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Patent code US9951077

Compile Data Set for Download or QSAR
Found 118 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389996
PNG
(US9951077, 13)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CN(CCC1F)C(=O)C=C
Show InChI InChI=1/C26H24FN5O3/c1-2-22(33)31-13-12-20(27)21(15-31)32-14-19(23-24(32)26(34)30-29-25(23)28)16-8-10-18(11-9-16)35-17-6-4-3-5-7-17/h2-11,14,20-21H,1,12-13,15H2,(H2,28,29)(H,30,34)
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n/an/a<10n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390034
PNG
(4-amino-1-[[1-[(E)-4- (dimethylamino)but-2- enoyl]...)
Show SMILES CN(C)C\C=C\C(=O)N1CC(Cn2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c23)C1
Show InChI InChI=1S/C28H30N6O3/c1-32(2)14-6-9-24(35)33-15-19(16-33)17-34-18-23(25-26(34)28(36)31-30-27(25)29)20-10-12-22(13-11-20)37-21-7-4-3-5-8-21/h3-13,18-19H,14-17H2,1-2H3,(H2,29,30)(H,31,36)/b9-6+
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n/an/a<10n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390021
PNG
(4-amino-3-(4-phenoxyphenyl)-1- [(3R)-1-[(E)-4-pyrr...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)\C=C\CN1CCCC1
Show InChI InChI=1S/C31H34N6O3/c32-30-28-26(22-12-14-25(15-13-22)40-24-9-2-1-3-10-24)21-37(29(28)31(39)34-33-30)23-8-6-19-36(20-23)27(38)11-7-18-35-16-4-5-17-35/h1-3,7,9-15,21,23H,4-6,8,16-20H2,(H2,32,33)(H,34,39)/b11-7+/t23-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390039
PNG
(US9951077, 52)
Show SMILES COc1ccc(cc1)-c1cn(C2CCCN(C2)C(=O)\C=C\CN(C)C)c2c1c(N)n[nH]c2=O
Show InChI InChI=1/C24H30N6O3/c1-28(2)12-5-7-20(31)29-13-4-6-17(14-29)30-15-19(16-8-10-18(33-3)11-9-16)21-22(30)24(32)27-26-23(21)25/h5,7-11,15,17H,4,6,12-14H2,1-3H3,(H2,25,26)(H,27,32)/b7-5+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390056
PNG
(US9951077, 69)
Show SMILES COc1cc(ccc1Oc1cccc(Cl)c1)-c1cn(C2CCCN(C2)C(=O)\C=C\CN(C)C)c2c1c(N)n[nH]c2=O
Show InChI InChI=1/C30H33ClN6O4/c1-35(2)13-6-10-26(38)36-14-5-8-21(17-36)37-18-23(27-28(37)30(39)34-33-29(27)32)19-11-12-24(25(15-19)40-3)41-22-9-4-7-20(31)16-22/h4,6-7,9-12,15-16,18,21H,5,8,13-14,17H2,1-3H3,(H2,32,33)(H,34,39)/b10-6+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390066
PNG
(US9951077, 79)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3c(F)cccc3Cl)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H30ClFN6O3/c1-35(2)14-5-9-24(38)36-15-4-6-19(16-36)37-17-21(25-26(37)29(39)34-33-28(25)32)18-10-12-20(13-11-18)40-27-22(30)7-3-8-23(27)31/h3,5,7-13,17,19H,4,6,14-16H2,1-2H3,(H2,32,33)(H,34,39)/b9-5+/t19-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390069
PNG
(US9951077, 82)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1c(F)c(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H31FN6O3/c1-34(2)16-7-11-23(37)35-17-6-8-20(18-35)36-26-25(28(31)32-33-29(26)38)24(27(36)30)19-12-14-22(15-13-19)39-21-9-4-3-5-10-21/h3-5,7,9-15,20H,6,8,16-18H2,1-2H3,(H2,31,32)(H,33,38)/b11-7+/t20-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390075
PNG
(US9951077, 88)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C27H21N5O3/c1-2-23(33)29-18-7-6-8-19(15-18)32-16-22(24-25(32)27(34)31-30-26(24)28)17-11-13-21(14-12-17)35-20-9-4-3-5-10-20/h2-16H,1H2,(H2,28,30)(H,29,33)(H,31,34)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390014
PNG
(4-amino-1-[(3R)-1-[(E)-4- (cyclopropylamino)but-2-...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)\C=C\CNC1CC1
Show InChI InChI=1S/C30H32N6O3/c31-29-27-25(20-10-14-24(15-11-20)39-23-7-2-1-3-8-23)19-36(28(27)30(38)34-33-29)22-6-5-17-35(18-22)26(37)9-4-16-32-21-12-13-21/h1-4,7-11,14-15,19,21-22,32H,5-6,12-13,16-18H2,(H2,31,33)(H,34,38)/b9-4+/t22-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390041
PNG
(US9951077, 54)
Show SMILES COc1ccc(cc1Cl)-c1cn(C2CCCN(C2)C(=O)\C=C\CN(C)C)c2c1c(N)n[nH]c2=O
Show InChI InChI=1/C24H29ClN6O3/c1-29(2)10-5-7-20(32)30-11-4-6-16(13-30)31-14-17(15-8-9-19(34-3)18(25)12-15)21-22(31)24(33)28-27-23(21)26/h5,7-9,12,14,16H,4,6,10-11,13H2,1-3H3,(H2,26,27)(H,28,33)/b7-5+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390042
PNG
(US9951077, 55)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4F)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C26H24FN5O3/c1-2-22(33)31-13-5-6-17(14-31)32-15-19(23-24(32)26(34)30-29-25(23)28)16-9-11-18(12-10-16)35-21-8-4-3-7-20(21)27/h2-4,7-12,15,17H,1,5-6,13-14H2,(H2,28,29)(H,30,34)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390050
PNG
(US9951077, 63)
Show SMILES CN(C)C\C=C\C(=O)N1CCCC(C1)n1cc(-c2ccc(Oc3cccc(F)c3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1/C29H31FN6O3/c1-34(2)14-5-9-25(37)35-15-4-7-21(17-35)36-18-24(26-27(36)29(38)33-32-28(26)31)19-10-12-22(13-11-19)39-23-8-3-6-20(30)16-23/h3,5-6,8-13,16,18,21H,4,7,14-15,17H2,1-2H3,(H2,31,32)(H,33,38)/b9-5+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389997
PNG
(US9951077, 14)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CN(CC(F)(F)C1)C(=O)C=C
Show InChI InChI=1S/C26H23F2N5O3/c1-2-21(34)32-13-17(12-26(27,28)15-32)33-14-20(22-23(33)25(35)31-30-24(22)29)16-8-10-19(11-9-16)36-18-6-4-3-5-7-18/h2-11,14,17H,1,12-13,15H2,(H2,29,30)(H,31,35)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390018
PNG
(4-amino-1-[(3R)-1-[(E)-4- [cyclobutyl(methyl)amino...)
