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Patent code US9969687

Compile Data Set for Download or QSAR
Found 122 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393520
PNG
(US9969687, Compound 183)
Show SMILES COc1ncccc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)14-7-9-15(10-8-14)34(31,32)27-17-12-11-16(25)19-20(17)23(30)28(22(19)29)18-6-5-13-26-21(18)33-4/h5-13,27H,1-4H3
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3n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393561
PNG
(US9969687, Compound 232)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1ccsc1C#N
Show InChI InChI=1S/C23H18ClN3O4S2/c1-23(2,3)13-4-6-14(7-5-13)33(30,31)26-16-9-8-15(24)19-20(16)22(29)27(21(19)28)17-10-11-32-18(17)12-25/h4-11,26H,1-3H3
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3n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393572
PNG
(US9969687, Compound 244)
Show SMILES Cc1cnccc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O4S/c1-14-13-26-12-11-19(14)28-22(29)20-17(25)9-10-18(21(20)23(28)30)27-33(31,32)16-7-5-15(6-8-16)24(2,3)4/h5-13,27H,1-4H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393600
PNG
(US9969687, Compound 281)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1ccc[nH]c1=O
Show InChI InChI=1S/C23H20ClN3O5S/c1-23(2,3)13-6-8-14(9-7-13)33(31,32)26-16-11-10-15(24)18-19(16)22(30)27(21(18)29)17-5-4-12-25-20(17)28/h4-12,26H,1-3H3,(H,25,28)
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393530
PNG
(US9969687, Compound 194)
Show SMILES COc1c(ccc[n+]1[O-])N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O6S/c1-24(2,3)14-7-9-15(10-8-14)35(32,33)26-17-12-11-16(25)19-20(17)22(30)28(21(19)29)18-6-5-13-27(31)23(18)34-4/h5-13,26H,1-4H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393557
PNG
(US9969687, Compound 228)
Show SMILES Cc1cccc(n1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O4S/c1-14-6-5-7-19(26-14)28-22(29)20-17(25)12-13-18(21(20)23(28)30)27-33(31,32)16-10-8-15(9-11-16)24(2,3)4/h5-13,27H,1-4H3
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6n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393559
PNG
(US9969687, Compound 230)
Show SMILES COc1ccc(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c(OC)n1
Show InChI InChI=1S/C25H24ClN3O6S/c1-25(2,3)14-6-8-15(9-7-14)36(32,33)28-17-11-10-16(26)20-21(17)24(31)29(23(20)30)18-12-13-19(34-4)27-22(18)35-5/h6-13,28H,1-5H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393553
PNG
(US9969687, Compound 224)
Show SMILES Cc1ccc(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c(C)n1
Show InChI InChI=1S/C25H24ClN3O4S/c1-14-6-13-20(15(2)27-14)29-23(30)21-18(26)11-12-19(22(21)24(29)31)28-34(32,33)17-9-7-16(8-10-17)25(3,4)5/h6-13,28H,1-5H3
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6n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393569
PNG
(US9969687, Compound 241)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3c(F)ccc[n+]3[O-])C(=O)c12
Show InChI InChI=1S/C24H21ClFN3O5S/c1-24(2,3)14-6-8-15(9-7-14)35(33,34)27-18-11-10-16(25)20-21(18)23(31)28(22(20)30)13-19-17(26)5-4-12-29(19)32/h4-12,27H,13H2,1-3H3
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7n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393566
PNG
(US9969687, Compound 237)
Show SMILES COc1nccc(C)c1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H24ClN3O5S/c1-14-12-13-27-22(34-5)21(14)29-23(30)19-17(26)10-11-18(20(19)24(29)31)28-35(32,33)16-8-6-15(7-9-16)25(2,3)4/h6-13,28H,1-5H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393534
PNG
(US9969687, Compound 199)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3cccc[n+]3[O-])C(=O)c12
Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)15-7-9-17(10-8-15)34(32,33)26-19-12-11-18(25)20-21(19)23(30)27(22(20)29)14-16-6-4-5-13-28(16)31/h4-13,26H,14H2,1-3H3
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Norgine B.V.

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Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393606
PNG
(US9969687, Compound 287)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cccnc1C(O)=O
Show InChI InChI=1S/C24H20ClN3O6S/c1-24(2,3)13-6-8-14(9-7-13)35(33,34)27-16-11-10-15(25)18-19(16)22(30)28(21(18)29)17-5-4-12-26-20(17)23(31)32/h4-12,27H,1-3H3,(H,31,32)
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Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393585
PNG
(US9969687, Compound 261)
Show SMILES COc1ncc(C)cc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H24ClN3O5S/c1-14-12-19(22(34-5)27-13-14)29-23(30)20-17(26)10-11-18(21(20)24(29)31)28-35(32,33)16-8-6-15(7-9-16)25(2,3)4/h6-13,28H,1-5H3
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Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393528
PNG
(US9969687, Compound 192)
Show SMILES Cn1cncc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C22H21ClN4O4S/c1-22(2,3)13-5-7-14(8-6-13)32(30,31)25-16-10-9-15(23)18-19(16)21(29)27(20(18)28)17-11-24-12-26(17)4/h5-12,25H,1-4H3
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Norgine B.V.

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Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393552
PNG
(US9969687, Compound 222)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1ccccn1
Show InChI InChI=1S/C23H20ClN3O4S/c1-23(2,3)14-7-9-15(10-8-14)32(30,31)26-17-12-11-16(24)19-20(17)22(29)27(21(19)28)18-6-4-5-13-25-18/h4-13,26H,1-3H3
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Norgine B.V.

