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Patent code US9980929

Compile Data Set for Download or QSAR
Found 73 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396352
PNG
(US9980929, Example 54)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccccc1)Oc1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C29H27Cl2F3N2O4/c1-17(2)24(26(37)29(32,33)34)35-28(39)25(19-11-7-4-8-12-19)36-27(38)23(13-18-9-5-3-6-10-18)40-22-15-20(30)14-21(31)16-22/h3-12,14-17,23-25H,13H2,1-2H3,(H,35,39)(H,36,38)/t23-,24+,25+/m1/s1
MMDB

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n/an/a 0.976n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396353
PNG
(US9980929, Example 55)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C(Cc1ccc(Cl)c(Cl)c1)Oc1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C29H25Cl4F3N2O4/c1-15(2)24(26(39)29(34,35)36)37-28(41)25(17-6-4-3-5-7-17)38-27(40)23(13-16-8-10-19(30)21(32)12-16)42-18-9-11-20(31)22(33)14-18/h3-12,14-15,23-25H,13H2,1-2H3,(H,37,41)(H,38,40)/t23?,24-,25-/m0/s1
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n/an/a 1.18n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396373
PNG
(US9980929, Example 75)
Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1cnccn1)Oc1cc(Cl)cc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Show InChI InChI=1S/C28H27Cl2F3N4O5/c1-15(2)23(25(38)28(31,32)33)36-27(40)24(16-4-6-20(41-3)7-5-16)37-26(39)22(13-19-14-34-8-9-35-19)42-21-11-17(29)10-18(30)12-21/h4-12,14-15,22-24H,13H2,1-3H3,(H,36,40)(H,37,39)/t22-,23-,24-/m0/s1
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n/an/a 2.88n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396359
PNG
(US9980929, Example 61)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](Cc1ccccc1)Oc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C30H29Cl2F3N2O4/c1-18(2)26(27(38)30(33,34)35)37-28(39)24(13-19-9-5-3-6-10-19)36-29(40)25(14-20-11-7-4-8-12-20)41-23-16-21(31)15-22(32)17-23/h3-12,15-18,24-26H,13-14H2,1-2H3,(H,36,40)(H,37,39)/t24-,25+,26-/m0/s1
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n/an/a 3.31n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396372
PNG
(US9980929, Example 74)
Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@@H](Cc1ccccn1)Oc1cc(Cl)cc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Show InChI InChI=1S/C29H28Cl2F3N3O5/c1-16(2)24(26(38)29(32,33)34)36-28(40)25(17-7-9-21(41-3)10-8-17)37-27(39)23(15-20-6-4-5-11-35-20)42-22-13-18(30)12-19(31)14-22/h4-14,16,23-25H,15H2,1-3H3,(H,36,40)(H,37,39)/t23-,24+,25+/m1/s1
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n/an/a 4.28n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396362
PNG
(US9980929, Example 64)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C(CC1CCCCC1)Oc1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C29H33Cl2F3N2O4/c1-17(2)24(26(37)29(32,33)34)35-28(39)25(19-11-7-4-8-12-19)36-27(38)23(13-18-9-5-3-6-10-18)40-22-15-20(30)14-21(31)16-22/h4,7-8,11-12,14-18,23-25H,3,5-6,9-10,13H2,1-2H3,(H,35,39)(H,36,38)/t23?,24-,25-/m0/s1
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n/an/a 4.47n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396361
PNG
(US9980929, Example 63)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C(Cc1ccccc1)Oc1cc(F)cc(F)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C29H27F5N2O4/c1-17(2)24(26(37)29(32,33)34)35-28(39)25(19-11-7-4-8-12-19)36-27(38)23(13-18-9-5-3-6-10-18)40-22-15-20(30)14-21(31)16-22/h3-12,14-17,23-25H,13H2,1-2H3,(H,35,39)(H,36,38)/t23?,24-,25-/m0/s1
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n/an/a 4.53n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396348
PNG
(US9980929, Example 46)
Show SMILES COc1cccc(c1)[C@H](NC(=O)CCc1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H25Cl2F3N2O4/c1-13(2)20(22(33)24(27,28)29)31-23(34)21(15-5-4-6-16(12-15)35-3)30-19(32)10-8-14-7-9-17(25)18(26)11-14/h4-7,9,11-13,20-21H,8,10H2,1-3H3,(H,30,32)(H,31,34)/t20-,21-/m0/s1
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n/an/a 6n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396367
PNG
(US9980929, Example 69)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccn1)Oc1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C28H26Cl2F3N3O4/c1-16(2)23(25(37)28(31,32)33)35-27(39)24(17-8-4-3-5-9-17)36-26(38)22(15-20-10-6-7-11-34-20)40-21-13-18(29)12-19(30)14-21/h3-14,16,22-24H,15H2,1-2H3,(H,35,39)(H,36,38)/t22-,23-,24-/m0/s1
