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Patent code US9957265

Compile Data Set for Download or QSAR

Found 226 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391489
PNG
((3S,4S)-3-{3-[(2-methyl-1,3-benzothiazol-6-yl)amin...)
Show SMILES Cc1nc2ccc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)cc2s1
Show InChI InChI=1/C20H18N6O2S/c1-11-23-14-3-2-13(8-17(14)29-11)24-19-18-15(4-6-22-20(18)27)26(25-19)16-10-28-7-5-12(16)9-21/h2-4,6,8,12,16H,5,7,10H2,1H3,(H,22,27)(H,24,25)/t12-,16?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391421
PNG
(US9957265, 1-34)
Show SMILES CC1N(C)S(=O)(=O)c2ccc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)cc12
Show InChI InChI=1/C21H22N6O4S/c1-12-15-9-14(3-4-18(15)32(29,30)26(12)2)24-20-19-16(5-7-23-21(19)28)27(25-20)17-11-31-8-6-13(17)10-22/h3-5,7,9,12-13,17H,6,8,11H2,1-2H3,(H,23,28)(H,24,25)/t12?,13-,17+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391466
PNG
(US9957265, 1-79)
Show SMILES CCN(C(C)(C)C)S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C24H30N6O4S/c1-5-29(24(2,3)4)35(32,33)18-8-6-17(7-9-18)27-22-21-19(10-12-26-23(21)31)30(28-22)20-15-34-13-11-16(20)14-25/h6-10,12,16,20H,5,11,13,15H2,1-4H3,(H,26,31)(H,27,28)/t16-,20+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391429
PNG
(US9957265, 1-42 | US9957265, 1-43)
Show SMILES FC(F)(F)C(N1CCCC1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C24H25F3N6O2/c25-24(26,27)21(32-10-1-2-11-32)15-3-5-17(6-4-15)30-22-20-18(7-9-29-23(20)34)33(31-22)19-14-35-12-8-16(19)13-28/h3-7,9,16,19,21H,1-2,8,10-12,14H2,(H,29,34)(H,30,31)/t16-,19+,21?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391451
PNG
(US9957265, 1-64)
Show SMILES CC(C)(C)OC(=O)CN1Cc2cc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
Show InChI InChI=1/C25H28N6O6S/c1-25(2,3)37-21(32)13-30-12-16-10-17(4-5-20(16)38(30,34)35)28-23-22-18(6-8-27-24(22)33)31(29-23)19-14-36-9-7-15(19)11-26/h4-6,8,10,15,19H,7,9,12-14H2,1-3H3,(H,27,33)(H,28,29)/t15-,19+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391391
PNG
(US9957265, 1-4)
Show SMILES CN1Cc2cc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
Show InChI InChI=1/C20H20N6O4S/c1-25-10-13-8-14(2-3-17(13)31(25,28)29)23-19-18-15(4-6-22-20(18)27)26(24-19)16-11-30-7-5-12(16)9-21/h2-4,6,8,12,16H,5,7,10-11H2,1H3,(H,22,27)(H,23,24)/t12-,16+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391420
PNG
(US9957265, 1-33)
Show SMILES COC(C)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C22H22F3N5O3/c1-21(32-2,22(23,24)25)14-3-5-15(6-4-14)28-19-18-16(7-9-27-20(18)31)30(29-19)17-12-33-10-8-13(17)11-26/h3-7,9,13,17H,8,10,12H2,1-2H3,(H,27,31)(H,28,29)/t13-,17+,21?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391464
PNG
(US9957265, 1-77 | US9957265, 1-78)
Show SMILES CC1CCN1S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C22H24N6O4S/c1-14-7-10-27(14)33(30,31)17-4-2-16(3-5-17)25-21-20-18(6-9-24-22(20)29)28(26-21)19-13-32-11-8-15(19)12-23/h2-6,9,14-15,19H,7-8,10-11,13H2,1H3,(H,24,29)(H,25,26)/t14?,15-,19+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391394
PNG
(US9957265, 1-62 | US9957265, 1-7)
Show SMILES FC(F)(F)CN1Cc2cc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
Show InChI InChI=1/C21H19F3N6O4S/c22-21(23,24)11-29-9-13-7-14(1-2-17(13)35(29,32)33)27-19-18-15(3-5-26-20(18)31)30(28-19)16-10-34-6-4-12(16)8-25/h1-3,5,7,12,16H,4,6,9-11H2,(H,26,31)(H,27,28)/t12-,16+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391405
PNG
(US9957265, 1-18 | US9957265, 1-19 | US9957265, 1-5...)