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Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393603
PNG
(US9969687, Compound 284)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3ccc[nH]c3=O)C(=O)c12
Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)15-6-8-16(9-7-15)34(32,33)27-18-11-10-17(25)19-20(18)23(31)28(22(19)30)13-14-5-4-12-26-21(14)29/h4-12,27H,13H2,1-3H3,(H,26,29)
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Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393516
PNG
(US9969687, Compound 175)
Show SMILES Cc1ncccc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O4S/c1-14-19(6-5-13-26-14)28-22(29)20-17(25)11-12-18(21(20)23(28)30)27-33(31,32)16-9-7-15(8-10-16)24(2,3)4/h5-13,27H,1-4H3
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Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393567
PNG
(US9969687, Compound 238)
Show SMILES COc1ccc(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c(C)n1
Show InChI InChI=1S/C25H24ClN3O5S/c1-14-19(12-13-20(27-14)34-5)29-23(30)21-17(26)10-11-18(22(21)24(29)31)28-35(32,33)16-8-6-15(7-9-16)25(2,3)4/h6-13,28H,1-5H3
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Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393517
PNG
(US9969687, Compound 176)
Show SMILES Cc1c(ccc[n+]1[O-])N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O5S/c1-14-19(6-5-13-27(14)31)28-22(29)20-17(25)11-12-18(21(20)23(28)30)26-34(32,33)16-9-7-15(8-10-16)24(2,3)4/h5-13,26H,1-4H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393609
PNG
(US9969687, Compound 290)
Show SMILES CCOC(=O)c1c(ccc[n+]1[O-])N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C26H24ClN3O7S/c1-5-37-25(33)22-19(7-6-14-29(22)34)30-23(31)20-17(27)12-13-18(21(20)24(30)32)28-38(35,36)16-10-8-15(9-11-16)26(2,3)4/h6-14,28H,5H2,1-4H3
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14n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393605
PNG
(US9969687, Compound 286)
Show SMILES CCOC(=O)c1ncccc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C26H24ClN3O6S/c1-5-36-25(33)22-19(7-6-14-28-22)30-23(31)20-17(27)12-13-18(21(20)24(30)32)29-37(34,35)16-10-8-15(9-11-16)26(2,3)4/h6-14,29H,5H2,1-4H3
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14n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393610
PNG
(US9969687, Compound 291)
Show SMILES COC(=O)c1cc(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)n(C)n1
Show InChI InChI=1S/C24H23ClN4O6S/c1-24(2,3)13-6-8-14(9-7-13)36(33,34)27-16-11-10-15(25)19-20(16)22(31)29(21(19)30)18-12-17(23(32)35-5)26-28(18)4/h6-12,27H,1-5H3
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US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393541
PNG
(US9969687, Compound 208)
Show SMILES Cc1ccncc1CN1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H24ClN3O4S/c1-15-11-12-27-13-16(15)14-29-23(30)21-19(26)9-10-20(22(21)24(29)31)28-34(32,33)18-7-5-17(6-8-18)25(2,3)4/h5-13,28H,14H2,1-4H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393611
PNG
(US9969687, Compound 292)
Show SMILES COC(=O)c1cc(nn1C)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H23ClN4O6S/c1-24(2,3)13-6-8-14(9-7-13)36(33,34)27-16-11-10-15(25)19-20(16)22(31)29(21(19)30)18-12-17(23(32)35-5)28(4)26-18/h6-12,27H,1-5H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393536
PNG
(US9969687, Compound 201)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3ccncc3)C(=O)c12
Show InChI InChI=1S/C24H22ClN3O4S/c1-24(2,3)16-4-6-17(7-5-16)33(31,32)27-19-9-8-18(25)20-21(19)23(30)28(22(20)29)14-15-10-12-26-13-11-15/h4-13,27H,14H2,1-3H3
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US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393597
PNG
(US9969687, Compound 278)
Show SMILES COc1cncc(c1)N1C(=O)c2c(C1=O)c(ccc2NS(=O)(=O)c1ccc(cc1)C(C)(C)C)C#N
Show InChI InChI=1S/C25H22N4O5S/c1-25(2,3)16-6-8-19(9-7-16)35(32,33)28-20-10-5-15(12-26)21-22(20)24(31)29(23(21)30)17-11-18(34-4)14-27-13-17/h5-11,13-14,28H,1-4H3
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US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393598
PNG
(US9969687, Compound 279)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(C#N)c2C(=O)N(Cc3ccccn3)C(=O)c12
Show InChI InChI=1S/C25H22N4O4S/c1-25(2,3)17-8-10-19(11-9-17)34(32,33)28-20-12-7-16(14-26)21-22(20)24(31)29(23(21)30)15-18-6-4-5-13-27-18/h4-13,28H,15H2,1-3H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393588
PNG
(US9969687, Compound 264)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1ccncc1
Show InChI InChI=1S/C23H20ClN3O4S/c1-23(2,3)14-4-6-16(7-5-14)32(30,31)26-18-9-8-17(24)19-20(18)22(29)27(21(19)28)15-10-12-25-13-11-15/h4-13,26H,1-3H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393580
PNG
(US9969687, Compound 256)
Show SMILES Cc1cnc(C#N)c(c1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H21ClN4O4S/c1-14-11-20(19(12-27)28-13-14)30-23(31)21-17(26)9-10-18(22(21)24(30)32)29-35(33,34)16-7-5-15(6-8-16)25(2,3)4/h5-11,13,29H,1-4H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393602
PNG
(US9969687, Compound 283)
Show SMILES Cc1cc(C)c(CN2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c(=O)[nH]1
Show InChI InChI=1S/C26H26ClN3O5S/c1-14-12-15(2)28-23(31)18(14)13-30-24(32)21-19(27)10-11-20(22(21)25(30)33)29-36(34,35)17-8-6-16(7-9-17)26(3,4)5/h6-12,29H,13H2,1-5H3,(H,28,31)
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393581
PNG
(US9969687, Compound 257)
Show SMILES CCc1c(OC)cncc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C26H26ClN3O5S/c1-6-17-20(13-28-14-21(17)35-5)30-24(31)22-18(27)11-12-19(23(22)25(30)32)29-36(33,34)16-9-7-15(8-10-16)26(2,3)4/h7-14,29H,6H2,1-5H3
