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Patent code US9994552

Compile Data Set for Download or QSAR

Found 278 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kJ/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397818
PNG
(US9994552, Compound 29)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OC
Show InChI InChI=1S/C25H27N7O2/c1-33-21-13-19-20(14-22(21)34-2)28-16-29-24(19)31-8-10-32(11-9-31)25-27-15-18(23(26)30-25)12-17-6-4-3-5-7-17/h3-7,13-16H,8-12H2,1-2H3,(H2,26,27,30)
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397846
PNG
(US9994552, Compound 57)
Show SMILES COc1cccc(Cc2cnc(nc2)N2CCN(CC2)c2ncnc3cc(OC)c(OC)cc23)c1
Show InChI InChI=1S/C26H28N6O3/c1-33-20-6-4-5-18(12-20)11-19-15-27-26(28-16-19)32-9-7-31(8-10-32)25-21-13-23(34-2)24(35-3)14-22(21)29-17-30-25/h4-6,12-17H,7-11H2,1-3H3
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BLUEPRINT MEDICINES CORPORATION

US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397898
PNG
(US9994552, Compound 109)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCNC(=O)C1
Show InChI InChI=1S/C30H33N7O3/c1-39-26-16-25-24(15-27(26)40-19-22-7-8-31-28(38)14-22)29(35-20-34-25)36-9-11-37(12-10-36)30-32-17-23(18-33-30)13-21-5-3-2-4-6-21/h2-6,15-18,20,22H,7-14,19H2,1H3,(H,31,38)
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397899
PNG
(US9994552, Compound 110)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCN1CCCC1=O
Show InChI InChI=1S/C30H33N7O3/c1-39-26-18-25-24(17-27(26)40-15-14-35-9-5-8-28(35)38)29(34-21-33-25)36-10-12-37(13-11-36)30-31-19-23(20-32-30)16-22-6-3-2-4-7-22/h2-4,6-7,17-21H,5,8-16H2,1H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397901
PNG
(US9994552, Compound 112)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H37N7O2/c1-36-10-8-24(9-11-36)21-40-29-17-26-27(18-28(29)39-2)34-22-35-30(26)37-12-14-38(15-13-37)31-32-19-25(20-33-31)16-23-6-4-3-5-7-23/h3-7,17-20,22,24H,8-16,21H2,1-2H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397902
PNG
(US9994552, Compound 113)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OC[C@@H]1CCCN(C)C1
Show InChI InChI=1S/C31H37N7O2/c1-36-10-6-9-24(20-36)21-40-29-16-26-27(17-28(29)39-2)34-22-35-30(26)37-11-13-38(14-12-37)31-32-18-25(19-33-31)15-23-7-4-3-5-8-23/h3-5,7-8,16-19,22,24H,6,9-15,20-21H2,1-2H3/t24-/m1/s1
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397924
PNG
(US9994552, Compound 135)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H40N8O2/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-38(2)12-10-24)31(36-22-35-27)39-13-15-40(16-14-39)32-34-20-25(30(33)37-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H2,33,34,37)
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397927
PNG
(US9994552, Compound 138)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O3/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-37(2)12-10-24)30(35-22-34-27)38-13-15-39(16-14-38)32-33-20-25(31(40)36-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H,33,36,40)
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US Patent


Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397879
PNG
(US9994552, Compound 90)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CN(C)C1
Show InChI InChI=1S/C29H33N7O2/c1-34-17-23(18-34)19-38-27-13-24-25(14-26(27)37-2)32-20-33-28(24)35-8-10-36(11-9-35)29-30-15-22(16-31-29)12-21-6-4-3-5-7-21/h3-7,13-16,20,23H,8-12,17-19H2,1-2H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397885
PNG
(US9994552, Compound 96)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)C1
Show InChI InChI=1S/C30H35N7O2/c1-35-9-8-23(19-35)20-39-28-15-25-26(16-27(28)38-2)33-21-34-29(25)36-10-12-37(13-11-36)30-31-17-24(18-32-30)14-22-6-4-3-5-7-22/h3-7,15-18,21,23H,8-14,19-20H2,1-2H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397906
PNG
(US9994552, Compound 117)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CN(C)CCO1
Show InChI InChI=1S/C30H35N7O3/c1-35-12-13-39-24(19-35)20-40-28-15-25-26(16-27(28)38-2)33-21-34-29(25)36-8-10-37(11-9-36)30-31-17-23(18-32-30)14-22-6-4-3-5-7-22/h3-7,15-18,21,24H,8-14,19-20H2,1-2H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397910
PNG
(US9994552, Compound 121)
Show SMILES COc1cc2ncnc(N3CC4CCC(C3)N4c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CNCCO1
Show InChI InChI=1S/C31H35N7O3/c1-39-28-13-27-26(12-29(28)41-19-25-16-32-9-10-40-25)30(36-20-35-27)37-17-23-7-8-24(18-37)38(23)31-33-14-22(15-34-31)11-21-5-3-2-4-6-21/h2-6,12-15,20,23-25,32H,7-11,16-19H2,1H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397925
PNG
(US9994552, Compound 136)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCCN1CCN(C)CC1
Show InChI InChI=1S/C32H40N8O2/c1-37-10-12-38(13-11-37)9-6-18-42-30-20-27-28(21-29(30)41-2)35-24-36-31(27)39-14-16-40(17-15-39)32-33-22-26(23-34-32)19-25-7-4-3-5-8-25/h3-5,7-8,20-24H,6,9-19H2,1-2H3
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Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397818
PNG
(US9994552, Compound 29)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OC
Show InChI InChI=1S/C25H27N7O2/c1-33-21-13-19-20(14-22(21)34-2)28-16-29-24(19)31-8-10-32(11-9-31)25-27-15-18(23(26)30-25)12-17-6-4-3-5-7-17/h3-7,13-16H,8-12H2,1-2H3,(H2,26,27,30)
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397887
PNG
(US9994552, Compound 98)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCNCC1
Show InChI InChI=1S/C30H35N7O2/c1-38-27-17-26-25(16-28(27)39-20-23-7-9-31-10-8-23)29(35-21-34-26)36-11-13-37(14-12-36)30-32-18-24(19-33-30)15-22-5-3-2-4-6-22/h2-6,16-19,21,23,31H,7-15,20H2,1H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397897
PNG
(US9994552, Compound 108)
Show SMILES COCCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCOC
Show InChI InChI=1S/C29H34N6O4/c1-36-12-14-38-26-17-24-25(18-27(26)39-15-13-37-2)32-21-33-28(24)34-8-10-35(11-9-34)29-30-19-23(20-31-29)16-22-6-4-3-5-7-22/h3-7,17-21H,8-16H2,1-2H3
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397908
PNG
(US9994552, Compound 119)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CNCCO1
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397913
PNG
(US9994552, Compound 124)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OC[C@@H]1CCCN(C)C1
Show InChI InChI=1S/C31H38N8O2/c1-37-10-6-9-23(19-37)20-41-28-16-25-26(17-27(28)40-2)34-21-35-30(25)38-11-13-39(14-12-38)31-33-18-24(29(32)36-31)15-22-7-4-3-5-8-22/h3-5,7-8,16-18,21,23H,6,9-15,19-20H2,1-2H3,(H2,32,33,36)/t23-/m1/s1
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397916
PNG
(US9994552, Compound 127)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H37N7O3/c1-36-10-8-23(9-11-36)20-41-28-17-25-26(18-27(28)40-2)33-21-34-29(25)37-12-14-38(15-13-37)31-32-19-24(30(39)35-31)16-22-6-4-3-5-7-22/h3-7,17-19,21,23H,8-16,20H2,1-2H3,(H,32,35,39)
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397919
PNG
(US9994552, Compound 130)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CN(C)CCO1
PDB

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US Patent


Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397927
PNG
(US9994552, Compound 138)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O3/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-37(2)12-10-24)30(35-22-34-27)38-13-15-39(16-14-38)32-33-20-25(31(40)36-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H,33,36,40)
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397824
PNG
(US9994552, Compound 35)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(O)n3)c2cc1OC
Show InChI InChI=1S/C25H26N6O3/c1-33-21-13-19-20(14-22(21)34-2)27-16-28-23(19)30-8-10-31(11-9-30)25-26-15-18(24(32)29-25)12-17-6-4-3-5-7-17/h3-7,13-16H,8-12H2,1-2H3,(H,26,29,32)
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397908
PNG
(US9994552, Compound 119)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CNCCO1
PDB

