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Patent code US9974785

Compile Data Set for Download or QSAR
Found 36 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394084
PNG
(US9974785, Example 3)
Show SMILES FC(F)c1cn(c2cccc(N3CCNCC3)c12)S(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C19H18ClF2N3O2S/c20-14-4-1-2-7-17(14)28(26,27)25-12-13(19(21)22)18-15(5-3-6-16(18)25)24-10-8-23-9-11-24/h1-7,12,19,23H,8-11H2
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0.430n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394083
PNG
(US9974785, Example 2)
Show SMILES FC(F)c1cn(c2cccc(N3CCNCC3)c12)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C19H18F3N3O2S/c20-14-4-1-2-7-17(14)28(26,27)25-12-13(19(21)22)18-15(5-3-6-16(18)25)24-10-8-23-9-11-24/h1-7,12,19,23H,8-11H2
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0.460n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394090
PNG
(US9974785, Example 10)
Show SMILES FC(F)c1cn(c2cccc(N3CCNCC3)c12)S(=O)(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H21F2N3O2S/c24-23(25)19-15-28(21-7-3-6-20(22(19)21)27-12-10-26-11-13-27)31(29,30)18-9-8-16-4-1-2-5-17(16)14-18/h1-9,14-15,23,26H,10-13H2
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0.5n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394086
PNG
(US9974785, Example 5)
Show SMILES FC(F)c1cn(c2cccc(N3CCNCC3)c12)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C19H18F3N3O2S/c20-13-3-1-4-14(11-13)28(26,27)25-12-15(19(21)22)18-16(5-2-6-17(18)25)24-9-7-23-8-10-24/h1-6,11-12,19,23H,7-10H2
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0.520n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394104
PNG
(US9974785, Example 25)
Show SMILES FC(F)c1cn(c2cc(Cl)cc(N3CCNCC3)c12)S(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C19H17Cl2F2N3O2S/c20-12-9-15(25-7-5-24-6-8-25)18-13(19(22)23)11-26(16(18)10-12)29(27,28)17-4-2-1-3-14(17)21/h1-4,9-11,19,24H,5-8H2
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0.680n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394087
PNG
(US9974785, Example 6)
Show SMILES FC(F)c1cn(c2cccc(N3CCNCC3)c12)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H18ClF2N3O2S/c20-13-3-1-4-14(11-13)28(26,27)25-12-15(19(21)22)18-16(5-2-6-17(18)25)24-9-7-23-8-10-24/h1-6,11-12,19,23H,7-10H2
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0.680n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394112
PNG
(US9974785, Example 42)
Show SMILES CN1CCN(CC1)c1cccc2n(cc(C(F)F)c12)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C20H20F3N3O2S/c1-24-8-10-25(11-9-24)17-6-3-7-18-19(17)16(20(22)23)13-26(18)29(27,28)15-5-2-4-14(21)12-15/h2-7,12-13,20H,8-11H2,1H3
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0.700n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394085
PNG
(US9974785, Example 4)
Show SMILES FC(F)c1cn(c2cccc(N3CCNCC3)c12)S(=O)(=O)c1ccccc1Br
Show InChI InChI=1S/C19H18BrF2N3O2S/c20-14-4-1-2-7-17(14)28(26,27)25-12-13(19(21)22)18-15(5-3-6-16(18)25)24-10-8-23-9-11-24/h1-7,12,19,23H,8-11H2
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1.10n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394105
PNG
(US9974785, Example 26)
Show SMILES FC(F)c1cn(c2cc(Cl)cc(N3CCNCC3)c12)S(=O)(=O)c1ccccc1Br
Show InChI InChI=1S/C19H17BrClF2N3O2S/c20-14-3-1-2-4-17(14)29(27,28)26-11-13(19(22)23)18-15(9-12(21)10-16(18)26)25-7-5-24-6-8-25/h1-4,9-11,19,24H,5-8H2
