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Patent code US9981950

Compile Data Set for Download or QSAR
Found 116 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396904
PNG
(US9981950, Example 113B)
Show SMILES Nc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C13H11F3N6/c14-11-2-1-9(5-10(11)12(15)16)22-7-8(19-20-22)6-21-4-3-18-13(21)17/h1-5,7,12H,6H2,(H2,17,18)
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n/an/a 0.480n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396905
PNG
(US9981950, Example 114)
Show SMILES CC(F)(F)c1cc(ccc1F)-n1cc(Cn2ccnc2N)nn1
Show InChI InChI=1S/C14H13F3N6/c1-14(16,17)11-6-10(2-3-12(11)15)23-8-9(20-21-23)7-22-5-4-19-13(22)18/h2-6,8H,7H2,1H3,(H2,18,19)
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n/an/a 0.510n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396901
PNG
(US9981950, Example 110)
Show SMILES Nc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1
Show InChI InChI=1S/C13H11ClF2N6O/c14-10-2-1-9(5-11(10)23-12(15)16)22-7-8(19-20-22)6-21-4-3-18-13(21)17/h1-5,7,12H,6H2,(H2,17,18)
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n/an/a 0.520n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396903
PNG
(US9981950, Example 113A)
Show SMILES Nc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(c1)C(F)F
Show InChI InChI=1S/C13H11ClF2N6/c14-11-2-1-9(5-10(11)12(15)16)22-7-8(19-20-22)6-21-4-3-18-13(21)17/h1-5,7,12H,6H2,(H2,17,18)
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n/an/a 0.650n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396886
PNG
(US9981950, Example 93)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1
Show InChI InChI=1S/C14H12ClF2N5O/c1-9-18-4-5-21(9)7-10-8-22(20-19-10)11-2-3-12(15)13(6-11)23-14(16)17/h2-6,8,14H,7H2,1H3
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n/an/a 1.20n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396889
PNG
(US9981950, Example 96)
Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1
Show InChI InChI=1S/C15H14ClF2N5O/c1-2-14-19-5-6-22(14)8-10-9-23(21-20-10)11-3-4-12(16)13(7-11)24-15(17)18/h3-7,9,15H,2,8H2,1H3
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n/an/a 1.60n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396848
PNG
(US9981950, Example 55)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C14H14ClN5/c1-10-7-13(3-4-14(10)15)20-9-12(17-18-20)8-19-6-5-16-11(19)2/h3-7,9H,8H2,1-2H3
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n/an/a 1.64n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396863
PNG
(US9981950, Example 70)
Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C15H16ClN5/c1-3-15-17-6-7-20(15)9-12-10-21(19-18-12)13-4-5-14(16)11(2)8-13/h4-8,10H,3,9H2,1-2H3
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n/an/a 1.84n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396893
PNG
(US9981950, Example 100)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(F)c(OC(F)F)c1
Show InChI InChI=1S/C14H12F3N5O/c1-9-18-4-5-21(9)7-10-8-22(20-19-10)11-2-3-12(15)13(6-11)23-14(16)17/h2-6,8,14H,7H2,1H3
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n/an/a 1.90n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396902
PNG
(US9981950, Example 111)
Show SMILES Nc1nccn1Cc1cn(nn1)-c1cc(F)cc(c1)C(F)F
Show InChI InChI=1S/C13H11F3N6/c14-9-3-8(12(15)16)4-11(5-9)22-7-10(19-20-22)6-21-2-1-18-13(21)17/h1-5,7,12H,6H2,(H2,17,18)
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n/an/a 2.13n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396891
PNG
(US9981950, Example 98)
Show SMILES OCCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1
Show InChI InChI=1S/C15H14ClF2N5O2/c16-12-2-1-11(7-13(12)25-15(17)18)23-9-10(20-21-23)8-22-5-4-19-14(22)3-6-24/h1-2,4-5,7,9,15,24H,3,6,8H2
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n/an/a 2.26n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396884
PNG
(US9981950, Example 91)
Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(c1)C(F)F
Show InChI InChI=1S/C15H14ClF2N5/c1-2-14-19-5-6-22(14)8-10-9-23(21-20-10)11-3-4-13(16)12(7-11)15(17)18/h3-7,9,15H,2,8H2,1H3
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n/an/a 2.43n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396890
PNG
(US9981950, Example 97)
Show SMILES CC(C)c1nccn1Cc1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1
Show InChI InChI=1S/C16H16ClF2N5O/c1-10(2)15-20-5-6-23(15)8-11-9-24(22-21-11)12-3-4-13(17)14(7-12)25-16(18)19/h3-7,9-10,16H,8H2,1-2H3
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n/an/a 3.12n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396882
PNG
(US9981950, Example 89)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(c1)C(F)F
Show InChI InChI=1S/C14H12ClF2N5/c1-9-18-4-5-21(9)7-10-8-22(20-19-10)11-2-3-13(15)12(6-11)14(16)17/h2-6,8,14H,7H2,1H3
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n/an/a 3.37n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396878
PNG
(US9981950, Example 85)
Show SMILES CCCc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C16H16F3N5/c1-2-3-15-20-6-7-23(15)9-11-10-24(22-21-11)12-4-5-14(17)13(8-12)16(18)19/h4-8,10,16H,2-3,9H2,1H3
