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Patent code US9987278

Compile Data Set for Download or QSAR
Found 41 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397407
PNG
(US9987278, Compound Reference 17)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCC(CC)NC(=O)CNC(=O)C=C
Show InChI InChI=1S/C25H36N8O3/c1-4-11-27-23-20(16-31-25(33-23)29-14-9-18-7-12-26-13-8-18)24(36)28-15-10-19(5-2)32-22(35)17-30-21(34)6-3/h6-8,12-13,16,19H,3-5,9-11,14-15,17H2,1-2H3,(H,28,36)(H,30,34)(H,32,35)(H2,27,29,31,33)
PDB

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US Patent
n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397419
PNG
(US9987278, Compound Reference 29)
Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C#Cc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C32H38N8O3/c1-6-18-34-30-25(21-35-32(38-30)37-26-16-14-24(15-17-26)29(33)42)13-12-23-9-7-10-27(20-23)36-31(43)22(2)40(5)28(41)11-8-19-39(3)4/h7-11,14-17,20-22H,6,18-19H2,1-5H3,(H2,33,42)(H,36,43)(H2,34,35,37,38)/b11-8+/t22-/m0/s1
PDB

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UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397410
PNG
(US9987278, Compound Reference 20)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCC(CC)NC(=O)CN(C)C(=O)\C=C\CN(C)C
Show InChI InChI=1S/C29H45N9O3/c1-6-14-31-27-24(20-34-29(36-27)33-17-12-22-10-15-30-16-11-22)28(41)32-18-13-23(7-2)35-25(39)21-38(5)26(40)9-8-19-37(3)4/h8-11,15-16,20,23H,6-7,12-14,17-19,21H2,1-5H3,(H,32,41)(H,35,39)(H2,31,33,34,36)/b9-8+
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US Patent
n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397280
PNG
(US9987278, Compound Reference 2)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)C=C)c1
Show InChI InChI=1S/C26H30N8O3/c1-3-11-28-24-21(16-31-26(34-24)29-14-10-18-8-12-27-13-9-18)25(37)33-20-7-5-6-19(15-20)32-23(36)17-30-22(35)4-2/h4-9,12-13,15-16H,2-3,10-11,14,17H2,1H3,(H,30,35)(H,32,36)(H,33,37)(H2,28,29,31,34)
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n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397431
PNG
(US9987278, Compound Reference 41)
Show SMILES CNc1nc(Nc2ccc(F)cc2)ncc1C#C[C@@H]1C[C@@H](C1)NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C
Show InChI InChI=1S/C27H34FN7O2/c1-18(35(5)24(36)7-6-14-34(3)4)26(37)31-23-15-19(16-23)8-9-20-17-30-27(33-25(20)29-2)32-22-12-10-21(28)11-13-22/h6-7,10-13,17-19,23H,14-16H2,1-5H3,(H,31,37)(H2,29,30,32,33)/b7-6+/t18-,19-,23+/m0/s1
PDB

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n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397417
PNG
(US9987278, Compound Reference 27)
Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C31H39N9O4/c1-6-16-33-28-25(19-34-31(38-28)37-22-14-12-21(13-15-22)27(32)42)30(44)36-24-10-7-9-23(18-24)35-29(43)20(2)40(5)26(41)11-8-17-39(3)4/h7-15,18-20H,6,16-17H2,1-5H3,(H2,32,42)(H,35,43)(H,36,44)(H2,33,34,37,38)/b11-8+/t20-/m0/s1
PDB

