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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393298 (N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.00200 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393426 (N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.00400 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393434 (N-(5-((2S,5R,6R,7S)-5-amino-6- fluoro-7-methyloxep...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.00500 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393431 (N-(5-((2S,5R,6S,7R)-5-amino-6- methoxy-7-methyloxe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.00600 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393421 (N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.0150 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393425 (N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.0180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393424 (N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.0190 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393435 (N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.0250 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393427 (N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.0300 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393430 (N-[5-[(2S,5R,6S,7S)-5-amino-6- methoxy-7-methyl-ox...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.0320 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393423 (N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.0420 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393432 (N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.0430 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393429 (N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-(...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.0470 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393436 (N-[5-[(2S,5R,6S,7S)-5-amino-6- fluoro-7-methyl-oxe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.0510 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393420 (N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.0950 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393422 (N-(5-((2R,5S,6R,7S)-5-amino-6- methoxy-7-methyloxe...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.100 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393419 (N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.104 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393417 (N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.121 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393428 (N-[5-[(2R,5S,6R)-5-amino-6- fluoro-oxepan-2-yl]-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.173 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393418 (N-[5-[(2R,5S,6R)-5-amino-6- fluoro-oxepan-2-yl]-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.180 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393440 (N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.777 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393441 (N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 0.958 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393439 (N-(5-((2R,5S,6R)-5-amino-6- fluorooxepan-2-yl)-1H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 1.10 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393438 (N-(5-((2R,5S,6R)-5-amino-6- fluorooxepan-2-yl)-1H-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 1.48 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393433 (N-[5-[(2S,5R,6S)-5-amino-6- fluoro-oxepan-2-yl]-1-...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 1.79 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Serine/threonine-protein kinase pim-1 (Homo sapiens (Human)) | BDBM393437 (N-(5-((2S,5R,6S)-5-amino-6- fluorooxepan-2-yl)-1-m...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | PC cid PC sid UniChem | US Patent | 32.8 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Genentech Inc US Patent | Assay Description Determination of the Pim kinase activity of a Formula I compound is possible by a number of direct and indirect detection methods. Certain exemplary ... | US Patent US9963446 (2018) BindingDB Entry DOI: 10.7270/Q22B91B0 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
