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Patent code US9962388

Compile Data Set for Download or QSAR
Found 45 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393000
PNG
(2-butoxy-7-(4-((dipropylamino)methyl)benzyl)-5H-py...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN(CCC)CCC)cc3)c2n1
Show InChI InChI=1S/C24H35N5O/c1-4-7-14-30-24-27-21-20(16-26-22(21)23(25)28-24)15-18-8-10-19(11-9-18)17-29(12-5-2)13-6-3/h8-11,16,26H,4-7,12-15,17H2,1-3H3,(H2,25,27,28)
PDB

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PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393039
PNG
(4-amino-2-butoxy-7-(4-(pyrrolidine-1-ylmethyl)benz...)
Show SMILES CCCCOc1nc(N)c2[nH]c(C(N)=O)c(Cc3ccc(CN4CCCC4)cc3)c2n1
Show InChI InChI=1S/C23H30N6O2/c1-2-3-12-31-23-27-18-17(19(22(25)30)26-20(18)21(24)28-23)13-15-6-8-16(9-7-15)14-29-10-4-5-11-29/h6-9,26H,2-5,10-14H2,1H3,(H2,25,30)(H2,24,27,28)
PDB

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PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393038
PNG
(4-amino-2-butoxy-7-(4-((4-methylpiperazine-1-yl)me...)
Show SMILES CCCCOc1nc(N)c2[nH]c(C#N)c(Cc3ccc(CN4CCN(C)CC4)cc3)c2n1
Show InChI InChI=1S/C24H31N7O/c1-3-4-13-32-24-28-21-19(20(15-25)27-22(21)23(26)29-24)14-17-5-7-18(8-6-17)16-31-11-9-30(2)10-12-31/h5-8,27H,3-4,9-14,16H2,1-2H3,(H2,26,28,29)
PDB

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PC sid
UniChem
US Patent
n/an/an/an/a 0.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393027
PNG
(2-butoxy-7-((2-methyl-1,2,3,4-tetrahydroisoquinoli...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc4CN(C)CCc4c3)c2n1
Show InChI InChI=1S/C21H27N5O/c1-3-4-9-27-21-24-18-17(12-23-19(18)20(22)25-21)11-14-5-6-16-13-26(2)8-7-15(16)10-14/h5-6,10,12,23H,3-4,7-9,11,13H2,1-2H3,(H2,22,24,25)
PDB

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UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392988
PNG
(2-butoxy-7-(3-((4-methylpiperazine-1-yl)methyl)ben...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3cccc(CN4CCN(C)CC4)c3)c2n1
Show InChI InChI=1S/C23H32N6O/c1-3-4-12-30-23-26-20-19(15-25-21(20)22(24)27-23)14-17-6-5-7-18(13-17)16-29-10-8-28(2)9-11-29/h5-7,13,15,25H,3-4,8-12,14,16H2,1-2H3,(H2,24,26,27)
PDB

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PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393034
PNG
(2-butoxy-7-((5-(pyrrolidine-1-ylmethyl)pyridine-2-...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCCC4)cn3)c2n1
Show InChI InChI=1S/C21H28N6O/c1-2-3-10-28-21-25-18-16(13-24-19(18)20(22)26-21)11-17-7-6-15(12-23-17)14-27-8-4-5-9-27/h6-7,12-13,24H,2-5,8-11,14H2,1H3,(H2,22,25,26)
PDB

