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Patent code US9975882

Compile Data Set for Download or QSAR

Found 212 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394245
PNG
(US9975882, Example 36)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(c4)C(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H27F2N7O2/c1-2-4-20(36)33-8-7-26(15-33)10-19(11-26)35-24(29)21(25(30)37)22(32-35)18-12-31-34(14-18)13-16-5-3-6-17(9-16)23(27)28/h3,5-6,9,12,14,19,23H,7-8,10-11,13,15,29H2,1H3,(H2,30,37)/t19-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394231
PNG
(US9975882, Example 22)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(c4)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H26F3N7O2/c1-2-4-20(37)34-8-7-25(15-34)10-19(11-25)36-23(30)21(24(31)38)22(33-36)17-12-32-35(14-17)13-16-5-3-6-18(9-16)26(27,28)29/h3,5-6,9,12,14,19H,7-8,10-11,13,15,30H2,1H3,(H2,31,38)/t19-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394262
PNG
(US9975882, Example 53)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(F)c4Cl)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H25ClFN7O2/c1-2-4-19(35)32-8-7-25(14-32)9-17(10-25)34-23(28)20(24(29)36)22(31-34)16-11-30-33(13-16)12-15-5-3-6-18(27)21(15)26/h3,5-6,11,13,17H,7-10,12,14,28H2,1H3,(H2,29,36)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394211
PNG
(US9975882, Example 2)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(Cl)c4)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H26ClN7O2/c1-2-4-20(34)31-8-7-25(15-31)10-19(11-25)33-23(27)21(24(28)35)22(30-33)17-12-29-32(14-17)13-16-5-3-6-18(26)9-16/h3,5-6,9,12,14,19H,7-8,10-11,13,15,27H2,1H3,(H2,28,35)/t19-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394260
PNG
(US9975882, Example 51)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(c4)C4CC4)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C28H31N7O2/c1-2-4-23(36)33-10-9-28(17-33)12-22(13-28)35-26(29)24(27(30)37)25(32-35)21-14-31-34(16-21)15-18-5-3-6-20(11-18)19-7-8-19/h3,5-6,11,14,16,19,22H,7-10,12-13,15,17,29H2,1H3,(H2,30,37)/t22-,28-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394253
PNG
(US9975882, Example 44)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4ccccc4)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H27N7O2/c1-2-6-20(33)30-10-9-25(16-30)11-19(12-25)32-23(26)21(24(27)34)22(29-32)18-13-28-31(15-18)14-17-7-4-3-5-8-17/h3-5,7-8,13,15,19H,9-12,14,16,26H2,1H3,(H2,27,34)/t19-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394237
PNG
(US9975882, Example 28)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(F)c4)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H26FN7O2/c1-2-4-20(34)31-8-7-25(15-31)10-19(11-25)33-23(27)21(24(28)35)22(30-33)17-12-29-32(14-17)13-16-5-3-6-18(26)9-16/h3,5-6,9,12,14,19H,7-8,10-11,13,15,27H2,1H3,(H2,28,35)/t19-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394268
PNG
(US9975882, Example 59)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(F)c4F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H25F2N7O2/c1-2-4-19(35)32-8-7-25(14-32)9-17(10-25)34-23(28)20(24(29)36)22(31-34)16-11-30-33(13-16)12-15-5-3-6-18(26)21(15)27/h3,5-6,11,13,17H,7-10,12,14,28H2,1H3,(H2,29,36)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394250
PNG
(US9975882, Example 41)
Show SMILES NC(=O)c1c(N)n(nc1-c1cnn(Cc2ccccc2)c1)[C@H]1C[C@]2(C1)CCN(C2)C(=O)C#CC1CC1