Show SMILES CN(C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12)C1CCC1
Show InChI InChI=1S/C32H36N6O3/c1-36(23-8-5-9-23)18-7-13-28(39)37-19-6-10-24(20-37)38-21-27(29-30(38)32(40)35-34-31(29)33)22-14-16-26(17-15-22)41-25-11-3-2-4-12-25/h2-4,7,11-17,21,23-24H,5-6,8-10,18-20H2,1H3,(H2,33,34)(H,35,40)/b13-7+/t24-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390040
PNG
(US9951077, 53)
Show SMILES COc1ccc(cc1Cl)-c1cn(C2CCCN(C2)C(=O)C=C)c2c1c(N)n[nH]c2=O
Show InChI InChI=1/C21H22ClN5O3/c1-3-17(28)26-8-4-5-13(10-26)27-11-14(12-6-7-16(30-2)15(22)9-12)18-19(27)21(29)25-24-20(18)23/h3,6-7,9,11,13H,1,4-5,8,10H2,2H3,(H2,23,24)(H,25,29)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390058
PNG
(US9951077, 71)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3Cl)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H31ClN6O3/c1-34(2)15-6-10-25(37)35-16-5-7-20(17-35)36-18-22(26-27(36)29(38)33-32-28(26)31)19-11-13-21(14-12-19)39-24-9-4-3-8-23(24)30/h3-4,6,8-14,18,20H,5,7,15-17H2,1-2H3,(H2,31,32)(H,33,38)/b10-6+/t20-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390062
PNG
(US9951077, 75)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)c(F)c2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H31FN6O3/c1-34(2)14-7-11-25(37)35-15-6-8-20(17-35)36-18-22(26-27(36)29(38)33-32-28(26)31)19-12-13-24(23(30)16-19)39-21-9-4-3-5-10-21/h3-5,7,9-13,16,18,20H,6,8,14-15,17H2,1-2H3,(H2,31,32)(H,33,38)/b11-7+/t20-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390064
PNG
(US9951077, 77)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2F)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H31FN6O3/c1-34(2)14-7-11-25(37)35-15-6-8-19(17-35)36-18-23(26-27(36)29(38)33-32-28(26)31)22-13-12-21(16-24(22)30)39-20-9-4-3-5-10-20/h3-5,7,9-13,16,18-19H,6,8,14-15,17H2,1-2H3,(H2,31,32)(H,33,38)/b11-7+/t19-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390065
PNG
(US9951077, 78)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4c(F)cccc4Cl)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H23ClFN5O3/c1-2-21(34)32-12-4-5-16(13-32)33-14-18(22-23(33)26(35)31-30-25(22)29)15-8-10-17(11-9-15)36-24-19(27)6-3-7-20(24)28/h2-3,6-11,14,16H,1,4-5,12-13H2,(H2,29,30)(H,31,35)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390099
PNG
(US9951077, 111)
Show SMILES CC#CC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C25H22N6O3/c1-2-6-20(32)30-14-13-17(15-30)31-23-21(24(26)27-28-25(23)33)22(29-31)16-9-11-19(12-10-16)34-18-7-4-3-5-8-18/h3-5,7-12,17H,13-15H2,1H3,(H2,26,27)(H,28,33)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389985
PNG
(4-amino-3-(4-phenoxyphenyl)-1-(1- prop-2-enoyl-3-p...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H23N5O3/c1-2-21(31)29-13-12-17(14-29)30-15-20(22-23(30)25(32)28-27-24(22)26)16-8-10-19(11-9-16)33-18-6-4-3-5-7-18/h2-11,15,17H,1,12-14H2,(H2,26,27)(H,28,32)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390054
PNG
(US9951077, 67)
Show SMILES CN(C)C\C=C\C(=O)N1CCCC(C1)n1cc(-c2ccc(Oc3cccc(Cl)c3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1/C29H31ClN6O3/c1-34(2)14-5-9-25(37)35-15-4-7-21(17-35)36-18-24(26-27(36)29(38)33-32-28(26)31)19-10-12-22(13-11-19)39-23-8-3-6-20(30)16-23/h3,5-6,8-13,16,18,21H,4,7,14-15,17H2,1-2H3,(H2,31,32)(H,33,38)/b9-5+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390074
PNG
(US9951077, 87)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4F)cc3)c12)[C@@H]1CCCN(C1)C#N
Show InChI InChI=1S/C24H21FN6O2/c25-19-5-1-2-6-20(19)33-17-9-7-15(8-10-17)18-13-31(16-4-3-11-30(12-16)14-26)22-21(18)23(27)28-29-24(22)32/h1-2,5-10,13,16H,3-4,11-12H2,(H2,27,28)(H,29,32)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390096
PNG
(US9951077, 108)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4F)cc3)c12)C1CCCN(C1)C#N
Show InChI InChI=1/C24H21FN6O2/c25-19-5-1-2-6-20(19)33-17-9-7-15(8-10-17)18-13-31(16-4-3-11-30(12-16)14-26)22-21(18)23(27)28-29-24(22)32/h1-2,5-10,13,16H,3-4,11-12H2,(H2,27,28)(H,29,32)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389984
PNG
(US9951077, 1)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H25N5O3/c1-2-22(32)30-14-6-7-18(15-30)31-16-21(23-24(31)26(33)29-28-25(23)27)17-10-12-20(13-11-17)34-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,27,28)(H,29,33)/t18-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390025
PNG
(4-amino-1-[1-[(E)-4- (dimethylamino)but-2-enoyl]-3...)
Show SMILES CN(C)C\C=C\C(=O)N1CCCC(C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1/C29H32N6O3/c1-33(2)16-7-11-25(36)34-17-6-8-21(18-34)35-19-24(26-27(35)29(37)32-31-28(26)30)20-12-14-23(15-13-20)38-22-9-4-3-5-10-22/h3-5,7,9-15,19,21H,6,8,16-18H2,1-2H3,(H2,30,31)(H,32,37)/b11-7+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390026
PNG
(4-amino-1-[(3R)-1-[(E)-4- (dimethylamino)but-2- en...)
Show SMILES CN(C)C\C=C\C(=O)N1CC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C28H30N6O3/c1-32(2)15-6-9-24(35)33-16-14-20(17-33)34-18-23(25-26(34)28(36)31-30-27(25)29)19-10-12-22(13-11-19)37-21-7-4-3-5-8-21/h3-13,18,20H,14-17H2,1-2H3,(H2,29,30)(H,31,36)/b9-6+/t20-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390043
PNG
(US9951077, 56)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4F)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H24FN5O3/c1-2-22(33)31-13-5-6-17(14-31)32-15-19(23-24(32)26(34)30-29-25(23)28)16-9-11-18(12-10-16)35-21-8-4-3-7-20(21)27/h2-4,7-12,15,17H,1,5-6,13-14H2,(H2,28,29)(H,30,34)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390012
PNG
(4-amino-1-[(3R)-1-[(E)-4- (dimethylamino)but-2-eno...)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H32N6O3/c1-33(2)16-7-11-25(36)34-17-6-8-21(18-34)35-19-24(26-27(35)29(37)32-31-28(26)30)20-12-14-23(15-13-20)38-22-9-4-3-5-10-22/h3-5,7,9-15,19,21H,6,8,16-18H2,1-2H3,(H2,30,31)(H,32,37)/b11-7+/t21-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390013
PNG
(4-amino-1-[(3R)-1-[(E)-4- (diethylamino)but-2-enoy...)