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1.10n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394108
PNG
(US9974785, Example 29)
Show SMILES FC(F)c1cn(c2cc(Cl)cc(N3CCNCC3)c12)S(=O)(=O)c1cccc(Br)c1
Show InChI InChI=1S/C19H17BrClF2N3O2S/c20-12-2-1-3-14(8-12)29(27,28)26-11-15(19(22)23)18-16(9-13(21)10-17(18)26)25-6-4-24-5-7-25/h1-3,8-11,19,24H,4-7H2
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1.30n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394107
PNG
(US9974785, Example 28)
Show SMILES FC(F)c1cn(c2cc(Cl)cc(N3CCNCC3)c12)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H17Cl2F2N3O2S/c20-12-2-1-3-14(8-12)29(27,28)26-11-15(19(22)23)18-16(9-13(21)10-17(18)26)25-6-4-24-5-7-25/h1-3,8-11,19,24H,4-7H2
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1.40n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394111
PNG
(US9974785, Example 37)
Show SMILES FC(F)c1cn(c2cc(Br)cc(N3CCNCC3)c12)S(=O)(=O)c1cccc(Br)c1
Show InChI InChI=1S/C19H17Br2F2N3O2S/c20-12-2-1-3-14(8-12)29(27,28)26-11-15(19(22)23)18-16(9-13(21)10-17(18)26)25-6-4-24-5-7-25/h1-3,8-11,19,24H,4-7H2
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1.5n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394103
PNG
(US9974785, Example 24)
Show SMILES FC(F)c1cn(c2cc(Cl)cc(N3CCNCC3)c12)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C19H17ClF3N3O2S/c20-12-9-15(25-7-5-24-6-8-25)18-13(19(22)23)11-26(16(18)10-12)29(27,28)17-4-2-1-3-14(17)21/h1-4,9-11,19,24H,5-8H2
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1.60n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394082
PNG
(US9974785, Example 1)
Show SMILES FC(F)c1cn(c2cccc(N3CCNCC3)c12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H19F2N3O2S/c20-19(21)15-13-24(27(25,26)14-5-2-1-3-6-14)17-8-4-7-16(18(15)17)23-11-9-22-10-12-23/h1-8,13,19,22H,9-12H2
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1.60n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394110
PNG
(US9974785, Example 36)
Show SMILES FC(F)c1cn(c2cc(Br)cc(N3CCNCC3)c12)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H17BrClF2N3O2S/c20-12-8-16(25-6-4-24-5-7-25)18-15(19(22)23)11-26(17(18)9-12)29(27,28)14-3-1-2-13(21)10-14/h1-3,8-11,19,24H,4-7H2
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1.70n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394106
PNG
(US9974785, Example 27)
Show SMILES FC(F)c1cn(c2cc(Cl)cc(N3CCNCC3)c12)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C19H17ClF3N3O2S/c20-12-8-16(25-6-4-24-5-7-25)18-15(19(22)23)11-26(17(18)9-12)29(27,28)14-3-1-2-13(21)10-14/h1-3,8-11,19,24H,4-7H2
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1.90n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394109
PNG
(US9974785, Example 35)
Show SMILES FC(F)c1cn(c2cc(Br)cc(N3CCNCC3)c12)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C19H17BrF3N3O2S/c20-12-8-16(25-6-4-24-5-7-25)18-15(19(22)23)11-26(17(18)9-12)29(27,28)14-3-1-2-13(21)10-14/h1-3,8-11,19,24H,4-7H2
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1.90n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394113
PNG
(US9974785, Example 43)
Show SMILES CCN1CCN(CC1)c1cccc2n(cc(C(F)F)c12)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C21H22F3N3O2S/c1-2-25-9-11-26(12-10-25)18-7-4-8-19-20(18)17(21(23)24)14-27(19)30(28,29)16-6-3-5-15(22)13-16/h3-8,13-14,21H,2,9-12H2,1H3
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2.30n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394088
