27,28)29)20-6-7-34(14-21(20)23)25-31-12-19(11-30)38-25/h4-5,10,12,18H,6-9,13-15H2,1-3H3/t18-/m1/s1
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n/an/a 8.88n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389818
PNG
(US9951063, 137)
Show SMILES O=C(Cn1cnc2cccnc12)N1CCN(CC1)c1cccc2CCN(Cc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C29H30N6O3/c36-27(19-35-21-31-25-9-5-12-30-28(25)35)33-16-14-32(15-17-33)26-10-4-8-23-11-13-34(18-24(23)26)29(37)38-20-22-6-2-1-3-7-22/h1-10,12,21H,11,13-20H2
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n/an/a 9.10n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389698
PNG
(US9951063, 17)
Show SMILES COc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12
Show InChI InChI=1S/C28H29F3N8O2/c1-18-14-37(10-11-39(18)25(40)16-38-17-35-23-4-3-8-32-26(23)38)24-6-5-22(28(29,30)31)20-7-9-36(15-21(20)24)19-12-33-27(41-2)34-13-19/h3-6,8,12-13,17-18H,7,9-11,14-16H2,1-2H3/t18-/m1/s1
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n/an/a 9.20n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389693
PNG
(US9951063, 12)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1nc2ccccc2o1)C(F)(F)F
Show InChI InChI=1S/C29H31F3N6O2/c1-18-14-19(2)38(34-18)17-27(39)37-13-12-35(15-20(37)3)25-9-8-23(29(30,31)32)21-10-11-36(16-22(21)25)28-33-24-6-4-5-7-26(24)40-28/h4-9,14,20H,10-13,15-17H2,1-3H3/t20-/m1/s1
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n/an/a 9.39n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389691
PNG
(US9951063, 10)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1nc2ccc(F)cc2s1)C(F)(F)F
Show InChI InChI=1S/C29H30F4N6OS/c1-17-12-18(2)39(35-17)16-27(40)38-11-10-36(14-19(38)3)25-7-5-23(29(31,32)33)21-8-9-37(15-22(21)25)28-34-24-6-4-20(30)13-26(24)41-28/h4-7,12-13,19H,8-11,14-16H2,1-3H3/t19-/m1/s1
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n/an/a 9.45n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389795
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-2-methyl-4-[2-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1nc(C)cs1
Show InChI InChI=1S/C26H29N7OS/c1-18-16-35-26(29-18)31-10-8-20-5-3-7-23(21(20)14-31)30-11-12-33(19(2)13-30)24(34)15-32-17-28-22-6-4-9-27-25(22)32/h3-7,9,16-17,19H,8,10-15H2,1-2H3/t19-/m1/s1
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n/an/a 9.53n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389785
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-[(R)-2-methyl-4-(2-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)C1N(CCc2ccccc12)c1ccccn1
Show InChI InChI=1S/C27H29N7O/c1-20-17-31(15-16-33(20)25(35)18-32-19-30-23-9-6-13-29-26(23)32)27-22-8-3-2-7-21(22)11-14-34(27)24-10-4-5-12-28-24/h2-10,12-13,19-20,27H,11,14-18H2,1H3/t20-,27?/m1/s1
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n/an/a 9.71n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389713
PNG
(US9951063, 32)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN(CC1)C(=O)Cn1cc2cccnc2n1
Show InChI InChI=1S/C28H29F3N8O2/c1-2-41-27-33-14-20(15-34-27)38-9-7-21-22(17-38)24(6-5-23(21)28(29,30)31)36-10-12-37(13-11-36)25(40)18-39-16-19-4-3-8-32-26(19)35-39/h3-6,8,14-16H,2,7,9-13,17-18H2,1H3
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n/an/a 9.83n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389736
PNG
(US9951063, 55)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1nc(C)cc1C
Show InChI InChI=1S/C28H34F3N7O2/c1-5-40-27-32-13-21(14-33-27)35-9-8-22-23(16-35)25(7-6-24(22)28(29,30)31)36-10-11-37(20(4)15-36)26(39)17-38-19(3)12-18(2)34-38/h6-7,12-14,20H,5,8-11,15-17H2,1-4H3/t20-/m1/s1
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n/an/a 10n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389703
PNG
(US9951063, 22)
Show SMILES CCCc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12
Show InChI InChI=1S/C30H33F3N8O/c1-3-5-27-35-14-21(15-36-27)38-11-9-22-23(17-38)26(8-7-24(22)30(31,32)33)39-12-13-41(20(2)16-39)28(42)18-40-19-37-25-6-4-10-34-29(25)40/h4,6-8,10,14-15,19-20H,3,5,9,11-13,16-18H2,1-2H3/t20-/m1/s1
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n/an/a 10.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389800
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-4-[2-(6-methox...)