Show SMILES CN(C)C(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C22H23F3N6O2/c1-30(2)19(22(23,24)25)13-3-5-15(6-4-13)28-20-18-16(7-9-27-21(18)32)31(29-20)17-12-33-10-8-14(17)11-26/h3-7,9,14,17,19H,8,10,12H2,1-2H3,(H,27,32)(H,28,29)/t14-,17+,19?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391394
PNG
(US9957265, 1-62 | US9957265, 1-7)
Show SMILES FC(F)(F)CN1Cc2cc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
Show InChI InChI=1/C21H19F3N6O4S/c22-21(23,24)11-29-9-13-7-14(1-2-17(13)35(29,32)33)27-19-18-15(3-5-26-20(18)31)30(28-19)16-10-34-6-4-12(16)8-25/h1-3,5,7,12,16H,4,6,9-11H2,(H,26,31)(H,27,28)/t12-,16+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391487
PNG
(US9957265, 1-100 | US9957265, 1-101)
Show SMILES CC(C)NC1(C)C(=O)Nc2cc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12
Show InChI InChI=1/C24H27N7O3/c1-13(2)29-24(3)16-5-4-15(10-17(16)28-23(24)33)27-21-20-18(6-8-26-22(20)32)31(30-21)19-12-34-9-7-14(19)11-25/h4-6,8,10,13-14,19,29H,7,9,12H2,1-3H3,(H,26,32)(H,27,30)(H,28,33)/t14-,19?,24?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391491
PNG
(US9957265, 2-3 | US9957265, 2-4)
Show SMILES CC(O)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C21H20F3N5O3/c1-20(31,21(22,23)24)13-2-4-14(5-3-13)27-18-17-15(6-8-26-19(17)30)29(28-18)16-11-32-9-7-12(16)10-25/h2-6,8,12,16,31H,7,9,11H2,1H3,(H,26,30)(H,27,28)/t12-,16+,20?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391405
PNG
(US9957265, 1-18 | US9957265, 1-19 | US9957265, 1-5...)
Show SMILES CN(C)C(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C22H23F3N6O2/c1-30(2)19(22(23,24)25)13-3-5-15(6-4-13)28-20-18-16(7-9-27-21(18)32)31(29-20)17-12-33-10-8-14(17)11-26/h3-7,9,14,17,19H,8,10,12H2,1-2H3,(H,27,32)(H,28,29)/t14-,17+,19?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391429
PNG
(US9957265, 1-42 | US9957265, 1-43)
Show SMILES FC(F)(F)C(N1CCCC1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C24H25F3N6O2/c25-24(26,27)21(32-10-1-2-11-32)15-3-5-17(6-4-15)30-22-20-18(7-9-29-23(20)34)33(31-22)19-14-35-12-8-16(19)13-28/h3-7,9,16,19,21H,1-2,8,10-12,14H2,(H,29,34)(H,30,31)/t16-,19+,21?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391487
PNG
(US9957265, 1-100 | US9957265, 1-101)
Show SMILES CC(C)NC1(C)C(=O)Nc2cc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12
Show InChI InChI=1/C24H27N7O3/c1-13(2)29-24(3)16-5-4-15(10-17(16)28-23(24)33)27-21-20-18(6-8-26-22(20)32)31(30-21)19-12-34-9-7-14(19)11-25/h4-6,8,10,13-14,19,29H,7,9,12H2,1-3H3,(H,26,32)(H,27,30)(H,28,33)/t14-,19?,24?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391495
PNG
(US9957265, 2-7 | US9957265, 2-8)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C24H25F3N6O2/c25-24(26,27)23(9-1-2-10-30-23)16-3-5-17(6-4-16)31-21-20-18(7-11-29-22(20)34)33(32-21)19-14-35-12-8-15(19)13-28/h3-7,11,15,19,30H,1-2,8-10,12,14H2,(H,29,34)(H,31,32)/t15-,19+,23?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391495
PNG