Show InChI InChI=1S/C27H29N7O2/c28-25-23(26(29)36)24(20-14-30-33(16-20)15-19-4-2-1-3-5-19)31-34(25)21-12-27(13-21)10-11-32(17-27)22(35)9-8-18-6-7-18/h1-5,14,16,18,21H,6-7,10-13,15,17,28H2,(H2,29,36)/t21-,27-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394267
PNG
(US9975882, Example 58)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4ccc(Cl)c(c4)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H25ClF3N7O2/c1-2-3-20(38)35-7-6-25(14-35)9-17(10-25)37-23(31)21(24(32)39)22(34-37)16-11-33-36(13-16)12-15-4-5-19(27)18(8-15)26(28,29)30/h4-5,8,11,13,17H,6-7,9-10,12,14,31H2,1H3,(H2,32,39)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394212
PNG
(US9975882, Example 3)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(c4Cl)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H25ClF3N7O2/c1-2-4-19(38)35-8-7-25(14-35)9-17(10-25)37-23(31)20(24(32)39)22(34-37)16-11-33-36(13-16)12-15-5-3-6-18(21(15)27)26(28,29)30/h3,5-6,11,13,17H,7-10,12,14,31H2,1H3,(H2,32,39)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394215
PNG
(US9975882, Example 6)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(c4C)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C27H28F3N7O2/c1-3-5-21(38)35-9-8-26(15-35)10-19(11-26)37-24(31)22(25(32)39)23(34-37)18-12-33-36(14-18)13-17-6-4-7-20(16(17)2)27(28,29)30/h4,6-7,12,14,19H,8-11,13,15,31H2,1-2H3,(H2,32,39)/t19-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394214
PNG
(US9975882, Example 5)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4ccc(C)c(c4)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C27H28F3N7O2/c1-3-4-21(38)35-8-7-26(15-35)10-19(11-26)37-24(31)22(25(32)39)23(34-37)18-12-33-36(14-18)13-17-6-5-16(2)20(9-17)27(28,29)30/h5-6,9,12,14,19H,7-8,10-11,13,15,31H2,1-2H3,(H2,32,39)/t19-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394242
PNG
(US9975882, Example 33)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(c4F)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H25F4N7O2/c1-2-4-19(38)35-8-7-25(14-35)9-17(10-25)37-23(31)20(24(32)39)22(34-37)16-11-33-36(13-16)12-15-5-3-6-18(21(15)27)26(28,29)30/h3,5-6,11,13,17H,7-10,12,14,31H2,1H3,(H2,32,39)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394221
PNG
(US9975882, Example 12)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4ccccc4C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H26F3N7O2/c1-2-5-20(37)34-9-8-25(15-34)10-18(11-25)36-23(30)21(24(31)38)22(33-36)17-12-32-35(14-17)13-16-6-3-4-7-19(16)26(27,28)29/h3-4,6-7,12,14,18H,8-11,13,15,30H2,1H3,(H2,31,38)/t18-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394219
PNG
(US9975882, Example 10)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(c4C#N)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C27H25F3N8O2/c1-2-4-21(39)36-8-7-26(15-36)9-18(10-26)38-24(32)22(25(33)40)23(35-38)17-12-34-37(14-17)13-16-5-3-6-20(19(16)11-31)27(28,29)30/h3,5-6,12,14,18H,7-10,13,15,32H2,1H3,(H2,33,40)/t18-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394223
PNG
(US9975882, Example 14)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(n4)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H25F3N8O2/c1-2-4-19(37)34-8-7-24(14-34)9-17(10-24)36-22(29)20(23(30)38)21(33-36)15-11-31-35(12-15)13-16-5-3-6-18(32-16)25(26,27)28/h3,5-6,11-12,17H,7-10,13-14,29H2,1H3,(H2,30,38)/t17-,24-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394269
