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Patent code US9969749

Compile Data Set for Download or QSAR
Found 169 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393974
PNG
(5-(4-{[trans-4- (morpholin-4- yl)cyclohexyl]amino}...)
Show SMILES Oc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H27N5O2/c29-20-11-17(13-24-14-20)16-1-6-22-21(12-16)23(26-15-25-22)27-18-2-4-19(5-3-18)28-7-9-30-10-8-28/h1,6,11-15,18-19,29H,2-5,7-10H2,(H,25,26,27)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394051
PNG
(US9969749, Example 5-1)
Show SMILES Oc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)(F)CC3)c2c1
Show InChI InChI=1S/C24H26F3N5O/c25-22-21(33)12-16(13-28-22)15-1-6-20-19(11-15)23(30-14-29-20)31-17-2-4-18(5-3-17)32-9-7-24(26,27)8-10-32/h1,6,11-14,17-18,33H,2-5,7-10H2,(H,29,30,31)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394067
PNG
(5-(4-{[trans-4-(4,4- difluoropiperidin-1- yl)cyclo...)
Show SMILES Oc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)(F)CC3)c2c1
Show InChI InChI=1S/C24H27F2N5O/c25-24(26)7-9-31(10-8-24)19-4-2-18(3-5-19)30-23-21-12-16(1-6-22(21)28-15-29-23)17-11-20(32)14-27-13-17/h1,6,11-15,18-19,32H,2-5,7-10H2,(H,28,29,30)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394068
PNG
(5-(4-{[trans-4-(4- fluoropiperidin-1- yl)cyclohexy...)
Show SMILES Oc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)CC3)c2c1
Show InChI InChI=1S/C24H28FN5O/c25-18-7-9-30(10-8-18)20-4-2-19(3-5-20)29-24-22-12-16(1-6-23(22)27-15-28-24)17-11-21(31)14-26-13-17/h1,6,11-15,18-20,31H,2-5,7-10H2,(H,27,28,29)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394063
PNG
(2-fluoro-5-(4-{[trans-4- (4-fluoropiperidin-1- yl)...)
Show SMILES Oc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)CC3)c2c1
Show InChI InChI=1S/C24H27F2N5O/c25-17-7-9-31(10-8-17)19-4-2-18(3-5-19)30-24-20-11-15(1-6-21(20)28-14-29-24)16-12-22(32)23(26)27-13-16/h1,6,11-14,17-19,32H,2-5,7-10H2,(H,28,29,30)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394054
PNG
(5-[4-({trans-4-[(2- methoxyethyl)amino]cyclo- hexy...)
Show SMILES COCCN[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(O)c1
Show InChI InChI=1S/C22H27N5O2/c1-29-9-8-24-17-3-5-18(6-4-17)27-22-20-11-15(2-7-21(20)25-14-26-22)16-10-19(28)13-23-12-16/h2,7,10-14,17-18,24,28H,3-6,8-9H2,1H3,(H,25,26,27)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394042
PNG
(2-fluoro-5-(4-{[trans-4- (morpholin-4- yl)cyclohex...)
Show SMILES Oc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H26FN5O2/c24-22-21(30)12-16(13-25-22)15-1-6-20-19(11-15)23(27-14-26-20)28-17-2-4-18(5-3-17)29-7-9-31-10-8-29/h1,6,11-14,17-18,30H,2-5,7-10H2,(H,26,27,28)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394056
PNG
(5-[4-({trans-4-[(2R,6S)- 2,6-dimethylmorpholin-4- ...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(O)c1
Show InChI InChI=1S/C25H31N5O2/c1-16-13-30(14-17(2)32-16)21-6-4-20(5-7-21)29-25-23-10-18(3-8-24(23)27-15-28-25)19-9-22(31)12-26-11-19/h3,8-12,15-17,20-21,31H,4-7,13-14H2,1-2H3,(H,27,28,29)/t16-,17+,20-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394074
PNG
(6-(5-amino-6- fluoropyridin-3-yl)-N- {trans-4-[(2R...)
Show SMILES C[C@@H]1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(F)c(N)c1
Show InChI InChI=1S/C24H29FN6O/c1-15-13-31(8-9-32-15)19-5-3-18(4-6-19)30-24-20-10-16(2-7-22(20)28-14-29-24)17-11-21(26)23(25)27-12-17/h2,7,10-12,14-15,18-19H,3-6,8-9,13,26H2,1H3,(H,28,29,30)/t15-,18-,19-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393916
PNG
(US9969749, Example 1-10 | cis or trans-N,N- dimeth...)
Show SMILES CN(C)C1CCC(CC1)Nc1ncnc2ccc(cc12)C(=C\N)\C=N
Show InChI InChI=1S/C19H26N6/c1-25(2)16-6-4-15(5-7-16)24-19-17-9-13(14(10-20)11-21)3-8-18(17)22-12-23-19/h3,8-12,15-16,20H,4-7,21H2,1-2H3,(H,22,23,24)/b14-11+,20-10?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394064
PNG
(2-fluoro-5-[4-({trans-4- [4- (methylsulfonyl)piper...)
Show SMILES CS(=O)N1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(F)c(O)c1
Show InChI InChI=1S/C24H29FN6O2S/c1-34(33)31-10-8-30(9-11-31)19-5-3-18(4-6-19)29-24-20-12-16(2-7-21(20)27-15-28-24)17-13-22(32)23(25)26-14-17/h2,7,12-15,18-19,32H,3-6,8-11H2,1H3,(H,27,28,29)/t18-,19-,34?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394081
PNG
(6-[6-fluoro-5- (methylamino)pyridin-3- yl]-N-{tran...)
Show SMILES CNc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCO[C@@H](C)C3)c2c1
Show InChI InChI=1S/C25H31FN6O/c1-16-14-32(9-10-33-16)20-6-4-19(5-7-20)31-25-21-11-17(3-8-22(21)29-15-30-25)18-12-23(27-2)24(26)28-13-18/h3,8,11-13,15-16,19-20,27H,4-7,9-10,14H2,1-2H3,(H,29,30,31)/t16-,19-,20-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394019
PNG
(6-(5-amino-6- fluoropyridin-3-yl)-N- (trans-4-morp...)
Show SMILES Nc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H27FN6O/c24-22-20(25)12-16(13-26-22)15-1-6-21-19(11-15)23(28-14-27-21)29-17-2-4-18(5-3-17)30-7-9-31-10-8-30/h1,6,11-14,17-18H,2-5,7-10,25H2,(H,27,28,29)/t17-,18-
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US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394066
PNG
(6-(5-amino-6- fluoropyridin-3-yl)-N- [trans-4-(4- ...)
Show SMILES Nc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)CC3)c2c1
Show InChI InChI=1S/C24H28F2N6/c25-17-7-9-32(10-8-17)19-4-2-18(3-5-19)31-24-20-11-15(1-6-22(20)29-14-30-24)16-12-21(27)23(26)28-13-16/h1,6,11-14,17-19H,2-5,7-10,27H2,(H,29,30,31)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394069
PNG
(6-(5-amino-6- fluoropyridin-3-yl)-N- {trans-4-[(2R...)
Show SMILES C[C@H]1CN(C[C@@H](C)O1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(F)c(N)c1
Show InChI InChI=1S/C25H31FN6O/c1-15-12-32(13-16(2)33-15)20-6-4-19(5-7-20)31-25-21-9-17(3-8-23(21)29-14-30-25)18-10-22(27)24(26)28-11-18/h3,8-11,14-16,19-20H,4-7,12-13,27H2,1-2H3,(H,29,30,31)/t15-,16+,19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394053
PNG
(5-[4-({trans-4- [cyclopropyl(methyl)amino] cyclohe...)
Show SMILES CN(C1CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(O)c1
Show InChI InChI=1S/C23H27N5O/c1-28(19-7-8-19)18-5-3-17(4-6-18)27-23-21-11-15(2-9-22(21)25-14-26-23)16-10-20(29)13-24-12-16/h2,9-14,17-19,29H,3-8H2,1H3,(H,25,26,27)/t17-,18-
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US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394018
PNG
(2-chloro-5-{4-[(trans-4- morpholin-4- ylcyclohexyl...)
Show SMILES Oc1cc(cnc1Cl)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H26ClN5O2/c24-22-21(30)12-16(13-25-22)15-1-6-20-19(11-15)23(27-14-26-20)28-17-2-4-18(5-3-17)29-7-9-31-10-8-29/h1,6,11-14,17-18,30H,2-5,7-10H2,(H,26,27,28)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394049
PNG
(US9969749, Example 3-1)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(O)c1
Show InChI InChI=1S/C21H25N5O/c1-26(2)17-6-4-16(5-7-17)25-21-19-10-14(3-8-20(19)23-13-24-21)15-9-18(27)12-22-11-15/h3,8-13,16-17,27H,4-7H2,1-2H3,(H,23,24,25)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394012
PNG
(2-chloro-5-(4-{[trans-4- (morpholin-4- yl)cyclohex...)
Show SMILES Oc1cc(cnc1Cl)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H26ClN5O2/c24-22-21(30)12-16(13-25-22)15-1-6-20-19(11-15)23(27-14-26-20)28-17-2-4-18(5-3-17)29-7-9-31-10-8-29/h1,6,11-14,17-18,30H,2-5,7-10H2,(H,26,27,28)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393982
PNG
(6-(5-aminopyridin-3- yl)-N-(trans-4- morpholin-4- ...)
Show SMILES Nc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H28N6O/c24-18-11-17(13-25-14-18)16-1-6-22-21(12-16)23(27-15-26-22)28-19-2-4-20(5-3-19)29-7-9-30-10-8-29/h1,6,11-15,19-20H,2-5,7-10,24H2,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394075
PNG
(6-(5-amino-6- fluoropyridin-3-yl)-N- {trans-4-[(2S...)
Show SMILES C[C@H]1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(F)c(N)c1
Show InChI InChI=1S/C24H29FN6O/c1-15-13-31(8-9-32-15)19-5-3-18(4-6-19)30-24-20-10-16(2-7-22(20)28-14-29-24)17-11-21(26)23(25)27-12-17/h2,7,10-12,14-15,18-19H,3-6,8-9,13,26H2,1H3,(H,28,29,30)/t15-,18-,19-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394080
PNG
(6-[6-fluoro-5- (methylamino)pyridin-3- yl]-N-{tran...)
