BindingDB logo
myBDB logout

Patent code US9975907

Compile Data Set for Download or QSAR
Found 123 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394323
PNG
(US9975907, Example 43)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1Cl
Show InChI InChI=1/C20H16ClN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-5-3-4-6-13(12)21/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394319
PNG
(US9975907, Example 39)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1Cl
Show InChI InChI=1/C20H17ClN8OS/c1-9-7-31-20-26-14(13(18(30)29(9)20)11-5-3-4-6-12(11)21)10(2)25-17-15-16(24-8-23-15)27-19(22)28-17/h3-8,10H,1-2H3,(H4,22,23,24,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 1n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394283
PNG
(US9975907, Example 2)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1
Show InChI InChI=1/C23H21N7O/c1-3-16(28-22-20-21(25-12-24-20)26-13-27-22)19-18(15-9-5-4-6-10-15)23(31)30-14(2)8-7-11-17(30)29-19/h4-13,16H,3H2,1-2H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394289
PNG
(US9975907, Example 8)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
Show InChI InChI=1/C20H17N7OS/c1-11-8-29-20-26-15(14(19(28)27(11)20)13-6-4-3-5-7-13)12(2)25-18-16-17(22-9-21-16)23-10-24-18/h3-10,12H,1-2H3,(H2,21,22,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US9975907, Example 13 | US9975907, Example 23)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H16F2N8OS/c1-8-6-32-20-27-14(9(2)26-17-15-16(25-7-24-15)28-19(23)29-17)13(18(31)30(8)20)10-3-11(21)5-12(22)4-10/h3-7,9H,1-2H3,(H4,23,24,25,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394340
PNG
(US9975907, Example 60)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1F
Show InChI InChI=1/C22H19FN8O/c1-11-6-5-9-15-28-17(16(21(32)31(11)15)13-7-3-4-8-14(13)23)12(2)27-20-18-19(26-10-25-18)29-22(24)30-20/h3-10,12H,1-2H3,(H4,24,25,26,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394358
PNG
(US9975907, Example 78)
Show SMILES CCc1cccc2nc(C(C)Nc3ncnc4[nH]cnc34)c(-c3ccc(F)cc3)c(=O)n12
Show InChI InChI=1/C23H20FN7O/c1-3-16-5-4-6-17-30-19(13(2)29-22-20-21(26-11-25-20)27-12-28-22)18(23(32)31(16)17)14-7-9-15(24)10-8-14/h4-13H,3H2,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394292
PNG
(US9975907, Example 11)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H17FN8OS/c1-9-7-31-20-26-14(13(18(30)29(9)20)11-4-3-5-12(21)6-11)10(2)25-17-15-16(24-8-23-15)27-19(22)28-17/h3-8,10H,1-2H3,(H4,22,23,24,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US9975907, Example 12 | US9975907, Example 44)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H15F2N7OS/c1-9-6-31-20-28-15(10(2)27-18-16-17(24-7-23-16)25-8-26-18)14(19(30)29(9)20)11-3-12(21)5-13(22)4-11/h3-8,10H,1-2H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US9975907, Example 13 | US9975907, Example 23)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H16F2N8OS/c1-8-6-32-20-27-14(9(2)26-17-15-16(25-7-24-15)28-19(23)29-17)13(18(31)30(8)20)10-3-11(21)5-12(22)4-10/h3-7,9H,1-2H3,(H4,23,24,25,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394314
PNG
(US9975907, Example 34)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1F
Show InChI InChI=1/C20H16F2N8OS/c1-8-6-32-20-27-14(9(2)26-17-15-16(25-7-24-15)28-19(23)29-17)12(18(31)30(8)20)10-4-3-5-11(21)13(10)22/h3-7,9H,1-2H3,(H4,23,24,25,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394339
PNG
(US9975907, Example 59)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1F
Show InChI InChI=1/C22H18FN7O/c1-12-6-5-9-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-7-3-4-8-15(14)23/h3-11,13H,1-2H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394354
PNG
(2-{1-[(2-Amino-9H-purin-6-yl)amino]ethyl}-3-(3-flu...)
