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Patent code US9957261

Compile Data Set for Download or QSAR
Found 118 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390718
PNG
((S)-1-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)Nc3ccc(Cl)cc3)ccc2C1
Show InChI InChI=1S/C17H18ClN3O/c18-13-3-7-15(8-4-13)20-17(22)21-16-6-2-11-9-14(19)5-1-12(11)10-16/h2-4,6-8,10,14H,1,5,9,19H2,(H2,20,21,22)/t14-/m0/s1
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0.5n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390701
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3ccc4ccccc4c3)ccc2C1
Show InChI InChI=1S/C21H20N2O/c22-19-9-7-17-13-20(10-8-16(17)12-19)23-21(24)18-6-5-14-3-1-2-4-15(14)11-18/h1-6,8,10-11,13,19H,7,9,12,22H2,(H,23,24)/t19-/m0/s1
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0.600n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390723
PNG
((S)-6-Amino-N-(3-(trifluoromethoxy)phenyl)-5,6,7,8...)
Show SMILES N[C@H]1CCc2cc(ccc2C1)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H17F3N2O2/c19-18(20,21)25-16-3-1-2-15(10-16)23-17(24)13-5-4-12-9-14(22)7-6-11(12)8-13/h1-5,8,10,14H,6-7,9,22H2,(H,23,24)/t14-/m0/s1
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0.800n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390729
PNG
((R)-N-(3-Aminochroman-7-yl)-1-methyl-5-(thiophen-2...)
Show SMILES Cn1nc(cc1-c1cccs1)C(=O)Nc1ccc2C[C@@H](N)COc2c1
Show InChI InChI=1S/C18H18N4O2S/c1-22-15(17-3-2-6-25-17)9-14(21-22)18(23)20-13-5-4-11-7-12(19)10-24-16(11)8-13/h2-6,8-9,12H,7,10,19H2,1H3,(H,20,23)/t12-/m1/s1
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0.900n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390723
PNG
((S)-6-Amino-N-(3-(trifluoromethoxy)phenyl)-5,6,7,8...)
Show SMILES N[C@H]1CCc2cc(ccc2C1)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H17F3N2O2/c19-18(20,21)25-16-3-1-2-15(10-16)23-17(24)13-5-4-12-9-14(22)7-6-11(12)8-13/h1-5,8,10,14H,6-7,9,22H2,(H,23,24)/t14-/m0/s1
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0.900n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390716
PNG
((S)-1-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)Nc3ccc(cc3)C3CC3)ccc2C1
Show InChI InChI=1S/C20H23N3O/c21-17-7-3-16-12-19(10-6-15(16)11-17)23-20(24)22-18-8-4-14(5-9-18)13-1-2-13/h4-6,8-10,12-13,17H,1-3,7,11,21H2,(H2,22,23,24)/t17-/m0/s1
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0.900n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390731
PNG
((R)-N-(3-Aminochroman-7-yl)-3,4-difluorobenzamide ...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3ccc(F)c(F)c3)ccc2C1
Show InChI InChI=1S/C16H14F2N2O2/c17-13-4-2-10(6-14(13)18)16(21)20-12-3-1-9-5-11(19)8-22-15(9)7-12/h1-4,6-7,11H,5,8,19H2,(H,20,21)/t11-/m1/s1
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0.900n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390701
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3ccc4ccccc4c3)ccc2C1
Show InChI InChI=1S/C21H20N2O/c22-19-9-7-17-13-20(10-8-16(17)12-19)23-21(24)18-6-5-14-3-1-2-4-15(14)11-18/h1-6,8,10-11,13,19H,7,9,12,22H2,(H,23,24)/t19-/m0/s1
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1n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390718
PNG
((S)-1-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)Nc3ccc(Cl)cc3)ccc2C1
Show InChI InChI=1S/C17H18ClN3O/c18-13-3-7-15(8-4-13)20-17(22)21-16-6-2-11-9-14(19)5-1-12(11)10-16/h2-4,6-8,10,14H,1,5,9,19H2,(H2,20,21,22)/t14-/m0/s1
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Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390716
PNG
((S)-1-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)Nc3ccc(cc3)C3CC3)ccc2C1
Show InChI InChI=1S/C20H23N3O/c21-17-7-3-16-12-19(10-6-15(16)11-17)23-20(24)22-18-8-4-14(5-9-18)13-1-2-13/h4-6,8-10,12-13,17H,1-3,7,11,21H2,(H2,22,23,24)/t17-/m0/s1
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1n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390710
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES CCn1nc(C(=O)Nc2ccc3C[C@@H](N)CCc3c2)c(Br)c1OCC(F)F
Show InChI InChI=1S/C18H21BrF2N4O2/c1-2-25-18(27-9-14(20)21)15(19)16(24-25)17(26)23-13-6-4-10-7-12(22)5-3-11(10)8-13/h4,6,8,12,14H,2-3,5,7,9,22H2,1H3,(H,23,26)/t12-/m0/s1
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1.60n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390713
PNG
(6-Amino-N-(3-(trifluoromethoxy)phenyl)-5,6,7,8-tet...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H17F3N2O2/c19-18(20,21)25-16-3-1-2-15(10-16)23-17(24)13-5-4-12-9-14(22)7-6-11(12)8-13/h1-5,8,10,14H,6-7,9,22H2,(H,23,24)
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1.70n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390727
PNG
((R)-N-(3-Aminochroman-7-yl)-4-(2-methylthiazol-4-y...)
Show SMILES Cc1nc(cs1)-c1ccc(cc1)C(=O)Nc1ccc2C[C@@H](N)COc2c1
Show InChI InChI=1S/C20H19N3O2S/c1-12-22-18(11-26-12)13-2-4-14(5-3-13)20(24)23-17-7-6-15-8-16(21)10-25-19(15)9-17/h2-7,9,11,16H,8,10,21H2,1H3,(H,23,24)/t16-/m1/s1
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1.80n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390700
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3ccc(F)c(F)c3)ccc2C1
Show InChI InChI=1S/C17H16F2N2O/c18-15-6-3-12(9-16(15)19)17(22)21-14-5-2-10-7-13(20)4-1-11(10)8-14/h2-3,5-6,8-9,13H,1,4,7,20H2,(H,21,22)/t13-/m0/s1
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1.90n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390684
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES CCCc1cc(nn1CC(F)F)C(=O)Nc1ccc2C[C@@H](N)CCc2c1
Show InChI InChI=1S/C19H24F2N4O/c1-2-3-16-10-17(24-25(16)11-18(20)21)19(26)23-15-7-5-12-8-14(22)6-4-13(12)9-15/h5,7,9-10,14,18H,2-4,6,8,11,22H2,1H3,(H,23,26)/t14-/m0/s1
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2.10n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390696
PNG
((S)-N6-(5-(Trifluoromethyl)pyridin-2-yl)-1,2,3,4-t...)