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n/an/a 6.07n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396330
PNG
(US9980929, Example 28)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C23H21Cl2F3N2O3/c1-13(2)19(21(32)23(26,27)28)30-22(33)20(15-6-4-3-5-7-15)29-18(31)11-9-14-8-10-16(24)17(25)12-14/h3-13,19-20H,1-2H3,(H,29,31)(H,30,33)/b11-9+/t19-,20-/m0/s1
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n/an/a 9n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396349
PNG
(US9980929, Example 48)
Show SMILES COc1cccc(c1)[C@H](NC(=O)CCc1cc(Cl)cc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H25Cl2F3N2O4/c1-13(2)20(22(33)24(27,28)29)31-23(34)21(15-5-4-6-18(11-15)35-3)30-19(32)8-7-14-9-16(25)12-17(26)10-14/h4-6,9-13,20-21H,7-8H2,1-3H3,(H,30,32)(H,31,34)/t20-,21-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396350
PNG
(US9980929, Example 50)
Show SMILES COc1cccc(c1)[C@H](NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H23Cl2F3N2O4/c1-13(2)20(22(33)24(27,28)29)31-23(34)21(15-5-4-6-16(12-15)35-3)30-19(32)10-8-14-7-9-17(25)18(26)11-14/h4-13,20-21H,1-3H3,(H,30,32)(H,31,34)/b10-8+/t20-,21-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396326
PNG
(US9980929, Example 24)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(c1ccccc1)c1cccc(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C29H28ClF3N2O3/c1-18(2)25(27(37)29(31,32)33)35-28(38)26(20-12-7-4-8-13-20)34-24(36)17-23(19-10-5-3-6-11-19)21-14-9-15-22(30)16-21/h3-16,18,23,25-26H,17H2,1-2H3,(H,34,36)(H,35,38)/t23?,25-,26-/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396338
PNG
(US9980929, Example 36)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C(Oc1cc(Cl)cc(Cl)c1)c1ccccc1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C28H25Cl2F3N2O4/c1-16(2)22(25(36)28(31,32)33)34-26(37)23(17-9-5-3-6-10-17)35-27(38)24(18-11-7-4-8-12-18)39-21-14-19(29)13-20(30)15-21/h3-16,22-24H,1-2H3,(H,34,37)(H,35,38)/t22-,23-,24?/m0/s1
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n/an/a 10n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396369
PNG
(US9980929, Example 71)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cccnc1)Oc1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C28H26Cl2F3N3O4/c1-16(2)23(25(37)28(31,32)33)35-27(39)24(18-8-4-3-5-9-18)36-26(38)22(11-17-7-6-10-34-15-17)40-21-13-19(29)12-20(30)14-21/h3-10,12-16,22-24H,11H2,1-2H3,(H,35,39)(H,36,38)/t22-,23-,24-/m0/s1
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n/an/a 10.1n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396364
PNG
(US9980929, Example 66)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)C(CC1CCCCC1)Oc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C30H35Cl2F3N2O4/c1-18(2)26(27(38)30(33,34)35)37-28(39)24(13-19-9-5-3-6-10-19)36-29(40)25(14-20-11-7-4-8-12-20)41-23-16-21(31)15-22(32)17-23/h3,5-6,9-10,15-18,20,24-26H,4,7-8,11-14H2,1-2H3,(H,36,40)(H,37,39)/t24-,25?,26-/m0/s1
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n/an/a 10.6n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396325
PNG
(US9980929, Example 23)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CCc1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C23H23Cl2F3N2O3/c1-13(2)19(21(32)23(26,27)28)30-22(33)20(15-6-4-3-5-7-15)29-18(31)11-9-14-8-10-16(24)17(25)12-14/h3-8,10,12-13,19-20H,9,11H2,1-2H3,(H,29,31)(H,30,33)/t19-,20-/m0/s1
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n/an/a 15n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396321
PNG
(US9980929, Example 19)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H22Cl3F3N2O3/c1-13(2)21(22(34)24(28,29)30)32-23(35)19(12-15-4-3-5-16(25)10-15)31-20(33)9-7-14-6-8-17(26)18(27)11-14/h3-11,13,19,21H,12H2,1-2H3,(H,31,33)(H,32,35)/b9-7+/t19-,21-/m0/s1
MMDB

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n/an/a 15n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396354
PNG
(US9980929, Example 56)
Show SMILES COc1ccc(cc1)[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C30H30ClF3N2O4/c1-18(2)25(27(37)30(32,33)34)35-29(39)26(21-7-5-4-6-8-21)36-28(38)24(17-19-9-13-22(31)14-10-19)20-11-15-23(40-3)16-12-20/h4-16,18,24-26H,17H2,1-3H3,(H,35,39)(H,36,38)/t24-,25+,26+/m1/s1
MMDB