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US Patent


Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397911
PNG
(US9994552, Compound 122)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O2/c1-3-40-30-19-28-27(18-29(30)41-22-25-9-11-37(2)12-10-25)31(36-23-35-28)38-13-15-39(16-14-38)32-33-20-26(21-34-32)17-24-7-5-4-6-8-24/h4-8,18-21,23,25H,3,9-17,22H2,1-2H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397913
PNG
(US9994552, Compound 124)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OC[C@@H]1CCCN(C)C1
Show InChI InChI=1S/C31H38N8O2/c1-37-10-6-9-23(19-37)20-41-28-16-25-26(17-27(28)40-2)34-21-35-30(25)38-11-13-39(14-12-38)31-33-18-24(29(32)36-31)15-22-7-4-3-5-8-22/h3-5,7-8,16-18,21,23H,6,9-15,19-20H2,1-2H3,(H2,32,33,36)/t23-/m1/s1
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US Patent


Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397920
PNG
(US9994552, Compound 131)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1(F)CCN(C)CC1
Show InChI InChI=1S/C31H36FN7O2/c1-37-10-8-31(32,9-11-37)21-41-28-17-25-26(18-27(28)40-2)35-22-36-29(25)38-12-14-39(15-13-38)30-33-19-24(20-34-30)16-23-6-4-3-5-7-23/h3-7,17-20,22H,8-16,21H2,1-2H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397878
PNG
(US9994552, Compound 89)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCNC1
Show InChI InChI=1S/C29H33N7O2/c1-37-26-15-25-24(14-27(26)38-19-22-7-8-30-16-22)28(34-20-33-25)35-9-11-36(12-10-35)29-31-17-23(18-32-29)13-21-5-3-2-4-6-21/h2-6,14-15,17-18,20,22,30H,7-13,16,19H2,1H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397894
PNG
(US9994552, Compound 105)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CNCCO1
Show InChI InChI=1S/C29H33N7O3/c1-37-26-15-25-24(14-27(26)39-19-23-18-30-7-12-38-23)28(34-20-33-25)35-8-10-36(11-9-35)29-31-16-22(17-32-29)13-21-5-3-2-4-6-21/h2-6,14-17,20,23,30H,7-13,18-19H2,1H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397897
PNG
(US9994552, Compound 108)
Show SMILES COCCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCOC
Show InChI InChI=1S/C29H34N6O4/c1-36-12-14-38-26-17-24-25(18-27(26)39-15-13-37-2)32-21-33-28(24)34-8-10-35(11-9-34)29-30-19-23(20-31-29)16-22-6-4-3-5-7-22/h3-7,17-21H,8-16H2,1-2H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397903
PNG
(US9994552, Compound 114)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCCN(C)C1
Show InChI InChI=1S/C31H37N7O2/c1-36-10-6-9-24(20-36)21-40-29-16-26-27(17-28(29)39-2)34-22-35-30(26)37-11-13-38(14-12-37)31-32-18-25(19-33-31)15-23-7-4-3-5-8-23/h3-5,7-8,16-19,22,24H,6,9-15,20-21H2,1-2H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397911
PNG
(US9994552, Compound 122)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H39N7O2/c1-3-40-30-19-28-27(18-29(30)41-22-25-9-11-37(2)12-10-25)31(36-23-35-28)38-13-15-39(16-14-38)32-33-20-26(21-34-32)17-24-7-5-4-6-8-24/h4-8,18-21,23,25H,3,9-17,22H2,1-2H3
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US Patent


Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397914
PNG
(US9994552, Compound 125)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H38N8O2/c1-37-10-8-23(9-11-37)20-41-28-17-25-26(18-27(28)40-2)34-21-35-30(25)38-12-14-39(15-13-38)31-33-19-24(29(32)36-31)16-22-6-4-3-5-7-22/h3-7,17-19,21,23H,8-16,20H2,1-2H3,(H2,32,33,36)
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397916
PNG
(US9994552, Compound 127)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H37N7O3/c1-36-10-8-23(9-11-36)20-41-28-17-25-26(18-27(28)40-2)33-21-34-29(25)37-12-14-38(15-13-37)31-32-19-24(30(39)35-31)16-22-6-4-3-5-7-22/h3-7,17-19,21,23H,8-16,20H2,1-2H3,(H,32,35,39)
PDB

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US Patent


Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397923
PNG
(US9994552, Compound 134)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCN(C)CC1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C32H40N8O2/c1-37-10-12-38(13-11-37)9-6-18-42-30-21-28-27(20-29(30)41-2)31(36-24-35-28)39-14-16-40(17-15-39)32-33-22-26(23-34-32)19-25-7-4-3-5-8-25/h3-5,7-8,20-24H,6,9-19H2,1-2H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397924
PNG
(US9994552, Compound 135)
Show SMILES CCOc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C32H40N8O2/c1-3-41-29-19-27-26(18-28(29)42-21-24-9-11-38(2)12-10-24)31(36-22-35-27)39-13-15-40(16-14-39)32-34-20-25(30(33)37-32)17-23-7-5-4-6-8-23/h4-8,18-20,22,24H,3,9-17,21H2,1-2H3,(H2,33,34,37)
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397893
PNG
(US9994552, Compound 104)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OC[C@H]1CNCCO1
Show InChI InChI=1S/C29H33N7O3/c1-37-26-15-25-24(14-27(26)39-19-23-18-30-7-12-38-23)28(34-20-33-25)35-8-10-36(11-9-35)29-31-16-22(17-32-29)13-21-5-3-2-4-6-21/h2-6,14-17,20,23,30H,7-13,18-19H2,1H3/t23-/m1/s1
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397900
PNG
(US9994552, Compound 111)
Show SMILES COc1cc2c(ncnc2cc1OCCN1CCCC1=O)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C30H33N7O3/c1-39-26-17-24-25(18-27(26)40-15-14-35-9-5-8-28(35)38)33-21-34-29(24)36-10-12-37(13-11-36)30-31-19-23(20-32-30)16-22-6-3-2-4-7-22/h2-4,6-7,17-21H,5,8-16H2,1H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397909
PNG
(US9994552, Compound 120)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OC[C@H]1CNCCO1
PDB

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US Patent


Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397824
PNG
(US9994552, Compound 35)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(O)n3)c2cc1OC
Show InChI InChI=1S/C25H26N6O3/c1-33-21-13-19-20(14-22(21)34-2)27-16-28-23(19)30-8-10-31(11-9-30)25-26-15-18(24(32)29-25)12-17-6-4-3-5-7-17/h3-7,13-16H,8-12H2,1-2H3,(H,26,29,32)
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397886
PNG
(US9994552, Compound 97)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCCNC1
Show InChI InChI=1S/C30H35N7O2/c1-38-27-16-26-25(15-28(27)39-20-23-8-5-9-31-17-23)29(35-21-34-26)36-10-12-37(13-11-36)30-32-18-24(19-33-30)14-22-6-3-2-4-7-22/h2-4,6-7,15-16,18-19,21,23,31H,5,8-14,17,20H2,1H3
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US Patent


Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Mast/stem cell growth factor receptor Kit