PNG
(US9975882, Example 60)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4ccccc4F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H26FN7O2/c1-2-5-20(34)31-9-8-25(15-31)10-18(11-25)33-23(27)21(24(28)35)22(30-33)17-12-29-32(14-17)13-16-6-3-4-7-19(16)26/h3-4,6-7,12,14,18H,8-11,13,15,27H2,1H3,(H2,28,35)/t18-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394263
PNG
(US9975882, Example 54)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4ccccc4Cl)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H26ClN7O2/c1-2-5-20(34)31-9-8-25(15-31)10-18(11-25)33-23(27)21(24(28)35)22(30-33)17-12-29-32(14-17)13-16-6-3-4-7-19(16)26/h3-4,6-7,12,14,18H,8-11,13,15,27H2,1H3,(H2,28,35)/t18-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394241
PNG
(US9975882, Example 32)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cc(ccc4F)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H25F4N7O2/c1-2-3-20(38)35-7-6-25(14-35)9-18(10-25)37-23(31)21(24(32)39)22(34-37)16-11-33-36(13-16)12-15-8-17(26(28,29)30)4-5-19(15)27/h4-5,8,11,13,18H,6-7,9-10,12,14,31H2,1H3,(H2,32,39)/t18-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394256
PNG
(US9975882, Example 47)
Show SMILES CC#CC(=O)N1CC2(CC(C2)n2nc(-c3cnn(Cc4cccc(c4)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H24F3N7O2/c1-2-4-19(36)33-13-24(14-33)8-18(9-24)35-22(29)20(23(30)37)21(32-35)16-10-31-34(12-16)11-15-5-3-6-17(7-15)25(26,27)28/h3,5-7,10,12,18H,8-9,11,13-14,29H2,1H3,(H2,30,37)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394218
PNG
(US9975882, Example 9)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4ccccc4OC(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H26F3N7O3/c1-2-5-20(37)34-9-8-25(15-34)10-18(11-25)36-23(30)21(24(31)38)22(33-36)17-12-32-35(14-17)13-16-6-3-4-7-19(16)39-26(27,28)29/h3-4,6-7,12,14,18H,8-11,13,15,30H2,1H3,(H2,31,38)/t18-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394239
PNG
(US9975882, Example 30)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4ccc(F)c(c4)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H25F4N7O2/c1-2-3-20(38)35-7-6-25(14-35)9-17(10-25)37-23(31)21(24(32)39)22(34-37)16-11-33-36(13-16)12-15-4-5-19(27)18(8-15)26(28,29)30/h4-5,8,11,13,17H,6-7,9-10,12,14,31H2,1H3,(H2,32,39)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394265
PNG
(US9975882, Example 56)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(F)c4C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H25F4N7O2/c1-2-4-19(38)35-8-7-25(14-35)9-17(10-25)37-23(31)20(24(32)39)22(34-37)16-11-33-36(13-16)12-15-5-3-6-18(27)21(15)26(28,29)30/h3,5-6,11,13,17H,7-10,12,14,31H2,1H3,(H2,32,39)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394227
PNG
(US9975882, Example 18)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(c3)[C@H](C)c3cccc(c3)C(F)(F)F)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C27H28F3N7O2/c1-3-5-21(38)35-9-8-26(15-35)11-20(12-26)37-24(31)22(25(32)39)23(34-37)18-13-33-36(14-18)16(2)17-6-4-7-19(10-17)27(28,29)30/h4,6-7,10,13-14,16,20H,8-9,11-12,15,31H2,1-2H3,(H2,32,39)/t16-,20-,26-/m1/s1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394231
PNG
