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Patent code US9994546

Compile Data Set for Download or QSAR
Found 130 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397518
PNG
(US9994546, Example 17 | [1-Methyl-4-(3-{[(trans-2-...)
Show SMILES CN1CCC(CC#N)(CC1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C21H30N4/c1-24-11-8-21(7-10-22,9-12-24)25-15-17(16-25)14-23-20-13-19(20)18-5-3-2-4-6-18/h2-6,17,19-20,23H,7-9,11-16H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397525
PNG
(4-(Cyanomethyl)-N-isopropyl-4-(3-{[(trans-2-phenyl...)
Show SMILES CC(C)NC(=O)N1CCC(CC#N)(CC1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C24H35N5O/c1-18(2)27-23(30)28-12-9-24(8-11-25,10-13-28)29-16-19(17-29)15-26-22-14-21(22)20-6-4-3-5-7-20/h3-7,18-19,21-22,26H,8-10,12-17H2,1-2H3,(H,27,30)
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397536
PNG
(4-[3-(Cyanomethyl)-3-(4-{[(trans-2-phenylcycloprop...)
Show SMILES CC(C)NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C30H37F2N5O/c1-20(2)35-29(38)24-14-26(32)28(16-25(24)31)36-18-30(19-36,10-11-33)37-12-8-21(9-13-37)17-34-27-15-23(27)22-6-4-3-5-7-22/h3-7,14,16,20-21,23,27,34H,8-10,12-13,15,17-19H2,1-2H3,(H,35,38)
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397537
PNG
(US9994546, Example 36 | {3-(4-{[(trans-2-Phenylcyc...)
Show SMILES FC(F)(F)c1cccnc1N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C26H30F3N5/c27-26(28,29)22-7-4-12-31-24(22)33-17-25(18-33,10-11-30)34-13-8-19(9-14-34)16-32-23-15-21(23)20-5-2-1-3-6-20/h1-7,12,19,21,23,32H,8-10,13-18H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397544
PNG
(N-(3-Chloro-2-fluorophenyl)-3-(cyanomethyl)-3-(4-{...)
Show SMILES Fc1c(Cl)cccc1NC(=O)N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C27H31ClFN5O/c28-22-7-4-8-23(25(22)29)32-26(35)33-17-27(18-33,11-12-30)34-13-9-19(10-14-34)16-31-24-15-21(24)20-5-2-1-3-6-20/h1-8,19,21,24,31H,9-11,13-18H2,(H,32,35)
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397584
PNG
(US9994546, Example 83 | [1-[(cis-4-hydroxycyclohex...)
Show SMILES O[C@H]1CC[C@H](CC1)C(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C26H36N4O2/c27-13-12-26(17-29(18-26)25(32)20-6-8-22(31)9-7-20)30-14-10-21(11-15-30)28-24-16-23(24)19-4-2-1-3-5-19/h1-5,20-24,28,31H,6-12,14-18H2/t20-,22+,23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397596
PNG
(US9994546, Example 95 | methyl 3-[2-(methylamino)-...)
Show SMILES CNC(=O)CC1(CN(C1)C(=O)OC)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C22H32N4O3/c1-23-20(27)13-22(14-25(15-22)21(28)29-2)26-10-8-17(9-11-26)24-19-12-18(19)16-6-4-3-5-7-16/h3-7,17-19,24H,8-15H2,1-2H3,(H,23,27)/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397611
PNG
(US9994546, Example 110 | [1-(isothiazol-5-ylcarbon...)
Show SMILES O=C(N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1)c1ccns1
Show InChI InChI=1S/C23H27N5OS/c24-10-9-23(15-27(16-23)22(29)21-6-11-25-30-21)28-12-7-18(8-13-28)26-20-14-19(20)17-4-2-1-3-5-17/h1-6,11,18-20,26H,7-9,12-16H2/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397615
PNG
(US9994546, Example 114 | {3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C([C@@H]1CCOC1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H32N4O2/c25-10-9-24(16-27(17-24)23(29)19-8-13-30-15-19)28-11-6-20(7-12-28)26-22-14-21(22)18-4-2-1-3-5-18/h1-5,19-22,26H,6-9,11-17H2/t19-,21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397622
PNG
(N,N-dimethyl-2-[3-(4-{[(1R,2S)-2-phenylcyclopropyl...)
Show SMILES CN(C)C(=O)CC1(CN(C1)C1CCOCC1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C26H40N4O2/c1-28(2)25(31)17-26(18-29(19-26)22-10-14-32-15-11-22)30-12-8-21(9-13-30)27-24-16-23(24)20-6-4-3-5-7-20/h3-7,21-24,27H,8-19H2,1-2H3/t23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397624
PNG
(2-[1-(cyclopropylmethyl)-3-(4-{[(1R,2S)-2-phenylcy...)
Show SMILES CN(C)C(=O)CC1(CN(CC2CC2)C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C25H38N4O/c1-27(2)24(30)15-25(17-28(18-25)16-19-8-9-19)29-12-10-21(11-13-29)26-23-14-22(23)20-6-4-3-5-7-20/h3-7,19,21-23,26H,8-18H2,1-2H3/t22?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397629
PNG
(US9994546, Example 128 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES OC(=O)CC1(CN(Cc2cncs2)C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H30N4O2S/c28-22(29)11-23(14-26(15-23)13-19-12-24-16-30-19)27-8-6-18(7-9-27)25-21-10-20(21)17-4-2-1-3-5-17/h1-5,12,16,18,20-21,25H,6-11,13-15H2,(H,28,29)/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397502
PNG
((1-{4-[(trans-2-Phenylcyclopropyl)amino]piperidin-...)
Show SMILES N#CCC1(CCC1)N1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C20H27N3/c21-12-11-20(9-4-10-20)23-13-7-17(8-14-23)22-19-15-18(19)16-5-2-1-3-6-16/h1-3,5-6,17-19,22H,4,7-11,13-15H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397503
PNG
((1-Methyl-3-{4-[(trans-2-phenylcyclopropyl)amino]p...)
Show SMILES CN1CC(CC#N)(C1)N1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C20H28N4/c1-23-14-20(15-23,9-10-21)24-11-7-17(8-12-24)22-19-13-18(19)16-5-3-2-4-6-16/h2-6,17-19,22H,7-9,11-15H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397510
PNG
((1-(Methylsulfonyl)-3-{4-[(trans-2-phenylcycloprop...)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)N1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C20H28N4O2S/c1-27(25,26)24-14-20(15-24,9-10-21)23-11-7-17(8-12-23)22-19-13-18(19)16-5-3-2-4-6-16/h2-6,17-19,22H,7-9,11-15H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397511
PNG
(2-(3-(Cyanomethyl)-3-{4-[(trans-2-phenylcyclopropy...)
Show SMILES N#CCC1(CN(C1)c1ncccc1C#N)N1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C25H28N6/c26-11-10-25(17-30(18-25)24-20(16-27)7-4-12-28-24)31-13-8-21(9-14-31)29-23-15-22(23)19-5-2-1-3-6-19/h1-7,12,21-23,29H,8-10,13-15,17-18H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397513
PNG
(2-(3-(Cyanomethyl)-3-{4-[(trans-2-phenylcyclopropy...)