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n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397414
PNG
(US9987278, Compound Reference 24)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)NC(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C30H39N9O3/c1-5-14-32-27-25(20-34-30(38-27)33-17-13-22-11-15-31-16-12-22)29(42)37-24-9-6-8-23(19-24)36-28(41)21(2)35-26(40)10-7-18-39(3)4/h6-12,15-16,19-21H,5,13-14,17-18H2,1-4H3,(H,35,40)(H,36,41)(H,37,42)(H2,32,33,34,38)/b10-7+/t21-/m0/s1
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n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397408
PNG
(US9987278, Compound Reference 18)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCC(CC)NC(=O)CNC(=O)\C=C\CN(C)C
Show InChI InChI=1S/C28H43N9O3/c1-5-13-30-26-23(19-34-28(36-26)32-16-11-21-9-14-29-15-10-21)27(40)31-17-12-22(6-2)35-25(39)20-33-24(38)8-7-18-37(3)4/h7-10,14-15,19,22H,5-6,11-13,16-18,20H2,1-4H3,(H,31,40)(H,33,38)(H,35,39)(H2,30,32,34,36)/b8-7+
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n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397406
PNG
(US9987278, Compound Reference 16)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)NC(=O)C=C)c1
Show InChI InChI=1S/C27H32N8O3/c1-4-12-29-24-22(17-31-27(35-24)30-15-11-19-9-13-28-14-10-19)26(38)34-21-8-6-7-20(16-21)33-25(37)18(3)32-23(36)5-2/h5-10,13-14,16-18H,2,4,11-12,15H2,1,3H3,(H,32,36)(H,33,37)(H,34,38)(H2,29,30,31,35)/t18-/m0/s1
PDB

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US Patent
n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397395
PNG
(US9987278, Compound Reference 5)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C29H37N9O3/c1-4-13-31-27-24(19-34-29(37-27)32-16-12-21-10-14-30-15-11-21)28(41)36-23-8-5-7-22(18-23)35-26(40)20-33-25(39)9-6-17-38(2)3/h5-11,14-15,18-19H,4,12-13,16-17,20H2,1-3H3,(H,33,39)(H,35,40)(H,36,41)(H2,31,32,34,37)/b9-6+
PDB

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PC cid
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UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397430
PNG
(US9987278, Compound Reference 40)
Show SMILES C[C@H](N(C)C(=O)\C=C\CN(C)C)C(=O)N[C@H]1C[C@H](C1)C#Cc1cnc(Nc2ccc(F)cc2)nc1NC1CC1
Show InChI InChI=1S/C29H36FN7O2/c1-19(37(4)26(38)6-5-15-36(2)3)28(39)33-25-16-20(17-25)7-8-21-18-31-29(35-27(21)32-23-13-14-23)34-24-11-9-22(30)10-12-24/h5-6,9-12,18-20,23,25H,13-17H2,1-4H3,(H,33,39)(H2,31,32,34,35)/b6-5+/t19-,20-,25+/m0/s1
PDB

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n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397411
PNG
(US9987278, Compound Reference 21)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)\C=C\CN2CC(C)NC(C)C2)c1
Show InChI InChI=1S/C33H44N10O3/c1-4-13-35-31-28(19-38-33(42-31)36-16-12-25-10-14-34-15-11-25)32(46)41-27-8-5-7-26(18-27)40-30(45)20-37-29(44)9-6-17-43-21-23(2)39-24(3)22-43/h5-11,14-15,18-19,23-24,39H,4,12-13,16-17,20-22H2,1-3H3,(H,37,44)(H,40,45)(H,41,46)(H2,35,36,38,42)/b9-6+
PDB

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UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397418
PNG
(US9987278, Compound Reference 28)
Show SMILES CCCNc1nc(Nc2ccc3cnccc3c2)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C33H39N9O3/c1-6-15-35-30-28(21-36-33(40-30)39-27-13-12-24-20-34-16-14-23(24)18-27)32(45)38-26-10-7-9-25(19-26)37-31(44)22(2)42(5)29(43)11-8-17-41(3)4/h7-14,16,18-22H,6,15,17H2,1-5H3,(H,37,44)(H,38,45)(H2,35,36,39,40)/b11-8+/t22-/m0/s1
PDB

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PC cid
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US Patent
n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397416
PNG
(US9987278, Compound Reference 26)
Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C(=O)NC1CCCC(C1)NC(=O)CN(C)C(=O)\C=C\CN(C)C
Show InChI InChI=1S/C30H43N9O4/c1-5-15-32-28-24(18-33-30(37-28)36-21-13-11-20(12-14-21)27(31)42)29(43)35-23-9-6-8-22(17-23)34-25(40)19-39(4)26(41)10-7-16-38(2)3/h7,10-14,18,22-23H,5-6,8-9,15-17,19H2,1-4H3,(H2,31,42)(H,34,40)(H,35,43)(H2,32,33,36,37)/b10-7+
PDB