(US9957265, 2-7 | US9957265, 2-8)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C24H25F3N6O2/c25-24(26,27)23(9-1-2-10-30-23)16-3-5-17(6-4-16)31-21-20-18(7-11-29-22(20)34)33(32-21)19-14-35-12-8-15(19)13-28/h3-7,11,15,19,30H,1-2,8-10,12,14H2,(H,29,34)(H,31,32)/t15-,19+,23?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391389
PNG
(US9957265, 1-2)
Show SMILES CS(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C19H19N5O4S/c1-29(26,27)14-4-2-13(3-5-14)22-18-17-15(6-8-21-19(17)25)24(23-18)16-11-28-9-7-12(16)10-20/h2-6,8,12,16H,7,9,11H2,1H3,(H,21,25)(H,22,23)/t12-,16+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391495
PNG
(US9957265, 2-7 | US9957265, 2-8)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C24H25F3N6O2/c25-24(26,27)23(9-1-2-10-30-23)16-3-5-17(6-4-16)31-21-20-18(7-11-29-22(20)34)33(32-21)19-14-35-12-8-15(19)13-28/h3-7,11,15,19,30H,1-2,8-10,12,14H2,(H,29,34)(H,31,32)/t15-,19+,23?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391490
PNG
(US9957265, 2-2)
Show SMILES CC1(C)C(=O)Nc2cc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12
Show InChI InChI=1/C22H22N6O3/c1-22(2)14-4-3-13(9-15(14)26-21(22)30)25-19-18-16(5-7-24-20(18)29)28(27-19)17-11-31-8-6-12(17)10-23/h3-5,7,9,12,17H,6,8,11H2,1-2H3,(H,24,29)(H,25,27)(H,26,30)/t12-,17?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391392
PNG
(US9957265, 1-5)
Show SMILES CC(C)(C)N1Cc2cc(Nc3nn([C@H]4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc2S1(=O)=O
Show InChI InChI=1/C23H26N6O4S/c1-23(2,3)28-12-15-10-16(4-5-19(15)34(28,31)32)26-21-20-17(6-8-25-22(20)30)29(27-21)18-13-33-9-7-14(18)11-24/h4-6,8,10,14,18H,7,9,12-13H2,1-3H3,(H,25,30)(H,26,27)/t14-,18+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391485
PNG
(US9957265, 1-98 | US9957265, 1-99)
Show SMILES FC(F)(F)C1(CCNC1)c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C23H23F3N6O2/c24-23(25,26)22(7-9-28-13-22)15-1-3-16(4-2-15)30-20-19-17(5-8-29-21(19)33)32(31-20)18-12-34-10-6-14(18)11-27/h1-5,8,14,18,28H,6-7,9-10,12-13H2,(H,29,33)(H,30,31)/t14-,18?,22?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391495
PNG
(US9957265, 2-7 | US9957265, 2-8)
Show SMILES FC(F)(F)C1(CCCCN1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C24H25F3N6O2/c25-24(26,27)23(9-1-2-10-30-23)16-3-5-17(6-4-16)31-21-20-18(7-11-29-22(20)34)33(32-21)19-14-35-12-8-15(19)13-28/h3-7,11,15,19,30H,1-2,8-10,12,14H2,(H,29,34)(H,31,32)/t15-,19+,23?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391491
PNG
(US9957265, 2-3 | US9957265, 2-4)
Show SMILES CC(O)(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C21H20F3N5O3/c1-20(31,21(22,23)24)13-2-4-14(5-3-13)27-18-17-15(6-8-26-19(17)30)29(28-18)16-11-32-9-7-12(16)10-25/h2-6,8,12,16,31H,7,9,11H2,1H3,(H,26,30)(H,27,28)/t12-,16+,20?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391443
PNG
(US9957265, 1-56 | US9957265, 1-57)
Show SMILES FC(F)(F)C(N1CCC1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C23H23F3N6O2/c24-23(25,26)20(31-9-1-10-31)14-2-4-16(5-3-14)29-21-19-17(6-8-28-22(19)33)32(30-21)18-13-34-11-7-15(18)12-27/h2-6,8,15,18,20H,1,7,9-11,13H2,(H,28,33)(H,29,30)/t15-,18+,20?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391395