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n/an/a 3.40n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396874
PNG
(US9981950, Example 81)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C14H12F3N5/c1-9-18-4-5-21(9)7-10-8-22(20-19-10)11-2-3-13(15)12(6-11)14(16)17/h2-6,8,14H,7H2,1H3
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n/an/a 3.83n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396887
PNG
(US9981950, Example 94)
Show SMILES FC(F)Oc1cc(ccc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C16H14ClF2N5O/c17-13-4-3-12(7-14(13)25-16(18)19)24-9-11(21-22-24)8-23-6-5-20-15(23)10-1-2-10/h3-7,9-10,16H,1-2,8H2
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n/an/a 3.91n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396898
PNG
(US9981950, Example 105)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(C)(F)F
Show InChI InChI=1S/C15H14F3N5/c1-10-19-5-6-22(10)8-11-9-23(21-20-11)12-3-4-14(16)13(7-12)15(2,17)18/h3-7,9H,8H2,1-2H3
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n/an/a 4.05n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396876
PNG
(US9981950, Example 83)
Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C15H14F3N5/c1-2-14-19-5-6-22(14)8-10-9-23(21-20-10)11-3-4-13(16)12(7-11)15(17)18/h3-7,9,15H,2,8H2,1H3
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n/an/a 4.11n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396894
PNG
(US9981950, Example 101)
Show SMILES OCCc1nccn1Cc1cn(nn1)-c1ccc(F)c(OC(F)F)c1
Show InChI InChI=1S/C15H14F3N5O2/c16-12-2-1-11(7-13(12)25-15(17)18)23-9-10(20-21-23)8-22-5-4-19-14(22)3-6-24/h1-2,4-5,7,9,15,24H,3,6,8H2
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n/an/a 4.26n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396879
PNG
(US9981950, Example 86)
Show SMILES CCCCc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C17H18F3N5/c1-2-3-4-16-21-7-8-24(16)10-12-11-25(23-22-12)13-5-6-15(18)14(9-13)17(19)20/h5-9,11,17H,2-4,10H2,1H3
PDB
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n/an/a 4.29n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396864
PNG
(US9981950, Example 71)
Show SMILES CC(C)c1nccn1Cc1cn(nn1)-c1ccc(Cl)c(C)c1
Show InChI InChI=1S/C16H18ClN5/c1-11(2)16-18-6-7-21(16)9-13-10-22(20-19-13)14-4-5-15(17)12(3)8-14/h4-8,10-11H,9H2,1-3H3
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n/an/a 4.47n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396826
PNG
(US9981950, Example 33)
Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H13Cl2N5/c1-2-14-17-5-6-20(14)8-10-9-21(19-18-10)11-3-4-12(15)13(16)7-11/h3-7,9H,2,8H2,1H3
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n/an/a 4.65n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396825
PNG
(US9981950, Example 32)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C13H11Cl2N5/c1-9-16-4-5-19(9)7-10-8-20(18-17-10)11-2-3-12(14)13(15)6-11/h2-6,8H,7H2,1H3
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n/an/a 4.92n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396835
PNG
(US9981950, Example 42)
Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C14H13ClFN5/c1-2-14-17-5-6-20(14)8-10-9-21(19-18-10)11-3-4-13(16)12(15)7-11/h3-7,9H,2,8H2,1H3
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n/an/a 5.02n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396885
PNG
(US9981950, Example 92)
Show SMILES CC(C)c1nccn1Cc1cn(nn1)-c1ccc(Cl)c(c1)C(F)F
Show InChI InChI=1S/C16H16ClF2N5/c1-10(2)16-20-5-6-23(16)8-11-9-24(22-21-11)12-3-4-14(17)13(7-12)15(18)19/h3-7,9-10,15H,8H2,1-2H3
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n/an/a 5.24n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396847
PNG
(US9981950, Example 54)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(F)c(C)c1
Show InChI InChI=1S/C14H14FN5/c1-10-7-13(3-4-14(10)15)20-9-12(17-18-20)8-19-6-5-16-11(19)2/h3-7,9H,8H2,1-2H3
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n/an/a 5.32n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396892
PNG
(US9981950, Example 99)
Show SMILES FCCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1
Show InChI InChI=1S/C15H13ClF3N5O/c16-12-2-1-11(7-13(12)25-15(18)19)24-9-10(21-22-24)8-23-6-5-20-14(23)3-4-17/h1-2,5-7,9,15H,3-4,8H2
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n/an/a 6.02n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396830
PNG
(US9981950, Example 37)
Show SMILES CCCCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H17Cl2N5/c1-2-3-4-16-19-7-8-22(16)10-12-11-23(21-20-12)13-5-6-14(17)15(18)9-13/h5-9,11H,2-4,10H2,1H3
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n/an/a 6.84n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396867
PNG
(US9981950, Example 74)
Show SMILES Cc1cc(ccc1Cl)-n1cc(Cn2ccnc2CCO)nn1
Show InChI InChI=1S/C15H16ClN5O/c1-11-8-13(2-3-14(11)16)21-10-12(18-19-21)9-20-6-5-17-15(20)4-7-22/h2-3,5-6,8,10,22H,4,7,9H2,1H3
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n/an/a 6.90n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396844