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US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393562
PNG
(US9969687, Compound 233)
Show SMILES Cc1cccc(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)[n+]1[O-]
Show InChI InChI=1S/C24H22ClN3O5S/c1-14-6-5-7-19(28(14)31)27-22(29)20-17(25)12-13-18(21(20)23(27)30)26-34(32,33)16-10-8-15(9-11-16)24(2,3)4/h5-13,26H,1-4H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393529
PNG
(US9969687, Compound 193)
Show SMILES Cn1ccc(CN2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)n1
Show InChI InChI=1S/C23H23ClN4O4S/c1-23(2,3)14-5-7-16(8-6-14)33(31,32)26-18-10-9-17(24)19-20(18)22(30)28(21(19)29)13-15-11-12-27(4)25-15/h5-12,26H,13H2,1-4H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393584
PNG
(US9969687, Compound 260)
Show SMILES COc1ccc(nc1C)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H24ClN3O5S/c1-14-19(34-5)12-13-20(27-14)29-23(30)21-17(26)10-11-18(22(21)24(29)31)28-35(32,33)16-8-6-15(7-9-16)25(2,3)4/h6-13,28H,1-5H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393545
PNG
(US9969687, Compound 213)
Show SMILES Cc1cc[n+]([O-])cc1CN1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H24ClN3O5S/c1-15-11-12-28(32)13-16(15)14-29-23(30)21-19(26)9-10-20(22(21)24(29)31)27-35(33,34)18-7-5-17(6-8-18)25(2,3)4/h5-13,27H,14H2,1-4H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393522
PNG
(US9969687, Compound 185)
Show SMILES Cc1ccncc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O4S/c1-14-11-12-26-13-19(14)28-22(29)20-17(25)9-10-18(21(20)23(28)30)27-33(31,32)16-7-5-15(6-8-16)24(2,3)4/h5-13,27H,1-4H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393509
PNG
(US9969687, Compound 144)
Show SMILES Cn1nccc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C22H21ClN4O4S/c1-22(2,3)13-5-7-14(8-6-13)32(30,31)25-16-10-9-15(23)18-19(16)21(29)27(20(18)28)17-11-12-24-26(17)4/h5-12,25H,1-4H3
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US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393607
PNG
(US9969687, Compound 288)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1ccsc1C(O)=O
Show InChI InChI=1S/C23H19ClN2O6S2/c1-23(2,3)12-4-6-13(7-5-12)34(31,32)25-15-9-8-14(24)17-18(15)21(28)26(20(17)27)16-10-11-33-19(16)22(29)30/h4-11,25H,1-3H3,(H,29,30)
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US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393568
PNG
(US9969687, Compound 239)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3ncccc3F)C(=O)c12
Show InChI InChI=1S/C24H21ClFN3O4S/c1-24(2,3)14-6-8-15(9-7-14)34(32,33)28-18-11-10-16(25)20-21(18)23(31)29(22(20)30)13-19-17(26)5-4-12-27-19/h4-12,28H,13H2,1-3H3
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US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393555
PNG
(US9969687, Compound 226)
Show SMILES Cc1ccc(nc1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O4S/c1-14-5-12-19(26-13-14)28-22(29)20-17(25)10-11-18(21(20)23(28)30)27-33(31,32)16-8-6-15(7-9-16)24(2,3)4/h5-13,27H,1-4H3
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US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393601
PNG
(US9969687, Compound 282)
Show SMILES Cn1cc(ccc1=O)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)14-5-8-16(9-6-14)34(32,33)26-18-11-10-17(25)20-21(18)23(31)28(22(20)30)15-7-12-19(29)27(4)13-15/h5-13,26H,1-4H3
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US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393521
PNG
(US9969687, Compound 184)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cnccn1
Show InChI InChI=1S/C22H19ClN4O4S/c1-22(2,3)13-4-6-14(7-5-13)32(30,31)26-16-9-8-15(23)18-19(16)21(29)27(20(18)28)17-12-24-10-11-25-17/h4-12,26H,1-3H3
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US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393587
PNG
(US9969687, Compound 263)
Show SMILES Cc1cnc(C)c(c1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H24ClN3O4S/c1-14-12-20(15(2)27-13-14)29-23(30)21-18(26)10-11-19(22(21)24(29)31)28-34(32,33)17-8-6-16(7-9-17)25(3,4)5/h6-13,28H,1-5H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393589
PNG
(US9969687, Compound 266)
Show SMILES CCc1c(OC)c[n+]([O-])cc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C26H26ClN3O6S/c1-6-17-20(13-29(33)14-21(17)36-5)30-24(31)22-18(27)11-12-19(23(22)25(30)32)28-37(34,35)16-9-7-15(8-10-16)26(2,3)4/h7-14,28H,6H2,1-5H3
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US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393549
PNG
(US9969687, Compound 218)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cccnc1F
Show InChI InChI=1S/C23H19ClFN3O4S/c1-23(2,3)13-6-8-14(9-7-13)33(31,32)27-16-11-10-15(24)18-19(16)22(30)28(21(18)29)17-5-4-12-26-20(17)25/h4-12,27H,1-3H3
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26n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393494
PNG
(US9969687, Compound 64)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3cccnc3)C(=O)c12
Show InChI InChI=1S/C24H22ClN3O4S/c1-24(2,3)16-6-8-17(9-7-16)33(31,32)27-19-11-10-18(25)20-21(19)23(30)28(22(20)29)14-15-5-4-12-26-13-15/h4-13,27H,14H2,1-3H3
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27n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393593
PNG
(US9969687, Compound 272)
Show SMILES Cc1c[n+]([O-])ccc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O5S/c1-14-13-27(31)12-11-19(14)28-22(29)20-17(25)9-10-18(21(20)23(28)30)26-34(32,33)16-7-5-15(6-8-16)24(2,3)4/h5-13,26H,1-4H3
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29n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393539
PNG
(US9969687, Compound 204)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3ncccn3)C(=O)c12
