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Patent code USRE46942

Compile Data Set for Download or QSAR
Found 106 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185805
PNG
(US9163003, 13 | USRE46942, Example 13)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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n/an/a 3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM404370
PNG
(2-{(S)-3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2cc3ccccc(=O)c3[nH]2)C1=O
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n/an/a 5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185805
PNG
(US9163003, 13 | USRE46942, Example 13)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 6n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185802
PNG
(US9163003, 10 | USRE46942, Example 10)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 6n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185816
PNG
(US9163003, 28 | USRE46942, Example 28)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3ccccc(=O)c3[nH]2)C1=O
PDB

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n/an/a 7n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185826
PNG
(US9163003, 17 | USRE46942, Example 16)
Show SMILES COc1ccc2C(=O)C3(Cc2c1)CCN(CC3)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C26H30N4O5/c1-34-17-2-3-18-16(12-17)13-26(23(18)31)6-9-29(10-7-26)21-4-8-30(25(21)33)14-22-27-20-5-11-35-15-19(20)24(32)28-22/h2-3,12,21H,4-11,13-15H2,1H3,(H,27,28,32)/t21-/m1/s1
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n/an/a<8.60n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM404359
PNG
(USRE46942, Example 19)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 9n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM404370
PNG
(2-{(S)-3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2cc3ccccc(=O)c3[nH]2)C1=O
PDB

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n/an/a 9.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185795
PNG
(US9163003, 3 | USRE46942, Example 3)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 9.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185826
PNG
(US9163003, 17 | USRE46942, Example 16)
Show SMILES COc1ccc2C(=O)C3(Cc2c1)CCN(CC3)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C26H30N4O5/c1-34-17-2-3-18-16(12-17)13-26(23(18)31)6-9-29(10-7-26)21-4-8-30(25(21)33)14-22-27-20-5-11-35-15-19(20)24(32)28-22/h2-3,12,21H,4-11,13-15H2,1H3,(H,27,28,32)/t21-/m1/s1
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n/an/a 12n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185795
PNG
(US9163003, 3 | USRE46942, Example 3)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 12.8n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185794
PNG
(US9163003, 2 | USRE46942, Example 2)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 15n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185797
PNG
(US9163003, 5 | USRE46942, Example 5)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2ccc(Cl)c(c2)C#N)C1=O
Show InChI InChI=1S/C25H26ClN3O3/c1-32-21-5-3-18(4-6-21)24(30)19-8-11-28(12-9-19)23-10-13-29(25(23)31)16-17-2-7-22(26)20(14-17)15-27/h2-7,14,19,23H,8-13,16H2,1H3
PDB

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n/an/a 15n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185808
PNG
(US9163003, 18 | USRE46942, Example 18)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 15n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185827
PNG
(US9163003, 33 | USRE46942, Example 34)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(CC(=O)Nc2nnc3SCCn23)C1=O
Show InChI InChI=1S/C23H28N6O4S/c1-33-17-4-2-15(3-5-17)20(31)16-6-9-27(10-7-16)18-8-11-28(21(18)32)14-19(30)24-22-25-26-23-29(22)12-13-34-23/h2-5,16,18H,6-14H2,1H3,(H,24,25,30)/t18-/m0/s1
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n/an/a 16n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185809
PNG
(US9163003, 21 | USRE46942, Example 21)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 17n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185803
PNG
(US9163003, 11 | USRE46942, Example 11)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 17n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185807
PNG
(US9163003, 15 | USRE46942, Example 15)
Show SMILES COc1ccc2C(=O)C3(Cc2c1)CCN(CC3)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 18n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM404367
PNG
(2-((3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopy...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2cc3ccccc(=O)c3[nH]2)C1=O
PDB

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n/an/a 19n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185816
PNG
(US9163003, 28 | USRE46942, Example 28)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3ccccc(=O)c3[nH]2)C1=O
PDB

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n/an/a 19.5n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185820
PNG
(US9163003, 32 | USRE46942, Example 32)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2nnc3SCCn23)C1=O
Show InChI InChI=1S/C23H28N6O4S/c1-33-17-4-2-15(3-5-17)20(31)16-6-9-27(10-7-16)18-8-11-28(21(18)32)14-19(30)24-22-25-26-23-29(22)12-13-34-23/h2-5,16,18H,6-14H2,1H3,(H,24,25,30)
PDB

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n/an/a 21n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185798
PNG
(US9163003, 6 | USRE46942, Example 6)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3n(C)ncc3c(=O)[nH]2)C1=O
PDB

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n/an/a 22n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185801
PNG
(US9163003, 9 | USRE46942, Example 9)
Show SMILES Clc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 23n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM404359
PNG
(USRE46942, Example 19)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 24n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185798
PNG
(US9163003, 6 | USRE46942, Example 6)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3n(C)ncc3c(=O)[nH]2)C1=O
PDB

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n/an/a 25n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185814
PNG
(US9163003, 26 | USRE46942, Example 26)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc(C)c(C)c(=O)[nH]2)C1=O
PDB

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n/an/a 26n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185802
PNG
(US9163003, 10 | USRE46942, Example 10)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 27n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185801
PNG
(US9163003, 9 | USRE46942, Example 9)
Show SMILES Clc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 30n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185807
PNG
(US9163003, 15 | USRE46942, Example 15)
Show SMILES COc1ccc2C(=O)C3(Cc2c1)CCN(CC3)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 33n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185794
PNG
(US9163003, 2 | USRE46942, Example 2)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 33n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185809
PNG
(US9163003, 21 | USRE46942, Example 21)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 34n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185813
PNG
(US9163003, 25 | USRE46942, Example 25)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2ncc(C)c(=O)[nH]2)C1=O
PDB