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n/an/a 15.1n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396332
PNG
(US9980929, Example 30)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CCc1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C23H22Cl3F3N2O3/c1-12(2)19(21(33)23(27,28)29)31-22(34)20(14-5-7-15(24)8-6-14)30-18(32)10-4-13-3-9-16(25)17(26)11-13/h3,5-9,11-12,19-20H,4,10H2,1-2H3,(H,30,32)(H,31,34)/t19-,20-/m0/s1
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n/an/a 20n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396331
PNG
(US9980929, Example 29)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)COc1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C22H21Cl2F3N2O4/c1-12(2)18(20(31)22(25,26)27)29-21(32)19(13-6-4-3-5-7-13)28-17(30)11-33-16-9-14(23)8-15(24)10-16/h3-10,12,18-19H,11H2,1-2H3,(H,28,30)(H,29,32)/t18-,19-/m0/s1
MMDB

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n/an/a 20n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396351
PNG
(US9980929, Example 52)
Show SMILES COc1cccc(c1)[C@H](NC(=O)CC(c1ccccc1)c1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Show InChI InChI=1S/C30H30ClF3N2O4/c1-18(2)26(28(38)30(32,33)34)36-29(39)27(21-12-8-14-23(16-21)40-3)35-25(37)17-24(19-9-5-4-6-10-19)20-11-7-13-22(31)15-20/h4-16,18,24,26-27H,17H2,1-3H3,(H,35,37)(H,36,39)/t24?,26-,27-/m0/s1
MMDB

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n/an/a 23n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396335
PNG
(US9980929, Example 33)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C23H20Cl3F3N2O3/c1-12(2)19(21(33)23(27,28)29)31-22(34)20(14-5-7-15(24)8-6-14)30-18(32)10-4-13-3-9-16(25)17(26)11-13/h3-12,19-20H,1-2H3,(H,30,32)(H,31,34)/b10-4+/t19-,20-/m0/s1
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n/an/a 25n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396340
PNG
(US9980929, Example 38)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)c1cc2cc(Cl)cc(Br)c2o1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C23H19BrClF3N2O4/c1-11(2)17(20(31)23(26,27)28)29-22(33)18(12-6-4-3-5-7-12)30-21(32)16-9-13-8-14(25)10-15(24)19(13)34-16/h3-11,17-18H,1-2H3,(H,29,33)(H,30,32)/t17-,18-/m0/s1
MMDB

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n/an/a 30n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396337
PNG
(US9980929, Example 35)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)COc1cc(Cl)cc(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C22H20Cl3F3N2O4/c1-11(2)18(20(32)22(26,27)28)30-21(33)19(12-3-5-13(23)6-4-12)29-17(31)10-34-16-8-14(24)7-15(25)9-16/h3-9,11,18-19H,10H2,1-2H3,(H,29,31)(H,30,33)/t18-,19-/m0/s1
MMDB

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n/an/a 35n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396314
PNG
(US9980929, Example 12)
Show SMILES COc1ccc(cc1)C(CC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C31H30Cl3F3N2O4/c1-17(2)28(29(41)31(35,36)37)39-30(42)26(14-18-4-9-21(32)10-5-18)38-27(40)16-23(19-6-11-22(43-3)12-7-19)20-8-13-24(33)25(34)15-20/h4-13,15,17,23,26,28H,14,16H2,1-3H3,(H,38,40)(H,39,42)/t23?,26-,28-/m0/s1
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n/an/a 35n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396306
PNG
(US9980929, Example 4)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(c1ccccc1)c1cccc(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C30H30ClF3N2O3/c1-19(2)27(28(38)30(32,33)34)36-29(39)25(16-20-10-5-3-6-11-20)35-26(37)18-24(21-12-7-4-8-13-21)22-14-9-15-23(31)17-22/h3-15,17,19,24-25,27H,16,18H2,1-2H3,(H,35,37)(H,36,39)/t24?,25-,27-/m0/s1
MMDB

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n/an/a 37n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396371
PNG
(US9980929, Example 73)
Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@H](Cc1ccccn1)Oc1cc(Cl)cc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Show InChI InChI=1S/C29H28Cl2F3N3O5/c1-16(2)24(26(38)29(32,33)34)36-28(40)25(17-7-9-21(41-3)10-8-17)37-27(39)23(15-20-6-4-5-11-35-20)42-22-13-18(30)12-19(31)14-22/h4-14,16,23-25H,15H2,1-3H3,(H,36,40)(H,37,39)/t23-,24-,25-/m0/s1
MMDB

