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Patent code US9987259

Compile Data Set for Download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397112
PNG
(Synthesis of N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES O=C(N[C@H]1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nccs1
Show InChI InChI=1S/C16H18N4O2S/c21-14-2-1-12(9-20(14)16-17-5-8-23-16)15(22)18-13-10-19-6-3-11(13)4-7-19/h1-2,5,8-9,11,13H,3-4,6-7,10H2,(H,18,22)/t13-/m0/s1
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397126
PNG
(Synthesis of N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES CC(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C19H24N4O2S/c1-12(2)16-9-20-19(26-16)23-10-14(3-4-17(23)24)18(25)21-15-11-22-7-5-13(15)6-8-22/h3-4,9-10,12-13,15H,5-8,11H2,1-2H3,(H,21,25)/t15-/m1/s1
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397129
PNG
(Synthesis of N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES CC(C)(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C20H26N4O2S/c1-20(2,3)16-10-21-19(27-16)24-11-14(4-5-17(24)25)18(26)22-15-12-23-8-6-13(15)7-9-23/h4-5,10-11,13,15H,6-9,12H2,1-3H3,(H,22,26)/t15-/m1/s1
PDB

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n/an/an/an/a 750n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397136
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-6-o...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(Cc2ccccc2)s1
Show InChI InChI=1S/C23H24N4O2S/c28-21-7-6-18(22(29)25-20-15-26-10-8-17(20)9-11-26)14-27(21)23-24-13-19(30-23)12-16-4-2-1-3-5-16/h1-7,13-14,17,20H,8-12,15H2,(H,25,29)
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397137
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(...)
Show SMILES Cc1csc(n1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C17H20N4O2S/c1-11-10-24-17(18-11)21-8-13(2-3-15(21)22)16(23)19-14-9-20-6-4-12(14)5-7-20/h2-3,8,10,12,14H,4-7,9H2,1H3,(H,19,23)
PDB

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n/an/an/an/a>1.00E+3n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397139
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-1-[...)
Show SMILES Cc1nnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C16H19N5O2S/c1-10-18-19-16(24-10)21-8-12(2-3-14(21)22)15(23)17-13-9-20-6-4-11(13)5-7-20/h2-3,8,11,13H,4-7,9H2,1H3,(H,17,23)
PDB

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n/an/an/an/a>1.00E+3n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397130
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(s1)C1CCCC1
Show InChI InChI=1S/C21H26N4O2S/c26-19-6-5-16(20(27)23-17-13-24-9-7-14(17)8-10-24)12-25(19)21-22-11-18(28-21)15-3-1-2-4-15/h5-6,11-12,14-15,17H,1-4,7-10,13H2,(H,23,27)
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397135
PNG
(Synthesis of N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES Clc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C16H17ClN4O2S/c17-13-7-18-16(24-13)21-8-11(1-2-14(21)22)15(23)19-12-9-20-5-3-10(12)4-6-20/h1-2,7-8,10,12H,3-6,9H2,(H,19,23)/t12-/m1/s1
PDB

