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Patent code US9963446

Compile Data Set for Download or QSAR
Found 26 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393298
PNG
(N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...)
Show SMILES C[C@H](F)c1cc(F)c(-c2nc(cs2)C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(F)c1
Show InChI InChI=1S/C22H23F4N5O2S/c1-10(23)11-5-12(24)19(13(25)6-11)22-30-17(9-34-22)21(32)29-16-7-28-31(2)20(16)18-4-3-15(27)14(26)8-33-18/h5-7,9-10,14-15,18H,3-4,8,27H2,1-2H3,(H,29,32)/t10-,14+,15+,18-/m0/s1
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0.00200n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393426
PNG
(N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...)
Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2c(F)cc3[C@H](O)CCOc3c2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
Show InChI InChI=1S/C23H24F3N5O4S/c1-31-20(17-3-2-13(27)12(25)8-35-17)14(7-28-31)29-22(33)15-9-36-23(30-15)18-11(24)6-10-16(32)4-5-34-21(10)19(18)26/h6-7,9,12-13,16-17,32H,2-5,8,27H2,1H3,(H,29,33)/t12-,13-,16-,17+/m1/s1
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0.00400n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393434
PNG
(N-(5-((2S,5R,6R,7S)-5-amino-6- fluoro-7-methyloxep...)
Show SMILES C[C@@H]1O[C@@H](CC[C@@H](N)[C@H]1F)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C
Show InChI InChI=1S/C21H22F3N5O2S/c1-10-18(24)13(25)6-7-16(31-10)19-14(8-26-29(19)2)27-20(30)15-9-32-21(28-15)17-11(22)4-3-5-12(17)23/h3-5,8-10,13,16,18H,6-7,25H2,1-2H3,(H,27,30)/t10-,13+,16-,18-/m0/s1
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0.00500n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393431
PNG
(N-(5-((2S,5R,6S,7R)-5-amino-6- methoxy-7-methyloxe...)
Show SMILES CO[C@H]1[C@H](N)CC[C@H](O[C@@H]1C)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C
Show InChI InChI=1S/C22H25F2N5O3S/c1-11-20(31-3)14(25)7-8-17(32-11)19-15(9-26-29(19)2)27-21(30)16-10-33-22(28-16)18-12(23)5-4-6-13(18)24/h4-6,9-11,14,17,20H,7-8,25H2,1-3H3,(H,27,30)/t11-,14-,17+,20-/m1/s1
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0.00600n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393421
PNG
(N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...)
Show SMILES C[C@@H](F)c1cc(F)c(-c2nc(cs2)C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(F)c1
Show InChI InChI=1S/C22H23F4N5O2S/c1-10(23)11-5-12(24)19(13(25)6-11)22-30-17(9-34-22)21(32)29-16-7-28-31(2)20(16)18-4-3-15(27)14(26)8-33-18/h5-7,9-10,14-15,18H,3-4,8,27H2,1-2H3,(H,29,32)/t10-,14-,15-,18+/m1/s1
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0.0150n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393425
PNG
(N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...)
Show SMILES Cc1cnc(cn1)-c1nc(cs1)C(=O)Nc1cnn(C)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
Show InChI InChI=1S/C19H22FN7O2S/c1-10-5-23-14(6-22-10)19-26-15(9-30-19)18(28)25-13-7-24-27(2)17(13)16-4-3-12(21)11(20)8-29-16/h5-7,9,11-12,16H,3-4,8,21H2,1-2H3,(H,25,28)/t11-,12-,16+/m1/s1
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0.0180n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393424
PNG
(N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...)
Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2cc3[nH]ncc3cc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
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0.0190n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393435
PNG
(N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...)
Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2cn3ccnc3cn2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
Show InChI InChI=1S/C20H21FN8O2S/c1-28-18(16-3-2-12(22)11(21)9-31-16)13(6-25-28)26-19(30)15-10-32-20(27-15)14-8-29-5-4-23-17(29)7-24-14/h4-8,10-12,16H,2-3,9,22H2,1H3,(H,26,30)/t11-,12-,16+/m1/s1
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0.0250n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393427