Show SMILES C[C@@H](Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C22H19FN8O/c1-11-5-3-8-15-28-17(16(21(32)31(11)15)13-6-4-7-14(23)9-13)12(2)27-20-18-19(26-10-25-18)29-22(24)30-20/h3-10,12H,1-2H3,(H4,24,25,26,27,29,30)/t12-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394290
PNG
(US9975907, Example 9)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
Show InChI InChI=1/C20H18N8OS/c1-10-8-30-20-25-14(13(18(29)28(10)20)12-6-4-3-5-7-12)11(2)24-17-15-16(23-9-22-15)26-19(21)27-17/h3-9,11H,1-2H3,(H4,21,22,23,24,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50004547
PNG
(CHEMBL2216863 | US10065963, Compound 28 | US970833...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US9975907, Example 12 | US9975907, Example 44)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H15F2N7OS/c1-9-6-31-20-28-15(10(2)27-18-16-17(24-7-23-16)25-8-26-18)14(19(30)29(9)20)11-3-12(21)5-13(22)4-11/h3-8,10H,1-2H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394329
PNG
(US9975907, Example 49)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1
Show InChI InChI=1/C22H19N7O/c1-13-7-6-10-16-28-18(17(22(30)29(13)16)15-8-4-3-5-9-15)14(2)27-21-19-20(24-11-23-19)25-12-26-21/h3-12,14H,1-2H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394344
PNG
(US9975907, Example 64)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(C)cc1
Show InChI InChI=1/C23H21N7O/c1-13-7-9-16(10-8-13)18-19(29-17-6-4-5-14(2)30(17)23(18)31)15(3)28-22-20-21(25-11-24-20)26-12-27-22/h4-12,15H,1-3H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US9975907, Example 12 | US9975907, Example 44)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H15F2N7OS/c1-9-6-31-20-28-15(10(2)27-18-16-17(24-7-23-16)25-8-26-18)14(19(30)29(9)20)11-3-12(21)5-13(22)4-11/h3-8,10H,1-2H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US9975907, Example 13 | US9975907, Example 23)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H16F2N8OS/c1-8-6-32-20-27-14(9(2)26-17-15-16(25-7-24-15)28-19(23)29-17)13(18(31)30(8)20)10-3-11(21)5-12(22)4-10/h3-7,9H,1-2H3,(H4,23,24,25,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394320
PNG
(US9975907, Example 40)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1F
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-5-3-4-6-13(12)21/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394325
PNG
(US9975907, Example 45)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)ccc1F
Show InChI InChI=1/C20H15F2N7OS/c1-9-6-31-20-28-15(10(2)27-18-16-17(24-7-23-16)25-8-26-18)14(19(30)29(9)20)12-5-11(21)3-4-13(12)22/h3-8,10H,1-2H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394345
PNG
(US9975907, Example 65)
Show SMILES COc1cccc(c1)-c1c(nc2cccc(C)n2c1=O)C(C)Nc1ncnc2[nH]cnc12
Show InChI InChI=1/C23H21N7O2/c1-13-6-4-9-17-29-19(14(2)28-22-20-21(25-11-24-20)26-12-27-22)18(23(31)30(13)17)15-7-5-8-16(10-15)32-3/h4-12,14H,1-3H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM50004547
PNG
(CHEMBL2216863 | US10065963, Compound 28 | US970833...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394313
PNG
(US9975907, Example 33)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1F
Show InChI InChI=1/C20H17FN8OS/c1-9-7-31-20-26-14(13(18(30)29(9)20)11-5-3-4-6-12(11)21)10(2)25-17-15-16(24-8-23-15)27-19(22)28-17/h3-8,10H,1-2H3,(H4,22,23,24,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US9975907, Example 12 | US9975907, Example 44)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H15F2N7OS/c1-9-6-31-20-28-15(10(2)27-18-16-17(24-7-23-16)25-8-26-18)14(19(30)29(9)20)11-3-12(21)5-13(22)4-11/h3-8,10H,1-2H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394338
PNG
(US9975907, Example 58)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1Cl
Show InChI InChI=1/C22H19ClN8O/c1-11-6-5-9-15-28-17(16(21(32)31(11)15)13-7-3-4-8-14(13)23)12(2)27-20-18-19(26-10-25-18)29-22(24)30-20/h3-10,12H,1-2H3,(H4,24,25,26,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394300
PNG
(US9975907, Example 20)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1nccs1
Show InChI InChI=1/C17H14N8OS2/c1-8-5-28-17-24-11(10(16(26)25(8)17)15-18-3-4-27-15)9(2)23-14-12-13(20-6-19-12)21-7-22-14/h3-7,9H,1-2H3,(H2,19,20,21,22,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394326
PNG
(US9975907, Example 46)
Show SMILES C[C@H](Nc1ccnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C21H17FN6OS/c1-11-9-30-21-27-17(12(2)26-15-6-7-23-19-18(15)24-10-25-19)16(20(29)28(11)21)13-4-3-5-14(22)8-13/h3-10,12H,1-2H3,(H2,23,24,25,26)/t12-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394332
PNG
(US9975907, Example 52)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(C)c1
Show InChI InChI=1/C23H22N8O/c1-12-6-4-8-15(10-12)17-18(28-16-9-5-7-13(2)31(16)22(17)32)14(3)27-21-19-20(26-11-25-19)29-23(24)30-21/h4-11,14H,1-3H3,(H4,24,25,26,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394337
PNG
(US9975907, Example 57)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1Cl
Show InChI InChI=1/C22H18ClN7O/c1-12-6-5-9-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-7-3-4-8-15(14)23/h3-11,13H,1-2H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM124076
PNG
(US8754089, 3-(3-fluorophenyl)-6-methyl-2-((1R)-1-(...)