Show SMILES CCN(CC)C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C31H36N6O3/c1-3-35(4-2)18-9-13-27(38)36-19-8-10-23(20-36)37-21-26(28-29(37)31(39)34-33-30(28)32)22-14-16-25(17-15-22)40-24-11-6-5-7-12-24/h5-7,9,11-17,21,23H,3-4,8,10,18-20H2,1-2H3,(H2,32,33)(H,34,39)/b13-9+/t23-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390022
PNG
(4-amino-1-[(3R)-1-[(E)-4- morpholinobut-2-enoyl]-3...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)\C=C\CN1CCOCC1
Show InChI InChI=1S/C31H34N6O4/c32-30-28-26(22-10-12-25(13-11-22)41-24-7-2-1-3-8-24)21-37(29(28)31(39)34-33-30)23-6-4-15-36(20-23)27(38)9-5-14-35-16-18-40-19-17-35/h1-3,5,7-13,21,23H,4,6,14-20H2,(H2,32,33)(H,34,39)/b9-5+/t23-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390045
PNG
(US9951077, 58)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4c(F)cccc4F)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H23F2N5O3/c1-2-21(34)32-12-4-5-16(13-32)33-14-18(22-23(33)26(35)31-30-25(22)29)15-8-10-17(11-9-15)36-24-19(27)6-3-7-20(24)28/h2-3,6-11,14,16H,1,4-5,12-13H2,(H2,29,30)(H,31,35)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390087
PNG
(US9951077, 99)
Show SMILES CN(C)CC#CC(=O)N1CC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C28H27FN6O3/c1-33(2)14-5-8-24(36)34-15-13-19(16-34)35-17-21(25-26(35)28(37)32-31-27(25)30)18-9-11-20(12-10-18)38-23-7-4-3-6-22(23)29/h3-4,6-7,9-12,17,19H,13-16H2,1-2H3,(H2,30,31)(H,32,37)/t19-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390020
PNG
(4-amino-1-[(3R)-1-[(E)-4-(azetidin- 1-yl)but-2-eno...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)\C=C\CN1CCC1
Show InChI InChI=1S/C30H32N6O3/c31-29-27-25(21-11-13-24(14-12-21)39-23-8-2-1-3-9-23)20-36(28(27)30(38)33-32-29)22-7-4-18-35(19-22)26(37)10-5-15-34-16-6-17-34/h1-3,5,8-14,20,22H,4,6-7,15-19H2,(H2,31,32)(H,33,38)/b10-5+/t22-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390032
PNG
(4-amino-1-[1-[(E)-4- (dimethylamino)but-2-enoyl]-4...)
Show SMILES CN(C)C\C=C\C(=O)N1CCC(F)C(C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1/C29H31FN6O3/c1-34(2)15-6-9-25(37)35-16-14-23(30)24(18-35)36-17-22(26-27(36)29(38)33-32-28(26)31)19-10-12-21(13-11-19)39-20-7-4-3-5-8-20/h3-13,17,23-24H,14-16,18H2,1-2H3,(H2,31,32)(H,33,38)/b9-6+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390038
PNG
(US9951077, 51)
Show SMILES COc1ccc(cc1)-c1cn(C2CCCN(C2)C(=O)C=C)c2c1c(N)n[nH]c2=O
Show InChI InChI=1/C21H23N5O3/c1-3-17(27)25-10-4-5-14(11-25)26-12-16(13-6-8-15(29-2)9-7-13)18-19(26)21(28)24-23-20(18)22/h3,6-9,12,14H,1,4-5,10-11H2,2H3,(H2,22,23)(H,24,28)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390044
PNG
(US9951077, 57)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H31FN6O3/c1-34(2)15-6-10-25(37)35-16-5-7-20(17-35)36-18-22(26-27(36)29(38)33-32-28(26)31)19-11-13-21(14-12-19)39-24-9-4-3-8-23(24)30/h3-4,6,8-14,18,20H,5,7,15-17H2,1-2H3,(H2,31,32)(H,33,38)/b10-6+/t20-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390095
PNG
(US9951077, 107)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCN(C1)C#N
Show InChI InChI=1S/C23H20N6O2/c24-14-28-11-10-16(12-28)29-13-19(20-21(29)23(30)27-26-22(20)25)15-6-8-18(9-7-15)31-17-4-2-1-3-5-17/h1-9,13,16H,10-12H2,(H2,25,26)(H,27,30)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390001
PNG
(US9951077, 18)
Show SMILES CNC\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C28H30N6O3/c1-30-15-5-10-24(35)33-16-6-7-20(17-33)34-18-23(25-26(34)28(36)32-31-27(25)29)19-11-13-22(14-12-19)37-21-8-3-2-4-9-21/h2-5,8-14,18,20,30H,6-7,15-17H2,1H3,(H2,29,31)(H,32,36)/b10-5+/t20-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390023
PNG
(4-amino-1-[(3R)-1-[(E)-4-(4- methylpiperazin-1-yl)...)
Show SMILES CN1CCN(C\C=C\C(=O)N2CCC[C@H](C2)n2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c23)CC1
Show InChI InChI=1S/C32H37N7O3/c1-36-17-19-37(20-18-36)15-6-10-28(40)38-16-5-7-24(21-38)39-22-27(29-30(39)32(41)35-34-31(29)33)23-11-13-26(14-12-23)42-25-8-3-2-4-9-25/h2-4,6,8-14,22,24H,5,7,15-21H2,1H3,(H2,33,34)(H,35,41)/b10-6+/t24-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389999
PNG
(US9951077, 16)
Show SMILES CC(C)N(C)C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C31H36N6O3/c1-21(2)35(3)17-8-12-27(38)36-18-7-9-23(19-36)37-20-26(28-29(37)31(39)34-33-30(28)32)22-13-15-25(16-14-22)40-24-10-5-4-6-11-24/h4-6,8,10-16,20-21,23H,7,9,17-19H2,1-3H3,(H2,32,33)(H,34,39)/b12-8+/t23-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390055
PNG
(US9951077, 68)
Show SMILES COc1cc(ccc1Oc1cccc(Cl)c1)-c1cn(C2CCCN(C2)C(=O)C=C)c2c1c(N)n[nH]c2=O
Show InChI InChI=1/C27H26ClN5O4/c1-3-23(34)32-11-5-7-18(14-32)33-15-20(24-25(33)27(35)31-30-26(24)29)16-9-10-21(22(12-16)36-2)37-19-8-4-6-17(28)13-19/h3-4,6,8-10,12-13,15,18H,1,5,7,11,14H2,2H3,(H2,29,30)(H,31,35)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390059
PNG
(US9951077, 72)
Show SMILES COc1cc(ccc1Oc1ccc(Cl)c(Cl)c1)-c1cn([C@@H]2CCCN(C2)C(=O)C=C)c2c1c(N)n[nH]c2=O
Show InChI InChI=1S/C27H25Cl2N5O4/c1-3-23(35)33-10-4-5-16(13-33)34-14-18(24-25(34)27(36)32-31-26(24)30)15-6-9-21(22(11-15)37-2)38-17-7-8-19(28)20(29)12-17/h3,6-9,11-12,14,16H,1,4-5,10,13H2,2H3,(H2,30,31)(H,32,36)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390061
PNG
(US9951077, 74)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)c(F)c3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H24FN5O3/c1-2-22(33)31-12-6-7-17(14-31)32-15-19(23-24(32)26(34)30-29-25(23)28)16-10-11-21(20(27)13-16)35-18-8-4-3-5-9-18/h2-5,8-11,13,15,17H,1,6-7,12,14H2,(H2,28,29)(H,30,34)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390104
PNG
(US9951077, 116)
Show SMILES C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3c(F)cccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C27H25F2N5O3/c1-2-5-22(35)33-13-4-6-17(14-33)34-15-19(23-24(34)27(36)32-31-26(23)30)16-9-11-18(12-10-16)37-25-20(28)7-3-8-21(25)29/h2-3,5,7-12,15,17H,4,6,13-14H2,1H3,(H2,30,31)(H,32,36)/b5-2+/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389993
PNG
(4-amino-3-(4-phenoxyphenyl)-1- [(1-prop-2-enoyl-4-...)