Show SMILES N#CCC1(CN(C1)c1ccccc1C#N)N1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C26H29N5/c27-13-12-26(18-30(19-26)25-9-5-4-8-21(25)17-28)31-14-10-22(11-15-31)29-24-16-23(24)20-6-2-1-3-7-20/h1-9,22-24,29H,10-12,14-16,18-19H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397522
PNG
(US9994546, Example 21 | [4-(3-{[(trans-2-Phenylcyc...)
Show SMILES O=S(=O)(N1CCC(CC#N)(CC1)N1CC(CNC2CC2c2ccccc2)C1)c1ccccc1
Show InChI InChI=1S/C26H32N4O2S/c27-14-11-26(12-15-30(16-13-26)33(31,32)23-9-5-2-6-10-23)29-19-21(20-29)18-28-25-17-24(25)22-7-3-1-4-8-22/h1-10,21,24-25,28H,11-13,15-20H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397527
PNG
((3-{[(trans-2-Phenylcyclopropyl)amino]methyl}-1,3&...)
Show SMILES N#CCC1(CNC1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C18H24N4/c19-7-6-18(12-20-13-18)22-10-14(11-22)9-21-17-8-16(17)15-4-2-1-3-5-15/h1-5,14,16-17,20-21H,6,8-13H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397533
PNG
(US9994546, Example 32 | [1-(4-{[(trans-2-Phenylcyc...)
Show SMILES N#CCC1(CCC1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C21H29N3/c22-12-11-21(9-4-10-21)24-13-7-17(8-14-24)16-23-20-15-19(20)18-5-2-1-3-6-18/h1-3,5-6,17,19-20,23H,4,7-11,13-16H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397542
PNG
(Methyl 3-(cyanomethyl)-3-(4-{[(trans-2-phenylcyclo...)
Show SMILES COC(=O)N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C22H30N4O2/c1-28-21(27)25-15-22(16-25,9-10-23)26-11-7-17(8-12-26)14-24-20-13-19(20)18-5-3-2-4-6-18/h2-6,17,19-20,24H,7-9,11-16H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397554
PNG
(US9994546, Example 53 | {1-[4-(4-fluorobenzyl)-4-(...)
Show SMILES OC(=O)CC1(CCC1)N1CCC(CN[C@@H]2CC2c2ccccc2)(Cc2ccc(F)cc2)CC1
Show InChI InChI=1S/C28H35FN2O2/c29-23-9-7-21(8-10-23)18-27(20-30-25-17-24(25)22-5-2-1-3-6-22)13-15-31(16-14-27)28(11-4-12-28)19-26(32)33/h1-3,5-10,24-25,30H,4,11-20H2,(H,32,33)/t24?,25-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397561
PNG
(US9994546, Example 60 | [3-(4-{[(1R,2S)-2-phenylcy...)
Show SMILES N#CCC1(CNC1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C19H26N4/c20-9-8-19(13-21-14-19)23-10-6-16(7-11-23)22-18-12-17(18)15-4-2-1-3-5-15/h1-5,16-18,21-22H,6-8,10-14H2/t17?,18-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397569
PNG
(N,N-dimethyl-2-[1-(4-{[(1R,2S)-2-phenylcyclopropyl...)
Show SMILES CN(C)C(=O)CC1(CCC1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C22H33N3O/c1-24(2)21(26)16-22(11-6-12-22)25-13-9-18(10-14-25)23-20-15-19(20)17-7-4-3-5-8-17/h3-5,7-8,18-20,23H,6,9-16H2,1-2H3/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397581
PNG
(US9994546, Example 80 | [1-[(1-methyl-1H-pyrazol-4...)
Show SMILES Cn1cc(cn1)C(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H30N6O/c1-28-15-19(14-26-28)23(31)29-16-24(17-29,9-10-25)30-11-7-20(8-12-30)27-22-13-21(22)18-5-3-2-4-6-18/h2-6,14-15,20-22,27H,7-9,11-13,16-17H2,1H3/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397589
PNG
(US9994546, Example 88 | [1-[(4-methoxypiperidin-1-...)
Show SMILES COC1CCN(CC1)C(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C26H37N5O2/c1-33-22-9-13-29(14-10-22)25(32)30-18-26(19-30,11-12-27)31-15-7-21(8-16-31)28-24-17-23(24)20-5-3-2-4-6-20/h2-6,21-24,28H,7-11,13-19H2,1H3/t23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397591
PNG
(N,N-dimethyl-2-(1-(methylsulfonyl)-3-(4-(((1R,2S)-...)
Show SMILES CN(C)C(=O)CC1(CN(C1)S(C)(=O)=O)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C22H34N4O3S/c1-24(2)21(27)14-22(15-26(16-22)30(3,28)29)25-11-9-18(10-12-25)23-20-13-19(20)17-7-5-4-6-8-17/h4-8,18-20,23H,9-16H2,1-3H3/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397617
PNG
(US9994546, Example 116 | {3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C([C@@H]1CCCO1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H32N4O2/c25-11-10-24(16-27(17-24)23(29)22-7-4-14-30-22)28-12-8-19(9-13-28)26-21-15-20(21)18-5-2-1-3-6-18/h1-3,5-6,19-22,26H,4,7-10,12-17H2/t20?,21-,22+/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397507
PNG
((1-Acetyl-3-{4-[(trans-2-phenylcyclopropyl)amino]p...)
Show SMILES CC(=O)N1CC(CC#N)(C1)N1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C21H28N4O/c1-16(26)24-14-21(15-24,9-10-22)25-11-7-18(8-12-25)23-20-13-19(20)17-5-3-2-4-6-17/h2-6,18-20,23H,7-9,11-15H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397531
PNG
(1-Phenyl-4-(3-{[(trans-2-phenylcyclopropyl)amino]m...)
Show SMILES N#CC1(CCC(CC1)N1CC(CNC2CC2c2ccccc2)C1)c1ccccc1
Show InChI InChI=1S/C26H31N3/c27-19-26(22-9-5-2-6-10-22)13-11-23(12-14-26)29-17-20(18-29)16-28-25-15-24(25)21-7-3-1-4-8-21/h1-10,20,23-25,28H,11-18H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397535
PNG
(2-[3-(Cyanomethyl)-3-(4-{[(trans-2-phenylcycloprop...)
Show SMILES N#CCC1(CN(C1)c1ncccc1C#N)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C26H30N6/c27-11-10-26(18-31(19-26)25-22(16-28)7-4-12-29-25)32-13-8-20(9-14-32)17-30-24-15-23(24)21-5-2-1-3-6-21/h1-7,12,20,23-24,30H,8-10,13-15,17-19H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397541
PNG
(4-[3-(Cyanomethyl)-3-(4-{[(trans-2-phenylcycloprop...)
Show SMILES N#CCC1(CN(C1)c1ccc(cc1)C#N)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C27H31N5/c28-13-12-27(19-31(20-27)24-8-6-21(17-29)7-9-24)32-14-10-22(11-15-32)18-30-26-16-25(26)23-4-2-1-3-5-23/h1-9,22,25-26,30H,10-12,14-16,18-20H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397549
PNG
(US9994546, Example 48 | [1-(4-Fluorobenzoyl)-3-(4-...)
Show SMILES Fc1ccc(cc1)C(=O)N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C27H31FN4O/c28-23-8-6-22(7-9-23)26(33)31-18-27(19-31,12-13-29)32-14-10-20(11-15-32)17-30-25-16-24(25)21-4-2-1-3-5-21/h1-9,20,24-25,30H,10-12,14-19H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397552
PNG
(N-Methyl-2-(3-(4-((trans-2-phenylcyclopropylamino)...)