Show SMILES COc1ccc(nn1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C27H30N8O2/c1-19-15-32(13-14-35(19)26(36)17-34-18-29-22-6-4-11-28-27(22)34)23-7-3-5-20-10-12-33(16-21(20)23)24-8-9-25(37-2)31-30-24/h3-9,11,18-19H,10,12-17H2,1-2H3/t19-/m1/s1
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n/an/a 10.9n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389714
PNG
(US9951063, 33)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN(CC1)C(=O)CN1C(=O)Cc2ccccc12
Show InChI InChI=1S/C30H31F3N6O3/c1-2-42-29-34-16-21(17-35-29)38-10-9-22-23(18-38)26(8-7-24(22)30(31,32)33)36-11-13-37(14-12-36)28(41)19-39-25-6-4-3-5-20(25)15-27(39)40/h3-8,16-17H,2,9-15,18-19H2,1H3
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n/an/a 10.9n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389686
PNG
(US9951063, 5)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1nc(cs1)-c1ccccn1)C(F)(F)F
Show InChI InChI=1S/C30H32F3N7OS/c1-19-14-20(2)40(36-19)17-28(41)39-13-12-37(15-21(39)3)27-8-7-24(30(31,32)33)22-9-11-38(16-23(22)27)29-35-26(18-42-29)25-6-4-5-10-34-25/h4-8,10,14,18,21H,9,11-13,15-17H2,1-3H3/t21-/m1/s1
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n/an/a 11n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389771
PNG
(US9951063, 90)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ccc(C)cn1
Show InChI InChI=1S/C28H31N7O/c1-20-8-9-26(30-15-20)33-12-10-22-5-3-7-25(23(22)17-33)32-13-14-35(21(2)16-32)27(36)18-34-19-31-24-6-4-11-29-28(24)34/h3-9,11,15,19,21H,10,12-14,16-18H2,1-2H3/t21-/m1/s1
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n/an/a 11.2n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389712
PNG
(US9951063, 31)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN(CC1)C(=O)Cn1ncc2cccnc12
Show InChI InChI=1S/C28H29F3N8O2/c1-2-41-27-33-15-20(16-34-27)38-9-7-21-22(17-38)24(6-5-23(21)28(29,30)31)36-10-12-37(13-11-36)25(40)18-39-26-19(14-35-39)4-3-8-32-26/h3-6,8,14-16H,2,7,9-13,17-18H2,1H3
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n/an/a 11.5n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389779
PNG
(US9951063, 98)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C29H29F3N6O2/c1-20-16-36(14-15-38(20)27(39)18-37-19-34-25-5-3-12-33-28(25)37)26-6-2-4-21-11-13-35(17-24(21)26)22-7-9-23(10-8-22)40-29(30,31)32/h2-10,12,19-20H,11,13-18H2,1H3/t20-/m1/s1
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n/an/a 11.6n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389700
PNG
(US9951063, 19)
Show SMILES COc1nc(OC)nc(n1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12
Show InChI InChI=1S/C28H30F3N9O3/c1-17-13-37(11-12-40(17)23(41)15-39-16-33-21-5-4-9-32-24(21)39)22-7-6-20(28(29,30)31)18-8-10-38(14-19(18)22)25-34-26(42-2)36-27(35-25)43-3/h4-7,9,16-17H,8,10-15H2,1-3H3/t17-/m1/s1
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n/an/a 11.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389725
PNG
(2-(3-Methyl-pyrazol-1-yl)-1-{(R)-2-methyl-4-[5-tri...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1ccc(C)n1)c1ccc(c2CCN(Cc12)c1nc(cs1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H26F6N6OS/c1-15-5-8-36(33-15)13-22(38)37-10-9-34(11-16(37)2)20-4-3-19(24(26,27)28)17-6-7-35(12-18(17)20)23-32-21(14-39-23)25(29,30)31/h3-5,8,14,16H,6-7,9-13H2,1-2H3/t16-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389794
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-[(R)-2-methyl-4-(2-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1nccs1
Show InChI InChI=1S/C25H27N7OS/c1-18-14-29(11-12-32(18)23(33)16-31-17-28-21-5-3-8-26-24(21)31)22-6-2-4-19-7-10-30(15-20(19)22)25-27-9-13-34-25/h2-6,8-9,13,17-18H,7,10-12,14-16H2,1H3/t18-/m1/s1
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n/an/a 12.2n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389740
PNG
(US9951063, 59)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1ccc(c2CCN(Cc12)c1cnc(nc1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C26H28F6N8O/c1-15-12-38(8-9-39(15)23(41)14-40-17(3)35-16(2)36-40)22-5-4-21(25(27,28)29)19-6-7-37(13-20(19)22)18-10-33-24(34-11-18)26(30,31)32/h4-5,10-11,15H,6-9,12-14H2,1-3H3/t15-/m1/s1
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n/an/a 12.3n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389819
PNG
(US9951063, 138)
Show SMILES O=C(Cn1ccc2cccnc12)N1CCN(CC1)c1cccc2CCN(Cc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C30H31N5O3/c36-28(21-34-14-12-25-9-5-13-31-29(25)34)33-18-16-32(17-19-33)27-10-4-8-24-11-15-35(20-26(24)27)30(37)38-22-23-6-2-1-3-7-23/h1-10,12-14H,11,15-22H2
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n/an/a 12.4n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389790
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-2-methyl-4-[2-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1cnc(C)nc1
Show InChI InChI=1S/C27H30N8O/c1-19-15-33(11-12-35(19)26(36)17-34-18-31-24-6-4-9-28-27(24)34)25-7-3-5-21-8-10-32(16-23(21)25)22-13-29-20(2)30-14-22/h3-7,9,13-14,18-19H,8,10-12,15-17H2,1-2H3/t19-/m1/s1
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n/an/a 12.5n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389726
PNG
(2-(5-Methyl-pyrazol-1-yl)-1-{(R)-2-methyl-4-[5-tri...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nccc1C)c1ccc(c2CCN(Cc12)c1nc(cs1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C25H26F6N6OS/c1-15-5-7-32-37(15)13-22(38)36-10-9-34(11-16(36)2)20-4-3-19(24(26,27)28)17-6-8-35(12-18(17)20)23-33-21(14-39-23)25(29,30)31/h3-5,7,14,16H,6,8-13H2,1-2H3/t16-/m1/s1
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n/an/a 12.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389699
PNG
(US9951063, 18)
Show SMILES COc1cccc(c1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1cnc2cccnc12
Show InChI InChI=1S/C30H31F3N6O2/c1-20-16-37(13-14-39(20)28(40)18-38-19-35-26-7-4-11-34-29(26)38)27-9-8-25(30(31,32)33)23-10-12-36(17-24(23)27)21-5-3-6-22(15-21)41-2/h3-9,11,15,19-20H,10,12-14,16-18H2,1-2H3/t20-/m1/s1