Show InChI InChI=1S/C23H21ClN4O4S/c1-23(2,3)14-5-7-15(8-6-14)33(31,32)27-17-10-9-16(24)19-20(17)22(30)28(21(19)29)13-18-25-11-4-12-26-18/h4-12,27H,13H2,1-3H3
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30n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393550
PNG
(US9969687, Compound 219)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1ccc(F)cn1
Show InChI InChI=1S/C23H19ClFN3O4S/c1-23(2,3)13-4-7-15(8-5-13)33(31,32)27-17-10-9-16(24)19-20(17)22(30)28(21(19)29)18-11-6-14(25)12-26-18/h4-12,27H,1-3H3
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30n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393556
PNG
(US9969687, Compound 227)
Show SMILES Cc1ccc(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c(C)[n+]1[O-]
Show InChI InChI=1S/C25H24ClN3O5S/c1-14-6-13-20(15(2)29(14)32)28-23(30)21-18(26)11-12-19(22(21)24(28)31)27-35(33,34)17-9-7-16(8-10-17)25(3,4)5/h6-13,27H,1-5H3
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32n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393565
PNG
(US9969687, Compound 236)
Show SMILES Cc1ccc(nn1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C23H21ClN4O4S/c1-13-5-12-18(26-25-13)28-21(29)19-16(24)10-11-17(20(19)22(28)30)27-33(31,32)15-8-6-14(7-9-15)23(2,3)4/h5-12,27H,1-4H3
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32n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393527
PNG
(US9969687, Compound 191)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3ccccn3)C(=O)c12
Show InChI InChI=1S/C24H22ClN3O4S/c1-24(2,3)15-7-9-17(10-8-15)33(31,32)27-19-12-11-18(25)20-21(19)23(30)28(22(20)29)14-16-6-4-5-13-26-16/h4-13,27H,14H2,1-3H3
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33n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393524
PNG
(US9969687, Compound 189)
Show SMILES COc1cc[n+]([O-])cc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O6S/c1-24(2,3)14-5-7-15(8-6-14)35(32,33)26-17-10-9-16(25)20-21(17)23(30)28(22(20)29)18-13-27(31)12-11-19(18)34-4/h5-13,26H,1-4H3
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34n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393592
PNG
(US9969687, Compound 271)
Show SMILES CCOc1ccncc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H24ClN3O5S/c1-5-34-20-12-13-27-14-19(20)29-23(30)21-17(26)10-11-18(22(21)24(29)31)28-35(32,33)16-8-6-15(7-9-16)25(2,3)4/h6-14,28H,5H2,1-4H3
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35n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393502
PNG
(US9969687, Compound 119)
Show SMILES COc1ccncc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)14-5-7-15(8-6-14)34(31,32)27-17-10-9-16(25)20-21(17)23(30)28(22(20)29)18-13-26-12-11-19(18)33-4/h5-13,27H,1-4H3
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35n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393540
PNG
(US9969687, Compound 207)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cccc(n1)C#N
Show InChI InChI=1S/C24H19ClN4O4S/c1-24(2,3)14-7-9-16(10-8-14)34(32,33)28-18-12-11-17(25)20-21(18)23(31)29(22(20)30)19-6-4-5-15(13-26)27-19/h4-12,28H,1-3H3
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36n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393548
PNG
(US9969687, Compound 217)
Show SMILES Cc1cnc(s1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C22H20ClN3O4S2/c1-12-11-24-21(31-12)26-19(27)17-15(23)9-10-16(18(17)20(26)28)25-32(29,30)14-7-5-13(6-8-14)22(2,3)4/h5-11,25H,1-4H3
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39n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393533
PNG
(US9969687, Compound 197)
Show SMILES CCOc1cc(c[n+]([O-])c1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H24ClN3O6S/c1-5-35-17-12-16(13-28(32)14-17)29-23(30)21-19(26)10-11-20(22(21)24(29)31)27-36(33,34)18-8-6-15(7-9-18)25(2,3)4/h6-14,27H,5H2,1-4H3
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40n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393531
PNG
(US9969687, Compound 195)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3cncc(c3)C#N)C(=O)c12
Show InChI InChI=1S/C25H21ClN4O4S/c1-25(2,3)17-4-6-18(7-5-17)35(33,34)29-20-9-8-19(26)21-22(20)24(32)30(23(21)31)14-16-10-15(11-27)12-28-13-16/h4-10,12-13,29H,14H2,1-3H3
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42n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393490
PNG
(US9969687, Compound 43)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cccnc1
Show InChI InChI=1S/C23H20ClN3O4S/c1-23(2,3)14-6-8-16(9-7-14)32(30,31)26-18-11-10-17(24)19-20(18)22(29)27(21(19)28)15-5-4-12-25-13-15/h4-13,26H,1-3H3
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42n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393551
PNG
(US9969687, Compound 220)
Show SMILES Cc1cncc(n1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C23H21ClN4O4S/c1-13-11-25-12-18(26-13)28-21(29)19-16(24)9-10-17(20(19)22(28)30)27-33(31,32)15-7-5-14(6-8-15)23(2,3)4/h5-12,27H,1-4H3
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42n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393513
PNG
(US9969687, Compound 153)
Show SMILES Cn1cnc(c1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C22H21ClN4O4S/c1-22(2,3)13-5-7-14(8-6-13)32(30,31)25-16-10-9-15(23)18-19(16)21(29)27(20(18)28)17-11-26(4)12-24-17/h5-12,25H,1-4H3
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43n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393563
PNG
(US9969687, Compound 234)
Show SMILES Cn1nnc(n1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C20H19ClN6O4S/c1-20(2,3)11-5-7-12(8-6-11)32(30,31)24-14-10-9-13(21)15-16(14)18(29)27(17(15)28)19-22-25-26(4)23-19/h5-10,24H,1-4H3