Show SMILES CNC(=O)CC1(CNC1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C21H32N4O/c1-22-20(26)12-21(14-23-15-21)25-9-7-16(8-10-25)13-24-19-11-18(19)17-5-3-2-4-6-17/h2-6,16,18-19,23-24H,7-15H2,1H3,(H,22,26)
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397568
PNG
(US9994546, Example 67 | [1-ethyl-3-(4-{[(1R,2S)-2-...)
Show SMILES CCN1CC(CC(O)=O)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C21H31N3O2/c1-2-23-14-21(15-23,13-20(25)26)24-10-8-17(9-11-24)22-19-12-18(19)16-6-4-3-5-7-16/h3-7,17-19,22H,2,8-15H2,1H3,(H,25,26)/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397573
PNG
(US9994546, Example 72 | [1-(trans-4-hydroxycyclohe...)
Show SMILES O[C@H]1CC[C@@H](CC1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C25H36N4O/c26-13-12-25(17-28(18-25)21-6-8-22(30)9-7-21)29-14-10-20(11-15-29)27-24-16-23(24)19-4-2-1-3-5-19/h1-5,20-24,27,30H,6-12,14-18H2/t21-,22-,23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397575
PNG
(US9994546, Example 74 | [1-(2-hydroxyethyl)-3-(4-{...)
Show SMILES OCCN1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C21H30N4O/c22-9-8-21(15-24(16-21)12-13-26)25-10-6-18(7-11-25)23-20-14-19(20)17-4-2-1-3-5-17/h1-5,18-20,23,26H,6-8,10-16H2/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397578
PNG
(2-(3-(cyanomethyl)-3-(4-(((1R,2S)-2-phenylcyclopro...)
Show SMILES CN(C)C(=O)CN1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H33N5O/c1-26(2)22(29)15-27-16-23(17-27,10-11-24)28-12-8-19(9-13-28)25-21-14-20(21)18-6-4-3-5-7-18/h3-7,19-21,25H,8-10,12-17H2,1-2H3/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397582
PNG
(US9994546, Example 81 | [1-[(1-methyl-1H-pyrazol-5...)
Show SMILES Cn1nccc1C(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H30N6O/c1-28-22(7-12-26-28)23(31)29-16-24(17-29,10-11-25)30-13-8-19(9-14-30)27-21-15-20(21)18-5-3-2-4-6-18/h2-7,12,19-21,27H,8-10,13-17H2,1H3/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397599
PNG
(US9994546, Example 98 | [1-(1-methyl-1H-pyrazol-4-...)
Show SMILES Cn1cc(cn1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H30N6/c1-27-15-20(14-25-27)28-16-23(17-28,9-10-24)29-11-7-19(8-12-29)26-22-13-21(22)18-5-3-2-4-6-18/h2-6,14-15,19,21-22,26H,7-9,11-13,16-17H2,1H3/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397613
PNG
(US9994546, Example 112 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C(N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1)c1cn[nH]c1
Show InChI InChI=1/C23H28N6O/c24-9-8-23(15-28(16-23)22(30)18-13-25-26-14-18)29-10-6-19(7-11-29)27-21-12-20(21)17-4-2-1-3-5-17/h1-5,13-14,19-21,27H,6-8,10-12,15-16H2,(H,25,26)/t20?,21-/s2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397618
PNG
(US9994546, Example 117 | {3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C([C@H]1CCCO1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H32N4O2/c25-11-10-24(16-27(17-24)23(29)22-7-4-14-30-22)28-12-8-19(9-13-28)26-21-15-20(21)18-5-2-1-3-6-18/h1-3,5-6,19-22,26H,4,7-10,12-17H2/t20?,21-,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397623
PNG
(N-methyl-2-[3-(4-{[(1R,2S)-2-phenylcyclopropyl]ami...)
Show SMILES CNC(=O)CC1(CN(C1)C1CCOCC1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C25H38N4O2/c1-26-24(30)16-25(17-28(18-25)21-9-13-31-14-10-21)29-11-7-20(8-12-29)27-23-15-22(23)19-5-3-2-4-6-19/h2-6,20-23,27H,7-18H2,1H3,(H,26,30)/t22?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397504
PNG
((3-{4-[(trans-2-Phenylcyclopropyl)amino]piperidin-...)
Show SMILES N#CCC1(CNC1)N1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C19H26N4/c20-9-8-19(13-21-14-19)23-10-6-16(7-11-23)22-18-12-17(18)15-4-2-1-3-5-15/h1-5,16-18,21-22H,6-8,10-14H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397509
PNG
(Methyl 3-(cyanomethyl)-3-{4-[(trans-2-phenylcyclop...)
Show SMILES COC(=O)N1CC(CC#N)(C1)N1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C21H28N4O2/c1-27-20(26)24-14-21(15-24,9-10-22)25-11-7-17(8-12-25)23-19-13-18(19)16-5-3-2-4-6-16/h2-6,17-19,23H,7-9,11-15H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397515
PNG
(US9994546, Example 14 | [1-(3-{[(trans-2-Phenylcyc...)
Show SMILES N#CCC1(CCC1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C19H25N3/c20-10-9-19(7-4-8-19)22-13-15(14-22)12-21-18-11-17(18)16-5-2-1-3-6-16/h1-3,5-6,15,17-18,21H,4,7-9,11-14H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397516
PNG
((1′-(Ethylsulfonyl)-3-{[(trans-2-phenylcyclo...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C20H28N4O2S/c1-2-27(25,26)24-14-20(15-24,8-9-21)23-12-16(13-23)11-22-19-10-18(19)17-6-4-3-5-7-17/h3-7,16,18-19,22H,2,8,10-15H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397530
PNG
(Trans-2-phenyl-N-{[1-(1-phenylpiperidin-4-yl)azeti...)
Show SMILES C(NC1CC1c1ccccc1)C1CN(C1)C1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C24H31N3/c1-3-7-20(8-4-1)23-15-24(23)25-16-19-17-27(18-19)22-11-13-26(14-12-22)21-9-5-2-6-10-21/h1-10,19,22-25H,11-18H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397547
PNG
(US9994546, Example 46 | [1-(2-Fluorobenzoyl)-3-(4-...)
Show SMILES Fc1ccccc1C(=O)N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C27H31FN4O/c28-24-9-5-4-8-22(24)26(33)31-18-27(19-31,12-13-29)32-14-10-20(11-15-32)17-30-25-16-23(25)21-6-2-1-3-7-21/h1-9,20,23,25,30H,10-12,14-19H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397556
PNG
(US9994546, Example 55 | {1-[4-methyl-4-({[(1R,2S)-...)
Show SMILES CC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C1(CC(O)=O)CCC1
Show InChI InChI=1S/C22H32N2O2/c1-21(16-23-19-14-18(19)17-6-3-2-4-7-17)10-12-24(13-11-21)22(8-5-9-22)15-20(25)26/h2-4,6-7,18-19,23H,5,8-16H2,1H3,(H,25,26)/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397562
PNG
(US9994546, Example 61 | [3-(4-{[(1S,2R)-2-phenylcy...)