PNG
(US9974785, Example 7)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1cc(C(F)F)c2c(cccc12)N1CCNCC1
Show InChI InChI=1S/C20H21F2N3O2S/c1-14-5-7-15(8-6-14)28(26,27)25-13-16(20(21)22)19-17(3-2-4-18(19)25)24-11-9-23-10-12-24/h2-8,13,20,23H,9-12H2,1H3
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6.40n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394102
PNG
(US9974785, Example 23)
Show SMILES FC(F)c1cn(c2cc(Cl)cc(N3CCNCC3)c12)S(=O)(=O)c1ccccc1C(F)(F)F
Show InChI InChI=1S/C20H17ClF5N3O2S/c21-12-9-15(28-7-5-27-6-8-28)18-13(19(22)23)11-29(16(18)10-12)32(30,31)17-4-2-1-3-14(17)20(24,25)26/h1-4,9-11,19,27H,5-8H2
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9.30n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394091
PNG
(US9974785, Example 11)
Show SMILES FC(F)c1cn(c2ccc(cc12)N1CCNCC1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H19F2N3O2S/c20-19(21)17-13-24(27(25,26)15-4-2-1-3-5-15)18-7-6-14(12-16(17)18)23-10-8-22-9-11-23/h1-7,12-13,19,22H,8-11H2
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11n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394116
PNG
(US9974785, Example 54)
Show SMILES FC(F)c1cn(c2cccc(NC3CCNCC3)c12)S(=O)(=O)c1cccc(Br)c1
Show InChI InChI=1S/C20H20BrF2N3O2S/c21-13-3-1-4-15(11-13)29(27,28)26-12-16(20(22)23)19-17(5-2-6-18(19)26)25-14-7-9-24-10-8-14/h1-6,11-12,14,20,24-25H,7-10H2
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11n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394089
PNG
(US9974785, Example 8)
Show SMILES COc1ccc(cc1)S(=O)(=O)n1cc(C(F)F)c2c(cccc12)N1CCNCC1
Show InChI InChI=1S/C20H21F2N3O3S/c1-28-14-5-7-15(8-6-14)29(26,27)25-13-16(20(21)22)19-17(3-2-4-18(19)25)24-11-9-23-10-12-24/h2-8,13,20,23H,9-12H2,1H3
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12n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394097
PNG
(US9974785, Example 17)
Show SMILES FC(F)c1cn(c2ccc(cc12)N1CCNCC1)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C19H18F3N3O2S/c20-13-2-1-3-15(10-13)28(26,27)25-12-17(19(21)22)16-11-14(4-5-18(16)25)24-8-6-23-7-9-24/h1-5,10-12,19,23H,6-9H2
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13n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394099
PNG
(US9974785, Example 19)
Show SMILES FC(F)c1cn(c2ccc(cc12)N1CCNCC1)S(=O)(=O)c1cccc(Br)c1
Show InChI InChI=1S/C19H18BrF2N3O2S/c20-13-2-1-3-15(10-13)28(26,27)25-12-17(19(21)22)16-11-14(4-5-18(16)25)24-8-6-23-7-9-24/h1-5,10-12,19,23H,6-9H2
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13n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394093
PNG
(US9974785, Example 13)
Show SMILES FC(F)c1cn(c2ccc(cc12)N1CCNCC1)S(=O)(=O)c1ccccc1Cl
Show InChI InChI=1S/C19H18ClF2N3O2S/c20-16-3-1-2-4-18(16)28(26,27)25-12-15(19(21)22)14-11-13(5-6-17(14)25)24-9-7-23-8-10-24/h1-6,11-12,19,23H,7-10H2
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13n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394098
PNG
(US9974785, Example 18)
Show SMILES FC(F)c1cn(c2ccc(cc12)N1CCNCC1)S(=O)(=O)c1cccc(Cl)c1
Show InChI InChI=1S/C19H18ClF2N3O2S/c20-13-2-1-3-15(10-13)28(26,27)25-12-17(19(21)22)16-11-14(4-5-18(16)25)24-8-6-23-7-9-24/h1-5,10-12,19,23H,6-9H2
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15n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394095
PNG
(US9974785, Example 15)
Show SMILES Cc1ccc(cc1)S(=O)(=O)n1cc(C(F)F)c2cc(ccc12)N1CCNCC1