Show SMILES CNc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCO[C@H](C)C3)c2c1
Show InChI InChI=1S/C25H31FN6O/c1-16-14-32(9-10-33-16)20-6-4-19(5-7-20)31-25-21-11-17(3-8-22(21)29-15-30-25)18-12-23(27-2)24(26)28-13-18/h3,8,11-13,15-16,19-20,27H,4-7,9-10,14H2,1-2H3,(H,29,30,31)/t16-,19-,20-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394044
PNG
(6-[6-fluoro-5- (methylamino)pyridin-3- yl]-N-[tran...)
Show SMILES CNc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H29FN6O/c1-26-22-13-17(14-27-23(22)25)16-2-7-21-20(12-16)24(29-15-28-21)30-18-3-5-19(6-4-18)31-8-10-32-11-9-31/h2,7,12-15,18-19,26H,3-6,8-11H2,1H3,(H,28,29,30)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393993
PNG
(5-{7-fluoro-4-[(trans-4- morpholin-4- ylcyclohexyl...)
Show SMILES Oc1cncc(c1)-c1cc2c(N[C@H]3CC[C@@H](CC3)N3CCOCC3)ncnc2cc1F
Show InChI InChI=1S/C23H26FN5O2/c24-21-11-22-20(10-19(21)15-9-18(30)13-25-12-15)23(27-14-26-22)28-16-1-3-17(4-2-16)29-5-7-31-8-6-29/h9-14,16-17,30H,1-8H2,(H,26,27,28)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394076
PNG
(N-{trans-4-[(2R,6S)-2,6- dimethylmorpholin-4- yl]c...)
Show SMILES CNc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3C[C@H](C)O[C@H](C)C3)c2c1
Show InChI InChI=1S/C26H33FN6O/c1-16-13-33(14-17(2)34-16)21-7-5-20(6-8-21)32-26-22-10-18(4-9-23(22)30-15-31-26)19-11-24(28-3)25(27)29-12-19/h4,9-12,15-17,20-21,28H,5-8,13-14H2,1-3H3,(H,30,31,32)/t16-,17+,20-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394052
PNG
(5-(4-{[trans-4-(3- methoxyazetidin-1- yl)cyclohexy...)
Show SMILES COC1CN(C1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(O)c1
Show InChI InChI=1S/C23H27N5O2/c1-30-20-12-28(13-20)18-5-3-17(4-6-18)27-23-21-9-15(2-7-22(21)25-14-26-23)16-8-19(29)11-24-10-16/h2,7-11,14,17-18,20,29H,3-6,12-13H2,1H3,(H,25,26,27)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394055
PNG
(5-(4-{[trans-4-(4- methylpiperazin-1- yl)cyclohexy...)
Show SMILES CN1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(O)c1
Show InChI InChI=1S/C24H30N6O/c1-29-8-10-30(11-9-29)20-5-3-19(4-6-20)28-24-22-13-17(2-7-23(22)26-16-27-24)18-12-21(31)15-25-14-18/h2,7,12-16,19-20,31H,3-6,8-11H2,1H3,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394078
PNG
(US9969749, Example 5-28 | cyclopropyl{4-[trans-4- ...)
Show SMILES CNc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCN(CC3)C(=O)C3CC3)c2c1
Show InChI InChI=1S/C28H34FN7O/c1-30-25-15-20(16-31-26(25)29)19-4-9-24-23(14-19)27(33-17-32-24)34-21-5-7-22(8-6-21)35-10-12-36(13-11-35)28(37)18-2-3-18/h4,9,14-18,21-22,30H,2-3,5-8,10-13H2,1H3,(H,32,33,34)/t21-,22-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394065
PNG
(6-(5-amino-6- fluoropyridin-3-yl)-N- [trans-4-(4,4...)
Show SMILES Nc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)(F)CC3)c2c1
Show InChI InChI=1S/C24H27F3N6/c25-22-20(28)12-16(13-29-22)15-1-6-21-19(11-15)23(31-14-30-21)32-17-2-4-18(5-3-17)33-9-7-24(26,27)8-10-33/h1,6,11-14,17-18H,2-5,7-10,28H2,(H,30,31,32)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394061
PNG
(6-[5- (methylamino)pyridin-3- yl]-N-{trans-4-[(3R)...)
Show SMILES CNc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC[C@H](CN4CCOCC4)C3)c2c1
Show InChI InChI=1S/C30H41N7O/c1-31-26-15-24(17-32-18-26)23-4-9-29-28(16-23)30(34-21-33-29)35-25-5-7-27(8-6-25)37-10-2-3-22(20-37)19-36-11-13-38-14-12-36/h4,9,15-18,21-22,25,27,31H,2-3,5-8,10-14,19-20H2,1H3,(H,33,34,35)/t22-,25-,27-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394040
PNG
(6-(isoxazol-4-yl)-N- [trans-4-(morpholin-4- yl)cyc...)
Show SMILES C1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnoc1
Show InChI InChI=1S/C21H25N5O2/c1-6-20-19(11-15(1)16-12-24-28-13-16)21(23-14-22-20)25-17-2-4-18(5-3-17)26-7-9-27-10-8-26/h1,6,11-14,17-18H,2-5,7-10H2,(H,22,23,25)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394077
PNG
(N-[trans-4-(4,4- difluoropiperidin-1- yl)cyclohexy...)
Show SMILES CNc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)(F)CC3)c2c1
Show InChI InChI=1S/C25H29F3N6/c1-29-22-13-17(14-30-23(22)26)16-2-7-21-20(12-16)24(32-15-31-21)33-18-3-5-19(6-4-18)34-10-8-25(27,28)9-11-34/h2,7,12-15,18-19,29H,3-6,8-11H2,1H3,(H,31,32,33)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394071
PNG
(6-(5-amino-6- fluoropyridin-3-yl)-N- {trans-4-[3-(...)
Show SMILES Nc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCCC(CN4CCOCC4)C3)c2c1
Show InChI InChI=1S/C29H38FN7O/c30-28-26(31)15-22(16-32-28)21-3-8-27-25(14-21)29(34-19-33-27)35-23-4-6-24(7-5-23)37-9-1-2-20(18-37)17-36-10-12-38-13-11-36/h3,8,14-16,19-20,23-24H,1-2,4-7,9-13,17-18,31H2,(H,33,34,35)/t20?,23-,24-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393990
PNG
(6-[5- (methylamino)pyridin- 3-yl]-N-(trans-4- morp...)
Show SMILES CNc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H30N6O/c1-25-20-12-18(14-26-15-20)17-2-7-23-22(13-17)24(28-16-27-23)29-19-3-5-21(6-4-19)30-8-10-31-11-9-30/h2,7,12-16,19,21,25H,3-6,8-11H2,1H3,(H,27,28,29)/t19-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393991
PNG
(N-(trans-4-morpholin-4- ylcyclohexyl)-6-(1H- pyraz...)
Show SMILES N\C=C(/C=N)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C21H28N6O/c22-12-16(13-23)15-1-6-20-19(11-15)21(25-14-24-20)26-17-2-4-18(5-3-17)27-7-9-28-10-8-27/h1,6,11-14,17-18,22H,2-5,7-10,23H2,(H,24,25,26)/b16-13+,22-12?/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393989
PNG
(7-fluoro-N-(trans-4- morpholin-4- ylcyclohexyl)-6-...)
Show SMILES N\C=C(/C=N)c1cc2c(N[C@H]3CC[C@@H](CC3)N3CCOCC3)ncnc2cc1F
Show InChI InChI=1S/C21H27FN6O/c22-19-10-20-18(9-17(19)14(11-23)12-24)21(26-13-25-20)27-15-1-3-16(4-2-15)28-5-7-29-8-6-28/h9-13,15-16,23H,1-8,24H2,(H,25,26,27)/b14-12+,23-11?/t15-,16-
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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394079
PNG
(6-[6-fluoro-5- (methylamino)pyridin-3- yl]-N-[tran...)
Show SMILES CNc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)CC3)c2c1
Show InChI InChI=1S/C25H30F2N6/c1-28-23-13-17(14-29-24(23)27)16-2-7-22-21(12-16)25(31-15-30-22)32-19-3-5-20(6-4-19)33-10-8-18(26)9-11-33/h2,7,12-15,18-20,28H,3-6,8-11H2,1H3,(H,30,31,32)/t19-,20-
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US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393972
PNG
(3-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cc(O)cc(F)c1
Show InChI InChI=1S/C22H25FN4O/c1-27(2)18-6-4-17(5-7-18)26-22-20-11-14(3-8-21(20)24-13-25-22)15-9-16(23)12-19(28)10-15/h3,8-13,17-18,28H,4-7H2,1-2H3,(H,24,25,26)/t17-,18-
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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393954
PNG
(N-[trans-4-(morpholin- 4-yl)cyclohexyl]-6- (pyrimi...)
Show SMILES C1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncnc1
Show InChI InChI=1S/C22H26N6O/c1-6-21-20(11-16(1)17-12-23-14-24-13-17)22(26-15-25-21)27-18-2-4-19(5-3-18)28-7-9-29-10-8-28/h1,6,11-15,18-19H,2-5,7-10H2,(H,25,26,27)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394058
PNG
(N-[trans-4-(4,4- difluoropiperidin-1- yl)cyclohexy...)
Show SMILES CNc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)(F)CC3)c2c1
Show InChI InChI=1S/C25H30F2N6/c1-28-20-12-18(14-29-15-20)17-2-7-23-22(13-17)24(31-16-30-23)32-19-3-5-21(6-4-19)33-10-8-25(26,27)9-11-33/h2,7,12-16,19,21,28H,3-6,8-11H2,1H3,(H,30,31,32)/t19-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393983
PNG
(6-(2-aminopyridin-4- yl)-N-(trans-4- morpholin-4- ...)