PNG
(US9981950, Example 51)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C13H11ClFN5/c1-9-16-4-5-19(9)7-10-8-20(18-17-10)11-2-3-13(15)12(14)6-11/h2-6,8H,7H2,1H3
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n/an/a 7.01n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396850
PNG
(US9981950, Example 57)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C14H12F3N5O/c1-10-18-5-6-21(10)8-11-9-22(20-19-11)12-3-2-4-13(7-12)23-14(15,16)17/h2-7,9H,8H2,1H3
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n/an/a 7.21n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396828
PNG
(US9981950, Example 35)
Show SMILES CC(C)c1nccn1Cc1cn(nn1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H15Cl2N5/c1-10(2)15-18-5-6-21(15)8-11-9-22(20-19-11)12-3-4-13(16)14(17)7-12/h3-7,9-10H,8H2,1-2H3
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n/an/a 7.40n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396832
PNG
(US9981950, Example 39)
Show SMILES Clc1ccc(cc1Cl)-n1cc(Cn2ccnc2C2CCC2)nn1
Show InChI InChI=1S/C16H15Cl2N5/c17-14-5-4-13(8-15(14)18)23-10-12(20-21-23)9-22-7-6-19-16(22)11-2-1-3-11/h4-8,10-11H,1-3,9H2
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n/an/a 7.58n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396827
PNG
(US9981950, Example 34)
Show SMILES CCCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C15H15Cl2N5/c1-2-3-15-18-6-7-21(15)9-11-10-22(20-19-11)12-4-5-13(16)14(17)8-12/h4-8,10H,2-3,9H2,1H3
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n/an/a 7.67n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396838
PNG
(US9981950, Example 45)
Show SMILES CCCCc1nccn1Cc1cn(nn1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C16H17ClFN5/c1-2-3-4-16-19-7-8-22(16)10-12-11-23(21-20-12)13-5-6-15(18)14(17)9-13/h5-9,11H,2-4,10H2,1H3
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n/an/a 7.68n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396899
PNG
(US9981950, Example 106)
Show SMILES CC(F)(F)c1cc(ccc1F)-n1cc(Cn2ccnc2CCO)nn1
Show InChI InChI=1S/C16H16F3N5O/c1-16(18,19)13-8-12(2-3-14(13)17)24-10-11(21-22-24)9-23-6-5-20-15(23)4-7-25/h2-3,5-6,8,10,25H,4,7,9H2,1H3
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n/an/a 8.08n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396836
PNG
(US9981950, Example 43)
Show SMILES CCCc1nccn1Cc1cn(nn1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C15H15ClFN5/c1-2-3-15-18-6-7-21(15)9-11-10-22(20-19-11)12-4-5-14(17)13(16)8-12/h4-8,10H,2-3,9H2,1H3
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n/an/a 9.84n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396877
PNG
(US9981950, Example 84)
Show SMILES CC(C)c1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C16H16F3N5/c1-10(2)16-20-5-6-23(16)8-11-9-24(22-21-11)12-3-4-14(17)13(7-12)15(18)19/h3-7,9-10,15H,8H2,1-2H3
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n/an/a 11n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396865
PNG
(US9981950, Example 72)
Show SMILES CCc1nccn1Cc1cn(nn1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C15H14F3N5O/c1-2-14-19-6-7-22(14)9-11-10-23(21-20-11)12-4-3-5-13(8-12)24-15(16,17)18/h3-8,10H,2,9H2,1H3
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n/an/a 11.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396849
PNG
(US9981950, Example 56)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(c1)C(F)(F)F
Show InChI InChI=1S/C14H11ClF3N5/c1-9-19-4-5-22(9)7-10-8-23(21-20-10)11-2-3-13(15)12(6-11)14(16,17)18/h2-6,8H,7H2,1H3
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n/an/a 11.9n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396858
PNG
(US9981950, Example 65)
Show SMILES Cc1cc(ccc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C16H16ClN5/c1-11-8-14(4-5-15(11)17)22-10-13(19-20-22)9-21-7-6-18-16(21)12-2-3-12/h4-8,10,12H,2-3,9H2,1H3
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n/an/a 12.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396868
PNG
(US9981950, Example 75)
Show SMILES Cc1cc(ccc1Cl)-n1cc(Cn2ccnc2CCF)nn1
Show InChI InChI=1S/C15H15ClFN5/c1-11-8-13(2-3-14(11)16)22-10-12(19-20-22)9-21-7-6-18-15(21)4-5-17/h2-3,6-8,10H,4-5,9H2,1H3
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n/an/a 13.5n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396881
PNG
(US9981950, Example 88)
Show SMILES OCCc1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C15H14F3N5O/c16-13-2-1-11(7-12(13)15(17)18)23-9-10(20-21-23)8-22-5-4-19-14(22)3-6-24/h1-2,4-5,7,9,15,24H,3,6,8H2
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n/an/a 14.5n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396857
PNG
(US9981950, Example 64)
Show SMILES Cc1cc(ccc1F)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C16H16FN5/c1-11-8-14(4-5-15(11)17)22-10-13(19-20-22)9-21-7-6-18-16(21)12-2-3-12/h4-8,10,12H,2-3,9H2,1H3
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n/an/a 15.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396883
PNG
(US9981950, Example 90)
