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Patent code US9981925

Compile Data Set for Download or QSAR
Found 150 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369774
PNG
(US10233160, Compound 65 | US9981925, Compound 65)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cccc(Br)c1
Show InChI InChI=1/C17H17BrN6O/c1-20-8-13(10-3-2-4-11(18)7-10)24-17-15-14(22-9-23-17)12(16(19)25)5-6-21-15/h2-7,9,13,20H,8H2,1H3,(H2,19,25)(H,22,23,24)/t13-/s2
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US Patent
n/an/a<25n/an/an/an/an/an/a



Merck Patent GmbH

US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369722
PNG
(US10233160, Compound 12 | US9981925, Compound 12)
Show SMILES NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(F)c(c3)C(F)(F)F)nnnc12
Show InChI InChI=1/C20H18F4N6O/c21-15-6-5-11(9-14(15)20(22,23)24)16(10-30-7-2-8-30)26-19-13-4-1-3-12(18(25)31)17(13)27-29-28-19/h1,3-6,9,16H,2,7-8,10H2,(H2,25,31)(H,26,27,28)/t16-/s2
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Merck Patent GmbH

US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369725
PNG
(US10233160, Compound 15 | US9981925, Compound 15)
Show SMILES CN(C)C[C@@H](Nc1nnnc2c(cccc12)C(N)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C18H18Cl2N6O/c1-26(2)9-15(10-6-7-13(19)14(20)8-10)22-18-12-5-3-4-11(17(21)27)16(12)23-25-24-18/h3-8,15H,9H2,1-2H3,(H2,21,27)(H,22,23,24)/t15-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369732
PNG
(US10233160, Compound 22 | US9981925, Compound 22)
Show SMILES NC(=O)c1cccc2c(NC3CNCCC3c3ccc(cc3)C(F)(F)F)nnnc12
Show InChI InChI=1/C20H19F3N6O/c21-20(22,23)12-6-4-11(5-7-12)13-8-9-25-10-16(13)26-19-15-3-1-2-14(18(24)30)17(15)27-29-28-19/h1-7,13,16,25H,8-10H2,(H2,24,30)(H,26,27,28)
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369745
PNG
(US10233160, Compound 36 | US9981925, Compound 36)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(Cl)cc3)ncnc12
Show InChI InChI=1/C19H19ClN6O/c20-13-4-2-12(3-5-13)15(10-26-8-1-9-26)25-19-17-16(23-11-24-19)14(18(21)27)6-7-22-17/h2-7,11,15H,1,8-10H2,(H2,21,27)(H,23,24,25)/t15-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369755
PNG
(US10233160, Compound 46 | US9981925, Compound 46)
Show SMILES Cc1cc(ccc1Cl)[C@@H](CN1CCC1)Nc1ncnc2c(ccnc12)C(N)=O
Show InChI InChI=1/C20H21ClN6O/c1-12-9-13(3-4-15(12)21)16(10-27-7-2-8-27)26-20-18-17(24-11-25-20)14(19(22)28)5-6-23-18/h3-6,9,11,16H,2,7-8,10H2,1H3,(H2,22,28)(H,24,25,26)/t16-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369767
PNG
(US10233160, Compound 58 | US9981925, Compound 58)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)c(F)cc1F
Show InChI InChI=1/C18H17F3N6O/c1-2-23-7-14(10-5-12(20)13(21)6-11(10)19)27-18-16-15(25-8-26-18)9(17(22)28)3-4-24-16/h3-6,8,14,23H,2,7H2,1H3,(H2,22,28)(H,25,26,27)/t14-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369767
PNG
(US10233160, Compound 58 | US9981925, Compound 58)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)c(F)cc1F
Show InChI InChI=1/C18H17F3N6O/c1-2-23-7-14(10-5-12(20)13(21)6-11(10)19)27-18-16-15(25-8-26-18)9(17(22)28)3-4-24-16/h3-6,8,14,23H,2,7H2,1H3,(H2,22,28)(H,25,26,27)/t14-/s2
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Merck Patent GmbH

US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369772
PNG
(US10233160, Compound 63 | US9981925, Compound 63)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(c(c3)C(F)(F)F)C(F)(F)F)ncnc12
Show InChI InChI=1/C21H18F6N6O/c22-20(23,24)13-3-2-11(8-14(13)21(25,26)27)15(9-33-6-1-7-33)32-19-17-16(30-10-31-19)12(18(28)34)4-5-29-17/h2-5,8,10,15H,1,6-7,9H2,(H2,28,34)(H,30,31,32)/t15-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369774
PNG
(US10233160, Compound 65 | US9981925, Compound 65)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cccc(Br)c1
Show InChI InChI=1/C17H17BrN6O/c1-20-8-13(10-3-2-4-11(18)7-10)24-17-15-14(22-9-23-17)12(16(19)25)5-6-21-15/h2-7,9,13,20H,8H2,1H3,(H2,19,25)(H,22,23,24)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369775
PNG
(US10233160, Compound 66 | US9981925, Compound 66)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cccc(F)c1
Show InChI InChI=1/C17H17FN6O/c1-20-8-13(10-3-2-4-11(18)7-10)24-17-15-14(22-9-23-17)12(16(19)25)5-6-21-15/h2-7,9,13,20H,8H2,1H3,(H2,19,25)(H,22,23,24)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369749
PNG
(US10233160, Compound 40 | US9981925, Compound 40)
Show SMILES CNC[C@@H](Nc1ncnc2c(nccc12)C(N)=O)c1ccc(cc1)C(C)C
Show InChI InChI=1/C20H24N6O/c1-12(2)13-4-6-14(7-5-13)16(10-22-3)26-20-15-8-9-23-18(19(21)27)17(15)24-11-25-20/h4-9,11-12,16,22H,10H2,1-3H3,(H2,21,27)(H,24,25,26)/t16-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369751
PNG
(US10233160, Compound 42 | US9981925, Compound 42)
Show SMILES CNC[C@@H](Nc1ncnc2c(nccc12)C(N)=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1/C18H16ClF3N6O/c1-24-7-13(9-2-3-12(19)11(6-9)18(20,21)22)28-17-10-4-5-25-15(16(23)29)14(10)26-8-27-17/h2-6,8,13,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369751
PNG
(US10233160, Compound 42 | US9981925, Compound 42)
Show SMILES CNC[C@@H](Nc1ncnc2c(nccc12)C(N)=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1/C18H16ClF3N6O/c1-24-7-13(9-2-3-12(19)11(6-9)18(20,21)22)28-17-10-4-5-25-15(16(23)29)14(10)26-8-27-17/h2-6,8,13,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369753
PNG
(US10233160, Compound 44 | US9981925, Compound 44)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(C)c1
Show InChI InChI=1/C18H19ClN6O/c1-10-7-11(3-4-13(10)19)14(8-21-2)25-18-16-15(23-9-24-18)12(17(20)26)5-6-22-16/h3-7,9,14,21H,8H2,1-2H3,(H2,20,26)(H,23,24,25)/t14-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369769
PNG
(US10233160, Compound 60 | US9981925, Compound 60)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)c(F)cc1F
Show InChI InChI=1/C17H15F3N6O/c1-22-6-13(9-4-11(19)12(20)5-10(9)18)26-17-15-14(24-7-25-17)8(16(21)27)2-3-23-15/h2-5,7,13,22H,6H2,1H3,(H2,21,27)(H,24,25,26)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369770
PNG
(US10233160, Compound 61 | US9981925, Compound 61)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1/C18H18ClFN6O/c1-2-22-8-14(10-3-4-13(20)12(19)7-10)26-18-16-15(24-9-25-18)11(17(21)27)5-6-23-16/h3-7,9,14,22H,2,8H2,1H3,(H2,21,27)(H,24,25,26)/t14-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369772
PNG
(US10233160, Compound 63 | US9981925, Compound 63)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(c(c3)C(F)(F)F)C(F)(F)F)ncnc12
Show InChI InChI=1/C21H18F6N6O/c22-20(23,24)13-3-2-11(8-14(13)21(25,26)27)15(9-33-6-1-7-33)32-19-17-16(30-10-31-19)12(18(28)34)4-5-29-17/h2-5,8,10,15H,1,6-7,9H2,(H2,28,34)(H,30,31,32)/t15-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369773