Show SMILES N[C@H]1CCc2cc(Nc3ccc(cn3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C16H16F3N3/c17-16(18,19)12-3-6-15(21-9-12)22-14-5-2-10-7-13(20)4-1-11(10)8-14/h2-3,5-6,8-9,13H,1,4,7,20H2,(H,21,22)/t13-/m0/s1
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Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390704
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3cc(Cl)nc(Cl)c3)ccc2C1
Show InChI InChI=1S/C16H15Cl2N3O/c17-14-7-11(8-15(18)21-14)16(22)20-13-4-2-9-5-12(19)3-1-10(9)6-13/h2,4,6-8,12H,1,3,5,19H2,(H,20,22)/t12-/m0/s1
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2.20n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390736
PNG
((R)-N-(3-Aminochroman-7-yl)-4-bromo-5-(2,2-difluor...)
Show SMILES CCn1nc(C(=O)Nc2ccc3C[C@@H](N)COc3c2)c(Br)c1OCC(F)F
Show InChI InChI=1S/C17H19BrF2N4O3/c1-2-24-17(27-8-13(19)20)14(18)15(23-24)16(25)22-11-4-3-9-5-10(21)7-26-12(9)6-11/h3-4,6,10,13H,2,5,7-8,21H2,1H3,(H,22,25)/t10-/m1/s1
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2.30n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390730
PNG
((R)-N-(3-Aminochroman-7-yl)-4-cyano-3-fluorobenzam...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3ccc(C#N)c(F)c3)ccc2C1
Show InChI InChI=1S/C17H14FN3O2/c18-15-6-11(1-2-12(15)8-19)17(22)21-14-4-3-10-5-13(20)9-23-16(10)7-14/h1-4,6-7,13H,5,9,20H2,(H,21,22)/t13-/m1/s1
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2.60n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390713
PNG
(6-Amino-N-(3-(trifluoromethoxy)phenyl)-5,6,7,8-tet...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H17F3N2O2/c19-18(20,21)25-16-3-1-2-15(10-16)23-17(24)13-5-4-12-9-14(22)7-6-11(12)8-13/h1-5,8,10,14H,6-7,9,22H2,(H,23,24)
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3n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390699
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3cnc(Cl)c(Cl)c3)ccc2C1
Show InChI InChI=1S/C16H15Cl2N3O/c17-14-7-11(8-20-15(14)18)16(22)21-13-4-2-9-5-12(19)3-1-10(9)6-13/h2,4,6-8,12H,1,3,5,19H2,(H,21,22)/t12-/m0/s1
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3.10n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390699
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3cnc(Cl)c(Cl)c3)ccc2C1
Show InChI InChI=1S/C16H15Cl2N3O/c17-14-7-11(8-20-15(14)18)16(22)21-13-4-2-9-5-12(19)3-1-10(9)6-13/h2,4,6-8,12H,1,3,5,19H2,(H,21,22)/t12-/m0/s1
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3.10n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390696
PNG
((S)-N6-(5-(Trifluoromethyl)pyridin-2-yl)-1,2,3,4-t...)
Show SMILES N[C@H]1CCc2cc(Nc3ccc(cn3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C16H16F3N3/c17-16(18,19)12-3-6-15(21-9-12)22-14-5-2-10-7-13(20)4-1-11(10)8-14/h2-3,5-6,8-9,13H,1,4,7,20H2,(H,21,22)/t13-/m0/s1
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3.20n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390714
PNG
(6-Amino-N-(3-chlorophenyl)-5,6,7,8-tetrahydronapht...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C18H17N3O/c19-11-12-1-7-17(8-2-12)21-18(22)15-4-3-14-10-16(20)6-5-13(14)9-15/h1-4,7-9,16H,5-6,10,20H2,(H,21,22)
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3.20n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390727
PNG
((R)-N-(3-Aminochroman-7-yl)-4-(2-methylthiazol-4-y...)
Show SMILES Cc1nc(cs1)-c1ccc(cc1)C(=O)Nc1ccc2C[C@@H](N)COc2c1
Show InChI InChI=1S/C20H19N3O2S/c1-12-22-18(11-26-12)13-2-4-14(5-3-13)20(24)23-17-7-6-15-8-16(21)10-25-19(15)9-17/h2-7,9,11,16H,8,10,21H2,1H3,(H,23,24)/t16-/m1/s1
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3.40n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390735
PNG
((R)-N-(3-Aminochroman-7-yl)-2,6-dichloroisonicotin...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3cc(Cl)nc(Cl)c3)ccc2C1
Show InChI InChI=1S/C15H13Cl2N3O2/c16-13-4-9(5-14(17)20-13)15(21)19-11-2-1-8-3-10(18)7-22-12(8)6-11/h1-2,4-6,10H,3,7,18H2,(H,19,21)/t10-/m1/s1
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3.5n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390700
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3ccc(F)c(F)c3)ccc2C1
Show InChI InChI=1S/C17H16F2N2O/c18-15-6-3-12(9-16(15)19)17(22)21-14-5-2-10-7-13(20)4-1-11(10)8-14/h2-3,5-6,8-9,13H,1,4,7,20H2,(H,21,22)/t13-/m0/s1
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Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390682
PNG
(N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-1-(2...)
Show SMILES CCCc1cc(nn1CC(F)F)C(=O)Nc1ccc2CC(N)CCc2c1
Show InChI InChI=1S/C19H24F2N4O/c1-2-3-16-10-17(24-25(16)11-18(20)21)19(26)23-15-7-5-12-8-14(22)6-4-13(12)9-15/h5,7,9-10,14,18H,2-4,6,8,11,22H2,1H3,(H,23,26)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390692
PNG
(6-Amino-N-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetr...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H17F3N2O/c19-18(20,21)14-4-7-16(8-5-14)23-17(24)13-2-1-12-10-15(22)6-3-11(12)9-13/h1-2,4-5,7-9,15H,3,6,10,22H2,(H,23,24)
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3.90n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390681
PNG
(N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-4-br...)