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PC cid
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US Patent
n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397400
PNG
(US9987278, Compound Reference 10)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CN(C)C(=O)C=C)c1
Show InChI InChI=1S/C27H32N8O3/c1-4-12-29-25-22(17-31-27(34-25)30-15-11-19-9-13-28-14-10-19)26(38)33-21-8-6-7-20(16-21)32-23(36)18-35(3)24(37)5-2/h5-10,13-14,16-17H,2,4,11-12,15,18H2,1,3H3,(H,32,36)(H,33,38)(H2,29,30,31,34)
PDB

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UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397412
PNG
(US9987278, Compound Reference 22)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1ccc(C)c(NC(=O)CNC(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C30H39N9O3/c1-5-13-32-28-24(19-35-30(38-28)33-16-12-22-10-14-31-15-11-22)29(42)36-23-9-8-21(2)25(18-23)37-27(41)20-34-26(40)7-6-17-39(3)4/h6-11,14-15,18-19H,5,12-13,16-17,20H2,1-4H3,(H,34,40)(H,36,42)(H,37,41)(H2,32,33,35,38)/b7-6+
PDB

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n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397427
PNG
(US9987278, Compound Reference 37)
Show SMILES CCCN(C)c1nc(NCCc2ccncc2)ncc1C#Cc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C33H42N8O2/c1-7-21-40(5)31-28(24-36-33(38-31)35-20-17-26-15-18-34-19-16-26)14-13-27-10-8-11-29(23-27)37-32(43)25(2)41(6)30(42)12-9-22-39(3)4/h8-12,15-16,18-19,23-25H,7,17,20-22H2,1-6H3,(H,37,43)(H,35,36,38)/b12-9+/t25-/m0/s1
PDB

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n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397413
PNG
(US9987278, Compound Reference 23)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCCNC(=O)CNC(=O)\C=C\CN(C)C
Show InChI InChI=1S/C26H39N9O3/c1-4-11-29-24-21(18-33-26(34-24)31-16-10-20-8-14-27-15-9-20)25(38)30-13-6-12-28-23(37)19-32-22(36)7-5-17-35(2)3/h5,7-9,14-15,18H,4,6,10-13,16-17,19H2,1-3H3,(H,28,37)(H,30,38)(H,32,36)(H2,29,31,33,34)/b7-5+
PDB

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PC sid
UniChem
US Patent
n/an/a<1n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397422
PNG
(US9987278, Compound Reference 32)
Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN2CC(O)C2)c1
Show InChI InChI=1S/C32H39N9O5/c1-4-14-34-29-26(17-35-32(39-29)38-22-12-10-21(11-13-22)28(33)44)31(46)37-24-8-5-7-23(16-24)36-30(45)20(2)40(3)27(43)9-6-15-41-18-25(42)19-41/h5-13,16-17,20,25,42H,4,14-15,18-19H2,1-3H3,(H2,33,44)(H,36,45)(H,37,46)(H2,34,35,38,39)/b9-6+/t20-/m0/s1
PDB