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n/an/a 37.3n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396323
PNG
(US9980929, Example 21)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)COc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C23H22Cl3F3N2O4/c1-12(2)20(21(33)23(27,28)29)31-22(34)18(7-13-3-5-14(24)6-4-13)30-19(32)11-35-17-9-15(25)8-16(26)10-17/h3-6,8-10,12,18,20H,7,11H2,1-2H3,(H,30,32)(H,31,34)/t18-,20-/m0/s1
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n/an/a 45n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396374
PNG
(US9980929, Example 76)
Show SMILES COc1ccc(cc1)[C@H](NC(=O)[C@@H](Cc1cnccn1)Oc1cc(Cl)cc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Show InChI InChI=1S/C28H27Cl2F3N4O5/c1-15(2)23(25(38)28(31,32)33)36-27(40)24(16-4-6-20(41-3)7-5-16)37-26(39)22(13-19-14-34-8-9-35-19)42-21-11-17(29)10-18(30)12-21/h4-12,14-15,22-24H,13H2,1-3H3,(H,36,40)(H,37,39)/t22-,23+,24+/m1/s1
MMDB

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n/an/a 48.3n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396368
PNG
(US9980929, Example 70)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc1ccccn1)Oc1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C28H26Cl2F3N3O4/c1-16(2)23(25(37)28(31,32)33)35-27(39)24(17-8-4-3-5-9-17)36-26(38)22(15-20-10-6-7-11-34-20)40-21-13-18(29)12-19(30)14-21/h3-14,16,22-24H,15H2,1-2H3,(H,35,39)(H,36,38)/t22-,23+,24+/m1/s1
MMDB

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n/an/a 48.6n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396334
PNG
(US9980929, Example 32)
Show SMILES COc1ccc(OC(CC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C31H30Cl3F3N2O5/c1-17(2)28(29(41)31(35,36)37)39-30(42)25(14-18-5-4-6-20(32)13-18)38-27(40)16-26(19-7-12-23(33)24(34)15-19)44-22-10-8-21(43-3)9-11-22/h4-13,15,17,25-26,28H,14,16H2,1-3H3,(H,38,40)(H,39,42)/t25-,26?,28-/m0/s1
MMDB

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n/an/a 50n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396366
PNG
(US9980929, Example 68)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc1cnccn1)Oc1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C27H25Cl2F3N4O4/c1-15(2)22(24(37)27(30,31)32)35-26(39)23(16-6-4-3-5-7-16)36-25(38)21(13-19-14-33-8-9-34-19)40-20-11-17(28)10-18(29)12-20/h3-12,14-15,21-23H,13H2,1-2H3,(H,35,39)(H,36,38)/t21-,22+,23+/m1/s1
MMDB

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n/an/a 50.5n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396313
PNG
(US9980929, Example 11)
Show SMILES COc1ccc(OC(CC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c2cccc(Cl)c2)cc1
Show InChI InChI=1S/C31H31Cl2F3N2O5/c1-18(2)28(29(40)31(34,35)36)38-30(41)25(15-19-7-9-21(32)10-8-19)37-27(39)17-26(20-5-4-6-22(33)16-20)43-24-13-11-23(42-3)12-14-24/h4-14,16,18,25-26,28H,15,17H2,1-3H3,(H,37,39)(H,38,41)/t25-,26?,28-/m0/s1
MMDB

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n/an/a 55n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396365
PNG
(US9980929, Example 67)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1cnccn1)Oc1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C27H25Cl2F3N4O4/c1-15(2)22(24(37)27(30,31)32)35-26(39)23(16-6-4-3-5-7-16)36-25(38)21(13-19-14-33-8-9-34-19)40-20-11-17(28)10-18(29)12-20/h3-12,14-15,21-23H,13H2,1-2H3,(H,35,39)(H,36,38)/t21-,22-,23-/m0/s1
MMDB

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n/an/a 56.6n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396316
PNG
(US9980929, Example 14)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)\C=C\c1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H22Cl3F3N2O3/c1-13(2)21(22(34)24(28,29)30)32-23(35)19(12-15-3-7-16(25)8-4-15)31-20(33)10-6-14-5-9-17(26)18(27)11-14/h3-11,13,19,21H,12H2,1-2H3,(H,31,33)(H,32,35)/b10-6+/t19-,21-/m0/s1
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n/an/a 58n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396370
PNG
(US9980929, Example 72)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)[C@@H](Cc1cccnc1)Oc1cc(Cl)cc(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C28H26Cl2F3N3O4/c1-16(2)23(25(37)28(31,32)33)35-27(39)24(18-8-4-3-5-9-18)36-26(38)22(11-17-7-6-10-34-15-17)40-21-13-19(29)12-20(30)14-21/h3-10,12-16,22-24H,11H2,1-2H3,(H,35,39)(H,36,38)/t22-,23+,24+/m1/s1
MMDB