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n/an/a 13n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389796
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-2-methyl-4-[2-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C31H31N7OS/c1-22-18-35(15-16-38(22)29(39)20-37-21-34-26-10-6-13-32-30(26)37)27-11-5-9-23-12-14-36(19-25(23)27)31-33-17-28(40-31)24-7-3-2-4-8-24/h2-11,13,17,21-22H,12,14-16,18-20H2,1H3/t22-/m1/s1
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n/an/a 13.3n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389690
PNG
(US9951063, 9)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1nc2ccc(C)cc2s1)C(F)(F)F
Show InChI InChI=1S/C30H33F3N6OS/c1-18-5-7-25-27(13-18)41-29(34-25)37-10-9-22-23(16-37)26(8-6-24(22)30(31,32)33)36-11-12-38(21(4)15-36)28(40)17-39-20(3)14-19(2)35-39/h5-8,13-14,21H,9-12,15-17H2,1-4H3/t21-/m1/s1
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n/an/a 13.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389711
PNG
(US9951063, 30)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN(CC1)C(=O)Cn1nc(C)nc1C
Show InChI InChI=1S/C26H31F3N8O2/c1-4-39-25-30-13-19(14-31-25)36-8-7-20-21(15-36)23(6-5-22(20)26(27,28)29)34-9-11-35(12-10-34)24(38)16-37-18(3)32-17(2)33-37/h5-6,13-14H,4,7-12,15-16H2,1-3H3
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n/an/a 13.8n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389782
PNG
(US9951063, 101)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ccccc1
Show InChI InChI=1S/C28H30N6O/c1-21-17-32(15-16-34(21)27(35)19-33-20-30-25-10-6-13-29-28(25)33)26-11-5-7-22-12-14-31(18-24(22)26)23-8-3-2-4-9-23/h2-11,13,20-21H,12,14-19H2,1H3/t21-/m1/s1
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n/an/a 14.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389797
PNG
(1-{(R)-4-[2-(4,5-Dimethyl-thiazol-2-yl)-1,2,3,4-te...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1nc(C)c(C)s1
Show InChI InChI=1S/C27H31N7OS/c1-18-14-31(12-13-34(18)25(35)16-33-17-29-23-7-5-10-28-26(23)33)24-8-4-6-21-9-11-32(15-22(21)24)27-30-19(2)20(3)36-27/h4-8,10,17-18H,9,11-16H2,1-3H3/t18-/m1/s1
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n/an/a 15.1n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389684
PNG
(US9951063, 3)
Show SMILES CCc1csc(n1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1nc(C)cc1C
Show InChI InChI=1S/C27H33F3N6OS/c1-5-20-16-38-26(31-20)34-9-8-21-22(14-34)24(7-6-23(21)27(28,29)30)33-10-11-35(19(4)13-33)25(37)15-36-18(3)12-17(2)32-36/h6-7,12,16,19H,5,8-11,13-15H2,1-4H3/t19-/m1/s1
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n/an/a 15.1n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389827
PNG
(US9951063, 146)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1ccc(C#N)c2CCN(Cc12)C(=O)Oc1ccccc1
Show InChI InChI=1S/C30H29N7O3/c1-21-17-34(14-15-37(21)28(38)19-36-20-33-26-8-5-12-32-29(26)36)27-10-9-22(16-31)24-11-13-35(18-25(24)27)30(39)40-23-6-3-2-4-7-23/h2-10,12,20-21H,11,13-15,17-19H2,1H3/t21-/m1/s1
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n/an/a 15.6n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389719
PNG
(US9951063, 38)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1ccc(c2CCN(Cc12)c1nc2ccc(F)cc2s1)C(F)(F)F
Show InChI InChI=1S/C28H29F4N7OS/c1-16-13-36(10-11-38(16)26(40)15-39-18(3)33-17(2)35-39)24-7-5-22(28(30,31)32)20-8-9-37(14-21(20)24)27-34-23-6-4-19(29)12-25(23)41-27/h4-7,12,16H,8-11,13-15H2,1-3H3/t16-/m1/s1
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n/an/a 15.8n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389715
PNG
(US9951063, 34)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@@H](C)C1)C(=O)Cn1cnc2cccnc12
Show InChI InChI=1S/C29H31F3N8O2/c1-3-42-28-34-13-20(14-35-28)37-10-8-21-22(16-37)25(7-6-23(21)29(30,31)32)38-11-12-40(19(2)15-38)26(41)17-39-18-36-24-5-4-9-33-27(24)39/h4-7,9,13-14,18-19H,3,8,10-12,15-17H2,1-2H3/t19-/m0/s1
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n/an/a 16.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389739
PNG
(US9951063, 58)
Show SMILES CCc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1nc(C)nc1C
Show InChI InChI=1S/C27H33F3N8O/c1-5-25-31-12-20(13-32-25)35-9-8-21-22(15-35)24(7-6-23(21)27(28,29)30)36-10-11-37(17(2)14-36)26(39)16-38-19(4)33-18(3)34-38/h6-7,12-13,17H,5,8-11,14-16H2,1-4H3/t17-/m1/s1
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n/an/a 16.9n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389756
PNG
(US9951063, 75)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C29H28Cl2N6O2/c1-19-15-34(12-13-37(19)27(38)17-36-18-33-25-5-3-10-32-28(25)36)26-6-2-4-20-9-11-35(16-22(20)26)29(39)21-7-8-23(30)24(31)14-21/h2-8,10,14,18-19H,9,11-13,15-17H2,1H3/t19-/m1/s1
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n/an/a 17n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389704
PNG
(US9951063, 23)
Show SMILES COc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1nc(C)nc1C
Show InChI InChI=1S/C26H31F3N8O2/c1-16-13-35(9-10-36(16)24(38)15-37-18(3)32-17(2)33-37)23-6-5-22(26(27,28)29)20-7-8-34(14-21(20)23)19-11-30-25(39-4)31-12-19/h5-6,11-12,16H,7-10,13-15H2,1-4H3/t16-/m1/s1
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n/an/a 17.1n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389687
PNG
(US9951063, 6)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1ncc(Cl)s1)C(F)(F)F
Show InChI InChI=1S/C25H28ClF3N6OS/c1-15-10-16(2)35(31-15)14-23(36)34-9-8-32(12-17(34)3)21-5-4-20(25(27,28)29)18-6-7-33(13-19(18)21)24-30-11-22(26)37-24/h4-5,10-11,17H,6-9,12-14H2,1-3H3/t17-/m1/s1
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n/an/a 18.1n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389786
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-4-[2-(4-methox...)