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n/an/an/an/a>1.00E+3n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397138
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nc2ccccc2s1
Show InChI InChI=1S/C20H20N4O2S/c25-18-6-5-14(19(26)21-16-12-23-9-7-13(16)8-10-23)11-24(18)20-22-15-3-1-2-4-17(15)27-20/h1-6,11,13,16H,7-10,12H2,(H,21,26)
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397122
PNG
(Synthesis of N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES CCc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C18H22N4O2S/c1-2-14-9-19-18(25-14)22-10-13(3-4-16(22)23)17(24)20-15-11-21-7-5-12(15)6-8-21/h3-4,9-10,12,15H,2,5-8,11H2,1H3,(H,20,24)/t15-/m1/s1
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397127
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(...)
Show SMILES CC(C)(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C20H26N4O2S/c1-20(2,3)16-10-21-19(27-16)24-11-14(4-5-17(24)25)18(26)22-15-12-23-8-6-13(15)7-9-23/h4-5,10-11,13,15H,6-9,12H2,1-3H3,(H,22,26)
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397134
PNG
(Synthesis of N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES Clc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C16H17ClN4O2S/c17-13-7-18-16(24-13)21-8-11(1-2-14(21)22)15(23)19-12-9-20-5-3-10(12)4-6-20/h1-2,7-8,10,12H,3-6,9H2,(H,19,23)/t12-/m0/s1
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397111
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-6-o...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nccs1
Show InChI InChI=1S/C16H18N4O2S/c21-14-2-1-12(9-20(14)16-17-5-8-23-16)15(22)18-13-10-19-6-3-11(13)4-7-19/h1-2,5,8-9,11,13H,3-4,6-7,10H2,(H,18,22)
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397115
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-6-o...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ccc(cn1)-c1ccccc1
Show InChI InChI=1S/C24H24N4O2/c29-23-9-7-20(24(30)26-21-16-27-12-10-18(21)11-13-27)15-28(23)22-8-6-19(14-25-22)17-4-2-1-3-5-17/h1-9,14-15,18,21H,10-13,16H2,(H,26,30)
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397117
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(...)
Show SMILES Cc1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C17H20N4O2S/c1-11-8-18-17(24-11)21-9-13(2-3-15(21)22)16(23)19-14-10-20-6-4-12(14)5-7-20/h2-3,8-9,12,14H,4-7,10H2,1H3,(H,19,23)
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397118
PNG
(Synthesis of N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES Cc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C17H20N4O2S/c1-11-8-18-17(24-11)21-9-13(2-3-15(21)22)16(23)19-14-10-20-6-4-12(14)5-7-20/h2-3,8-9,12,14H,4-7,10H2,1H3,(H,19,23)/t14-/m0/s1
PDB

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n/an/an/an/a<100n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397119
PNG
(Synthesis of N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES Cc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@@H]1CN2CCC1CC2
Show InChI InChI=1S/C17H20N4O2S/c1-11-8-18-17(24-11)21-9-13(2-3-15(21)22)16(23)19-14-10-20-6-4-12(14)5-7-20/h2-3,8-9,12,14H,4-7,10H2,1H3,(H,19,23)/t14-/m1/s1
PDB

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n/an/an/an/a 750n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397123
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-6-o...)
Show SMILES CCCc1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C19H24N4O2S/c1-2-3-15-10-20-19(26-15)23-11-14(4-5-17(23)24)18(25)21-16-12-22-8-6-13(16)7-9-22/h4-5,10-11,13,16H,2-3,6-9,12H2,1H3,(H,21,25)
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397131
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(s1)C1CCCCC1
Show InChI InChI=1S/C22H28N4O2S/c27-20-7-6-17(21(28)24-18-14-25-10-8-15(18)9-11-25)13-26(20)22-23-12-19(29-22)16-4-2-1-3-5-16/h6-7,12-13,15-16,18H,1-5,8-11,14H2,(H,24,28)
PDB

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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397132
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1ncc(s1)-c1ccccc1
Show InChI InChI=1S/C22H22N4O2S/c27-20-7-6-17(21(28)24-18-14-25-10-8-15(18)9-11-25)13-26(20)22-23-12-19(29-22)16-4-2-1-3-5-16/h1-7,12-13,15,18H,8-11,14H2,(H,24,28)
PDB