Show SMILES Nc1n[nH]c(=O)c2n(CC3CCN(CC3)C(=O)C=C)cc(-c3ccc(Oc4ccccc4)cc3)c12
Show InChI InChI=1S/C27H27N5O3/c1-2-23(33)31-14-12-18(13-15-31)16-32-17-22(24-25(32)27(34)30-29-26(24)28)19-8-10-21(11-9-19)35-20-6-4-3-5-7-20/h2-11,17-18H,1,12-16H2,(H2,28,29)(H,30,34)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389993
PNG
(4-amino-3-(4-phenoxyphenyl)-1- [(1-prop-2-enoyl-4-...)
Show SMILES Nc1n[nH]c(=O)c2n(CC3CCN(CC3)C(=O)C=C)cc(-c3ccc(Oc4ccccc4)cc3)c12
Show InChI InChI=1S/C27H27N5O3/c1-2-23(33)31-14-12-18(13-15-31)16-32-17-22(24-25(32)27(34)30-29-26(24)28)19-8-10-21(11-9-19)35-20-6-4-3-5-7-20/h2-11,17-18H,1,12-16H2,(H2,28,29)(H,30,34)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390008
PNG
(4-amino-1-[(3R)-1-[(E)-but-2- enoyl]-3-piperidyl]-...)
Show SMILES C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C27H27N5O3/c1-2-7-23(33)31-15-6-8-19(16-31)32-17-22(24-25(32)27(34)30-29-26(24)28)18-11-13-21(14-12-18)35-20-9-4-3-5-10-20/h2-5,7,9-14,17,19H,6,8,15-16H2,1H3,(H2,28,29)(H,30,34)/b7-2+/t19-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390048
PNG
(US9951077, 61)
Show SMILES CN(C)C\C=C\C(=O)N1CCCC(C1)n1cc(-c2ccc(Oc3ccc(F)cc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1/C29H31FN6O3/c1-34(2)15-4-6-25(37)35-16-3-5-21(17-35)36-18-24(26-27(36)29(38)33-32-28(26)31)19-7-11-22(12-8-19)39-23-13-9-20(30)10-14-23/h4,6-14,18,21H,3,5,15-17H2,1-2H3,(H2,31,32)(H,33,38)/b6-4+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390051
PNG
(US9951077, 64)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccc(Cl)cc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C26H24ClN5O3/c1-2-22(33)31-13-3-4-18(14-31)32-15-21(23-24(32)26(34)30-29-25(23)28)16-5-9-19(10-6-16)35-20-11-7-17(27)8-12-20/h2,5-12,15,18H,1,3-4,13-14H2,(H2,28,29)(H,30,34)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390060
PNG
(US9951077, 73)
Show SMILES COc1cc(ccc1Oc1ccc(Cl)c(Cl)c1)-c1cn([C@@H]2CCCN(C2)C(=O)\C=C\CN(C)C)c2c1c(N)n[nH]c2=O
Show InChI InChI=1S/C30H32Cl2N6O4/c1-36(2)12-5-7-26(39)37-13-4-6-19(16-37)38-17-21(27-28(38)30(40)35-34-29(27)33)18-8-11-24(25(14-18)41-3)42-20-9-10-22(31)23(32)15-20/h5,7-11,14-15,17,19H,4,6,12-13,16H2,1-3H3,(H2,33,34)(H,35,40)/b7-5+/t19-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390067
PNG
(US9951077, 80)
Show SMILES Nc1n[nH]c(=O)c2n([C@@H]3CCCN(C3)C(=O)C=C)c(Cl)c(-c3ccc(Oc4ccccc4)cc3)c12
Show InChI InChI=1S/C26H24ClN5O3/c1-2-20(33)31-14-6-7-17(15-31)32-23-22(25(28)29-30-26(23)34)21(24(32)27)16-10-12-19(13-11-16)35-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15H2,(H2,28,29)(H,30,34)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390080
PNG
(US9951077, 92)
Show SMILES CN(C)C\C=C\C(=O)Nc1cccc(c1)-n1cc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C30H27FN6O3/c1-36(2)16-6-11-26(38)33-20-7-5-8-21(17-20)37-18-23(27-28(37)30(39)35-34-29(27)32)19-12-14-22(15-13-19)40-25-10-4-3-9-24(25)31/h3-15,17-18H,16H2,1-2H3,(H2,32,34)(H,33,38)(H,35,39)/b11-6+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390081
PNG
(US9951077, 93)
Show SMILES CC#CC(=O)N1CC[C@H](C1)n1cc(-c2ccc(Oc3c(F)cccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C26H21F2N5O3/c1-2-4-21(34)32-12-11-16(13-32)33-14-18(22-23(33)26(35)31-30-25(22)29)15-7-9-17(10-8-15)36-24-19(27)5-3-6-20(24)28/h3,5-10,14,16H,11-13H2,1H3,(H2,29,30)(H,31,35)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390084
PNG
(US9951077, 96)
Show SMILES CC#CC(=O)N1CC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3Cl)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C26H22ClN5O3/c1-2-5-22(33)31-13-12-17(14-31)32-15-19(23-24(32)26(34)30-29-25(23)28)16-8-10-18(11-9-16)35-21-7-4-3-6-20(21)27/h3-4,6-11,15,17H,12-14H2,1H3,(H2,28,29)(H,30,34)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390092
PNG
(US9951077, 104)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4F)cc3)c12)C1CCC(CC1)NC(=O)C=C
Show InChI InChI=1S/C27H26FN5O3/c1-2-23(34)30-17-9-11-18(12-10-17)33-15-20(24-25(33)27(35)32-31-26(24)29)16-7-13-19(14-8-16)36-22-6-4-3-5-21(22)28/h2-8,13-15,17-18H,1,9-12H2,(H2,29,31)(H,30,34)(H,32,35)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390094
PNG
(US9951077, 106)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4F)cc3)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H22FN5O3/c1-2-21(32)30-12-11-16(13-30)31-14-18(22-23(31)25(33)29-28-24(22)27)15-7-9-17(10-8-15)34-20-6-4-3-5-19(20)26/h2-10,14,16H,1,11-13H2,(H2,27,28)(H,29,33)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389988
PNG
(4-amino-3-(4-phenoxyphenyl)-1-(1- prop-2-enoylazet...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CN(C1)C(=O)C=C
Show InChI InChI=1S/C24H21N5O3/c1-2-20(30)28-12-16(13-28)29-14-19(21-22(29)24(31)27-26-23(21)25)15-8-10-18(11-9-15)32-17-6-4-3-5-7-17/h2-11,14,16H,1,12-13H2,(H2,25,26)(H,27,31)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390002
PNG
(US9951077, 19)
Show SMILES CCC(=O)N1CCCC(C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1/C26H27N5O3/c1-2-22(32)30-14-6-7-18(15-30)31-16-21(23-24(31)26(33)29-28-25(23)27)17-10-12-20(13-11-17)34-19-8-4-3-5-9-19/h3-5,8-13,16,18H,2,6-7,14-15H2,1H3,(H2,27,28)(H,29,33)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390019
PNG
(4-amino-1-[(3R)-1-[(E)-4- [cyclohexyl(methyl)amino...)
Show SMILES CN(C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12)C1CCCCC1
Show InChI InChI=1S/C34H40N6O3/c1-38(25-10-4-2-5-11-25)20-9-15-30(41)39-21-8-12-26(22-39)40-23-29(31-32(40)34(42)37-36-33(31)35)24-16-18-28(19-17-24)43-27-13-6-3-7-14-27/h3,6-7,9,13-19,23,25-26H,2,4-5,8,10-12,20-22H2,1H3,(H2,35,36)(H,37,42)/b15-9+/t26-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390035
PNG
((E)-N-[3-[4-amino-7-oxo-3-(4- phenoxyphenyl)-6H-py...)