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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397428
PNG
(US9987278, Compound Reference 38)
Show SMILES CCCNc1nc(Nc2ccc(cc2)C#N)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C
Show InChI InChI=1S/C29H38N8O2/c1-6-17-31-27-24(21-33-29(35-27)34-25-15-13-23(20-30)14-16-25)11-8-7-9-18-32-28(39)22(2)37(5)26(38)12-10-19-36(3)4/h10,12-16,21-22H,6-7,9,17-19H2,1-5H3,(H,32,39)(H2,31,33,34,35)/b12-10+/t22-/m0/s1
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397429
PNG
(US9987278, Compound Reference 39)
Show SMILES CCCNc1nc(Nc2cccc(F)c2)ncc1C#C[C@@H]1C[C@@H](C1)NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C
Show InChI InChI=1S/C29H38FN7O2/c1-6-14-31-27-22(19-32-29(35-27)34-24-10-7-9-23(30)18-24)13-12-21-16-25(17-21)33-28(39)20(2)37(5)26(38)11-8-15-36(3)4/h7-11,18-21,25H,6,14-17H2,1-5H3,(H,33,39)(H2,31,32,34,35)/b11-8+/t20-,21-,25+/m0/s1
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397404
PNG
(US9987278, Compound Reference 14)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)\C=C\CN2CCN(CCO)CC2)c1
Show InChI InChI=1S/C33H44N10O4/c1-2-11-35-31-28(23-38-33(41-31)36-14-10-25-8-12-34-13-9-25)32(47)40-27-6-3-5-26(22-27)39-30(46)24-37-29(45)7-4-15-42-16-18-43(19-17-42)20-21-44/h3-9,12-13,22-23,44H,2,10-11,14-21,24H2,1H3,(H,37,45)(H,39,46)(H,40,47)(H2,35,36,38,41)/b7-4+
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397424
PNG
(US9987278, Compound Reference 34)
Show SMILES CCCNc1nc(Nc2cccc(F)c2)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C
Show InChI InChI=1S/C28H38FN7O2/c1-6-16-30-26-22(20-32-28(34-26)33-24-14-10-13-23(29)19-24)12-8-7-9-17-31-27(38)21(2)36(5)25(37)15-11-18-35(3)4/h10-11,13-15,19-21H,6-7,9,16-18H2,1-5H3,(H,31,38)(H2,30,32,33,34)/b15-11+/t21-/m0/s1
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397409
PNG
(US9987278, Compound Reference 19)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCC(CC)NC(=O)CN(C)C(=O)C=C
Show InChI InChI=1S/C26H38N8O3/c1-5-12-28-24-21(17-31-26(33-24)30-15-10-19-8-13-27-14-9-19)25(37)29-16-11-20(6-2)32-22(35)18-34(4)23(36)7-3/h7-9,13-14,17,20H,3,5-6,10-12,15-16,18H2,1-2,4H3,(H,29,37)(H,32,35)(H2,28,30,31,33)
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397415
PNG
(US9987278, Compound Reference 25)
Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C(=O)NCCCNC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C
Show InChI InChI=1S/C28H41N9O4/c1-6-14-30-25-22(18-33-28(35-25)34-21-12-10-20(11-13-21)24(29)39)27(41)32-16-8-15-31-26(40)19(2)37(5)23(38)9-7-17-36(3)4/h7,9-13,18-19H,6,8,14-17H2,1-5H3,(H2,29,39)(H,31,40)(H,32,41)(H2,30,33,34,35)/b9-7+/t19-/m0/s1
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397420
PNG
(US9987278, Compound Reference 30)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C31H41N9O3/c1-6-15-33-28-26(21-35-31(38-28)34-18-14-23-12-16-32-17-13-23)30(43)37-25-10-7-9-24(20-25)36-29(42)22(2)40(5)27(41)11-8-19-39(3)4/h7-13,16-17,20-22H,6,14-15,18-19H2,1-5H3,(H,36,42)(H,37,43)(H2,33,34,35,38)/b11-8+/t22-/m0/s1
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397397
PNG
(US9987278, Compound Reference 7)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCCCNC(=O)CNC(=O)C=C