Show SMILES COc1ccc(cc1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C29H32N6O2/c1-21-17-33(15-16-35(21)28(36)19-34-20-31-26-6-4-13-30-29(26)34)27-7-3-5-22-12-14-32(18-25(22)27)23-8-10-24(37-2)11-9-23/h3-11,13,20-21H,12,14-19H2,1-2H3/t21-/m1/s1
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n/an/a 20.3n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389685
PNG
(US9951063, 4)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1nc(cs1)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C29H37F3N6OS/c1-18-13-19(2)38(34-18)16-26(39)37-12-11-35(14-20(37)3)24-8-7-23(29(30,31)32)21-9-10-36(15-22(21)24)27-33-25(17-40-27)28(4,5)6/h7-8,13,17,20H,9-12,14-16H2,1-6H3/t20-/m1/s1
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n/an/a 20.6n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389784
PNG
(US9951063, 103)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ccc(cn1)C(F)(F)F
Show InChI InChI=1S/C28H28F3N7O/c1-19-15-35(12-13-38(19)26(39)17-37-18-34-23-5-3-10-32-27(23)37)24-6-2-4-20-9-11-36(16-22(20)24)25-8-7-21(14-33-25)28(29,30)31/h2-8,10,14,18-19H,9,11-13,15-17H2,1H3/t19-/m1/s1
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n/an/a 20.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389820
PNG
(US9951063, 139)
Show SMILES Cn1c2ccccc2n(CC(=O)N2CCN(CC2)c2cccc3CCN(Cc23)C(=O)OCc2ccccc2)c1=O
Show InChI InChI=1S/C31H33N5O4/c1-32-27-11-5-6-12-28(27)36(30(32)38)21-29(37)34-18-16-33(17-19-34)26-13-7-10-24-14-15-35(20-25(24)26)31(39)40-22-23-8-3-2-4-9-23/h2-13H,14-22H2,1H3
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n/an/a 21.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389750
PNG
(US9951063, 69)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)C1CCCC1
Show InChI InChI=1S/C28H34N6O2/c1-20-16-31(14-15-34(20)26(35)18-33-19-30-24-9-5-12-29-27(24)33)25-10-4-8-21-11-13-32(17-23(21)25)28(36)22-6-2-3-7-22/h4-5,8-10,12,19-20,22H,2-3,6-7,11,13-18H2,1H3/t20-/m1/s1
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n/an/a 21.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389706
PNG
(US9951063, 25)
Show SMILES COc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1cccn1
Show InChI InChI=1S/C25H28F3N7O2/c1-17-14-33(10-11-35(17)23(36)16-34-8-3-7-31-34)22-5-4-21(25(26,27)28)19-6-9-32(15-20(19)22)18-12-29-24(37-2)30-13-18/h3-5,7-8,12-13,17H,6,9-11,14-16H2,1-2H3/t17-/m1/s1
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n/an/a 24n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389812
PNG
(US9951063, 131)
Show SMILES CCOc1ncc(cn1)N1CCc2c(F)ccc(N3CCN([C@H](C)C3)C(=O)Cn3nc(C)nc3C)c2C1
Show InChI InChI=1S/C26H33FN8O2/c1-5-37-26-28-12-20(13-29-26)32-9-8-21-22(15-32)24(7-6-23(21)27)33-10-11-34(17(2)14-33)25(36)16-35-19(4)30-18(3)31-35/h6-7,12-13,17H,5,8-11,14-16H2,1-4H3/t17-/m1/s1
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n/an/a 24.3n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389777
PNG
(US9951063, 96)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C29H29F3N6O/c1-20-16-36(14-15-38(20)27(39)18-37-19-34-25-5-3-12-33-28(25)37)26-6-2-4-21-11-13-35(17-24(21)26)23-9-7-22(8-10-23)29(30,31)32/h2-10,12,19-20H,11,13-18H2,1H3/t20-/m1/s1
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n/an/a 25.5n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389826
PNG
(US9951063, 145)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1ccc(c2CCN(Cc12)C(=O)OCc1ccccc1)C(F)(F)F
Show InChI InChI=1S/C31H31F3N6O3/c1-21-16-37(14-15-40(21)28(41)18-39-20-36-26-8-5-12-35-29(26)39)27-10-9-25(31(32,33)34)23-11-13-38(17-24(23)27)30(42)43-19-22-6-3-2-4-7-22/h2-10,12,20-21H,11,13-19H2,1H3/t21-/m1/s1
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n/an/a 25.6n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389738
PNG
(US9951063, 57)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1nc2ccccc2s1)C(F)(F)F
Show InChI InChI=1S/C29H31F3N6OS/c1-18-14-19(2)38(34-18)17-27(39)37-13-12-35(15-20(37)3)25-9-8-23(29(30,31)32)21-10-11-36(16-22(21)25)28-33-24-6-4-5-7-26(24)40-28/h4-9,14,20H,10-13,15-17H2,1-3H3/t20-/m1/s1
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n/an/a 26.5n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389695
PNG
(US9951063, 14)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1ncc(Br)cn1)C(F)(F)F
Show InChI InChI=1S/C26H29BrF3N7O/c1-16-10-17(2)37(33-16)15-24(38)36-9-8-34(13-18(36)3)23-5-4-22(26(28,29)30)20-6-7-35(14-21(20)23)25-31-11-19(27)12-32-25/h4-5,10-12,18H,6-9,13-15H2,1-3H3/t18-/m1/s1
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n/an/a 27.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389803
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-4-[2-(2-methox...)
Show SMILES COc1nccc(n1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C27H30N8O2/c1-19-15-32(13-14-35(19)25(36)17-34-18-30-22-6-4-10-28-26(22)34)23-7-3-5-20-9-12-33(16-21(20)23)24-8-11-29-27(31-24)37-2/h3-8,10-11,18-19H,9,12-17H2,1-2H3/t19-/m1/s1
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n/an/a 27.9n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389783
PNG
(US9951063, 102)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ncccn1
Show InChI InChI=1S/C26H28N8O/c1-19-15-31(13-14-34(19)24(35)17-33-18-30-22-6-3-9-27-25(22)33)23-7-2-5-20-8-12-32(16-21(20)23)26-28-10-4-11-29-26/h2-7,9-11,18-19H,8,12-17H2,1H3/t19-/m1/s1
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n/an/a 29.1n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389688
PNG
(US9951063, 7)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)cc1C)c1ccc(c2CCN(Cc12)c1nc(cs1)C#N)C(F)(F)F