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n/an/a 58.9n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396357
PNG
(US9980929, Example 59)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C[C@@H](N1CCS(=O)(=O)CC1)c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C27H30Cl2F3N3O5S/c1-16(2)23(25(37)27(30,31)32)34-26(38)24(17-6-4-3-5-7-17)33-22(36)15-21(18-8-9-19(28)20(29)14-18)35-10-12-41(39,40)13-11-35/h3-9,14,16,21,23-24H,10-13,15H2,1-2H3,(H,33,36)(H,34,38)/t21-,23+,24+/m1/s1
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n/an/a 59n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396324
PNG
(US9980929, Example 22)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)\C=C\c1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H22Cl3F3N2O3/c1-13(2)21(22(34)24(28,29)30)32-23(35)19(11-14-3-6-16(25)7-4-14)31-20(33)8-5-15-9-17(26)12-18(27)10-15/h3-10,12-13,19,21H,11H2,1-2H3,(H,31,33)(H,32,35)/b8-5+/t19-,21-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396308
PNG
(US9980929, Example 6)
Show SMILES COc1ccc(OC(CC(=O)N[C@@H](Cc2ccccc2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C31H32ClF3N2O5/c1-19(2)28(29(39)31(33,34)35)37-30(40)25(17-20-7-5-4-6-8-20)36-27(38)18-26(21-9-11-22(32)12-10-21)42-24-15-13-23(41-3)14-16-24/h4-16,19,25-26,28H,17-18H2,1-3H3,(H,36,38)(H,37,40)/t25-,26?,28-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396342
PNG
(US9980929, Example 40)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)c1oc2c(Cl)cc(Cl)cc2c1-c1ccccc1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C29H23Cl2F3N2O4/c1-15(2)22(26(37)29(32,33)34)35-27(38)23(17-11-7-4-8-12-17)36-28(39)25-21(16-9-5-3-6-10-16)19-13-18(30)14-20(31)24(19)40-25/h3-15,22-23H,1-2H3,(H,35,38)(H,36,39)/t22-,23-/m0/s1
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n/an/a 60n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396356
PNG
(US9980929, Example 58)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)C[C@H](N1CCS(=O)(=O)CC1)c1ccc(Cl)c(Cl)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C27H30Cl2F3N3O5S/c1-16(2)23(25(37)27(30,31)32)34-26(38)24(17-6-4-3-5-7-17)33-22(36)15-21(18-8-9-19(28)20(29)14-18)35-10-12-41(39,40)13-11-35/h3-9,14,16,21,23-24H,10-13,15H2,1-2H3,(H,33,36)(H,34,38)/t21-,23-,24-/m0/s1
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n/an/a 60.2n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396333
PNG
(US9980929, Example 31)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(c1ccccc1)c1cccc(Cl)c1)c1ccc(Cl)cc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C29H27Cl2F3N2O3/c1-17(2)25(27(38)29(32,33)34)36-28(39)26(19-11-13-21(30)14-12-19)35-24(37)16-23(18-7-4-3-5-8-18)20-9-6-10-22(31)15-20/h3-15,17,23,25-26H,16H2,1-2H3,(H,35,37)(H,36,39)/t23?,25-,26-/m0/s1
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n/an/a 65n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396347
PNG
(US9980929, Example 45)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CC(c1ccccc1)c1cccc(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C31H32ClF3N2O3/c1-20(2)28(29(39)31(33,34)35)37-30(40)26(17-16-21-10-5-3-6-11-21)36-27(38)19-25(22-12-7-4-8-13-22)23-14-9-15-24(32)18-23/h3-15,18,20,25-26,28H,16-17,19H2,1-2H3,(H,36,38)(H,37,40)/t25?,26-,28-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396336
PNG
(US9980929, Example 34)
Show SMILES COc1ccc(cc1)C(Cc1ccc(Cl)cc1)C(=O)N[C@@H](Cc1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Show InChI InChI=1S/C31H31Cl2F3N2O4/c1-18(2)27(28(39)31(34,35)36)38-30(41)26(17-20-5-4-6-23(33)15-20)37-29(40)25(16-19-7-11-22(32)12-8-19)21-9-13-24(42-3)14-10-21/h4-15,18,25-27H,16-17H2,1-3H3,(H,37,40)(H,38,41)/t25?,26-,27-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396319
PNG
(US9980929, Example 17)
Show SMILES COc1ccc(cc1)C(CC(=O)N[C@@H](Cc1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H31Cl2F3N2O4/c1-18(2)28(29(40)31(34,35)36)38-30(41)26(16-19-5-4-6-23(33)15-19)37-27(39)17-25(20-7-11-22(32)12-8-20)21-9-13-24(42-3)14-10-21/h4-15,18,25-26,28H,16-17H2,1-3H3,(H,37,39)(H,38,41)/t25?,26-,28-/m0/s1
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n/an/a 70n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396355
PNG
(US9980929, Example 57)
Show SMILES COc1ccc(cc1)[C@H](Cc1ccc(Cl)cc1)C(=O)N[C@H](C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c1ccccc1
Show InChI InChI=1S/C30H30ClF3N2O4/c1-18(2)25(27(37)30(32,33)34)35-29(39)26(21-7-5-4-6-8-21)36-28(38)24(17-19-9-13-22(31)14-10-19)20-11-15-23(40-3)16-12-20/h4-16,18,24-26H,17H2,1-3H3,(H,35,39)(H,36,38)/t24-,25-,26-/m0/s1
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n/an/a 77.8n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396311
PNG
(US9980929, Example 9)
Show SMILES COc1ccc(cc1)C(CC(=O)N[C@@H](Cc1ccc(Cl)cc1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C31H31Cl2F3N2O4/c1-18(2)28(29(40)31(34,35)36)38-30(41)26(16-19-4-10-22(32)11-5-19)37-27(39)17-25(20-6-12-23(33)13-7-20)21-8-14-24(42-3)15-9-21/h4-15,18,25-26,28H,16-17H2,1-3H3,(H,37,39)(H,38,41)/t25?,26-,28-/m0/s1
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n/an/a 80n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396341
PNG
(US9980929, Example 39)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CCC1CCCCC1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C23H31F3N2O3/c1-15(2)19(21(30)23(24,25)26)28-22(31)20(17-11-7-4-8-12-17)27-18(29)14-13-16-9-5-3-6-10-16/h4,7-8,11-12,15-16,19-20H,3,5-6,9-10,13-14H2,1-2H3,(H,27,29)(H,28,31)/t19-,20-/m0/s1
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Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396318
PNG
(US9980929, Example 16)
Show SMILES COc1ccc(cc1)C(CC(=O)N[C@@H](Cc1cccc(Cl)c1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C31H30Cl3F3N2O4/c1-17(2)28(29(41)31(35,36)37)39-30(42)26(14-18-5-4-6-21(32)13-18)38-27(40)16-23(19-7-10-22(43-3)11-8-19)20-9-12-24(33)25(34)15-20/h4-13,15,17,23,26,28H,14,16H2,1-3H3,(H,38,40)(H,39,42)/t23?,26-,28-/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396320
PNG
(US9980929, Example 18)
Show SMILES COc1ccc(OC(CC(=O)N[C@@H](Cc2cccc(Cl)c2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C31H31Cl2F3N2O5/c1-18(2)28(29(40)31(34,35)36)38-30(41)25(16-19-5-4-6-22(33)15-19)37-27(39)17-26(20-7-9-21(32)10-8-20)43-24-13-11-23(42-3)12-14-24/h4-15,18,25-26,28H,16-17H2,1-3H3,(H,37,39)(H,38,41)/t25-,26?,28-/m0/s1
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n/an/a 90n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396303
PNG
((2S)-2-[3-(3,4-Dichlorophenyl)propanoylamino]-3-ph...)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H25Cl2F3N2O3/c1-14(2)21(22(33)24(27,28)29)31-23(34)19(13-15-6-4-3-5-7-15)30-20(32)11-9-16-8-10-17(25)18(26)12-16/h3-8,10,12,14,19,21H,9,11,13H2,1-2H3,(H,30,32)(H,31,34)/t19-,21-/m0/s1
MMDB