PNG
(US9957265, 1-8 | US9957265, 1-9)
Show SMILES NC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C20H19F3N6O2/c21-20(22,23)17(25)11-1-3-13(4-2-11)27-18-16-14(5-7-26-19(16)30)29(28-18)15-10-31-8-6-12(15)9-24/h1-5,7,12,15,17H,6,8,10,25H2,(H,26,30)(H,27,28)/t12-,15+,17?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391481
PNG
(US9957265, 1-94 | US9957265, 1-95)
Show SMILES OC(c1ccncc1)(c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C25H21F3N6O3/c26-25(27,28)24(36,17-5-9-30-10-6-17)16-1-3-18(4-2-16)32-22-21-19(7-11-31-23(21)35)34(33-22)20-14-37-12-8-15(20)13-29/h1-7,9-11,15,20,36H,8,12,14H2,(H,31,35)(H,32,33)/t15-,20?,24?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391487
PNG
(US9957265, 1-100 | US9957265, 1-101)
Show SMILES CC(C)NC1(C)C(=O)Nc2cc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12
Show InChI InChI=1/C24H27N7O3/c1-13(2)29-24(3)16-5-4-15(10-17(16)28-23(24)33)27-21-20-18(6-8-26-22(20)32)31(30-21)19-12-34-9-7-14(19)11-25/h4-6,8,10,13-14,19,29H,7,9,12H2,1-3H3,(H,26,32)(H,27,30)(H,28,33)/t14-,19?,24?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391441
PNG
(US9957265, 1-54 | US9957265, 1-55)
Show SMILES CCNC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C22H23F3N6O2/c1-2-27-19(22(23,24)25)13-3-5-15(6-4-13)29-20-18-16(7-9-28-21(18)32)31(30-20)17-12-33-10-8-14(17)11-26/h3-7,9,14,17,19,27H,2,8,10,12H2,1H3,(H,28,32)(H,29,30)/t14-,17+,19?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391485
PNG
(US9957265, 1-98 | US9957265, 1-99)
Show SMILES FC(F)(F)C1(CCNC1)c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C23H23F3N6O2/c24-23(25,26)22(7-9-28-13-22)15-1-3-16(4-2-15)30-20-19-17(5-8-29-21(19)33)32(31-20)18-12-34-10-6-14(18)11-27/h1-5,8,14,18,28H,6-7,9-10,12-13H2,(H,29,33)(H,30,31)/t14-,18?,22?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391405
PNG
(US9957265, 1-18 | US9957265, 1-19 | US9957265, 1-5...)
Show SMILES CN(C)C(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C22H23F3N6O2/c1-30(2)19(22(23,24)25)13-3-5-15(6-4-13)28-20-18-16(7-9-27-21(18)32)31(29-20)17-12-33-10-8-14(17)11-26/h3-7,9,14,17,19H,8,10,12H2,1-2H3,(H,27,32)(H,28,29)/t14-,17+,19?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391483
PNG
(US9957265, 1-96 | US9957265, 1-97)
Show SMILES OC(c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)(c1ccccn1)C(F)(F)F
Show InChI InChI=1/C25H21F3N6O3/c26-25(27,28)24(36,20-3-1-2-10-30-20)16-4-6-17(7-5-16)32-22-21-18(8-11-31-23(21)35)34(33-22)19-14-37-12-9-15(19)13-29/h1-8,10-11,15,19,36H,9,12,14H2,(H,31,35)(H,32,33)/t15-,19?,24?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391407
PNG
(US9957265, 1-20 | US9957265, 1-21)
Show SMILES CC1(C)CCCC(O)(C1)c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C26H31N5O3/c1-25(2)10-3-11-26(33,16-25)18-4-6-19(7-5-18)29-23-22-20(8-12-28-24(22)32)31(30-23)21-15-34-13-9-17(21)14-27/h4-8,12,17,21,33H,3,9-11,13,15-16H2,1-2H3,(H,28,32)(H,29,30)/t17-,21?,26?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391405
PNG
(US9957265, 1-18 | US9957265, 1-19 | US9957265, 1-5...)