Show SMILES NC1CCc2cc(NC(=O)c3n[nH]c(C4CC4)c3Br)ccc2C1
Show InChI InChI=1/C17H19BrN4O/c18-14-15(9-1-2-9)21-22-16(14)17(23)20-13-6-4-10-7-12(19)5-3-11(10)8-13/h4,6,8-9,12H,1-3,5,7,19H2,(H,20,23)(H,21,22)
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4.20n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390704
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3cc(Cl)nc(Cl)c3)ccc2C1
Show InChI InChI=1S/C16H15Cl2N3O/c17-14-7-11(8-15(18)21-14)16(22)20-13-4-2-9-5-12(19)3-1-10(9)6-13/h2,4,6-8,12H,1,3,5,19H2,(H,20,22)/t12-/m0/s1
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4.20n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390714
PNG
(6-Amino-N-(3-chlorophenyl)-5,6,7,8-tetrahydronapht...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1ccc(cc1)C#N
Show InChI InChI=1S/C18H17N3O/c19-11-12-1-7-17(8-2-12)21-18(22)15-4-3-14-10-16(20)6-5-13(14)9-15/h1-4,7-9,16H,5-6,10,20H2,(H,21,22)
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4.40n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390730
PNG
((R)-N-(3-Aminochroman-7-yl)-4-cyano-3-fluorobenzam...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3ccc(C#N)c(F)c3)ccc2C1
Show InChI InChI=1S/C17H14FN3O2/c18-15-6-11(1-2-12(15)8-19)17(22)21-14-4-3-10-5-13(20)9-23-16(10)7-14/h1-4,6-7,13H,5,9,20H2,(H,21,22)/t13-/m1/s1
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4.40n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390722
PNG
((R)-6-Amino-N-(3-(trifluoromethoxy)phenyl)-5,6,7,8...)
Show SMILES N[C@@H]1CCc2cc(ccc2C1)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H17F3N2O2/c19-18(20,21)25-16-3-1-2-15(10-16)23-17(24)13-5-4-12-9-14(22)7-6-11(12)8-13/h1-5,8,10,14H,6-7,9,22H2,(H,23,24)/t14-/m1/s1
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Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390709
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES CCc1n[nH]c(C(=O)Nc2ccc3C[C@@H](N)CCc3c2)c1C
Show InChI InChI=1/C17H22N4O/c1-3-15-10(2)16(21-20-15)17(22)19-14-7-5-11-8-13(18)6-4-12(11)9-14/h5,7,9,13H,3-4,6,8,18H2,1-2H3,(H,19,22)(H,20,21)/t13-/s2
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4.60n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390702
PNG
((S)-N6-(4-(Trifluoromethyl)phenyl)-1,2,3,4-tetrahy...)
Show SMILES N[C@H]1CCc2cc(Nc3ccc(cc3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C17H17F3N2/c18-17(19,20)13-3-7-15(8-4-13)22-16-6-2-11-9-14(21)5-1-12(11)10-16/h2-4,6-8,10,14,22H,1,5,9,21H2/t14-/m0/s1
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4.80n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390719
PNG
((S)-N6-(4-Chlorobenzyl)-1,2,3,4-tetrahydronaphthal...)
Show SMILES N[C@H]1CCc2cc(NCc3ccc(Cl)cc3)ccc2C1
Show InChI InChI=1S/C17H19ClN2/c18-15-5-1-12(2-6-15)11-20-17-8-4-13-9-16(19)7-3-14(13)10-17/h1-2,4-6,8,10,16,20H,3,7,9,11,19H2/t16-/m0/s1
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4.80n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390692
PNG
(6-Amino-N-(4-(trifluoromethyl)phenyl)-5,6,7,8-tetr...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C18H17F3N2O/c19-18(20,21)14-4-7-16(8-5-14)23-17(24)13-2-1-12-10-15(22)6-3-11(12)9-13/h1-2,4-5,7-9,15H,3,6,10,22H2,(H,23,24)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390693
PNG
(6-Amino-N-(4-(trifluoromethyl)benzyl)-5,6,7,8-tetr...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N2O/c20-19(21,22)16-6-1-12(2-7-16)11-24-18(25)15-4-3-14-10-17(23)8-5-13(14)9-15/h1-4,6-7,9,17H,5,8,10-11,23H2,(H,24,25)
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Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390683
PNG
((R)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES CCCc1cc(nn1CC(F)F)C(=O)Nc1ccc2C[C@H](N)CCc2c1
Show InChI InChI=1S/C19H24F2N4O/c1-2-3-16-10-17(24-25(16)11-18(20)21)19(26)23-15-7-5-12-8-14(22)6-4-13(12)9-15/h5,7,9-10,14,18H,2-4,6,8,11,22H2,1H3,(H,23,26)/t14-/m1/s1
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Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390711
PNG
((S)-N6-(4-Ethylphenyl)-1,2,3,4-tetrahydronaphthale...)
Show SMILES CCc1ccc(Nc2ccc3C[C@@H](N)CCc3c2)cc1
Show InChI InChI=1S/C18H22N2/c1-2-13-3-8-17(9-4-13)20-18-10-6-14-11-16(19)7-5-15(14)12-18/h3-4,6,8-10,12,16,20H,2,5,7,11,19H2,1H3/t16-/m0/s1
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6n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390729
PNG
((R)-N-(3-Aminochroman-7-yl)-1-methyl-5-(thiophen-2...)
Show SMILES Cn1nc(cc1-c1cccs1)C(=O)Nc1ccc2C[C@@H](N)COc2c1
Show InChI InChI=1S/C18H18N4O2S/c1-22-15(17-3-2-6-25-17)9-14(21-22)18(23)20-13-5-4-11-7-12(19)10-24-16(11)8-13/h2-6,8-9,12H,7,10,19H2,1H3,(H,20,23)/t12-/m1/s1
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Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390709
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES CCc1n[nH]c(C(=O)Nc2ccc3C[C@@H](N)CCc3c2)c1C
Show InChI InChI=1/C17H22N4O/c1-3-15-10(2)16(21-20-15)17(22)19-14-7-5-11-8-13(18)6-4-12(11)9-14/h5,7,9,13H,3-4,6,8,18H2,1-2H3,(H,19,22)(H,20,21)/t13-/s2
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6.20n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390703
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3ccnc(c3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C17H16F3N3O/c18-17(19,20)15-9-12(5-6-22-15)16(24)23-14-4-2-10-7-13(21)3-1-11(10)8-14/h2,4-6,8-9,13H,1,3,7,21H2,(H,23,24)/t13-/m0/s1
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6.30n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390684
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES CCCc1cc(nn1CC(F)F)C(=O)Nc1ccc2C[C@@H](N)CCc2c1
Show InChI InChI=1S/C19H24F2N4O/c1-2-3-16-10-17(24-25(16)11-18(20)21)19(26)23-15-7-5-12-8-14(22)6-4-13(12)9-15/h5,7,9-10,14,18H,2-4,6,8,11,22H2,1H3,(H,23,26)/t14-/m0/s1
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6.70n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390680
PNG
(N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-2-(t...)
Show SMILES NC1CCc2cc(NC(=O)c3ccnc(c3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C17H16F3N3O/c18-17(19,20)15-9-12(5-6-22-15)16(24)23-14-4-2-10-7-13(21)3-1-11(10)8-14/h2,4-6,8-9,13H,1,3,7,21H2,(H,23,24)
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7.20n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390722
PNG
((R)-6-Amino-N-(3-(trifluoromethoxy)phenyl)-5,6,7,8...)