Show SMILES Nc1cc(ccn1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H28N6O/c24-22-14-17(7-8-25-22)16-1-6-21-20(13-16)23(27-15-26-21)28-18-2-4-19(5-3-18)29-9-11-30-12-10-29/h1,6-8,13-15,18-19H,2-5,9-12H2,(H2,24,25)(H,26,27,28)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393932
PNG
(US9969749, Example 1-25 | trans-N,N-dimethyl-N'- [...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncnc1
Show InChI InChI=1S/C20H24N6/c1-26(2)17-6-4-16(5-7-17)25-20-18-9-14(15-10-21-12-22-11-15)3-8-19(18)23-13-24-20/h3,8-13,16-17H,4-7H2,1-2H3,(H,23,24,25)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394059
PNG
(N-[trans-4-(4- fluoropiperidin-1- yl)cyclohexyl]-6...)
Show SMILES CNc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(F)CC3)c2c1
Show InChI InChI=1S/C25H31FN6/c1-27-21-12-18(14-28-15-21)17-2-7-24-23(13-17)25(30-16-29-24)31-20-3-5-22(6-4-20)32-10-8-19(26)9-11-32/h2,7,12-16,19-20,22,27H,3-6,8-11H2,1H3,(H,29,30,31)/t20-,22-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393973
PNG
(5-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cc(O)c(F)c(F)c1
Show InChI InChI=1S/C22H24F2N4O/c1-28(2)16-6-4-15(5-7-16)27-22-17-9-13(3-8-19(17)25-12-26-22)14-10-18(23)21(24)20(29)11-14/h3,8-12,15-16,29H,4-7H2,1-2H3,(H,25,26,27)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394070
PNG
(6-(5-amino-6- fluoropyridin-3-yl)-N- {trans-4-[4- ...)
Show SMILES CSN1CCN(CC1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(F)c(N)c1
Show InChI InChI=1S/C24H30FN7S/c1-33-32-10-8-31(9-11-32)19-5-3-18(4-6-19)30-24-20-12-16(2-7-22(20)28-15-29-24)17-13-21(26)23(25)27-14-17/h2,7,12-15,18-19H,3-6,8-11,26H2,1H3,(H,28,29,30)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394072
PNG
(6-(5-amino-6- fluoropyridin-3-yl)-N- {trans-4-[(2R...)
Show SMILES Nc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCO[C@@H](CF)C3)c2c1
Show InChI InChI=1S/C24H28F2N6O/c25-11-19-13-32(7-8-33-19)18-4-2-17(3-5-18)31-24-20-9-15(1-6-22(20)29-14-30-24)16-10-21(27)23(26)28-12-16/h1,6,9-10,12,14,17-19H,2-5,7-8,11,13,27H2,(H,29,30,31)/t17-,18-,19-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393979
PNG
(2,3-difluoro-5-{4- [(trans-4-morpholin-4- ylcycloh...)
Show SMILES Oc1cc(cc(F)c1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H26F2N4O2/c25-20-12-16(13-22(31)23(20)26)15-1-6-21-19(11-15)24(28-14-27-21)29-17-2-4-18(5-3-17)30-7-9-32-10-8-30/h1,6,11-14,17-18,31H,2-5,7-10H2,(H,27,28,29)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394062
PNG
(6-[5- (methylamino)pyridin-3- yl]-N-{trans-4-[(3S)...)
Show SMILES CNc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC[C@@H](CN4CCOCC4)C3)c2c1
Show InChI InChI=1S/C30H41N7O/c1-31-26-15-24(17-32-18-26)23-4-9-29-28(16-23)30(34-21-33-29)35-25-5-7-27(8-6-25)37-10-2-3-22(20-37)19-36-11-13-38-14-12-36/h4,9,15-18,21-22,25,27,31H,2-3,5-8,10-14,19-20H2,1H3,(H,33,34,35)/t22-,25-,27-/m0/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393915
PNG
(US9969749, Example 1-9 | trans-N,N-dimethyl-N'- [6...)
Show SMILES CN\C=C(/C=N)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C20H28N6/c1-22-12-15(11-21)14-4-9-19-18(10-14)20(24-13-23-19)25-16-5-7-17(8-6-16)26(2)3/h4,9-13,16-17,21-22H,5-8H2,1-3H3,(H,23,24,25)/b15-12+,21-11?/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393975
PNG
(3-fluoro-5-{4-[(trans- 4-morpholin-4- ylcyclohexyl...)
Show SMILES Oc1cc(F)cc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H27FN4O2/c25-18-11-17(12-21(30)14-18)16-1-6-23-22(13-16)24(27-15-26-23)28-19-2-4-20(5-3-19)29-7-9-31-10-8-29/h1,6,11-15,19-20,30H,2-5,7-10H2,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393981
PNG
(3-{4-[(trans-4- morpholin-4- ylcyclohexyl)amino] q...)
Show SMILES Oc1cccc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H28N4O2/c29-21-3-1-2-17(14-21)18-4-9-23-22(15-18)24(26-16-25-23)27-19-5-7-20(8-6-19)28-10-12-30-13-11-28/h1-4,9,14-16,19-20,29H,5-8,10-13H2,(H,25,26,27)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394073
PNG
(6-(5-amino-6- fluoropyridin-3-yl)-N- {trans-4-[(2S...)
Show SMILES Nc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCO[C@H](CF)C3)c2c1
Show InChI InChI=1S/C24H28F2N6O/c25-11-19-13-32(7-8-33-19)18-4-2-17(3-5-18)31-24-20-9-15(1-6-22(20)29-14-30-24)16-10-21(27)23(26)28-12-16/h1,6,9-10,12,14,17-19H,2-5,7-8,11,13,27H2,(H,29,30,31)/t17-,18-,19-/m1/s1
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393935
PNG
(5-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1ccc(O)nc1
Show InChI InChI=1S/C21H25N5O/c1-26(2)17-7-5-16(6-8-17)25-21-18-11-14(3-9-19(18)23-13-24-21)15-4-10-20(27)22-12-15/h3-4,9-13,16-17H,5-8H2,1-2H3,(H,22,27)(H,23,24,25)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394022
PNG
(4-{4-[(trans-4- morpholin-4- ylcyclohexyl)amino] q...)
Show SMILES N#Cc1n[nH]cc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1/C22H25N7O/c23-12-21-19(13-26-28-21)15-1-6-20-18(11-15)22(25-14-24-20)27-16-2-4-17(5-3-16)29-7-9-30-10-8-29/h1,6,11,13-14,16-17H,2-5,7-10H2,(H,26,28)(H,24,25,27)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394057
PNG
(6-[5- (methylamino)pyridin-3- yl]-N-{trans-4-[4- (...)
Show SMILES CNc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCN(CC3)SC)c2c1
Show InChI InChI=1S/C25H33N7S/c1-26-21-13-19(15-27-16-21)18-3-8-24-23(14-18)25(29-17-28-24)30-20-4-6-22(7-5-20)31-9-11-32(33-2)12-10-31/h3,8,13-17,20,22,26H,4-7,9-12H2,1-2H3,(H,28,29,30)/t20-,22-
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Merck Sharp & Dohme Corp.

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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394060
PNG
(6-[5- (methylamino)pyridin-3- yl]-N-{trans-4-[4- (...)
Show SMILES CNc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCC(CN4CCOCC4)CC3)c2c1
Show InChI InChI=1S/C30H41N7O/c1-31-26-16-24(18-32-19-26)23-2-7-29-28(17-23)30(34-21-33-29)35-25-3-5-27(6-4-25)37-10-8-22(9-11-37)20-36-12-14-38-15-13-36/h2,7,16-19,21-22,25,27,31H,3-6,8-15,20H2,1H3,(H,33,34,35)/t25-,27-
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Merck Sharp & Dohme Corp.

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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393955
PNG
(N-[trans-4-(morpholin- 4-yl)cyclohexyl]-6- (pyridi...)
Show SMILES C1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1ccncc1
Show InChI InChI=1S/C23H27N5O/c1-6-22-21(15-18(1)17-7-9-24-10-8-17)23(26-16-25-22)27-19-2-4-20(5-3-19)28-11-13-29-14-12-28/h1,6-10,15-16,19-20H,2-5,11-14H2,(H,25,26,27)/t19-,20-
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Merck Sharp & Dohme Corp.

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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393939
PNG
(US9969749, Example 1-32 | trans-N'-6-(isoxazol-4- ...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C(=C\O)\C=N
Show InChI InChI=1S/C19H25N5O/c1-24(2)16-6-4-15(5-7-16)23-19-17-9-13(14(10-20)11-25)3-8-18(17)21-12-22-19/h3,8-12,15-16,20,25H,4-7H2,1-2H3,(H,21,22,23)/b14-11+,20-10?/t15-,16-
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n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394008
PNG
(6-(isoxazol-4-yl)-N- [trans-4-(morpholin-4- yl)cyc...)
Show SMILES O\C=C(/C=N)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C21H27N5O2/c22-12-16(13-27)15-1-6-20-19(11-15)21(24-14-23-20)25-17-2-4-18(5-3-17)26-7-9-28-10-8-26/h1,6,11-14,17-18,22,27H,2-5,7-10H2,(H,23,24,25)/b16-13+,22-12?/t17-,18-
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n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393940
PNG
(5-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(O)nc1
Show InChI InChI=1S/C20H24N6O/c1-26(2)16-6-4-15(5-7-16)25-19-17-9-13(3-8-18(17)23-12-24-19)14-10-21-20(27)22-11-14/h3,8-12,15-16H,4-7H2,1-2H3,(H,21,22,27)(H,23,24,25)/t15-,16-
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n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393992
PNG
(6-(3-aminophenyl)-N- (trans-4-morpholin-4- ylcyclo...)
Show SMILES Nc1cccc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H29N5O/c25-19-3-1-2-17(14-19)18-4-9-23-22(15-18)24(27-16-26-23)28-20-5-7-21(8-6-20)29-10-12-30-13-11-29/h1-4,9,14-16,20-21H,5-8,10-13,25H2,(H,26,27,28)/t20-,21-
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n/an/a 9n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393994
PNG
(6-(5-aminopyridin-3- yl)-7-fluoro-N-(trans-4- morp...)