Show SMILES CN(C)C\C=C\C(=O)NC1C2CCC1CC(C2)n1cc(-c2ccc(Oc3ccccc3)cc2)c2cn[nH]c(=O)c12
Show InChI InChI=1/C32H35N5O3/c1-36(2)16-6-9-29(38)34-30-22-10-11-23(30)18-24(17-22)37-20-28(27-19-33-35-32(39)31(27)37)21-12-14-26(15-13-21)40-25-7-4-3-5-8-25/h3-9,12-15,19-20,22-24,30H,10-11,16-18H2,1-2H3,(H,34,38)(H,35,39)/b9-6+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390036
PNG
(4-amino-1-[(3R)-1-[(E)-4- (dimethylamino)but-2-eno...)
Show SMILES CN(C)C\C=C\C(=O)N1C[C@@H](CC(F)(F)C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H30F2N6O3/c1-35(2)14-6-9-24(38)36-16-20(15-29(30,31)18-36)37-17-23(25-26(37)28(39)34-33-27(25)32)19-10-12-22(13-11-19)40-21-7-4-3-5-8-21/h3-13,17,20H,14-16,18H2,1-2H3,(H2,32,33)(H,34,39)/b9-6+/t20-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390046
PNG
(US9951077, 59)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3c(F)cccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H30F2N6O3/c1-35(2)14-5-9-24(38)36-15-4-6-19(16-36)37-17-21(25-26(37)29(39)34-33-28(25)32)18-10-12-20(13-11-18)40-27-22(30)7-3-8-23(27)31/h3,5,7-13,17,19H,4,6,14-16H2,1-2H3,(H2,32,33)(H,34,39)/b9-5+/t19-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390091
PNG
(US9951077, 103)
Show SMILES NC(=O)C#CCC1CCC(CC1)n1cc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C28H26FN5O3/c29-22-5-1-2-6-23(22)37-20-14-10-18(11-15-20)21-16-34(26-25(21)27(31)32-33-28(26)36)19-12-8-17(9-13-19)4-3-7-24(30)35/h1-2,5-6,10-11,14-17,19H,4,8-9,12-13H2,(H2,30,35)(H2,31,32)(H,33,36)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390100
PNG
(US9951077, 112)
Show SMILES CC#CC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C25H21FN6O3/c1-2-5-20(33)31-13-12-16(14-31)32-23-21(24(27)28-29-25(23)34)22(30-32)15-8-10-17(11-9-15)35-19-7-4-3-6-18(19)26/h3-4,6-11,16H,12-14H2,1H3,(H2,27,28)(H,29,34)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390103
PNG
(US9951077, 115)
Show SMILES CCC(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3c(F)cccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C26H25F2N5O3/c1-2-21(34)32-12-4-5-16(13-32)33-14-18(22-23(33)26(35)31-30-25(22)29)15-8-10-17(11-9-15)36-24-19(27)6-3-7-20(24)28/h3,6-11,14,16H,2,4-5,12-13H2,1H3,(H2,29,30)(H,31,35)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389991
PNG
(4-amino-3-(4-phenoxyphenyl)-1- [(1-prop-2-enoylpyr...)
Show SMILES Nc1n[nH]c(=O)c2n(CC3CCN(C3)C(=O)C=C)cc(-c3ccc(Oc4ccccc4)cc3)c12
Show InChI InChI=1/C26H25N5O3/c1-2-22(32)30-13-12-17(14-30)15-31-16-21(23-24(31)26(33)29-28-25(23)27)18-8-10-20(11-9-18)34-19-6-4-3-5-7-19/h2-11,16-17H,1,12-15H2,(H2,27,28)(H,29,33)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390003
PNG
(US9951077, 20)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C#N
Show InChI InChI=1S/C24H22N6O2/c25-15-29-12-4-5-17(13-29)30-14-20(21-22(30)24(31)28-27-23(21)26)16-8-10-19(11-9-16)32-18-6-2-1-3-7-18/h1-3,6-11,14,17H,4-5,12-13H2,(H2,26,27)(H,28,31)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390028
PNG
(4-amino-1-[[(2S)-1-[(E)-4- (dimethylamino)but-2- e...)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@H]1Cn1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H32N6O3/c1-33(2)16-7-11-25(36)35-17-6-8-21(35)18-34-19-24(26-27(34)29(37)32-31-28(26)30)20-12-14-23(15-13-20)38-22-9-4-3-5-10-22/h3-5,7,9-15,19,21H,6,8,16-18H2,1-2H3,(H2,30,31)(H,32,37)/b11-7+/t21-/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390033
PNG
((E)-N-[4-[4-amino-7-oxo-3-(4- phenoxyphenyl)-6H-py...)
Show SMILES CN(C)C\C=C\C(=O)NC1CCC(CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C30H34N6O3/c1-35(2)18-6-9-26(37)32-21-12-14-22(15-13-21)36-19-25(27-28(36)30(38)34-33-29(27)31)20-10-16-24(17-11-20)39-23-7-4-3-5-8-23/h3-11,16-17,19,21-22H,12-15,18H2,1-2H3,(H2,31,33)(H,32,37)(H,34,38)/b9-6+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390047
PNG
(US9951077, 60)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccc(F)cc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C26H24FN5O3/c1-2-22(33)31-13-3-4-18(14-31)32-15-21(23-24(32)26(34)30-29-25(23)28)16-5-9-19(10-6-16)35-20-11-7-17(27)8-12-20/h2,5-12,15,18H,1,3-4,13-14H2,(H2,28,29)(H,30,34)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390053
PNG
(US9951077, 66)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4cccc(Cl)c4)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C26H24ClN5O3/c1-2-22(33)31-12-4-6-18(14-31)32-15-21(23-24(32)26(34)30-29-25(23)28)16-8-10-19(11-9-16)35-20-7-3-5-17(27)13-20/h2-3,5,7-11,13,15,18H,1,4,6,12,14H2,(H2,28,29)(H,30,34)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390063
PNG
(US9951077, 76)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3F)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H24FN5O3/c1-2-22(33)31-12-6-7-16(14-31)32-15-20(23-24(32)26(34)30-29-25(23)28)19-11-10-18(13-21(19)27)35-17-8-4-3-5-9-17/h2-5,8-11,13,15-16H,1,6-7,12,14H2,(H2,28,29)(H,30,34)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390082
PNG
(US9951077, 94)
Show SMILES CC#CC(=O)N1CC[C@H](C1)n1cc(-c2ccc(Oc3c(F)cccc3Cl)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C26H21ClFN5O3/c1-2-4-21(34)32-12-11-16(13-32)33-14-18(22-23(33)26(35)31-30-25(22)29)15-7-9-17(10-8-15)36-24-19(27)5-3-6-20(24)28/h3,5-10,14,16H,11-13H2,1H3,(H2,29,30)(H,31,35)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390101
PNG
(US9951077, 113)
Show SMILES CC#CC(=O)N1CC[C@H](C1)n1nc(-c2ccc(Oc3c(F)cccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C25H20F2N6O3/c1-2-4-19(34)32-12-11-15(13-32)33-22-20(24(28)29-30-25(22)35)21(31-33)14-7-9-16(10-8-14)36-23-17(26)5-3-6-18(23)27/h3,5-10,15H,11-13H2,1H3,(H2,28,29)(H,30,35)/t15-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390000
