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Patent code US9969726

Compile Data Set for Download or QSAR

Found 724 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393730
PNG
(US9969726, Example 20)
Show SMILES O\N=C/c1cc(ccc1F)-c1cccc(c1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C22H15FN2OS/c23-20-10-9-17(12-19(20)13-24-26)16-7-4-8-18(11-16)21-14-27-22(25-21)15-5-2-1-3-6-15/h1-14,26H/b24-13-
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US Patent
n/an/an/an/a>3.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393732
PNG
(US9969726, Example 22 | US9969726, Example 28)
Show SMILES c1sc(nc1-c1cccc(c1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H15NS/c1-3-8-16(9-4-1)18-12-7-13-19(14-18)20-15-23-21(22-20)17-10-5-2-6-11-17/h1-15H
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n/an/an/an/a>3.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393732
PNG
(US9969726, Example 22 | US9969726, Example 28)
Show SMILES c1sc(nc1-c1cccc(c1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H15NS/c1-3-8-16(9-4-1)18-12-7-13-19(14-18)20-15-23-21(22-20)17-10-5-2-6-11-17/h1-15H
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393733
PNG
(US9969726, Example 23)
Show SMILES COc1ccccc1-c1cccc(c1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C22H17NOS/c1-24-21-13-6-5-12-19(21)17-10-7-11-18(14-17)20-15-25-22(23-20)16-8-3-2-4-9-16/h2-15H,1H3
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393736
PNG
(US9969726, Example 26)
Show SMILES Clc1ccccc1-c1cccc(c1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C21H14ClNS/c22-19-12-5-4-11-18(19)16-9-6-10-17(13-16)20-14-24-21(23-20)15-7-2-1-3-8-15/h1-14H
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n/an/an/an/a>3.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393737
PNG
(US9969726, Example 27)
Show SMILES Fc1ccc(cc1)-c1csc(n1)-c1ccccc1
Show InChI InChI=1S/C15H10FNS/c16-13-8-6-11(7-9-13)14-10-18-15(17-14)12-4-2-1-3-5-12/h1-10H
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n/an/an/an/a>3.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393732
PNG
(US9969726, Example 22 | US9969726, Example 28)
Show SMILES c1sc(nc1-c1cccc(c1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H15NS/c1-3-8-16(9-4-1)18-12-7-13-19(14-18)20-15-23-21(22-20)17-10-5-2-6-11-17/h1-15H
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393739
PNG
(US9969726, Example 29)
Show SMILES COc1ccc(cc1OC)-c1nc(cs1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C23H19NO2S/c1-25-21-12-11-19(14-22(21)26-2)23-24-20(15-27-23)18-10-6-9-17(13-18)16-7-4-3-5-8-16/h3-15H,1-2H3
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n/an/an/an/a 1.10E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393739
PNG
(US9969726, Example 29)
Show SMILES COc1ccc(cc1OC)-c1nc(cs1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C23H19NO2S/c1-25-21-12-11-19(14-22(21)26-2)23-24-20(15-27-23)18-10-6-9-17(13-18)16-7-4-3-5-8-16/h3-15H,1-2H3
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n/an/an/an/a 4.02E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393740
PNG
(US9969726, Example 30)
Show SMILES c1sc(nc1-c1cccc(c1)-c1ccccc1)-c1cccc2ccccc12
Show InChI InChI=1S/C25H17NS/c1-2-8-18(9-3-1)20-12-6-13-21(16-20)24-17-27-25(26-24)23-15-7-11-19-10-4-5-14-22(19)23/h1-17H
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n/an/an/an/a>3.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393742
PNG
(US9969726, Example 32)
Show SMILES c1sc(nc1-c1cccc(c1)-c1ccccc1)-c1ccc2ccccc2c1
Show InChI InChI=1S/C25H17NS/c1-2-7-18(8-3-1)21-11-6-12-22(15-21)24-17-27-25(26-24)23-14-13-19-9-4-5-10-20(19)16-23/h1-17H
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393743
PNG
(US9969726, Example 33)
Show SMILES OC(=O)c1cccc(c1)-c1nc(cs1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C22H15NO2S/c24-22(25)19-11-5-10-18(13-19)21-23-20(14-26-21)17-9-4-8-16(12-17)15-6-2-1-3-7-15/h1-14H,(H,24,25)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393746
PNG
(US9969726, Example 36)
Show SMILES C(=C/c1ccccc1)\c1nc(cs1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C23H17NS/c1-3-8-18(9-4-1)14-15-23-24-22(17-25-23)21-13-7-12-20(16-21)19-10-5-2-6-11-19/h1-17H/b15-14+
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n/an/an/an/a 3.47E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393748
PNG
(US9969726, Example 38)
Show SMILES Fc1ccc(cc1)-c1cccc(c1)-c1nsc(n1)-c1ccccc1
Show InChI InChI=1S/C20H13FN2S/c21-18-11-9-14(10-12-18)16-7-4-8-17(13-16)19-22-20(24-23-19)15-5-2-1-3-6-15/h1-13H
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n/an/an/an/a 100n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393752
PNG
(US9969726, Example 42)
Show SMILES Fc1ccc(cc1)-c1cccc(c1)-c1nsc(n1)-c1ccoc1
Show InChI InChI=1S/C18H11FN2OS/c19-16-6-4-12(5-7-16)13-2-1-3-14(10-13)17-20-18(23-21-17)15-8-9-22-11-15/h1-11H
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n/an/an/an/a 3.63E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393753
PNG
(US9969726, Example 43)
Show SMILES Fc1cccc(c1)-c1cccc(c1)-c1nsc(n1)-c1ccoc1
Show InChI InChI=1S/C18H11FN2OS/c19-16-6-2-4-13(10-16)12-3-1-5-14(9-12)17-20-18(23-21-17)15-7-8-22-11-15/h1-11H
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n/an/an/an/a 1.23E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393757
PNG
(US9969726, Example 47)
Show SMILES c1oc(nc1-c1cccc(c1)-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C21H15NO/c1-3-8-16(9-4-1)18-12-7-13-19(14-18)20-15-23-21(22-20)17-10-5-2-6-11-17/h1-15H
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393758
PNG
(US9969726, Example 48)
Show SMILES c1ccc(cc1)-c1nc(no1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C20H14N2O/c1-3-8-15(9-4-1)17-12-7-13-18(14-17)19-21-20(23-22-19)16-10-5-2-6-11-16/h1-14H
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393760
PNG
(US9969726, Example 49A | US9969726, Example 60)
Show SMILES c1ccc(cc1)-c1nc(nn1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H19N3/c1-4-11-20(12-5-1)22-15-10-16-23(19-22)25-27-26(21-13-6-2-7-14-21)29(28-25)24-17-8-3-9-18-24/h1-19H
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n/an/an/an/a 1.36E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393761
PNG
(US9969726, Example 50)
Show SMILES Cn1nc(nc1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C21H17N3/c1-24-21(17-11-6-3-7-12-17)22-20(23-24)19-14-8-13-18(15-19)16-9-4-2-5-10-16/h2-15H,1H3
PDB