Show SMILES N#CCC1(CNC1)N1CCC(CC1)N[C@H]1C[C@@H]1c1ccccc1
Show InChI InChI=1S/C19H26N4/c20-9-8-19(13-21-14-19)23-10-6-16(7-11-23)22-18-12-17(18)15-4-2-1-3-5-15/h1-5,16-18,21-22H,6-8,10-14H2/t17-,18+/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397565
PNG
(3-(cyanomethyl)-N-methyl-3-(4-{[(1R,2S)-2-phenylcy...)
Show SMILES CNS(=O)(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C20H29N5O2S/c1-22-28(26,27)25-14-20(15-25,9-10-21)24-11-7-17(8-12-24)23-19-13-18(19)16-5-3-2-4-6-16/h2-6,17-19,22-23H,7-9,11-15H2,1H3/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397567
PNG
(US9994546, Example 66 | [1-methyl-3-(4-{[(1R,2S)-2...)
Show SMILES CN1CC(CC(O)=O)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C20H29N3O2/c1-22-13-20(14-22,12-19(24)25)23-9-7-16(8-10-23)21-18-11-17(18)15-5-3-2-4-6-15/h2-6,16-18,21H,7-14H2,1H3,(H,24,25)/t17?,18-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397570
PNG
(N-methyl-2-[1-(4-{[(1R,2S)-2-phenylcyclopropyl]ami...)
Show SMILES CNC(=O)CC1(CCC1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C21H31N3O/c1-22-20(25)15-21(10-5-11-21)24-12-8-17(9-13-24)23-19-14-18(19)16-6-3-2-4-7-16/h2-4,6-7,17-19,23H,5,8-15H2,1H3,(H,22,25)/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397577
PNG
(US9994546, Example 76 | [3-(4-{[(1R,2S)-2-phenylcy...)
Show SMILES N#CCC1(CN(C1)C1CCOC1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H32N4O/c24-10-9-23(16-26(17-23)20-8-13-28-15-20)27-11-6-19(7-12-27)25-22-14-21(22)18-4-2-1-3-5-18/h1-5,19-22,25H,6-9,11-17H2/t20?,21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397595
PNG
(US9994546, Example 94 | methyl 3-[2-(dimethylamino...)
Show SMILES COC(=O)N1CC(CC(=O)N(C)C)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H34N4O3/c1-25(2)21(28)14-23(15-26(16-23)22(29)30-3)27-11-9-18(10-12-27)24-20-13-19(20)17-7-5-4-6-8-17/h4-8,18-20,24H,9-16H2,1-3H3/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397601
PNG
(US9994546, Example 100 | [1-[(1-methyl-1H-pyrazol-...)
Show SMILES Cn1cc(cn1)S(=O)(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H30N6O2S/c1-27-15-20(14-25-27)32(30,31)29-16-23(17-29,9-10-24)28-11-7-19(8-12-28)26-22-13-21(22)18-5-3-2-4-6-18/h2-6,14-15,19,21-22,26H,7-9,11-13,16-17H2,1H3/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397606
PNG
(US9994546, Example 105 | {1-[4-({[(1R,2S)-2-phenyl...)
Show SMILES OC(=O)CC1(CCC1)N1CCC(CN[C@@H]2CC2c2ccccc2)CC1
Show InChI InChI=1S/C21H30N2O2/c24-20(25)14-21(9-4-10-21)23-11-7-16(8-12-23)15-22-19-13-18(19)17-5-2-1-3-6-17/h1-3,5-6,16,18-19,22H,4,7-15H2,(H,24,25)/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397610
PNG
(US9994546, Example 109 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C(N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1)c1cncs1
Show InChI InChI=1S/C23H27N5OS/c24-9-8-23(14-27(15-23)22(29)21-13-25-16-30-21)28-10-6-18(7-11-28)26-20-12-19(20)17-4-2-1-3-5-17/h1-5,13,16,18-20,26H,6-8,10-12,14-15H2/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397612
PNG
(US9994546, Example 111 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C(N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1)c1cnccn1
Show InChI InChI=1S/C24H28N6O/c25-9-8-24(16-29(17-24)23(31)22-15-26-10-11-27-22)30-12-6-19(7-13-30)28-21-14-20(21)18-4-2-1-3-5-18/h1-5,10-11,15,19-21,28H,6-8,12-14,16-17H2/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397524
PNG
(4-(Cyanomethyl)-N,N-dimethyl-4-(3-{[(trans-2-pheny...)
Show SMILES CN(C)C(=O)N1CCC(CC#N)(CC1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C23H33N5O/c1-26(2)22(29)27-12-9-23(8-11-24,10-13-27)28-16-18(17-28)15-25-21-14-20(21)19-6-4-3-5-7-19/h3-7,18,20-21,25H,8-10,12-17H2,1-2H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397528
PNG
(4-(3′-(Cyanomethyl)-3-{[(trans-2-phenylcyclo...)
Show SMILES C[C@H](NC(=O)c1cc(F)c(cc1F)N1CC(CC#N)(C1)N1CC(CNC2CC2c2ccccc2)C1)C(F)(F)F
Show InChI InChI=1S/C28H30F5N5O/c1-17(28(31,32)33)36-26(39)21-9-23(30)25(11-22(21)29)37-15-27(16-37,7-8-34)38-13-18(14-38)12-35-24-10-20(24)19-5-3-2-4-6-19/h2-6,9,11,17-18,20,24,35H,7,10,12-16H2,1H3,(H,36,39)/t17-,20?,24?/m0/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397545
PNG
(US9994546, Example 44 | [1-(3,5-Difluorobenzoyl)-3...)
Show SMILES Fc1cc(F)cc(c1)C(=O)N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C27H30F2N4O/c28-22-12-21(13-23(29)14-22)26(34)32-17-27(18-32,8-9-30)33-10-6-19(7-11-33)16-31-25-15-24(25)20-4-2-1-3-5-20/h1-5,12-14,19,24-25,31H,6-8,10-11,15-18H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397550
PNG
(US9994546, Example 49 | [1-Methyl-3-(4-{[(trans-2-...)
Show SMILES CN1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C21H30N4/c1-24-15-21(16-24,9-10-22)25-11-7-17(8-12-25)14-23-20-13-19(20)18-5-3-2-4-6-18/h2-6,17,19-20,23H,7-9,11-16H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397555
PNG
(US9994546, Example 54 | {1-[4-(methoxymethyl)-4-({...)
Show SMILES COCC1(CN[C@@H]2CC2c2ccccc2)CCN(CC1)C1(CC(O)=O)CCC1
Show InChI InChI=1S/C23H34N2O3/c1-28-17-22(16-24-20-14-19(20)18-6-3-2-4-7-18)10-12-25(13-11-22)23(8-5-9-23)15-21(26)27/h2-4,6-7,19-20,24H,5,8-17H2,1H3,(H,26,27)/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397560
PNG
(US9994546, Example 59 | [1-methyl-3-(4-{[(1R,2S)-2...)
Show SMILES CN1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C20H28N4/c1-23-14-20(15-23,9-10-21)24-11-7-17(8-12-24)22-19-13-18(19)16-5-3-2-4-6-16/h2-6,17-19,22H,7-9,11-15H2,1H3/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397590
PNG
(US9994546, Example 89 | [1-[(3-hydroxyazetidin-1-y...)