Show SMILES FC(F)c1cc(ccc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C16H14ClF2N5/c17-14-4-3-12(7-13(14)15(18)19)24-9-11(21-22-24)8-23-6-5-20-16(23)10-1-2-10/h3-7,9-10,15H,1-2,8H2
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n/an/a 15.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396869
PNG
(US9981950, Example 76)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C16H17N5/c1-12-17-7-8-20(12)10-15-11-21(19-18-15)16-4-2-3-14(9-16)13-5-6-13/h2-4,7-9,11,13H,5-6,10H2,1H3
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n/an/a 15.9n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396875
PNG
(US9981950, Example 82)
Show SMILES FC(F)c1cc(ccc1F)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C16H14F3N5/c17-14-4-3-12(7-13(14)15(18)19)24-9-11(21-22-24)8-23-6-5-20-16(23)10-1-2-10/h3-7,9-10,15H,1-2,8H2
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n/an/a 16.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396833
PNG
(US9981950, Example 40)
Show SMILES OCCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H13Cl2N5O/c15-12-2-1-11(7-13(12)16)21-9-10(18-19-21)8-20-5-4-17-14(20)3-6-22/h1-2,4-5,7,9,22H,3,6,8H2
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n/an/a 17.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396851
PNG
(US9981950, Example 58)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C14H12F3N5/c1-10-18-5-6-21(10)8-12-9-22(20-19-12)13-4-2-3-11(7-13)14(15,16)17/h2-7,9H,8H2,1H3
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n/an/a 17.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396829
PNG
(US9981950, Example 36)
Show SMILES Clc1ccc(cc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C15H13Cl2N5/c16-13-4-3-12(7-14(13)17)22-9-11(19-20-22)8-21-6-5-18-15(21)10-1-2-10/h3-7,9-10H,1-2,8H2
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n/an/a 17.9n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396843
PNG
(US9981950, Example 50)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(F)c1
Show InChI InChI=1S/C13H11ClFN5/c1-9-16-4-5-19(9)7-10-8-20(18-17-10)11-2-3-12(14)13(15)6-11/h2-6,8H,7H2,1H3
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n/an/a 21.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396818
PNG
(US9981950, Example 25)
Show SMILES CCc1nccn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H14ClN5/c1-2-14-16-7-8-19(14)9-12-10-20(18-17-12)13-5-3-11(15)4-6-13/h3-8,10H,2,9H2,1H3
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n/an/a 25.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396895
PNG
(US9981950, Example 102)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1cc(F)cc(c1)C(F)F
Show InChI InChI=1S/C14H12F3N5/c1-9-18-2-3-21(9)7-12-8-22(20-19-12)13-5-10(14(16)17)4-11(15)6-13/h2-6,8,14H,7H2,1H3
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n/an/a 25.9n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396834
PNG
(US9981950, Example 41)
Show SMILES FCCc1nccn1Cc1cn(nn1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C14H12Cl2FN5/c15-12-2-1-11(7-13(12)16)22-9-10(19-20-22)8-21-6-5-18-14(21)3-4-17/h1-2,5-7,9H,3-4,8H2
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n/an/a 26.2n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396846
PNG
(US9981950, Example 53)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(C)c(F)c1
Show InChI InChI=1S/C14H14FN5/c1-10-3-4-13(7-14(10)15)20-9-12(17-18-20)8-19-6-5-16-11(19)2/h3-7,9H,8H2,1-2H3
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n/an/a 26.5n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396837
PNG
(US9981950, Example 44)
Show SMILES Fc1ccc(cc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C15H13ClFN5/c16-13-7-12(3-4-14(13)17)22-9-11(19-20-22)8-21-6-5-18-15(21)10-1-2-10/h3-7,9-10H,1-2,8H2
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n/an/a 28.3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396854
PNG
(US9981950, Example 61)
Show SMILES Fc1cc(ccc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C15H13ClFN5/c16-13-4-3-12(7-14(13)17)22-9-11(19-20-22)8-21-6-5-18-15(21)10-1-2-10/h3-7,9-10H,1-2,8H2
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n/an/a 31.7n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396866
PNG
(US9981950, Example 73)
Show SMILES CC(C)c1nccn1Cc1cn(nn1)-c1cccc(OC(F)(F)F)c1
Show InChI InChI=1S/C16H16F3N5O/c1-11(2)15-20-6-7-23(15)9-12-10-24(22-21-12)13-4-3-5-14(8-13)25-16(17,18)19/h3-8,10-11H,9H2,1-2H3
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n/an/a 32.7n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396860
PNG
(US9981950, Example 67)
Show SMILES FC(F)(F)Oc1cccc(c1)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C16H14F3N5O/c17-16(18,19)25-14-3-1-2-13(8-14)24-10-12(21-22-24)9-23-7-6-20-15(23)11-4-5-11/h1-3,6-8,10-11H,4-5,9H2
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n/an/a 34.5n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396859
PNG
(US9981950, Example 66)
Show SMILES FC(F)(F)c1cc(ccc1Cl)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C16H13ClF3N5/c17-14-4-3-12(7-13(14)16(18,19)20)25-9-11(22-23-25)8-24-6-5-21-15(24)10-1-2-10/h3-7,9-10H,1-2,8H2