(US9975882, Example 22)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(c4)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H26F3N7O2/c1-2-4-20(37)34-8-7-25(15-34)10-19(11-25)36-23(30)21(24(31)38)22(33-36)17-12-32-35(14-17)13-16-5-3-6-18(9-16)26(27,28)29/h3,5-6,9,12,14,19H,7-8,10-11,13,15,30H2,1H3,(H2,31,38)/t19-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394220
PNG
(US9975882, Example 11)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4ccccc4C#N)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H26N8O2/c1-2-5-21(35)32-9-8-26(16-32)10-20(11-26)34-24(28)22(25(29)36)23(31-34)19-13-30-33(15-19)14-18-7-4-3-6-17(18)12-27/h3-4,6-7,13,15,20H,8-11,14,16,28H2,1H3,(H2,29,36)/t20-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394264
PNG
(US9975882, Example 55)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cc(F)ccc4Cl)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H25ClFN7O2/c1-2-3-20(35)32-7-6-25(14-32)9-18(10-25)34-23(28)21(24(29)36)22(31-34)16-11-30-33(13-16)12-15-8-17(27)4-5-19(15)26/h4-5,8,11,13,18H,6-7,9-10,12,14,28H2,1H3,(H2,29,36)/t18-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394243
PNG
(US9975882, Example 34)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cn(Cc4cccc(Cl)c4)nc3C)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H28ClN7O2/c1-3-5-21(35)32-9-8-26(15-32)11-19(12-26)34-24(28)22(25(29)36)23(31-34)20-14-33(30-16(20)2)13-17-6-4-7-18(27)10-17/h4,6-7,10,14,19H,8-9,11-13,15,28H2,1-2H3,(H2,29,36)/t19-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394268
PNG
(US9975882, Example 59)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(F)c4F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H25F2N7O2/c1-2-4-19(35)32-8-7-25(14-32)9-17(10-25)34-23(28)20(24(29)36)22(31-34)16-11-30-33(13-16)12-15-5-3-6-18(26)21(15)27/h3,5-6,11,13,17H,7-10,12,14,28H2,1H3,(H2,29,36)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Cytoplasmic tyrosine-protein kinase BMX


(Homo sapiens (Human))
BDBM1773
PNG
(US10280174, Comparative Compound 1 | US8476284, 4 ...)
Show SMILES Nc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCN(C1)C(=O)C=C
Show InChI InChI=1S/C25H24N6O2/c1-2-21(32)30-14-6-7-18(15-30)31-25-22(24(26)27-16-28-25)23(29-31)17-10-12-20(13-11-17)33-19-8-4-3-5-9-19/h2-5,8-13,16,18H,1,6-7,14-15H2,(H2,26,27,28)
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394211
PNG
(US9975882, Example 2)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(Cl)c4)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H26ClN7O2/c1-2-4-20(34)31-8-7-25(15-31)10-19(11-25)33-23(27)21(24(28)35)22(30-33)17-12-29-32(14-17)13-16-5-3-6-18(26)9-16/h3,5-6,9,12,14,19H,7-8,10-11,13,15,27H2,1H3,(H2,28,35)/t19-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394233
PNG
(US9975882, Example 24)
Show SMILES CNc1c(C(N)=O)c(nn1[C@H]1C[C@]2(C1)CCN(C2)C(=O)C#CC)-c1cnn(Cc2cccc(c2)C2CC2)c1
Show InChI InChI=1S/C29H33N7O2/c1-3-5-24(37)34-11-10-29(18-34)13-23(14-29)36-28(31-2)25(27(30)38)26(33-36)22-15-32-35(17-22)16-19-6-4-7-21(12-19)20-8-9-20/h4,6-7,12,15,17,20,23,31H,8-11,13-14,16,18H2,1-2H3,(H2,30,38)/t23-,29-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394246
PNG
(US9975882, Example 37)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cn(Cc4cccc(c4)C4CC4)nc3C)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C29H33N7O2/c1-3-5-24(37)34-11-10-29(17-34)13-22(14-29)36-27(30)25(28(31)38)26(33-36)23-16-35(32-18(23)2)15-19-6-4-7-21(12-19)20-8-9-20/h4,6-7,12,16,20,22H,8-11,13-15,17,30H2,1-2H3,(H2,31,38)/t22-,29-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394238
