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Patent code US9969743

Compile Data Set for Download or QSAR

Found 260 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301790
PNG
( N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)N3CCN(CC3)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C25H33Cl2N5O/c26-22-9-6-10-23(24(22)27)31-15-13-29(14-16-31)12-5-4-11-28-25(33)32-19-17-30(18-20-32)21-7-2-1-3-8-21/h1-3,6-10H,4-5,11-20H2,(H,28,33)
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0.390n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301861
PNG
(N-(4-(4-(2,3-Dichlorophenyl)piperazin-1-yl)butyl)-...)
Show SMILES Clc1cccc(N2CCN(CCCCNC(=O)N3CCC(CC3)c3ccccc3)CC2)c1Cl
Show InChI InChI=1S/C26H34Cl2N4O/c27-23-9-6-10-24(25(23)28)31-19-17-30(18-20-31)14-5-4-13-29-26(33)32-15-11-22(12-16-32)21-7-2-1-3-8-21/h1-3,6-10,22H,4-5,11-20H2,(H,29,33)
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1.90n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301779
PNG
(4-Phenyl-N-(4-(4-phenylpiperazin-1-yl)butyl)pipera...)
Show SMILES O=C(NCCCCN1CCN(CC1)c1ccccc1)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C25H35N5O/c31-25(30-21-19-29(20-22-30)24-11-5-2-6-12-24)26-13-7-8-14-27-15-17-28(18-16-27)23-9-3-1-4-10-23/h1-6,9-12H,7-8,13-22H2,(H,26,31)
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2n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301856
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCc3ccccc3CC2)CC1
Show InChI InChI=1S/C28H39F3N6O/c1-27(2,3)25-33-23(28(29,30)31)20-24(34-25)36-18-16-35(17-19-36)13-7-6-12-32-26(38)37-14-10-21-8-4-5-9-22(21)11-15-37/h4-5,8-9,20H,6-7,10-19H2,1-3H3,(H,32,38)
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2.30n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301854
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES COc1ccc2CN(Cc2c1)C(=O)NCCCCN1CCN(CC1)c1cc(nc(n1)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C27H37F3N6O2/c1-26(2,3)24-32-22(27(28,29)30)16-23(33-24)35-13-11-34(12-14-35)10-6-5-9-31-25(37)36-17-19-7-8-21(38-4)15-20(19)18-36/h7-8,15-16H,5-6,9-14,17-18H2,1-4H3,(H,31,37)
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2.30n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301845
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccncc2)CC1
Show InChI InChI=1S/C27H39F3N8O/c1-26(2,3)24-33-22(27(28,29)30)20-23(34-24)37-14-12-35(13-15-37)11-5-4-8-32-25(39)38-18-16-36(17-19-38)21-6-9-31-10-7-21/h6-7,9-10,20H,4-5,8,11-19H2,1-3H3,(H,32,39)
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2.60n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301793
PNG
(N-(4-(4-(2-(tert-Butyl)-6-methylpyrimidin-4-yl)pip...)
Show SMILES Cc1cc(nc(n1)C(C)(C)C)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccccc2)CC1
Show InChI InChI=1S/C28H43N7O/c1-23-22-25(31-26(30-23)28(2,3)4)34-16-14-32(15-17-34)13-9-8-12-29-27(36)35-20-18-33(19-21-35)24-10-6-5-7-11-24/h5-7,10-11,22H,8-9,12-21H2,1-4H3,(H,29,36)
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2.70n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301814
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccccc2)CC1
Show InChI InChI=1S/C28H40F3N7O/c1-27(2,3)25-33-23(28(29,30)31)21-24(34-25)37-15-13-35(14-16-37)12-8-7-11-32-26(39)38-19-17-36(18-20-38)22-9-5-4-6-10-22/h4-6,9-10,21H,7-8,11-20H2,1-3H3,(H,32,39)
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2.70n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM393961
PNG
(US9969743, 55)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCc3c(C2)[nH]c2ccccc32)CC1
Show InChI InChI=1S/C29H38F3N7O/c1-28(2,3)26-35-24(29(30,31)32)18-25(36-26)38-16-14-37(15-17-38)12-7-6-11-33-27(40)39-13-10-21-20-8-4-5-9-22(20)34-23(21)19-39/h4-5,8-9,18,34H,6-7,10-17,19H2,1-3H3,(H,33,40)
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3n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301852
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CC(C2)c2ccncc2)CC1
Show InChI InChI=1S/C26H36F3N7O/c1-25(2,3)23-32-21(26(27,28)29)16-22(33-23)35-14-12-34(13-15-35)11-5-4-8-31-24(37)36-17-20(18-36)19-6-9-30-10-7-19/h6-7,9-10,16,20H,4-5,8,11-15,17-18H2,1-3H3,(H,31,37)
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3.5n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301792
PNG
(N-(4-(4-(3-Cyano-5-(trifluoromethyl)phenyl)piperaz...)