Show SMILES Nc1cncc(c1)-c1cc2c(N[C@H]3CC[C@@H](CC3)N3CCOCC3)ncnc2cc1F
Show InChI InChI=1S/C23H27FN6O/c24-21-11-22-20(10-19(21)15-9-16(25)13-26-12-15)23(28-14-27-22)29-17-1-3-18(4-2-17)30-5-7-31-8-6-30/h9-14,17-18H,1-8,25H2,(H,27,28,29)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394048
PNG
(6-(5-amino-6- chloropyridin-3-yl)-N- [trans-4-(mor...)
Show SMILES Nc1cc(cnc1Cl)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H27ClN6O/c24-22-20(25)12-16(13-26-22)15-1-6-21-19(11-15)23(28-14-27-21)29-17-2-4-18(5-3-17)30-7-9-31-10-8-30/h1,6,11-14,17-18H,2-5,7-10,25H2,(H,27,28,29)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394005
PNG
(US9969749, Example 1-94 | [5-(4-{[trans-4- (morpho...)
Show SMILES OCc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H29N5O2/c30-15-17-11-19(14-25-13-17)18-1-6-23-22(12-18)24(27-16-26-23)28-20-2-4-21(5-3-20)29-7-9-31-10-8-29/h1,6,11-14,16,20-21,30H,2-5,7-10,15H2,(H,26,27,28)/t20-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393941
PNG
(US9969749, Example 1-34 | trans-N'-[6-(3- fluoropy...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1ccncc1F
Show InChI InChI=1S/C21H24FN5/c1-27(2)16-6-4-15(5-7-16)26-21-18-11-14(3-8-20(18)24-13-25-21)17-9-10-23-12-19(17)22/h3,8-13,15-16H,4-7H2,1-2H3,(H,24,25,26)/t15-,16-
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n/an/a 11n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393909
PNG
(US9969749, Example 1-3 | US9969749, Example 1-6 | ...)
Show SMILES CN(C)C1CCC(CC1)Nc1ncnc2ccc(cc12)-c1ccncc1
Show InChI InChI=1S/C21H25N5/c1-26(2)18-6-4-17(5-7-18)25-21-19-13-16(15-9-11-22-12-10-15)3-8-20(19)23-14-24-21/h3,8-14,17-18H,4-7H2,1-2H3,(H,23,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393949
PNG
(US9969749, Example 1-42 | trans-N'-{6-[2- (cyclopr...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(NC2CC2)nc1
Show InChI InChI=1S/C23H29N7/c1-30(2)19-8-6-17(7-9-19)28-22-20-11-15(3-10-21(20)26-14-27-22)16-12-24-23(25-13-16)29-18-4-5-18/h3,10-14,17-19H,4-9H2,1-2H3,(H,24,25,29)(H,26,27,28)/t17-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394011
PNG
(6-(5-chloropyridin-3- yl)-N-[trans-4- (morpholin-4...)
Show SMILES Clc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H26ClN5O/c24-18-11-17(13-25-14-18)16-1-6-22-21(12-16)23(27-15-26-22)28-19-2-4-20(5-3-19)29-7-9-30-10-8-29/h1,6,11-15,19-20H,2-5,7-10H2,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393957
PNG
(US9969749, Example 1-50 | trans-N,N-dimethyl-N'- [...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1ccnnc1
Show InChI InChI=1S/C20H24N6/c1-26(2)17-6-4-16(5-7-17)25-20-18-11-14(15-9-10-23-24-12-15)3-8-19(18)21-13-22-20/h3,8-13,16-17H,4-7H2,1-2H3,(H,21,22,25)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394021
PNG
(6-(4-fluoro-1H-pyrazol- 3-yl)-N-(trans-4- morpholi...)
Show SMILES Fc1c[nH]nc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1/C21H25FN6O/c22-18-12-25-27-20(18)14-1-6-19-17(11-14)21(24-13-23-19)26-15-2-4-16(5-3-15)28-7-9-29-10-8-28/h1,6,11-13,15-16H,2-5,7-10H2,(H,25,27)(H,23,24,26)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394046
PNG
(6-(5,6-difluoropyridin-3- yl)-N-[trans-4- (morphol...)
Show SMILES Fc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H25F2N5O/c24-20-12-16(13-26-22(20)25)15-1-6-21-19(11-15)23(28-14-27-21)29-17-2-4-18(5-3-17)30-7-9-31-10-8-30/h1,6,11-14,17-18H,2-5,7-10H2,(H,27,28,29)/t17-,18-
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n/an/a 13n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393910
PNG
(US9969749, Example 1-4 | US9969749, Example 1-7 | ...)
Show SMILES CN(C)C1CCC(CC1)Nc1ncnc2ccc(cc12)-c1cccnc1
Show InChI InChI=1S/C21H25N5/c1-26(2)18-8-6-17(7-9-18)25-21-19-12-15(16-4-3-11-22-13-16)5-10-20(19)23-14-24-21/h3-5,10-14,17-18H,6-9H2,1-2H3,(H,23,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393976
PNG
(4-{4-[(trans-4- morpholin-4- ylcyclohexyl)amino] q...)
Show SMILES Oc1cc(ccn1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H27N5O2/c29-22-14-17(7-8-24-22)16-1-6-21-20(13-16)23(26-15-25-21)27-18-2-4-19(5-3-18)28-9-11-30-12-10-28/h1,6-8,13-15,18-19H,2-5,9-12H2,(H,24,29)(H,25,26,27)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393996
PNG
(7-fluoro-N-(trans-4- morpholin-4- ylcyclohexyl)-6-...)
Show SMILES Fc1cc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2cc1-c1cncnc1
Show InChI InChI=1S/C22H25FN6O/c23-20-10-21-19(9-18(20)15-11-24-13-25-12-15)22(27-14-26-21)28-16-1-3-17(4-2-16)29-5-7-30-8-6-29/h9-14,16-17H,1-8H2,(H,26,27,28)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393980
PNG
(6-(5-amino-6- methoxypyridin-3-yl)- N-(trans-4-mor...)
Show SMILES COc1ncc(cc1N)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H30N6O2/c1-31-24-21(25)13-17(14-26-24)16-2-7-22-20(12-16)23(28-15-27-22)29-18-3-5-19(6-4-18)30-8-10-32-11-9-30/h2,7,12-15,18-19H,3-6,8-11,25H2,1H3,(H,27,28,29)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393918
PNG
(US9969749, Example 1-12 | trans-N,N-dimethyl-N'- [...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C(=N)\C=C/N
Show InChI InChI=1S/C19H26N6/c1-25(2)15-6-4-14(5-7-15)24-19-16-11-13(17(21)9-10-20)3-8-18(16)22-12-23-19/h3,8-12,14-15,21H,4-7,20H2,1-2H3,(H,22,23,24)/b10-9-,21-17?/t14-,15-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393998
PNG
(6-(2-methylpyrimidin-5- yl)-N-[trans-4- (morpholin...)
Show SMILES Cc1ncc(cn1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H28N6O/c1-16-24-13-18(14-25-16)17-2-7-22-21(12-17)23(27-15-26-22)28-19-3-5-20(6-4-19)29-8-10-30-11-9-29/h2,7,12-15,19-20H,3-6,8-11H2,1H3,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393978
PNG
(6-(5-methoxypyridin-3- yl)-N-[trans-4- (morpholin-...)
Show SMILES COc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H29N5O2/c1-30-21-12-18(14-25-15-21)17-2-7-23-22(13-17)24(27-16-26-23)28-19-3-5-20(6-4-19)29-8-10-31-11-9-29/h2,7,12-16,19-20H,3-6,8-11H2,1H3,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393908
PNG
(US9969749, Example 1-2 | US9969749, Example 1-5 | ...)
Show SMILES CN(C)C1CCC(CC1)Nc1ncnc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C22H26N4/c1-26(2)19-11-9-18(10-12-19)25-22-20-14-17(16-6-4-3-5-7-16)8-13-21(20)23-15-24-22/h3-8,13-15,18-19H,9-12H2,1-2H3,(H,23,24,25)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393943
PNG
(US9969749, Example 1-36 | trans-N,N-dimethyl-N'- {...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnccc1C(F)(F)F
Show InChI InChI=1S/C22H24F3N5/c1-30(2)16-6-4-15(5-7-16)29-21-17-11-14(3-8-20(17)27-13-28-21)18-12-26-10-9-19(18)22(23,24)25/h3,8-13,15-16H,4-7H2,1-2H3,(H,27,28,29)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393953
PNG
(N-[trans-4-(morpholin- 4-yl)cyclohexyl]-6- (pyridi...)
Show SMILES C1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cccnc1
Show InChI InChI=1S/C23H27N5O/c1-2-18(15-24-9-1)17-3-8-22-21(14-17)23(26-16-25-22)27-19-4-6-20(7-5-19)28-10-12-29-13-11-28/h1-3,8-9,14-16,19-20H,4-7,10-13H2,(H,25,26,27)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393936
PNG
(US9969749, Example 1-29 | trans-N'-[6-(2- aminopyr...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(N)nc1
Show InChI InChI=1S/C20H25N7/c1-27(2)16-6-4-15(5-7-16)26-19-17-9-13(3-8-18(17)24-12-25-19)14-10-22-20(21)23-11-14/h3,8-12,15-16H,4-7H2,1-2H3,(H2,21,22,23)(H,24,25,26)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394041
PNG
(6-(6-fluoro-5- methoxypyridin-3-yl)-N- [trans-4-(m...)
Show SMILES COc1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H28FN5O2/c1-31-22-13-17(14-26-23(22)25)16-2-7-21-20(12-16)24(28-15-27-21)29-18-3-5-19(6-4-18)30-8-10-32-11-9-30/h2,7,12-15,18-19H,3-6,8-11H2,1H3,(H,27,28,29)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394001
PNG
(N-[trans-4-(morpholin- 4-yl)cyclohexyl]-6-(1H- pyr...)