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n/an/an/an/a 750n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397133
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(...)
Show SMILES Clc1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C16H17ClN4O2S/c17-13-7-18-16(24-13)21-8-11(1-2-14(21)22)15(23)19-12-9-20-5-3-10(12)4-6-20/h1-2,7-8,10,12H,3-6,9H2,(H,19,23)
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n/an/an/an/a<100n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397140
PNG
(Synthesis of (1-azabicyclo[2.2.2]octan-3-yl)-1-[5-...)
Show SMILES Cc1cnc(s1)-n1cc(ccc1=O)C(=O)OC1CN2CCC1CC2
Show InChI InChI=1S/C17H19N3O3S/c1-11-8-18-17(24-11)20-9-13(2-3-15(20)21)16(22)23-14-10-19-6-4-12(14)5-7-19/h2-3,8-9,12,14H,4-7,10H2,1H3
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n/an/an/an/a>1.00E+3n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397113
PNG
(Synthesis of N-[(3S)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES O=C(N[C@@H]1CN2CCC1CC2)c1ccc(=O)n(c1)-c1nccs1
Show InChI InChI=1S/C16H18N4O2S/c21-14-2-1-12(9-20(14)16-17-5-8-23-16)15(22)18-13-10-19-6-3-11(13)4-7-19/h1-2,5,8-9,11,13H,3-4,6-7,10H2,(H,18,22)/t13-/m1/s1
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397114
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(...)
Show SMILES Clc1ccc(nc1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C18H19ClN4O2/c19-14-2-3-16(20-9-14)23-10-13(1-4-17(23)24)18(25)21-15-11-22-7-5-12(15)6-8-22/h1-4,9-10,12,15H,5-8,11H2,(H,21,25)
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n/an/an/an/a>1.00E+3n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397120
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-1-(...)
Show SMILES CCc1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C18H22N4O2S/c1-2-14-9-19-18(25-14)22-10-13(3-4-16(22)23)17(24)20-15-11-21-7-5-12(15)6-8-21/h3-4,9-10,12,15H,2,5-8,11H2,1H3,(H,20,24)
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397121
PNG
(Synthesis of N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES CCc1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C18H22N4O2S/c1-2-14-9-19-18(25-14)22-10-13(3-4-16(22)23)17(24)20-15-11-21-7-5-12(15)6-8-21/h3-4,9-10,12,15H,2,5-8,11H2,1H3,(H,20,24)/t15-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397124
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-6-o...)
Show SMILES CC(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C19H24N4O2S/c1-12(2)16-9-20-19(26-16)23-10-14(3-4-17(23)24)18(25)21-15-11-22-7-5-13(15)6-8-22/h3-4,9-10,12-13,15H,5-8,11H2,1-2H3,(H,21,25)
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397141
PNG
(US9987259, Example 46)
Show SMILES CC(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)OC1CN2CCC1CC2
Show InChI InChI=1S/C19H23N3O3S/c1-12(2)16-9-20-19(26-16)22-10-14(3-4-17(22)23)18(24)25-15-11-21-7-5-13(15)6-8-21/h3-4,9-10,12-13,15H,5-8,11H2,1-2H3
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n/an/an/an/a>1.00E+3n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397116
PNG
(Synthesis of N-(1-azabicyclo[2.2.2]octan-3-yl)-6-o...)
Show SMILES O=C(NC1CN2CCC1CC2)c1ccc(=O)n(c1)-c1cc(no1)-c1ccccc1
Show InChI InChI=1S/C22H22N4O3/c27-20-7-6-17(22(28)23-19-14-25-10-8-16(19)9-11-25)13-26(20)21-12-18(24-29-21)15-4-2-1-3-5-15/h1-7,12-13,16,19H,8-11,14H2,(H,23,28)
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n/an/an/an/a>1.00E+3n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397125
PNG
(Synthesis of N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES CC(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C19H24N4O2S/c1-12(2)16-9-20-19(26-16)23-10-14(3-4-17(23)24)18(25)21-15-11-22-7-5-13(15)6-8-22/h3-4,9-10,12-13,15H,5-8,11H2,1-2H3,(H,21,25)/t15-/m0/s1
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n/an/an/an/a<100n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
Neuronal acetylcholine receptor subunit alpha-7


(Homo sapiens (Human))
BDBM397128
PNG
(Synthesis of N-[(3R)-1-azabicyclo[2.2.2]octan-3-yl...)
Show SMILES CC(C)(C)c1cnc(s1)-n1cc(ccc1=O)C(=O)N[C@H]1CN2CCC1CC2
Show InChI InChI=1S/C20H26N4O2S/c1-20(2,3)16-10-21-19(27-16)24-11-14(4-5-17(24)25)18(26)22-15-12-23-8-6-13(15)7-9-23/h4-5,10-11,13,15H,6-9,12H2,1-3H3,(H,22,26)/t15-/m0/s1
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n/an/an/an/a 300n/an/an/an/a



SK BIOPHARMACEUTICALS CO., LTD.

US Patent


Assay Description
On the day of the assay, after removal of the growth media, the cells were washed once with an assay buffer (7 mM Tris-Cl, 20 mM HEPES, 20 mM NaCl, 5...


US Patent US9987259 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%