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Patent code US9981975

Compile Data Set for Download or QSAR

Found 438 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397025
PNG
(US9981975, Example 87)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cnn(C)c4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C33H38N10O4/c1-19(2)31(45)40-12-10-22(11-13-40)27-14-25(28-29(34)35-18-37-43(27)28)21-6-8-23(9-7-21)38-30(44)26-17-41(20(3)4)33(47)42(32(26)46)24-15-36-39(5)16-24/h6-9,14-20,22H,10-13H2,1-5H3,(H,38,44)(H2,34,35,37)
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US Patent


Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397035
PNG
(US9981975, Example 99)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(C)c(-c4cncc(c4)C#N)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C37H39N9O3/c1-21(2)37(49)44-12-10-26(11-13-44)31-15-29(33-35(39)41-20-42-46(31)33)25-6-8-28(9-7-25)43-36(48)30-19-45(22(3)4)23(5)32(34(30)47)27-14-24(16-38)17-40-18-27/h6-9,14-15,17-22,26H,10-13H2,1-5H3,(H,43,48)(H2,39,41,42)
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US Patent


Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397041
PNG
(US9981975, Example 105)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3ccc(-c4ccc(C)nc4)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C39H38N8O3/c1-24(2)38(49)45-19-17-27(18-20-45)34-21-32(35-36(40)42-23-43-47(34)35)26-11-13-29(14-12-26)44-37(48)31-15-16-33(28-10-9-25(3)41-22-28)46(39(31)50)30-7-5-4-6-8-30/h4-16,21-24,27H,17-20H2,1-3H3,(H,44,48)(H2,40,42,43)
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US Patent


Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397047
PNG
(US9981975, Example 111)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C#N)c(C)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C35H34N8O3/c1-21(2)34(45)41-15-13-24(14-16-41)30-18-28(31-32(37)38-20-39-43(30)31)23-9-11-26(12-10-23)40-33(44)29-17-25(19-36)22(3)42(35(29)46)27-7-5-4-6-8-27/h4-12,17-18,20-21,24H,13-16H2,1-3H3,(H,40,44)(H2,37,38,39)
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US Patent


Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397051
PNG
(US9981975, Example 114)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)CC(C)(C)Cc4n(-c4cccnc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C38H40N8O4/c1-22(2)36(49)44-14-11-24(12-15-44)30-17-27(33-34(39)41-21-42-46(30)33)23-7-9-25(10-8-23)43-35(48)29-16-28-31(18-38(3,4)19-32(28)47)45(37(29)50)26-6-5-13-40-20-26/h5-10,13,16-17,20-22,24H,11-12,14-15,18-19H2,1-4H3,(H,43,48)(H2,39,41,42)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397052
PNG
(US9981975, Example 115)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)C(C)(C)CCc4n(-c4cncc(F)c4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C38H39FN8O4/c1-21(2)36(50)45-13-10-23(11-14-45)31-17-27(32-34(40)42-20-43-47(31)32)22-5-7-25(8-6-22)44-35(49)29-16-28-30(9-12-38(3,4)33(28)48)46(37(29)51)26-15-24(39)18-41-19-26/h5-8,15-21,23H,9-14H2,1-4H3,(H,44,49)(H2,40,42,43)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397058
PNG
(US9981975, Example 121)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C)c(C)n(-c4cncc(F)c4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H35FN8O3/c1-19(2)33(45)41-11-9-23(10-12-41)29-15-27(30-31(36)38-18-39-43(29)30)22-5-7-25(8-6-22)40-32(44)28-13-20(3)21(4)42(34(28)46)26-14-24(35)16-37-17-26/h5-8,13-19,23H,9-12H2,1-4H3,(H,40,44)(H2,36,38,39)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397060
PNG
(US9981975, Example 123)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(-c4ccnn4C)c(C)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C37H38N10O3/c1-22(2)36(49)45-17-13-25(14-18-45)31-20-28(33-34(38)40-21-42-47(31)33)24-8-10-26(11-9-24)43-35(48)29-19-27(30-12-16-41-44(30)4)23(3)46(37(29)50)32-7-5-6-15-39-32/h5-12,15-16,19-22,25H,13-14,17-18H2,1-4H3,(H,43,48)(H2,38,40,42)
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US Patent


Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397065
PNG
(US9981975, Example 128)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(cc(-c4cccnc4)c3=O)C(C)C)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C35H38N8O3/c1-21(2)35(46)41-14-11-24(12-15-41)30-16-27(31-33(36)38-20-39-43(30)31)23-7-9-26(10-8-23)40-34(45)29-19-42(22(3)4)18-28(32(29)44)25-6-5-13-37-17-25/h5-10,13,16-22,24H,11-12,14-15H2,1-4H3,(H,40,45)(H2,36,38,39)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397066
PNG
(US9981975, Example 129)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(cc(-c4cncc(F)c4)c3=O)C(C)C)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C35H37FN8O3/c1-20(2)35(47)42-11-9-23(10-12-42)30-14-27(31-33(37)39-19-40-44(30)31)22-5-7-26(8-6-22)41-34(46)29-18-43(21(3)4)17-28(32(29)45)24-13-25(36)16-38-15-24/h5-8,13-21,23H,9-12H2,1-4H3,(H,41,46)(H2,37,39,40)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397070
PNG
(US9981975, Example 133)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(-c4cnn(C)c4)c(C)n(-c4cccnc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C37H38N10O3/c1-22(2)36(49)45-14-11-25(12-15-45)32-17-30(33-34(38)40-21-42-47(32)33)24-7-9-27(10-8-24)43-35(48)31-16-29(26-18-41-44(4)20-26)23(3)46(37(31)50)28-6-5-13-39-19-28/h5-10,13,16-22,25H,11-12,14-15H2,1-4H3,(H,43,48)(H2,38,40,42)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397071
PNG
(US9981975, Example 134)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(-c4ccnn4C)c(C)n(-c4cccnc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C37H38N10O3/c1-22(2)36(49)45-16-12-25(13-17-45)32-19-29(33-34(38)40-21-42-47(32)33)24-7-9-26(10-8-24)43-35(48)30-18-28(31-11-15-41-44(31)4)23(3)46(37(30)50)27-6-5-14-39-20-27/h5-11,14-15,18-22,25H,12-13,16-17H2,1-4H3,(H,43,48)(H2,38,40,42)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397082
PNG
(US9981975, Example 147)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4cccnc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C36H38N8O3/c1-21(2)36(47)42-15-12-24(13-16-42)30-17-28(32-34(37)39-20-40-44(30)32)23-6-8-26(9-7-23)41-35(46)29-19-43(27-10-11-27)22(3)31(33(29)45)25-5-4-14-38-18-25/h4-9,14,17-21,24,27H,10-13,15-16H2,1-3H3,(H,41,46)(H2,37,39,40)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396950
PNG
(US9981975, Example 12)
Show SMILES CCc1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C26H21FN6O2/c1-2-17-14-21(23-24(28)29-15-30-33(17)23)19-11-10-16(13-22(19)27)31-25(34)20-9-6-12-32(26(20)35)18-7-4-3-5-8-18/h3-15H,2H2,1H3,(H,31,34)(H2,28,29,30)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396952
PNG
(US9981975, Example 14)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCOCC1
Show InChI InChI=1S/C29H25FN6O3/c30-20-5-9-22(10-6-20)35-13-1-2-23(29(35)38)28(37)34-21-7-3-18(4-8-21)24-16-25(19-11-14-39-15-12-19)36-26(24)27(31)32-17-33-36/h1-10,13,16-17,19H,11-12,14-15H2,(H,34,37)(H2,31,32,33)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396952
PNG
(US9981975, Example 14)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCOCC1
Show InChI InChI=1S/C29H25FN6O3/c30-20-5-9-22(10-6-20)35-13-1-2-23(29(35)38)28(37)34-21-7-3-18(4-8-21)24-16-25(19-11-14-39-15-12-19)36-26(24)27(31)32-17-33-36/h1-10,13,16-17,19H,11-12,14-15H2,(H,34,37)(H2,31,32,33)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396954
PNG
(US9981975, Example 16)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCOCC1
Show InChI InChI=1S/C29H24F2N6O3/c30-18-3-6-20(7-4-18)36-11-1-2-22(29(36)39)28(38)35-19-5-8-21(24(31)14-19)23-15-25(17-9-12-40-13-10-17)37-26(23)27(32)33-16-34-37/h1-8,11,14-17H,9-10,12-13H2,(H,35,38)(H2,32,33,34)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396961
PNG
(US9981975, Example 23)
Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C30H27F2N7O2/c1-37-13-10-18(11-14-37)26-16-24(27-28(33)34-17-35-39(26)27)22-9-6-20(15-25(22)32)36-29(40)23-3-2-12-38(30(23)41)21-7-4-19(31)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,36,40)(H2,33,34,35)
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US Patent


Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396963
PNG
(US9981975, Example 25)
Show SMILES CC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C31H28FN7O3/c1-19(40)37-15-12-21(13-16-37)27-17-26(28-29(33)34-18-35-39(27)28)20-4-8-23(9-5-20)36-30(41)25-3-2-14-38(31(25)42)24-10-6-22(32)7-11-24/h2-11,14,17-18,21H,12-13,15-16H2,1H3,(H,36,41)(H2,33,34,35)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396971
PNG
(US9981975, Example 33)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3)c12)C1CCNCC1
Show InChI InChI=1S/C29H26FN7O2/c30-20-5-9-22(10-6-20)36-15-1-2-23(29(36)39)28(38)35-21-7-3-18(4-8-21)24-16-25(19-11-13-32-14-12-19)37-26(24)27(31)33-17-34-37/h1-10,15-17,19,32H,11-14H2,(H,35,38)(H2,31,33,34)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396977
PNG
(US9981975, Example 39)
Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C31H27F2N7O4/c1-44-31(43)38-13-10-18(11-14-38)26-16-24(27-28(34)35-17-36-40(26)27)22-9-6-20(15-25(22)33)37-29(41)23-3-2-12-39(30(23)42)21-7-4-19(32)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,37,41)(H2,34,35,36)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396981
PNG
(US9981975, Example 43)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C30H27F2N7O4S/c1-44(42,43)37-13-10-18(11-14-37)26-16-24(27-28(33)34-17-35-39(26)27)22-9-6-20(15-25(22)32)36-29(40)23-3-2-12-38(30(23)41)21-7-4-19(31)5-8-21/h2-9,12,15-18H,10-11,13-14H2,1H3,(H,36,40)(H2,33,34,35)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396984
PNG
(US9981975, Example 46)
Show SMILES CN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C32H31FN8O3/c1-38(2)32(44)39-15-12-20(13-16-39)27-18-25(28-29(34)35-19-36-41(27)28)23-11-10-21(17-26(23)33)37-30(42)24-9-6-14-40(31(24)43)22-7-4-3-5-8-22/h3-11,14,17-20H,12-13,15-16H2,1-2H3,(H,37,42)(H2,34,35,36)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397008
PNG
(US9981975, Example 70)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(C3CCN(CC3)C(=O)N(C)C)n3ncnc(N)c23)c(=O)n(-c2cccc(F)c2)c1=O
Show InChI InChI=1S/C34H36FN9O4/c1-20(2)42-18-27(32(46)43(34(42)48)25-7-5-6-23(35)16-25)31(45)39-24-10-8-21(9-11-24)26-17-28(44-29(26)30(36)37-19-38-44)22-12-14-41(15-13-22)33(47)40(3)4/h5-11,16-20,22H,12-15H2,1-4H3,(H,39,45)(H2,36,37,38)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397014
PNG
(US9981975, Example 76)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4cc(F)ccc4F)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C35H36F2N8O4/c1-19(2)33(47)42-13-11-22(12-14-42)28-16-25(30-31(38)39-18-40-45(28)30)21-5-8-24(9-6-21)41-32(46)26-17-43(20(3)4)35(49)44(34(26)48)29-15-23(36)7-10-27(29)37/h5-10,15-20,22H,11-14H2,1-4H3,(H,41,46)(H2,38,39,40)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397031
PNG
(US9981975, Example 95)
Show SMILES CC(C)n1cc(C(=O)Nc2ccc(cc2)-c2cc(CN3CCOCC3)n3ncnc(N)c23)c(=O)n(-c2ccccc2)c1=O
Show InChI InChI=1S/C31H32N8O4/c1-20(2)37-18-26(30(41)38(31(37)42)23-6-4-3-5-7-23)29(40)35-22-10-8-21(9-11-22)25-16-24(17-36-12-14-43-15-13-36)39-27(25)28(32)33-19-34-39/h3-11,16,18-20H,12-15,17H2,1-2H3,(H,35,40)(H2,32,33,34)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397034
PNG
(US9981975, Example 98)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(C)c(-c4cncc(F)c4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C36H39FN8O3/c1-20(2)36(48)43-12-10-24(11-13-43)30-15-28(32-34(38)40-19-41-45(30)32)23-6-8-27(9-7-23)42-35(47)29-18-44(21(3)4)22(5)31(33(29)46)25-14-26(37)17-39-16-25/h6-9,14-21,24H,10-13H2,1-5H3,(H,42,47)(H2,38,40,41)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397037
PNG
(US9981975, Example 101)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(Br)c(C)n(-c4cncc(F)c4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C33H32BrFN8O3/c1-18(2)32(45)41-10-8-21(9-11-41)28-14-25(29-30(36)38-17-39-43(28)29)20-4-6-23(7-5-20)40-31(44)26-13-27(34)19(3)42(33(26)46)24-12-22(35)15-37-16-24/h4-7,12-18,21H,8-11H2,1-3H3,(H,40,44)(H2,36,38,39)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397045
PNG
(US9981975, Example 109)
Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(c(C)n(-c4ccccc4)c3=O)-c3ncccn3)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C35H33N9O2/c1-22-27(33-37-15-6-16-38-33)19-29(35(46)43(22)26-7-4-3-5-8-26)34(45)41-25-11-9-23(10-12-25)28-20-30(24-13-17-42(2)18-14-24)44-31(28)32(36)39-21-40-44/h3-12,15-16,19-21,24H,13-14,17-18H2,1-2H3,(H,41,45)(H2,36,39,40)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397051
PNG
(US9981975, Example 114)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc4C(=O)CC(C)(C)Cc4n(-c4cccnc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C38H40N8O4/c1-22(2)36(49)44-14-11-24(12-15-44)30-17-27(33-34(39)41-21-42-46(30)33)23-7-9-25(10-8-23)43-35(48)29-16-28-31(18-38(3,4)19-32(28)47)45(37(29)50)26-6-5-13-40-20-26/h5-10,13,16-17,20-22,24H,11-12,14-15,18-19H2,1-4H3,(H,43,48)(H2,39,41,42)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397059
PNG
(US9981975, Example 122)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(CC#N)c(C)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C35H35N9O3/c1-21(2)34(46)42-16-12-24(13-17-42)29-19-27(31-32(37)39-20-40-44(29)31)23-7-9-26(10-8-23)41-33(45)28-18-25(11-14-36)22(3)43(35(28)47)30-6-4-5-15-38-30/h4-10,15,18-21,24H,11-13,16-17H2,1-3H3,(H,41,45)(H2,37,39,40)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397063
PNG
(US9981975, Example 126)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(-c4ncco4)c(C)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C36H35N9O4/c1-21(2)35(47)43-15-11-24(12-16-43)29-19-27(31-32(37)40-20-41-45(29)31)23-7-9-25(10-8-23)42-33(46)28-18-26(34-39-14-17-49-34)22(3)44(36(28)48)30-6-4-5-13-38-30/h4-10,13-14,17-21,24H,11-12,15-16H2,1-3H3,(H,42,46)(H2,37,40,41)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397064
PNG
(US9981975, Example 127)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C(F)F)c(C)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H34F2N8O3/c1-19(2)33(46)42-14-11-22(12-15-42)27-17-25(29-31(37)39-18-40-44(27)29)21-7-9-23(10-8-21)41-32(45)26-16-24(30(35)36)20(3)43(34(26)47)28-6-4-5-13-38-28/h4-10,13,16-19,22,30H,11-12,14-15H2,1-3H3,(H,41,45)(H2,37,39,40)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM397069
PNG
(US9981975, Example 132)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cc(C)c(C)n(-c4cccnc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H36N8O3/c1-20(2)33(44)40-14-11-24(12-15-40)29-17-27(30-31(35)37-19-38-42(29)30)23-7-9-25(10-8-23)39-32(43)28-16-21(3)22(4)41(34(28)45)26-6-5-13-36-18-26/h5-10,13,16-20,24H,11-12,14-15H2,1-4H3,(H,39,43)(H2,35,37,38)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397078
PNG
(US9981975, Example 141)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(C)c(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C36H38N8O3/c1-21(2)36(47)42-16-13-24(14-17-42)30-18-27(32-34(37)39-20-40-44(30)32)23-7-9-25(10-8-23)41-35(46)28-19-43(26-11-12-26)22(3)31(33(28)45)29-6-4-5-15-38-29/h4-10,15,18-21,24,26H,11-14,16-17H2,1-3H3,(H,41,46)(H2,37,39,40)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397081
PNG
(US9981975, Example 144)
Show SMILES CC(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C4CC4)c(=O)n(-c4ccccn4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C34H35N9O4/c1-20(2)32(45)40-15-12-22(13-16-40)27-17-25(29-30(35)37-19-38-43(27)29)21-6-8-23(9-7-21)39-31(44)26-18-41(24-10-11-24)34(47)42(33(26)46)28-5-3-4-14-36-28/h3-9,14,17-20,22,24H,10-13,15-16H2,1-2H3,(H,39,44)(H2,35,37,38)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396945
PNG
(N-{4-[4-Amino-7-(trans-4-hydroxycyclohexyl)pyrrolo...)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)[C@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C30H28N6O3/c31-28-27-25(17-26(36(27)33-18-32-28)20-10-14-23(37)15-11-20)19-8-12-21(13-9-19)34-29(38)24-7-4-16-35(30(24)39)22-5-2-1-3-6-22/h1-9,12-13,16-18,20,23,37H,10-11,14-15H2,(H,34,38)(H2,31,32,33)/t20-,23-
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396956
PNG
(N-{4-[4-Amino-7-(cis-4-hydroxycyclohexyl)pyrrolo[2...)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C30H27FN6O3/c31-25-15-19(35-29(39)23-7-4-14-36(30(23)40)20-5-2-1-3-6-20)10-13-22(25)24-16-26(18-8-11-21(38)12-9-18)37-27(24)28(32)33-17-34-37/h1-7,10,13-18,21,38H,8-9,11-12H2,(H,35,39)(H2,32,33,34)/t18-,21+