Show SMILES N[C@@H]1CCc2cc(ccc2C1)C(=O)Nc1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C18H17F3N2O2/c19-18(20,21)25-16-3-1-2-15(10-16)23-17(24)13-5-4-12-9-14(22)7-6-11(12)8-13/h1-5,8,10,14H,6-7,9,22H2,(H,23,24)/t14-/m1/s1
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7.30n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390735
PNG
((R)-N-(3-Aminochroman-7-yl)-2,6-dichloroisonicotin...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3cc(Cl)nc(Cl)c3)ccc2C1
Show InChI InChI=1S/C15H13Cl2N3O2/c16-13-4-9(5-14(17)20-13)15(21)19-11-2-1-8-3-10(18)7-22-12(8)6-11/h1-2,4-6,10H,3,7,18H2,(H,19,21)/t10-/m1/s1
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7.70n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390681
PNG
(N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-4-br...)
Show SMILES NC1CCc2cc(NC(=O)c3n[nH]c(C4CC4)c3Br)ccc2C1
Show InChI InChI=1/C17H19BrN4O/c18-14-15(9-1-2-9)21-22-16(14)17(23)20-13-6-4-10-7-12(19)5-3-11(10)8-13/h4,6,8-9,12H,1-3,5,7,19H2,(H,20,23)(H,21,22)
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7.70n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390717
PNG
((S)-N6-(4-Cyclopropylphenyl)-1,2,3,4-tetrahydronap...)
Show SMILES N[C@H]1CCc2cc(Nc3ccc(cc3)C3CC3)ccc2C1
Show InChI InChI=1S/C19H22N2/c20-17-7-3-16-12-19(10-6-15(16)11-17)21-18-8-4-14(5-9-18)13-1-2-13/h4-6,8-10,12-13,17,21H,1-3,7,11,20H2/t17-/m0/s1
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8.10n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390725
PNG
((R)-N-(3-Aminochroman-7-yl)-5-ethoxy-4-methyl-1H-p...)
Show SMILES CCOc1[nH]nc(C(=O)Nc2ccc3C[C@@H](N)COc3c2)c1C
Show InChI InChI=1/C16H20N4O3/c1-3-22-16-9(2)14(19-20-16)15(21)18-12-5-4-10-6-11(17)8-23-13(10)7-12/h4-5,7,11H,3,6,8,17H2,1-2H3,(H,18,21)(H,19,20)/t11-/s2
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8.20n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390711
PNG
((S)-N6-(4-Ethylphenyl)-1,2,3,4-tetrahydronaphthale...)
Show SMILES CCc1ccc(Nc2ccc3C[C@@H](N)CCc3c2)cc1
Show InChI InChI=1S/C18H22N2/c1-2-13-3-8-17(9-4-13)20-18-10-6-14-11-16(19)7-5-15(14)12-18/h3-4,6,8-10,12,16,20H,2,5,7,11,19H2,1H3/t16-/m0/s1
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8.30n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390732
PNG
((R)-N-(3-Aminochroman-7-yl)-3-ethyl-4-methyl-1H-py...)
Show SMILES CCc1n[nH]c(C(=O)Nc2ccc3C[C@@H](N)COc3c2)c1C
Show InChI InChI=1/C16H20N4O2/c1-3-13-9(2)15(20-19-13)16(21)18-12-5-4-10-6-11(17)8-22-14(10)7-12/h4-5,7,11H,3,6,8,17H2,1-2H3,(H,18,21)(H,19,20)/t11-/s2
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8.30n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390733
PNG
((R)-N-(3-Aminochroman-7-yl)-2-chloro-6-methylisoni...)
Show SMILES Cc1cc(cc(Cl)n1)C(=O)Nc1ccc2C[C@@H](N)COc2c1
Show InChI InChI=1S/C16H16ClN3O2/c1-9-4-11(6-15(17)19-9)16(21)20-13-3-2-10-5-12(18)8-22-14(10)7-13/h2-4,6-7,12H,5,8,18H2,1H3,(H,20,21)/t12-/m1/s1
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8.80n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390734
PNG
((R)-N-(3-Aminochroman-7-yl)-2-(trifluoromethyl)iso...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3ccnc(c3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C16H14F3N3O2/c17-16(18,19)14-6-10(3-4-21-14)15(23)22-12-2-1-9-5-11(20)8-24-13(9)7-12/h1-4,6-7,11H,5,8,20H2,(H,22,23)/t11-/m1/s1
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9.10n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390734
PNG
((R)-N-(3-Aminochroman-7-yl)-2-(trifluoromethyl)iso...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3ccnc(c3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C16H14F3N3O2/c17-16(18,19)14-6-10(3-4-21-14)15(23)22-12-2-1-9-5-11(20)8-24-13(9)7-12/h1-4,6-7,11H,5,8,20H2,(H,22,23)/t11-/m1/s1
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9.60n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390717
PNG
((S)-N6-(4-Cyclopropylphenyl)-1,2,3,4-tetrahydronap...)
Show SMILES N[C@H]1CCc2cc(Nc3ccc(cc3)C3CC3)ccc2C1
Show InChI InChI=1S/C19H22N2/c20-17-7-3-16-12-19(10-6-15(16)11-17)21-18-8-4-14(5-9-18)13-1-2-13/h4-6,8-10,12-13,17,21H,1-3,7,11,20H2/t17-/m0/s1
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10n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390687
PNG
(N-(3-Aminochroman-7-yl)-1-(2,2-difluoroethyl)-5-pr...)
Show SMILES CCCc1cc(nn1CC(F)F)C(=O)Nc1ccc2CC(N)COc2c1
Show InChI InChI=1S/C18H22F2N4O2/c1-2-3-14-8-15(23-24(14)9-17(19)20)18(25)22-13-5-4-11-6-12(21)10-26-16(11)7-13/h4-5,7-8,12,17H,2-3,6,9-10,21H2,1H3,(H,22,25)
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10n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390712
PNG
(6-Amino-N-(3-methoxyphenyl)-5,6,7,8-tetrahydronaph...)
Show SMILES COc1cccc(NC(=O)c2ccc3CC(N)CCc3c2)c1
Show InChI InChI=1S/C18H20N2O2/c1-22-17-4-2-3-16(11-17)20-18(21)14-6-5-13-10-15(19)8-7-12(13)9-14/h2-6,9,11,15H,7-8,10,19H2,1H3,(H,20,21)
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10.7n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390708
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES Cc1cc(cc(Cl)n1)C(=O)Nc1ccc2C[C@@H](N)CCc2c1
Show InChI InChI=1S/C17H18ClN3O/c1-10-6-13(9-16(18)20-10)17(22)21-15-5-3-11-7-14(19)4-2-12(11)8-15/h3,5-6,8-9,14H,2,4,7,19H2,1H3,(H,21,22)/t14-/m0/s1
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10.8n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390702
PNG
((S)-N6-(4-(Trifluoromethyl)phenyl)-1,2,3,4-tetrahy...)