Show InChI InChI=1S/C26H28F3N7OS/c1-16-10-17(2)36(32-16)14-24(37)35-9-8-33(12-18(35)3)23-5-4-22(26(27,28)29)20-6-7-34(13-21(20)23)25-31-19(11-30)15-38-25/h4-5,10,15,18H,6-9,12-14H2,1-3H3/t18-/m1/s1
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n/an/a 29.2n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389702
PNG
(US9951063, 21)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1ccc(c2CCN(Cc12)c1ccc(Cl)cc1)C(F)(F)F
Show InChI InChI=1S/C29H28ClF3N6O/c1-19-15-37(13-14-39(19)27(40)17-38-18-35-25-3-2-11-34-28(25)38)26-9-8-24(29(31,32)33)22-10-12-36(16-23(22)26)21-6-4-20(30)5-7-21/h2-9,11,18-19H,10,12-17H2,1H3/t19-/m1/s1
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n/an/a 29.9n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389710
PNG
(US9951063, 29)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN(CC1)C(=O)Cn1nc(C)cc1C
Show InChI InChI=1S/C27H32F3N7O2/c1-4-39-26-31-14-20(15-32-26)36-8-7-21-22(16-36)24(6-5-23(21)27(28,29)30)34-9-11-35(12-10-34)25(38)17-37-19(3)13-18(2)33-37/h5-6,13-15H,4,7-12,16-17H2,1-3H3
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n/an/a 30.5n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389716
PNG
(US9951063, 35)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@@H](C)C1)C(=O)Cn1nc(C)cc1C
Show InChI InChI=1S/C28H34F3N7O2/c1-5-40-27-32-13-21(14-33-27)35-9-8-22-23(16-35)25(7-6-24(22)28(29,30)31)36-10-11-37(20(4)15-36)26(39)17-38-19(3)12-18(2)34-38/h6-7,12-14,20H,5,8-11,15-17H2,1-4H3/t20-/m0/s1
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n/an/a 30.8n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389718
PNG
(US9951063, 37)
Show SMILES CCOc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@@H](C)C1)C(=O)CN1CCc2cccnc12
Show InChI InChI=1S/C30H34F3N7O2/c1-3-42-29-35-15-22(16-36-29)37-12-9-23-24(18-37)26(7-6-25(23)30(31,32)33)38-13-14-40(20(2)17-38)27(41)19-39-11-8-21-5-4-10-34-28(21)39/h4-7,10,15-16,20H,3,8-9,11-14,17-19H2,1-2H3/t20-/m0/s1
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US Patent
n/an/a 30.9n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389789
PNG
(2-Imidazo[4,5-b]pyridin-3-yl-1-{(R)-2-methyl-4-[2-...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1ncc(C)cn1
Show InChI InChI=1S/C27H30N8O/c1-19-13-29-27(30-14-19)33-10-8-21-5-3-7-24(22(21)16-33)32-11-12-35(20(2)15-32)25(36)17-34-18-31-23-6-4-9-28-26(23)34/h3-7,9,13-14,18,20H,8,10-12,15-17H2,1-2H3/t20-/m1/s1
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n/an/a 32.6n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389808
PNG
(US9951063, 127)
Show SMILES CCOc1ncc(cn1)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3nc(C)nc3C)c2C1
Show InChI InChI=1S/C26H34N8O2/c1-5-36-26-27-13-22(14-28-26)31-10-9-21-7-6-8-24(23(21)16-31)32-11-12-33(18(2)15-32)25(35)17-34-20(4)29-19(3)30-34/h6-8,13-14,18H,5,9-12,15-17H2,1-4H3/t18-/m1/s1
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n/an/a 33.1n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389817
PNG
(US9951063, 136)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1cccc2CCN(Cc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C28H34N6O3/c1-20-16-31(14-15-33(20)27(35)18-34-22(3)29-21(2)30-34)26-11-7-10-24-12-13-32(17-25(24)26)28(36)37-19-23-8-5-4-6-9-23/h4-11,20H,12-19H2,1-3H3/t20-/m1/s1
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n/an/a 33.2n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389805
PNG
(US9951063, 124)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)c1nc(cs1)-c1ccccc1
Show InChI InChI=1S/C31H31N7OS/c1-22-17-35(15-16-38(22)29(39)19-37-21-33-26-10-6-13-32-30(26)37)28-11-5-9-23-12-14-36(18-25(23)28)31-34-27(20-40-31)24-7-3-2-4-8-24/h2-11,13,20-22H,12,14-19H2,1H3/t22-/m1/s1
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n/an/a 34.4n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389724
PNG
(1-{(R)-2-Methyl-4-[5-trifluoromethyl-2-(4-trifluor...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1ncc2cccnc12)c1ccc(c2CCN(Cc12)c1nc(cs1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C27H25F6N7OS/c1-16-12-37(9-10-39(16)23(41)14-40-24-17(11-35-40)3-2-7-34-24)21-5-4-20(26(28,29)30)18-6-8-38(13-19(18)21)25-36-22(15-42-25)27(31,32)33/h2-5,7,11,15-16H,6,8-10,12-14H2,1H3/t16-/m1/s1
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n/an/a 38.6n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389755
PNG
(US9951063, 74)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C29H29ClN6O2/c1-20-16-33(14-15-36(20)27(37)18-35-19-32-25-5-3-12-31-28(25)35)26-6-2-4-21-11-13-34(17-24(21)26)29(38)22-7-9-23(30)10-8-22/h2-10,12,19-20H,11,13-18H2,1H3/t20-/m1/s1
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n/an/a 46.6n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389806
PNG
(US9951063, 125)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1cccc2CCN(Cc12)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H29F3N8O/c1-16-13-34(9-10-35(16)23(37)15-36-18(3)31-17(2)32-36)22-6-4-5-19-7-8-33(14-21(19)22)20-11-29-24(30-12-20)25(26,27)28/h4-6,11-12,16H,7-10,13-15H2,1-3H3/t16-/m1/s1
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n/an/a 47.4n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389721
PNG
(1-{(R)-4-[2-(6-Fluoro-benzothiazol-2-yl)-5-trifluo...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1ccc(C)n1)c1ccc(c2CCN(Cc12)c1nc2ccc(F)cc2s1)C(F)(F)F
Show InChI InChI=1S/C28H28F4N6OS/c1-17-7-10-37(34-17)16-26(39)38-12-11-35(14-18(38)2)24-6-4-22(28(30,31)32)20-8-9-36(15-21(20)24)27-33-23-5-3-19(29)13-25(23)40-27/h3-7,10,13,18H,8-9,11-12,14-16H2,1-2H3/t18-/m1/s1
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n/an/a 49n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389821
PNG
(US9951063, 140)