Show SMILES C[C@@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C22H18FN7O/c1-12-5-3-8-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-6-4-7-15(23)9-14/h3-11,13H,1-2H3,(H2,24,25,26,27,28)/t13-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394290
PNG
(US9975907, Example 9)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
Show InChI InChI=1/C20H18N8OS/c1-10-8-30-20-25-14(13(18(29)28(10)20)12-6-4-3-5-7-12)11(2)24-17-15-16(23-9-22-15)26-19(21)27-17/h3-9,11H,1-2H3,(H4,21,22,23,24,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394292
PNG
(US9975907, Example 11)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H17FN8OS/c1-9-7-31-20-26-14(13(18(30)29(9)20)11-4-3-5-12(21)6-11)10(2)25-17-15-16(24-8-23-15)27-19(22)28-17/h3-8,10H,1-2H3,(H4,22,23,24,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394301
PNG
(US9975907, Example 21)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cscn1
Show InChI InChI=1/C17H14N8OS2/c1-8-3-28-17-24-12(11(16(26)25(8)17)10-4-27-7-22-10)9(2)23-15-13-14(19-5-18-13)20-6-21-15/h3-7,9H,1-2H3,(H2,18,19,20,21,23)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394330
PNG
(US9975907, Example 50)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1
Show InChI InChI=1/C22H20N8O/c1-12-7-6-10-15-27-17(16(21(31)30(12)15)14-8-4-3-5-9-14)13(2)26-20-18-19(25-11-24-18)28-22(23)29-20/h3-11,13H,1-2H3,(H4,23,24,25,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394334
PNG
(US9975907, Example 54)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(Cl)c1
Show InChI InChI=1/C22H19ClN8O/c1-11-5-3-8-15-28-17(16(21(32)31(11)15)13-6-4-7-14(23)9-13)12(2)27-20-18-19(26-10-25-18)29-22(24)30-20/h3-10,12H,1-2H3,(H4,24,25,26,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394346
PNG
(US9975907, Example 66)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1F
Show InChI InChI=1/C22H17F2N7O/c1-11-5-3-8-15-30-18(12(2)29-21-19-20(26-9-25-19)27-10-28-21)16(22(32)31(11)15)13-6-4-7-14(23)17(13)24/h3-10,12H,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394347
PNG
(US9975907, Example 67)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cc(F)ccc1F
Show InChI InChI=1/C22H17F2N7O/c1-11-4-3-5-16-30-18(12(2)29-21-19-20(26-9-25-19)27-10-28-21)17(22(32)31(11)16)14-8-13(23)6-7-15(14)24/h3-10,12H,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394353
PNG
(US9975907, Example 73)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C22H19FN8O/c1-11-5-3-8-15-28-17(16(21(32)31(11)15)13-6-4-7-14(23)9-13)12(2)27-20-18-19(26-10-25-18)29-22(24)30-20/h3-10,12H,1-2H3,(H4,24,25,26,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<50n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394295
PNG
(US9975907, Example 14)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccn1
Show InChI InChI=1/C19H16N8OS/c1-10-7-29-19-26-14(13(18(28)27(10)19)12-5-3-4-6-20-12)11(2)25-17-15-16(22-8-21-15)23-9-24-17/h3-9,11H,1-2H3,(H2,21,22,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM124079
PNG
(US8754089, 3-(3-fluorophenyl)-6-methyl-2-(1-(9H-pu...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C22H18FN7O/c1-12-5-3-8-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-6-4-7-15(23)9-14/h3-11,13H,1-2H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394283
PNG
(US9975907, Example 2)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1
Show InChI InChI=1/C23H21N7O/c1-3-16(28-22-20-21(25-12-24-20)26-13-27-22)19-18(15-9-5-4-6-10-15)23(31)30-14(2)8-7-11-17(30)29-19/h4-13,16H,3H2,1-2H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394288
PNG
(US9975907, Example 7)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cn[nH]c1
Show InChI InChI=1/C20H19N9O/c1-3-13(27-19-17-18(22-9-21-17)23-10-24-19)16-15(12-7-25-26-8-12)20(30)29-11(2)5-4-6-14(29)28-16/h4-10,13H,3H2,1-2H3,(H,25,26)(H2,21,22,23,24,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394289
PNG
(US9975907, Example 8)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
Show InChI InChI=1/C20H17N7OS/c1-11-8-29-20-26-15(14(19(28)27(11)20)13-6-4-3-5-7-13)12(2)25-18-16-17(22-9-21-16)23-10-24-18/h3-10,12H,1-2H3,(H2,21,22,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394285
PNG
(US9975907, Example 4)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C23H20FN7O/c1-3-16(29-22-20-21(26-11-25-20)27-12-28-22)19-18(14-7-5-8-15(24)10-14)23(32)31-13(2)6-4-9-17(31)30-19/h4-12,16H,3H2,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394286