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n/an/a 100n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396305
PNG
(US9980929, Example 3)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C23H23Cl2F3N2O4/c1-13(2)20(21(32)23(26,27)28)30-22(33)18(10-14-6-4-3-5-7-14)29-19(31)12-34-15-8-9-16(24)17(25)11-15/h3-9,11,13,18,20H,10,12H2,1-2H3,(H,29,31)(H,30,33)/t18-,20-/m0/s1
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n/an/a 110n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396310
PNG
(US9980929, Example 8)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)\C=C\c1ccc(Cl)cc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H24ClF3N2O3/c1-15(2)21(22(32)24(26,27)28)30-23(33)19(14-17-6-4-3-5-7-17)29-20(31)13-10-16-8-11-18(25)12-9-16/h3-13,15,19,21H,14H2,1-2H3,(H,29,31)(H,30,33)/b13-10+/t19-,21-/m0/s1
MMDB

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n/an/a 125n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396346
PNG
(US9980929, Example 44)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CCc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C25H27Cl2F3N2O3/c1-15(2)22(23(34)25(28,29)30)32-24(35)20(12-9-16-6-4-3-5-7-16)31-21(33)13-10-17-8-11-18(26)19(27)14-17/h3-8,11,14-15,20,22H,9-10,12-13H2,1-2H3,(H,31,33)(H,32,35)/t20-,22-/m0/s1
MMDB