Show SMILES Cn1c2ccccc2n(CC(=O)N2CCN(CC2)c2cccc3CCN(Cc23)C(=O)c2ccccc2)c1=O
Show InChI InChI=1S/C30H31N5O3/c1-31-26-11-5-6-12-27(26)35(30(31)38)21-28(36)33-18-16-32(17-19-33)25-13-7-10-22-14-15-34(20-24(22)25)29(37)23-8-3-2-4-9-23/h2-13H,14-21H2,1H3
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n/an/a 51.2n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389722
PNG
(1-{(R)-4-[2-(6-Fluoro-benzothiazol-2-yl)-5-trifluo...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nccc1C)c1ccc(c2CCN(Cc12)c1nc2ccc(F)cc2s1)C(F)(F)F
Show InChI InChI=1S/C28H28F4N6OS/c1-17-7-9-33-38(17)16-26(39)37-12-11-35(14-18(37)2)24-6-4-22(28(30,31)32)20-8-10-36(15-21(20)24)27-34-23-5-3-19(29)13-25(23)40-27/h3-7,9,13,18H,8,10-12,14-16H2,1-2H3/t18-/m1/s1
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n/an/a 51.4n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389815
PNG
(US9951063, 134)
Show SMILES CCOc1ncc(cn1)N1CCc2cc(cc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1)C(F)(F)F
Show InChI InChI=1S/C29H31F3N8O2/c1-3-42-28-34-13-22(14-35-28)37-8-6-20-11-21(29(30,31)32)12-25(23(20)16-37)38-9-10-40(19(2)15-38)26(41)17-39-18-36-24-5-4-7-33-27(24)39/h4-5,7,11-14,18-19H,3,6,8-10,15-17H2,1-2H3/t19-/m1/s1
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n/an/a 52.1n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389751
PNG
(US9951063, 70)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)C1CCCCC1
Show InChI InChI=1S/C29H36N6O2/c1-21-17-32(15-16-35(21)27(36)19-34-20-31-25-10-6-13-30-28(25)34)26-11-5-9-22-12-14-33(18-24(22)26)29(37)23-7-3-2-4-8-23/h5-6,9-11,13,20-21,23H,2-4,7-8,12,14-19H2,1H3/t21-/m1/s1
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n/an/a 55.5n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389813
PNG
(US9951063, 132)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1nc(C)nc1C)c1ccc(F)c2CCN(Cc12)c1cnc(nc1)C(F)(F)F
Show InChI InChI=1S/C25H28F4N8O/c1-15-12-35(8-9-36(15)23(38)14-37-17(3)32-16(2)33-37)22-5-4-21(26)19-6-7-34(13-20(19)22)18-10-30-24(31-11-18)25(27,28)29/h4-5,10-11,15H,6-9,12-14H2,1-3H3/t15-/m1/s1
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n/an/a 58.9n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389775
PNG
(US9951063, 94)
Show SMILES COc1ccccc1N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C29H32N6O2/c1-21-17-33(15-16-35(21)28(36)19-34-20-31-24-8-6-13-30-29(24)34)25-10-5-7-22-12-14-32(18-23(22)25)26-9-3-4-11-27(26)37-2/h3-11,13,20-21H,12,14-19H2,1-2H3/t21-/m1/s1
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n/an/a 61.9n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389762
PNG
(US9951063, 81)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)COc1ccccc1
Show InChI InChI=1S/C30H32N6O3/c1-22-17-33(15-16-36(22)28(37)19-35-21-32-26-10-6-13-31-30(26)35)27-11-5-7-23-12-14-34(18-25(23)27)29(38)20-39-24-8-3-2-4-9-24/h2-11,13,21-22H,12,14-20H2,1H3/t22-/m1/s1
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n/an/a 65.1n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389823
PNG
(US9951063, 142)
Show SMILES O=C(Cn1cnc2cccnc12)N1CCN(CC1)c1cccc2CCN(Cc12)S(=O)(=O)Cc1ccccc1
Show InChI InChI=1S/C28H30N6O3S/c35-27(19-33-21-30-25-9-5-12-29-28(25)33)32-16-14-31(15-17-32)26-10-4-8-23-11-13-34(18-24(23)26)38(36,37)20-22-6-2-1-3-7-22/h1-10,12,21H,11,13-20H2
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n/an/a 65.4n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389720
PNG
(1-{(R)-4-[2-(6-Fluoro-benzothiazol-2-yl)-5-trifluo...)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1ncc2cccnc12)c1ccc(c2CCN(Cc12)c1nc2ccc(F)cc2s1)C(F)(F)F
Show InChI InChI=1S/C30H27F4N7OS/c1-18-15-38(11-12-40(18)27(42)17-41-28-19(14-36-41)3-2-9-35-28)25-7-5-23(30(32,33)34)21-8-10-39(16-22(21)25)29-37-24-6-4-20(31)13-26(24)43-29/h2-7,9,13-14,18H,8,10-12,15-17H2,1H3/t18-/m1/s1
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n/an/a 73.5n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389752
PNG
(US9951063, 71)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)[C@@H]1CCCc2ccccc12
Show InChI InChI=1S/C33H36N6O2/c1-23-19-36(17-18-39(23)31(40)21-38-22-35-29-12-6-15-34-32(29)38)30-13-5-9-25-14-16-37(20-28(25)30)33(41)27-11-4-8-24-7-2-3-10-26(24)27/h2-3,5-7,9-10,12-13,15,22-23,27H,4,8,11,14,16-21H2,1H3/t23-,27-/m1/s1
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n/an/a 80.2n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389757
PNG
(US9951063, 76)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)c1cccc(c1)N(C)C
Show InChI InChI=1S/C31H35N7O2/c1-22-18-35(15-16-38(22)29(39)20-37-21-33-27-10-6-13-32-30(27)37)28-11-5-7-23-12-14-36(19-26(23)28)31(40)24-8-4-9-25(17-24)34(2)3/h4-11,13,17,21-22H,12,14-16,18-20H2,1-3H3/t22-/m1/s1
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n/an/a 82.4n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389825
PNG
(US9951063, 144)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1ccc(Br)c2CCN(Cc12)C(=O)OCc1ccccc1
Show InChI InChI=1S/C30H31BrN6O3/c1-21-16-34(14-15-37(21)28(38)18-36-20-33-26-8-5-12-32-29(26)36)27-10-9-25(31)23-11-13-35(17-24(23)27)30(39)40-19-22-6-3-2-4-7-22/h2-10,12,20-21H,11,13-19H2,1H3/t21-/m1/s1
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n/an/a 85.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389763
PNG
(US9951063, 82)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)CCc1ccc(Cl)cc1
Show InChI InChI=1S/C31H33ClN6O2/c1-22-18-35(16-17-38(22)30(40)20-37-21-34-27-5-3-14-33-31(27)37)28-6-2-4-24-13-15-36(19-26(24)28)29(39)12-9-23-7-10-25(32)11-8-23/h2-8,10-11,14,21-22H,9,12-13,15-20H2,1H3/t22-/m1/s1