PNG
(US9975907, Example 5)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C23H19F2N7O/c1-3-16(30-22-20-21(27-10-26-20)28-11-29-22)19-18(13-7-14(24)9-15(25)8-13)23(33)32-12(2)5-4-6-17(32)31-19/h4-11,16H,3H2,1-2H3,(H2,26,27,28,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394318
PNG
(US9975907, Example 38)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cncc(F)c1
Show InChI InChI=1/C19H16FN9OS/c1-8-6-31-19-26-13(12(17(30)29(8)19)10-3-11(20)5-22-4-10)9(2)25-16-14-15(24-7-23-14)27-18(21)28-16/h3-7,9H,1-2H3,(H4,21,23,24,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394295
PNG
(US9975907, Example 14)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccn1
Show InChI InChI=1/C19H16N8OS/c1-10-7-29-19-26-14(13(18(28)27(10)19)12-5-3-4-6-20-12)11(2)25-17-15-16(22-8-21-15)23-9-24-17/h3-9,11H,1-2H3,(H2,21,22,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394321
PNG
(US9975907, Example 41)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1F
Show InChI InChI=1/C20H15F2N7OS/c1-9-6-31-20-28-15(10(2)27-18-16-17(24-7-23-16)25-8-26-18)13(19(30)29(9)20)11-4-3-5-12(21)14(11)22/h3-8,10H,1-2H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394364
PNG
(US9975907, Example 84)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(c1)C#N
Show InChI InChI=1/C23H19N9O/c1-12-5-3-8-16-29-18(13(2)28-21-19-20(27-11-26-19)30-23(25)31-21)17(22(33)32(12)16)15-7-4-6-14(9-15)10-24/h3-9,11,13H,1-2H3,(H4,25,26,27,28,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394315
PNG
(US9975907, Example 35)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(Cl)c1
Show InChI InChI=1/C20H16ClFN8OS/c1-8-6-32-20-27-14(9(2)26-17-15-16(25-7-24-15)28-19(23)29-17)13(18(31)30(8)20)10-3-11(21)5-12(22)4-10/h3-7,9H,1-2H3,(H4,23,24,25,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394328
PNG
(US9975907, Example 48)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(n2c(=O)c1-c1cccc(F)c1)C(F)(F)F
Show InChI InChI=1/C20H13F4N7OS/c1-9(29-17-15-16(26-7-25-15)27-8-28-17)14-13(10-3-2-4-11(21)5-10)18(32)31-12(20(22,23)24)6-33-19(31)30-14/h2-9H,1H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM394290
PNG
(US9975907, Example 9)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
Show InChI InChI=1/C20H18N8OS/c1-10-8-30-20-25-14(13(18(29)28(10)20)12-6-4-3-5-7-12)11(2)24-17-15-16(23-9-22-15)26-19(21)27-17/h3-9,11H,1-2H3,(H4,21,22,23,24,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394312
PNG
(US9975907, Example 32)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(Cl)c1
Show InChI InChI=1/C20H17ClN8OS/c1-9-7-31-20-26-14(13(18(30)29(9)20)11-4-3-5-12(21)6-11)10(2)25-17-15-16(24-8-23-15)27-19(22)28-17/h3-8,10H,1-2H3,(H4,22,23,24,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394357
PNG
(US9975907, Example 77)
Show SMILES CCc1cccc2nc(C(C)Nc3nc(N)nc4[nH]cnc34)c(-c3cc(F)cc(F)c3)c(=O)n12
Show InChI InChI=1/C23H20F2N8O/c1-3-15-5-4-6-16-30-18(11(2)29-21-19-20(28-10-27-19)31-23(26)32-21)17(22(34)33(15)16)12-7-13(24)9-14(25)8-12/h4-11H,3H2,1-2H3,(H4,26,27,28,29,31,32)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394302
PNG
(US9975907, Example 22)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccc(F)cc1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-3-5-13(21)6-4-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 75n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394285
PNG
(US9975907, Example 4)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C23H20FN7O/c1-3-16(29-22-20-21(26-11-25-20)27-12-28-22)19-18(14-7-5-8-15(24)10-14)23(32)31-13(2)6-4-9-17(31)30-19/h4-12,16H,3H2,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394306
PNG
(US9975907, Example 26)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C19H15FN8OS/c1-9(24-16-14-15(23-8-22-14)26-18(21)27-16)13-12(10-3-2-4-11(20)7-10)17(29)28-5-6-30-19(28)25-13/h2-9H,1H3,(H4,21,22,23,24,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394284
PNG
(US9975907, Example 3)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cncc(F)c1
Show InChI InChI=1/C22H19FN8O/c1-3-15(29-21-19-20(26-10-25-19)27-11-28-21)18-17(13-7-14(23)9-24-8-13)22(32)31-12(2)5-4-6-16(31)30-18/h4-11,15H,3H2,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394360
PNG