Show SMILES CN(C)C(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C22H23F3N6O2/c1-30(2)19(22(23,24)25)13-3-5-15(6-4-13)28-20-18-16(7-9-27-21(18)32)31(29-20)17-12-33-10-8-14(17)11-26/h3-7,9,14,17,19H,8,10,12H2,1-2H3,(H,27,32)(H,28,29)/t14-,17+,19?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391487
PNG
(US9957265, 1-100 | US9957265, 1-101)
Show SMILES CC(C)NC1(C)C(=O)Nc2cc(Nc3nn(C4COCC[C@@H]4C#N)c4cc[nH]c(=O)c34)ccc12
Show InChI InChI=1/C24H27N7O3/c1-13(2)29-24(3)16-5-4-15(10-17(16)28-23(24)33)27-21-20-18(6-8-26-22(20)32)31(30-21)19-12-34-9-7-14(19)11-25/h4-6,8,10,13-14,19,29H,7,9,12H2,1-3H3,(H,26,32)(H,27,30)(H,28,33)/t14-,19?,24?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391467
PNG
(US9957265, 1-80 | US9957265, 1-81)
Show SMILES FC(F)(F)C(NC1CC1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C23H23F3N6O2/c24-23(25,26)20(29-15-5-6-15)13-1-3-16(4-2-13)30-21-19-17(7-9-28-22(19)33)32(31-21)18-12-34-10-8-14(18)11-27/h1-4,7,9,14-15,18,20,29H,5-6,8,10,12H2,(H,28,33)(H,30,31)/t14-,18+,20?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391393
PNG
(US9957265, 1-6)
Show SMILES CN(C)S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C20H22N6O4S/c1-25(2)31(28,29)15-5-3-14(4-6-15)23-19-18-16(7-9-22-20(18)27)26(24-19)17-12-30-10-8-13(17)11-21/h3-7,9,13,17H,8,10,12H2,1-2H3,(H,22,27)(H,23,24)/t13-,17+/s2
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n/an/a 70n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391453
PNG
(US9957265, 1-66)
Show SMILES CC(C)C(C)(C)S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C24H29N5O4S/c1-15(2)24(3,4)34(31,32)18-7-5-17(6-8-18)27-22-21-19(9-11-26-23(21)30)29(28-22)20-14-33-12-10-16(20)13-25/h5-9,11,15-16,20H,10,12,14H2,1-4H3,(H,26,30)(H,27,28)/t16-,20+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391456
PNG
(US9957265, 1-69)
Show SMILES O=c1[nH]ccc2n(nc(Nc3ccc(cc3)S(=O)(=O)N3CCC3)c12)[C@H]1COCC[C@@H]1C#N
Show InChI InChI=1/C21H22N6O4S/c22-12-14-7-11-31-13-18(14)27-17-6-8-23-21(28)19(17)20(25-27)24-15-2-4-16(5-3-15)32(29,30)26-9-1-10-26/h2-6,8,14,18H,1,7,9-11,13H2,(H,23,28)(H,24,25)/t14-,18+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391466
PNG
(US9957265, 1-79)
Show SMILES CCN(C(C)(C)C)S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C24H30N6O4S/c1-5-29(24(2,3)4)35(32,33)18-8-6-17(7-9-18)27-22-21-19(10-12-26-23(21)31)30(28-22)20-15-34-13-11-16(20)14-25/h6-10,12,16,20H,5,11,13,15H2,1-4H3,(H,26,31)(H,27,28)/t16-,20+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391481
PNG
(US9957265, 1-94 | US9957265, 1-95)
Show SMILES OC(c1ccncc1)(c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C25H21F3N6O3/c26-25(27,28)24(36,17-5-9-30-10-6-17)16-1-3-18(4-2-16)32-22-21-19(7-11-31-23(21)35)34(33-22)20-14-37-12-8-15(20)13-29/h1-7,9-11,15,20,36H,8,12,14H2,(H,31,35)(H,32,33)/t15-,20?,24?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391407
PNG
(US9957265, 1-20 | US9957265, 1-21)