Show InChI InChI=1S/C23H32N8O3/c1-3-9-26-21-18(15-30-23(31-21)28-14-8-17-6-12-24-13-7-17)22(34)27-11-5-10-25-20(33)16-29-19(32)4-2/h4,6-7,12-13,15H,2-3,5,8-11,14,16H2,1H3,(H,25,33)(H,27,34)(H,29,32)(H2,26,28,30,31)
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397399
PNG
(US9987278, Compound Reference 9)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)C(C)(C)NC(=O)C=C)c1
Show InChI InChI=1S/C28H34N8O3/c1-5-13-30-24-22(18-32-27(35-24)31-16-12-19-10-14-29-15-11-19)25(38)33-20-8-7-9-21(17-20)34-26(39)28(3,4)36-23(37)6-2/h6-11,14-15,17-18H,2,5,12-13,16H2,1,3-4H3,(H,33,38)(H,34,39)(H,36,37)(H2,30,31,32,35)
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397425
PNG
(US9987278, Compound Reference 35)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C#Cc1cccc(NC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C32H40N8O2/c1-6-17-34-30-27(23-36-32(38-30)35-20-16-25-14-18-33-19-15-25)13-12-26-9-7-10-28(22-26)37-31(42)24(2)40(5)29(41)11-8-21-39(3)4/h7-11,14-15,18-19,22-24H,6,16-17,20-21H2,1-5H3,(H,37,42)(H2,34,35,36,38)/b11-8+/t24-/m0/s1
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397426
PNG
(US9987278, Compound Reference 36)
Show SMILES C[C@H](N(C)C(=O)\C=C\CN(C)C)C(=O)Nc1cccc(c1)C#Cc1cnc(NCCc2ccncc2)nc1N1CCOCC1
Show InChI InChI=1S/C33H40N8O3/c1-25(40(4)30(42)9-6-18-39(2)3)32(43)37-29-8-5-7-27(23-29)10-11-28-24-36-33(35-17-14-26-12-15-34-16-13-26)38-31(28)41-19-21-44-22-20-41/h5-9,12-13,15-16,23-25H,14,17-22H2,1-4H3,(H,37,43)(H,35,36,38)/b9-6+/t25-/m0/s1
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397421
PNG
(US9987278, Compound Reference 31)
Show SMILES CCCNc1nc(Nc2ccc(cc2)C(N)=O)ncc1C#Cc1cccc(NCCNC(=O)\C=C\CN(C)C)c1
Show InChI InChI=1S/C30H36N8O2/c1-4-16-34-29-24(21-35-30(37-29)36-25-14-12-23(13-15-25)28(31)40)11-10-22-7-5-8-26(20-22)32-17-18-33-27(39)9-6-19-38(2)3/h5-9,12-15,20-21,32H,4,16-19H2,1-3H3,(H2,31,40)(H,33,39)(H2,34,35,36,37)/b9-6+
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397403
PNG
(US9987278, Compound Reference 13)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)\C=C\CN2CCOCC2)c1
Show InChI InChI=1S/C31H39N9O4/c1-2-11-33-29-26(21-36-31(39-29)34-14-10-23-8-12-32-13-9-23)30(43)38-25-6-3-5-24(20-25)37-28(42)22-35-27(41)7-4-15-40-16-18-44-19-17-40/h3-9,12-13,20-21H,2,10-11,14-19,22H2,1H3,(H,35,41)(H,37,42)(H,38,43)(H2,33,34,36,39)/b7-4+
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397405
PNG
(US9987278, Compound Reference 15)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NCCNC(=O)C=C)c1
Show InChI InChI=1S/C26H32N8O2/c1-3-11-30-24-22(18-32-26(34-24)31-14-10-19-8-12-27-13-9-19)25(36)33-21-7-5-6-20(17-21)28-15-16-29-23(35)4-2/h4-9,12-13,17-18,28H,2-3,10-11,14-16H2,1H3,(H,29,35)(H,33,36)(H2,30,31,32,34)
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397396
PNG
(US9987278, Compound Reference 6)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(OCCNC(=O)C=C)c1
Show InChI InChI=1S/C26H31N7O3/c1-3-11-29-24-22(18-31-26(33-24)30-14-10-19-8-12-27-13-9-19)25(35)32-20-6-5-7-21(17-20)36-16-15-28-23(34)4-2/h4-9,12-13,17-18H,2-3,10-11,14-16H2,1H3,(H,28,34)(H,32,35)(H2,29,30,31,33)
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397401
PNG
(US9987278, Compound Reference 11)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(c1)N(C)C(=O)CNC(=O)C=C