Show SMILES FC(F)(F)c1cc(cc(c1)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccccc2)CC1)C#N
Show InChI InChI=1S/C27H33F3N6O/c28-27(29,30)23-18-22(21-31)19-25(20-23)35-12-10-33(11-13-35)9-5-4-8-32-26(37)36-16-14-34(15-17-36)24-6-2-1-3-7-24/h1-3,6-7,18-20H,4-5,8-17H2,(H,32,37)
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4.10n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50057762
PNG
(CHEMBL3323011 | US9598387, Compound 113 | US996974...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)c2cn3ccccc3n2)CC1
Show InChI InChI=1S/C25H32F3N7O/c1-24(2,3)23-31-19(25(26,27)28)16-21(32-23)34-14-12-33(13-15-34)10-7-5-9-29-22(36)18-17-35-11-6-4-8-20(35)30-18/h4,6,8,11,16-17H,5,7,9-10,12-15H2,1-3H3,(H,29,36)
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4.20n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301844
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2cccnc2)CC1
Show InChI InChI=1S/C27H39F3N8O/c1-26(2,3)24-33-22(27(28,29)30)19-23(34-24)37-13-11-35(12-14-37)10-5-4-9-32-25(39)38-17-15-36(16-18-38)21-7-6-8-31-20-21/h6-8,19-20H,4-5,9-18H2,1-3H3,(H,32,39)
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5.90n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301866
PNG
(N-(4-(4-(2-(tert-Butyl)-6-methylpyrimidin-4-yl)pip...)
Show SMILES Cc1cc(nc(n1)C(C)(C)C)N1CCN(CCCCNC(=O)N2CCC(CC2)n2c3ccccc3[nH]c2=O)CC1
Show InChI InChI=1S/C30H44N8O2/c1-22-21-26(34-27(32-22)30(2,3)4)36-19-17-35(18-20-36)14-8-7-13-31-28(39)37-15-11-23(12-16-37)38-25-10-6-5-9-24(25)33-29(38)40/h5-6,9-10,21,23H,7-8,11-20H2,1-4H3,(H,31,39)(H,33,40)
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7.30n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301843
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccccn2)CC1
Show InChI InChI=1S/C27H39F3N8O/c1-26(2,3)24-33-21(27(28,29)30)20-23(34-24)37-14-12-35(13-15-37)11-7-6-10-32-25(39)38-18-16-36(17-19-38)22-8-4-5-9-31-22/h4-5,8-9,20H,6-7,10-19H2,1-3H3,(H,32,39)
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8n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50057763
PNG
(CHEMBL3323016 | US9598387, Compound 115 | US996974...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)c2cn3ccncc3n2)CC1
Show InChI InChI=1S/C24H31F3N8O/c1-23(2,3)22-31-18(24(25,26)27)14-19(32-22)34-12-10-33(11-13-34)8-5-4-6-29-21(36)17-16-35-9-7-28-15-20(35)30-17/h7,9,14-16H,4-6,8,10-13H2,1-3H3,(H,29,36)
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8n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50057777
PNG
(CHEMBL3323010 | US9598387, Compound 112 | US996974...)