PNG
(US9975882, Example 29)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4ccc(F)cc4)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H26FN7O2/c1-2-3-20(34)31-9-8-25(15-31)10-19(11-25)33-23(27)21(24(28)35)22(30-33)17-12-29-32(14-17)13-16-4-6-18(26)7-5-16/h4-7,12,14,19H,8-11,13,15,27H2,1H3,(H2,28,35)/t19-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394260
PNG
(US9975882, Example 51)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(c4)C4CC4)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C28H31N7O2/c1-2-4-23(36)33-10-9-28(17-33)12-22(13-28)35-26(29)24(27(30)37)25(32-35)21-14-31-34(16-21)15-18-5-3-6-20(11-18)19-7-8-19/h3,5-6,11,14,16,19,22H,7-10,12-13,15,17,29H2,1H3,(H2,30,37)/t22-,28-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394240
PNG
(US9975882, Example 31)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cc(F)cc(c4)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H25F4N7O2/c1-2-3-20(38)35-5-4-25(14-35)9-19(10-25)37-23(31)21(24(32)39)22(34-37)16-11-33-36(13-16)12-15-6-17(26(28,29)30)8-18(27)7-15/h6-8,11,13,19H,4-5,9-10,12,14,31H2,1H3,(H2,32,39)/t19-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394266
PNG
(US9975882, Example 57)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cc(F)ccc4C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H25F4N7O2/c1-2-3-20(38)35-7-6-25(14-35)9-18(10-25)37-23(31)21(24(32)39)22(34-37)16-11-33-36(13-16)12-15-8-17(27)4-5-19(15)26(28,29)30/h4-5,8,11,13,18H,6-7,9-10,12,14,31H2,1H3,(H2,32,39)/t18-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394244
PNG
(US9975882, Example 35)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cn(Cc4cccc(c4)C(F)F)nc3C)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C27H29F2N7O2/c1-3-5-21(37)34-9-8-27(15-34)11-19(12-27)36-25(30)22(26(31)38)23(33-36)20-14-35(32-16(20)2)13-17-6-4-7-18(10-17)24(28)29/h4,6-7,10,14,19,24H,8-9,11-13,15,30H2,1-2H3,(H2,31,38)/t19-,27-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394271
PNG
(5-amino-1-(7-but-2-ynoyl-7-azaspiro[3.4]octan-2-yl...)
Show SMILES CC#CC(=O)N1CCC2(CC(C2)C2(CC=C(OC(C)C)C(N)=C2)NC(=O)c2cn[nH]c2)C1
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394217
PNG
(US9975882, Example 8)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cc(ccc4Cl)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H25ClF3N7O2/c1-2-3-20(38)35-7-6-25(14-35)9-18(10-25)37-23(31)21(24(32)39)22(34-37)16-11-33-36(13-16)12-15-8-17(26(28,29)30)4-5-19(15)27/h4-5,8,11,13,18H,6-7,9-10,12,14,31H2,1H3,(H2,32,39)/t18-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394248
PNG
(US9975882, Example 39)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cc(Cl)cc(c4)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H25ClF3N7O2/c1-2-3-20(38)35-5-4-25(14-35)9-19(10-25)37-23(31)21(24(32)39)22(34-37)16-11-33-36(13-16)12-15-6-17(26(28,29)30)8-18(27)7-15/h6-8,11,13,19H,4-5,9-10,12,14,31H2,1H3,(H2,32,39)/t19-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394228
PNG
(US9975882, Example 19)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cn(Cc4cccc(c4)C(F)(F)F)nc3C)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C27H28F3N7O2/c1-3-5-21(38)35-9-8-26(15-35)11-19(12-26)37-24(31)22(25(32)39)23(34-37)20-14-36(33-16(20)2)13-17-6-4-7-18(10-17)27(28,29)30/h4,6-7,10,14,19H,8-9,11-13,15,31H2,1-2H3,(H2,32,39)/t19-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394245