Show InChI InChI=1S/C27H32N8O3/c1-4-12-29-25-22(17-32-27(34-25)30-15-11-19-9-13-28-14-10-19)26(38)33-20-7-6-8-21(16-20)35(3)24(37)18-31-23(36)5-2/h5-10,13-14,16-17H,2,4,11-12,15,18H2,1,3H3,(H,31,36)(H,33,38)(H2,29,30,32,34)
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397398
PNG
(US9987278, Compound Reference 8)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)[C@@H](C)NC(=O)C=C)c1
Show InChI InChI=1S/C27H32N8O3/c1-4-12-29-24-22(17-31-27(35-24)30-15-11-19-9-13-28-14-10-19)26(38)34-21-8-6-7-20(16-21)33-25(37)18(3)32-23(36)5-2/h5-10,13-14,16-18H,2,4,11-12,15H2,1,3H3,(H,32,36)(H,33,37)(H,34,38)(H2,29,30,31,35)/t18-/m1/s1
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397423
PNG
(US9987278, Compound Reference 33)
Show SMILES CCCNc1nc(Nc2cccc(c2)C#N)ncc1C#CCCCNC(=O)[C@H](C)N(C)C(=O)\C=C\CN(C)C
Show InChI InChI=1S/C29H38N8O2/c1-6-16-31-27-24(21-33-29(35-27)34-25-14-10-12-23(19-25)20-30)13-8-7-9-17-32-28(39)22(2)37(5)26(38)15-11-18-36(3)4/h10-12,14-15,19,21-22H,6-7,9,16-18H2,1-5H3,(H,32,39)(H2,31,33,34,35)/b15-11+/t22-/m0/s1
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397394
PNG
(US9987278, Compound Reference 4)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cc(Cl)cc(NC(=O)CNC(=O)C=C)c1
Show InChI InChI=1S/C26H29ClN8O3/c1-3-8-29-24-21(15-32-26(35-24)30-11-7-17-5-9-28-10-6-17)25(38)34-20-13-18(27)12-19(14-20)33-23(37)16-31-22(36)4-2/h4-6,9-10,12-15H,2-3,7-8,11,16H2,1H3,(H,31,36)(H,33,37)(H,34,38)(H2,29,30,32,35)
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FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397232
PNG
(US9987278, Compound Reference 1)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCc1cccc(NC(=O)CNC(=O)C=C)c1
Show InChI InChI=1S/C27H32N8O3/c1-3-11-29-25-22(17-33-27(35-25)30-14-10-19-8-12-28-13-9-19)26(38)32-16-20-6-5-7-21(15-20)34-24(37)18-31-23(36)4-2/h4-9,12-13,15,17H,2-3,10-11,14,16,18H2,1H3,(H,31,36)(H,32,38)(H,34,37)(H2,29,30,33,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397402
PNG
(US9987278, Compound Reference 12)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)Nc1cccc(NC(=O)CNC(=O)\C=C\CN2CCN(C)CC2)c1
Show InChI InChI=1S/C32H42N10O3/c1-3-12-34-30-27(22-37-32(40-30)35-15-11-24-9-13-33-14-10-24)31(45)39-26-7-4-6-25(21-26)38-29(44)23-36-28(43)8-5-16-42-19-17-41(2)18-20-42/h4-10,13-14,21-22H,3,11-12,15-20,23H2,1-2H3,(H,36,43)(H,38,44)(H,39,45)(H2,34,35,37,40)/b8-5+
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
FLT3(D835Y)


(Homo sapiens (Human))
BDBM397393
PNG
(US9987278, Compound Reference 3)
Show SMILES CCCNc1nc(NCCc2ccncc2)ncc1C(=O)NCc1ccccc1NC(=O)CNC(=O)C=C
Show InChI InChI=1S/C27H32N8O3/c1-3-12-29-25-21(17-33-27(35-25)30-15-11-19-9-13-28-14-10-19)26(38)32-16-20-7-5-6-8-22(20)34-24(37)18-31-23(36)4-2/h4-10,13-14,17H,2-3,11-12,15-16,18H2,1H3,(H,31,36)(H,32,38)(H,34,37)(H2,29,30,33,35)
PDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.5n/an/an/an/an/an/a



FUJIFILM Corporation

US Patent


Assay Description
Quizartinib (Ambit Biosciences Corporation) was used as Reference Compound 1.6 μL (0.75 ng) of a mutant FLT3 protein (FLT3 D835Y, Life Technolog...


US Patent US9987278 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%