Show SMILES CC(C)(C)c1nc(cc(n1)N1CCN(CCCCNC(=O)c2cn3ccccc3n2)CC1)C1CC1
Show InChI InChI=1S/C27H37N7O/c1-27(2,3)26-30-21(20-9-10-20)18-24(31-26)33-16-14-32(15-17-33)12-7-5-11-28-25(35)22-19-34-13-6-4-8-23(34)29-22/h4,6,8,13,18-20H,5,7,9-12,14-17H2,1-3H3,(H,28,35)
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8.40n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301847
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2cnccn2)CC1
Show InChI InChI=1S/C26H38F3N9O/c1-25(2,3)23-33-20(26(27,28)29)18-21(34-23)36-12-10-35(11-13-36)9-5-4-6-32-24(39)38-16-14-37(15-17-38)22-19-30-7-8-31-22/h7-8,18-19H,4-6,9-17H2,1-3H3,(H,32,39)
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8.60n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301879
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CCN1CCN(CC1)C(=O)NCCCCN1CCN(CC1)c1cc(nc(n1)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C24H40F3N7O/c1-5-31-10-16-34(17-11-31)22(35)28-8-6-7-9-32-12-14-33(15-13-32)20-18-19(24(25,26)27)29-21(30-20)23(2,3)4/h18H,5-17H2,1-4H3,(H,28,35)
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8.60n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301840
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2cccc(c2)C#N)CC1
Show InChI InChI=1S/C29H39F3N8O/c1-28(2,3)26-35-24(29(30,31)32)20-25(36-26)39-13-11-37(12-14-39)10-5-4-9-34-27(41)40-17-15-38(16-18-40)23-8-6-7-22(19-23)21-33/h6-8,19-20H,4-5,9-18H2,1-3H3,(H,34,41)
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8.70n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50057779
PNG
(CHEMBL3323008 | US9598387, Compound 111 | US996974...)
Show SMILES Cc1cc(nc(n1)C(C)(C)C)N1CCN(CCCCNC(=O)c2cn3ccccc3n2)CC1
Show InChI InChI=1S/C25H35N7O/c1-19-17-22(29-24(27-19)25(2,3)4)31-15-13-30(14-16-31)11-8-6-10-26-23(33)20-18-32-12-7-5-9-21(32)28-20/h5,7,9,12,17-18H,6,8,10-11,13-16H2,1-4H3,(H,26,33)
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9.30n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301918
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)C2CCC(CC2)c2ccccc2)CC1
Show InChI InChI=1S/C30H42F3N5O/c1-29(2,3)28-35-25(30(31,32)33)21-26(36-28)38-19-17-37(18-20-38)16-8-7-15-34-27(39)24-13-11-23(12-14-24)22-9-5-4-6-10-22/h4-6,9-10,21,23-24H,7-8,11-20H2,1-3H3,(H,34,39)
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9.40n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM393962
PNG
(US9969743, 56)
Show SMILES CC(C)(C)c1cc(nc(n1)C(C)(C)C)N1CCN(CCCCNC(=O)N2CCc3c(C2)[nH]c2ccccc32)CC1
Show InChI InChI=1S/C32H47N7O/c1-31(2,3)27-21-28(36-29(35-27)32(4,5)6)38-19-17-37(18-20-38)15-10-9-14-33-30(40)39-16-13-24-23-11-7-8-12-25(23)34-26(24)22-39/h7-8,11-12,21,34H,9-10,13-20,22H2,1-6H3,(H,33,40)
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9.5n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301881
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)N1CCN(CC1)C(=O)NCCCCN1CCN(CC1)c1cc(nc(n1)C(C)C)C(F)(F)F
Show InChI InChI=1S/C24H40F3N7O/c1-18(2)22-29-20(24(25,26)27)17-21(30-22)33-11-9-31(10-12-33)8-6-5-7-28-23(35)34-15-13-32(14-16-34)19(3)4/h17-19H,5-16H2,1-4H3,(H,28,35)
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9.60n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301878
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CN1CCN(CC1)C(=O)NCCCCN1CCN(CC1)c1cc(nc(n1)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C23H38F3N7O/c1-22(2,3)20-28-18(23(24,25)26)17-19(29-20)32-15-11-31(12-16-32)8-6-5-7-27-21(34)33-13-9-30(4)10-14-33/h17H,5-16H2,1-4H3,(H,27,34)
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9.80n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301824
PNG
(4-Phenyl-N-(4-(4-(quinolin-4-yl)piperazin-1-yl)but...)