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43n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393583
PNG
(US9969687, Compound 259)
Show SMILES Cc1ccc(CN2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)[n+]([O-])c1
Show InChI InChI=1S/C25H24ClN3O5S/c1-15-5-8-17(29(32)13-15)14-28-23(30)21-19(26)11-12-20(22(21)24(28)31)27-35(33,34)18-9-6-16(7-10-18)25(2,3)4/h5-13,27H,14H2,1-4H3
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45n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393537
PNG
(US9969687, Compound 202)
Show SMILES COc1cccnc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)14-7-9-15(10-8-14)34(31,32)27-17-12-11-16(25)19-20(17)23(30)28(22(19)29)21-18(33-4)6-5-13-26-21/h5-13,27H,1-4H3
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49n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393547
PNG
(US9969687, Compound 216)
Show SMILES Cc1ccnc(n1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C23H21ClN4O4S/c1-13-11-12-25-22(26-13)28-20(29)18-16(24)9-10-17(19(18)21(28)30)27-33(31,32)15-7-5-14(6-8-15)23(2,3)4/h5-12,27H,1-4H3
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49n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393594
PNG
(US9969687, Compound 274)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cccc[n+]1[O-]
Show InChI InChI=1S/C23H20ClN3O5S/c1-23(2,3)14-7-9-15(10-8-14)33(31,32)25-17-12-11-16(24)19-20(17)22(29)27(21(19)28)18-6-4-5-13-26(18)30/h4-13,25H,1-3H3
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Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393554
PNG
(US9969687, Compound 225)
Show SMILES Cc1ccnc(c1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O4S/c1-14-11-12-26-19(13-14)28-22(29)20-17(25)9-10-18(21(20)23(28)30)27-33(31,32)16-7-5-15(6-8-16)24(2,3)4/h5-13,27H,1-4H3
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51n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393574
PNG
(US9969687, Compound 247)
Show SMILES COc1ncccc1CN1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H24ClN3O5S/c1-25(2,3)16-7-9-17(10-8-16)35(32,33)28-19-12-11-18(26)20-21(19)24(31)29(23(20)30)14-15-6-5-13-27-22(15)34-4/h5-13,28H,14H2,1-4H3
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51n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393546
PNG
(US9969687, Compound 214)
Show SMILES Cc1cc(c[n+]([O-])c1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O5S/c1-14-11-16(13-27(31)12-14)28-22(29)20-18(25)9-10-19(21(20)23(28)30)26-34(32,33)17-7-5-15(6-8-17)24(2,3)4/h5-13,26H,1-4H3
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53n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393573
PNG
(US9969687, Compound 245)
Show SMILES COc1c[n+]([O-])cc(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c1C
Show InChI InChI=1S/C25H24ClN3O6S/c1-14-19(12-28(32)13-20(14)35-5)29-23(30)21-17(26)10-11-18(22(21)24(29)31)27-36(33,34)16-8-6-15(7-9-16)25(2,3)4/h6-13,27H,1-5H3
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54n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393595
PNG
(US9969687, Compound 275)
Show SMILES Cc1cnc(cn1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C23H21ClN4O4S/c1-13-11-26-18(12-25-13)28-21(29)19-16(24)9-10-17(20(19)22(28)30)27-33(31,32)15-7-5-14(6-8-15)23(2,3)4/h5-12,27H,1-4H3
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54n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393576
PNG
(US9969687, Compound 250)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1ncccn1
Show InChI InChI=1S/C22H19ClN4O4S/c1-22(2,3)13-5-7-14(8-6-13)32(30,31)26-16-10-9-15(23)17-18(16)20(29)27(19(17)28)21-24-11-4-12-25-21/h4-12,26H,1-3H3
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56n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393570
PNG
(US9969687, Compound 242)
Show SMILES COc1cncc(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c1C
Show InChI InChI=1S/C25H24ClN3O5S/c1-14-19(12-27-13-20(14)34-5)29-23(30)21-17(26)10-11-18(22(21)24(29)31)28-35(32,33)16-8-6-15(7-9-16)25(2,3)4/h6-13,28H,1-5H3
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56n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393518
PNG
(US9969687, Compound 179)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1sccc1C#N
Show InChI InChI=1S/C23H18ClN3O4S2/c1-23(2,3)14-4-6-15(7-5-14)33(30,31)26-17-9-8-16(24)18-19(17)21(29)27(20(18)28)22-13(12-25)10-11-32-22/h4-11,26H,1-3H3
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57n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393519
PNG
(US9969687, Compound 182)
Show SMILES Cc1ccc(cn1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O4S/c1-14-5-8-16(13-26-14)28-22(29)20-18(25)11-12-19(21(20)23(28)30)27-33(31,32)17-9-6-15(7-10-17)24(2,3)4/h5-13,27H,1-4H3
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58n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393590
PNG
(US9969687, Compound 267)
Show SMILES Cc1cc(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c(C)[n+]([O-])c1
Show InChI InChI=1S/C25H24ClN3O5S/c1-14-12-20(15(2)28(32)13-14)29-23(30)21-18(26)10-11-19(22(21)24(29)31)27-35(33,34)17-8-6-16(7-9-17)25(3,4)5/h6-13,27H,1-5H3
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59n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393538
PNG
(US9969687, Compound 203)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cccnn1
Show InChI InChI=1S/C22H19ClN4O4S/c1-22(2,3)13-6-8-14(9-7-13)32(30,31)26-16-11-10-15(23)18-19(16)21(29)27(20(18)28)17-5-4-12-24-25-17/h4-12,26H,1-3H3
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59n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393544
PNG
(US9969687, Compound 212)