Show SMILES N[C@H]1CCc2cc(Nc3ccc(cc3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C17H17F3N2/c18-17(19,20)13-3-7-15(8-4-13)22-16-6-2-11-9-14(21)5-1-12(11)10-16/h2-4,6-8,10,14,22H,1,5,9,21H2/t14-/m0/s1
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11.3n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390703
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3ccnc(c3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C17H16F3N3O/c18-17(19,20)15-9-12(5-6-22-15)16(24)23-14-4-2-10-7-13(21)3-1-11(10)8-14/h2,4-6,8-9,13H,1,3,7,21H2,(H,23,24)/t13-/m0/s1
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11.7n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390732
PNG
((R)-N-(3-Aminochroman-7-yl)-3-ethyl-4-methyl-1H-py...)
Show SMILES CCc1n[nH]c(C(=O)Nc2ccc3C[C@@H](N)COc3c2)c1C
Show InChI InChI=1/C16H20N4O2/c1-3-13-9(2)15(20-19-13)16(21)18-12-5-4-10-6-11(17)8-22-14(10)7-12/h4-5,7,11H,3,6,8,17H2,1-2H3,(H,18,21)(H,19,20)/t11-/s2
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11.9n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390710
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES CCn1nc(C(=O)Nc2ccc3C[C@@H](N)CCc3c2)c(Br)c1OCC(F)F
Show InChI InChI=1S/C18H21BrF2N4O2/c1-2-25-18(27-9-14(20)21)15(19)16(24-25)17(26)23-13-6-4-10-7-12(22)5-3-11(10)8-13/h4,6,8,12,14H,2-3,5,7,9,22H2,1H3,(H,23,26)/t12-/m0/s1
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12.8n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390682
PNG
(N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-1-(2...)
Show SMILES CCCc1cc(nn1CC(F)F)C(=O)Nc1ccc2CC(N)CCc2c1
Show InChI InChI=1S/C19H24F2N4O/c1-2-3-16-10-17(24-25(16)11-18(20)21)19(26)23-15-7-5-12-8-14(22)6-4-13(12)9-15/h5,7,9-10,14,18H,2-4,6,8,11,22H2,1H3,(H,23,26)
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13.2n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390706
PNG
((S)-N6-(4-Chlorophenyl)-1,2,3,4-tetrahydronaphthal...)
Show SMILES N[C@H]1CCc2cc(Nc3ccc(Cl)cc3)ccc2C1
Show InChI InChI=1S/C16H17ClN2/c17-13-3-7-15(8-4-13)19-16-6-2-11-9-14(18)5-1-12(11)10-16/h2-4,6-8,10,14,19H,1,5,9,18H2/t14-/m0/s1
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13.9n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390707
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3cncc(Cl)c3)ccc2C1
Show InChI InChI=1S/C16H16ClN3O/c17-13-5-12(8-19-9-13)16(21)20-15-4-2-10-6-14(18)3-1-11(10)7-15/h2,4-5,7-9,14H,1,3,6,18H2,(H,20,21)/t14-/m0/s1
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14.4n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390708
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES Cc1cc(cc(Cl)n1)C(=O)Nc1ccc2C[C@@H](N)CCc2c1
Show InChI InChI=1S/C17H18ClN3O/c1-10-6-13(9-16(18)20-10)17(22)21-15-5-3-11-7-14(19)4-2-12(11)8-15/h3,5-6,8-9,14H,2,4,7,19H2,1H3,(H,21,22)/t14-/m0/s1
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14.7n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390736
PNG
((R)-N-(3-Aminochroman-7-yl)-4-bromo-5-(2,2-difluor...)
Show SMILES CCn1nc(C(=O)Nc2ccc3C[C@@H](N)COc3c2)c(Br)c1OCC(F)F
Show InChI InChI=1S/C17H19BrF2N4O3/c1-2-24-17(27-8-13(19)20)14(18)15(23-24)16(25)22-11-4-3-9-5-10(21)7-26-12(9)6-11/h3-4,6,10,13H,2,5,7-8,21H2,1H3,(H,22,25)/t10-/m1/s1
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15.1n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390719
PNG
((S)-N6-(4-Chlorobenzyl)-1,2,3,4-tetrahydronaphthal...)
Show SMILES N[C@H]1CCc2cc(NCc3ccc(Cl)cc3)ccc2C1
Show InChI InChI=1S/C17H19ClN2/c18-15-5-1-12(2-6-15)11-20-17-8-4-13-9-16(19)7-3-14(13)10-17/h1-2,4-6,8,10,16,20H,3,7,9,11,19H2/t16-/m0/s1
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15.3n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390680
PNG
(N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-2-(t...)
Show SMILES NC1CCc2cc(NC(=O)c3ccnc(c3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C17H16F3N3O/c18-17(19,20)15-9-12(5-6-22-15)16(24)23-14-4-2-10-7-13(21)3-1-11(10)8-14/h2,4-6,8-9,13H,1,3,7,21H2,(H,23,24)
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15.9n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390724
PNG
((R)-N7-(5-(Trifluoromethyl)pyrimidin-2-yl)chroman-...)
Show SMILES N[C@H]1COc2cc(Nc3ncc(cn3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C14H13F3N4O/c15-14(16,17)9-5-19-13(20-6-9)21-11-2-1-8-3-10(18)7-22-12(8)4-11/h1-2,4-6,10H,3,7,18H2,(H,19,20,21)/t10-/m1/s1
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16.3n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390698
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3ccc(Cl)nc3)ccc2C1
Show InChI InChI=1S/C16H16ClN3O/c17-15-6-3-12(9-19-15)16(21)20-14-5-2-10-7-13(18)4-1-11(10)8-14/h2-3,5-6,8-9,13H,1,4,7,18H2,(H,20,21)/t13-/m0/s1
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16.5n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390698
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3ccc(Cl)nc3)ccc2C1
Show InChI InChI=1S/C16H16ClN3O/c17-15-6-3-12(9-19-15)16(21)20-14-5-2-10-7-13(18)4-1-11(10)8-14/h2-3,5-6,8-9,13H,1,4,7,18H2,(H,20,21)/t13-/m0/s1
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17.2n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390731
PNG
((R)-N-(3-Aminochroman-7-yl)-3,4-difluorobenzamide ...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3ccc(F)c(F)c3)ccc2C1
Show InChI InChI=1S/C16H14F2N2O2/c17-13-4-2-10(6-14(13)18)16(21)20-12-3-1-9-5-11(19)8-22-15(9)7-12/h1-4,6-7,11H,5,8,19H2,(H,20,21)/t11-/m1/s1
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18.9n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390688
PNG
((S)-N6-(5-Chloropyrimidin-2-yl)-1,2,3,4-tetrahydro...)