(US9975907, Example 80)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2ccccn2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C21H16F2N8O/c1-10(27-19-17-18(26-9-25-17)29-21(24)30-19)16-15(11-6-12(22)8-13(23)7-11)20(32)31-5-3-2-4-14(31)28-16/h2-10H,1H3,(H4,24,25,26,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394356
PNG
(US9975907, Example 76)
Show SMILES CCc1cccc2nc(C(C)Nc3ncnc4[nH]cnc34)c(-c3cc(F)cc(F)c3)c(=O)n12
Show InChI InChI=1/C23H19F2N7O/c1-3-16-5-4-6-17-31-19(12(2)30-22-20-21(27-10-26-20)28-11-29-22)18(23(33)32(16)17)13-7-14(24)9-15(25)8-13/h4-12H,3H2,1-2H3,(H2,26,27,28,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394342
PNG
(US9975907, Example 62)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(cc1)C#N
Show InChI InChI=1/C23H19N9O/c1-12-4-3-5-16-29-18(13(2)28-21-19-20(27-11-26-19)30-23(25)31-21)17(22(33)32(12)16)15-8-6-14(10-24)7-9-15/h3-9,11,13H,1-2H3,(H4,25,26,27,28,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394311
PNG
(US9975907, Example 31)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccc(C)cc1
Show InChI InChI=1/C21H19N7OS/c1-11-4-6-14(7-5-11)15-16(27-21-28(20(15)29)12(2)8-30-21)13(3)26-19-17-18(23-9-22-17)24-10-25-19/h4-10,13H,1-3H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394284
PNG
(US9975907, Example 3)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cncc(F)c1
Show InChI InChI=1/C22H19FN8O/c1-3-15(29-21-19-20(26-10-25-19)27-11-28-21)18-17(13-7-14(23)9-24-8-13)22(32)31-12(2)5-4-6-16(31)30-18/h4-11,15H,3H2,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394349
PNG
(US9975907, Example 69)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C22H17F2N7O/c1-11-4-3-5-16-30-18(12(2)29-21-19-20(26-9-25-19)27-10-28-21)17(22(32)31(11)16)13-6-14(23)8-15(24)7-13/h3-10,12H,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394327
PNG
(US9975907, Example 47)
Show SMILES C[C@H](Nc1nc(O)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7O2S/c1-9-7-31-20-25-14(13(18(29)28(9)20)11-4-3-5-12(21)6-11)10(2)24-17-15-16(23-8-22-15)26-19(30)27-17/h3-8,10H,1-2H3,(H3,22,23,24,26,27,30)/t10-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394317
PNG
(US9975907, Example 37)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(Cl)c1
Show InChI InChI=1/C20H15ClFN7OS/c1-9-6-31-20-28-15(10(2)27-18-16-17(24-7-23-16)25-8-26-18)14(19(30)29(9)20)11-3-12(21)5-13(22)4-11/h3-8,10H,1-2H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394299
PNG
(US9975907, Example 19)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccncc1
Show InChI InChI=1/C19H16N8OS/c1-10-7-29-19-26-14(13(18(28)27(10)19)12-3-5-20-6-4-12)11(2)25-17-15-16(22-8-21-15)23-9-24-17/h3-9,11H,1-2H3,(H2,21,22,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394298
PNG
(US9975907, Example 18)
Show SMILES CC(Nc1nc(F)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H14F3N7OS/c1-8-6-32-20-27-14(9(2)26-17-15-16(25-7-24-15)28-19(23)29-17)13(18(31)30(8)20)10-3-11(21)5-12(22)4-10/h3-7,9H,1-2H3,(H2,24,25,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394282
PNG
(US9975907, Example 1)
Show SMILES CC(c1nc2cccc(C)n2c(=O)c1-c1ccccc1)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C22H19N7O/c1-13-7-6-10-16-27-18(17(22(30)29(13)16)15-8-4-3-5-9-15)14(2)28-12-26-19-20(23)24-11-25-21(19)28/h3-12,14H,1-2H3,(H2,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394307
PNG
(US9975907, Example 27)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1ccccc1
Show InChI InChI=1/C19H16N8OS/c1-10(23-16-14-15(22-9-21-14)25-18(20)26-16)13-12(11-5-3-2-4-6-11)17(28)27-7-8-29-19(27)24-13/h2-10H,1H3,(H4,20,21,22,23,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394363
PNG
(US9975907, Example 83)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(c1)C#N
Show InChI InChI=1/C23H18N8O/c1-13-5-3-8-17-30-19(14(2)29-22-20-21(26-11-25-20)27-12-28-22)18(23(32)31(13)17)16-7-4-6-15(9-16)10-24/h3-9,11-12,14H,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394297
PNG
(US9975907, Example 17)
Show SMILES CC(Nc1ncnc2[nH]ccc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C21H16F2N6OS/c1-10-8-31-21-28-17(11(2)27-19-15-3-4-24-18(15)25-9-26-19)16(20(30)29(10)21)12-5-13(22)7-14(23)6-12/h3-9,11H,1-2H3,(H2,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394288
PNG
(US9975907, Example 7)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cn[nH]c1
Show InChI InChI=1/C20H19N9O/c1-3-13(27-19-17-18(22-9-21-17)23-10-24-19)16-15(12-7-25-26-8-12)20(30)29-11(2)5-4-6-14(29)28-16/h4-10,13H,3H2,1-2H3,(H,25,26)(H2,21,22,23,24,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394287