PNG
(US9975882, Example 36)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(c4)C(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H27F2N7O2/c1-2-4-20(36)33-8-7-26(15-33)10-19(11-26)35-24(29)21(25(30)37)22(32-35)18-12-31-34(14-18)13-16-5-3-6-17(9-16)23(27)28/h3,5-6,9,12,14,19,23H,7-8,10-11,13,15,29H2,1H3,(H2,30,37)/t19-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394224
PNG
(US9975882, Example 15)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(c3)C(C)c3cccc(c3)C(F)(F)F)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C27H28F3N7O2/c1-3-5-21(38)35-9-8-26(15-35)11-20(12-26)37-24(31)22(25(32)39)23(34-37)18-13-33-36(14-18)16(2)17-6-4-7-19(10-17)27(28,29)30/h4,6-7,10,13-14,16,20H,8-9,11-12,15,31H2,1-2H3,(H2,32,39)/t16?,20-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394237
PNG
(US9975882, Example 28)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(F)c4)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H26FN7O2/c1-2-4-20(34)31-8-7-25(15-31)10-19(11-25)33-23(27)21(24(28)35)22(30-33)17-12-29-32(14-17)13-16-5-3-6-18(26)9-16/h3,5-6,9,12,14,19H,7-8,10-11,13,15,27H2,1H3,(H2,28,35)/t19-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394261
PNG
(US9975882, Example 52)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cn(Cc4cccc(C)c4)nc3C)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C27H31N7O2/c1-4-6-22(35)32-10-9-27(16-32)12-20(13-27)34-25(28)23(26(29)36)24(31-34)21-15-33(30-18(21)3)14-19-8-5-7-17(2)11-19/h5,7-8,11,15,20H,9-10,12-14,16,28H2,1-3H3,(H2,29,36)/t20-,27-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394212
PNG
(US9975882, Example 3)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(c4Cl)C(F)(F)F)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C26H25ClF3N7O2/c1-2-4-19(38)35-8-7-25(14-35)9-17(10-25)37-23(31)20(24(32)39)22(34-37)16-11-33-36(13-16)12-15-5-3-6-18(21(15)27)26(28,29)30/h3,5-6,11,13,17H,7-10,12,14,31H2,1H3,(H2,32,39)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394262
PNG
(US9975882, Example 53)
Show SMILES CC#CC(=O)N1CC[C@@]2(C[C@@H](C2)n2nc(-c3cnn(Cc4cccc(F)c4Cl)c3)c(C(N)=O)c2N)C1
Show InChI InChI=1S/C25H25ClFN7O2/c1-2-4-19(35)32-8-7-25(14-32)9-17(10-25)34-23(28)20(24(29)36)22(31-34)16-11-30-33(13-16)12-15-5-3-6-18(27)21(15)26/h3,5-6,11,13,17H,7-10,12,14,28H2,1H3,(H2,29,36)/t17-,25-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Tyrosine-protein kinase BTK


(Homo sapiens (Human))
BDBM394232
PNG
(US9975882, Example 23)
Show SMILES CNc1c(C(N)=O)c(nn1[C@H]1C[C@]2(C1)CCN(C2)C(=O)C#CC)-c1cnn(Cc2cccc(c2)C(F)(F)F)c1
Show InChI InChI=1S/C27H28F3N7O2/c1-3-5-21(38)35-9-8-26(16-35)11-20(12-26)37-25(32-2)22(24(31)39)23(34-37)18-13-33-36(15-18)14-17-6-4-7-19(10-17)27(28,29)30/h4,6-7,10,13,15,20,32H,8-9,11-12,14,16H2,1-2H3,(H2,31,39)/t20-,26-
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Boehringer Ingelheim International GmbH

US Patent


Assay Description
Lanthscreen Eu Kinase Binding assay for BMX is performed as described above for BTK except that 1 nM human recombinant full length TEC (His-tagged) k...


US Patent US9975882 (2018)


BindingDB Entry DOI: 10.7270/Q2BP0531
More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 212 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%