Show SMILES OC1CN(C1)C(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H31N5O2/c24-9-8-23(15-27(16-23)22(30)26-13-19(29)14-26)28-10-6-18(7-11-28)25-21-12-20(21)17-4-2-1-3-5-17/h1-5,18-21,25,29H,6-8,10-16H2/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397592
PNG
(N-methyl-2-[1-(methylsulfonyl)-3-(4-{[(1R,2S)-2-ph...)
Show SMILES CNC(=O)CC1(CN(C1)S(C)(=O)=O)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C21H32N4O3S/c1-22-20(26)13-21(14-25(15-21)29(2,27)28)24-10-8-17(9-11-24)23-19-12-18(19)16-6-4-3-5-7-16/h3-7,17-19,23H,8-15H2,1-2H3,(H,22,26)/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397597
PNG
(3-[2-(dimethylamino)-2-oxoethyl]-N,N-dimethyl-3-(4...)
Show SMILES CN(C)C(=O)CC1(CN(C1)C(=O)N(C)C)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H37N5O2/c1-26(2)22(30)15-24(16-28(17-24)23(31)27(3)4)29-12-10-19(11-13-29)25-21-14-20(21)18-8-6-5-7-9-18/h5-9,19-21,25H,10-17H2,1-4H3/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397600
PNG
(US9994546, Example 99 | tetrahydrofuran-3-yl 3-(cy...)
Show SMILES O=C(OC1CCOC1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H32N4O3/c25-10-9-24(16-27(17-24)23(29)31-20-8-13-30-15-20)28-11-6-19(7-12-28)26-22-14-21(22)18-4-2-1-3-5-18/h1-5,19-22,26H,6-9,11-17H2/t20?,21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397602
PNG
(US9994546, Example 101 | [3-(4-{[(1R,2S)-2-(4-fluo...)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccc(F)cc1
Show InChI InChI=1S/C20H27FN4O2S/c1-28(26,27)25-13-20(14-25,8-9-22)24-10-6-17(7-11-24)23-19-12-18(19)15-2-4-16(21)5-3-15/h2-5,17-19,23H,6-8,10-14H2,1H3/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397603
PNG
(3-(cyanomethyl)-3-(4-{[(1R,2S)-2-(4-fluorophenyl)c...)
Show SMILES NS(=O)(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccc(F)cc1
Show InChI InChI=1S/C19H26FN5O2S/c20-15-3-1-14(2-4-15)17-11-18(17)23-16-5-9-24(10-6-16)19(7-8-21)12-25(13-19)28(22,26)27/h1-4,16-18,23H,5-7,9-13H2,(H2,22,26,27)/t17?,18-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397609
PNG
(US9994546, Example 108 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C(C1CCOC1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H32N4O2/c25-10-9-24(16-27(17-24)23(29)19-8-13-30-15-19)28-11-6-20(7-12-28)26-22-14-21(22)18-4-2-1-3-5-18/h1-5,19-22,26H,6-9,11-17H2/t19?,21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397619
PNG
(US9994546, Example 118 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C(Cc1ccccn1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C26H31N5O/c27-12-11-26(18-30(19-26)25(32)16-22-8-4-5-13-28-22)31-14-9-21(10-15-31)29-24-17-23(24)20-6-2-1-3-7-20/h1-8,13,21,23-24,29H,9-11,14-19H2/t23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397620
PNG
(US9994546, Example 119 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C(N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1)c1cscn1
Show InChI InChI=1S/C23H27N5OS/c24-9-8-23(14-27(15-23)22(29)21-13-30-16-25-21)28-10-6-18(7-11-28)26-20-12-19(20)17-4-2-1-3-5-17/h1-5,13,16,18-20,26H,6-8,10-12,14-15H2/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397505
PNG
((1-Benzyl-3-{4-[(trans-2-phenylcyclopropyl)amino]p...)
Show SMILES N#CCC1(CN(Cc2ccccc2)C1)N1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C26H32N4/c27-14-13-26(19-29(20-26)18-21-7-3-1-4-8-21)30-15-11-23(12-16-30)28-25-17-24(25)22-9-5-2-6-10-22/h1-10,23-25,28H,11-13,15-20H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397508
PNG
((1-Benzoyl-3-{4-[(trans-2-phenylcyclopropyl)amino]...)
Show SMILES O=C(N1CC(CC#N)(C1)N1CCC(CC1)NC1CC1c1ccccc1)c1ccccc1
Show InChI InChI=1S/C26H30N4O/c27-14-13-26(18-29(19-26)25(31)21-9-5-2-6-10-21)30-15-11-22(12-16-30)28-24-17-23(24)20-7-3-1-4-8-20/h1-10,22-24,28H,11-13,15-19H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397519
PNG
(US9994546, Example 18 | [1-Acetyl-4-(3-{[(trans-2-...)
Show SMILES CC(=O)N1CCC(CC#N)(CC1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C22H30N4O/c1-17(27)25-11-8-22(7-10-23,9-12-25)26-15-18(16-26)14-24-21-13-20(21)19-5-3-2-4-6-19/h2-6,18,20-21,24H,7-9,11-16H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397520
PNG
(US9994546, Example 19 | [1-(4-Fluorobenzoyl)-4-(3-...)
Show SMILES Fc1ccc(cc1)C(=O)N1CCC(CC#N)(CC1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C27H31FN4O/c28-23-8-6-22(7-9-23)26(33)31-14-11-27(10-13-29,12-15-31)32-18-20(19-32)17-30-25-16-24(25)21-4-2-1-3-5-21/h1-9,20,24-25,30H,10-12,14-19H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397526
PNG
(4-(Cyanomethyl)-N-(4-fluorophenyl)-4-(3-{[(trans-2...)
Show SMILES Fc1ccc(NC(=O)N2CCC(CC#N)(CC2)N2CC(CNC3CC3c3ccccc3)C2)cc1
Show InChI InChI=1S/C27H32FN5O/c28-22-6-8-23(9-7-22)31-26(34)32-14-11-27(10-13-29,12-15-32)33-18-20(19-33)17-30-25-16-24(25)21-4-2-1-3-5-21/h1-9,20,24-25,30H,10-12,14-19H2,(H,31,34)
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397529
PNG
(N-{[1-(1-Methylpiperidin-4-yl)azetidin-3-yl]methyl...)
Show SMILES CN1CCC(CC1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C19H29N3/c1-21-9-7-17(8-10-21)22-13-15(14-22)12-20-19-11-18(19)16-5-3-2-4-6-16/h2-6,15,17-20H,7-14H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397534
PNG
(US9994546, Example 33 | [3-(4-{[(trans-2-Phenylcyc...)
Show SMILES N#CCC1(CNC1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C20H28N4/c21-9-8-20(14-22-15-20)24-10-6-16(7-11-24)13-23-19-12-18(19)17-4-2-1-3-5-17/h1-5,16,18-19,22-23H,6-8,10-15H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397538
PNG
(US9994546, Example 37 | {3-(4-{[(trans-2-Phenylcyc...)
Show SMILES FC(F)(F)c1ccc(nc1)N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C26H30F3N5/c27-26(28,29)21-6-7-24(32-16-21)33-17-25(18-33,10-11-30)34-12-8-19(9-13-34)15-31-23-14-22(23)20-4-2-1-3-5-20/h1-7,16,19,22-23,31H,8-10,12-15,17-18H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397540
PNG
(2-[3-(Cyanomethyl)-3-(4-{[(trans-2-phenylcycloprop...)