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n/an/a 38n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396817
PNG
(US9981950, Example 24)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C13H12ClN5/c1-10-15-6-7-18(10)8-12-9-19(17-16-12)13-4-2-11(14)3-5-13/h2-7,9H,8H2,1H3
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n/an/a 38.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396820
PNG
(US9981950, Example 27)
Show SMILES CCCCc1nccn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H18ClN5/c1-2-3-4-16-18-9-10-21(16)11-14-12-22(20-19-14)15-7-5-13(17)6-8-15/h5-10,12H,2-4,11H2,1H3
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n/an/a 38.9n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396871
PNG
(US9981950, Example 78)
Show SMILES OCCc1nccn1Cc1cn(nn1)-c1cccc(c1)C1CC1
Show InChI InChI=1S/C17H19N5O/c23-9-6-17-18-7-8-21(17)11-15-12-22(20-19-15)16-3-1-2-14(10-16)13-4-5-13/h1-3,7-8,10,12-13,23H,4-6,9,11H2
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n/an/a 41.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396852
PNG
(US9981950, Example 59)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C14H12F3N5/c1-10-18-6-7-21(10)8-12-9-22(20-19-12)13-4-2-11(3-5-13)14(15,16)17/h2-7,9H,8H2,1H3
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n/an/a 46n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396811
PNG
(US9981950, Example 18)
Show SMILES CCCc1nccn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H16ClN5/c1-2-3-15-17-8-9-20(15)10-13-11-21(19-18-13)14-6-4-12(16)5-7-14/h4-9,11H,2-3,10H2,1H3
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n/an/a 46.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396888
PNG
(US9981950, Example 95)
Show SMILES CC(C)(C)c1nccn1Cc1cn(nn1)-c1ccc(Cl)c(OC(F)F)c1
Show InChI InChI=1S/C17H18ClF2N5O/c1-17(2,3)15-21-6-7-24(15)9-11-10-25(23-22-11)12-4-5-13(18)14(8-12)26-16(19)20/h4-8,10,16H,9H2,1-3H3
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n/an/a 72.9n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396816
PNG
(US9981950, Example 23)
Show SMILES CC(C)c1nccn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H16ClN5/c1-11(2)15-17-7-8-20(15)9-13-10-21(19-18-13)14-5-3-12(16)4-6-14/h3-8,10-11H,9H2,1-2H3
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n/an/a 77.4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396856
PNG
(US9981950, Example 63)
Show SMILES Cc1ccc(cc1F)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C16H16FN5/c1-11-2-5-14(8-15(11)17)22-10-13(19-20-22)9-21-7-6-18-16(21)12-3-4-12/h2,5-8,10,12H,3-4,9H2,1H3
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n/an/a 87.1n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396861
PNG
(US9981950, Example 68)
Show SMILES FC(F)(F)c1cccc(c1)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C16H14F3N5/c17-16(18,19)12-2-1-3-14(8-12)24-10-13(21-22-24)9-23-7-6-20-15(23)11-4-5-11/h1-3,6-8,10-11H,4-5,9H2
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n/an/a 91.6n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396822
PNG
(US9981950, Example 29)
Show SMILES Clc1ccc(cc1)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C15H14ClN5/c16-12-3-5-14(6-4-12)21-10-13(18-19-21)9-20-8-7-17-15(20)11-1-2-11/h3-8,10-11H,1-2,9H2
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n/an/a 95.8n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396880
PNG
(US9981950, Example 87)
Show SMILES CC(C)(C)c1nccn1Cc1cn(nn1)-c1ccc(F)c(c1)C(F)F
Show InChI InChI=1S/C17H18F3N5/c1-17(2,3)16-21-6-7-24(16)9-11-10-25(23-22-11)12-4-5-14(18)13(8-12)15(19)20/h4-8,10,15H,9H2,1-3H3
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n/an/a 131n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396896
PNG
(US9981950, Example 103)
Show SMILES OCCc1nccn1Cc1cn(nn1)-c1cc(F)cc(c1)C(F)F
Show InChI InChI=1S/C15H14F3N5O/c16-11-5-10(15(17)18)6-13(7-11)23-9-12(20-21-23)8-22-3-2-19-14(22)1-4-24/h2-3,5-7,9,15,24H,1,4,8H2
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n/an/a 136n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396908
PNG
(US9981950, Example 117)
Show SMILES Cc1nc2ccccc2n1Cc1cn(nn1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C17H13Cl2N5/c1-11-20-16-4-2-3-5-17(16)23(11)9-12-10-24(22-21-12)13-6-7-14(18)15(19)8-13/h2-8,10H,9H2,1H3
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n/an/a 141n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396862
PNG
(US9981950, Example 69)
Show SMILES FC(F)(F)c1ccc(cc1)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C16H14F3N5/c17-16(18,19)12-3-5-14(6-4-12)24-10-13(21-22-24)9-23-8-7-20-15(23)11-1-2-11/h3-8,10-11H,1-2,9H2
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n/an/a 173n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396897
PNG
(US9981950, Example 104)
Show SMILES FCCc1nccn1Cc1cn(cn1)-c1cc(F)cc(c1)C(F)F
Show InChI InChI=1S/C16H14F4N4/c17-2-1-15-21-3-4-23(15)8-13-9-24(10-22-13)14-6-11(16(19)20)5-12(18)7-14/h3-7,9-10,16H,1-2,8H2