PNG
(N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...)
Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2n[nH]c3CCCc23)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
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0.0300n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393430
PNG
(N-[5-[(2S,5R,6S,7S)-5-amino-6- methoxy-7-methyl-ox...)
Show SMILES CO[C@H]1[C@H](N)CC[C@H](O[C@H]1C)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C
Show InChI InChI=1S/C22H25F2N5O3S/c1-11-20(31-3)14(25)7-8-17(32-11)19-15(9-26-29(19)2)27-21(30)16-10-33-22(28-16)18-12(23)5-4-6-13(18)24/h4-6,9-11,14,17,20H,7-8,25H2,1-3H3,(H,27,30)/t11-,14+,17-,20+/m0/s1
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0.0320n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393423
PNG
(N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...)
Show SMILES COc1cc(F)c(cc1Cl)-c1nc(cs1)C(=O)Nc1cnn(C)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
Show InChI InChI=1S/C21H22ClF2N5O3S/c1-29-19(17-4-3-14(25)13(24)8-32-17)15(7-26-29)27-20(30)16-9-33-21(28-16)10-5-11(22)18(31-2)6-12(10)23/h5-7,9,13-14,17H,3-4,8,25H2,1-2H3,(H,27,30)/t13-,14-,17+/m1/s1
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0.0420n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393432
PNG
(N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...)
Show SMILES COc1cnc(-c2nc(cs2)C(=O)Nc2cnn(C)c2[C@@H]2CC[C@@H](N)[C@H](F)CO2)c(C)c1
Show InChI InChI=1S/C21H25FN6O3S/c1-11-6-12(30-3)7-24-18(11)21-27-16(10-32-21)20(29)26-15-8-25-28(2)19(15)17-5-4-14(23)13(22)9-31-17/h6-8,10,13-14,17H,4-5,9,23H2,1-3H3,(H,26,29)/t13-,14-,17+/m1/s1
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0.0430n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393429
PNG
(N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-(...)
Show SMILES N[C@@H]1CC[C@H](OC[C@H]1F)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1CC(F)F
Show InChI InChI=1S/C21H20F5N5O2S/c22-10-2-1-3-11(23)18(10)21-30-15(9-34-21)20(32)29-14-6-28-31(7-17(25)26)19(14)16-5-4-13(27)12(24)8-33-16/h1-3,6,9,12-13,16-17H,4-5,7-8,27H2,(H,29,32)/t12-,13-,16+/m1/s1
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0.0470n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393436
PNG
(N-[5-[(2S,5R,6S,7S)-5-amino-6- fluoro-7-methyl-oxe...)
Show SMILES C[C@@H]1O[C@@H](CC[C@@H](N)[C@@H]1F)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C
Show InChI InChI=1S/C21H22F3N5O2S/c1-10-18(24)13(25)6-7-16(31-10)19-14(8-26-29(19)2)27-20(30)15-9-32-21(28-15)17-11(22)4-3-5-12(17)23/h3-5,8-10,13,16,18H,6-7,25H2,1-2H3,(H,27,30)/t10-,13+,16-,18+/m0/s1
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0.0510n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393420
PNG
(N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...)
Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2cnccn2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
Show InChI InChI=1S/C18H20FN7O2S/c1-26-16(15-3-2-11(20)10(19)8-28-15)12(7-23-26)24-17(27)14-9-29-18(25-14)13-6-21-4-5-22-13/h4-7,9-11,15H,2-3,8,20H2,1H3,(H,24,27)/t10-,11-,15+/m1/s1
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0.0950n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393422
PNG
(N-(5-((2R,5S,6R,7S)-5-amino-6- methoxy-7-methyloxe...)
Show SMILES CO[C@@H]1[C@@H](N)CC[C@@H](O[C@H]1C)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C
Show InChI InChI=1S/C22H25F2N5O3S/c1-11-20(31-3)14(25)7-8-17(32-11)19-15(9-26-29(19)2)27-21(30)16-10-33-22(28-16)18-12(23)5-4-6-13(18)24/h4-6,9-11,14,17,20H,7-8,25H2,1-3H3,(H,27,30)/t11-,14-,17+,20-/m0/s1
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0.100n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393419
PNG
(N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...)
Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2ccc3OCCc3c2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