PNG
(US9975907, Example 6)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccnc1F
Show InChI InChI=1/C22H19FN8O/c1-3-14(29-21-18-20(26-10-25-18)27-11-28-21)17-16(13-7-5-9-24-19(13)23)22(32)31-12(2)6-4-8-15(31)30-17/h4-11,14H,3H2,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394331
PNG
(US9975907, Example 51)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(C)c1
Show InChI InChI=1/C23H21N7O/c1-13-6-4-8-16(10-13)18-19(29-17-9-5-7-14(2)30(17)23(18)31)15(3)28-22-20-21(25-11-24-20)26-12-27-22/h4-12,15H,1-3H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US9975907, Example 13 | US9975907, Example 23)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H16F2N8OS/c1-8-6-32-20-27-14(9(2)26-17-15-16(25-7-24-15)28-19(23)29-17)13(18(31)30(8)20)10-3-11(21)5-12(22)4-10/h3-7,9H,1-2H3,(H4,23,24,25,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394287
PNG
(US9975907, Example 6)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccnc1F
Show InChI InChI=1/C22H19FN8O/c1-3-14(29-21-18-20(26-10-25-18)27-11-28-21)17-16(13-7-5-9-24-19(13)23)22(32)31-12(2)6-4-8-15(31)30-17/h4-11,14H,3H2,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394282
PNG
(US9975907, Example 1)
Show SMILES CC(c1nc2cccc(C)n2c(=O)c1-c1ccccc1)n1cnc2c(N)ncnc12
Show InChI InChI=1S/C22H19N7O/c1-13-7-6-10-16-27-18(17(22(30)29(13)16)15-8-4-3-5-9-15)14(2)28-12-26-19-20(23)24-11-25-21(19)28/h3-12,14H,1-2H3,(H2,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394348
PNG
(US9975907, Example 68)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(F)c(F)c1
Show InChI InChI=1/C22H17F2N7O/c1-11-4-3-5-16-30-18(12(2)29-21-19-20(26-9-25-19)27-10-28-21)17(22(32)31(11)16)13-6-7-14(23)15(24)8-13/h3-10,12H,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM394292
PNG
(US9975907, Example 11)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H17FN8OS/c1-9-7-31-20-26-14(13(18(30)29(9)20)11-4-3-5-12(21)6-11)10(2)25-17-15-16(24-8-23-15)27-19(22)28-17/h3-8,10H,1-2H3,(H4,22,23,24,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394286
PNG
(US9975907, Example 5)
Show SMILES CCC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C23H19F2N7O/c1-3-16(30-22-20-21(27-10-26-20)28-11-29-22)19-18(13-7-14(24)9-15(25)8-13)23(33)32-12(2)5-4-6-17(32)31-19/h4-11,16H,3H2,1-2H3,(H2,26,27,28,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
PI3-Kinase luminescent assay kit including lipid kinase substrate, D-myo-phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2)D (+)-sn-1,2-di-O-octan...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394343
PNG
(US9975907, Example 63)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccccc1C
Show InChI InChI=1/C23H21N7O/c1-13-7-4-5-9-16(13)18-19(29-17-10-6-8-14(2)30(17)23(18)31)15(3)28-22-20-21(25-11-24-20)26-12-27-22/h4-12,15H,1-3H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394333
PNG
(US9975907, Example 53)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(Cl)c1
Show InChI InChI=1/C22H18ClN7O/c1-12-5-3-8-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-6-4-7-15(23)9-14/h3-11,13H,1-2H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394322
PNG
(US9975907, Example 42)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cncc(F)c1
Show InChI InChI=1/C19H15FN8OS/c1-9-6-30-19-27-14(10(2)26-17-15-16(23-7-22-15)24-8-25-17)13(18(29)28(9)19)11-3-12(20)5-21-4-11/h3-8,10H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394316
PNG
(US9975907, Example 36)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(Cl)c1
Show InChI InChI=1/C20H16ClN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 300n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM394290
PNG
(US9975907, Example 9)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
Show InChI InChI=1/C20H18N8OS/c1-10-8-30-20-25-14(13(18(29)28(10)20)12-6-4-3-5-7-12)11(2)24-17-15-16(23-9-22-15)26-19(21)27-17/h3-9,11H,1-2H3,(H4,21,22,23,24,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394355
PNG
(US9975907, Example 75)
Show SMILES C[C@H](Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C22H19FN8O/c1-11-5-3-8-15-28-17(16(21(32)31(11)15)13-6-4-7-14(23)9-13)12(2)27-20-18-19(26-10-25-18)29-22(24)30-20/h3-10,12H,1-2H3,(H4,24,25,26,27,29,30)/t12-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US9975907, Example 12 | US9975907, Example 44)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H15F2N7OS/c1-9-6-31-20-28-15(10(2)27-18-16-17(24-7-23-16)25-8-26-18)14(19(30)29(9)20)11-3-12(21)5-13(22)4-11/h3-8,10H,1-2H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM124077