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n/an/a 186n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396906
PNG
(US9981950, Example 115)
Show SMILES FC(F)c1cc(ccc1F)-n1cc(Cc2cc[nH]n2)nn1
Show InChI InChI=1S/C13H10F3N5/c14-12-2-1-10(6-11(12)13(15)16)21-7-9(19-20-21)5-8-3-4-17-18-8/h1-4,6-7,13H,5H2,(H,17,18)
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n/an/a 236n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396909
PNG
(US9981950, Example 118)
Show SMILES OCCc1nccn1Cn1cc(nn1)-c1ccc(cc1)S(F)(F)(F)(F)F
Show InChI InChI=1S/C14H14F5N5OS/c15-26(16,17,18,19)12-3-1-11(2-4-12)13-9-24(22-21-13)10-23-7-6-20-14(23)5-8-25/h1-4,6-7,9,25H,5,8,10H2
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n/an/a 263n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396831
PNG
(US9981950, Example 38)
Show SMILES CC(C)(C)c1nccn1Cc1cn(nn1)-c1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H17Cl2N5/c1-16(2,3)15-19-6-7-22(15)9-11-10-23(21-20-11)12-4-5-13(17)14(18)8-12/h4-8,10H,9H2,1-3H3
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n/an/a 526n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396821
PNG
(US9981950, Example 28)
Show SMILES OCc1nccn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C13H12ClN5O/c14-10-1-3-12(4-2-10)19-8-11(16-17-19)7-18-6-5-15-13(18)9-20/h1-6,8,20H,7,9H2
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n/an/a 573n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396870
PNG
(US9981950, Example 77)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C14H15N5O2S/c1-11-15-6-7-18(11)9-12-10-19(17-16-12)13-4-3-5-14(8-13)22(2,20)21/h3-8,10H,9H2,1-2H3
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n/an/a 615n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396842
PNG
(US9981950, Example 49)
Show SMILES Cc1nccn1Cc1cn(nn1)-c1ccc(Cl)cc1Cl
Show InChI InChI=1S/C13H11Cl2N5/c1-9-16-4-5-19(9)7-11-8-20(18-17-11)13-3-2-10(14)6-12(13)15/h2-6,8H,7H2,1H3
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n/an/a 778n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396804
PNG
(US9981950, Example 11)
Show SMILES Clc1ccc(cc1)-n1cc(Cn2ncnc2C2CCC2)nn1
Show InChI InChI=1S/C15H15ClN6/c16-12-4-6-14(7-5-12)21-8-13(19-20-21)9-22-15(17-10-18-22)11-2-1-3-11/h4-8,10-11H,1-3,9H2
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n/an/a>1.00E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396795
PNG
(US9981950, Example 2)
Show SMILES CCCc1ncnn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H15ClN6/c1-2-3-14-16-10-17-21(14)9-12-8-20(19-18-12)13-6-4-11(15)5-7-13/h4-8,10H,2-3,9H2,1H3
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n/an/a>1.00E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396845
PNG
(US9981950, Example 52)
Show SMILES COc1cc(F)ccc1-n1cc(Cn2ccnc2C)nn1
Show InChI InChI=1S/C14H14FN5O/c1-10-16-5-6-19(10)8-12-9-20(18-17-12)13-4-3-11(15)7-14(13)21-2/h3-7,9H,8H2,1-2H3
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n/an/a 1.18E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396872
PNG
(US9981950, Example 79)
Show SMILES CS(=O)(=O)c1cccc(c1)-n1cc(Cn2ccnc2CCO)nn1
Show InChI InChI=1S/C15H17N5O3S/c1-24(22,23)14-4-2-3-13(9-14)20-11-12(17-18-20)10-19-7-6-16-15(19)5-8-21/h2-4,6-7,9,11,21H,5,8,10H2,1H3
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n/an/a 1.40E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396853
PNG
(US9981950, Example 60)
Show SMILES Clc1ccc(c(Cl)c1)-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C15H13Cl2N5/c16-11-3-4-14(13(17)7-11)22-9-12(19-20-22)8-21-6-5-18-15(21)10-1-2-10/h3-7,9-10H,1-2,8H2
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n/an/a 1.62E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396873
PNG
(US9981950, Example 80)
Show SMILES CS(=O)(=O)c1cccc(c1)-n1cc(Cn2ccnc2CCF)nn1
Show InChI InChI=1S/C15H16FN5O2S/c1-24(22,23)14-4-2-3-13(9-14)21-11-12(18-19-21)10-20-8-7-17-15(20)5-6-16/h2-4,7-9,11H,5-6,10H2,1H3
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n/an/a 2.68E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396855
PNG
(US9981950, Example 62)
Show SMILES COc1cc(F)ccc1-n1cc(Cn2ccnc2C2CC2)nn1
Show InChI InChI=1S/C16H16FN5O/c1-23-15-8-12(17)4-5-14(15)22-10-13(19-20-22)9-21-7-6-18-16(21)11-2-3-11/h4-8,10-11H,2-3,9H2,1H3
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n/an/a 3.32E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396900
PNG
(US9981950, Example 109)
Show SMILES Cn1nccc1Cc1cn(nn1)-c1ccc(F)c(Cl)c1
Show InChI InChI=1S/C13H11ClFN5/c1-19-10(4-5-16-19)6-9-8-20(18-17-9)11-2-3-13(15)12(14)7-11/h2-5,7-8H,6H2,1H3
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n/an/a 4.32E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396907
PNG
(US9981950, Example 116)
Show SMILES Cc1ccc(cc1)C(=O)c1nccn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C20H16ClN5O/c1-14-2-4-15(5-3-14)19(27)20-22-10-11-25(20)12-17-13-26(24-23-17)18-8-6-16(21)7-9-18/h2-11,13H,12H2,1H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396823
PNG
(2-tert-butyl-1H- imidazole 4-(2-tert-Butyl-imidazo...)