PNG
(US9951077, 17)
Show SMILES CN(C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12)C(=O)OC(C)(C)C
Show InChI InChI=1S/C33H38N6O5/c1-33(2,3)44-32(42)37(4)18-9-13-27(40)38-19-8-10-23(20-38)39-21-26(28-29(39)31(41)36-35-30(28)34)22-14-16-25(17-15-22)43-24-11-6-5-7-12-24/h5-7,9,11-17,21,23H,8,10,18-20H2,1-4H3,(H2,34,35)(H,36,41)/b13-9+/t23-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390049
PNG
(US9951077, 62)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4cccc(F)c4)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1/C26H24FN5O3/c1-2-22(33)31-12-4-6-18(14-31)32-15-21(23-24(32)26(34)30-29-25(23)28)16-8-10-19(11-9-16)35-20-7-3-5-17(27)13-20/h2-3,5,7-11,13,15,18H,1,4,6,12,14H2,(H2,28,29)(H,30,34)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390071
PNG
(US9951077, 84)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4c(F)cccc4F)cc3)c12)[C@@H]1CCCN(C1)C#N
Show InChI InChI=1S/C24H20F2N6O2/c25-18-4-1-5-19(26)22(18)34-16-8-6-14(7-9-16)17-12-32(15-3-2-10-31(11-15)13-27)21-20(17)23(28)29-30-24(21)33/h1,4-9,12,15H,2-3,10-11H2,(H2,28,29)(H,30,33)/t15-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390088
PNG
(US9951077, 100)
Show SMILES CC#CC(=O)NC1CCC(C1)n1cc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1/C27H24FN5O3/c1-2-5-23(34)30-17-10-11-18(14-17)33-15-20(24-25(33)27(35)32-31-26(24)29)16-8-12-19(13-9-16)36-22-7-4-3-6-21(22)28/h3-4,6-9,12-13,15,17-18H,10-11,14H2,1H3,(H2,29,31)(H,30,34)(H,32,35)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390097
PNG
(US9951077, 109)
Show SMILES Nc1n[nH]c(=O)c2n(nc(-c3ccc(Oc4ccccc4F)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H23FN6O3/c1-2-20(33)31-13-5-6-16(14-31)32-23-21(24(27)28-29-25(23)34)22(30-32)15-9-11-17(12-10-15)35-19-8-4-3-7-18(19)26/h2-4,7-12,16H,1,5-6,13-14H2,(H2,27,28)(H,29,34)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390017
PNG
(4-amino-1-[(3R)-1-[(E)-4- [cyclopropyl(ethyl)amino...)
Show SMILES CCN(C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12)C1CC1
Show InChI InChI=1S/C32H36N6O3/c1-2-36(23-14-15-23)18-7-11-28(39)37-19-6-8-24(20-37)38-21-27(29-30(38)32(40)35-34-31(29)33)22-12-16-26(17-13-22)41-25-9-4-3-5-10-25/h3-5,7,9-13,16-17,21,23-24H,2,6,8,14-15,18-20H2,1H3,(H2,33,34)(H,35,40)/b11-7+/t24-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390037
PNG
(US9951077, 50)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C(=C\C1CC1)\C#N
Show InChI InChI=1S/C30H28N6O3/c31-16-21(15-19-8-9-19)30(38)35-14-4-5-22(17-35)36-18-25(26-27(36)29(37)34-33-28(26)32)20-10-12-24(13-11-20)39-23-6-2-1-3-7-23/h1-3,6-7,10-13,15,18-19,22H,4-5,8-9,14,17H2,(H2,32,33)(H,34,37)/b21-15+/t22-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390057
PNG
(US9951077, 70)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4Cl)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H24ClN5O3/c1-2-22(33)31-13-5-6-17(14-31)32-15-19(23-24(32)26(34)30-29-25(23)28)16-9-11-18(12-10-16)35-21-8-4-3-7-20(21)27/h2-4,7-12,15,17H,1,5-6,13-14H2,(H2,28,29)(H,30,34)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390077
PNG
(US9951077, 89)
Show SMILES COc1ccc(cc1Cl)-c1cn(-c2cccc(NC(=O)C=C)c2)c2c1c(N)n[nH]c2=O
Show InChI InChI=1S/C22H18ClN5O3/c1-3-18(29)25-13-5-4-6-14(10-13)28-11-15(12-7-8-17(31-2)16(23)9-12)19-20(28)22(30)27-26-21(19)24/h3-11H,1H2,2H3,(H2,24,26)(H,25,29)(H,27,30)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390079
PNG
(US9951077, 91)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4F)cc3)c12)-c1cccc(NC(=O)C=C)c1
Show InChI InChI=1S/C27H20FN5O3/c1-2-23(34)30-17-6-5-7-18(14-17)33-15-20(24-25(33)27(35)32-31-26(24)29)16-10-12-19(13-11-16)36-22-9-4-3-8-21(22)28/h2-15H,1H2,(H2,29,31)(H,30,34)(H,32,35)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390085
PNG
(US9951077, 97)
Show SMILES CC#CC(=O)N1CC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C26H23N5O3/c1-2-6-22(32)30-14-13-18(15-30)31-16-21(23-24(31)26(33)29-28-25(23)27)17-9-11-20(12-10-17)34-19-7-4-3-5-8-19/h3-5,7-12,16,18H,13-15H2,1H3,(H2,27,28)(H,29,33)/t18-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390090
PNG
(US9951077, 102)
Show SMILES CC#CC(=O)N[C@H]1CC[C@H](CC1)n1cc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C28H26FN5O3/c1-2-5-24(35)31-18-10-12-19(13-11-18)34-16-21(25-26(34)28(36)33-32-27(25)30)17-8-14-20(15-9-17)37-23-7-4-3-6-22(23)29/h3-4,6-9,14-16,18-19H,10-13H2,1H3,(H2,30,32)(H,31,35)(H,33,36)/t18-,19+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389986
PNG
(4-amino-3-(4-phenoxyphenyl)-1- [(3S)-1-prop-2-enoy...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H23N5O3/c1-2-21(31)29-13-12-17(14-29)30-15-20(22-23(30)25(32)28-27-24(22)26)16-8-10-19(11-9-16)33-18-6-4-3-5-7-18/h2-11,15,17H,1,12-14H2,(H2,26,27)(H,28,32)/t17-/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390005
PNG
(4-amino-1-[(3R)-1-(2-chloroacetyl)- 3-piperidyl]-3...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)CCl
Show InChI InChI=1S/C25H24ClN5O3/c26-13-21(32)30-12-4-5-17(14-30)31-15-20(22-23(31)25(33)29-28-24(22)27)16-8-10-19(11-9-16)34-18-6-2-1-3-7-18/h1-3,6-11,15,17H,4-5,12-14H2,(H2,27,28)(H,29,33)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390052
PNG
(US9951077, 65)
Show SMILES CN(C)C\C=C\C(=O)N1CCCC(C1)n1cc(-c2ccc(Oc3ccc(Cl)cc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1/C29H31ClN6O3/c1-34(2)15-4-6-25(37)35-16-3-5-21(17-35)36-18-24(26-27(36)29(38)33-32-28(26)31)19-7-11-22(12-8-19)39-23-13-9-20(30)10-14-23/h4,6-14,18,21H,3,5,15-17H2,1-2H3,(H2,31,32)(H,33,38)/b6-4+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390072
PNG