Show SMILES COc1cncc(CN2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c1
Show InChI InChI=1S/C25H24ClN3O5S/c1-25(2,3)16-5-7-18(8-6-16)35(32,33)28-20-10-9-19(26)21-22(20)24(31)29(23(21)30)14-15-11-17(34-4)13-27-12-15/h5-13,28H,14H2,1-4H3
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60n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393575
PNG
(US9969687, Compound 249)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1ccncn1
Show InChI InChI=1S/C22H19ClN4O4S/c1-22(2,3)13-4-6-14(7-5-13)32(30,31)26-16-9-8-15(23)18-19(16)21(29)27(20(18)28)17-10-11-24-12-25-17/h4-12,26H,1-3H3
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60n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393543
PNG
(US9969687, Compound 211)
Show SMILES COc1ccc[n+]([O-])c1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O6S/c1-24(2,3)14-7-9-15(10-8-14)35(32,33)26-17-12-11-16(25)19-20(17)23(30)28(22(19)29)21-18(34-4)6-5-13-27(21)31/h5-13,26H,1-4H3
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61n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393591
PNG
(US9969687, Compound 270)
Show SMILES Cc1nccnc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C23H21ClN4O4S/c1-13-20(26-12-11-25-13)28-21(29)18-16(24)9-10-17(19(18)22(28)30)27-33(31,32)15-7-5-14(6-8-15)23(2,3)4/h5-12,27H,1-4H3
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61n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393558
PNG
(US9969687, Compound 229)
Show SMILES Cc1ccc(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)[n+]([O-])c1
Show InChI InChI=1S/C24H22ClN3O5S/c1-14-5-12-19(27(31)13-14)28-22(29)20-17(25)10-11-18(21(20)23(28)30)26-34(32,33)16-8-6-15(7-9-16)24(2,3)4/h5-13,26H,1-4H3
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63n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393582
PNG
(US9969687, Compound 258)
Show SMILES Cc1cncc(CN2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c1
Show InChI InChI=1S/C25H24ClN3O4S/c1-15-11-16(13-27-12-15)14-29-23(30)21-19(26)9-10-20(22(21)24(29)31)28-34(32,33)18-7-5-17(6-8-18)25(2,3)4/h5-13,28H,14H2,1-4H3
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67n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393578
PNG
(US9969687, Compound 254)
Show SMILES Cc1cccc(CN2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)n1
Show InChI InChI=1S/C25H24ClN3O4S/c1-15-6-5-7-17(27-15)14-29-23(30)21-19(26)12-13-20(22(21)24(29)31)28-34(32,33)18-10-8-16(9-11-18)25(2,3)4/h5-13,28H,14H2,1-4H3
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68n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393579
PNG
(US9969687, Compound 255)
Show SMILES Cn1cnc(n1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C21H20ClN5O4S/c1-21(2,3)12-5-7-13(8-6-12)32(30,31)25-15-10-9-14(22)16-17(15)19(29)27(18(16)28)20-23-11-26(4)24-20/h5-11,25H,1-4H3
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72n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393510
PNG
(US9969687, Compound 145)
Show SMILES Cn1ccc(n1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C22H21ClN4O4S/c1-22(2,3)13-5-7-14(8-6-13)32(30,31)25-16-10-9-15(23)18-19(16)21(29)27(20(18)28)17-11-12-26(4)24-17/h5-12,25H,1-4H3
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73n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393495
PNG
(US9969687, Compound 65)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3ccc[n+]([O-])c3)C(=O)c12
Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)16-6-8-17(9-7-16)34(32,33)26-19-11-10-18(25)20-21(19)23(30)28(22(20)29)14-15-5-4-12-27(31)13-15/h4-13,26H,14H2,1-3H3
PDB

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74n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393542
PNG
(US9969687, Compound 209)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3cc[n+]([O-])cc3)C(=O)c12
Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)16-4-6-17(7-5-16)34(32,33)26-19-9-8-18(25)20-21(19)23(30)28(22(20)29)14-15-10-12-27(31)13-11-15/h4-13,26H,14H2,1-3H3
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77n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393604
PNG
(US9969687, Compound 285)
Show SMILES Cc1cc(cn(C)c1=O)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H24ClN3O5S/c1-14-12-16(13-28(5)22(14)30)29-23(31)20-18(26)10-11-19(21(20)24(29)32)27-35(33,34)17-8-6-15(7-9-17)25(2,3)4/h6-13,27H,1-5H3
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78n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393525
PNG
(US9969687, Compound 190)
Show SMILES COc1cc(cc(c1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl)C#N
Show InChI InChI=1S/C26H22ClN3O5S/c1-26(2,3)16-5-7-19(8-6-16)36(33,34)29-21-10-9-20(27)22-23(21)25(32)30(24(22)31)17-11-15(14-28)12-18(13-17)35-4/h5-13,29H,1-4H3
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81n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393599
PNG
(US9969687, Compound 280)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(C#N)c2C(=O)N(Cc3ccc[n+]([O-])c3)C(=O)c12
Show InChI InChI=1S/C25H22N4O5S/c1-25(2,3)18-7-9-19(10-8-18)35(33,34)27-20-11-6-17(13-26)21-22(20)24(31)29(23(21)30)15-16-5-4-12-28(32)14-16/h4-12,14,27H,15H2,1-3H3
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84n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393560
PNG
(US9969687, Compound 231)
Show SMILES COc1cc(CN2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c[n+]([O-])c1
Show InChI InChI=1S/C25H24ClN3O6S/c1-25(2,3)16-5-7-18(8-6-16)36(33,34)27-20-10-9-19(26)21-22(20)24(31)29(23(21)30)13-15-11-17(35-4)14-28(32)12-15/h5-12,14,27H,13H2,1-4H3
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89n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393523