Show SMILES O=C(NCCCCN1CCN(CC1)c1ccnc2ccccc12)N1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C28H36N6O/c35-28(34-22-20-32(21-23-34)24-8-2-1-3-9-24)30-13-6-7-15-31-16-18-33(19-17-31)27-12-14-29-26-11-5-4-10-25(26)27/h1-5,8-12,14H,6-7,13,15-23H2,(H,30,35)
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9.80n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301890
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCC(CC2)N2CCCCC2)CC1
Show InChI InChI=1S/C28H46F3N7O/c1-27(2,3)25-33-23(28(29,30)31)21-24(34-25)37-19-17-35(18-20-37)12-8-5-11-32-26(39)38-15-9-22(10-16-38)36-13-6-4-7-14-36/h21-22H,4-20H2,1-3H3,(H,32,39)
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9.90n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50057767
PNG
(CHEMBL3323017 | US9598387, Compound 116 | US996974...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)c2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C24H30ClF3N8O/c1-23(2,3)22-31-17(24(26,27)28)14-20(32-22)35-12-10-34(11-13-35)9-5-4-8-29-21(37)16-15-36-19(30-16)7-6-18(25)33-36/h6-7,14-15H,4-5,8-13H2,1-3H3,(H,29,37)
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10.2n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301862
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCC(CC2)c2ccccc2)CC1
Show InChI InChI=1S/C29H41F3N6O/c1-28(2,3)26-34-24(29(30,31)32)21-25(35-26)37-19-17-36(18-20-37)14-8-7-13-33-27(39)38-15-11-23(12-16-38)22-9-5-4-6-10-22/h4-6,9-10,21,23H,7-8,11-20H2,1-3H3,(H,33,39)
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11n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301835
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES COc1ccc(cc1)N1CCN(CC1)C(=O)NCCCCN1CCN(CC1)c1cc(nc(n1)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C29H42F3N7O2/c1-28(2,3)26-34-24(29(30,31)32)21-25(35-26)38-15-13-36(14-16-38)12-6-5-11-33-27(40)39-19-17-37(18-20-39)22-7-9-23(41-4)10-8-22/h7-10,21H,5-6,11-20H2,1-4H3,(H,33,40)
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11.6n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50057768
PNG
(CHEMBL3323015 | US9598387, Compound 114 | US996974...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)c2cn3cccnc3n2)CC1
Show InChI InChI=1S/C24H31F3N8O/c1-23(2,3)21-31-18(24(25,26)27)15-19(32-21)34-13-11-33(12-14-34)9-5-4-7-28-20(36)17-16-35-10-6-8-29-22(35)30-17/h6,8,10,15-16H,4-5,7,9,11-14H2,1-3H3,(H,28,36)
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11.8n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301853
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2Cc3ccccc3C2)CC1
Show InChI InChI=1S/C26H35F3N6O/c1-25(2,3)23-31-21(26(27,28)29)16-22(32-23)34-14-12-33(13-15-34)11-7-6-10-30-24(36)35-17-19-8-4-5-9-20(19)18-35/h4-5,8-9,16H,6-7,10-15,17-18H2,1-3H3,(H,30,36)
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12.2n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301848
PNG
( N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimi...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccnc3ccccc23)CC1
Show InChI InChI=1S/C31H41F3N8O/c1-30(2,3)28-37-26(31(32,33)34)22-27(38-28)41-16-14-39(15-17-41)13-7-6-11-36-29(43)42-20-18-40(19-21-42)25-10-12-35-24-9-5-4-8-23(24)25/h4-5,8-10,12,22H,6-7,11,13-21H2,1-3H3,(H,36,43)
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12.7n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301849
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)C2CC2)CC1
Show InChI InChI=1S/C25H40F3N7O/c1-24(2,3)22-30-20(25(26,27)28)18-21(31-22)34-12-10-32(11-13-34)9-5-4-8-29-23(36)35-16-14-33(15-17-35)19-6-7-19/h18-19H,4-17H2,1-3H3,(H,29,36)
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12.8n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301834
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES COc1cccc(c1)N1CCN(CC1)C(=O)NCCCCN1CCN(CC1)c1cc(nc(n1)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C29H42F3N7O2/c1-28(2,3)26-34-24(29(30,31)32)21-25(35-26)38-14-12-36(13-15-38)11-6-5-10-33-27(40)39-18-16-37(17-19-39)22-8-7-9-23(20-22)41-4/h7-9,20-21H,5-6,10-19H2,1-4H3,(H,33,40)
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13n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301846
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ncccn2)CC1
Show InChI InChI=1S/C26H38F3N9O/c1-25(2,3)22-33-20(26(27,28)29)19-21(34-22)36-13-11-35(12-14-36)10-5-4-7-32-24(39)38-17-15-37(16-18-38)23-30-8-6-9-31-23/h6,8-9,19H,4-5,7,10-18H2,1-3H3,(H,32,39)
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13.7n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301883
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC3CC3)CC2)CC1
Show InChI InChI=1S/C26H42F3N7O/c1-25(2,3)23-31-21(26(27,28)29)18-22(32-23)35-14-10-33(11-15-35)9-5-4-8-30-24(37)36-16-12-34(13-17-36)19-20-6-7-20/h18,20H,4-17,19H2,1-3H3,(H,30,37)
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13.8n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301786
PNG
(4-Phenyl-N-(4-(4-(3-(trifluoromethyl)phenyl)pipera...)