Show SMILES N\C=C/C(=N)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C21H28N6O/c22-8-7-19(23)15-1-6-20-18(13-15)21(25-14-24-20)26-16-2-4-17(5-3-16)27-9-11-28-12-10-27/h1,6-8,13-14,16-17,23H,2-5,9-12,22H2,(H,24,25,26)/b8-7-,23-19?/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393967
PNG
(US9969749, Example 1-58 | trans-N,N-dimethyl-N'- [...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(N)c(C=N)c1
Show InChI InChI=1S/C22H27N7/c1-29(2)18-6-4-17(5-7-18)28-22-19-10-14(3-8-20(19)26-13-27-22)16-9-15(11-23)21(24)25-12-16/h3,8-13,17-18,23H,4-7H2,1-2H3,(H2,24,25)(H,26,27,28)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394010
PNG
(5-(4-{[trans-4- (morpholin-4- yl)cyclohexyl]amino}...)
Show SMILES N#Cc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H26N6O/c25-13-17-11-19(15-26-14-17)18-1-6-23-22(12-18)24(28-16-27-23)29-20-2-4-21(5-3-20)30-7-9-31-10-8-30/h1,6,11-12,14-16,20-21H,2-5,7-10H2,(H,27,28,29)/t20-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394032
PNG
(6-(3-methyl-1H-pyrazol- 4-yl)-N-[trans-4- (morphol...)
Show SMILES Cc1n[nH]cc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1/C22H28N6O/c1-15-20(13-25-27-15)16-2-7-21-19(12-16)22(24-14-23-21)26-17-3-5-18(6-4-17)28-8-10-29-11-9-28/h2,7,12-14,17-18H,3-6,8-11H2,1H3,(H,25,27)(H,23,24,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394009
PNG
(6-(5-fluoropyridin-3-yl)- N-[trans-4-(morpholin- 4...)
Show SMILES Fc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H26FN5O/c24-18-11-17(13-25-14-18)16-1-6-22-21(12-16)23(27-15-26-22)28-19-2-4-20(5-3-19)29-7-9-30-10-8-29/h1,6,11-15,19-20H,2-5,7-10H2,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393995
PNG
(7-fluoro-6-[5- (methylamino)pyridin- 3-yl]-N-(tran...)
Show SMILES CNc1cncc(c1)-c1cc2c(N[C@H]3CC[C@@H](CC3)N3CCOCC3)ncnc2cc1F
Show InChI InChI=1S/C24H29FN6O/c1-26-18-10-16(13-27-14-18)20-11-21-23(12-22(20)25)28-15-29-24(21)30-17-2-4-19(5-3-17)31-6-8-32-9-7-31/h10-15,17,19,26H,2-9H2,1H3,(H,28,29,30)/t17-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393971
PNG
(US9969749, Example 1-62 | trans-N'-[6-3,5- difluor...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cc(F)cc(F)c1
Show InChI InChI=1S/C22H24F2N4/c1-28(2)19-6-4-18(5-7-19)27-22-20-11-14(3-8-21(20)25-13-26-22)15-9-16(23)12-17(24)10-15/h3,8-13,18-19H,4-7H2,1-2H3,(H,25,26,27)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394002
PNG
(N-[5-(4-{[trans-4- (morpholin-4- yl)cyclohexyl]ami...)
Show SMILES CSNc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H30N6OS/c1-32-29-20-12-18(14-25-15-20)17-2-7-23-22(13-17)24(27-16-26-23)28-19-3-5-21(6-4-19)30-8-10-31-11-9-30/h2,7,12-16,19,21,29H,3-6,8-11H2,1H3,(H,26,27,28)/t19-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393960
PNG
(US9969749, Example 1-53 | trans-N'-[6-(5- fluoropy...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(F)c1
Show InChI InChI=1S/C21H24FN5/c1-27(2)18-6-4-17(5-7-18)26-21-19-10-14(3-8-20(19)24-13-25-21)15-9-16(22)12-23-11-15/h3,8-13,17-18H,4-7H2,1-2H3,(H,24,25,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393950
PNG
(2-{[5-(4-{[trans-4- (dimethylamino)cyclohexyl] ami...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc(NCCO)nc1
Show InChI InChI=1S/C22H29N7O/c1-29(2)18-6-4-17(5-7-18)28-21-19-11-15(3-8-20(19)26-14-27-21)16-12-24-22(25-13-16)23-9-10-30/h3,8,11-14,17-18,30H,4-7,9-10H2,1-2H3,(H,23,24,25)(H,26,27,28)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393977
PNG
(6-(3,5-difluorophenyl)- N-(trans-4-morpholin-4- yl...)
Show SMILES Fc1cc(F)cc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H26F2N4O/c25-18-11-17(12-19(26)14-18)16-1-6-23-22(13-16)24(28-15-27-23)29-20-2-4-21(5-3-20)30-7-9-31-10-8-30/h1,6,11-15,20-21H,2-5,7-10H2,(H,27,28,29)/t20-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393958
PNG
(US9969749, Example 1-51 | trans-N'-[6-(5- methoxyp...)
Show SMILES COc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C22H27N5O/c1-27(2)18-7-5-17(6-8-18)26-22-20-11-15(4-9-21(20)24-14-25-22)16-10-19(28-3)13-23-12-16/h4,9-14,17-18H,5-8H2,1-3H3,(H,24,25,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393914
PNG
(US9969749, Example 1-8 | trans-N'-[6-(2- methoxypy...)
Show SMILES COc1cc(ccn1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C22H27N5O/c1-27(2)18-7-5-17(6-8-18)26-22-19-12-15(4-9-20(19)24-14-25-22)16-10-11-23-21(13-16)28-3/h4,9-14,17-18H,5-8H2,1-3H3,(H,24,25,26)/t17-,18-
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Merck Sharp & Dohme Corp.

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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394004
PNG
(6-(5-methylpyridin-3- yl)-N-[trans-4- (morpholin-4...)
Show SMILES Cc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H29N5O/c1-17-12-19(15-25-14-17)18-2-7-23-22(13-18)24(27-16-26-23)28-20-3-5-21(6-4-20)29-8-10-30-11-9-29/h2,7,12-16,20-21H,3-6,8-11H2,1H3,(H,26,27,28)/t20-,21-
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Merck Sharp & Dohme Corp.

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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393907
PNG
(US9969749, Example 1-1)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnnc(C)c1
Show InChI InChI=1S/C21H26N6/c1-14-10-16(12-24-26-14)15-4-9-20-19(11-15)21(23-13-22-20)25-17-5-7-18(8-6-17)27(2)3/h4,9-13,17-18H,5-8H2,1-3H3,(H,22,23,25)/t17-,18-
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Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394045
PNG
(6-(6-chloro-5- fluoropyridin-3-yl)-N- [trans-4-(mo...)
Show SMILES Fc1cc(cnc1Cl)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H25ClFN5O/c24-22-20(25)12-16(13-26-22)15-1-6-21-19(11-15)23(28-14-27-21)29-17-2-4-18(5-3-17)30-7-9-31-10-8-30/h1,6,11-14,17-18H,2-5,7-10H2,(H,27,28,29)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393919
PNG
(US9969749, Example 1-13 | trans-N,N-dimethyl-N'- {...)
Show SMILES CNc1ncc(cn1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C21H27N7/c1-22-21-23-11-15(12-24-21)14-4-9-19-18(10-14)20(26-13-25-19)27-16-5-7-17(8-6-16)28(2)3/h4,9-13,16-17H,5-8H2,1-3H3,(H,22,23,24)(H,25,26,27)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394050
PNG
(US9969749, Example 4-1)
Show SMILES CN(C)C(=O)c1cccc(n1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C26H32N6O2/c1-31(2)26(33)24-5-3-4-22(30-24)18-6-11-23-21(16-18)25(28-17-27-23)29-19-7-9-20(10-8-19)32-12-14-34-15-13-32/h3-6,11,16-17,19-20H,7-10,12-15H2,1-2H3,(H,27,28,29)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393951
PNG
(3-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cccc(c1)C#N
Show InChI InChI=1S/C23H25N5/c1-28(2)20-9-7-19(8-10-20)27-23-21-13-18(6-11-22(21)25-15-26-23)17-5-3-4-16(12-17)14-24/h3-6,11-13,15,19-20H,7-10H2,1-2H3,(H,25,26,27)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393917
PNG
(US9969749, Example 1-11 | cis or trans-N'-[6-(6- a...)
Show SMILES CN(C)C1CCC(CC1)Nc1ncnc2ccc(cc12)-c1ccc(N)nc1
Show InChI InChI=1S/C21H26N6/c1-27(2)17-7-5-16(6-8-17)26-21-18-11-14(3-9-19(18)24-13-25-21)15-4-10-20(22)23-12-15/h3-4,9-13,16-17H,5-8H2,1-2H3,(H2,22,23)(H,24,25,26)
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394047
PNG
(6-[5- (difluoromethyl)pyridin- 3-yl]-N-[trans-4- (...)
Show SMILES FC(F)c1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H27F2N5O/c25-23(26)18-11-17(13-27-14-18)16-1-6-22-21(12-16)24(29-15-28-22)30-19-2-4-20(5-3-19)31-7-9-32-10-8-31/h1,6,11-15,19-20,23H,2-5,7-10H2,(H,28,29,30)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393988
PNG
(5-{5-methyl-4-[(trans-4- morpholin-4- ylcyclohexyl...)
Show SMILES Cc1c(ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c12)-c1cncc(O)c1
Show InChI InChI=1S/C24H29N5O2/c1-16-21(17-12-20(30)14-25-13-17)6-7-22-23(16)24(27-15-26-22)28-18-2-4-19(5-3-18)29-8-10-31-11-9-29/h6-7,12-15,18-19,30H,2-5,8-11H2,1H3,(H,26,27,28)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393984
PNG
(6-(1-methyl-1H- pyrazol-4-yl)-N-(trans- 4-morpholi...)
Show SMILES Cn1cc(cn1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C22H28N6O/c1-27-14-17(13-25-27)16-2-7-21-20(12-16)22(24-15-23-21)26-18-3-5-19(6-4-18)28-8-10-29-11-9-28/h2,7,12-15,18-19H,3-6,8-11H2,1H3,(H,23,24,26)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394029
PNG
(3-(4-{[trans-4- (morpholin-4- yl)cyclohexyl]amino}...)