Show SMILES N#CCC1(CN(C1)c1ccccc1C#N)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C27H31N5/c28-13-12-27(19-31(20-27)26-9-5-4-8-23(26)17-29)32-14-10-21(11-15-32)18-30-25-16-24(25)22-6-2-1-3-7-22/h1-9,21,24-25,30H,10-12,14-16,18-20H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397551
PNG
(US9994546, Example 50 | [3-(4-{[(trans-2-Phenylcyc...)
Show SMILES OC(=O)CC1(CNC1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C20H29N3O2/c24-19(25)11-20(13-21-14-20)23-8-6-15(7-9-23)12-22-18-10-17(18)16-4-2-1-3-5-16/h1-5,15,17-18,21-22H,6-14H2,(H,24,25)
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397571
PNG
(2-[1-(ethylsulfonyl)-3-(4-{[(1R,2S)-2-phenylcyclop...)
Show SMILES CCS(=O)(=O)N1CC(CC(=O)N(C)C)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H36N4O3S/c1-4-31(29,30)27-16-23(17-27,15-22(28)25(2)3)26-12-10-19(11-13-26)24-21-14-20(21)18-8-6-5-7-9-18/h5-9,19-21,24H,4,10-17H2,1-3H3/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397576
PNG
(US9994546, Example 75 | [3-(4-{[(1R,2S)-2-phenylcy...)
Show SMILES N#CCC1(CN(C1)C1CCOCC1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H34N4O/c25-11-10-24(17-27(18-24)21-8-14-29-15-9-21)28-12-6-20(7-13-28)26-23-16-22(23)19-4-2-1-3-5-19/h1-5,20-23,26H,6-10,12-18H2/t22?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397579
PNG
(2-[3-(cyanomethyl)-3-(4-{[(1R,2S)-2-phenylcyclopro...)
Show SMILES CNC(=O)CN1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C22H31N5O/c1-24-21(28)14-26-15-22(16-26,9-10-23)27-11-7-18(8-12-27)25-20-13-19(20)17-5-3-2-4-6-17/h2-6,18-20,25H,7-9,11-16H2,1H3,(H,24,28)/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397583
PNG
(US9994546, Example 82 | [1-[(trans-4-hydroxycycloh...)
Show SMILES O[C@H]1CC[C@@H](CC1)C(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C26H36N4O2/c27-13-12-26(17-29(18-26)25(32)20-6-8-22(31)9-7-20)30-14-10-21(11-15-30)28-24-16-23(24)19-4-2-1-3-5-19/h1-5,20-24,28,31H,6-12,14-18H2/t20-,22-,23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397587
PNG
(US9994546, Example 86 | [1-(morpholin-4-ylcarbonyl...)
Show SMILES O=C(N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1)N1CCOCC1
Show InChI InChI=1S/C24H33N5O2/c25-9-8-24(17-28(18-24)23(30)27-12-14-31-15-13-27)29-10-6-20(7-11-29)26-22-16-21(22)19-4-2-1-3-5-19/h1-5,20-22,26H,6-8,10-18H2/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397588
PNG
(US9994546, Example 87 | [1-[(4-hydroxypiperidin-1-...)
Show SMILES OC1CCN(CC1)C(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C25H35N5O2/c26-11-10-25(17-29(18-25)24(32)28-12-8-21(31)9-13-28)30-14-6-20(7-15-30)27-23-16-22(23)19-4-2-1-3-5-19/h1-5,20-23,27,31H,6-10,12-18H2/t22?,23-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397593
PNG
(2-[1-(ethylsulfonyl)-3-(4-{[(1R,2S)-2-phenylcyclop...)
Show SMILES CCS(=O)(=O)N1CC(CCO)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C21H33N3O3S/c1-2-28(26,27)24-15-21(16-24,10-13-25)23-11-8-18(9-12-23)22-20-14-19(20)17-6-4-3-5-7-17/h3-7,18-20,22,25H,2,8-16H2,1H3/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397604
PNG
(US9994546, Example 103 | US9994546, Example 104 | ...)
Show SMILES OC1CCC(CC1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccc(F)cc1
Show InChI InChI=1S/C25H35FN4O/c26-19-3-1-18(2-4-19)23-15-24(23)28-20-9-13-30(14-10-20)25(11-12-27)16-29(17-25)21-5-7-22(31)8-6-21/h1-4,20-24,28,31H,5-11,13-17H2/t21?,22?,23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397517
PNG
(US9994546, Example 16 | [4-(3-{[(trans-2-Phenylcyc...)
Show SMILES N#CCC1(CCNCC1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C20H28N4/c21-9-6-20(7-10-22-11-8-20)24-14-16(15-24)13-23-19-12-18(19)17-4-2-1-3-5-17/h1-5,16,18-19,22-23H,6-8,10-15H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397521
PNG
(US9994546, Example 20 | [1-(Methylsulfonyl)-4-(3-{...)
Show SMILES CS(=O)(=O)N1CCC(CC#N)(CC1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C21H30N4O2S/c1-28(26,27)25-11-8-21(7-10-22,9-12-25)24-15-17(16-24)14-23-20-13-19(20)18-5-3-2-4-6-18/h2-6,17,19-20,23H,7-9,11-16H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397523
PNG
(Ethyl 4-(cyanomethyl)-4-(3-{[(trans-2-phenylcyclop...)
Show SMILES CCOC(=O)N1CCC(CC#N)(CC1)N1CC(CNC2CC2c2ccccc2)C1
Show InChI InChI=1S/C23H32N4O2/c1-2-29-22(28)26-12-9-23(8-11-24,10-13-26)27-16-18(17-27)15-25-21-14-20(21)19-6-4-3-5-7-19/h3-7,18,20-21,25H,2,8-10,12-17H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397543
PNG
(3-(Cyanomethyl)-N-(2,4-difluorophenyl)-3-(4-{[(tra...)
Show SMILES Fc1ccc(NC(=O)N2CC(CC#N)(C2)N2CCC(CNC3CC3c3ccccc3)CC2)c(F)c1
Show InChI InChI=1S/C27H31F2N5O/c28-21-6-7-24(23(29)14-21)32-26(35)33-17-27(18-33,10-11-30)34-12-8-19(9-13-34)16-31-25-15-22(25)20-4-2-1-3-5-20/h1-7,14,19,22,25,31H,8-10,12-13,15-18H2,(H,32,35)
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397546
PNG
(US9994546, Example 45 | [1-Benzoyl-3-(4-{[(trans-2...)
Show SMILES O=C(N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1)c1ccccc1
Show InChI InChI=1S/C27H32N4O/c28-14-13-27(19-30(20-27)26(32)23-9-5-2-6-10-23)31-15-11-21(12-16-31)18-29-25-17-24(25)22-7-3-1-4-8-22/h1-10,21,24-25,29H,11-13,15-20H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397557
PNG
(N,N-dimethyl-2-{1-[4-methyl-4-({[(1R,2S)-2-phenylc...)
Show SMILES CN(C)C(=O)CC1(CCC1)N1CCC(C)(CN[C@@H]2CC2c2ccccc2)CC1
Show InChI InChI=1S/C24H37N3O/c1-23(18-25-21-16-20(21)19-8-5-4-6-9-19)12-14-27(15-13-23)24(10-7-11-24)17-22(28)26(2)3/h4-6,8-9,20-21,25H,7,10-18H2,1-3H3/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397558
PNG
(N-methyl-2-{1-[4-methyl-4-({[(1R,2S)-2-phenylcyclo...)