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PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393022
PNG
(2-butoxy-7-((1,2,3,4-tetrahydroisoquinoline-7-yl)m...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc4CCNCc4c3)c2n1
Show InChI InChI=1S/C20H25N5O/c1-2-3-8-26-20-24-17-16(12-23-18(17)19(21)25-20)10-13-4-5-14-6-7-22-11-15(14)9-13/h4-5,9,12,22-23H,2-3,6-8,10-11H2,1H3,(H2,21,24,25)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393028
PNG
(2-butoxy-7-((2-ethyl-1,2,3,4-tetrahydroisoquinolin...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc4CN(CC)CCc4c3)c2n1
Show InChI InChI=1S/C22H29N5O/c1-3-5-10-28-22-25-19-18(13-24-20(19)21(23)26-22)12-15-6-7-17-14-27(4-2)9-8-16(17)11-15/h6-7,11,13,24H,3-5,8-10,12,14H2,1-2H3,(H2,23,25,26)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392995
PNG
(2-butoxy-7-(4-(piperidine-1-ylmethyl)benzyl)-5H-py...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCCCC4)cc3)c2n1
Show InChI InChI=1S/C23H31N5O/c1-2-3-13-29-23-26-20-19(15-25-21(20)22(24)27-23)14-17-7-9-18(10-8-17)16-28-11-5-4-6-12-28/h7-10,15,25H,2-6,11-14,16H2,1H3,(H2,24,26,27)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392999
PNG
(2-butoxy-7-(4-((diethylamino)methyl)benzyl)-5H-pyr...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN(CC)CC)cc3)c2n1
Show InChI InChI=1S/C22H31N5O/c1-4-7-12-28-22-25-19-18(14-24-20(19)21(23)26-22)13-16-8-10-17(11-9-16)15-27(5-2)6-3/h8-11,14,24H,4-7,12-13,15H2,1-3H3,(H2,23,25,26)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393002
PNG
(2-butoxy-7-(4-((3-methoxylazetidin-1-yl)methyl)ben...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CC(C4)OC)cc3)c2n1
Show InChI InChI=1S/C22H29N5O2/c1-3-4-9-29-22-25-19-17(11-24-20(19)21(23)26-22)10-15-5-7-16(8-6-15)12-27-13-18(14-27)28-2/h5-8,11,18,24H,3-4,9-10,12-14H2,1-2H3,(H2,23,25,26)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393005
PNG
(2-butoxy-7-(4-((2,6-dimethylmorpholinyl)methyl)ben...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CC(C)OC(C)C4)cc3)c2n1
Show InChI InChI=1/C24H33N5O2/c1-4-5-10-30-24-27-21-20(12-26-22(21)23(25)28-24)11-18-6-8-19(9-7-18)15-29-13-16(2)31-17(3)14-29/h6-9,12,16-17,26H,4-5,10-11,13-15H2,1-3H3,(H2,25,27,28)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393016
PNG
(2-butoxy-7-((6-(pyrrolidine-1-ylmethyl)pyridine-3-...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCCC4)nc3)c2n1
Show InChI InChI=1S/C21H28N6O/c1-2-3-10-28-21-25-18-16(13-24-19(18)20(22)26-21)11-15-6-7-17(23-12-15)14-27-8-4-5-9-27/h6-7,12-13,24H,2-5,8-11,14H2,1H3,(H2,22,25,26)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393031
PNG
(7-((5-chloropyridine-2-yl)methyl)-2-(2-methoxyleth...)
Show SMILES COCCOc1nc(N)c2[nH]cc(Cc3ccc(Cl)cn3)c2n1
Show InChI InChI=1S/C15H16ClN5O2/c1-22-4-5-23-15-20-12-9(7-19-13(12)14(17)21-15)6-11-3-2-10(16)8-18-11/h2-3,7-8,19H,4-6H2,1H3,(H2,17,20,21)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392998
PNG
(2-butoxy-7-(4-((dimethylamino)methyl)benzyl)-5H-py...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN(C)C)cc3)c2n1
Show InChI InChI=1S/C20H27N5O/c1-4-5-10-26-20-23-17-16(12-22-18(17)19(21)24-20)11-14-6-8-15(9-7-14)13-25(2)3/h6-9,12,22H,4-5,10-11,13H2,1-3H3,(H2,21,23,24)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393001
PNG
(7-(4-(azetidin-1-ylmethyl)benzyl)-2-butoxy-5H-pyrr...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCC4)cc3)c2n1
Show InChI InChI=1S/C21H27N5O/c1-2-3-11-27-21-24-18-17(13-23-19(18)20(22)25-21)12-15-5-7-16(8-6-15)14-26-9-4-10-26/h5-8,13,23H,2-4,9-12,14H2,1H3,(H2,22,24,25)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393017
PNG
(2-butoxy-7-(3-(2-(pyrrolidine-1-yl)ethyl)benzyl)-5...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3cccc(CCN4CCCC4)c3)c2n1
Show InChI InChI=1S/C23H31N5O/c1-2-3-13-29-23-26-20-19(16-25-21(20)22(24)27-23)15-18-8-6-7-17(14-18)9-12-28-10-4-5-11-28/h6-8,14,16,25H,2-5,9-13,15H2,1H3,(H2,24,26,27)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 55n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393037
PNG
(4-amino-2-butoxy-7-(4-(morpholinomethyl)benzyl)-5H...)
Show SMILES CCCCOc1nc(N)c2[nH]c(C#N)c(Cc3ccc(CN4CCOCC4)cc3)c2n1
Show InChI InChI=1S/C23H28N6O2/c1-2-3-10-31-23-27-20-18(19(14-24)26-21(20)22(25)28-23)13-16-4-6-17(7-5-16)15-29-8-11-30-12-9-29/h4-7,26H,2-3,8-13,15H2,1H3,(H2,25,27,28)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393018
PNG
(2-butoxy-7-(4-(1-(pyrrolidine-1-yl)ethyl)benzyl)-5...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(cc3)C(C)N3CCCC3)c2n1
Show InChI InChI=1/C23H31N5O/c1-3-4-13-29-23-26-20-19(15-25-21(20)22(24)27-23)14-17-7-9-18(10-8-17)16(2)28-11-5-6-12-28/h7-10,15-16,25H,3-6,11-14H2,1-2H3,(H2,24,26,27)
PDB