Show SMILES FC(F)(F)c1cccc(c1)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccccc2)CC1
Show InChI InChI=1S/C26H34F3N5O/c27-26(28,29)22-7-6-10-24(21-22)33-15-13-31(14-16-33)12-5-4-11-30-25(35)34-19-17-32(18-20-34)23-8-2-1-3-9-23/h1-3,6-10,21H,4-5,11-20H2,(H,30,35)
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14.2n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301857
PNG
( 4-([1,1′-Biphenyl]-2-yl)-N-(4-(4-(2-(tert-b...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccccc2-c2ccccc2)CC1
Show InChI InChI=1S/C34H44F3N7O/c1-33(2,3)31-39-29(34(35,36)37)25-30(40-31)43-19-17-41(18-20-43)16-10-9-15-38-32(45)44-23-21-42(22-24-44)28-14-8-7-13-27(28)26-11-5-4-6-12-26/h4-8,11-14,25H,9-10,15-24H2,1-3H3,(H,38,45)
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15n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301816
PNG
( N-(4-(4-(2-(tert-Butyl)-6-cyclopropylpyrimidin-4-...)
Show SMILES CC(C)(C)c1nc(cc(n1)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccccc2)CC1)C1CC1
Show InChI InChI=1S/C30H45N7O/c1-30(2,3)28-32-26(24-11-12-24)23-27(33-28)36-17-15-34(16-18-36)14-8-7-13-31-29(38)37-21-19-35(20-22-37)25-9-5-4-6-10-25/h4-6,9-10,23-24H,7-8,11-22H2,1-3H3,(H,31,38)
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15.1n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301821
PNG
( N-(4-(4-(2,6-Di-tert-butylpyrimidin-4-yl)piperazi...)
Show SMILES CC(C)(C)c1cc(nc(n1)C(C)(C)C)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccccc2)CC1
Show InChI InChI=1S/C31H49N7O/c1-30(2,3)26-24-27(34-28(33-26)31(4,5)6)37-18-16-35(17-19-37)15-11-10-14-32-29(39)38-22-20-36(21-23-38)25-12-8-7-9-13-25/h7-9,12-13,24H,10-11,14-23H2,1-6H3,(H,32,39)
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15.1n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301831
PNG
( N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimi...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCC(CC2)(C#N)c2ccccc2)CC1
Show InChI InChI=1S/C30H40F3N7O/c1-28(2,3)26-36-24(30(31,32)33)21-25(37-26)39-19-17-38(18-20-39)14-8-7-13-35-27(41)40-15-11-29(22-34,12-16-40)23-9-5-4-6-10-23/h4-6,9-10,21H,7-8,11-20H2,1-3H3,(H,35,41)
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16n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301839
PNG
( N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimi...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccccc2C#N)CC1
Show InChI InChI=1S/C29H39F3N8O/c1-28(2,3)26-35-24(29(30,31)32)20-25(36-26)39-14-12-37(13-15-39)11-7-6-10-34-27(41)40-18-16-38(17-19-40)23-9-5-4-8-22(23)21-33/h4-5,8-9,20H,6-7,10-19H2,1-3H3,(H,34,41)
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16.6n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301850
PNG
(4-Benzyl-N-(4-(4-(2-(tert-butyl)-6-(trifluoromethy...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(Cc3ccccc3)CC2)CC1
Show InChI InChI=1S/C29H42F3N7O/c1-28(2,3)26-34-24(29(30,31)32)21-25(35-26)38-17-13-36(14-18-38)12-8-7-11-33-27(40)39-19-15-37(16-20-39)22-23-9-5-4-6-10-23/h4-6,9-10,21H,7-8,11-20,22H2,1-3H3,(H,33,40)