Show SMILES N#Cc1sccc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H25N5OS/c24-14-22-19(7-12-30-22)16-1-6-21-20(13-16)23(26-15-25-21)27-17-2-4-18(5-3-17)28-8-10-29-11-9-28/h1,6-7,12-13,15,17-18H,2-5,8-11H2,(H,25,26,27)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393937
PNG
(US9969749, Example 1-30 | trans-N,N-dimethyl-N'- [...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1ccc(C)nc1
Show InChI InChI=1S/C22H27N5/c1-15-4-5-17(13-23-15)16-6-11-21-20(12-16)22(25-14-24-21)26-18-7-9-19(10-8-18)27(2)3/h4-6,11-14,18-19H,7-10H2,1-3H3,(H,24,25,26)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393946
PNG
(3-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cccnc1C#N
Show InChI InChI=1S/C22H24N6/c1-28(2)17-8-6-16(7-9-17)27-22-19-12-15(5-10-20(19)25-14-26-22)18-4-3-11-24-21(18)13-23/h3-5,10-12,14,16-17H,6-9H2,1-2H3,(H,25,26,27)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393934
PNG
(5-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1ccc(nc1)C#N
Show InChI InChI=1S/C22H24N6/c1-28(2)19-8-6-17(7-9-19)27-22-20-11-15(4-10-21(20)25-14-26-22)16-3-5-18(12-23)24-13-16/h3-5,10-11,13-14,17,19H,6-9H2,1-2H3,(H,25,26,27)/t17-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393938
PNG
(US9969749, Example 1-31 | methyl 5-(4-{[trans-4- (...)
Show SMILES COC(=O)c1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C23H27N5O2/c1-28(2)19-7-5-18(6-8-19)27-22-20-11-15(4-9-21(20)25-14-26-22)16-10-17(13-24-12-16)23(29)30-3/h4,9-14,18-19H,5-8H2,1-3H3,(H,25,26,27)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393964
PNG
(US9969749, Example 1-55 | trans-N,N-dimethyl-N'- [...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc2[nH]ccc2c1
Show InChI InChI=1/C23H26N6/c1-29(2)19-6-4-18(5-7-19)28-23-20-12-15(3-8-21(20)26-14-27-23)17-11-16-9-10-24-22(16)25-13-17/h3,8-14,18-19H,4-7H2,1-2H3,(H,24,25)(H,26,27,28)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393963
PNG
(5-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(c1)C#N
Show InChI InChI=1S/C22H24N6/c1-28(2)19-6-4-18(5-7-19)27-22-20-10-16(3-8-21(20)25-14-26-22)17-9-15(11-23)12-24-13-17/h3,8-10,12-14,18-19H,4-7H2,1-2H3,(H,25,26,27)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394028
PNG
(6-(2,3-dihydro-1H- pyrrolo[3,2-b]pyridin-6- yl)-N-...)
Show SMILES C1Cc2ncc(cc2N1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C25H30N6O/c1-6-22-21(13-17(1)18-14-24-23(27-15-18)7-8-26-24)25(29-16-28-22)30-19-2-4-20(5-3-19)31-9-11-32-12-10-31/h1,6,13-16,19-20,26H,2-5,7-12H2,(H,28,29,30)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394030
PNG
(4-(4-{[trans-4- (morpholin-4- yl)cyclohexyl]amino}...)
Show SMILES N#Cc1cscc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H25N5OS/c24-12-17-13-30-14-21(17)16-1-6-22-20(11-16)23(26-15-25-22)27-18-2-4-19(5-3-18)28-7-9-29-10-8-28/h1,6,11,13-15,18-19H,2-5,7-10H2,(H,25,26,27)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393928
PNG
(3-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnccc1C#N
Show InChI InChI=1S/C22H24N6/c1-28(2)18-6-4-17(5-7-18)27-22-19-11-15(3-8-21(19)25-14-26-22)20-13-24-10-9-16(20)12-23/h3,8-11,13-14,17-18H,4-7H2,1-2H3,(H,25,26,27)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394023
PNG
(5-{4-[(trans-4- morpholin-4- ylcyclohexyl)amino] q...)
Show SMILES N#CC1=C(NNN1)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C21H26N8O/c22-12-19-20(27-28-26-19)14-1-6-18-17(11-14)21(24-13-23-18)25-15-2-4-16(5-3-15)29-7-9-30-10-8-29/h1,6,11,13,15-16,26-28H,2-5,7-10H2,(H,23,24,25)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393945
PNG
(US9969749, Example 1-38 | trans-N'-[6-(3- methoxyp...)
Show SMILES COc1cnccc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C22H27N5O/c1-27(2)17-7-5-16(6-8-17)26-22-19-12-15(4-9-20(19)24-14-25-22)18-10-11-23-13-21(18)28-3/h4,9-14,16-17H,5-8H2,1-3H3,(H,24,25,26)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394043
PNG
(6-[5-(dimethylamino)-6- fluoropyridin-3-yl]-N- [tr...)
Show SMILES CN(C)c1cc(cnc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C25H31FN6O/c1-31(2)23-14-18(15-27-24(23)26)17-3-8-22-21(13-17)25(29-16-28-22)30-19-4-6-20(7-5-19)32-9-11-33-12-10-32/h3,8,13-16,19-20H,4-7,9-12H2,1-2H3,(H,28,29,30)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394026
PNG
(N-(trans-4-morpholin-4- ylcyclohexyl)-6-[3- (trifl...)
Show SMILES FC(F)(F)c1n[nH]cc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1/C22H25F3N6O/c23-22(24,25)20-18(12-28-30-20)14-1-6-19-17(11-14)21(27-13-26-19)29-15-2-4-16(5-3-15)31-7-9-32-10-8-31/h1,6,11-13,15-16H,2-5,7-10H2,(H,28,30)(H,26,27,29)/t15-,16-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393952
PNG
(US9969749, Example 1-45 | trans-N'-[6-(1H-indol-5-...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1ccc2[nH]ccc2c1
Show InChI InChI=1/C24H27N5/c1-29(2)20-7-5-19(6-8-20)28-24-21-14-17(4-10-23(21)26-15-27-24)16-3-9-22-18(13-16)11-12-25-22/h3-4,9-15,19-20,25H,5-8H2,1-2H3,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393947
PNG
(US9969749, Example 1-40 | trans-N'-{6-[5-(2- metho...)
Show SMILES COCCOc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C24H31N5O2/c1-29(2)20-7-5-19(6-8-20)28-24-22-13-17(4-9-23(22)26-16-27-24)18-12-21(15-25-14-18)31-11-10-30-3/h4,9,12-16,19-20H,5-8,10-11H2,1-3H3,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393926
PNG
(4-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1ccncc1C#N
Show InChI InChI=1S/C22H24N6/c1-28(2)18-6-4-17(5-7-18)27-22-20-11-15(3-8-21(20)25-14-26-22)19-9-10-24-13-16(19)12-23/h3,8-11,13-14,17-18H,4-7H2,1-2H3,(H,25,26,27)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394037
PNG
(6-(2-methyl-1H- imidazol-4-yl)-N-[trans- 4-(morpho...)
Show SMILES Cc1nc(c[nH]1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1/C22H28N6O/c1-15-23-13-21(26-15)16-2-7-20-19(12-16)22(25-14-24-20)27-17-3-5-18(6-4-17)28-8-10-29-11-9-28/h2,7,12-14,17-18H,3-6,8-11H2,1H3,(H,23,26)(H,24,25,27)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393924
PNG
(US9969749, Example 1-18 | trans-N'-[6-(1-ethyl-1H-...)
Show SMILES CCN\C=C(/C=N)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C21H30N6/c1-4-23-13-16(12-22)15-5-10-20-19(11-15)21(25-14-24-20)26-17-6-8-18(9-7-17)27(2)3/h5,10-14,17-18,22-23H,4,6-9H2,1-3H3,(H,24,25,26)/b16-13+,22-12?/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394014
PNG
(6-(2-methyl-1,3-thiazol- 4-yl)-N-(trans-4- morphol...)
Show SMILES Cc1nc(cs1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C22H27N5OS/c1-15-25-21(13-29-15)16-2-7-20-19(12-16)22(24-14-23-20)26-17-3-5-18(6-4-17)27-8-10-28-11-9-27/h2,7,12-14,17-18H,3-6,8-11H2,1H3,(H,23,24,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393997
PNG
(6-(1H-indol-4-yl)-N- [trans-4-(morpholin-4- yl)cyc...)
Show SMILES C1CN(CCO1)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cccc2[nH]ccc12
Show InChI InChI=1/C26H29N5O/c1-2-21(22-10-11-27-24(22)3-1)18-4-9-25-23(16-18)26(29-17-28-25)30-19-5-7-20(8-6-19)31-12-14-32-15-13-31/h1-4,9-11,16-17,19-20,27H,5-8,12-15H2,(H,28,29,30)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394036
PNG
(6-(3,5-dimethyl-1H- pyrazol-4-yl)-N-[trans- 4-(mor...)
Show SMILES Cc1n[nH]c(C)c1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1/C23H30N6O/c1-15-22(16(2)28-27-15)17-3-8-21-20(13-17)23(25-14-24-21)26-18-4-6-19(7-5-18)29-9-11-30-12-10-29/h3,8,13-14,18-19H,4-7,9-12H2,1-2H3,(H,27,28)(H,24,25,26)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393970
PNG
(US9969749, Example 1-61 | trans-N'-[6-(furo[3,2- b...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc2ccoc2c1
Show InChI InChI=1S/C23H25N5O/c1-28(2)18-6-4-17(5-7-18)27-23-19-11-15(3-8-20(19)25-14-26-23)16-12-22-21(24-13-16)9-10-29-22/h3,8-14,17-18H,4-7H2,1-2H3,(H,25,26,27)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394016
PNG
(N-(trans-4-morpholin-4- ylcyclohexyl)-6-[5- (trifl...)