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393019
PNG
(2-butoxy-7-(4-(1-methylpiperidine-4-yl)benzyl)-5H-...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(cc3)C3CCN(C)CC3)c2n1
Show InChI InChI=1S/C23H31N5O/c1-3-4-13-29-23-26-20-19(15-25-21(20)22(24)27-23)14-16-5-7-17(8-6-16)18-9-11-28(2)12-10-18/h5-8,15,18,25H,3-4,9-14H2,1-2H3,(H2,24,26,27)
PDB

UniProtKB/SwissProt

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PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 0.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392994
PNG
(1-(4-((4-amino-2-butoxy-5H-pyrrolo[3,2-d]pyrimidin...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCC(O)C4)cc3)c2n1
Show InChI InChI=1/C22H29N5O2/c1-2-3-10-29-22-25-19-17(12-24-20(19)21(23)26-22)11-15-4-6-16(7-5-15)13-27-9-8-18(28)14-27/h4-7,12,18,24,28H,2-3,8-11,13-14H2,1H3,(H2,23,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393013
PNG
(2-butoxy-7-(4-((4-methoxylpiperidine-1-yl)methyl)b...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCC(CC4)OC)cc3)c2n1
Show InChI InChI=1S/C24H33N5O2/c1-3-4-13-31-24-27-21-19(15-26-22(21)23(25)28-24)14-17-5-7-18(8-6-17)16-29-11-9-20(30-2)10-12-29/h5-8,15,20,26H,3-4,9-14,16H2,1-2H3,(H2,25,27,28)
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n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393035
PNG
(4-amino-2-butoxy-7-((6-(pyrrolidine-1-ylmethyl)pyr...)
Show SMILES CCCCOc1nc(N)c2[nH]c(C#N)c(Cc3ccc(CN4CCCC4)nc3)c2n1
Show InChI InChI=1S/C22H27N7O/c1-2-3-10-30-22-27-19-17(18(12-23)26-20(19)21(24)28-22)11-15-6-7-16(25-13-15)14-29-8-4-5-9-29/h6-7,13,26H,2-5,8-11,14H2,1H3,(H2,24,27,28)
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n/an/an/an/a 0.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393021
PNG
(1-(4-((4-amino-2-butoxy-5H-pyrrolo[3,2-d]pyrimidin...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(cc3)N3CCN(C)CC3=O)c2n1
Show InChI InChI=1S/C22H28N6O2/c1-3-4-11-30-22-25-19-16(13-24-20(19)21(23)26-22)12-15-5-7-17(8-6-15)28-10-9-27(2)14-18(28)29/h5-8,13,24H,3-4,9-12,14H2,1-2H3,(H2,23,25,26)
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n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393023
PNG
(2-butoxy-7-((2-methyl-1,2,3,4-tetrahydroisoquinoli...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc4CCN(C)Cc4c3)c2n1
Show InChI InChI=1S/C21H27N5O/c1-3-4-9-27-21-24-18-16(12-23-19(18)20(22)25-21)10-14-5-6-15-7-8-26(2)13-17(15)11-14/h5-6,11-12,23H,3-4,7-10,13H2,1-2H3,(H2,22,24,25)
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n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393029
PNG
(7-benzyl-2-(2-methoxylethoxyl)-5H-pyrrolo[3,2-d]py...)
Show SMILES COCCOc1nc(N)c2[nH]cc(Cc3ccccc3)c2n1
Show InChI InChI=1S/C16H18N4O2/c1-21-7-8-22-16-19-13-12(9-11-5-3-2-4-6-11)10-18-14(13)15(17)20-16/h2-6,10,18H,7-9H2,1H3,(H2,17,19,20)
PDB

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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393032
PNG
(2-(2-methoxylethoxyl-)-7-((6-(pyrrolidine-1-ylmeth...)
Show SMILES COCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCCC4)nc3)c2n1