PNG
(US9969687, Compound 188)
Show SMILES Cc1cc[n+]([O-])cc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O5S/c1-14-11-12-27(31)13-19(14)28-22(29)20-17(25)9-10-18(21(20)23(28)30)26-34(32,33)16-7-5-15(6-8-16)24(2,3)4/h5-13,26H,1-4H3
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89n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393503
PNG
(US9969687, Compound 120)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cccc(c1)C#N
Show InChI InChI=1S/C25H20ClN3O4S/c1-25(2,3)16-7-9-18(10-8-16)34(32,33)28-20-12-11-19(26)21-22(20)24(31)29(23(21)30)17-6-4-5-15(13-17)14-27/h4-13,28H,1-3H3
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90n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393596
PNG
(US9969687, Compound 276)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cc(F)ccn1
Show InChI InChI=1S/C23H19ClFN3O4S/c1-23(2,3)13-4-6-15(7-5-13)33(31,32)27-17-9-8-16(24)19-20(17)22(30)28(21(19)29)18-12-14(25)10-11-26-18/h4-12,27H,1-3H3
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91n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393535
PNG
(US9969687, Compound 200)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cc(ccn1)C#N
Show InChI InChI=1S/C24H19ClN4O4S/c1-24(2,3)15-4-6-16(7-5-15)34(32,33)28-18-9-8-17(25)20-21(18)23(31)29(22(20)30)19-12-14(13-26)10-11-27-19/h4-12,28H,1-3H3
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92n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393564
PNG
(US9969687, Compound 235)
Show SMILES COc1ccc(CN2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)cn1
Show InChI InChI=1S/C25H24ClN3O5S/c1-25(2,3)16-6-8-17(9-7-16)35(32,33)28-19-11-10-18(26)21-22(19)24(31)29(23(21)30)14-15-5-12-20(34-4)27-13-15/h5-13,28H,14H2,1-4H3
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94n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393511
PNG
(US9969687, Compound 148)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cn[nH]c1
Show InChI InChI=1S/C21H19ClN4O4S/c1-21(2,3)12-4-6-14(7-5-12)31(29,30)25-16-9-8-15(22)17-18(16)20(28)26(19(17)27)13-10-23-24-11-13/h4-11,25H,1-3H3,(H,23,24)
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94n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393498
PNG
(US9969687, Compound 82)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(C#N)c2C(=O)N(Cc3cccnc3)C(=O)c12
Show InChI InChI=1S/C25H22N4O4S/c1-25(2,3)18-7-9-19(10-8-18)34(32,33)28-20-11-6-17(13-26)21-22(20)24(31)29(23(21)30)15-16-5-4-12-27-14-16/h4-12,14,28H,15H2,1-3H3
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98n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393532
PNG
(US9969687, Compound 196)
Show SMILES CC(Cc1cccnc1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C26H26ClN3O4S/c1-16(14-17-6-5-13-28-15-17)30-24(31)22-20(27)11-12-21(23(22)25(30)32)29-35(33,34)19-9-7-18(8-10-19)26(2,3)4/h5-13,15-16,29H,14H2,1-4H3
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103n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393608
PNG
(US9969687, Compound 289)
Show SMILES C[N]1=CC(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)=C(N1)C(O)=O
Show InChI InChI=1S/C23H22ClN4O6S/c1-23(2,3)12-5-7-13(8-6-12)35(33,34)26-15-10-9-14(24)17-18(15)21(30)28(20(17)29)16-11-27(4)25-19(16)22(31)32/h5-11,25-26H,1-4H3,(H,31,32)
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109n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393571
PNG
(US9969687, Compound 243)
Show SMILES COc1ccc(N2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c(C)[n+]1[O-]
Show InChI InChI=1S/C25H24ClN3O6S/c1-14-19(12-13-20(35-5)29(14)32)28-23(30)21-17(26)10-11-18(22(21)24(28)31)27-36(33,34)16-8-6-15(7-9-16)25(2,3)4/h6-13,27H,1-5H3
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115n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393586
PNG
(US9969687, Compound 262)
Show SMILES Cc1cc(CN2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)c[n+]([O-])c1
Show InChI InChI=1S/C25H24ClN3O5S/c1-15-11-16(13-28(32)12-15)14-29-23(30)21-19(26)9-10-20(22(21)24(29)31)27-35(33,34)18-7-5-17(6-8-18)25(2,3)4/h5-13,27H,14H2,1-4H3
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119n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393514
PNG
(US9969687, Compound 155)
Show SMILES COC(=O)c1sccc1N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H21ClN2O6S2/c1-24(2,3)13-5-7-14(8-6-13)35(31,32)26-16-10-9-15(25)18-19(16)22(29)27(21(18)28)17-11-12-34-20(17)23(30)33-4/h5-12,26H,1-4H3
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135n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393508
PNG
(US9969687, Compound 138)
Show SMILES COc1cccc(c1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H23ClN2O5S/c1-25(2,3)15-8-10-18(11-9-15)34(31,32)27-20-13-12-19(26)21-22(20)24(30)28(23(21)29)16-6-5-7-17(14-16)33-4/h5-14,27H,1-4H3
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138n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393577
PNG
(US9969687, Compound 251)
Show SMILES Cc1ccc(CN2C(=O)c3c(C2=O)c(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)ccc3Cl)nc1
Show InChI InChI=1S/C25H24ClN3O4S/c1-15-5-8-17(27-13-15)14-29-23(30)21-19(26)11-12-20(22(21)24(29)31)28-34(32,33)18-9-6-16(7-10-18)25(2,3)4/h5-13,28H,14H2,1-4H3
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148n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393507
PNG
(US9969687, Compound 133)
Show SMILES Fc1ccc(cc1C(F)(F)F)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3cccc(c3)C#N)C(=O)c12
Show InChI InChI=1S/C23H12ClF4N3O4S/c24-16-5-7-18(30-36(34,35)14-4-6-17(25)15(9-14)23(26,27)28)20-19(16)21(32)31(22(20)33)11-13-3-1-2-12(8-13)10-29/h1-9,30H,11H2