Show SMILES CNC(=O)CC1(CCC1)N1CCC(C)(CN[C@@H]2CC2c2ccccc2)CC1
Show InChI InChI=1S/C23H35N3O/c1-22(17-25-20-15-19(20)18-7-4-3-5-8-18)11-13-26(14-12-22)23(9-6-10-23)16-21(27)24-2/h3-5,7-8,19-20,25H,6,9-17H2,1-2H3,(H,24,27)/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397564
PNG
(3-(cyanomethyl)-N,N-dimethyl-3-(4-{[(1R,2S)-2-phen...)
Show SMILES CN(C)S(=O)(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C21H31N5O2S/c1-24(2)29(27,28)26-15-21(16-26,10-11-22)25-12-8-18(9-13-25)23-20-14-19(20)17-6-4-3-5-7-17/h3-7,18-20,23H,8-10,12-16H2,1-2H3/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397566
PNG
(3-(cyanomethyl)-3-(4-{[(1R,2S)-2-phenylcyclopropyl...)
Show SMILES NS(=O)(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C19H27N5O2S/c20-9-8-19(13-24(14-19)27(21,25)26)23-10-6-16(7-11-23)22-18-12-17(18)15-4-2-1-3-5-15/h1-5,16-18,22H,6-8,10-14H2,(H2,21,25,26)/t17?,18-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397572
PNG
(2-[1-(ethylsulfonyl)-3-(4-{[(1R,2S)-2-phenylcyclop...)
Show SMILES CCS(=O)(=O)N1CC(CC(=O)NC)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C22H34N4O3S/c1-3-30(28,29)26-15-22(16-26,14-21(27)23-2)25-11-9-18(10-12-25)24-20-13-19(20)17-7-5-4-6-8-17/h4-8,18-20,24H,3,9-16H2,1-2H3,(H,23,27)/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397586
PNG
(US9994546, Example 85 | [1-[(1-hydroxycyclopentyl)...)
Show SMILES OC1(CCCC1)C(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C25H34N4O2/c26-13-12-24(17-28(18-24)23(30)25(31)10-4-5-11-25)29-14-8-20(9-15-29)27-22-16-21(22)19-6-2-1-3-7-19/h1-3,6-7,20-22,27,31H,4-5,8-12,14-18H2/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397598
PNG
(N,N-dimethyl-3-[2-(methylamino)-2-oxoethyl]-3-(4-{...)
Show SMILES CNC(=O)CC1(CN(C1)C(=O)N(C)C)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H35N5O2/c1-24-21(29)14-23(15-27(16-23)22(30)26(2)3)28-11-9-18(10-12-28)25-20-13-19(20)17-7-5-4-6-8-17/h4-8,18-20,25H,9-16H2,1-3H3,(H,24,29)/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397607
PNG
(US9994546, Example 106 | [1-(3-hydroxycyclobutyl)-...)
Show SMILES OC1CC(C1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H32N4O/c24-9-8-23(15-26(16-23)19-12-20(28)13-19)27-10-6-18(7-11-27)25-22-14-21(22)17-4-2-1-3-5-17/h1-5,18-22,25,28H,6-8,10-16H2/t19?,20?,21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397616
PNG
(US9994546, Example 115 | {3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C([C@H]1CCOC1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H32N4O2/c25-10-9-24(16-27(17-24)23(29)19-8-13-30-15-19)28-11-6-20(7-12-28)26-22-14-21(22)18-4-2-1-3-5-18/h1-5,19-22,26H,6-9,11-17H2/t19-,21?,22+/m0/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397625
PNG
(2-[1-(cyclopropylmethyl)-3-(4-{[(1R,2S)-2-phenylcy...)
Show SMILES CNC(=O)CC1(CN(CC2CC2)C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H36N4O/c1-25-23(29)14-24(16-27(17-24)15-18-7-8-18)28-11-9-20(10-12-28)26-22-13-21(22)19-5-3-2-4-6-19/h2-6,18,20-22,26H,7-17H2,1H3,(H,25,29)/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397626
PNG
(US9994546, Example 125 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES OC(=O)CC1(CN(Cc2ncccn2)C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H31N5O2/c30-23(31)14-24(16-28(17-24)15-22-25-9-4-10-26-22)29-11-7-19(8-12-29)27-21-13-20(21)18-5-2-1-3-6-18/h1-6,9-10,19-21,27H,7-8,11-17H2,(H,30,31)/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397627
PNG
(US9994546, Example 126 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES OC(=O)CC1(CN(Cc2cncnc2)C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H31N5O2/c30-23(31)11-24(15-28(16-24)14-18-12-25-17-26-13-18)29-8-6-20(7-9-29)27-22-10-21(22)19-4-2-1-3-5-19/h1-5,12-13,17,20-22,27H,6-11,14-16H2,(H,30,31)/t21?,22-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397630
PNG
(US9994546, Example 129 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES OC(=O)CC1(CN(Cc2nccs2)C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H30N4O2S/c28-22(29)13-23(15-26(16-23)14-21-24-8-11-30-21)27-9-6-18(7-10-27)25-20-12-19(20)17-4-2-1-3-5-17/h1-5,8,11,18-20,25H,6-7,9-10,12-16H2,(H,28,29)/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397631
PNG
(US9994546, Example 130 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES OC(=O)CC1(CN(CCC(F)(F)F)C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C22H30F3N3O2/c23-22(24,25)8-11-27-14-21(15-27,13-20(29)30)28-9-6-17(7-10-28)26-19-12-18(19)16-4-2-1-3-5-16/h1-5,17-19,26H,6-15H2,(H,29,30)/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397506
PNG
(3-(3-(Cyanomethyl)-3-{4-[(trans-2-phenylcyclopropy...)
Show SMILES OC(=O)CCN1CC(CC#N)(C1)N1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C22H30N4O2/c23-10-9-22(15-25(16-22)11-8-21(27)28)26-12-6-18(7-13-26)24-20-14-19(20)17-4-2-1-3-5-17/h1-5,18-20,24H,6-9,11-16H2,(H,27,28)
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397514
PNG
(4-(3-(Cyanomethyl)-3-{4-[(trans-2-phenylcyclopropy...)
Show SMILES N#CCC1(CN(C1)c1ccc(cc1)C#N)N1CCC(CC1)NC1CC1c1ccccc1
Show InChI InChI=1S/C26H29N5/c27-13-12-26(18-30(19-26)23-8-6-20(17-28)7-9-23)31-14-10-22(11-15-31)29-25-16-24(25)21-4-2-1-3-5-21/h1-9,22,24-25,29H,10-12,14-16,18-19H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397539
PNG
(2-Chloro-6-[3-(cyanomethyl)-3-(4-{[(trans-2-phenyl...)
Show SMILES Clc1cccc(N2CC(CC#N)(C2)N2CCC(CNC3CC3c3ccccc3)CC2)c1C#N
Show InChI InChI=1S/C27H30ClN5/c28-24-7-4-8-26(23(24)16-30)32-18-27(19-32,11-12-29)33-13-9-20(10-14-33)17-31-25-15-22(25)21-5-2-1-3-6-21/h1-8,20,22,25,31H,9-11,13-15,17-19H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397548
PNG
(US9994546, Example 47 | [1-(3-Fluorobenzoyl)-3-(4-...)