Show InChI InChI=1S/C20H26N6O2/c1-27-8-9-28-20-24-17-15(12-23-18(17)19(21)25-20)10-14-4-5-16(22-11-14)13-26-6-2-3-7-26/h4-5,11-12,23H,2-3,6-10,13H2,1H3,(H2,21,24,25)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392993
PNG
(2-butoxy-7-(4-((3-fluoropyrrolidine-1-yl)methyl)be...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCC(F)C4)cc3)c2n1
Show InChI InChI=1/C22H28FN5O/c1-2-3-10-29-22-26-19-17(12-25-20(19)21(24)27-22)11-15-4-6-16(7-5-15)13-28-9-8-18(23)14-28/h4-7,12,18,25H,2-3,8-11,13-14H2,1H3,(H2,24,26,27)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392997
PNG
(2-butoxy-7-(4-((4-methylpiperazine-1-yl)methyl)ben...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCN(C)CC4)cc3)c2n1
Show InChI InChI=1S/C23H32N6O/c1-3-4-13-30-23-26-20-19(15-25-21(20)22(24)27-23)14-17-5-7-18(8-6-17)16-29-11-9-28(2)10-12-29/h5-8,15,25H,3-4,9-14,16H2,1-2H3,(H2,24,26,27)
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n/an/an/an/a 55n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393036
PNG
(4-amino-2-butoxy-7-(4-(pyrrolidine-1-ylmethyl)benz...)
Show SMILES CCCCOc1nc(N)c2[nH]c(C#N)c(Cc3ccc(CN4CCCC4)cc3)c2n1
Show InChI InChI=1S/C23H28N6O/c1-2-3-12-30-23-27-20-18(19(14-24)26-21(20)22(25)28-23)13-16-6-8-17(9-7-16)15-29-10-4-5-11-29/h6-9,26H,2-5,10-13,15H2,1H3,(H2,25,27,28)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393025
PNG
(2-butoxy-7-((2-isopropyl-1,2,3,4-tetrahydroisoquin...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc4CCN(Cc4c3)C(C)C)c2n1
Show InChI InChI=1S/C23H31N5O/c1-4-5-10-29-23-26-20-18(13-25-21(20)22(24)27-23)11-16-6-7-17-8-9-28(15(2)3)14-19(17)12-16/h6-7,12-13,15,25H,4-5,8-11,14H2,1-3H3,(H2,24,26,27)
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n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393030
PNG
(2-(2-methoxylethoxyl)-7-((6-methylpyridine-3-yl)me...)
Show SMILES COCCOc1nc(N)c2[nH]cc(Cc3ccc(C)nc3)c2n1
Show InChI InChI=1S/C16H19N5O2/c1-10-3-4-11(8-18-10)7-12-9-19-14-13(12)20-16(21-15(14)17)23-6-5-22-2/h3-4,8-9,19H,5-7H2,1-2H3,(H2,17,20,21)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392990
PNG
(7-(3-(aminomethyl)benzyl)-2-butoxy-5H-pyrrolo[3,2-...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3cccc(CN)c3)c2n1
Show InChI InChI=1S/C18H23N5O/c1-2-3-7-24-18-22-15-14(11-21-16(15)17(20)23-18)9-12-5-4-6-13(8-12)10-19/h4-6,8,11,21H,2-3,7,9-10,19H2,1H3,(H2,20,22,23)
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n/an/an/an/a 55n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392992
PNG
(2-butoxy-7-(4-((3,3-difluoropyrrolidine-1-yl)methy...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCC(F)(F)C4)cc3)c2n1
Show InChI InChI=1S/C22H27F2N5O/c1-2-3-10-30-21-27-18-17(12-26-19(18)20(25)28-21)11-15-4-6-16(7-5-15)13-29-9-8-22(23,24)14-29/h4-7,12,26H,2-3,8-11,13-14H2,1H3,(H2,25,27,28)
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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392996
PNG
(2-butoxy-7-(4-(morpholinomethyl)benzyl)-5H-pyrrolo...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCOCC4)cc3)c2n1
Show InChI InChI=1S/C22H29N5O2/c1-2-3-10-29-22-25-19-18(14-24-20(19)21(23)26-22)13-16-4-6-17(7-5-16)15-27-8-11-28-12-9-27/h4-7,14,24H,2-3,8-13,15H2,1H3,(H2,23,25,26)
PDB