(US9951077, 85)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)c(F)c3)c12)[C@@H]1CCCN(C1)C#N
Show InChI InChI=1S/C24H21FN6O2/c25-19-11-15(8-9-20(19)33-17-6-2-1-3-7-17)18-13-31(16-5-4-10-30(12-16)14-26)22-21(18)23(27)28-29-24(22)32/h1-3,6-9,11,13,16H,4-5,10,12H2,(H2,27,28)(H,29,32)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390086
PNG
(US9951077, 98)
Show SMILES CO[C@H]1CN(C[C@@H]1n1cc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12)C(=O)C#CC
Show InChI InChI=1S/C27H24FN5O4/c1-3-6-23(34)32-14-20(22(15-32)36-2)33-13-18(24-25(33)27(35)31-30-26(24)29)16-9-11-17(12-10-16)37-21-8-5-4-7-19(21)28/h4-5,7-13,20,22H,14-15H2,1-2H3,(H2,29,30)(H,31,35)/t20-,22-/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390098
PNG
(US9951077, 110)
Show SMILES Nc1n[nH]c(=O)c2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O3/c1-2-20(32)30-14-6-7-17(15-30)31-23-21(24(26)27-28-25(23)33)22(29-31)16-10-12-19(13-11-16)34-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15H2,(H2,26,27)(H,28,33)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390107
PNG
(US9951077, 117)
Show SMILES CC#CC(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3c(F)cccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C27H23F2N5O3/c1-2-5-22(35)33-13-4-6-17(14-33)34-15-19(23-24(34)27(36)32-31-26(23)30)16-9-11-18(12-10-16)37-25-20(28)7-3-8-21(25)29/h3,7-12,15,17H,4,6,13-14H2,1H3,(H2,30,31)(H,32,36)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389985
PNG
(4-amino-3-(4-phenoxyphenyl)-1-(1- prop-2-enoyl-3-p...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H23N5O3/c1-2-21(31)29-13-12-17(14-29)30-15-20(22-23(30)25(32)28-27-24(22)26)16-8-10-19(11-9-16)33-18-6-4-3-5-7-18/h2-11,15,17H,1,12-14H2,(H2,26,27)(H,28,32)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390007
PNG
(3-[(3R)-3-[4-amino-7-oxo-3-(4- phenoxyphenyl)-6H-p...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)CC#N
Show InChI InChI=1S/C26H24N6O3/c27-13-12-22(33)31-14-4-5-18(15-31)32-16-21(23-24(32)26(34)30-29-25(23)28)17-8-10-20(11-9-17)35-19-6-2-1-3-7-19/h1-3,6-11,16,18H,4-5,12,14-15H2,(H2,28,29)(H,30,34)/t18-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390027
PNG
(4-amino-1-[1-[(E)-4- (dimethylamino)but-2- enoyl]a...)
Show SMILES CN(C)C\C=C\C(=O)N1CC(C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C27H28N6O3/c1-31(2)14-6-9-23(34)32-15-19(16-32)33-17-22(24-25(33)27(35)30-29-26(24)28)18-10-12-21(13-11-18)36-20-7-4-3-5-8-20/h3-13,17,19H,14-16H2,1-2H3,(H2,28,29)(H,30,35)/b9-6+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390030
PNG
(4-amino-1-[[1-[(E)-4- (dimethylamino)but-2- enoyl]...)
Show SMILES CN(C)C\C=C\C(=O)N1CCC(Cn2cc(-c3ccc(Oc4ccccc4)cc3)c3c(N)n[nH]c(=O)c23)C1
Show InChI InChI=1/C29H32N6O3/c1-33(2)15-6-9-25(36)34-16-14-20(17-34)18-35-19-24(26-27(35)29(37)32-31-28(26)30)21-10-12-23(13-11-21)38-22-7-4-3-5-8-22/h3-13,19-20H,14-18H2,1-2H3,(H2,30,31)(H,32,37)/b9-6+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390031
PNG
(4-amino-1-[1-[(E)-4- (dimethylamino)but-2-enoyl]-4...)
Show SMILES CN(C)C\C=C\C(=O)N1CCC(CC1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H32N6O3/c1-33(2)16-6-9-25(36)34-17-14-21(15-18-34)35-19-24(26-27(35)29(37)32-31-28(26)30)20-10-12-23(13-11-20)38-22-7-4-3-5-8-22/h3-13,19,21H,14-18H2,1-2H3,(H2,30,31)(H,32,37)/b9-6+
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390068
PNG
(US9951077, 81)
Show SMILES Nc1n[nH]c(=O)c2n([C@@H]3CCCN(C3)C(=O)C=C)c(F)c(-c3ccc(Oc4ccccc4)cc3)c12
Show InChI InChI=1S/C26H24FN5O3/c1-2-20(33)31-14-6-7-17(15-31)32-23-22(25(28)29-30-26(23)34)21(24(32)27)16-10-12-19(13-11-16)35-18-8-4-3-5-9-18/h2-5,8-13,17H,1,6-7,14-15H2,(H2,28,29)(H,30,34)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390078
PNG
(US9951077, 90)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)-c1ccc(NC(=O)C=C)cc1
Show InChI InChI=1S/C27H21N5O3/c1-2-23(33)29-18-10-12-19(13-11-18)32-16-22(24-25(32)27(34)31-30-26(24)28)17-8-14-21(15-9-17)35-20-6-4-3-5-7-20/h2-16H,1H2,(H2,28,30)(H,29,33)(H,31,34)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390083
PNG
(US9951077, 95)
Show SMILES CC#CC(=O)N1CC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C26H22FN5O3/c1-2-5-22(33)31-13-12-17(14-31)32-15-19(23-24(32)26(34)30-29-25(23)28)16-8-10-18(11-9-16)35-21-7-4-3-6-20(21)27/h3-4,6-11,15,17H,12-14H2,1H3,(H2,28,29)(H,30,34)/t17-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390093
PNG
(US9951077, 105)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4F)cc3)c12)C1CC[C@@H](CC1)NC(=O)C=C
Show InChI InChI=1/C27H26FN5O3/c1-2-23(34)30-17-9-11-18(12-10-17)33-15-20(24-25(33)27(35)32-31-26(24)29)16-7-13-19(14-8-16)36-22-6-4-3-5-21(22)28/h2-8,13-15,17-18H,1,9-12H2,(H2,29,31)(H,30,34)(H,32,35)/t17-,18?
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390102
PNG
(US9951077, 114)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4c(F)cccc4F)cc3)c12)[C@H]1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C26H23F2N5O3/c1-2-21(34)32-12-4-5-16(13-32)33-14-18(22-23(33)26(35)31-30-25(22)29)15-8-10-17(11-9-15)36-24-19(27)6-3-7-20(24)28/h2-3,6-11,14,16H,1,4-5,12-13H2,(H2,29,30)(H,31,35)/t16-/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389989
PNG
(4-amino-3-(4-phenoxyphenyl)-1- [[(2S)-1-prop-2-eno...)
Show SMILES Nc1n[nH]c(=O)c2n(C[C@@H]3CCCN3C(=O)C=C)cc(-c3ccc(Oc4ccccc4)cc3)c12
Show InChI InChI=1S/C26H25N5O3/c1-2-22(32)31-14-6-7-18(31)15-30-16-21(23-24(30)26(33)29-28-25(23)27)17-10-12-20(13-11-17)34-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,27,28)(H,29,33)/t18-/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389995
PNG
(4-amino-3-(4-phenoxyphenyl)-1- [(1-prop-2-enoylaze...)