Show SMILES N[C@H]1CCc2cc(Nc3ncc(Cl)cn3)ccc2C1
Show InChI InChI=1S/C14H15ClN4/c15-11-7-17-14(18-8-11)19-13-4-2-9-5-12(16)3-1-10(9)6-13/h2,4,6-8,12H,1,3,5,16H2,(H,17,18,19)/t12-/m0/s1
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19.1n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390724
PNG
((R)-N7-(5-(Trifluoromethyl)pyrimidin-2-yl)chroman-...)
Show SMILES N[C@H]1COc2cc(Nc3ncc(cn3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C14H13F3N4O/c15-14(16,17)9-5-19-13(20-6-9)21-11-2-1-8-3-10(18)7-22-12(8)4-11/h1-2,4-6,10H,3,7,18H2,(H,19,20,21)/t10-/m1/s1
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19.6n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390686
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES Cc1cc(nc(n1)C(F)(F)F)C(=O)Nc1ccc2C[C@@H](N)CCc2c1
Show InChI InChI=1S/C17H17F3N4O/c1-9-6-14(24-16(22-9)17(18,19)20)15(25)23-13-5-3-10-7-12(21)4-2-11(10)8-13/h3,5-6,8,12H,2,4,7,21H2,1H3,(H,23,25)/t12-/m0/s1
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19.8n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390687
PNG
(N-(3-Aminochroman-7-yl)-1-(2,2-difluoroethyl)-5-pr...)
Show SMILES CCCc1cc(nn1CC(F)F)C(=O)Nc1ccc2CC(N)COc2c1
Show InChI InChI=1S/C18H22F2N4O2/c1-2-3-14-8-15(23-24(14)9-17(19)20)18(25)22-13-5-4-11-6-12(21)10-26-16(11)7-13/h4-5,7-8,12,17H,2-3,6,9-10,21H2,1H3,(H,22,25)
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19.8n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390715
PNG
((S)-1-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)Nc3ccc(cc3)C#N)ccc2C1
Show InChI InChI=1S/C18H18N4O/c19-11-12-1-6-16(7-2-12)21-18(23)22-17-8-4-13-9-15(20)5-3-14(13)10-17/h1-2,4,6-8,10,15H,3,5,9,20H2,(H2,21,22,23)/t15-/m0/s1
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20.6n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390691
PNG
(6-Amino-N-(5-(trifluoromethyl)pyrazin-2-yl)-5,6,7,...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)13-7-22-14(8-21-13)23-15(24)11-2-1-10-6-12(20)4-3-9(10)5-11/h1-2,5,7-8,12H,3-4,6,20H2,(H,22,23,24)
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21n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390706
PNG
((S)-N6-(4-Chlorophenyl)-1,2,3,4-tetrahydronaphthal...)
Show SMILES N[C@H]1CCc2cc(Nc3ccc(Cl)cc3)ccc2C1
Show InChI InChI=1S/C16H17ClN2/c17-13-3-7-15(8-4-13)19-16-6-2-11-9-14(18)5-1-12(11)10-16/h2-4,6-8,10,14,19H,1,5,9,18H2/t14-/m0/s1
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23.2n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390707
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3cncc(Cl)c3)ccc2C1
Show InChI InChI=1S/C16H16ClN3O/c17-13-5-12(8-19-9-13)16(21)20-15-4-2-10-6-14(18)3-1-11(10)7-15/h2,4-5,7-9,14H,1,3,6,18H2,(H,20,21)/t14-/m0/s1
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23.5n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390733
PNG
((R)-N-(3-Aminochroman-7-yl)-2-chloro-6-methylisoni...)
Show SMILES Cc1cc(cc(Cl)n1)C(=O)Nc1ccc2C[C@@H](N)COc2c1
Show InChI InChI=1S/C16H16ClN3O2/c1-9-4-11(6-15(17)19-9)16(21)20-13-3-2-10-5-12(18)8-22-14(10)7-13/h2-4,6-7,12H,5,8,18H2,1H3,(H,20,21)/t12-/m1/s1
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24.3n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390689
PNG
(6-Amino-N-(6-ethoxypyridin-3-yl)-5,6,7,8-tetrahydr...)
Show SMILES CCOc1ccc(NC(=O)c2ccc3CC(N)CCc3c2)cn1
Show InChI InChI=1S/C18H21N3O2/c1-2-23-17-8-7-16(11-20-17)21-18(22)14-4-3-13-10-15(19)6-5-12(13)9-14/h3-4,7-9,11,15H,2,5-6,10,19H2,1H3,(H,21,22)
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24.7n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390715
PNG
((S)-1-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)Nc3ccc(cc3)C#N)ccc2C1
Show InChI InChI=1S/C18H18N4O/c19-11-12-1-6-16(7-2-12)21-18(23)22-17-8-4-13-9-15(20)5-3-14(13)10-17/h1-2,4,6-8,10,15H,3,5,9,20H2,(H2,21,22,23)/t15-/m0/s1
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25.8n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390725
PNG
((R)-N-(3-Aminochroman-7-yl)-5-ethoxy-4-methyl-1H-p...)
Show SMILES CCOc1[nH]nc(C(=O)Nc2ccc3C[C@@H](N)COc3c2)c1C
Show InChI InChI=1/C16H20N4O3/c1-3-22-16-9(2)14(19-20-16)15(21)18-12-5-4-10-6-11(17)8-23-13(10)7-12/h4-5,7,11H,3,6,8,17H2,1-2H3,(H,18,21)(H,19,20)/t11-/s2
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27.7n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390686
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES Cc1cc(nc(n1)C(F)(F)F)C(=O)Nc1ccc2C[C@@H](N)CCc2c1
Show InChI InChI=1S/C17H17F3N4O/c1-9-6-14(24-16(22-9)17(18,19)20)15(25)23-13-5-3-10-7-12(21)4-2-11(10)8-13/h3,5-6,8,12H,2,4,7,21H2,1H3,(H,23,25)/t12-/m0/s1
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31.8n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390694
PNG
(6-Amino-N-((6-chloropyridin-3-yl)methyl)-5,6,7,8-t...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)NCc1ccc(Cl)nc1
Show InChI InChI=1S/C17H18ClN3O/c18-16-6-1-11(9-20-16)10-21-17(22)14-3-2-13-8-15(19)5-4-12(13)7-14/h1-3,6-7,9,15H,4-5,8,10,19H2,(H,21,22)
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31.8n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390693
PNG
(6-Amino-N-(4-(trifluoromethyl)benzyl)-5,6,7,8-tetr...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)NCc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C19H19F3N2O/c20-19(21,22)16-6-1-12(2-7-16)11-24-18(25)15-4-3-14-10-17(23)8-5-13(14)9-15/h1-4,6-7,9,17H,5,8,10-11,23H2,(H,24,25)
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35n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390695
PNG
(6-Amino-N-(6-chloropyridin-3-yl)-5,6,7,8-tetrahydr...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1ccc(Cl)nc1
Show InChI InChI=1S/C16H16ClN3O/c17-15-6-5-14(9-19-15)20-16(21)12-2-1-11-8-13(18)4-3-10(11)7-12/h1-2,5-7,9,13H,3-4,8,18H2,(H,20,21)
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35.6n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390728
PNG
((R)-N-(3-Aminochroman-7-yl)-5-(trifluoromethyl)pyr...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3ncc(cn3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C15H13F3N4O2/c16-15(17,18)9-5-20-13(21-6-9)14(23)22-11-2-1-8-3-10(19)7-24-12(8)4-11/h1-2,4-6,10H,3,7,19H2,(H,22,23)/t10-/m1/s1
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37.1n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390737
PNG
((R)-N7-(5-Chloropyrimidin-2-yl)chroman-3,7-diamine...)