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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393762
PNG
(US9969726, Example 51)
Show SMILES Fc1ccc(cc1)-c1cccc(c1)-c1nc(-c2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C26H18FN3/c27-23-16-14-19(15-17-23)21-10-7-11-22(18-21)25-28-26(20-8-3-1-4-9-20)30(29-25)24-12-5-2-6-13-24/h1-18H
PDB

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n/an/an/an/a 5.80E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393763
PNG
(US9969726, Example 52)
Show SMILES Fc1cccc(c1)-c1cccc(c1)-c1nc(-c2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C26H18FN3/c27-23-14-8-12-21(18-23)20-11-7-13-22(17-20)25-28-26(19-9-3-1-4-10-19)30(29-25)24-15-5-2-6-16-24/h1-18H
PDB

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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393763
PNG
(US9969726, Example 52)
Show SMILES Fc1cccc(c1)-c1cccc(c1)-c1nc(-c2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C26H18FN3/c27-23-14-8-12-21(18-23)20-11-7-13-22(17-20)25-28-26(19-9-3-1-4-10-19)30(29-25)24-15-5-2-6-16-24/h1-18H
PDB

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n/an/an/an/a 1.51E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393764
PNG
(US9969726, Example 53)
Show SMILES c1csc(c1)-c1nc(nn1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C24H17N3S/c1-3-9-18(10-4-1)19-11-7-12-20(17-19)23-25-24(22-15-8-16-28-22)27(26-23)21-13-5-2-6-14-21/h1-17H
PDB

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n/an/an/an/a 1.68E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393767
PNG
(US9969726, Example 56)
Show SMILES Fc1cccc(c1)-n1nc(nc1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H18FN3/c27-23-15-8-16-24(18-23)30-26(20-11-5-2-6-12-20)28-25(29-30)22-14-7-13-21(17-22)19-9-3-1-4-10-19/h1-18H
PDB