Show SMILES CC1(C)CCCC(O)(C1)c1ccc(Nc2nn(C3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C26H31N5O3/c1-25(2)10-3-11-26(33,16-25)18-4-6-19(7-5-18)29-23-22-20(8-12-28-24(22)32)31(30-23)21-15-34-13-9-17(21)14-27/h4-8,12,17,21,33H,3,9-11,13,15-16H2,1-2H3,(H,28,32)(H,29,30)/t17-,21?,26?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391439
PNG
(US9957265, 1-52 | US9957265, 1-53)
Show SMILES CC(C)NC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C23H25F3N6O2/c1-13(2)29-20(23(24,25)26)14-3-5-16(6-4-14)30-21-19-17(7-9-28-22(19)33)32(31-21)18-12-34-10-8-15(18)11-27/h3-7,9,13,15,18,20,29H,8,10,12H2,1-2H3,(H,28,33)(H,30,31)/t15-,18+,20?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391400
PNG
(US9957265, 1-13)
Show SMILES CC(C)(C)S(=O)(=O)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C22H25N5O4S/c1-22(2,3)32(29,30)16-6-4-15(5-7-16)25-20-19-17(8-10-24-21(19)28)27(26-20)18-13-31-11-9-14(18)12-23/h4-8,10,14,18H,9,11,13H2,1-3H3,(H,24,28)(H,25,26)/t14-,18+/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391439
PNG
(US9957265, 1-52 | US9957265, 1-53)
Show SMILES CC(C)NC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C23H25F3N6O2/c1-13(2)29-20(23(24,25)26)14-3-5-16(6-4-14)30-21-19-17(7-9-28-22(19)33)32(31-21)18-12-34-10-8-15(18)11-27/h3-7,9,13,15,18,20,29H,8,10,12H2,1-2H3,(H,28,33)(H,30,31)/t15-,18+,20?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391405
PNG
(US9957265, 1-18 | US9957265, 1-19 | US9957265, 1-5...)
Show SMILES CN(C)C(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C22H23F3N6O2/c1-30(2)19(22(23,24)25)13-3-5-15(6-4-13)28-20-18-16(7-9-27-21(18)32)31(29-20)17-12-33-10-8-14(17)11-26/h3-7,9,14,17,19H,8,10,12H2,1-2H3,(H,27,32)(H,28,29)/t14-,17+,19?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))
BDBM391429
PNG
(US9957265, 1-42 | US9957265, 1-43)
Show SMILES FC(F)(F)C(N1CCCC1)c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1
Show InChI InChI=1/C24H25F3N6O2/c25-24(26,27)21(32-10-1-2-11-32)15-3-5-17(6-4-15)30-22-20-18(7-9-29-23(20)34)33(31-22)19-14-35-12-8-16(19)13-28/h3-7,9,16,19,21H,1-2,8,10-12,14H2,(H,29,34)(H,30,31)/t16-,19+,21?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391437
PNG
(US9957265, 1-50 | US9957265, 1-51)
Show SMILES CC(C)(C)NC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C24H27F3N6O2/c1-23(2,3)31-20(24(25,26)27)14-4-6-16(7-5-14)30-21-19-17(8-10-29-22(19)34)33(32-21)18-13-35-11-9-15(18)12-28/h4-8,10,15,18,20,31H,9,11,13H2,1-3H3,(H,29,34)(H,30,32)/t15-,18+,20?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase JAK1


(Homo sapiens (Human))
BDBM391441
PNG
(US9957265, 1-54 | US9957265, 1-55)
Show SMILES CCNC(c1ccc(Nc2nn([C@H]3COCC[C@@H]3C#N)c3cc[nH]c(=O)c23)cc1)C(F)(F)F
Show InChI InChI=1/C22H23F3N6O2/c1-2-27-19(22(23,24)25)13-3-5-15(6-4-13)29-20-18-16(7-9-28-21(18)32)31(30-20)17-12-33-10-8-14(17)11-26/h3-7,9,14,17,19,27H,2,8,10,12H2,1H3,(H,28,32)(H,29,30)/t14-,17+,19?/s2
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The ability of compounds to inhibit the activity of JAK1, JAK2, JAK3, and TYK2 was measured using a recombinant purified GST-tagged catalytic domain ...


US Patent US9957265 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%