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n/an/a 88.1n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389753
PNG
(US9951063, 72)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)[C]1(=O)=CC=CC=C1
Show InChI InChI=1S/C28H30N6O2/c1-21-17-31(15-16-34(21)26(35)19-32-20-30-24-8-6-13-29-27(24)32)25-9-5-7-22-10-14-33(18-23(22)25)28(36)11-3-2-4-12-28/h2-9,11-13,20-21H,10,14-19H2,1H3/t21-/m1/s1
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n/an/a 92.2n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389758
PNG
(US9951063, 77)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O2/c1-20-16-36(14-15-39(20)27(40)18-38-19-35-25-5-3-12-34-28(25)38)26-6-2-4-21-11-13-37(17-24(21)26)29(41)22-7-9-23(10-8-22)30(31,32)33/h2-10,12,19-20H,11,13-18H2,1H3/t20-/m1/s1
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n/an/a 92.3n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389707
PNG
(US9951063, 26)
Show SMILES COc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)Cn1nccn1
Show InChI InChI=1S/C24H27F3N8O2/c1-16-13-33(9-10-34(16)22(36)15-35-30-6-7-31-35)21-4-3-20(24(25,26)27)18-5-8-32(14-19(18)21)17-11-28-23(37-2)29-12-17/h3-4,6-7,11-12,16H,5,8-10,13-15H2,1-2H3/t16-/m1/s1
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n/an/a 98.5n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389765
PNG
(US9951063, 84)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)CCc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C31H32Cl2N6O2/c1-21-17-36(14-15-39(21)30(41)19-38-20-35-27-5-3-12-34-31(27)38)28-6-2-4-23-11-13-37(18-24(23)28)29(40)10-8-22-7-9-25(32)26(33)16-22/h2-7,9,12,16,20-21H,8,10-11,13-15,17-19H2,1H3/t21-/m1/s1
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n/an/a 99.7n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389754
PNG
(US9951063, 73)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)c1ccc(C)cc1
Show InChI InChI=1S/C30H32N6O2/c1-21-8-10-24(11-9-21)30(38)34-14-12-23-5-3-7-27(25(23)18-34)33-15-16-36(22(2)17-33)28(37)19-35-20-32-26-6-4-13-31-29(26)35/h3-11,13,20,22H,12,14-19H2,1-2H3/t22-/m1/s1
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n/an/a 111n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389816
PNG
(US9951063, 135)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cccn1)c1cccc2CCN(Cc12)C(=O)Oc1ccccc1
Show InChI InChI=1S/C26H29N5O3/c1-20-17-28(15-16-31(20)25(32)19-30-13-6-12-27-30)24-10-5-7-21-11-14-29(18-23(21)24)26(33)34-22-8-3-2-4-9-22/h2-10,12-13,20H,11,14-19H2,1H3/t20-/m1/s1
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n/an/a 116n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389743
PNG
(US9951063, 62)
Show SMILES COc1ccc(cc1)C(=O)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C30H32N6O3/c1-21-17-33(15-16-36(21)28(37)19-35-20-32-26-6-4-13-31-29(26)35)27-7-3-5-22-12-14-34(18-25(22)27)30(38)23-8-10-24(39-2)11-9-23/h3-11,13,20-21H,12,14-19H2,1-2H3/t21-/m1/s1
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n/an/a 121n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389745
PNG
(US9951063, 64)
Show SMILES COc1ccc(CCC(=O)N2CCc3cccc(N4CCN([C@H](C)C4)C(=O)Cn4cnc5cccnc45)c3C2)cc1
Show InChI InChI=1S/C32H36N6O3/c1-23-19-35(17-18-38(23)31(40)21-37-22-34-28-6-4-15-33-32(28)37)29-7-3-5-25-14-16-36(20-27(25)29)30(39)13-10-24-8-11-26(41-2)12-9-24/h3-9,11-12,15,22-23H,10,13-14,16-21H2,1-2H3/t23-/m1/s1
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n/an/a 188n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389822
PNG
(US9951063, 141)
Show SMILES Cn1c2ccccc2n(CC(=O)N2CCN(CC2)c2cccc3CCNC(C(=O)Cc4ccccc4)c23)c1=O
Show InChI InChI=1S/C31H33N5O3/c1-33-24-11-5-6-12-25(24)36(31(33)39)21-28(38)35-18-16-34(17-19-35)26-13-7-10-23-14-15-32-30(29(23)26)27(37)20-22-8-3-2-4-9-22/h2-13,30,32H,14-21H2,1H3
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n/an/a 190n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389761
PNG
(US9951063, 80)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)C1(CC1)c1ccccc1
Show InChI InChI=1S/C32H34N6O2/c1-23-19-35(17-18-38(23)29(39)21-37-22-34-27-10-6-15-33-30(27)37)28-11-5-7-24-12-16-36(20-26(24)28)31(40)32(13-14-32)25-8-3-2-4-9-25/h2-11,15,22-23H,12-14,16-21H2,1H3/t23-/m1/s1
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n/an/a 199n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389759
PNG
(US9951063, 78)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCNC(C(=O)Cc3ccccc3)c12
Show InChI InChI=1S/C30H32N6O2/c1-21-18-34(15-16-36(21)27(38)19-35-20-33-24-10-6-13-32-30(24)35)25-11-5-9-23-12-14-31-29(28(23)25)26(37)17-22-7-3-2-4-8-22/h2-11,13,20-21,29,31H,12,14-19H2,1H3/t21-,29?/m1/s1
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n/an/a 216n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389742
PNG
(US9951063, 61)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)C1CC1
Show InChI InChI=1S/C26H30N6O2/c1-18-14-29(12-13-32(18)24(33)16-31-17-28-22-5-3-10-27-25(22)31)23-6-2-4-19-9-11-30(15-21(19)23)26(34)20-7-8-20/h2-6,10,17-18,20H,7-9,11-16H2,1H3/t18-/m1/s1
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n/an/a 223n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389747
PNG
(US9951063, 66)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)Cn1ccc2ccccc12
Show InChI InChI=1S/C32H33N7O2/c1-23-18-36(16-17-39(23)31(41)21-38-22-34-27-8-5-13-33-32(27)38)29-10-4-7-24-11-15-37(19-26(24)29)30(40)20-35-14-12-25-6-2-3-9-28(25)35/h2-10,12-14,22-23H,11,15-21H2,1H3/t23-/m1/s1
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n/an/a 304n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389764
PNG
(US9951063, 83)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)CCc1ccccc1