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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393760
PNG
(US9969726, Example 49A | US9969726, Example 60)
Show SMILES c1ccc(cc1)-c1nc(nn1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H19N3/c1-4-11-20(12-5-1)22-15-10-16-23(19-22)25-27-26(21-13-6-2-7-14-21)29(28-25)24-17-8-3-9-18-24/h1-19H
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393760
PNG
(US9969726, Example 49A | US9969726, Example 60)
Show SMILES c1ccc(cc1)-c1nc(nn1-c1ccccc1)-c1cccc(c1)-c1ccccc1
Show InChI InChI=1S/C26H19N3/c1-4-11-20(12-5-1)22-15-10-16-23(19-22)25-27-26(21-13-6-2-7-14-21)29(28-25)24-17-8-3-9-18-24/h1-19H
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n/an/an/an/a 5.30E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393772
PNG
(US9969726, Example 61)
Show SMILES OC(=O)c1ccccc1-c1cccc(c1)-c1nc(-c2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C27H19N3O2/c31-27(32)24-17-8-7-16-23(24)20-12-9-13-21(18-20)25-28-26(19-10-3-1-4-11-19)30(29-25)22-14-5-2-6-15-22/h1-18H,(H,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393773
PNG
(US9969726, Example 62)
Show SMILES c1coc(c1)-c1cccc(c1)-c1nc(-c2ccccc2)n(n1)-c1ccccc1
Show InChI InChI=1S/C24H17N3O/c1-3-9-18(10-4-1)24-25-23(26-27(24)21-13-5-2-6-14-21)20-12-7-11-19(17-20)22-15-8-16-28-22/h1-17H
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n/an/an/an/a>3.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393777
PNG
(US9969726, Example 66)
Show SMILES OC(=O)c1cccc(c1)-c1cccc(c1)-c1nc(nn1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C27H19N3O2/c31-27(32)23-14-8-12-21(18-23)20-11-7-13-22(17-20)26-28-25(19-9-3-1-4-10-19)29-30(26)24-15-5-2-6-16-24/h1-18H,(H,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393777
PNG
(US9969726, Example 66)
Show SMILES OC(=O)c1cccc(c1)-c1cccc(c1)-c1nc(nn1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C27H19N3O2/c31-27(32)23-14-8-12-21(18-23)20-11-7-13-22(17-20)26-28-25(19-9-3-1-4-10-19)29-30(26)24-15-5-2-6-16-24/h1-18H,(H,31,32)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393780
PNG
(US9969726, Example 69)
Show SMILES OC(=O)c1cccc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H13F6N3O2/c25-23(26,27)19-8-7-17(12-31-19)18-11-20(24(28,29)30)33-21(32-18)15-5-1-3-13(9-15)14-4-2-6-16(10-14)22(34)35/h1-12H,(H,34,35)
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n/an/an/an/a 340n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393783
PNG
(US9969726, Example 72)
Show SMILES OC(=O)c1ccccc1-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H13F6N3O2/c25-23(26,27)19-9-8-15(12-31-19)18-11-20(24(28,29)30)33-21(32-18)14-5-3-4-13(10-14)16-6-1-2-7-17(16)22(34)35/h1-12H,(H,34,35)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393784
PNG
(US9969726, Example 73)
Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H12F7N3O2/c25-17-6-4-13(9-16(17)22(35)36)12-2-1-3-14(8-12)21-33-18(10-20(34-21)24(29,30)31)15-5-7-19(32-11-15)23(26,27)28/h1-11H,(H,35,36)
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n/an/an/an/a 170n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393785
PNG
(US9969726, Example 74)
Show SMILES OC(=O)c1ccc(cc1Cl)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H12ClF6N3O2/c25-17-9-13(4-6-16(17)22(35)36)12-2-1-3-14(8-12)21-33-18(10-20(34-21)24(29,30)31)15-5-7-19(32-11-15)23(26,27)28/h1-11H,(H,35,36)
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n/an/an/an/a 6.76E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393785
PNG
(US9969726, Example 74)
Show SMILES OC(=O)c1ccc(cc1Cl)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H12ClF6N3O2/c25-17-9-13(4-6-16(17)22(35)36)12-2-1-3-14(8-12)21-33-18(10-20(34-21)24(29,30)31)15-5-7-19(32-11-15)23(26,27)28/h1-11H,(H,35,36)
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n/an/an/an/a 6.52E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393785
PNG
(US9969726, Example 74)