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396957
PNG
(N-{4-[4-Amino-7-(cis-4-hydroxycyclohexyl)pyrrolo[2...)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)[C@@H]1CC[C@H](O)CC1
Show InChI InChI=1S/C30H26F2N6O3/c31-18-5-8-20(9-6-18)37-13-1-2-23(30(37)41)29(40)36-19-7-12-22(25(32)14-19)24-15-26(17-3-10-21(39)11-4-17)38-27(24)28(33)34-16-35-38/h1-2,5-9,12-17,21,39H,3-4,10-11H2,(H,36,40)(H2,33,34,35)/t17-,21+
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396960
PNG
(US9981975, Example 22)
Show SMILES CN1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C30H28FN7O2/c1-36-14-11-19(12-15-36)26-17-24(27-28(32)33-18-34-38(26)27)22-10-9-20(16-25(22)31)35-29(39)23-8-5-13-37(30(23)40)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,35,39)(H2,32,33,34)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396964
PNG
(US9981975, Example 26)
Show SMILES CC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C31H28FN7O3/c1-19(40)37-14-11-20(12-15-37)27-17-25(28-29(33)34-18-35-39(27)28)23-10-9-21(16-26(23)32)36-30(41)24-8-5-13-38(31(24)42)22-6-3-2-4-7-22/h2-10,13,16-18,20H,11-12,14-15H2,1H3,(H,36,41)(H2,33,34,35)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396968
PNG
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)[C@@H]1CC[C@@H](CC1)C#N
Show InChI InChI=1S/C31H26FN7O2/c32-26-15-21(37-30(40)24-7-4-14-38(31(24)41)22-5-2-1-3-6-22)12-13-23(26)25-16-27(20-10-8-19(17-33)9-11-20)39-28(25)29(34)35-18-36-39/h1-7,12-16,18-20H,8-11H2,(H,37,40)(H2,34,35,36)/t19-,20+
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396969
PNG
(N-{4-[4-Amino-7-(cis-4-cyanocyclohexyl)pyrrolo[2,1...)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)[C@@H]1CC[C@@H](CC1)C#N
Show InChI InChI=1S/C31H25F2N7O2/c32-20-7-10-22(11-8-20)39-13-1-2-24(31(39)42)30(41)38-21-9-12-23(26(33)14-21)25-15-27(19-5-3-18(16-34)4-6-19)40-28(25)29(35)36-17-37-40/h1-2,7-15,17-19H,3-6H2,(H,38,41)(H2,35,36,37)/t18-,19+
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396976
PNG
(US9981975, Example 38)
Show SMILES COC(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccccc4)c3=O)cc2F)c2c(N)ncnn12
Show InChI InChI=1S/C31H28FN7O4/c1-43-31(42)37-14-11-19(12-15-37)26-17-24(27-28(33)34-18-35-39(26)27)22-10-9-20(16-25(22)32)36-29(40)23-8-5-13-38(30(23)41)21-6-3-2-4-7-21/h2-10,13,16-19H,11-12,14-15H2,1H3,(H,36,40)(H2,33,34,35)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396979
PNG
(US9981975, Example 41)
Show SMILES CS(=O)(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cccn(-c4ccc(F)cc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C30H28FN7O4S/c1-43(41,42)36-15-12-20(13-16-36)26-17-25(27-28(32)33-18-34-38(26)27)19-4-8-22(9-5-19)35-29(39)24-3-2-14-37(30(24)40)23-10-6-21(31)7-11-23/h2-11,14,17-18,20H,12-13,15-16H2,1H3,(H,35,39)(H2,32,33,34)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396990
PNG
(US9981975, Example 52)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3)c12)C1CCN(CCO)CC1
Show InChI InChI=1S/C31H31N7O3/c32-29-28-26(19-27(38(28)34-20-33-29)22-12-15-36(16-13-22)17-18-39)21-8-10-23(11-9-21)35-30(40)25-7-4-14-37(31(25)41)24-5-2-1-3-6-24/h1-11,14,19-20,22,39H,12-13,15-18H2,(H,35,40)(H2,32,33,34)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM396992
PNG
(US9981975, Example 54)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCN(CCO)CC1
Show InChI InChI=1S/C31H30FN7O3/c32-26-17-21(36-30(41)24-7-4-12-38(31(24)42)22-5-2-1-3-6-22)8-9-23(26)25-18-27(39-28(25)29(33)34-19-35-39)20-10-13-37(14-11-20)15-16-40/h1-9,12,17-20,40H,10-11,13-16H2,(H,36,41)(H2,33,34,35)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396992
PNG
(US9981975, Example 54)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccccc5)c4=O)cc3F)c12)C1CCN(CCO)CC1
Show InChI InChI=1S/C31H30FN7O3/c32-26-17-21(36-30(41)24-7-4-12-38(31(24)42)22-5-2-1-3-6-22)8-9-23(26)25-18-27(39-28(25)29(33)34-19-35-39)20-10-13-37(14-11-20)15-16-40/h1-9,12,17-20,40H,10-11,13-16H2,(H,36,41)(H2,33,34,35)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase Mer