Show SMILES Nc1n[nH]c(=O)c2n(CC3CN(C3)C(=O)C=C)cc(-c3ccc(Oc4ccccc4)cc3)c12
Show InChI InChI=1S/C25H23N5O3/c1-2-21(31)29-12-16(13-29)14-30-15-20(22-23(30)25(32)28-27-24(22)26)17-8-10-19(11-9-17)33-18-6-4-3-5-7-18/h2-11,15-16H,1,12-14H2,(H2,26,27)(H,28,32)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389998
PNG
(US9951077, 15)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CC2CCC(C1)C2NC(=O)C=C
Show InChI InChI=1/C29H29N5O3/c1-2-24(35)31-26-18-8-9-19(26)15-20(14-18)34-16-23(25-27(34)29(36)33-32-28(25)30)17-10-12-22(13-11-17)37-21-6-4-3-5-7-21/h2-7,10-13,16,18-20,26H,1,8-9,14-15H2,(H2,30,32)(H,31,35)(H,33,36)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390006
PNG
(4-amino-1-[(3R)-1- (cyclopropanecarbonyl)-3- piper...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)[C@@H]1CCCN(C1)C(=O)C1CC1
Show InChI InChI=1S/C27H27N5O3/c28-25-23-22(17-10-12-21(13-11-17)35-20-6-2-1-3-7-20)16-32(24(23)26(33)30-29-25)19-5-4-14-31(15-19)27(34)18-8-9-18/h1-3,6-7,10-13,16,18-19H,4-5,8-9,14-15H2,(H2,28,29)(H,30,33)/t19-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390016
PNG
(4-amino-1-[(3R)-1-[(E)-4- (cyclopropyl(methyl)amin...)
Show SMILES CN(C\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12)C1CC1
Show InChI InChI=1S/C31H34N6O3/c1-35(22-13-14-22)17-6-10-27(38)36-18-5-7-23(19-36)37-20-26(28-29(37)31(39)34-33-30(28)32)21-11-15-25(16-12-21)40-24-8-3-2-4-9-24/h2-4,6,8-12,15-16,20,22-23H,5,7,13-14,17-19H2,1H3,(H2,32,33)(H,34,39)/b10-6+/t23-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389992
PNG
(4-amino-3-(4-phenoxyphenyl)-1-(1- prop-2-enoyl-4-p...)
Show SMILES Nc1n[nH]c(=O)c2n(cc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCN(CC1)C(=O)C=C
Show InChI InChI=1S/C26H25N5O3/c1-2-22(32)30-14-12-18(13-15-30)31-16-21(23-24(31)26(33)29-28-25(23)27)17-8-10-20(11-9-17)34-19-6-4-3-5-7-19/h2-11,16,18H,1,12-15H2,(H2,27,28)(H,29,33)
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n/an/a 5.05E+4n/an/an/an/an/an/a



Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390024
PNG
(4-amino-1-[(3R)-1-[(E)-4- methoxybut-2-enoyl]-3-pi...)
Show SMILES COC\C=C\C(=O)N1CCC[C@H](C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C28H29N5O4/c1-36-16-6-10-24(34)32-15-5-7-20(17-32)33-18-23(25-26(33)28(35)31-30-27(25)29)19-11-13-22(14-12-19)37-21-8-3-2-4-9-21/h2-4,6,8-14,18,20H,5,7,15-17H2,1H3,(H2,29,30)(H,31,35)/b10-6+/t20-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390029
PNG
(4-amino-1-[[(2R)-1-[(E)-4- (dimethylamino)but-2- e...)
Show SMILES CN(C)C\C=C\C(=O)N1CCC[C@@H]1Cn1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C29H32N6O3/c1-33(2)16-7-11-25(36)35-17-6-8-21(35)18-34-19-24(26-27(34)29(37)32-31-28(26)30)20-12-14-23(15-13-20)38-22-9-4-3-5-10-22/h3-5,7,9-15,19,21H,6,8,16-18H2,1-2H3,(H2,30,31)(H,32,37)/b11-7+/t21-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM389990
PNG
(4-amino-3-(4-phenoxyphenyl)-1- [[(2R)-1-prop-2-eno...)
Show SMILES Nc1n[nH]c(=O)c2n(C[C@H]3CCCN3C(=O)C=C)cc(-c3ccc(Oc4ccccc4)cc3)c12
Show InChI InChI=1S/C26H25N5O3/c1-2-22(32)31-14-6-7-18(31)15-30-16-21(23-24(30)26(33)29-28-25(23)27)17-10-12-20(13-11-17)34-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,27,28)(H,29,33)/t18-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390073
PNG
(US9951077, 86)
Show SMILES Nc1n[nH]c(=O)c2n([C@@H]3CCCN(C3)C#N)c(Cl)c(-c3ccc(Oc4ccccc4F)cc3)c12
Show InChI InChI=1S/C24H20ClFN6O2/c25-22-19(14-7-9-16(10-8-14)34-18-6-2-1-5-17(18)26)20-21(24(33)30-29-23(20)28)32(22)15-4-3-11-31(12-15)13-27/h1-2,5-10,15H,3-4,11-12H2,(H2,28,29)(H,30,33)/t15-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390070
PNG
(US9951077, 83)
Show SMILES Nc1n[nH]c(=O)c2n([C@@H]3CCCN(C3)C(=O)C=C)c(Cl)c(-c3ccc(Oc4ccccc4F)cc3)c12
Show InChI InChI=1S/C26H23ClFN5O3/c1-2-20(34)32-13-5-6-16(14-32)33-23-22(25(29)30-31-26(23)35)21(24(33)27)15-9-11-17(12-10-15)36-19-8-4-3-7-18(19)28/h2-4,7-12,16H,1,5-6,13-14H2,(H2,29,30)(H,31,35)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390108
PNG
(US9951077, 118)
Show SMILES CCCC(=O)N1CC[C@H](C1)n1cc(-c2ccc(Oc3c(F)cccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C26H25F2N5O3/c1-2-4-21(34)32-12-11-16(13-32)33-14-18(22-23(33)26(35)31-30-25(22)29)15-7-9-17(10-8-15)36-24-19(27)5-3-6-20(24)28/h3,5-10,14,16H,2,4,11-13H2,1H3,(H2,29,30)(H,31,35)/t16-/m1/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390004
PNG
(US9951077, 21)
Show SMILES CC#CC(=O)N1CCCC(C1)n1cc(-c2ccc(Oc3ccccc3)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1/C27H25N5O3/c1-2-7-23(33)31-15-6-8-19(16-31)32-17-22(24-25(32)27(34)30-29-26(24)28)18-11-13-21(14-12-18)35-20-9-4-3-5-10-20/h3-5,9-14,17,19H,6,8,15-16H2,1H3,(H2,28,29)(H,30,34)
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM390089
PNG
(US9951077, 101)
Show SMILES CC#CC(=O)N1CC[C@@H](C1)n1cc(-c2ccc(Oc3ccccc3F)cc2)c2c(N)n[nH]c(=O)c12
Show InChI InChI=1S/C26H22FN5O3/c1-2-5-22(33)31-13-12-17(14-31)32-15-19(23-24(32)26(34)30-29-25(23)28)16-8-10-18(11-9-16)35-21-7-4-3-6-20(21)27/h3-4,6-11,15,17H,12-14H2,1H3,(H2,28,29)(H,30,34)/t17-/m0/s1
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Jiangsu Hengrui Medicine Co., Ltd.

US Patent


Assay Description
The Btk kinase assay was performed using a ADP-Glo Btk kinase assay kit purchased from Promega (Madison, Wis.). The assay was conducted according to ...


US Patent US9951077 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%