Show SMILES OC(=O)c1ccc(cc1Cl)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H12ClF6N3O2/c25-17-9-13(4-6-16(17)22(35)36)12-2-1-3-14(8-12)21-33-18(10-20(34-21)24(29,30)31)15-5-7-19(32-11-15)23(26,27)28/h1-11H,(H,35,36)
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n/an/an/an/a>1.00E+4n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393787
PNG
(US9969726, Example 76)
Show SMILES OC(=O)c1cc(F)cc(c1)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H12F7N3O2/c25-17-8-15(7-16(9-17)22(35)36)12-2-1-3-13(6-12)21-33-18(10-20(34-21)24(29,30)31)14-4-5-19(32-11-14)23(26,27)28/h1-11H,(H,35,36)
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n/an/an/an/a 1.61E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393788
PNG
(US9969726, Example 77)
Show SMILES COc1ccc(cc1-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F)C(O)=O
Show InChI InChI=1S/C25H15F6N3O3/c1-37-19-7-5-15(23(35)36)10-17(19)13-3-2-4-14(9-13)22-33-18(11-21(34-22)25(29,30)31)16-6-8-20(32-12-16)24(26,27)28/h2-12H,1H3,(H,35,36)
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n/an/an/an/a 1.70E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393792
PNG
(US9969726, Example 81)
Show SMILES OC(=O)c1ccc(cc1)-c1ccc(cc1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H13F6N3O2/c25-23(26,27)19-10-9-17(12-31-19)18-11-20(24(28,29)30)33-21(32-18)15-5-1-13(2-6-15)14-3-7-16(8-4-14)22(34)35/h1-12H,(H,34,35)
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n/an/an/an/a 440n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393793
PNG
(US9969726, Example 82)
Show SMILES OC(=O)c1cc(ccc1F)-c1ccc(cc1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H12F7N3O2/c25-17-7-5-14(9-16(17)22(35)36)12-1-3-13(4-2-12)21-33-18(10-20(34-21)24(29,30)31)15-6-8-19(32-11-15)23(26,27)28/h1-11H,(H,35,36)
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n/an/an/an/a 490n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393795
PNG
(US9969726, Example 84)
Show SMILES OC(=O)c1cc(F)cc(c1)-c1ccc(cc1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(nc1)C(F)(F)F
Show InChI InChI=1S/C24H12F7N3O2/c25-17-8-15(7-16(9-17)22(35)36)12-1-3-13(4-2-12)21-33-18(10-20(34-21)24(29,30)31)14-5-6-19(32-11-14)23(26,27)28/h1-11H,(H,35,36)
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n/an/an/an/a 2.79E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393798
PNG
(US9969726, Example 87)
Show SMILES COc1ccc(cc1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C25H16F4N2O3/c1-34-18-8-5-14(6-9-18)21-13-22(25(27,28)29)31-23(30-21)17-4-2-3-15(11-17)16-7-10-20(26)19(12-16)24(32)33/h2-13H,1H3,(H,32,33)
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n/an/an/an/a 1.07E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393798
PNG
(US9969726, Example 87)
Show SMILES COc1ccc(cc1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C25H16F4N2O3/c1-34-18-8-5-14(6-9-18)21-13-22(25(27,28)29)31-23(30-21)17-4-2-3-15(11-17)16-7-10-20(26)19(12-16)24(32)33/h2-13H,1H3,(H,32,33)
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n/an/an/an/a 1.00E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393800
PNG
(US9969726, Example 88)
Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccco1
Show InChI InChI=1S/C22H12F4N2O3/c23-16-7-6-13(10-15(16)21(29)30)12-3-1-4-14(9-12)20-27-17(18-5-2-8-31-18)11-19(28-20)22(24,25)26/h1-11H,(H,29,30)
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n/an/an/an/a 340n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393804
PNG
(US9969726, Example 92)
Show SMILES Cc1cccc(c1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C25H16F4N2O2/c1-14-4-2-6-17(10-14)21-13-22(25(27,28)29)31-23(30-21)18-7-3-5-15(11-18)16-8-9-20(26)19(12-16)24(32)33/h2-13H,1H3,(H,32,33)
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n/an/an/an/a 2.79E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393805
PNG
(US9969726, Example 93)
Show SMILES Cc1cc(C)cc(c1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C26H18F4N2O2/c1-14-8-15(2)10-19(9-14)22-13-23(26(28,29)30)32-24(31-22)18-5-3-4-16(11-18)17-6-7-21(27)20(12-17)25(33)34/h3-13H,1-2H3,(H,33,34)
PDB