PNG
(US10233160, Compound 64 | US9981925, Compound 64)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cccc(Cl)c1
Show InChI InChI=1/C17H17ClN6O/c1-20-8-13(10-3-2-4-11(18)7-10)24-17-15-14(22-9-23-17)12(16(19)25)5-6-21-15/h2-7,9,13,20H,8H2,1H3,(H2,19,25)(H,22,23,24)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369775
PNG
(US10233160, Compound 66 | US9981925, Compound 66)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cccc(F)c1
Show InChI InChI=1/C17H17FN6O/c1-20-8-13(10-3-2-4-11(18)7-10)24-17-15-14(22-9-23-17)12(16(19)25)5-6-21-15/h2-7,9,13,20H,8H2,1H3,(H2,19,25)(H,22,23,24)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM396739
PNG
(US9981925, Compound 73)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(OC(F)(F)F)c1
Show InChI InChI=1S/C18H16ClF3N6O2/c1-24-7-12(9-2-3-11(19)13(6-9)30-18(20,21)22)28-17-15-14(26-8-27-17)10(16(23)29)4-5-25-15/h2-6,8,12,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t12-/m1/s1
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369724
PNG
(US10233160, Compound 14 | US9981925, Compound 14)
Show SMILES NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(c3)C(F)(F)F)nnnc12
Show InChI InChI=1/C20H18ClF3N6O/c21-15-6-5-11(9-14(15)20(22,23)24)16(10-30-7-2-8-30)26-19-13-4-1-3-12(18(25)31)17(13)27-29-28-19/h1,3-6,9,16H,2,7-8,10H2,(H2,25,31)(H,26,27,28)/t16-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369725
PNG
(US10233160, Compound 15 | US9981925, Compound 15)
Show SMILES CN(C)C[C@@H](Nc1nnnc2c(cccc12)C(N)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C18H18Cl2N6O/c1-26(2)9-15(10-6-7-13(19)14(20)8-10)22-18-12-5-3-4-11(17(21)27)16(12)23-25-24-18/h3-8,15H,9H2,1-2H3,(H2,21,27)(H,22,23,24)/t15-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369726
PNG
(US10233160, Compound 16 | US9981925, Compound 16)
Show SMILES NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(Cl)c3)nnnc12
Show InChI InChI=1/C19H18Cl2N6O/c20-14-6-5-11(9-15(14)21)16(10-27-7-2-8-27)23-19-13-4-1-3-12(18(22)28)17(13)24-26-25-19/h1,3-6,9,16H,2,7-8,10H2,(H2,22,28)(H,23,24,25)/t16-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369731
PNG
(US10233160, Compound 21 | US9981925, Compound 21)
Show SMILES NC(=O)c1cccc2c(NC3CNCCC3c3cccc(c3)C(F)(F)F)nnnc12
Show InChI InChI=1/C20H19F3N6O/c21-20(22,23)12-4-1-3-11(9-12)13-7-8-25-10-16(13)26-19-15-6-2-5-14(18(24)30)17(15)27-29-28-19/h1-6,9,13,16,25H,7-8,10H2,(H2,24,30)(H,26,27,28)
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369734
PNG
(US10233160, Compound 25 | US9981925, Compound 25)
Show SMILES NC(=O)c1ccnc2c(NC3CNCCC3c3ccc(cc3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H19F3N6O/c21-20(22,23)12-3-1-11(2-4-12)13-5-7-25-9-15(13)29-19-17-16(27-10-28-19)14(18(24)30)6-8-26-17/h1-4,6,8,10,13,15,25H,5,7,9H2,(H2,24,30)(H,27,28,29)
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369736
PNG
(US10233160, Compound 27 | US9981925, Compound 27)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(cc3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H19F3N6O/c21-20(22,23)13-4-2-12(3-5-13)15(10-29-8-1-9-29)28-19-17-16(26-11-27-19)14(18(24)30)6-7-25-17/h2-7,11,15H,1,8-10H2,(H2,24,30)(H,26,27,28)/t15-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369737
PNG
(US10233160, Compound 28 | US9981925, Compound 28)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(Br)c1
Show InChI InChI=1/C17H16BrFN6O/c1-21-7-13(9-2-3-12(19)11(18)6-9)25-17-15-14(23-8-24-17)10(16(20)26)4-5-22-15/h2-6,8,13,21H,7H2,1H3,(H2,20,26)(H,23,24,25)/t13-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369743
PNG
(US10233160, Compound 34 | US9981925, Compound 34)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1/C19H18F4N6O/c1-2-25-8-14(10-5-11(19(21,22)23)7-12(20)6-10)29-18-16-15(27-9-28-18)13(17(24)30)3-4-26-16/h3-7,9,14,25H,2,8H2,1H3,(H2,24,30)(H,27,28,29)/t14-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369749
PNG
(US10233160, Compound 40 | US9981925, Compound 40)
Show SMILES CNC[C@@H](Nc1ncnc2c(nccc12)C(N)=O)c1ccc(cc1)C(C)C
Show InChI InChI=1/C20H24N6O/c1-12(2)13-4-6-14(7-5-13)16(10-22-3)26-20-15-8-9-23-18(19(21)27)17(15)24-11-25-20/h4-9,11-12,16,22H,10H2,1-3H3,(H2,21,27)(H,24,25,26)/t16-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369755
PNG
(US10233160, Compound 46 | US9981925, Compound 46)
Show SMILES Cc1cc(ccc1Cl)[C@@H](CN1CCC1)Nc1ncnc2c(ccnc12)C(N)=O
Show InChI InChI=1/C20H21ClN6O/c1-12-9-13(3-4-15(12)21)16(10-27-7-2-8-27)26-20-18-17(24-11-25-20)14(19(22)28)5-6-23-18/h3-6,9,11,16H,2,7-8,10H2,1H3,(H2,22,28)(H,24,25,26)/t16-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369778
PNG
(US10233160, Compound 69 | US9981925, Compound 69)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CC(F)C3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H17ClF4N6O/c21-14-2-1-10(5-13(14)20(23,24)25)15(8-31-6-11(22)7-31)30-19-17-16(28-9-29-19)12(18(26)32)3-4-27-17/h1-5,9,11,15H,6-8H2,(H2,26,32)(H,28,29,30)/t15-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369783
PNG
(US10233160, Compound 74 | US9981925, Compound 74)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(OC(F)(F)F)c(Cl)c1
Show InChI InChI=1/C18H16ClF3N6O2/c1-24-7-12(9-2-3-13(11(19)6-9)30-18(20,21)22)28-17-15-14(26-8-27-17)10(16(23)29)4-5-25-15/h2-6,8,12,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t12-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369783
PNG
(US10233160, Compound 74 | US9981925, Compound 74)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(OC(F)(F)F)c(Cl)c1
Show InChI InChI=1/C18H16ClF3N6O2/c1-24-7-12(9-2-3-13(11(19)6-9)30-18(20,21)22)28-17-15-14(26-8-27-17)10(16(23)29)4-5-25-15/h2-6,8,12,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t12-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369784
PNG
(US10233160, Compound 75 | US9981925, Compound 75)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C17H16Cl2N6O/c1-21-7-13(9-2-3-11(18)12(19)6-9)25-17-15-14(23-8-24-17)10(16(20)26)4-5-22-15/h2-6,8,13,21H,7H2,1H3,(H2,20,26)(H,23,24,25)/t13-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369730
PNG
(US10233160, Compound 20 | US9981925, Compound 20)
Show SMILES NC(=O)c1cncc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18ClF3N6O/c21-15-3-2-11(6-14(15)20(22,23)24)16(9-30-4-1-5-30)29-19-13-8-26-7-12(18(25)31)17(13)27-10-28-19/h2-3,6-8,10,16H,1,4-5,9H2,(H2,25,31)(H,27,28,29)/t16-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369740
PNG
(US10233160, Compound 31 | US9981925, Compound 31)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)c(OC)cc1F