Show SMILES CC(C)(C)c1nccn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H18ClN5/c1-16(2,3)15-18-8-9-21(15)10-13-11-22(20-19-13)14-6-4-12(17)5-7-14/h4-9,11H,10H2,1-3H3
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n/an/a 7.20E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396819
PNG
(US9981950, Example 26)
Show SMILES Clc1nccn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H9Cl2N5/c13-9-1-3-11(4-2-9)19-8-10(16-17-19)7-18-6-5-15-12(18)14/h1-6,8H,7H2
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n/an/a 9.93E+3n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396805
PNG
(US9981950, Example 12)
Show SMILES Clc1ccc(cc1)-n1cc(Cn2cnc(n2)C2CCC2)nn1
Show InChI InChI=1S/C15H15ClN6/c16-12-4-6-14(7-5-12)22-9-13(18-20-22)8-21-10-17-15(19-21)11-2-1-3-11/h4-7,9-11H,1-3,8H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396839
PNG
(US9981950, Example 46)
Show SMILES Cc1nc(C)n(Cc2cn(nn2)-c2ccccc2)n1
Show InChI InChI=1S/C13H14N6/c1-10-14-11(2)18(16-10)8-12-9-19(17-15-12)13-6-4-3-5-7-13/h3-7,9H,8H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396798
PNG
(US9981950, Example 5)
Show SMILES CCc1ncnn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C13H13ClN6/c1-2-13-15-9-16-20(13)8-11-7-19(18-17-11)12-5-3-10(14)4-6-12/h3-7,9H,2,8H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396808
PNG
(US9981950, Example 15)
Show SMILES Clc1ccc(cc1)-n1cc(Cn2cnc(n2)C2CCCC2)nn1
Show InChI InChI=1S/C16H17ClN6/c17-13-5-7-15(8-6-13)23-10-14(19-21-23)9-22-11-18-16(20-22)12-3-1-2-4-12/h5-8,10-12H,1-4,9H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396812
PNG
(US9981950, Example 19)
Show SMILES CC(C)(C)c1ncnn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C15H17ClN6/c1-15(2,3)14-17-10-18-22(14)9-12-8-21(20-19-12)13-6-4-11(16)5-7-13/h4-8,10H,9H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396815
PNG
(US9981950, Example 22)
Show SMILES Cc1nc(nn1Cc1cn(nn1)-c1ccc(Cl)cc1)C1CCC1
Show InChI InChI=1S/C16H17ClN6/c1-11-18-16(12-3-2-4-12)20-22(11)9-14-10-23(21-19-14)15-7-5-13(17)6-8-15/h5-8,10,12H,2-4,9H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396840
PNG
(US9981950, Example 47)
Show SMILES Cc1nc(CO)n(Cc2cn(nn2)-c2ccccc2)n1
Show InChI InChI=1S/C13H14N6O/c1-10-14-13(9-20)19(16-10)8-11-7-18(17-15-11)12-5-3-2-4-6-12/h2-7,20H,8-9H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396799
PNG
(US9981950, Example 6)
Show SMILES CCc1ncn(Cc2cn(nn2)-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C13H13ClN6/c1-2-13-15-9-19(17-13)7-11-8-20(18-16-11)12-5-3-10(14)4-6-12/h3-6,8-9H,2,7H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396814
PNG
(US9981950, Example 21)
Show SMILES Cc1nc(C2CCC2)n(Cc2cn(nn2)-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C16H17ClN6/c1-11-18-16(12-3-2-4-12)23(20-11)10-14-9-22(21-19-14)15-7-5-13(17)6-8-15/h5-9,12H,2-4,10H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396806
PNG
(US9981950, Example 13)
Show SMILES Clc1ccc(cc1)-n1cc(Cn2cnc(n2)C2CC2)nn1
Show InChI InChI=1S/C14H13ClN6/c15-11-3-5-13(6-4-11)21-8-12(17-19-21)7-20-9-16-14(18-20)10-1-2-10/h3-6,8-10H,1-2,7H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396803
PNG
(US9981950, Example 10)
Show SMILES Clc1ccc(cc1)-n1cc(Cn2nc(nc2C2CC2)C2CC2)nn1
Show InChI InChI=1S/C17H17ClN6/c18-13-5-7-15(8-6-13)23-9-14(20-22-23)10-24-17(12-3-4-12)19-16(21-24)11-1-2-11/h5-9,11-12H,1-4,10H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396809
PNG
(US9981950, Example 16)
Show SMILES Clc1ccc(cc1)-n1cc(Cn2ncnc2C2CC2)nn1