Show SMILES N[C@H]1COc2cc(Nc3ncc(Cl)cn3)ccc2C1
Show InChI InChI=1S/C13H13ClN4O/c14-9-5-16-13(17-6-9)18-11-2-1-8-3-10(15)7-19-12(8)4-11/h1-2,4-6,10H,3,7,15H2,(H,16,17,18)/t10-/m1/s1
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37.4n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390737
PNG
((R)-N7-(5-Chloropyrimidin-2-yl)chroman-3,7-diamine...)
Show SMILES N[C@H]1COc2cc(Nc3ncc(Cl)cn3)ccc2C1
Show InChI InChI=1S/C13H13ClN4O/c14-9-5-16-13(17-6-9)18-11-2-1-8-3-10(15)7-19-12(8)4-11/h1-2,4-6,10H,3,7,15H2,(H,16,17,18)/t10-/m1/s1
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42n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390689
PNG
(6-Amino-N-(6-ethoxypyridin-3-yl)-5,6,7,8-tetrahydr...)
Show SMILES CCOc1ccc(NC(=O)c2ccc3CC(N)CCc3c2)cn1
Show InChI InChI=1S/C18H21N3O2/c1-2-23-17-8-7-16(11-20-17)21-18(22)14-4-3-13-10-15(19)6-5-12(13)9-14/h3-4,7-9,11,15H,2,5-6,10,19H2,1H3,(H,21,22)
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43.4n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390738
PNG
((S)-N6-(3-Methoxyphenyl)-1,2,3,4-tetrahydronaphtha...)
Show SMILES COc1cccc(Nc2ccc3C[C@@H](N)COc3c2)c1
Show InChI InChI=1S/C16H18N2O2/c1-19-15-4-2-3-13(8-15)18-14-6-5-11-7-12(17)10-20-16(11)9-14/h2-6,8-9,12,18H,7,10,17H2,1H3/t12-/m1/s1
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46.2n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390705
PNG
((S)-4-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-ylam...)
Show SMILES N[C@H]1CCc2cc(Nc3ccc(cc3)C#N)ccc2C1
Show InChI InChI=1S/C17H17N3/c18-11-12-1-6-16(7-2-12)20-17-8-4-13-9-15(19)5-3-14(13)10-17/h1-2,4,6-8,10,15,20H,3,5,9,19H2/t15-/m0/s1
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50.5n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390738
PNG
((S)-N6-(3-Methoxyphenyl)-1,2,3,4-tetrahydronaphtha...)
Show SMILES COc1cccc(Nc2ccc3C[C@@H](N)COc3c2)c1
Show InChI InChI=1S/C16H18N2O2/c1-19-15-4-2-3-13(8-15)18-14-6-5-11-7-12(17)10-20-16(11)9-14/h2-6,8-9,12,18H,7,10,17H2,1H3/t12-/m1/s1
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54.1n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390685
PNG
((R)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES Cc1cc(nc(n1)C(F)(F)F)C(=O)Nc1ccc2C[C@H](N)CCc2c1
Show InChI InChI=1S/C17H17F3N4O/c1-9-6-14(24-16(22-9)17(18,19)20)15(25)23-13-5-3-10-7-12(21)4-2-11(10)8-13/h3,5-6,8,12H,2,4,7,21H2,1H3,(H,23,25)/t12-/m1/s1
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54.4n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390688
PNG
((S)-N6-(5-Chloropyrimidin-2-yl)-1,2,3,4-tetrahydro...)
Show SMILES N[C@H]1CCc2cc(Nc3ncc(Cl)cn3)ccc2C1
Show InChI InChI=1S/C14H15ClN4/c15-11-7-17-14(18-8-11)19-13-4-2-9-5-12(16)3-1-10(9)6-13/h2,4,6-8,12H,1,3,5,16H2,(H,17,18,19)/t12-/m0/s1
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70.9n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390721
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc2C1
Show InChI InChI=1S/C16H17ClN2O2S/c17-13-3-7-16(8-4-13)22(20,21)19-15-6-2-11-9-14(18)5-1-12(11)10-15/h2-4,6-8,10,14,19H,1,5,9,18H2/t14-/m0/s1
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75.5n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390728
PNG
((R)-N-(3-Aminochroman-7-yl)-5-(trifluoromethyl)pyr...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3ncc(cn3)C(F)(F)F)ccc2C1
Show InChI InChI=1S/C15H13F3N4O2/c16-15(17,18)9-5-20-13(21-6-9)14(23)22-11-2-1-8-3-10(19)7-24-12(8)4-11/h1-2,4-6,10H,3,7,19H2,(H,22,23)/t10-/m1/s1
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75.8n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390691
PNG
(6-Amino-N-(5-(trifluoromethyl)pyrazin-2-yl)-5,6,7,...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1cnc(cn1)C(F)(F)F
Show InChI InChI=1S/C16H15F3N4O/c17-16(18,19)13-7-22-14(8-21-13)23-15(24)11-2-1-10-6-12(20)4-3-9(10)5-11/h1-2,5,7-8,12H,3-4,6,20H2,(H,22,23,24)
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86.5n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390694
PNG
(6-Amino-N-((6-chloropyridin-3-yl)methyl)-5,6,7,8-t...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)NCc1ccc(Cl)nc1
Show InChI InChI=1S/C17H18ClN3O/c18-16-6-1-11(9-20-16)10-21-17(22)14-3-2-13-8-15(19)5-4-12(13)7-14/h1-3,6-7,9,15H,4-5,8,10,19H2,(H,21,22)
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89.8n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390695
PNG
(6-Amino-N-(6-chloropyridin-3-yl)-5,6,7,8-tetrahydr...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1ccc(Cl)nc1
Show InChI InChI=1S/C16H16ClN3O/c17-15-6-5-14(9-19-15)20-16(21)12-2-1-11-8-13(18)4-3-10(11)7-12/h1-2,5-7,9,13H,3-4,8,18H2,(H,20,21)
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90.4n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390712
PNG
(6-Amino-N-(3-methoxyphenyl)-5,6,7,8-tetrahydronaph...)