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n/an/a 130n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396339
PNG
(US9980929, Example 37)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)c1oc2cc(Cl)ccc2c1-c1ccccc1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C29H24ClF3N2O4/c1-16(2)23(26(36)29(31,32)33)34-27(37)24(18-11-7-4-8-12-18)35-28(38)25-22(17-9-5-3-6-10-17)20-14-13-19(30)15-21(20)39-25/h3-16,23-24H,1-2H3,(H,34,37)(H,35,38)/t23-,24-/m0/s1
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n/an/a 130n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396312
PNG
(US9980929, Example 10)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccc(Cl)cc1)NC(=O)CC(c1ccccc1)c1ccc(Cl)cc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C30H29Cl2F3N2O3/c1-18(2)27(28(39)30(33,34)35)37-29(40)25(16-19-8-12-22(31)13-9-19)36-26(38)17-24(20-6-4-3-5-7-20)21-10-14-23(32)15-11-21/h3-15,18,24-25,27H,16-17H2,1-2H3,(H,36,38)(H,37,40)/t24?,25-,27-/m0/s1
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n/an/a 135n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396322
PNG
(US9980929, Example 20)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)CCc1cc(Cl)cc(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H24Cl3F3N2O3/c1-13(2)21(22(34)24(28,29)30)32-23(35)19(11-14-4-3-5-16(25)8-14)31-20(33)7-6-15-9-17(26)12-18(27)10-15/h3-5,8-10,12-13,19,21H,6-7,11H2,1-2H3,(H,31,33)(H,32,35)/t19-,21-/m0/s1
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n/an/a 140n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396304
PNG
(US9980929, Example 2)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)COc1cccc(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C23H24ClF3N2O4/c1-14(2)20(21(31)23(25,26)27)29-22(32)18(11-15-7-4-3-5-8-15)28-19(30)13-33-17-10-6-9-16(24)12-17/h3-10,12,14,18,20H,11,13H2,1-2H3,(H,28,30)(H,29,32)/t18-,20-/m0/s1
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n/an/a 193n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396309
PNG
(US9980929, Example 7)
Show SMILES COc1ccc(OC(CC(=O)N[C@@H](Cc2ccc(Cl)cc2)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C31H31Cl2F3N2O5/c1-18(2)28(29(40)31(34,35)36)38-30(41)25(16-19-4-8-21(32)9-5-19)37-27(39)17-26(20-6-10-22(33)11-7-20)43-24-14-12-23(42-3)13-15-24/h4-15,18,25-26,28H,16-17H2,1-3H3,(H,37,39)(H,38,41)/t25-,26?,28-/m0/s1
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n/an/a 210n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396343
PNG
(US9980929, Example 41)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC1C2C[C@@H]3C[C@@H](C[C@H]1C3)C2)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C26H33F3N2O3/c1-14(2)22(24(33)26(27,28)29)31-25(34)23(17-6-4-3-5-7-17)30-21(32)13-20-18-9-15-8-16(11-18)12-19(20)10-15/h3-7,14-16,18-20,22-23H,8-13H2,1-2H3,(H,30,32)(H,31,34)/t15-,16+,18-,19?,20?,22-,23-/m0/s1
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n/an/a 210n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396360
PNG
(US9980929, Example 62)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CCc1cc(F)cc(F)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C23H23F5N2O3/c1-13(2)19(21(32)23(26,27)28)30-22(33)20(15-6-4-3-5-7-15)29-18(31)9-8-14-10-16(24)12-17(25)11-14/h3-7,10-13,19-20H,8-9H2,1-2H3,(H,29,31)(H,30,33)/t19-,20-/m0/s1
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n/an/a 218n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396317
PNG
(US9980929, Example 15)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)CCc1ccc(Cl)c(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H24Cl3F3N2O3/c1-13(2)21(22(34)24(28,29)30)32-23(35)19(12-15-4-3-5-16(25)10-15)31-20(33)9-7-14-6-8-17(26)18(27)11-14/h3-6,8,10-11,13,19,21H,7,9,12H2,1-2H3,(H,31,33)(H,32,35)/t19-,21-/m0/s1
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n/an/a 225n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396375
PNG
(US9980929, Example 77)
Show SMILES COc1ccc(cc1)[C@H](NC(=O)COc1cccc(c1)C#N)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H24F3N3O5/c1-14(2)20(22(32)24(25,26)27)30-23(33)21(16-7-9-17(34-3)10-8-16)29-19(31)13-35-18-6-4-5-15(11-18)12-28/h4-11,14,20-21H,13H2,1-3H3,(H,29,31)(H,30,33)/t20-,21-/m0/s1
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n/an/a 345n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396363
PNG
(US9980929, Example 65)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)COc1cc(F)cc(F)c1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C22H21F5N2O4/c1-12(2)18(20(31)22(25,26)27)29-21(32)19(13-6-4-3-5-7-13)28-17(30)11-33-16-9-14(23)8-15(24)10-16/h3-10,12,18-19H,11H2,1-2H3,(H,28,30)(H,29,32)/t18-,19-/m0/s1
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n/an/a 494n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396358
PNG
(US9980929, Example 60)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CCc1cc(F)cc(F)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H25F5N2O3/c1-14(2)21(22(33)24(27,28)29)31-23(34)19(12-15-6-4-3-5-7-15)30-20(32)9-8-16-10-17(25)13-18(26)11-16/h3-7,10-11,13-14,19,21H,8-9,12H2,1-2H3,(H,30,32)(H,31,34)/t19-,21-/m0/s1
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n/an/a 650n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396329
PNG
(US9980929, Example 27)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1cccc(Cl)c1)NC(=O)c1csc2ccc(Cl)cc12)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H21Cl2F3N2O3S/c1-12(2)20(21(32)24(27,28)29)31-23(34)18(9-13-4-3-5-14(25)8-13)30-22(33)17-11-35-19-7-6-15(26)10-16(17)19/h3-8,10-12,18,20H,9H2,1-2H3,(H,30,33)(H,31,34)/t18-,20-/m0/s1
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n/an/a 770n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396345
PNG
(US9980929, Example 43)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CC(c1ccccc1)c1cccc(Cl)c1)[C@@H](C)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C31H32ClF3N2O3/c1-19(2)27(29(39)31(33,34)35)37-30(40)28(20(3)21-11-6-4-7-12-21)36-26(38)18-25(22-13-8-5-9-14-22)23-15-10-16-24(32)17-23/h4-17,19-20,25,27-28H,18H2,1-3H3,(H,36,38)(H,37,40)/t20-,25?,27-,28-/m0/s1
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n/an/a 940n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396307
PNG
(US9980929, Example 5)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CC(c1ccccc1)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C30H31F3N2O3/c1-20(2)27(28(37)30(31,32)33)35-29(38)25(18-21-12-6-3-7-13-21)34-26(36)19-24(22-14-8-4-9-15-22)23-16-10-5-11-17-23/h3-17,20,24-25,27H,18-19H2,1-2H3,(H,34,36)(H,35,38)/t25-,27-/m0/s1
MMDB