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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393004
PNG
(2-butoxy-7-(4-((4-methyl-1,4-diazepan-1-yl)methyl)...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCCN(C)CC4)cc3)c2n1
Show InChI InChI=1S/C24H34N6O/c1-3-4-14-31-24-27-21-20(16-26-22(21)23(25)28-24)15-18-6-8-19(9-7-18)17-30-11-5-10-29(2)12-13-30/h6-9,16,26H,3-5,10-15,17H2,1-2H3,(H2,25,27,28)
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n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393006
PNG
(7-(4-((1 S,4S)-2-oxa-5-azabicyclo[2.2.1]heptane-5-...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4C[C@@H]5C[C@H]4CO5)cc3)c2n1
Show InChI InChI=1/C23H29N5O2/c1-2-3-8-29-23-26-20-17(11-25-21(20)22(24)27-23)9-15-4-6-16(7-5-15)12-28-13-19-10-18(28)14-30-19/h4-7,11,18-19,25H,2-3,8-10,12-14H2,1H3,(H2,24,26,27)/t18-,19-/s2
PDB

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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393015
PNG
(2-butoxy-7-(4-(pyrrolidine-1-ylmethyl)benzyl)-5H-p...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCCC4)cc3)c2n1
Show InChI InChI=1S/C22H29N5O/c1-2-3-12-28-22-25-19-18(14-24-20(19)21(23)26-22)13-16-6-8-17(9-7-16)15-27-10-4-5-11-27/h6-9,14,24H,2-5,10-13,15H2,1H3,(H2,23,25,26)
PDB