Show SMILES COc1cccc(NC(=O)c2ccc3CC(N)CCc3c2)c1
Show InChI InChI=1S/C18H20N2O2/c1-22-17-4-2-3-16(11-17)20-18(21)14-6-5-13-10-15(19)8-7-12(13)9-14/h2-6,9,11,15H,7-8,10,19H2,1H3,(H,20,21)
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91n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390683
PNG
((R)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES CCCc1cc(nn1CC(F)F)C(=O)Nc1ccc2C[C@H](N)CCc2c1
Show InChI InChI=1S/C19H24F2N4O/c1-2-3-16-10-17(24-25(16)11-18(20)21)19(26)23-15-7-5-12-8-14(22)6-4-13(12)9-15/h5,7,9-10,14,18H,2-4,6,8,11,22H2,1H3,(H,23,26)/t14-/m1/s1
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91.4n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390690
PNG
(6-Amino-N-(2-cyclopropylpyrimidin-5-yl)-5,6,7,8-te...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1cnc(nc1)C1CC1
Show InChI InChI=1S/C18H20N4O/c19-15-6-5-12-7-14(4-3-13(12)8-15)18(23)22-16-9-20-17(21-10-16)11-1-2-11/h3-4,7,9-11,15H,1-2,5-6,8,19H2,(H,22,23)
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105n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390705
PNG
((S)-4-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-ylam...)
Show SMILES N[C@H]1CCc2cc(Nc3ccc(cc3)C#N)ccc2C1
Show InChI InChI=1S/C17H17N3/c18-11-12-1-6-16(7-2-12)20-17-8-4-13-9-15(19)5-3-14(13)10-17/h1-2,4,6-8,10,15,20H,3,5,9,19H2/t15-/m0/s1
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116n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390697
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3cccnc3F)ccc2C1
Show InChI InChI=1S/C16H16FN3O/c17-15-14(2-1-7-19-15)16(21)20-13-6-4-10-8-12(18)5-3-11(10)9-13/h1-2,4,6-7,9,12H,3,5,8,18H2,(H,20,21)/t12-/m0/s1
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140n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390726
PNG
((R)-N-(3-Aminochroman-7-yl)-4-chloropyrimidine-2-c...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3nccc(Cl)n3)ccc2C1
Show InChI InChI=1S/C14H13ClN4O2/c15-12-3-4-17-13(19-12)14(20)18-10-2-1-8-5-9(16)7-21-11(8)6-10/h1-4,6,9H,5,7,16H2,(H,18,20)/t9-/m1/s1
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173n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390685
PNG
((R)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES Cc1cc(nc(n1)C(F)(F)F)C(=O)Nc1ccc2C[C@H](N)CCc2c1
Show InChI InChI=1S/C17H17F3N4O/c1-9-6-14(24-16(22-9)17(18,19)20)15(25)23-13-5-3-10-7-12(21)4-2-11(10)8-13/h3,5-6,8,12H,2,4,7,21H2,1H3,(H,23,25)/t12-/m1/s1
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232n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390721
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NS(=O)(=O)c3ccc(Cl)cc3)ccc2C1
Show InChI InChI=1S/C16H17ClN2O2S/c17-13-3-7-16(8-4-13)22(20,21)19-15-6-2-11-9-14(18)5-1-12(11)10-15/h2-4,6-8,10,14,19H,1,5,9,18H2/t14-/m0/s1
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264n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390720
PNG
((S)-N-(6-Amino-1-chloro-5,6,7,8-tetrahydronaphthal...)
Show SMILES N[C@H]1CCc2c(C1)ccc(NC(=O)c1ccc(Cl)nc1)c2Cl
Show InChI InChI=1S/C16H15Cl2N3O/c17-14-6-2-10(8-20-14)16(22)21-13-5-1-9-7-11(19)3-4-12(9)15(13)18/h1-2,5-6,8,11H,3-4,7,19H2,(H,21,22)/t11-/m0/s1
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302n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390690
PNG
(6-Amino-N-(2-cyclopropylpyrimidin-5-yl)-5,6,7,8-te...)
Show SMILES NC1CCc2cc(ccc2C1)C(=O)Nc1cnc(nc1)C1CC1
Show InChI InChI=1S/C18H20N4O/c19-15-6-5-12-7-14(4-3-13(12)8-15)18(23)22-16-9-20-17(21-10-16)11-1-2-11/h3-4,7,9-11,15H,1-2,5-6,8,19H2,(H,22,23)
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309n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390697
PNG
((S)-N-(6-Amino-5,6,7,8-tetrahydronaphthalen-2-yl)-...)
Show SMILES N[C@H]1CCc2cc(NC(=O)c3cccnc3F)ccc2C1
Show InChI InChI=1S/C16H16FN3O/c17-15-14(2-1-7-19-15)16(21)20-13-6-4-10-8-12(18)5-3-11(10)9-13/h1-2,4,6-7,9,12H,3,5,8,18H2,(H,20,21)/t12-/m0/s1
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476n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1


(Rattus norvegicus (Rat))
BDBM390726
PNG
((R)-N-(3-Aminochroman-7-yl)-4-chloropyrimidine-2-c...)
Show SMILES N[C@H]1COc2cc(NC(=O)c3nccc(Cl)n3)ccc2C1
Show InChI InChI=1S/C14H13ClN4O2/c15-12-3-4-17-13(19-12)14(20)18-10-2-1-8-5-9(16)7-21-11(8)6-10/h1-4,6,9H,5,7,16H2,(H,18,20)/t9-/m1/s1
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511n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Mouse:HEK-293 cells stably expressing mouse TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%,...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
Trace amine-associated receptor 1 (TAAR1)


(Mus musculus (Mouse))
BDBM390720
PNG
((S)-N-(6-Amino-1-chloro-5,6,7,8-tetrahydronaphthal...)
Show SMILES N[C@H]1CCc2c(C1)ccc(NC(=O)c1ccc(Cl)nc1)c2Cl
Show InChI InChI=1S/C16H15Cl2N3O/c17-14-6-2-10(8-20-14)16(22)21-13-5-1-9-7-11(19)3-4-12(9)15(13)18/h1-2,5-6,8,11H,3-4,7,19H2,(H,21,22)/t11-/m0/s1
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>1.51E+3n/an/an/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Rat:HEK-293 cells stably expressing rat TAAR1 were maintained at 37 C. and 5% CO2 in DMEM high glucose medium, containing fetal calf serum (10%, hea...


US Patent US9957261 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%