UniProtKB/SwissProt

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PC sid
UniChem
US Patent
n/an/an/an/a 2.31E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus (Rat))
BDBM393808
PNG
(US9969726, Example 96)
Show SMILES CC(C)(C)c1ccc(cc1)-c1cc(nc(n1)-c1cccc(c1)-c1ccc(F)c(c1)C(O)=O)C(F)(F)F
Show InChI InChI=1S/C28H22F4N2O2/c1-27(2,3)20-10-7-16(8-11-20)23-15-24(28(30,31)32)34-25(33-23)19-6-4-5-17(13-19)18-9-12-22(29)21(14-18)26(35)36/h4-15H,1-3H3,(H,35,36)
PDB

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US Patent
n/an/an/an/a 1.52E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393810
PNG
(US9969726, Example 98)
Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccc(Cl)cc1
Show InChI InChI=1S/C24H13ClF4N2O2/c25-17-7-4-13(5-8-17)20-12-21(24(27,28)29)31-22(30-20)16-3-1-2-14(10-16)15-6-9-19(26)18(11-15)23(32)33/h1-12H,(H,32,33)
PDB

UniProtKB/SwissProt

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US Patent
n/an/an/an/a 350n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
Metabotropic glutamate receptor


(Rattus norvegicus)
BDBM393812
PNG
(US9969726, Example 100)
Show SMILES OC(=O)c1cc(ccc1F)-c1cccc(c1)-c1nc(cc(n1)C(F)(F)F)-c1ccccc1F
Show InChI InChI=1S/C24H13F5N2O2/c25-18-7-2-1-6-16(18)20-12-21(24(27,28)29)31-22(30-20)15-5-3-4-13(10-15)14-8-9-19(26)17(11-14)23(32)33/h1-12H,(H,32,33)
PDB

UniProtKB/SwissProt

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.21E+3n/an/an/an/a



SANFORD-BURNHAM MEDICAL RESEARCH INSTITUTE

US Patent


Assay Description
Human Embryonic Kidney (HEK-293) cell lines co-expressing rat mGlu receptors 2, 3, 4, 6, 7 or 8 and G protein-coupled inwardly-rectifying potassium (...


US Patent US9969726 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%