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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393020
PNG
(2-butoxy-7-(4-(1-methylpyrrolidine-2-yl)benzyl)-5H...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(cc3)C3CCCN3C)c2n1
Show InChI InChI=1/C22H29N5O/c1-3-4-12-28-22-25-19-17(14-24-20(19)21(23)26-22)13-15-7-9-16(10-8-15)18-6-5-11-27(18)2/h7-10,14,18,24H,3-6,11-13H2,1-2H3,(H2,23,25,26)
PDB

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n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393024
PNG
(2-butoxy-7-((2-ethyl-1,2,3,4-tetrahydroisoquinolin...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc4CCN(CC)Cc4c3)c2n1
Show InChI InChI=1S/C22H29N5O/c1-3-5-10-28-22-25-19-17(13-24-20(19)21(23)26-22)11-15-6-7-16-8-9-27(4-2)14-18(16)12-15/h6-7,12-13,24H,3-5,8-11,14H2,1-2H3,(H2,23,25,26)
PDB

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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393026
PNG
(2-butoxy-7-((1,2,3,4-tetrahydroisoquinoline-6-yl)m...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc4CNCCc4c3)c2n1
Show InChI InChI=1S/C20H25N5O/c1-2-3-8-26-20-24-17-16(12-23-18(17)19(21)25-20)10-13-4-5-15-11-22-7-6-14(15)9-13/h4-5,9,12,22-23H,2-3,6-8,10-11H2,1H3,(H2,21,24,25)
PDB

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n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392989
PNG
(2-butoxy-7-(3-(morpholinomethyl)benzyl)-5H-pyrrolo...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3cccc(CN4CCOCC4)c3)c2n1
Show InChI InChI=1S/C22H29N5O2/c1-2-3-9-29-22-25-19-18(14-24-20(19)21(23)26-22)13-16-5-4-6-17(12-16)15-27-7-10-28-11-8-27/h4-6,12,14,24H,2-3,7-11,13,15H2,1H3,(H2,23,25,26)
PDB

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CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM392991
PNG
(2-butoxy-7-(3-(pyrrolidine-1-ylmethyl)benzyl)-5H-p...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3cccc(CN4CCCC4)c3)c2n1
Show InChI InChI=1S/C22H29N5O/c1-2-3-11-28-22-25-19-18(14-24-20(19)21(23)26-22)13-16-7-6-8-17(12-16)15-27-9-4-5-10-27/h6-8,12,14,24H,2-5,9-11,13,15H2,1H3,(H2,23,25,26)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393033
PNG
(1-(4-((4-amino-2-(2-methoxylethoxyl)-5H-pyrrolo[3,...)
Show SMILES COCCOc1nc(N)c2[nH]cc(Cc3ccc(cc3)N3CCN(C)CC3=O)c2n1
Show InChI InChI=1S/C21H26N6O3/c1-26-7-8-27(17(28)13-26)16-5-3-14(4-6-16)11-15-12-23-19-18(15)24-21(25-20(19)22)30-10-9-29-2/h3-6,12,23H,7-11,13H2,1-2H3,(H2,22,24,25)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
Toll-like receptor 7


(Homo sapiens (Human))
BDBM393014
PNG
(2-butoxy-7-(4-((4-isopropylpiperazine-1-yl)methyl)...)
Show SMILES CCCCOc1nc(N)c2[nH]cc(Cc3ccc(CN4CCN(CC4)C(C)C)cc3)c2n1
Show InChI InChI=1S/C25H36N6O/c1-4-5-14-32-25-28-22-21(16-27-23(22)24(26)29-25)15-19-6-8-20(9-7-19)17-30-10-12-31(13-11-30)18(2)3/h6-9,16,18,27H,4-5,10-15,17H2,1-3H3,(H2,26,28,29)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 5.5n/an/an/an/a



CHIA TAI TIANQING PHARMACEUTICAL GROUP CO., LTD.

US Patent


Assay Description
Reagents:HEK-blue hTLR7 cell and HEK-blue hTLR8 cell (available from InvivoGen)DMEM mediumheat inactivated fetal bovine serumAnti Mycoplasma reagent ...


US Patent US9962388 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%