Show SMILES FC(F)(F)c1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H26F3N5O/c25-24(26,27)18-11-17(13-28-14-18)16-1-6-22-21(12-16)23(30-15-29-22)31-19-2-4-20(5-3-19)32-7-9-33-10-8-32/h1,6,11-15,19-20H,2-5,7-10H2,(H,29,30,31)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394020
PNG
(6-{4-[(trans-4- morpholin-4- ylcyclohexyl)amino] q...)
Show SMILES OC(=O)c1cccc(n1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H27N5O3/c30-24(31)22-3-1-2-20(28-22)16-4-9-21-19(14-16)23(26-15-25-21)27-17-5-7-18(8-6-17)29-10-12-32-13-11-29/h1-4,9,14-15,17-18H,5-8,10-13H2,(H,30,31)(H,25,26,27)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393968
PNG
(US9969749, Example 1-59 | trans-N,N-dimethyl-N'- [...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc2cc[nH]c2c1
Show InChI InChI=1/C23H26N6/c1-29(2)18-6-4-17(5-7-18)28-23-19-11-15(3-8-20(19)26-14-27-23)16-12-22-21(25-13-16)9-10-24-22/h3,8-14,17-18,24H,4-7H2,1-2H3,(H,26,27,28)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394033
PNG
(6-(1,5-dimethyl-1H- pyrazol-4-yl)-N-[trans- 4-(mor...)
Show SMILES Cc1c(cnn1C)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H30N6O/c1-16-21(14-26-28(16)2)17-3-8-22-20(13-17)23(25-15-24-22)27-18-4-6-19(7-5-18)29-9-11-30-12-10-29/h3,8,13-15,18-19H,4-7,9-12H2,1-2H3,(H,24,25,27)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393965
PNG
(N-tert-butyl-5-(4- {[trans-4- (dimethylamino)cyclo...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(c1)C(=O)NC(C)(C)C
Show InChI InChI=1S/C26H34N6O/c1-26(2,3)31-25(33)19-12-18(14-27-15-19)17-6-11-23-22(13-17)24(29-16-28-23)30-20-7-9-21(10-8-20)32(4)5/h6,11-16,20-21H,7-10H2,1-5H3,(H,31,33)(H,28,29,30)/t20-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394027
PNG
(6-(1-methyl-1H-1,2,3- triazol-5-yl)-N-(trans-4- mo...)
Show SMILES CN1NNC=C1c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C21H29N7O/c1-27-20(13-24-26-27)15-2-7-19-18(12-15)21(23-14-22-19)25-16-3-5-17(6-4-16)28-8-10-29-11-9-28/h2,7,12-14,16-17,24,26H,3-6,8-11H2,1H3,(H,22,23,25)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393927
PNG
(US9969749, Example 1-21 | trans-N,N-dimethyl-N'- [...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1ccncc1C
Show InChI InChI=1S/C22H27N5/c1-15-13-23-11-10-19(15)16-4-9-21-20(12-16)22(25-14-24-21)26-17-5-7-18(8-6-17)27(2)3/h4,9-14,17-18H,5-8H2,1-3H3,(H,24,25,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394039
PNG
(6-(1-methyl-1H-1,2,4- triazol-5-yl)-N-[trans-4- (m...)
Show SMILES Cn1ncnc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C21H27N7O/c1-27-21(24-14-25-27)15-2-7-19-18(12-15)20(23-13-22-19)26-16-3-5-17(6-4-16)28-8-10-29-11-9-28/h2,7,12-14,16-17H,3-6,8-11H2,1H3,(H,22,23,26)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393956
PNG
(US9969749, Example 1-49 | trans-N'-[6-(2,3- dihydr...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1ccc2OCCOc2c1
Show InChI InChI=1S/C24H28N4O2/c1-28(2)19-7-5-18(6-8-19)27-24-20-13-16(3-9-21(20)25-15-26-24)17-4-10-22-23(14-17)30-12-11-29-22/h3-4,9-10,13-15,18-19H,5-8,11-12H2,1-2H3,(H,25,26,27)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394000
PNG
(N-[cis-4-(morpholin-4- yl)cyclohexyl]-6-[2- (trifl...)
Show SMILES FC(F)(F)c1ncc(cn1)-c1ccc2ncnc(N[C@H]3CC[C@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H25F3N6O/c24-23(25,26)22-27-12-16(13-28-22)15-1-6-20-19(11-15)21(30-14-29-20)31-17-2-4-18(5-3-17)32-7-9-33-10-8-32/h1,6,11-14,17-18H,2-5,7-10H2,(H,29,30,31)/t17-,18+
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394031
PNG
(6-(4-methyl-1H- imidazol-5-yl)-N-[trans- 4-(morpho...)
Show SMILES Cc1nc[nH]c1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1/C22H28N6O/c1-15-21(25-13-23-15)16-2-7-20-19(12-16)22(26-14-24-20)27-17-3-5-18(6-4-17)28-8-10-29-11-9-28/h2,7,12-14,17-18H,3-6,8-11H2,1H3,(H,23,25)(H,24,26,27)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393959
PNG
(US9969749, Example 1-52 | trans-N'-[6-(5-fluoro-6-...)
Show SMILES COc1ncc(cc1F)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C22H26FN5O/c1-28(2)17-7-5-16(6-8-17)27-21-18-10-14(4-9-20(18)25-13-26-21)15-11-19(23)22(29-3)24-12-15/h4,9-13,16-17H,5-8H2,1-3H3,(H,25,26,27)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393922
PNG
(US9969749, Example 1-16 | trans-N,N-dimethyl-N'- {...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C(\C=N)=C\NC1CCCCO1
Show InChI InChI=1S/C24H34N6O/c1-30(2)20-9-7-19(8-10-20)29-24-21-13-17(6-11-22(21)27-16-28-24)18(14-25)15-26-23-5-3-4-12-31-23/h6,11,13-16,19-20,23,25-26H,3-5,7-10,12H2,1-2H3,(H,27,28,29)/b18-15+,25-14?/t19-,20-,23?
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393985
PNG
(5-methyl-N-(trans-4- morpholin-4- ylcyclohexyl)-6-...)
Show SMILES Cc1c(ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c12)-c1cncnc1
Show InChI InChI=1S/C23H28N6O/c1-16-20(17-12-24-14-25-13-17)6-7-21-22(16)23(27-15-26-21)28-18-2-4-19(5-3-18)29-8-10-30-11-9-29/h6-7,12-15,18-19H,2-5,8-11H2,1H3,(H,26,27,28)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394024
PNG
((1-methyl-4-{4-[(trans- 4-morpholin-4- ylcyclohexy...)
Show SMILES Cn1cc(c(CO)n1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H30N6O2/c1-28-13-20(22(14-30)27-28)16-2-7-21-19(12-16)23(25-15-24-21)26-17-3-5-18(6-4-17)29-8-10-31-11-9-29/h2,7,12-13,15,17-18,30H,3-6,8-11,14H2,1H3,(H,24,25,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394025
PNG
(6-(1-methyl-1H-pyrazol- 5-yl)-N-(trans-4- morpholi...)
Show SMILES Cn1nccc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C22H28N6O/c1-27-21(8-9-25-27)16-2-7-20-19(14-16)22(24-15-23-20)26-17-3-5-18(6-4-17)28-10-12-29-13-11-28/h2,7-9,14-15,17-18H,3-6,10-13H2,1H3,(H,23,24,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394006
PNG
(2-[5-(4-{[trans-4- (morpholin-4- yl)cyclohexyl]ami...)
Show SMILES CC(C)(O)c1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C26H33N5O2/c1-26(2,32)20-13-19(15-27-16-20)18-3-8-24-23(14-18)25(29-17-28-24)30-21-4-6-22(7-5-21)31-9-11-33-12-10-31/h3,8,13-17,21-22,32H,4-7,9-12H2,1-2H3,(H,28,29,30)/t21-,22-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393931
PNG
(US9969749, Example 1-24 | trans-N'-[6-(3,5- dimeth...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C(=C(/C)O)\C(C)=N
Show InChI InChI=1S/C21H29N5O/c1-13(22)20(14(2)27)15-5-10-19-18(11-15)21(24-12-23-19)25-16-6-8-17(9-7-16)26(3)4/h5,10-12,16-17,22,27H,6-9H2,1-4H3,(H,23,24,25)/b20-14+,22-13?/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393925
PNG
(US9969749, Example 1-19 | trans-N,N-dimethyl-N'- {...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C(\C=N)=C\NCc1ccncc1
Show InChI InChI=1S/C25H31N7/c1-32(2)22-6-4-21(5-7-22)31-25-23-13-19(3-8-24(23)29-17-30-25)20(14-26)16-28-15-18-9-11-27-12-10-18/h3,8-14,16-17,21-22,26,28H,4-7,15H2,1-2H3,(H,29,30,31)/b20-16+,26-14?/t21-,22-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393923
PNG
(US9969749, Example 1-17 | trans-N,N-dimethyl-N'- {...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C(\C=N)=C\NCc1ccccn1
Show InChI InChI=1S/C25H31N7/c1-32(2)22-9-7-20(8-10-22)31-25-23-13-18(6-11-24(23)29-17-30-25)19(14-26)15-27-16-21-5-3-4-12-28-21/h3-6,11-15,17,20,22,26-27H,7-10,16H2,1-2H3,(H,29,30,31)/b19-15+,26-14?/t20-,22-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394015
PNG
(6-[2-(1-methylethyl)- 1,3-thiazol-4-yl]-N- (trans-...)
Show SMILES CC(C)c1nc(cs1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C24H31N5OS/c1-16(2)24-28-22(14-31-24)17-3-8-21-20(13-17)23(26-15-25-21)27-18-4-6-19(7-5-18)29-9-11-30-12-10-29/h3,8,13-16,18-19H,4-7,9-12H2,1-2H3,(H,25,26,27)/t18-,19-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393942
PNG
(US9969749, Example 1-35 | trans-N'-[6-(4- methoxyp...)