Show InChI InChI=1/C19H20F2N6O2/c1-3-23-8-14(11-6-13(21)15(29-2)7-12(11)20)27-19-17-16(25-9-26-19)10(18(22)28)4-5-24-17/h4-7,9,14,23H,3,8H2,1-2H3,(H2,22,28)(H,25,26,27)/t14-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369750
PNG
(US10233160, Compound 41 | US9981925, Compound 71)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18ClF3N6O/c21-14-3-2-11(8-13(14)20(22,23)24)15(9-30-6-1-7-30)29-19-17-16(27-10-28-19)12(18(25)31)4-5-26-17/h2-5,8,10,15H,1,6-7,9H2,(H2,25,31)(H,27,28,29)/t15-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM396709
PNG
(US9981925, Compound 43)
Show SMILES CNC[C@@H](Nc1ncnc2c(nccc12)C(N)=O)c1ccc(c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H16F6N6O/c1-27-7-13(9-2-3-11(18(20,21)22)12(6-9)19(23,24)25)31-17-10-4-5-28-15(16(26)32)14(10)29-8-30-17/h2-6,8,13,27H,7H2,1H3,(H2,26,32)(H,29,30,31)/t13-/m1/s1
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369756
PNG
(US10233160, Compound 47 | US9981925, Compound 47)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(C#N)c(Cl)c3)ncnc12
Show InChI InChI=1/C20H18ClN7O/c21-15-8-12(2-3-13(15)9-22)16(10-28-6-1-7-28)27-20-18-17(25-11-26-20)14(19(23)29)4-5-24-18/h2-5,8,11,16H,1,6-7,10H2,(H2,23,29)(H,25,26,27)/t16-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369756
PNG
(US10233160, Compound 47 | US9981925, Compound 47)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(C#N)c(Cl)c3)ncnc12
Show InChI InChI=1/C20H18ClN7O/c21-15-8-12(2-3-13(15)9-22)16(10-28-6-1-7-28)27-20-18-17(25-11-26-20)14(19(23)29)4-5-24-18/h2-5,8,11,16H,1,6-7,10H2,(H2,23,29)(H,25,26,27)/t16-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369757
PNG
(US10233160, Compound 48 | US9981925, Compound 48)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(F)c(c3)C(F)F)ncnc12
Show InChI InChI=1/C20H19F3N6O/c21-14-3-2-11(8-13(14)18(22)23)15(9-29-6-1-7-29)28-20-17-16(26-10-27-20)12(19(24)30)4-5-25-17/h2-5,8,10,15,18H,1,6-7,9H2,(H2,24,30)(H,26,27,28)/t15-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369765
PNG
(US10233160, Compound 56 | US9981925, Compound 56)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1/C19H18F4N6O/c1-2-25-8-14(10-3-4-13(20)12(7-10)19(21,22)23)29-18-16-15(27-9-28-18)11(17(24)30)5-6-26-16/h3-7,9,14,25H,2,8H2,1H3,(H2,24,30)(H,27,28,29)/t14-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369771
PNG
(US10233160, Compound 62 | US9981925, Compound 62)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(F)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18F4N6O/c21-14-3-2-11(8-13(14)20(22,23)24)15(9-30-6-1-7-30)29-19-17-16(27-10-28-19)12(18(25)31)4-5-26-17/h2-5,8,10,15H,1,6-7,9H2,(H2,25,31)(H,27,28,29)/t15-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369777
PNG
(US10233160, Compound 68 | US9981925, Compound 68)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3cccc(F)c3)ncnc12
Show InChI InChI=1/C19H19FN6O/c20-13-4-1-3-12(9-13)15(10-26-7-2-8-26)25-19-17-16(23-11-24-19)14(18(21)27)5-6-22-17/h1,3-6,9,11,15H,2,7-8,10H2,(H2,21,27)(H,23,24,25)/t15-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369723
PNG
(US10233160, Compound 13 | US9981925, Compound 13)
Show SMILES CN(C)C[C@@H](Nc1nnnc2c(cccc12)C(N)=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1/C19H18ClF3N6O/c1-29(2)9-15(10-6-7-14(20)13(8-10)19(21,22)23)25-18-12-5-3-4-11(17(24)30)16(12)26-28-27-18/h3-8,15H,9H2,1-2H3,(H2,24,30)(H,25,26,27)/t15-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369724
PNG
(US10233160, Compound 14 | US9981925, Compound 14)
Show SMILES NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(c3)C(F)(F)F)nnnc12
Show InChI InChI=1/C20H18ClF3N6O/c21-15-6-5-11(9-14(15)20(22,23)24)16(10-30-7-2-8-30)26-19-13-4-1-3-12(18(25)31)17(13)27-29-28-19/h1,3-6,9,16H,2,7-8,10H2,(H2,25,31)(H,26,27,28)/t16-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369728
PNG
(US10233160, Compound 18 | US9981925, Compound 18)
Show SMILES NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(c3)C#N)nnnc12
Show InChI InChI=1/C20H18ClN7O/c21-16-6-5-12(9-13(16)10-22)17(11-28-7-2-8-28)24-20-15-4-1-3-14(19(23)29)18(15)25-27-26-20/h1,3-6,9,17H,2,7-8,11H2,(H2,23,29)(H,24,25,26)/t17-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369731
PNG
(US10233160, Compound 21 | US9981925, Compound 21)
Show SMILES NC(=O)c1cccc2c(NC3CNCCC3c3cccc(c3)C(F)(F)F)nnnc12
Show InChI InChI=1/C20H19F3N6O/c21-20(22,23)12-4-1-3-11(9-12)13-7-8-25-10-16(13)26-19-15-6-2-5-14(18(24)30)17(15)27-29-28-19/h1-6,9,13,16,25H,7-8,10H2,(H2,24,30)(H,26,27,28)
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369735
PNG
(US10233160, Compound 26 | US9981925, Compound 26)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1/C18H16F4N6O/c1-24-7-13(9-2-3-11(12(19)6-9)18(20,21)22)28-17-15-14(26-8-27-17)10(16(23)29)4-5-25-15/h2-6,8,13,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t13-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369738
PNG
(US10233160, Compound 29 | US9981925, Compound 29)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1/C19H18F4N6O/c1-2-25-8-14(10-3-4-12(13(20)7-10)19(21,22)23)29-18-16-15(27-9-28-18)11(17(24)30)5-6-26-16/h3-7,9,14,25H,2,8H2,1H3,(H2,24,30)(H,27,28,29)/t14-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM396709
PNG
(US9981925, Compound 43)
Show SMILES CNC[C@@H](Nc1ncnc2c(nccc12)C(N)=O)c1ccc(c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1S/C19H16F6N6O/c1-27-7-13(9-2-3-11(18(20,21)22)12(6-9)19(23,24)25)31-17-10-4-5-28-15(16(26)32)14(10)29-8-30-17/h2-6,8,13,27H,7H2,1H3,(H2,26,32)(H,29,30,31)/t13-/m1/s1
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369754
PNG
(US10233160, Compound 45 | US9981925, Compound 45)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1/C17H17ClN6O/c1-20-8-13(10-2-4-11(18)5-3-10)24-17-15-14(22-9-23-17)12(16(19)25)6-7-21-15/h2-7,9,13,20H,8H2,1H3,(H2,19,25)(H,22,23,24)/t13-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369761
PNG
(US10233160, Compound 52 | US9981925, Compound 52)
Show SMILES CC(C)NC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1/C20H20F4N6O/c1-10(2)27-8-15(11-3-4-14(21)13(7-11)20(22,23)24)30-19-17-16(28-9-29-19)12(18(25)31)5-6-26-17/h3-7,9-10,15,27H,8H2,1-2H3,(H2,25,31)(H,28,29,30)/t15-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369776
PNG
(US10233160, Compound 67 | US9981925, Compound 67)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(C)c1
Show InChI InChI=1/C18H19FN6O/c1-10-7-11(3-4-13(10)19)14(8-21-2)25-18-16-15(23-9-24-18)12(17(20)26)5-6-22-16/h3-7,9,14,21H,8H2,1-2H3,(H2,20,26)(H,23,24,25)/t14-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369712
PNG
(US10233160, Compound 2 | US9981925, Compound 2)