Show SMILES Fc1cccc(c1)C(=O)N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C27H31FN4O/c28-23-8-4-7-22(15-23)26(33)31-18-27(19-31,11-12-29)32-13-9-20(10-14-32)17-30-25-16-24(25)21-5-2-1-3-6-21/h1-8,15,20,24-25,30H,9-11,13-14,16-19H2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397553
PNG
(N,N-Dimethyl-2-(3-(4-((trans-2-phenylcyclopropylam...)
Show SMILES CN(C)C(=O)CC1(CNC1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C22H34N4O/c1-25(2)21(27)13-22(15-23-16-22)26-10-8-17(9-11-26)14-24-20-12-19(20)18-6-4-3-5-7-18/h3-7,17,19-20,23-24H,8-16H2,1-2H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397559
PNG
(US9994546, Example 58 | [1-(methylsulfonyl)-3-(4-{...)
Show SMILES CS(=O)(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C20H28N4O2S/c1-27(25,26)24-14-20(15-24,9-10-21)23-11-7-17(8-12-23)22-19-13-18(19)16-5-3-2-4-6-16/h2-6,17-19,22H,7-9,11-15H2,1H3/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397563
PNG
(US9994546, Example 62 | [1-(ethylsulfonyl)-3-(4-{[...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C21H30N4O2S/c1-2-28(26,27)25-15-21(16-25,10-11-22)24-12-8-18(9-13-24)23-20-14-19(20)17-6-4-3-5-7-17/h3-7,18-20,23H,2,8-10,12-16H2,1H3/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397574
PNG
(US9994546, Example 73 | [1-(cis-4-hydroxycyclohexy...)
Show SMILES O[C@H]1CC[C@H](CC1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C25H36N4O/c26-13-12-25(17-28(18-25)21-6-8-22(30)9-7-21)29-14-10-20(11-15-29)27-24-16-23(24)19-4-2-1-3-5-19/h1-5,20-24,27,30H,6-12,14-18H2/t21-,22+,23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397580
PNG
(2-[3-(cyanomethyl)-3-(4-{[(1R,2S)-2-phenylcyclopro...)
Show SMILES NC(=O)CN1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C21H29N5O/c22-9-8-21(14-25(15-21)13-20(23)27)26-10-6-17(7-11-26)24-19-12-18(19)16-4-2-1-3-5-16/h1-5,17-19,24H,6-8,10-15H2,(H2,23,27)/t18?,19-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397585
PNG
(US9994546, Example 84 | [1-[(1-hydroxycyclopropyl)...)
Show SMILES OC1(CC1)C(=O)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H30N4O2/c24-11-10-22(15-26(16-22)21(28)23(29)8-9-23)27-12-6-18(7-13-27)25-20-14-19(20)17-4-2-1-3-5-17/h1-5,18-20,25,29H,6-10,12-16H2/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397594
PNG
(2-[1-(methylsulfonyl)-3-(4-{[(1R,2S)-2-phenylcyclo...)
Show SMILES CS(=O)(=O)N1CC(CCO)(C1)C1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C21H32N2O3S/c1-27(25,26)23-14-21(15-23,11-12-24)17-7-9-18(10-8-17)22-20-13-19(20)16-5-3-2-4-6-16/h2-6,17-20,22,24H,7-15H2,1H3/t17?,18?,19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397604
PNG
(US9994546, Example 103 | US9994546, Example 104 | ...)
Show SMILES OC1CCC(CC1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccc(F)cc1
Show InChI InChI=1S/C25H35FN4O/c26-19-3-1-18(2-4-19)23-15-24(23)28-20-9-13-30(14-10-20)25(11-12-27)16-29(17-25)21-5-7-22(31)8-6-21/h1-4,20-24,28,31H,5-11,13-17H2/t21?,22?,23?,24-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397608
PNG
(2-(3-(4-(((1R,2S)-2-phenylcyclopropyl)amino)piperi...)
Show SMILES O=C(C1CCCO1)N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C24H32N4O2/c25-11-10-24(16-27(17-24)23(29)22-7-4-14-30-22)28-12-8-19(9-13-28)26-21-15-20(21)18-5-2-1-3-6-18/h1-3,5-6,19-22,26H,4,7-10,12-17H2/t20?,21-,22?/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397614
PNG
(US9994546, Example 113 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C(N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1)c1ccn[nH]1
Show InChI InChI=1/C23H28N6O/c24-10-9-23(15-28(16-23)22(30)20-6-11-25-27-20)29-12-7-18(8-13-29)26-21-14-19(21)17-4-2-1-3-5-17/h1-6,11,18-19,21,26H,7-9,12-16H2,(H,25,27)/t19?,21-/s2
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397621
PNG
(US9994546, Example 120 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES O=C(N1CC(CC#N)(C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1)c1nccs1
Show InChI InChI=1S/C23H27N5OS/c24-9-8-23(15-27(16-23)22(29)21-25-10-13-30-21)28-11-6-18(7-12-28)26-20-14-19(20)17-4-2-1-3-5-17/h1-5,10,13,18-20,26H,6-8,11-12,14-16H2/t19?,20-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397628
PNG
(US9994546, Example 127 | [3-(4-{[(1R,2S)-2-phenylc...)
Show SMILES OC(=O)CC1(CN(Cc2cscn2)C1)N1CCC(CC1)N[C@@H]1CC1c1ccccc1
Show InChI InChI=1S/C23H30N4O2S/c28-22(29)11-23(14-26(15-23)12-19-13-30-16-24-19)27-8-6-18(7-9-27)25-21-10-20(21)17-4-2-1-3-5-17/h1-5,13,16,18,20-21,25H,6-12,14-15H2,(H,28,29)/t20?,21-/m1/s1
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397512
PNG
(3-Cyano-4-(3-(cyanomethyl)-3-{4-[(trans-2-phenylcy...)
Show SMILES OC(=O)c1ccc(N2CC(CC#N)(C2)N2CCC(CC2)NC2CC2c2ccccc2)c(c1)C#N
Show InChI InChI=1S/C27H29N5O2/c28-11-10-27(17-31(18-27)25-7-6-20(26(33)34)14-21(25)16-29)32-12-8-22(9-13-32)30-24-15-23(24)19-4-2-1-3-5-19/h1-7,14,22-24,30H,8-10,12-13,15,17-18H2,(H,33,34)
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
Lysine-specific histone demethylase 1A


(Homo sapiens (Human))
BDBM397532
PNG
(US9994546, Example 31 | [1-(Ethylsulfonyl)-3-(4-{[...)
Show SMILES CCS(=O)(=O)N1CC(CC#N)(C1)N1CCC(CNC2CC2c2ccccc2)CC1
Show InChI InChI=1S/C22H32N4O2S/c1-2-29(27,28)26-16-22(17-26,10-11-23)25-12-8-18(9-13-25)15-24-21-14-20(21)19-6-4-3-5-7-19/h3-7,18,20-21,24H,2,8-10,12-17H2,1H3
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Assay Description
LANCE LSD1/KDM1A demethylase assay 10 μL of 1 nM LSD-1 enzyme (ENZO BML-SE544-0050) in the assay buffer (50 mM Tris, pH 7.5, 0.01% Tween-20, 25 ...


US Patent US9994546 (2018)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%