Show InChI InChI=1S/C22H24FN5O3S/c1-28-20(19-5-3-15(24)14(23)10-31-19)16(9-25-28)26-21(29)17-11-32-22(27-17)13-2-4-18-12(8-13)6-7-30-18/h2,4,8-9,11,14-15,19H,3,5-7,10,24H2,1H3,(H,26,29)/t14-,15-,19+/m1/s1
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0.104n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393417
PNG
(N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...)
Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2c(O)cccc2F)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
Show InChI InChI=1S/C20H21F2N5O3S/c1-27-18(16-6-5-12(23)11(22)8-30-16)13(7-24-27)25-19(29)14-9-31-20(26-14)17-10(21)3-2-4-15(17)28/h2-4,7,9,11-12,16,28H,5-6,8,23H2,1H3,(H,25,29)/t11-,12-,16+/m1/s1
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0.121n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393428
PNG
(N-[5-[(2R,5S,6R)-5-amino-6- fluoro-oxepan-2-yl]-1-...)
Show SMILES N[C@H]1CC[C@@H](OC[C@@H]1F)c1c(NC(=O)c2ccc(F)c(n2)-c2c(F)cccc2F)cnn1C1CC1
Show InChI InChI=1S/C24H23F4N5O2/c25-13-2-1-3-14(26)21(13)22-15(27)6-8-18(31-22)24(34)32-19-10-30-33(12-4-5-12)23(19)20-9-7-17(29)16(28)11-35-20/h1-3,6,8,10,12,16-17,20H,4-5,7,9,11,29H2,(H,32,34)/t16-,17-,20+/m0/s1
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0.173n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393418
PNG
(N-[5-[(2R,5S,6R)-5-amino-6- fluoro-oxepan-2-yl]-1-...)
Show SMILES N[C@H]1CCC(OC[C@@H]1F)c1c(NC(=O)c2csc(n2)-c2c(F)cccc2F)cnn1C1CC1
Show InChI InChI=1S/C22H22F3N5O2S/c23-12-2-1-3-13(24)19(12)22-29-17(10-33-22)21(31)28-16-8-27-30(11-4-5-11)20(16)18-7-6-15(26)14(25)9-32-18/h1-3,8,10-11,14-15,18H,4-7,9,26H2,(H,28,31)/t14-,15-,18?/m0/s1
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0.180n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393440
PNG
(N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1H-...)
Show SMILES Cc1cccnc1-c1nc(cs1)C(=O)Nc1cn[nH]c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
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0.777n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393441
PNG
(N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1H-...)
Show SMILES N[C@@H]1CC[C@H](OC[C@H]1F)c1[nH]ncc1NC(=O)c1csc(n1)-c1c(F)cccc1F
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0.958n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393439
PNG
(N-(5-((2R,5S,6R)-5-amino-6- fluorooxepan-2-yl)-1H-...)
Show SMILES N[C@H]1CC[C@@H](OC[C@@H]1F)c1[nH]ncc1NC(=O)c1csc(n1)-c1ccccn1
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1.10n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393438
PNG
(N-(5-((2R,5S,6R)-5-amino-6- fluorooxepan-2-yl)-1H-...)
Show SMILES N[C@H]1CC[C@@H](OC[C@@H]1F)c1[nH]ncc1NC(=O)c1csc(n1)-c1c(F)cccc1F
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1.48n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393433
PNG
(N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...)
Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2cccc3cccnc23)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
Show InChI InChI=1S/C23H23FN6O2S/c1-30-21(19-8-7-16(25)15(24)11-32-19)17(10-27-30)28-22(31)18-12-33-23(29-18)14-6-2-4-13-5-3-9-26-20(13)14/h2-6,9-10,12,15-16,19H,7-8,11,25H2,1H3,(H,28,31)/t15-,16-,19+/m1/s1
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1.79n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
Serine/threonine-protein kinase pim-1


(Homo sapiens (Human))
BDBM393437
PNG
(N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...)
Show SMILES Cn1ncc(NC(=O)c2csc(n2)-c2cn3ccncc3n2)c1[C@@H]1CC[C@@H](N)[C@H](F)CO1
Show InChI InChI=1S/C20H21FN8O2S/c1-28-18(16-3-2-12(22)11(21)9-31-16)13(6-24-28)26-19(30)15-10-32-20(27-15)14-8-29-5-4-23-7-17(29)25-14/h4-8,10-12,16H,2-3,9,22H2,1H3,(H,26,30)/t11-,12-,16+/m1/s1
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32.8n/an/an/an/an/an/an/an/a



Genentech Inc

US Patent


Assay Description
Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ...


US Patent US9963446 (2018)


BindingDB Entry DOI: 10.7270/Q22B91B0
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%