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158n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393499
PNG
(US9969687, Compound 90)
Show SMILES COc1cncc(c1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O5S/c1-24(2,3)14-5-7-17(8-6-14)34(31,32)27-19-10-9-18(25)20-21(19)23(30)28(22(20)29)15-11-16(33-4)13-26-12-15/h5-13,27H,1-4H3
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174n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393491
PNG
(US9969687, Compound 44)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1ccc[n+]([O-])c1
Show InChI InChI=1S/C23H20ClN3O5S/c1-23(2,3)14-6-8-16(9-7-14)33(31,32)25-18-11-10-17(24)19-20(18)22(29)27(21(19)28)15-5-4-12-26(30)13-15/h4-13,25H,1-3H3
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179n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393501
PNG
(US9969687, Compound 104)
Show SMILES Cc1cncc(c1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C24H22ClN3O4S/c1-14-11-16(13-26-12-14)28-22(29)20-18(25)9-10-19(21(20)23(28)30)27-33(31,32)17-7-5-15(6-8-17)24(2,3)4/h5-13,27H,1-4H3
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239n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393500
PNG
(US9969687, Compound 103)
Show SMILES CCOc1cncc(c1)N1C(=O)c2c(C1=O)c(NS(=O)(=O)c1ccc(cc1)C(C)(C)C)ccc2Cl
Show InChI InChI=1S/C25H24ClN3O5S/c1-5-34-17-12-16(13-27-14-17)29-23(30)21-19(26)10-11-20(22(21)24(29)31)28-35(32,33)18-8-6-15(7-9-18)25(2,3)4/h6-14,28H,5H2,1-4H3
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242n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393496
PNG
(US9969687, Compound 66)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3cccnc3)C(=O)c12
Show InChI InChI=1S/C21H13ClF3N3O4S/c22-15-7-8-16(27-33(31,32)14-5-3-13(4-6-14)21(23,24)25)18-17(15)19(29)28(20(18)30)11-12-2-1-9-26-10-12/h1-10,27H,11H2
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269n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393493
PNG
(US9969687, Compound 47)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cccnc1
Show InChI InChI=1S/C20H11ClF3N3O4S/c21-14-7-8-15(26-32(30,31)13-5-3-11(4-6-13)20(22,23)24)17-16(14)18(28)27(19(17)29)12-2-1-9-25-10-12/h1-10,26H
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309n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393492
PNG
(US9969687, Compound 45)
Show SMILES FC(F)(F)Oc1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cccnc1
Show InChI InChI=1S/C20H11ClF3N3O5S/c21-14-7-8-15(17-16(14)18(28)27(19(17)29)11-2-1-9-25-10-11)26-33(30,31)13-5-3-12(4-6-13)32-20(22,23)24/h1-10,26H
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314n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393504
PNG
(US9969687, Compound 121)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cccc(c1)C#N
Show InChI InChI=1S/C22H11ClF3N3O4S/c23-16-8-9-17(28-34(32,33)15-6-4-13(5-7-15)22(24,25)26)19-18(16)20(30)29(21(19)31)14-3-1-2-12(10-14)11-27/h1-10,28H
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337n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393505
PNG
(US9969687, Compound 126)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3cccc(c3)C#N)C(=O)c12
Show InChI InChI=1S/C26H22ClN3O4S/c1-26(2,3)18-7-9-19(10-8-18)35(33,34)29-21-12-11-20(27)22-23(21)25(32)30(24(22)31)15-17-6-4-5-16(13-17)14-28/h4-13,29H,15H2,1-3H3
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343n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393512
PNG
(US9969687, Compound 149)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(C(=O)c12)c1cn[nH]c1
Show InChI InChI=1S/C18H10ClF3N4O4S/c19-12-5-6-13(15-14(12)16(27)26(17(15)28)10-7-23-24-8-10)25-31(29,30)11-3-1-9(2-4-11)18(20,21)22/h1-8,25H,(H,23,24)
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397n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393506
PNG
(US9969687, Compound 128)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc1ccc(Cl)c2C(=O)N(Cc3cccc(c3)C#N)C(=O)c12
Show InChI InChI=1S/C23H13ClF3N3O4S/c24-17-8-9-18(29-35(33,34)16-6-4-15(5-7-16)23(25,26)27)20-19(17)21(31)30(22(20)32)12-14-3-1-2-13(10-14)11-28/h1-10,29H,12H2
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447n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393515
PNG
(US9969687, Compound 160)
Show SMILES Cc1ccc(NS(=O)(=O)c2ccc(cc2)C(C)(C)C)c2C(=O)N(Cc3cccnc3)C(=O)c12
Show InChI InChI=1S/C25H25N3O4S/c1-16-7-12-20(27-33(31,32)19-10-8-18(9-11-19)25(2,3)4)22-21(16)23(29)28(24(22)30)15-17-6-5-13-26-14-17/h5-14,27H,15H2,1-4H3
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776n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393488
PNG
(US9969687, Compound 1)
Show SMILES CC(C)(C)c1ccc(cc1)S(=O)(=O)Nc1cccc2C(=O)N(C(=O)c12)c1cccnc1
Show InChI InChI=1S/C23H21N3O4S/c1-23(2,3)15-9-11-17(12-10-15)31(29,30)25-19-8-4-7-18-20(19)22(28)26(21(18)27)16-6-5-13-24-14-16/h4-14,25H,1-3H3
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1.24E+3n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
C-C chemokine receptor type 9


(Homo sapiens (Human))
BDBM393489
PNG
(US9969687, Compound 6)
Show SMILES FC(F)(F)c1ccc(cc1)S(=O)(=O)Nc1cccc2C(=O)N(C(=O)c12)c1cccnc1
Show InChI InChI=1S/C20H12F3N3O4S/c21-20(22,23)12-6-8-14(9-7-12)31(29,30)25-16-5-1-4-15-17(16)19(28)26(18(15)27)13-3-2-10-24-11-13/h1-11,25H
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5.63E+3n/an/an/an/an/an/an/an/a



Norgine B.V.

US Patent


Assay Description
A calcium flux assay was used to determine the ability of the compounds to interfere with the binding between CCR9 and its chemokine ligand (TECK) in...


US Patent US9969687 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%