Show InChI InChI=1S/C14H13ClN6/c15-11-3-5-13(6-4-11)20-7-12(18-19-20)8-21-14(10-1-2-10)16-9-17-21/h3-7,9-10H,1-2,8H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396810
PNG
(US9981950, Example 17)
Show SMILES FC(F)(F)c1ncn(Cc2cn(nn2)-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C12H8ClF3N6/c13-8-1-3-10(4-2-8)22-6-9(18-20-22)5-21-7-17-11(19-21)12(14,15)16/h1-4,6-7H,5H2
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396813
PNG
(US9981950, Example 20)
Show SMILES CC(C)(C)c1ncn(Cc2cn(nn2)-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C15H17ClN6/c1-15(2,3)14-17-10-21(19-14)8-12-9-22(20-18-12)13-6-4-11(16)5-7-13/h4-7,9-10H,8H2,1-3H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396824
PNG
(2-methyl-1H- imidazole 1-(4-Chloro-phenyl)-4-(3-me...)
Show SMILES Cc1nncn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H11ClN6/c1-9-15-14-8-18(9)6-11-7-19(17-16-11)12-4-2-10(13)3-5-12/h2-5,7-8H,6H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396796
PNG
(US9981950, Example 3)
Show SMILES CCCc1ncn(Cc2cn(nn2)-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C14H15ClN6/c1-2-3-14-16-10-20(18-14)8-12-9-21(19-17-12)13-6-4-11(15)5-7-13/h4-7,9-10H,2-3,8H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396800
PNG
(US9981950, Example 7)
Show SMILES CC(C)c1ncnn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C14H15ClN6/c1-10(2)14-16-9-17-21(14)8-12-7-20(19-18-12)13-5-3-11(15)4-6-13/h3-7,9-10H,8H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396841
PNG
(US9981950, Example 48)
Show SMILES Cc1nc(CO)nn1Cc1cn(nn1)-c1ccccc1
Show InChI InChI=1S/C13H14N6O/c1-10-14-13(9-20)16-18(10)7-11-8-19(17-15-11)12-5-3-2-4-6-12/h2-6,8,20H,7,9H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396794
PNG
(US9981950, Example 1)
Show SMILES Cc1nc(C)n(Cc2cn(nn2)-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C13H13ClN6/c1-9-15-10(2)19(17-9)7-12-8-20(18-16-12)13-5-3-11(14)4-6-13/h3-6,8H,7H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396797
PNG
(US9981950, Example 4)
Show SMILES CC(C)c1ncn(Cc2cn(nn2)-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C14H15ClN6/c1-10(2)14-16-9-20(18-14)7-12-8-21(19-17-12)13-5-3-11(15)4-6-13/h3-6,8-10H,7H2,1-2H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396802
PNG
(US9981950, Example 9)
Show SMILES Cc1ncn(Cc2cn(nn2)-c2ccc(Cl)cc2)n1
Show InChI InChI=1S/C12H11ClN6/c1-9-14-8-18(16-9)6-11-7-19(17-15-11)12-4-2-10(13)3-5-12/h2-5,7-8H,6H2,1H3
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n/an/a>1.00E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396807
PNG
(US9981950, Example 14)
Show SMILES Clc1ccc(cc1)-n1cc(Cn2ncnc2C2CCCC2)nn1
Show InChI InChI=1S/C16H17ClN6/c17-13-5-7-15(8-6-13)22-9-14(20-21-22)10-23-16(18-11-19-23)12-3-1-2-4-12/h5-9,11-12H,1-4,10H2
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n/an/a 1.25E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2


(Homo sapiens (Human))
BDBM396801
PNG
(US9981950, Example 8)
Show SMILES Cc1ncnn1Cc1cn(nn1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C12H11ClN6/c1-9-14-8-15-18(9)6-11-7-19(17-16-11)12-4-2-10(13)3-5-12/h2-5,7-8H,6H2,1H3
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n/an/a 1.43E+4n/an/an/an/an/an/a



JANSSEN PHARMACEUTICALS, INC.

US Patent


Assay Description
Cells were split 2-3 times weekly between 1:3 and 1:4. For binding assays and membrane preparations the cell culture medium was removed, cells were w...


US Patent US9981950 (2018)


BindingDB Entry DOI: 10.7270/Q2TH8Q1D
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%