Show InChI InChI=1S/C20H21F2N3O2S/c1-14-2-5-16(6-3-14)28(26,27)25-13-18(20(21)22)17-12-15(4-7-19(17)25)24-10-8-23-9-11-24/h2-7,12-13,20,23H,8-11H2,1H3
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17n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394115
PNG
(US9974785, Example 52)
Show SMILES FC(F)c1cn(c2cccc(NC3CCNCC3)c12)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C20H20F3N3O2S/c21-13-3-1-4-15(11-13)29(27,28)26-12-16(20(22)23)19-17(5-2-6-18(19)26)25-14-7-9-24-10-8-14/h1-6,11-12,14,20,24-25H,7-10H2
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18n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394094
PNG
(US9974785, Example 14)
Show SMILES FC(F)c1cn(c2ccc(cc12)N1CCNCC1)S(=O)(=O)c1ccccc1Br
Show InChI InChI=1S/C19H18BrF2N3O2S/c20-16-3-1-2-4-18(16)28(26,27)25-12-15(19(21)22)14-11-13(5-6-17(14)25)24-9-7-23-8-10-24/h1-6,11-12,19,23H,7-10H2
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20n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394114
PNG
(US9974785, Example 44)
Show SMILES CC(C)N1CCN(CC1)c1cccc2n(cc(C(F)F)c12)S(=O)(=O)c1cccc(F)c1
Show InChI InChI=1S/C22H24F3N3O2S/c1-15(2)26-9-11-27(12-10-26)19-7-4-8-20-21(19)18(22(24)25)14-28(20)31(29,30)17-6-3-5-16(23)13-17/h3-8,13-15,22H,9-12H2,1-2H3
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27n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394092
PNG
(US9974785, Example 12)
Show SMILES FC(F)c1cn(c2ccc(cc12)N1CCNCC1)S(=O)(=O)c1ccccc1F
Show InChI InChI=1S/C19H18F3N3O2S/c20-16-3-1-2-4-18(16)28(26,27)25-12-15(19(21)22)14-11-13(5-6-17(14)25)24-9-7-23-8-10-24/h1-6,11-12,19,23H,7-10H2
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30n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394101
PNG
(US9974785, Example 21)
Show SMILES FC(F)c1cn(c2ccc(cc12)N1CCNCC1)S(=O)(=O)c1ccc(Br)cc1
Show InChI InChI=1S/C19H18BrF2N3O2S/c20-13-1-4-15(5-2-13)28(26,27)25-12-17(19(21)22)16-11-14(3-6-18(16)25)24-9-7-23-8-10-24/h1-6,11-12,19,23H,7-10H2
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44n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394100
PNG
(US9974785, Example 20)
Show SMILES FC(F)c1cn(c2ccc(cc12)N1CCNCC1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H18ClF2N3O2S/c20-13-1-4-15(5-2-13)28(26,27)25-12-17(19(21)22)16-11-14(3-6-18(16)25)24-9-7-23-8-10-24/h1-6,11-12,19,23H,7-10H2
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44n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394117
PNG
(US9974785, Example 55)
Show SMILES FC(F)c1cn(c2cccc(NC3CCNCC3)c12)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C20H21F2N3O2S/c21-20(22)16-13-25(28(26,27)15-5-2-1-3-6-15)18-8-4-7-17(19(16)18)24-14-9-11-23-12-10-14/h1-8,13-14,20,23-24H,9-12H2
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65n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
Serotonin (5-HT) receptor


(Homo sapiens (Human))
BDBM394096
PNG
(US9974785, Example 16)
Show SMILES COc1ccc(cc1)S(=O)(=O)n1cc(C(F)F)c2cc(ccc12)N1CCNCC1
Show InChI InChI=1S/C20H21F2N3O3S/c1-28-15-3-5-16(6-4-15)29(26,27)25-13-18(20(21)22)17-12-14(2-7-19(17)25)24-10-8-23-9-11-24/h2-7,12-13,20,23H,8-11H2,1H3
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67n/an/an/an/an/an/an/an/a



Sunshine Lake Pharma Co., Ltd.

US Patent


Assay Description
32 μg membrane proteins of CHO cell expressing human 5-HT6 receptor, 2 nM of radioactive marker [3H]LSD, a compound of the present invention hav...


US Patent US9974785 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%