Show SMILES COc1ccncc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C22H27N5O/c1-27(2)17-7-5-16(6-8-17)26-22-18-12-15(4-9-20(18)24-14-25-22)19-13-23-11-10-21(19)28-3/h4,9-14,16-17H,5-8H2,1-3H3,(H,24,25,26)/t16-,17-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393987
PNG
(5-methyl-N-(trans-4- morpholin-4- ylcyclohexyl)-6-...)
Show SMILES Cc1c(ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c12)-c1ccncc1
Show InChI InChI=1S/C24H29N5O/c1-17-21(18-8-10-25-11-9-18)6-7-22-23(17)24(27-16-26-22)28-19-2-4-20(5-3-19)29-12-14-30-15-13-29/h6-11,16,19-20H,2-5,12-15H2,1H3,(H,26,27,28)/t19-,20-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394034
PNG
(6-(4-methyl-1H- imidazol-2-yl)-N-[trans- 4-(morpho...)
Show SMILES Cc1c[nH]c(n1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1/C22H28N6O/c1-15-13-23-21(26-15)16-2-7-20-19(12-16)22(25-14-24-20)27-17-3-5-18(6-4-17)28-8-10-29-11-9-28/h2,7,12-14,17-18H,3-6,8-11H2,1H3,(H,23,26)(H,24,25,27)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393929
PNG
(US9969749, Example 1-23 | trans-N,N-dimethyl-N'- {...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(c1)N1CCOCC1
Show InChI InChI=1S/C25H32N6O/c1-30(2)21-6-4-20(5-7-21)29-25-23-14-18(3-8-24(23)27-17-28-25)19-13-22(16-26-15-19)31-9-11-32-12-10-31/h3,8,13-17,20-21H,4-7,9-12H2,1-2H3,(H,27,28,29)/t20-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393944
PNG
(5-(4-{[trans-4- (dimethylamino)cyclohexyl] amino}q...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cncc(c1)C(O)=O
Show InChI InChI=1S/C22H25N5O2/c1-27(2)18-6-4-17(5-7-18)26-21-19-10-14(3-8-20(19)24-13-25-21)15-9-16(22(28)29)12-23-11-15/h3,8-13,17-18H,4-7H2,1-2H3,(H,28,29)(H,24,25,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394038
PNG
(6-(1-methyl-1H- imidazol-2-yl)-N-[trans- 4-(morpho...)
Show SMILES Cn1ccnc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C22H28N6O/c1-27-9-8-23-22(27)16-2-7-20-19(14-16)21(25-15-24-20)26-17-3-5-18(6-4-17)28-10-12-29-13-11-28/h2,7-9,14-15,17-18H,3-6,10-13H2,1H3,(H,24,25,26)/t17-,18-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393933
PNG
(US9969749, Example 1-26 | trans-N,N-dimethyl-N'- [...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C(=C(/C)O)\C(=N)c1ccccc1
Show InChI InChI=1S/C26H31N5O/c1-17(32)24(25(27)18-7-5-4-6-8-18)19-9-14-23-22(15-19)26(29-16-28-23)30-20-10-12-21(13-11-20)31(2)3/h4-9,14-16,20-21,27,32H,10-13H2,1-3H3,(H,28,29,30)/b24-17-,27-25?/t20-,21-
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Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394017
PNG
(3-{4-[(trans-4- morpholin-4- ylcyclohexyl)amino] q...)
Show SMILES Oc1ncc(cc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1)C(F)(F)F
Show InChI InChI=1S/C24H26F3N5O2/c25-24(26,27)16-12-19(23(33)28-13-16)15-1-6-21-20(11-15)22(30-14-29-21)31-17-2-4-18(5-3-17)32-7-9-34-10-8-32/h1,6,11-14,17-18H,2-5,7-10H2,(H,28,33)(H,29,30,31)/t17-,18-
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UniChem
US Patent
n/an/a 928n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394035
PNG
(6-(1,4-dimethyl-1H- imidazol-2-yl)-N-[trans- 4-(mo...)
Show SMILES Cc1cn(C)c(n1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C23H30N6O/c1-16-14-28(2)23(26-16)17-3-8-21-20(13-17)22(25-15-24-21)27-18-4-6-19(7-5-18)29-9-11-30-12-10-29/h3,8,13-15,18-19H,4-7,9-12H2,1-2H3,(H,24,25,27)/t18-,19-
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n/an/a 1.19E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393986
PNG
(5-methyl-6-(1-methyl- 1H-pyrazol-4-yl)-N- (trans-4...)
Show SMILES CN\C=C(/C=N)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1C
Show InChI InChI=1S/C23H32N6O/c1-16-20(17(13-24)14-25-2)7-8-21-22(16)23(27-15-26-21)28-18-3-5-19(6-4-18)29-9-11-30-12-10-29/h7-8,13-15,18-19,24-25H,3-6,9-12H2,1-2H3,(H,26,27,28)/b17-14+,24-13?/t18-,19-
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n/an/a 1.31E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393921
PNG
(US9969749, Example 1-15 | trans-N,N-dimethyl-N'- (...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)C(\C=N)=C\NCCN1CCOCC1
Show InChI InChI=1S/C25H37N7O/c1-31(2)22-6-4-21(5-7-22)30-25-23-15-19(3-8-24(23)28-18-29-25)20(16-26)17-27-9-10-32-11-13-33-14-12-32/h3,8,15-18,21-22,26-27H,4-7,9-14H2,1-2H3,(H,28,29,30)/b20-17+,26-16?/t21-,22-
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n/an/a 1.33E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393920
PNG
(US9969749, Example 1-14 | trans-N'-{6-[1-(1- ethox...)
Show SMILES CCOC(C)N\C=C(/C=N)c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C23H34N6O/c1-5-30-16(2)25-14-18(13-24)17-6-11-22-21(12-17)23(27-15-26-22)28-19-7-9-20(10-8-19)29(3)4/h6,11-16,19-20,24-25H,5,7-10H2,1-4H3,(H,26,27,28)/b18-14+,24-13?/t16?,19-,20-
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n/an/a 1.36E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393910
PNG
(US9969749, Example 1-4 | US9969749, Example 1-7 | ...)
Show SMILES CN(C)C1CCC(CC1)Nc1ncnc2ccc(cc12)-c1cccnc1
Show InChI InChI=1S/C21H25N5/c1-26(2)18-8-6-17(7-9-18)25-21-19-12-15(16-4-3-11-22-13-16)5-10-20(19)23-14-24-21/h3-5,10-14,17-18H,6-9H2,1-2H3,(H,23,24,25)
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n/an/a 1.61E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393969
PNG
(US9969749, Example 1-60 | trans-N,N-dimethyl-N'- [...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc2n(C)cnc2c1
Show InChI InChI=1S/C23H27N7/c1-29(2)18-7-5-17(6-8-18)28-22-19-10-15(4-9-20(19)25-13-26-22)16-11-21-23(24-12-16)30(3)14-27-21/h4,9-14,17-18H,5-8H2,1-3H3,(H,25,26,28)/t17-,18-
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n/an/a 1.69E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393909
PNG
(US9969749, Example 1-3 | US9969749, Example 1-6 | ...)
Show SMILES CN(C)C1CCC(CC1)Nc1ncnc2ccc(cc12)-c1ccncc1
Show InChI InChI=1S/C21H25N5/c1-26(2)18-6-4-17(5-7-18)25-21-19-13-16(15-9-11-22-12-10-15)3-8-20(19)23-14-24-21/h3,8-14,17-18H,4-7H2,1-2H3,(H,23,24,25)
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n/an/a 2.29E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393948
PNG
(US9969749, Example 1-41 | trans-N,N-dimethyl-N'- {...)
Show SMILES CSc1cncc(c1)-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N(C)C)c2c1
Show InChI InChI=1S/C22H27N5S/c1-27(2)18-7-5-17(6-8-18)26-22-20-11-15(4-9-21(20)24-14-25-22)16-10-19(28-3)13-23-12-16/h4,9-14,17-18H,5-8H2,1-3H3,(H,24,25,26)/t17-,18-
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n/an/a 2.35E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393908
PNG
(US9969749, Example 1-2 | US9969749, Example 1-5 | ...)
Show SMILES CN(C)C1CCC(CC1)Nc1ncnc2ccc(cc12)-c1ccccc1
Show InChI InChI=1S/C22H26N4/c1-26(2)19-11-9-18(10-12-19)25-22-20-14-17(16-6-4-3-5-7-16)8-13-21(20)23-15-24-22/h3-8,13-15,18-19H,9-12H2,1-2H3,(H,23,24,25)
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n/an/a 3.16E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM394013
PNG
(US9969749, Example 2-1)
Show SMILES CCOC(=O)c1cn(C)nc1-c1ccc2ncnc(N[C@H]3CC[C@@H](CC3)N3CCOCC3)c2c1
Show InChI InChI=1S/C25H32N6O3/c1-3-34-25(32)21-15-30(2)29-23(21)17-4-9-22-20(14-17)24(27-16-26-22)28-18-5-7-19(8-6-18)31-10-12-33-13-11-31/h4,9,14-16,18-19H,3,5-8,10-13H2,1-2H3,(H,26,27,28)/t18-,19-
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n/an/a 6.03E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
Interleukin-1 receptor-associated kinase 4


(Homo sapiens (Human))
BDBM393966
PNG
(US9969749, Example 1-57 | trans-N,N-dimethyl-N'- [...)
Show SMILES CN(C)[C@H]1CC[C@@H](CC1)Nc1ncnc2ccc(cc12)-c1cnc2N(C)CCOc2c1
Show InChI InChI=1S/C24H30N6O/c1-29(2)19-7-5-18(6-8-19)28-23-20-12-16(4-9-21(20)26-15-27-23)17-13-22-24(25-14-17)30(3)10-11-31-22/h4,9,12-15,18-19H,5-8,10-11H2,1-3H3,(H,26,27,28)/t18-,19-
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n/an/a 6.73E+3n/an/an/an/an/an/a



Merck Sharp & Dohme Corp.

US Patent


Assay Description
The kinase activity of IRAK4 is determined by its ability to catalyze the phosphorylation of a fluorescent polypeptide substrate. The extent of phosp...


US Patent US9969749 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%