Show SMILES NC(=O)c1cccc2c(NCc3ccc(Cl)c(Cl)c3)nnnc12
Show InChI InChI=1S/C15H11Cl2N5O/c16-11-5-4-8(6-12(11)17)7-19-15-10-3-1-2-9(14(18)23)13(10)20-22-21-15/h1-6H,7H2,(H2,18,23)(H,19,20,21)
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369722
PNG
(US10233160, Compound 12 | US9981925, Compound 12)
Show SMILES NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(F)c(c3)C(F)(F)F)nnnc12
Show InChI InChI=1/C20H18F4N6O/c21-15-6-5-11(9-14(15)20(22,23)24)16(10-30-7-2-8-30)26-19-13-4-1-3-12(18(25)31)17(13)27-29-28-19/h1,3-6,9,16H,2,7-8,10H2,(H2,25,31)(H,26,27,28)/t16-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369723
PNG
(US10233160, Compound 13 | US9981925, Compound 13)
Show SMILES CN(C)C[C@@H](Nc1nnnc2c(cccc12)C(N)=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1/C19H18ClF3N6O/c1-29(2)9-15(10-6-7-14(20)13(8-10)19(21,22)23)25-18-12-5-3-4-11(17(24)30)16(12)26-28-27-18/h3-8,15H,9H2,1-2H3,(H2,24,30)(H,25,26,27)/t15-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369734
PNG
(US10233160, Compound 25 | US9981925, Compound 25)
Show SMILES NC(=O)c1ccnc2c(NC3CNCCC3c3ccc(cc3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H19F3N6O/c21-20(22,23)12-3-1-11(2-4-12)13-5-7-25-9-15(13)29-19-17-16(27-10-28-19)14(18(24)30)6-8-26-17/h1-4,6,8,10,13,15,25H,5,7,9H2,(H2,24,30)(H,27,28,29)
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369736
PNG
(US10233160, Compound 27 | US9981925, Compound 27)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(cc3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H19F3N6O/c21-20(22,23)13-4-2-12(3-5-13)15(10-29-8-1-9-29)28-19-17-16(26-11-27-19)14(18(24)30)6-7-25-17/h2-7,11,15H,1,8-10H2,(H2,24,30)(H,26,27,28)/t15-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369750
PNG
(US10233160, Compound 41 | US9981925, Compound 71)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18ClF3N6O/c21-14-3-2-11(8-13(14)20(22,23)24)15(9-30-6-1-7-30)29-19-17-16(27-10-28-19)12(18(25)31)4-5-26-17/h2-5,8,10,15H,1,6-7,9H2,(H2,25,31)(H,27,28,29)/t15-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369754
PNG
(US10233160, Compound 45 | US9981925, Compound 45)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)cc1
Show InChI InChI=1/C17H17ClN6O/c1-20-8-13(10-2-4-11(18)5-3-10)24-17-15-14(22-9-23-17)12(16(19)25)6-7-21-15/h2-7,9,13,20H,8H2,1H3,(H2,19,25)(H,22,23,24)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369771
PNG
(US10233160, Compound 62 | US9981925, Compound 62)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(F)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18F4N6O/c21-14-3-2-11(8-13(14)20(22,23)24)15(9-30-6-1-7-30)29-19-17-16(27-10-28-19)12(18(25)31)4-5-26-17/h2-5,8,10,15H,1,6-7,9H2,(H2,25,31)(H,27,28,29)/t15-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369773
PNG
(US10233160, Compound 64 | US9981925, Compound 64)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cccc(Cl)c1
Show InChI InChI=1/C17H17ClN6O/c1-20-8-13(10-3-2-4-11(18)7-10)24-17-15-14(22-9-23-17)12(16(19)25)5-6-21-15/h2-7,9,13,20H,8H2,1H3,(H2,19,25)(H,22,23,24)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369781
PNG
(US10233160, Compound 72 | US9981925, Compound 72)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1/C18H16ClF3N6O/c1-24-7-13(9-2-3-12(19)11(6-9)18(20,21)22)28-17-15-14(26-8-27-17)10(16(23)29)4-5-25-15/h2-6,8,13,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369784
PNG
(US10233160, Compound 75 | US9981925, Compound 75)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(Cl)c1
Show InChI InChI=1/C17H16Cl2N6O/c1-21-7-13(9-2-3-11(18)12(19)6-9)25-17-15-14(23-8-24-17)10(16(20)26)4-5-22-15/h2-6,8,13,21H,7H2,1H3,(H2,20,26)(H,23,24,25)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369726
PNG
(US10233160, Compound 16 | US9981925, Compound 16)
Show SMILES NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(Cl)c3)nnnc12
Show InChI InChI=1/C19H18Cl2N6O/c20-14-6-5-11(9-15(14)21)16(10-27-7-2-8-27)23-19-13-4-1-3-12(18(22)28)17(13)24-26-25-19/h1,3-6,9,16H,2,7-8,10H2,(H2,22,28)(H,23,24,25)/t16-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369744
PNG
(US10233160, Compound 35 | US9981925, Compound 35)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1/C18H16F4N6O/c1-24-7-13(9-4-10(18(20,21)22)6-11(19)5-9)28-17-15-14(26-8-27-17)12(16(23)29)2-3-25-15/h2-6,8,13,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369746
PNG
(US10233160, Compound 37 | US9981925, Compound 37)
Show SMILES CC(C)c1ccc(cc1)[C@@H](CN1CCC1)Nc1ncnc2c(ccnc12)C(N)=O
Show InChI InChI=1/C22H26N6O/c1-14(2)15-4-6-16(7-5-15)18(12-28-10-3-11-28)27-22-20-19(25-13-26-22)17(21(23)29)8-9-24-20/h4-9,13-14,18H,3,10-12H2,1-2H3,(H2,23,29)(H,25,26,27)/t18-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369747
PNG
(US10233160, Compound 38 | US9981925, Compound 38)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1/C18H17F3N6O/c1-23-8-13(10-2-4-11(5-3-10)18(19,20)21)27-17-15-14(25-9-26-17)12(16(22)28)6-7-24-15/h2-7,9,13,23H,8H2,1H3,(H2,22,28)(H,25,26,27)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369758
PNG
(US10233160, Compound 49 | US9981925, Compound 49)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1/C18H16F4N6O/c1-24-7-13(9-2-3-12(19)11(6-9)18(20,21)22)28-17-15-14(26-8-27-17)10(16(23)29)4-5-25-15/h2-6,8,13,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369759
PNG
(US10233160, Compound 50 | US9981925, Compound 50)
Show SMILES CN(C)C[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1/C19H18F4N6O/c1-29(2)8-14(10-3-4-13(20)12(7-10)19(21,22)23)28-18-16-15(26-9-27-18)11(17(24)30)5-6-25-16/h3-7,9,14H,8H2,1-2H3,(H2,24,30)(H,26,27,28)/t14-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369765
PNG
(US10233160, Compound 56 | US9981925, Compound 56)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1/C19H18F4N6O/c1-2-25-8-14(10-3-4-13(20)12(7-10)19(21,22)23)29-18-16-15(27-9-28-18)11(17(24)30)5-6-26-16/h3-7,9,14,25H,2,8H2,1H3,(H2,24,30)(H,27,28,29)/t14-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369770
PNG
(US10233160, Compound 61 | US9981925, Compound 61)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1/C18H18ClFN6O/c1-2-22-8-14(10-3-4-13(20)12(19)7-10)26-18-16-15(24-9-25-18)11(17(21)27)5-6-23-16/h3-7,9,14,22H,2,8H2,1H3,(H2,21,27)(H,24,25,26)/t14-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369750
PNG
(US10233160, Compound 41 | US9981925, Compound 71)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18ClF3N6O/c21-14-3-2-11(8-13(14)20(22,23)24)15(9-30-6-1-7-30)29-19-17-16(27-10-28-19)12(18(25)31)4-5-26-17/h2-5,8,10,15H,1,6-7,9H2,(H2,25,31)(H,27,28,29)/t15-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369750