(Homo sapiens (Human))		BDBM397909
PNG
(US9994552, Compound 120)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OC[C@H]1CNCCO1
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Assay Description
Kit wild type assay: In each well of a 384-well plate, 0.2 ng/ul final (2 nM) of wild type Kit (Carna Bioscience 08-156) was incubated in a total of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397914
PNG
(US9994552, Compound 125)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(N)n3)c2cc1OCC1CCN(C)CC1
Show InChI InChI=1S/C31H38N8O2/c1-37-10-8-23(9-11-37)20-41-28-17-25-26(18-27(28)40-2)34-21-35-30(25)38-12-14-39(15-13-38)31-33-19-24(29(32)36-31)16-22-6-4-3-5-7-22/h3-7,17-19,21,23H,8-16,20H2,1-2H3,(H2,32,33,36)
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397920
PNG
(US9994552, Compound 131)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1(F)CCN(C)CC1
Show InChI InChI=1S/C31H36FN7O2/c1-37-10-8-31(32,9-11-37)21-41-28-17-25-26(18-27(28)40-2)35-22-36-29(25)38-12-14-39(15-13-38)30-33-19-24(20-34-30)16-23-6-4-3-5-7-23/h3-7,17-20,22H,8-16,21H2,1-2H3
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397923
PNG
(US9994552, Compound 134)
Show SMILES COc1cc2c(ncnc2cc1OCCCN1CCN(C)CC1)N1CCN(CC1)c1ncc(Cc2ccccc2)cn1
Show InChI InChI=1S/C32H40N8O2/c1-37-10-12-38(13-11-37)9-6-18-42-30-21-28-27(20-29(30)41-2)31(36-24-35-28)39-14-16-40(17-15-39)32-33-22-26(23-34-32)19-25-7-4-3-5-8-25/h3-5,7-8,20-24H,6,9-19H2,1-2H3
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397825
PNG
(US9994552, Compound 36)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(COc4ccccc4)cn3)c2cc1OC
Show InChI InChI=1S/C25H26N6O3/c1-32-22-12-20-21(13-23(22)33-2)28-17-29-24(20)30-8-10-31(11-9-30)25-26-14-18(15-27-25)16-34-19-6-4-3-5-7-19/h3-7,12-15,17H,8-11,16H2,1-2H3
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397905
PNG
(US9994552, Compound 116)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCCN1CCNCC1
Show InChI InChI=1S/C30H36N8O2/c1-39-27-19-26-25(18-28(27)40-16-15-36-9-7-31-8-10-36)29(35-22-34-26)37-11-13-38(14-12-37)30-32-20-24(21-33-30)17-23-5-3-2-4-6-23/h2-6,18-22,31H,7-17H2,1H3
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397917
PNG
(US9994552, Compound 128)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)c(=O)[nH]3)c2cc1OC[C@@H]1CCCN(C)C1
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397812
PNG
(US9994552, Compound 23 | US9994552, Compound 26)
Show SMILES COc1cc2ncnc(N3CCN(C(C)C3)c3ncc(Cc4ccccc4)cn3)c2cc1OC
Show InChI InChI=1S/C26H28N6O2/c1-18-16-31(25-21-12-23(33-2)24(34-3)13-22(21)29-17-30-25)9-10-32(18)26-27-14-20(15-28-26)11-19-7-5-4-6-8-19/h4-8,12-15,17-18H,9-11,16H2,1-3H3
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397878
PNG
(US9994552, Compound 89)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OCC1CCNC1
Show InChI InChI=1S/C29H33N7O2/c1-37-26-15-25-24(14-27(26)38-19-22-7-8-30-16-22)28(34-20-33-25)35-9-11-36(12-10-35)29-31-17-23(18-32-29)13-21-5-3-2-4-6-21/h2-6,14-15,17-18,20,22,30H,7-13,16,19H2,1H3
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
Tyrosine-protein kinase Kit (Kit)(D816V)


(Homo sapiens (Human))		BDBM397895
PNG
(US9994552, Compound 106)
Show SMILES COc1cc2ncnc(N3CCN(CC3)c3ncc(Cc4ccccc4)cn3)c2cc1OC[C@@H]1CNCCO1
Show InChI InChI=1S/C29H33N7O3/c1-37-26-15-25-24(14-27(26)39-19-23-18-30-7-12-38-23)28(34-20-33-25)35-8-10-36(11-9-35)29-31-16-22(17-32-29)13-21-5-3-2-4-6-21/h2-6,14-17,20,23,30H,7-13,18-19H2,1H3/t23-/m0/s1
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Assay Description
Kit D816V assay: In each well of a 384-well plate, 0.04 ng/ul (0.5 nM) of D816V Kit (Carna Bioscience 08-156) was incubated in a total of 12.5 ul of ...

US Patent US9994552 (2018)


Article DOI: null
BindingDB Entry DOI: 10.7270/Q27M0B8Q
More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%