(Homo sapiens (Human))
BDBM396993
PNG
(US9981975, Example 55)
Show SMILES Nc1ncnn2c(cc(-c3ccc(NC(=O)c4cccn(-c5ccc(F)cc5)c4=O)cc3F)c12)C1CCN(CCO)CC1
Show InChI InChI=1S/C31H29F2N7O3/c32-20-3-6-22(7-4-20)39-11-1-2-24(31(39)43)30(42)37-21-5-8-23(26(33)16-21)25-17-27(40-28(25)29(34)35-18-36-40)19-9-12-38(13-10-19)14-15-41/h1-8,11,16-19,41H,9-10,12-15H2,(H,37,42)(H2,34,35,36)
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Assay Description
Tyro3, and Mer:The kinase assay buffer contained 50 mM HEPES, pH7.5, 10 mM MgCl2, 1 mM EGTA, 0.01% NP-40 and 2 mM DTT. 0.1 ul test compounds dissolve...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
Tyrosine-protein kinase receptor UFO


(Homo sapiens (Human))
BDBM397000
PNG
(US9981975, Example 62)
Show SMILES CCN(C)C(=O)N1CCC(CC1)c1cc(-c2ccc(NC(=O)c3cn(C(C)C)c(=O)n(-c4ccccc4)c3=O)cc2)c2c(N)ncnn12
Show InChI InChI=1S/C35H39N9O4/c1-5-40(4)34(47)41-17-15-24(16-18-41)29-19-27(30-31(36)37-21-38-44(29)30)23-11-13-25(14-12-23)39-32(45)28-20-42(22(2)3)35(48)43(33(28)46)26-9-7-6-8-10-26/h6-14,19-22,24H,5,15-18H2,1-4H3,(H,39,45)(H2,36,37,38)
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Assay Description
Autophosphorylation of Axl was carried out by incubating the recombinant Axl protein (Life Technologies, PV4275) in buffer containing 50 mM Tris, pH7...


US Patent US9981975 (2018)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%