PNG
(US10233160, Compound 41 | US9981925, Compound 71)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18ClF3N6O/c21-14-3-2-11(8-13(14)20(22,23)24)15(9-30-6-1-7-30)29-19-17-16(27-10-28-19)12(18(25)31)4-5-26-17/h2-5,8,10,15H,1,6-7,9H2,(H2,25,31)(H,27,28,29)/t15-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369714
PNG
(US10233160, Compound 4 | US9981925, Compound 4)
Show SMILES NC(=O)c1cccc2c(NCc3ccc(Cl)c(c3)C(F)(F)F)nnnc12
Show InChI InChI=1S/C16H11ClF3N5O/c17-12-5-4-8(6-11(12)16(18,19)20)7-22-15-10-3-1-2-9(14(21)26)13(10)23-25-24-15/h1-6H,7H2,(H2,21,26)(H,22,23,24)
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369720
PNG
(US10233160, Compound 10 | US9981925, Compound 10)
Show SMILES COc1cc(ccc1Cl)[C@@H](CN1CCC1)Nc1nnnc2c(cccc12)C(N)=O
Show InChI InChI=1/C20H21ClN6O2/c1-29-17-10-12(6-7-15(17)21)16(11-27-8-3-9-27)23-20-14-5-2-4-13(19(22)28)18(14)24-26-25-20/h2,4-7,10,16H,3,8-9,11H2,1H3,(H2,22,28)(H,23,24,25)/t16-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM396690
PNG
(US9981925, Compound 24)
Show SMILES NC(=O)c1ccnc2c(NC3CNCCC3c3cccc(c3)C(F)(F)F)ncnc12
Show InChI InChI=1S/C20H19F3N6O/c21-20(22,23)12-3-1-2-11(8-12)13-4-6-25-9-15(13)29-19-17-16(27-10-28-19)14(18(24)30)5-7-26-17/h1-3,5,7-8,10,13,15,25H,4,6,9H2,(H2,24,30)(H,27,28,29)
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369741
PNG
(US10233160, Compound 32 | US9981925, Compound 32)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)c(OC)cc1F
Show InChI InChI=1/C18H18F2N6O2/c1-22-7-13(10-5-12(20)14(28-2)6-11(10)19)26-18-16-15(24-8-25-18)9(17(21)27)3-4-23-16/h3-6,8,13,22H,7H2,1-2H3,(H2,21,27)(H,24,25,26)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369757
PNG
(US10233160, Compound 48 | US9981925, Compound 48)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(F)c(c3)C(F)F)ncnc12
Show InChI InChI=1/C20H19F3N6O/c21-14-3-2-11(8-13(14)18(22)23)15(9-29-6-1-7-29)28-20-17-16(26-10-27-20)12(19(24)30)4-5-25-17/h2-5,8,10,15,18H,1,6-7,9H2,(H2,24,30)(H,26,27,28)/t15-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369759
PNG
(US10233160, Compound 50 | US9981925, Compound 50)
Show SMILES CN(C)C[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1/C19H18F4N6O/c1-29(2)8-14(10-3-4-13(20)12(7-10)19(21,22)23)28-18-16-15(26-9-27-18)11(17(24)30)5-6-25-16/h3-7,9,14H,8H2,1-2H3,(H2,24,30)(H,26,27,28)/t14-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369764
PNG
(US10233160, Compound 55 | US9981925, Compound 55)
Show SMILES CC(C)NC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1/C20H20ClF3N6O/c1-10(2)27-8-15(11-3-4-14(21)13(7-11)20(22,23)24)30-19-17-16(28-9-29-19)12(18(25)31)5-6-26-17/h3-7,9-10,15,27H,8H2,1-2H3,(H2,25,31)(H,28,29,30)/t15-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369718
PNG
(US10233160, Compound 8 | US9981925, Compound 8)
Show SMILES NC(=O)c1cccc2c(NCc3ccc(cc3)C(F)(F)F)nnnc12
Show InChI InChI=1S/C16H12F3N5O/c17-16(18,19)10-6-4-9(5-7-10)8-21-15-12-3-1-2-11(14(20)25)13(12)22-24-23-15/h1-7H,8H2,(H2,20,25)(H,21,22,23)
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369748
PNG
(US10233160, Compound 39 | US9981925, Compound 39)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(cc1)C(C)C
Show InChI InChI=1/C20H24N6O/c1-12(2)13-4-6-14(7-5-13)16(10-22-3)26-20-18-17(24-11-25-20)15(19(21)27)8-9-23-18/h4-9,11-12,16,22H,10H2,1-3H3,(H2,21,27)(H,24,25,26)/t16-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369758
PNG
(US10233160, Compound 49 | US9981925, Compound 49)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1/C18H16F4N6O/c1-24-7-13(9-2-3-12(19)11(6-9)18(20,21)22)28-17-15-14(26-8-27-17)10(16(23)29)4-5-25-15/h2-6,8,13,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369766
PNG
(US10233160, Compound 57 | US9981925, Compound 57)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1/C17H16ClFN6O/c1-21-7-13(9-2-3-12(19)11(18)6-9)25-17-15-14(23-8-24-17)10(16(20)26)4-5-22-15/h2-6,8,13,21H,7H2,1H3,(H2,20,26)(H,23,24,25)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369741
PNG
(US10233160, Compound 32 | US9981925, Compound 32)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)c(OC)cc1F
Show InChI InChI=1/C18H18F2N6O2/c1-22-7-13(10-5-12(20)14(28-2)6-11(10)19)26-18-16-15(24-8-25-18)9(17(21)27)3-4-23-16/h3-6,8,13,22H,7H2,1-2H3,(H2,21,27)(H,24,25,26)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369761
PNG
(US10233160, Compound 52 | US9981925, Compound 52)
Show SMILES CC(C)NC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(c1)C(F)(F)F
Show InChI InChI=1/C20H20F4N6O/c1-10(2)27-8-15(11-3-4-14(21)13(7-11)20(22,23)24)30-19-17-16(28-9-29-19)12(18(25)31)5-6-26-17/h3-7,9-10,15,27H,8H2,1-2H3,(H2,25,31)(H,28,29,30)/t15-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369776
PNG
(US10233160, Compound 67 | US9981925, Compound 67)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(C)c1
Show InChI InChI=1/C18H19FN6O/c1-10-7-11(3-4-13(10)19)14(8-21-2)25-18-16-15(23-9-24-18)12(17(20)26)5-6-22-16/h3-7,9,14,21H,8H2,1-2H3,(H2,20,26)(H,23,24,25)/t14-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369781
PNG
(US10233160, Compound 72 | US9981925, Compound 72)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1/C18H16ClF3N6O/c1-24-7-13(9-2-3-12(19)11(6-9)18(20,21)22)28-17-15-14(26-8-27-17)10(16(23)29)4-5-25-15/h2-6,8,13,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM396739
PNG
(US9981925, Compound 73)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(OC(F)(F)F)c1
Show InChI InChI=1S/C18H16ClF3N6O2/c1-24-7-12(9-2-3-11(19)13(6-9)30-18(20,21)22)28-17-15-14(26-8-27-17)10(16(23)29)4-5-25-15/h2-6,8,12,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t12-/m1/s1
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369721
PNG
(US10233160, Compound 11 | US9981925, Compound 11)
Show SMILES COc1cc(ccc1Cl)[C@@H](CN(C)C)Nc1nnnc2c(cccc12)C(N)=O
Show InChI InChI=1/C19H21ClN6O2/c1-26(2)10-15(11-7-8-14(20)16(9-11)28-3)22-19-13-6-4-5-12(18(21)27)17(13)23-25-24-19/h4-9,15H,10H2,1-3H3,(H2,21,27)(H,22,23,24)/t15-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369738
PNG
(US10233160, Compound 29 | US9981925, Compound 29)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1/C19H18F4N6O/c1-2-25-8-14(10-3-4-12(13(20)7-10)19(21,22)23)29-18-16-15(27-9-28-18)11(17(24)30)5-6-26-16/h3-7,9,14,25H,2,8H2,1H3,(H2,24,30)(H,27,28,29)/t14-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369777
PNG
(US10233160, Compound 68 | US9981925, Compound 68)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3cccc(F)c3)ncnc12