PNG
(US8754089, 3-(3-fluorophenyl)-6-methyl-2-((1S)-1-(...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C22H18FN7O/c1-12-5-3-8-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-6-4-7-15(23)9-14/h3-11,13H,1-2H3,(H2,24,25,26,27,28)/t13-/m0/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394341
PNG
(US9975907, Example 61)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(cc1)C#N
Show InChI InChI=1/C23H18N8O/c1-13-4-3-5-17-30-19(14(2)29-22-20-21(26-11-25-20)27-12-28-22)18(23(32)31(13)17)16-8-6-15(10-24)7-9-16/h3-9,11-12,14H,1-2H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394309
PNG
(US9975907, Example 29)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1ccccc1
Show InChI InChI=1/C19H15N7OS/c1-11(24-17-15-16(21-9-20-15)22-10-23-17)14-13(12-5-3-2-4-6-12)18(27)26-7-8-28-19(26)25-14/h2-11H,1H3,(H2,20,21,22,23,24)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM50004547
PNG
(CHEMBL2216863 | US10065963, Compound 28 | US970833...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US9975907, Example 13 | US9975907, Example 23)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H16F2N8OS/c1-8-6-32-20-27-14(9(2)26-17-15-16(25-7-24-15)28-19(23)29-17)13(18(31)30(8)20)10-3-11(21)5-12(22)4-10/h3-7,9H,1-2H3,(H4,23,24,25,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM394292
PNG
(US9975907, Example 11)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H17FN8OS/c1-9-7-31-20-26-14(13(18(30)29(9)20)11-4-3-5-12(21)6-11)10(2)25-17-15-16(24-8-23-15)27-19(22)28-17/h3-8,10H,1-2H3,(H4,22,23,24,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM394290
PNG
(US9975907, Example 9)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1ccccc1
Show InChI InChI=1/C20H18N8OS/c1-10-8-30-20-25-14(13(18(29)28(10)20)12-6-4-3-5-7-12)11(2)24-17-15-16(23-9-22-15)26-19(21)27-17/h3-9,11H,1-2H3,(H4,21,22,23,24,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394305
PNG
(US9975907, Example 25)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C19H13F2N7OS/c1-9(26-17-15-16(23-7-22-15)24-8-25-17)14-13(10-4-11(20)6-12(21)5-10)18(29)28-2-3-30-19(28)27-14/h2-9H,1H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394308
PNG
(US9975907, Example 28)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C19H14FN7OS/c1-10(25-17-15-16(22-8-21-15)23-9-24-17)14-13(11-3-2-4-12(20)7-11)18(28)27-5-6-29-19(27)26-14/h2-10H,1H3,(H2,21,22,23,24,25)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US9975907, Example 12 | US9975907, Example 44)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H15F2N7OS/c1-9-6-31-20-28-15(10(2)27-18-16-17(24-7-23-16)25-8-26-18)14(19(30)29(9)20)11-3-12(21)5-13(22)4-11/h3-8,10H,1-2H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM50004547
PNG
(CHEMBL2216863 | US10065963, Compound 28 | US970833...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394361
PNG
(US9975907, Example 81)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cnc(Cl)c(C)c1
Show InChI InChI=1/C22H19ClN8O/c1-11-7-14(8-24-19(11)23)16-17(30-15-6-4-5-12(2)31(15)22(16)32)13(3)29-21-18-20(26-9-25-18)27-10-28-21/h4-10,13H,1-3H3,(H2,25,26,27,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394304
PNG
(US9975907, Example 24)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2sccn2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C19H14F2N8OS/c1-8(25-16-14-15(24-7-23-14)27-18(22)28-16)13-12(9-4-10(20)6-11(21)5-9)17(30)29-2-3-31-19(29)26-13/h2-8H,1H3,(H4,22,23,24,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US9975907, Example 13 | US9975907, Example 23)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H16F2N8OS/c1-8-6-32-20-27-14(9(2)26-17-15-16(25-7-24-15)28-19(23)29-17)13(18(31)30(8)20)10-3-11(21)5-12(22)4-10/h3-7,9H,1-2H3,(H4,23,24,25,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394362
PNG
(US9975907, Example 82)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cnc(Cl)c(C)c1
Show InChI InChI=1/C22H20ClN9O/c1-10-7-13(8-25-18(10)23)15-16(29-14-6-4-5-11(2)32(14)21(15)33)12(3)28-20-17-19(27-9-26-17)30-22(24)31-20/h4-9,12H,1-3H3,(H4,24,26,27,28,30,31)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM50004547
PNG
(CHEMBL2216863 | US10065963, Compound 28 | US970833...)