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16.7n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301891
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CN1CCC(CC1)N1CCN(CC1)C(=O)NCCCCN1CCN(CC1)c1cc(nc(n1)C(C)(C)C)C(F)(F)F
Show InChI InChI=1S/C28H47F3N8O/c1-27(2,3)25-33-23(28(29,30)31)21-24(34-25)38-15-13-36(14-16-38)10-6-5-9-32-26(40)39-19-17-37(18-20-39)22-7-11-35(4)12-8-22/h21-22H,5-20H2,1-4H3,(H,32,40)
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18n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301864
PNG
( 4-Benzyl-N-(4-(4-(2-(tert-butyl)-6-(trifluorometh...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCC(Cc3ccccc3)CC2)CC1
Show InChI InChI=1S/C30H43F3N6O/c1-29(2,3)27-35-25(30(31,32)33)22-26(36-27)38-19-17-37(18-20-38)14-8-7-13-34-28(40)39-15-11-24(12-16-39)21-23-9-5-4-6-10-23/h4-6,9-10,22,24H,7-8,11-21H2,1-3H3,(H,34,40)
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18.4n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50057778
PNG
(CHEMBL3323009 | US9598387, Compound 122 | US996974...)
Show SMILES CC(C)(C)c1cc(nc(n1)C(C)(C)C)N1CCN(CCCCNC(=O)c2cn3ccccc3n2)CC1
Show InChI InChI=1S/C28H41N7O/c1-27(2,3)22-19-24(32-26(31-22)28(4,5)6)34-17-15-33(16-18-34)13-10-8-12-29-25(36)21-20-35-14-9-7-11-23(35)30-21/h7,9,11,14,19-20H,8,10,12-13,15-18H2,1-6H3,(H,29,36)
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18.8n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301917
PNG
( N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimi...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(C(=O)C2)c2ccccc2)CC1
Show InChI InChI=1S/C28H38F3N7O2/c1-27(2,3)25-33-22(28(29,30)31)19-23(34-25)36-15-13-35(14-16-36)12-8-7-11-32-26(40)37-17-18-38(24(39)20-37)21-9-5-4-6-10-21/h4-6,9-10,19H,7-8,11-18,20H2,1-3H3,(H,32,40)
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19.2n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301877
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2ccnc3cc(Cl)ccc23)CC1
Show InChI InChI=1S/C31H40ClF3N8O/c1-30(2,3)28-38-26(31(33,34)35)21-27(39-28)42-14-12-40(13-15-42)11-5-4-9-37-29(44)43-18-16-41(17-19-43)25-8-10-36-24-20-22(32)6-7-23(24)25/h6-8,10,20-21H,4-5,9,11-19H2,1-3H3,(H,37,44)
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19.2n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM301829
PNG
(N-(4-(4-(2-(tert-Butyl)-6-(trifluoromethyl)pyrimid...)
Show SMILES CC(C)(C)c1nc(cc(n1)C(F)(F)F)N1CCN(CCCCNC(=O)N2CCN(CC2)c2cccc(Cl)c2)CC1
Show InChI InChI=1S/C28H39ClF3N7O/c1-27(2,3)25-34-23(28(30,31)32)20-24(35-25)38-13-11-36(12-14-38)10-5-4-9-33-26(40)39-17-15-37(16-18-39)22-8-6-7-21(29)19-22/h6-8,19-20H,4-5,9-18H2,1-3H3,(H,33,40)
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19.3n/an/an/an/an/an/an/an/a



SOUTHERN RESEARCH INSTITUTE

US Patent


Assay Description
Stably transfected HEK cells expressing the human D2-long and the D3 dopamine receptor were developed using the pIRESneo2 bicistronic expression vect...


US Patent US9969743 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%