Show InChI InChI=1/C19H19FN6O/c20-13-4-1-3-12(9-13)15(10-26-7-2-8-26)25-19-17-16(23-11-24-19)14(18(21)27)5-6-22-17/h1,3-6,9,11,15H,2,7-8,10H2,(H2,21,27)(H,23,24,25)/t15-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369727
PNG
(US10233160, Compound 17 | US9981925, Compound 17)
Show SMILES CN(C)C[C@@H](Nc1nnnc2c(cccc12)C(N)=O)c1ccc(Cl)c(c1)C#N
Show InChI InChI=1/C19H18ClN7O/c1-27(2)10-16(11-6-7-15(20)12(8-11)9-21)23-19-14-5-3-4-13(18(22)28)17(14)24-26-25-19/h3-8,16H,10H2,1-2H3,(H2,22,28)(H,23,24,25)/t16-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369739
PNG
(US10233160, Compound 30 | US9981925, Compound 30)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(Br)c1
Show InChI InChI=1/C18H18BrFN6O/c1-2-22-8-14(10-3-4-13(20)12(19)7-10)26-18-16-15(24-9-25-18)11(17(21)27)5-6-23-16/h3-7,9,14,22H,2,8H2,1H3,(H2,21,27)(H,24,25,26)/t14-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369742
PNG
(US10233160, Compound 33 | US9981925, Compound 33)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1/C19H18ClF3N6O/c1-2-25-8-14(10-3-4-13(20)12(7-10)19(21,22)23)29-18-16-15(27-9-28-18)11(17(24)30)5-6-26-16/h3-7,9,14,25H,2,8H2,1H3,(H2,24,30)(H,27,28,29)/t14-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369760
PNG
(US10233160, Compound 51 | US9981925, Compound 51)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(c1)C(F)F
Show InChI InChI=1/C18H17F3N6O/c1-23-7-13(9-2-3-12(19)11(6-9)16(20)21)27-18-15-14(25-8-26-18)10(17(22)28)4-5-24-15/h2-6,8,13,16,23H,7H2,1H3,(H2,22,28)(H,25,26,27)/t13-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369768
PNG
(US10233160, Compound 59 | US9981925, Compound 59)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1/C20H18F6N6O/c1-2-28-8-14(10-3-4-12(19(21,22)23)13(7-10)20(24,25)26)32-18-16-15(30-9-31-18)11(17(27)33)5-6-29-16/h3-7,9,14,28H,2,8H2,1H3,(H2,27,33)(H,30,31,32)/t14-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369769
PNG
(US10233160, Compound 60 | US9981925, Compound 60)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)c(F)cc1F
Show InChI InChI=1/C17H15F3N6O/c1-22-6-13(9-4-11(19)12(20)5-10(9)18)26-17-15-14(24-7-25-17)8(16(21)27)2-3-23-15/h2-5,7,13,22H,6H2,1H3,(H2,21,27)(H,24,25,26)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369733
PNG
(US10233160, Compound 23 | US9981925, Compound 23)
Show SMILES NC(=O)c1ccnc2c(NC3CNCCC3c3ccc(F)c(Cl)c3)ncnc12
Show InChI InChI=1/C19H18ClFN6O/c20-13-7-10(1-2-14(13)21)11-3-5-23-8-15(11)27-19-17-16(25-9-26-19)12(18(22)28)4-6-24-17/h1-2,4,6-7,9,11,15,23H,3,5,8H2,(H2,22,28)(H,25,26,27)
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369737
PNG
(US10233160, Compound 28 | US9981925, Compound 28)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(Br)c1
Show InChI InChI=1/C17H16BrFN6O/c1-21-7-13(9-2-3-12(19)11(18)6-9)25-17-15-14(23-8-24-17)10(16(20)26)4-5-22-15/h2-6,8,13,21H,7H2,1H3,(H2,20,26)(H,23,24,25)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369743
PNG
(US10233160, Compound 34 | US9981925, Compound 34)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1/C19H18F4N6O/c1-2-25-8-14(10-5-11(19(21,22)23)7-12(20)6-10)29-18-16-15(27-9-28-18)13(17(24)30)3-4-26-16/h3-7,9,14,25H,2,8H2,1H3,(H2,24,30)(H,27,28,29)/t14-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369746
PNG
(US10233160, Compound 37 | US9981925, Compound 37)
Show SMILES CC(C)c1ccc(cc1)[C@@H](CN1CCC1)Nc1ncnc2c(ccnc12)C(N)=O
Show InChI InChI=1/C22H26N6O/c1-14(2)15-4-6-16(7-5-15)18(12-28-10-3-11-28)27-22-20-19(25-13-26-22)17(21(23)29)8-9-24-20/h4-9,13-14,18H,3,10-12H2,1-2H3,(H2,23,29)(H,25,26,27)/t18-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369753
PNG
(US10233160, Compound 44 | US9981925, Compound 44)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(C)c1
Show InChI InChI=1/C18H19ClN6O/c1-10-7-11(3-4-13(10)19)14(8-21-2)25-18-16-15(23-9-24-18)12(17(20)26)5-6-22-16/h3-7,9,14,21H,8H2,1-2H3,(H2,20,26)(H,23,24,25)/t14-/s2
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n/an/a 62.5n/an/an/an/an/an/a



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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369762
PNG
(US10233160, Compound 53 | US9981925, Compound 53)
Show SMILES CN(C)C[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(F)c1
Show InChI InChI=1/C18H18ClFN6O/c1-26(2)8-14(10-3-4-12(19)13(20)7-10)25-18-16-15(23-9-24-18)11(17(21)27)5-6-22-16/h3-7,9,14H,8H2,1-2H3,(H2,21,27)(H,23,24,25)/t14-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369764
PNG
(US10233160, Compound 55 | US9981925, Compound 55)
Show SMILES CC(C)NC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1/C20H20ClF3N6O/c1-10(2)27-8-15(11-3-4-14(21)13(7-11)20(22,23)24)30-19-17-16(28-9-29-19)12(18(25)31)5-6-26-17/h3-7,9-10,15,27H,8H2,1-2H3,(H2,25,31)(H,28,29,30)/t15-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369768
PNG
(US10233160, Compound 59 | US9981925, Compound 59)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(c(c1)C(F)(F)F)C(F)(F)F
Show InChI InChI=1/C20H18F6N6O/c1-2-28-8-14(10-3-4-12(19(21,22)23)13(7-10)20(24,25)26)32-18-16-15(30-9-31-18)11(17(27)33)5-6-29-16/h3-7,9,14,28H,2,8H2,1H3,(H2,27,33)(H,30,31,32)/t14-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369778
PNG
(US10233160, Compound 69 | US9981925, Compound 69)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CC(F)C3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H17ClF4N6O/c21-14-2-1-10(5-13(14)20(23,24)25)15(8-31-6-11(22)7-31)30-19-17-16(28-9-29-19)12(18(26)32)3-4-27-17/h1-5,9,11,15H,6-8H2,(H2,26,32)(H,28,29,30)/t15-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369730
PNG
(US10233160, Compound 20 | US9981925, Compound 20)
Show SMILES NC(=O)c1cncc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18ClF3N6O/c21-15-3-2-11(6-14(15)20(22,23)24)16(9-30-4-1-5-30)29-19-13-8-26-7-12(18(25)31)17(13)27-10-28-19/h2-3,6-8,10,16H,1,4-5,9H2,(H2,25,31)(H,27,28,29)/t16-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369744
PNG
(US10233160, Compound 35 | US9981925, Compound 35)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)cc(c1)C(F)(F)F
Show InChI InChI=1/C18H16F4N6O/c1-24-7-13(9-4-10(18(20,21)22)6-11(19)5-9)28-17-15-14(26-8-27-17)12(16(23)29)2-3-25-15/h2-6,8,13,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369762
PNG
(US10233160, Compound 53 | US9981925, Compound 53)
Show SMILES CN(C)C[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(F)c1
Show InChI InChI=1/C18H18ClFN6O/c1-26(2)8-14(10-3-4-12(19)13(20)7-10)25-18-16-15(23-9-24-18)11(17(21)27)5-6-22-16/h3-7,9,14H,8H2,1-2H3,(H2,21,27)(H,23,24,25)/t14-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369668
PNG
(US10233160, Compound 1 | US9981925, Compound 1)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(c3)C(F)(F)F)nnnc12