Show SMILES C[C@H](Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)/t11-/s2
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
CHEMBL
KEGG
PC cid
PC sid
UniChem

Patents


Similars

US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM394293
PNG
(US9975907, Example 12 | US9975907, Example 44)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H15F2N7OS/c1-9-6-31-20-28-15(10(2)27-18-16-17(24-7-23-16)25-8-26-18)14(19(30)29(9)20)11-3-12(21)5-13(22)4-11/h3-8,10H,1-2H3,(H2,23,24,25,26,27)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394336
PNG
(US9975907, Example 56)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1/C22H19ClN8O/c1-11-4-3-5-15-28-17(16(21(32)31(11)15)13-6-8-14(23)9-7-13)12(2)27-20-18-19(26-10-25-18)29-22(24)30-20/h3-10,12H,1-2H3,(H4,24,25,26,27,29,30)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM394294
PNG
(US9975907, Example 13 | US9975907, Example 23)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C20H16F2N8OS/c1-8-6-32-20-27-14(9(2)26-17-15-16(25-7-24-15)28-19(23)29-17)13(18(31)30(8)20)10-3-11(21)5-12(22)4-10/h3-7,9H,1-2H3,(H4,23,24,25,26,28,29)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394359
PNG
(US9975907, Example 79)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2ccccn2c(=O)c1-c1cc(F)cc(F)c1
Show InChI InChI=1/C21H15F2N7O/c1-11(28-20-18-19(25-9-24-18)26-10-27-20)17-16(12-6-13(22)8-14(23)7-12)21(31)30-5-3-2-4-15(30)29-17/h2-11H,1H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM394292
PNG
(US9975907, Example 11)
Show SMILES CC(Nc1nc(N)nc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H17FN8OS/c1-9-7-31-20-26-14(13(18(30)29(9)20)11-4-3-5-12(21)6-11)10(2)25-17-15-16(24-8-23-15)27-19(22)28-17/h3-8,10H,1-2H3,(H4,22,23,24,25,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform/gamma isoform


(Homo sapiens (Human))
BDBM394335
PNG
(US9975907, Example 55)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1ccc(Cl)cc1
Show InChI InChI=1/C22H18ClN7O/c1-12-4-3-5-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-6-8-15(23)9-7-14/h3-11,13H,1-2H3,(H2,24,25,26,27,28)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
The kinase reaction was conducted in polystyrene 384-well matrix white plate from Thermo Fisher Scientific in a final volume of 25 μL. Inhibitor...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM124076
PNG
(US8754089, 3-(3-fluorophenyl)-6-methyl-2-((1R)-1-(...)
Show SMILES C[C@@H](Nc1ncnc2[nH]cnc12)c1nc2cccc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1S/C22H18FN7O/c1-12-5-3-8-16-29-18(13(2)28-21-19-20(25-10-24-19)26-11-27-21)17(22(31)30(12)16)14-6-4-7-15(23)9-14/h3-11,13H,1-2H3,(H2,24,25,26,27,28)/t13-/m1/s1
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem

Similars

US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 3-kinase regulatory subunit beta/Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform


(Homo sapiens (Human))
BDBM246889
PNG
(7-(1-(9H-purin-6- ylamino)ethyl)-6-(3- fluoropheny...)
Show SMILES CC(Nc1ncnc2[nH]cnc12)c1nc2scc(C)n2c(=O)c1-c1cccc(F)c1
Show InChI InChI=1/C20H16FN7OS/c1-10-7-30-20-27-15(11(2)26-18-16-17(23-8-22-16)24-9-25-18)14(19(29)28(10)20)12-4-3-5-13(21)6-12/h3-9,11H,1-2H3,(H2,22,23,24,25,26)
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

B.MOAD
DrugBank
GoogleScholar
KEGG
PC cid
PC sid
UniChem
US Patent
n/an/a>500n/an/an/an/an/an/a



Incyte Holdings Corporation; Incyte Corporation

US Patent


Assay Description
Materials: Lipid kinase substrate, phosphoinositol-4,5-bisphosphate (PIP2), was purchased from Echelon Biosciences (Salt Lake City, Utah). PI3K isofo...


US Patent US9975907 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%