Show InChI InChI=1S/C31H34N6O2/c1-23-19-34(17-18-37(23)30(39)21-36-22-33-27-10-6-15-32-31(27)36)28-11-5-9-25-14-16-35(20-26(25)28)29(38)13-12-24-7-3-2-4-8-24/h2-11,15,22-23H,12-14,16-21H2,1H3/t23-/m1/s1
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n/an/a 450n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389824
PNG
(US9951063, 143)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc3ccc(Cl)cc3)Cc12
Show InChI InChI=1S/C29H31ClN6O/c1-21-16-34(14-15-36(21)28(37)19-35-20-32-26-5-3-12-31-29(26)35)27-6-2-4-23-11-13-33(18-25(23)27)17-22-7-9-24(30)10-8-22/h2-10,12,20-21H,11,13-19H2,1H3/t21-/m1/s1
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n/an/a 465n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389746
PNG
(US9951063, 65)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)c1cocn1
Show InChI InChI=1S/C26H27N7O3/c1-18-12-30(10-11-33(18)24(34)14-32-16-28-21-5-3-8-27-25(21)32)23-6-2-4-19-7-9-31(13-20(19)23)26(35)22-15-36-17-29-22/h2-6,8,15-18H,7,9-14H2,1H3/t18-/m1/s1
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n/an/a 483n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389760
PNG
(US9951063, 79)
Show SMILES C[C@@H](C(=O)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1)c1ccccc1
Show InChI InChI=1S/C31H34N6O2/c1-22-18-34(16-17-37(22)29(38)20-36-21-33-27-11-7-14-32-30(27)36)28-12-6-10-25-13-15-35(19-26(25)28)31(39)23(2)24-8-4-3-5-9-24/h3-12,14,21-23H,13,15-20H2,1-2H3/t22-,23-/m1/s1
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n/an/a 570n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389749
PNG
(US9951063, 68)
Show SMILES COCC(=O)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C25H30N6O3/c1-18-13-28(22-7-3-5-19-8-10-29(14-20(19)22)24(33)16-34-2)11-12-31(18)23(32)15-30-17-27-21-6-4-9-26-25(21)30/h3-7,9,17-18H,8,10-16H2,1-2H3/t18-/m1/s1
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n/an/a 599n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389748
PNG
(US9951063, 67)
Show SMILES CC(C)C(=O)N1CCc2cccc(N3CCN([C@H](C)C3)C(=O)Cn3cnc4cccnc34)c2C1
Show InChI InChI=1S/C26H32N6O2/c1-18(2)26(34)30-11-9-20-6-4-8-23(21(20)15-30)29-12-13-32(19(3)14-29)24(33)16-31-17-28-22-7-5-10-27-25(22)31/h4-8,10,17-19H,9,11-16H2,1-3H3/t19-/m1/s1
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n/an/a 614n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389744
PNG
(US9951063, 63)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)Cc1cccnc1
Show InChI InChI=1S/C29H31N7O2/c1-21-17-33(13-14-36(21)28(38)19-35-20-32-25-7-4-11-31-29(25)35)26-8-2-6-23-9-12-34(18-24(23)26)27(37)15-22-5-3-10-30-16-22/h2-8,10-11,16,20-21H,9,12-15,17-19H2,1H3/t21-/m1/s1
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n/an/a 668n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389767
PNG
(US9951063, 86)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)Cn1cnc2ccccc12
Show InChI InChI=1S/C31H32N8O2/c1-22-16-35(14-15-39(22)30(41)19-38-21-34-26-8-5-12-32-31(26)38)27-10-4-6-23-11-13-36(17-24(23)27)29(40)18-37-20-33-25-7-2-3-9-28(25)37/h2-10,12,20-22H,11,13-19H2,1H3/t22-/m1/s1
UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/a 686n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389766
PNG
(US9951063, 85)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)c1ccc2ncccc2c1
Show InChI InChI=1S/C32H31N7O2/c1-22-18-36(15-16-39(22)30(40)20-38-21-35-28-7-4-13-34-31(28)38)29-8-2-5-23-11-14-37(19-26(23)29)32(41)25-9-10-27-24(17-25)6-3-12-33-27/h2-10,12-13,17,21-22H,11,14-16,18-20H2,1H3/t22-/m1/s1
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 866n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389708
PNG
(US9951063, 27)
Show SMILES COc1ncc(cn1)N1CCc2c(C1)c(ccc2C(F)(F)F)N1CCN([C@H](C)C1)C(=O)CCn1cccn1
Show InChI InChI=1S/C26H30F3N7O2/c1-18-16-34(12-13-36(18)24(37)7-11-35-9-3-8-32-35)23-5-4-22(26(27,28)29)20-6-10-33(17-21(20)23)19-14-30-25(38-2)31-15-19/h3-5,8-9,14-15,18H,6-7,10-13,16-17H2,1-2H3/t18-/m1/s1
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US Patent
n/an/a 908n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389770
PNG
(US9951063, 89)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)c1ccnn1C
Show InChI InChI=1S/C27H30N8O2/c1-19-15-32(13-14-35(19)25(36)17-34-18-29-22-6-4-10-28-26(22)34)23-7-3-5-20-9-12-33(16-21(20)23)27(37)24-8-11-30-31(24)2/h3-8,10-11,18-19H,9,12-17H2,1-2H3/t19-/m1/s1
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US Patent
n/an/a 955n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389769
PNG
(US9951063, 88)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)CN1CCOCC1
Show InChI InChI=1S/C28H35N7O3/c1-21-16-32(10-11-35(21)27(37)19-34-20-30-24-5-3-8-29-28(24)34)25-6-2-4-22-7-9-33(17-23(22)25)26(36)18-31-12-14-38-15-13-31/h2-6,8,20-21H,7,9-19H2,1H3/t21-/m1/s1
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 1.91E+3n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
chemokine (C-X-C motif) receptor 3


(Homo sapiens (Human))
BDBM389768
PNG
(US9951063, 87)
Show SMILES C[C@@H]1CN(CCN1C(=O)Cn1cnc2cccnc12)c1cccc2CCN(Cc12)C(=O)Cn1cccn1
Show InChI InChI=1S/C27H30N8O2/c1-20-15-31(13-14-35(20)26(37)17-33-19-29-23-6-3-9-28-27(23)33)24-7-2-5-21-8-12-32(16-22(21)24)25(36)18-34-11-4-10-30-34/h2-7,9-11,19-20H,8,12-18H2,1H3/t20-/m1/s1
UniProtKB/SwissProt

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UniChem
US Patent
n/an/a 5.42E+3n/an/an/an/an/an/a



IDORSIA PHARMACEUTICALS LTD

US Patent


Assay Description
The bioactivity of compounds is tested in a fluorometric imaging plate reader (FLIPR: Molecular Devices) using engineered CHO-K1 cells expressing the...


US Patent US9951063 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%