Show InChI InChI=1S/C16H12F3N5O/c17-16(18,19)10-4-1-3-9(7-10)8-21-15-12-6-2-5-11(14(20)25)13(12)22-24-23-15/h1-7H,8H2,(H2,20,25)(H,21,22,23)
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369728
PNG
(US10233160, Compound 18 | US9981925, Compound 18)
Show SMILES NC(=O)c1cccc2c(N[C@H](CN3CCC3)c3ccc(Cl)c(c3)C#N)nnnc12
Show InChI InChI=1/C20H18ClN7O/c21-16-6-5-12(9-13(16)10-22)17(11-28-7-2-8-28)24-20-15-4-1-3-14(19(23)29)18(15)25-27-26-20/h1,3-6,9,17H,2,7-8,11H2,(H2,23,29)(H,24,25,26)/t17-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369763
PNG
(US10233160, Compound 54 | US9981925, Compound 54)
Show SMILES CC(C)NC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(F)c1
Show InChI InChI=1/C19H20ClFN6O/c1-10(2)24-8-15(11-3-4-13(20)14(21)7-11)27-19-17-16(25-9-26-19)12(18(22)28)5-6-23-17/h3-7,9-10,15,24H,8H2,1-2H3,(H2,22,28)(H,25,26,27)/t15-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369747
PNG
(US10233160, Compound 38 | US9981925, Compound 38)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1/C18H17F3N6O/c1-23-8-13(10-2-4-11(5-3-10)18(19,20)21)27-17-15-14(25-9-26-17)12(16(22)28)6-7-24-15/h2-7,9,13,23H,8H2,1H3,(H2,22,28)(H,25,26,27)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369763
PNG
(US10233160, Compound 54 | US9981925, Compound 54)
Show SMILES CC(C)NC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(F)c1
Show InChI InChI=1/C19H20ClFN6O/c1-10(2)24-8-15(11-3-4-13(20)14(21)7-11)27-19-17-16(25-9-26-19)12(18(22)28)5-6-23-17/h3-7,9-10,15,24H,8H2,1-2H3,(H2,22,28)(H,25,26,27)/t15-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369721
PNG
(US10233160, Compound 11 | US9981925, Compound 11)
Show SMILES COc1cc(ccc1Cl)[C@@H](CN(C)C)Nc1nnnc2c(cccc12)C(N)=O
Show InChI InChI=1/C19H21ClN6O2/c1-26(2)10-15(11-7-8-14(20)16(9-11)28-3)22-19-13-6-4-5-12(18(21)27)17(13)23-25-24-19/h4-9,15H,10H2,1-3H3,(H2,21,27)(H,22,23,24)/t15-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369727
PNG
(US10233160, Compound 17 | US9981925, Compound 17)
Show SMILES CN(C)C[C@@H](Nc1nnnc2c(cccc12)C(N)=O)c1ccc(Cl)c(c1)C#N
Show InChI InChI=1/C19H18ClN7O/c1-27(2)10-16(11-6-7-15(20)12(8-11)9-21)23-19-14-5-3-4-13(18(22)28)17(14)24-26-25-19/h3-8,16H,10H2,1-2H3,(H2,22,28)(H,23,24,25)/t16-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369732
PNG
(US10233160, Compound 22 | US9981925, Compound 22)
Show SMILES NC(=O)c1cccc2c(NC3CNCCC3c3ccc(cc3)C(F)(F)F)nnnc12
Show InChI InChI=1/C20H19F3N6O/c21-20(22,23)12-6-4-11(5-7-12)13-8-9-25-10-16(13)26-19-15-3-1-2-14(18(24)30)17(15)27-29-28-19/h1-7,13,16,25H,8-10H2,(H2,24,30)(H,26,27,28)
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369760
PNG
(US10233160, Compound 51 | US9981925, Compound 51)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(c1)C(F)F
Show InChI InChI=1/C18H17F3N6O/c1-23-7-13(9-2-3-12(19)11(6-9)16(20)21)27-18-15-14(25-8-26-18)10(17(22)28)4-5-24-15/h2-6,8,13,16,23H,7H2,1H3,(H2,22,28)(H,25,26,27)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369766
PNG
(US10233160, Compound 57 | US9981925, Compound 57)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(Cl)c1
Show InChI InChI=1/C17H16ClFN6O/c1-21-7-13(9-2-3-12(19)11(18)6-9)25-17-15-14(23-8-24-17)10(16(20)26)4-5-22-15/h2-6,8,13,21H,7H2,1H3,(H2,20,26)(H,23,24,25)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369720
PNG
(US10233160, Compound 10 | US9981925, Compound 10)
Show SMILES COc1cc(ccc1Cl)[C@@H](CN1CCC1)Nc1nnnc2c(cccc12)C(N)=O
Show InChI InChI=1/C20H21ClN6O2/c1-29-17-10-12(6-7-15(17)21)16(11-27-8-3-9-27)23-20-14-5-2-4-13(19(22)28)18(14)24-26-25-20/h2,4-7,10,16H,3,8-9,11H2,1H3,(H2,22,28)(H,23,24,25)/t16-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369735
PNG
(US10233160, Compound 26 | US9981925, Compound 26)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(c(F)c1)C(F)(F)F
Show InChI InChI=1/C18H16F4N6O/c1-24-7-13(9-2-3-11(12(19)6-9)18(20,21)22)28-17-15-14(26-8-27-17)10(16(23)29)4-5-25-15/h2-6,8,13,24H,7H2,1H3,(H2,23,29)(H,26,27,28)/t13-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369740
PNG
(US10233160, Compound 31 | US9981925, Compound 31)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1cc(F)c(OC)cc1F
Show InChI InChI=1/C19H20F2N6O2/c1-3-23-8-14(11-6-13(21)15(29-2)7-12(11)20)27-19-17-16(25-9-26-19)10(18(22)28)4-5-24-17/h4-7,9,14,23H,3,8H2,1-2H3,(H2,22,28)(H,25,26,27)/t14-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369742
PNG
(US10233160, Compound 33 | US9981925, Compound 33)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1/C19H18ClF3N6O/c1-2-25-8-14(10-3-4-13(20)12(7-10)19(21,22)23)29-18-16-15(27-9-28-18)11(17(24)30)5-6-26-16/h3-7,9,14,25H,2,8H2,1H3,(H2,24,30)(H,27,28,29)/t14-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369733
PNG
(US10233160, Compound 23 | US9981925, Compound 23)
Show SMILES NC(=O)c1ccnc2c(NC3CNCCC3c3ccc(F)c(Cl)c3)ncnc12
Show InChI InChI=1/C19H18ClFN6O/c20-13-7-10(1-2-14(13)21)11-3-5-23-8-15(11)27-19-17-16(25-9-26-19)12(18(22)28)4-6-24-17/h1-2,4,6-7,9,11,15,23H,3,5,8H2,(H2,22,28)(H,25,26,27)
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM396690
PNG
(US9981925, Compound 24)
Show SMILES NC(=O)c1ccnc2c(NC3CNCCC3c3cccc(c3)C(F)(F)F)ncnc12
Show InChI InChI=1S/C20H19F3N6O/c21-20(22,23)12-3-1-2-11(8-12)13-4-6-25-9-15(13)29-19-17-16(27-10-28-19)14(18(24)30)5-7-26-17/h1-3,5,7-8,10,13,15,25H,4,6,9H2,(H2,24,30)(H,27,28,29)
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Merck Patent GmbH

US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369719
PNG
(US10233160, Compound 9 | US9981925, Compound 9)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(F)c3)nnnc12
Show InChI InChI=1S/C15H12FN5O/c16-10-4-1-3-9(7-10)8-18-15-12-6-2-5-11(14(17)22)13(12)19-21-20-15/h1-7H,8H2,(H2,17,22)(H,18,19,20)
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369745
PNG
(US10233160, Compound 36 | US9981925, Compound 36)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CCC3)c3ccc(Cl)cc3)ncnc12
Show InChI InChI=1/C19H19ClN6O/c20-13-4-2-12(3-5-13)15(10-26-8-1-9-26)25-19-17-16(23-11-24-19)14(18(21)27)6-7-22-17/h2-7,11,15H,1,8-10H2,(H2,21,27)(H,23,24,25)/t15-/s2
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Merck Patent GmbH

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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369779
PNG
(US10233160, Compound 70 | US9981925, Compound 70)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CC(O)C3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18ClF3N6O2/c21-14-2-1-10(5-13(14)20(22,23)24)15(8-30-6-11(31)7-30)29-19-17-16(27-9-28-19)12(18(25)32)3-4-26-17/h1-5,9,11,15,31H,6-8H2,(H2,25,32)(H,27,28,29)/t15-/s2