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n/an/a 1.10E+3n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396315
PNG
(US9980929, Example 13)
Show SMILES COc1ccc(cc1)C(CC(=O)N[C@@H](Cc1ccccn1)C(=O)N[C@@H](C(C)C)C(=O)C(F)(F)F)c1ccc(Cl)cc1
Show InChI InChI=1S/C30H31ClF3N3O4/c1-18(2)27(28(39)30(32,33)34)37-29(40)25(16-22-6-4-5-15-35-22)36-26(38)17-24(19-7-11-21(31)12-8-19)20-9-13-23(41-3)14-10-20/h4-15,18,24-25,27H,16-17H2,1-3H3,(H,36,38)(H,37,40)/t24?,25-,27-/m0/s1
MMDB

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n/an/a 1.56E+3n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396328
PNG
(US9980929, Example 26)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)N(C)C(=O)CC(c1ccccc1)c1cccc(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C31H32ClF3N2O3/c1-20(2)28(29(39)31(33,34)35)36-30(40)26(17-21-11-6-4-7-12-21)37(3)27(38)19-25(22-13-8-5-9-14-22)23-15-10-16-24(32)18-23/h4-16,18,20,25-26,28H,17,19H2,1-3H3,(H,36,40)/t25?,26-,28-/m0/s1
MMDB

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n/an/a 2.54E+3n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396327
PNG
(US9980929, Example 25)
Show SMILES CC(C)[C@H](NC(=O)[C@H](Cc1ccccc1)N(C)C(=O)COc1cccc(Cl)c1)C(=O)C(F)(F)F
Show InChI InChI=1S/C24H26ClF3N2O4/c1-15(2)21(22(32)24(26,27)28)29-23(33)19(12-16-8-5-4-6-9-16)30(3)20(31)14-34-18-11-7-10-17(25)13-18/h4-11,13,15,19,21H,12,14H2,1-3H3,(H,29,33)/t19-,21-/m0/s1
MMDB

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n/an/a 3.10E+3n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
Serine protease HTRA1


(Homo sapiens (Human))
BDBM396344
PNG
(US9980929, Example 42)
Show SMILES CC(C)[C@H](NC(=O)[C@@H](NC(=O)CCc1ccc(Cl)c(Cl)c1)[C@@H](C)c1ccccc1)C(=O)C(F)(F)F
Show InChI InChI=1S/C25H27Cl2F3N2O3/c1-14(2)21(23(34)25(28,29)30)32-24(35)22(15(3)17-7-5-4-6-8-17)31-20(33)12-10-16-9-11-18(26)19(27)13-16/h4-9,11,13-15,21-22H,10,12H2,1-3H3,(H,31,33)(H,32,35)/t15-,21-,22-/m0/s1
MMDB

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n/an/a 3.45E+3n/an/an/an/an/an/a



Hoffman-La Roche Inc.

US Patent


Assay Description
Enzyme activity is measured by observing the increase in fluorescence intensity caused by cleavage of a peptide substrate containing a fluorophore, w...


US Patent US9980929 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%