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369716
PNG
(US10233160, Compound 6 | US9981925, Compound 6)
Show SMILES NC(=O)c1cccc2c(NCc3ccccc3)nnnc12
Show InChI InChI=1S/C15H13N5O/c16-14(21)11-7-4-8-12-13(11)18-20-19-15(12)17-9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,16,21)(H,17,18,19)
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Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369729
PNG
(US10233160, Compound 19 | US9981925, Compound 19)
Show SMILES NC(=O)c1cncc2c(N[C@@H](CN3CCC3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18ClF3N6O/c21-15-3-2-11(6-14(15)20(22,23)24)16(9-30-4-1-5-30)29-19-13-8-26-7-12(18(25)31)17(13)27-10-28-19/h2-3,6-8,10,16H,1,4-5,9H2,(H2,25,31)(H,27,28,29)/t16-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369713
PNG
(US10233160, Compound 3 | US9981925, Compound 3)
Show SMILES NC(=O)c1cccc2c(NCc3cccnc3)nnnc12
Show InChI InChI=1S/C14H12N6O/c15-13(21)10-4-1-5-11-12(10)18-20-19-14(11)17-8-9-3-2-6-16-7-9/h1-7H,8H2,(H2,15,21)(H,17,18,19)
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369713
PNG
(US10233160, Compound 3 | US9981925, Compound 3)
Show SMILES NC(=O)c1cccc2c(NCc3cccnc3)nnnc12
Show InChI InChI=1S/C14H12N6O/c15-13(21)10-4-1-5-11-12(10)18-20-19-14(11)17-8-9-3-2-6-16-7-9/h1-7H,8H2,(H2,15,21)(H,17,18,19)
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Merck Patent GmbH

US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369729
PNG
(US10233160, Compound 19 | US9981925, Compound 19)
Show SMILES NC(=O)c1cncc2c(N[C@@H](CN3CCC3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18ClF3N6O/c21-15-3-2-11(6-14(15)20(22,23)24)16(9-30-4-1-5-30)29-19-13-8-26-7-12(18(25)31)17(13)27-10-28-19/h2-3,6-8,10,16H,1,4-5,9H2,(H2,25,31)(H,27,28,29)/t16-/s2
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369716
PNG
(US10233160, Compound 6 | US9981925, Compound 6)
Show SMILES NC(=O)c1cccc2c(NCc3ccccc3)nnnc12
Show InChI InChI=1S/C15H13N5O/c16-14(21)11-7-4-8-12-13(11)18-20-19-15(12)17-9-10-5-2-1-3-6-10/h1-8H,9H2,(H2,16,21)(H,17,18,19)
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369717
PNG
(US10233160, Compound 7 | US9981925, Compound 7)
Show SMILES NC(=O)c1cccc2c(NCc3ccc(cn3)C(F)(F)F)nnnc12
Show InChI InChI=1S/C15H11F3N6O/c16-15(17,18)8-4-5-9(20-6-8)7-21-14-11-3-1-2-10(13(19)25)12(11)22-24-23-14/h1-6H,7H2,(H2,19,25)(H,21,22,23)
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369719
PNG
(US10233160, Compound 9 | US9981925, Compound 9)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(F)c3)nnnc12
Show InChI InChI=1S/C15H12FN5O/c16-10-4-1-3-9(7-10)8-18-15-12-6-2-5-11(14(17)22)13(12)19-21-20-15/h1-7H,8H2,(H2,17,22)(H,18,19,20)
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369739
PNG
(US10233160, Compound 30 | US9981925, Compound 30)
Show SMILES CCNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(F)c(Br)c1
Show InChI InChI=1/C18H18BrFN6O/c1-2-22-8-14(10-3-4-13(20)12(19)7-10)26-18-16-15(24-9-25-18)11(17(21)27)5-6-23-16/h3-7,9,14,22H,2,8H2,1H3,(H2,21,27)(H,24,25,26)/t14-/s2
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
Ribosomal protein S6 kinase (P70S6K)


(Homo sapiens (Human))
BDBM369715
PNG
(US10233160, Compound 5 | US9981925, Compound 5)
Show SMILES NC(=O)c1cccc2c(NCc3ccccn3)nnnc12
Show InChI InChI=1S/C14H12N6O/c15-13(21)10-5-3-6-11-12(10)18-20-19-14(11)17-8-9-4-1-2-7-16-9/h1-7H,8H2,(H2,15,21)(H,17,18,19)
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US Patent


Assay Description
p70S6K inhibitor compounds were diluted and plated in 96 well plates. A reaction mixture including the following components were then added to the co...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369715
PNG
(US10233160, Compound 5 | US9981925, Compound 5)
Show SMILES NC(=O)c1cccc2c(NCc3ccccn3)nnnc12
Show InChI InChI=1S/C14H12N6O/c15-13(21)10-5-3-6-11-12(10)18-20-19-14(11)17-8-9-4-1-2-7-16-9/h1-7H,8H2,(H2,15,21)(H,17,18,19)
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369717
PNG
(US10233160, Compound 7 | US9981925, Compound 7)
Show SMILES NC(=O)c1cccc2c(NCc3ccc(cn3)C(F)(F)F)nnnc12
Show InChI InChI=1S/C15H11F3N6O/c16-15(17,18)8-4-5-9(20-6-8)7-21-14-11-3-1-2-10(13(19)25)12(11)22-24-23-14/h1-6H,7H2,(H2,19,25)(H,21,22,23)
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369712
PNG
(US10233160, Compound 2 | US9981925, Compound 2)
Show SMILES NC(=O)c1cccc2c(NCc3ccc(Cl)c(Cl)c3)nnnc12
Show InChI InChI=1S/C15H11Cl2N5O/c16-11-5-4-8(6-12(11)17)7-19-15-10-3-1-2-9(14(18)23)13(10)20-22-21-15/h1-6H,7H2,(H2,18,23)(H,19,20,21)
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369668
PNG
(US10233160, Compound 1 | US9981925, Compound 1)
Show SMILES NC(=O)c1cccc2c(NCc3cccc(c3)C(F)(F)F)nnnc12
Show InChI InChI=1S/C16H12F3N5O/c17-16(18,19)10-4-1-3-9(7-10)8-21-15-12-6-2-5-11(14(20)25)13(12)22-24-23-15/h1-7H,8H2,(H2,20,25)(H,21,22,23)
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US Patent


Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369779
PNG
(US10233160, Compound 70 | US9981925, Compound 70)
Show SMILES NC(=O)c1ccnc2c(N[C@H](CN3CC(O)C3)c3ccc(Cl)c(c3)C(F)(F)F)ncnc12
Show InChI InChI=1/C20H18ClF3N6O2/c21-14-2-1-10(5-13(14)20(22,23)24)15(8-30-6-11(31)7-30)29-19-17-16(27-9-28-19)12(18(25)32)3-4-26-17/h1-5,9,11,15,31H,6-8H2,(H2,25,32)(H,27,28,29)/t15-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369748
PNG
(US10233160, Compound 39 | US9981925, Compound 39)
Show SMILES CNC[C@@H](Nc1ncnc2c(ccnc12)C(N)=O)c1ccc(cc1)C(C)C
Show InChI InChI=1/C20H24N6O/c1-12(2)13-4-6-14(7-5-13)16(10-22-3)26-20-18-17(24-11-25-20)15(19(21)27)8-9-23-18/h4-9,11-12,16,22H,10H2,1-3H3,(H2,21,27)(H,24,25,26)/t16-/s2
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369714
PNG
(US10233160, Compound 4 | US9981925, Compound 4)
Show SMILES NC(=O)c1cccc2c(NCc3ccc(Cl)c(c3)C(F)(F)F)nnnc12
Show InChI InChI=1S/C16H11ClF3N5O/c17-12-5-4-8(6-11(12)16(18,19)20)7-22-15-10-3-1-2-9(14(21)26)13(10)23-25-24-15/h1-6H,7H2,(H2,21,26)(H,22,23,24)
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
RAC-alpha serine/threonine-protein kinase AKT1


(Homo sapiens (Human))
BDBM369718
PNG
(US10233160, Compound 8 | US9981925, Compound 8)
Show SMILES NC(=O)c1cccc2c(NCc3ccc(cc3)C(F)(F)F)nnnc12
Show InChI InChI=1S/C16H12F3N5O/c17-16(18,19)10-6-4-9(5-7-10)8-21-15-12-3-1-2-11(14(20)25)13(12)22-24-23-15/h1-7H,8H2,(H2,20,25)(H,21,22,23)
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Assay Description
In order to measure AKT inhibition in the Caliper Life Sciences LC3000, a TTP Mosquito liquid handling instrument was used to place 125 nl of the app...


US Patent US9981925 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%