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n/an/a 36n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185797
PNG
(US9163003, 5 | USRE46942, Example 5)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2ccc(Cl)c(c2)C#N)C1=O
Show InChI InChI=1S/C25H26ClN3O3/c1-32-21-5-3-18(4-6-21)24(30)19-8-11-28(12-9-19)23-10-13-29(25(23)31)16-17-2-7-22(26)20(14-17)15-27/h2-7,14,19,23H,8-13,16H2,1H3
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n/an/a 36n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM404367
PNG
(2-((3-(4-(4-methoxybenzoyl)piperidin-1-yl)-2-oxopy...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2cc3ccccc(=O)c3[nH]2)C1=O
PDB

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n/an/a 36n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185803
PNG
(US9163003, 11 | USRE46942, Example 11)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 37n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185827
PNG
(US9163003, 33 | USRE46942, Example 34)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(CC(=O)Nc2nnc3SCCn23)C1=O
Show InChI InChI=1S/C23H28N6O4S/c1-33-17-4-2-15(3-5-17)20(31)16-6-9-27(10-7-16)18-8-11-28(21(18)32)14-19(30)24-22-25-26-23-29(22)12-13-34-23/h2-5,16,18H,6-14H2,1H3,(H,24,25,30)/t18-/m0/s1
PDB

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n/an/a 38n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185820
PNG
(US9163003, 32 | USRE46942, Example 32)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2nnc3SCCn23)C1=O
Show InChI InChI=1S/C23H28N6O4S/c1-33-17-4-2-15(3-5-17)20(31)16-6-9-27(10-7-16)18-8-11-28(21(18)32)14-19(30)24-22-25-26-23-29(22)12-13-34-23/h2-5,16,18H,6-14H2,1H3,(H,24,25,30)
PDB

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n/an/a 43n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185808
PNG
(US9163003, 18 | USRE46942, Example 18)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 46n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185814
PNG
(US9163003, 26 | USRE46942, Example 26)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc(C)c(C)c(=O)[nH]2)C1=O
PDB

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n/an/a 47n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185812
PNG
(US9163003, 24 | USRE46942, Example 24)
Show SMILES CCc1cc(=O)[nH]c(CN2CCC(N3CCC(CC3)C(=O)c3ccc(OC)cc3)C2=O)n1
PDB

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n/an/a 53n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185813
PNG
(US9163003, 25 | USRE46942, Example 25)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2ncc(C)c(=O)[nH]2)C1=O
PDB

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n/an/a 72n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM404341
PNG
(2-Chloro-6-{3-[4-(4-methoxy-benzoyl)-piperidin-1-y...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2cccc(Cl)c2C#N)C1=O
Show InChI InChI=1S/C25H26ClN3O3/c1-32-20-7-5-17(6-8-20)24(30)18-9-12-28(13-10-18)23-11-14-29(25(23)31)16-19-3-2-4-22(26)21(19)15-27/h2-8,18,23H,9-14,16H2,1H3
PDB

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n/an/a 81n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185799
PNG
(US9163003, 7 | USRE46942, Example 7)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3ccsc3c(=O)[nH]2)C1=O
PDB

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n/an/a 83n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185800
PNG
(US9163003, 8 | USRE46942, Example 8)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3sc(C)cc3c(=O)[nH]2)C1=O
PDB

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n/an/a 96n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185817
PNG
(US9163003, 29 | USRE46942, Example 29)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3ccccc(=O)c3[nH]2)C1=O
PDB

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n/an/a 112n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185812
PNG
(US9163003, 24 | USRE46942, Example 24)
Show SMILES CCc1cc(=O)[nH]c(CN2CCC(N3CCC(CC3)C(=O)c3ccc(OC)cc3)C2=O)n1
PDB

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n/an/a 115n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185811
PNG
(US9163003, 23 | USRE46942, Example 23)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc(C)cc(=O)[nH]2)C1=O
PDB

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n/an/a 137n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185800
PNG
(US9163003, 8 | USRE46942, Example 8)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3sc(C)cc3c(=O)[nH]2)C1=O
PDB

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n/an/a 141n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM404341
PNG
(2-Chloro-6-{3-[4-(4-methoxy-benzoyl)-piperidin-1-y...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2cccc(Cl)c2C#N)C1=O
Show InChI InChI=1S/C25H26ClN3O3/c1-32-20-7-5-17(6-8-20)24(30)18-9-12-28(13-10-18)23-11-14-29(25(23)31)16-19-3-2-4-22(26)21(19)15-27/h2-8,18,23H,9-14,16H2,1H3
PDB

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n/an/a 162n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185806
PNG
(US9163003, 14 | USRE46942, Example 14)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 206n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185799
PNG
(US9163003, 7 | USRE46942, Example 7)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3ccsc3c(=O)[nH]2)C1=O
PDB

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n/an/a 211n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM404360
PNG
(USRE46942, Example 20)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 218n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185817
PNG
(US9163003, 29 | USRE46942, Example 29)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3ccccc(=O)c3[nH]2)C1=O
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n/an/a 278n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185811
PNG
(US9163003, 23 | USRE46942, Example 23)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc(C)cc(=O)[nH]2)C1=O
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n/an/a 286n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185828
PNG
(US9163003, 34 | USRE46942, Example 33)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(CC(=O)Nc2nnc3SCCn23)C1=O
Show InChI InChI=1S/C23H28N6O4S/c1-33-17-4-2-15(3-5-17)20(31)16-6-9-27(10-7-16)18-8-11-28(21(18)32)14-19(30)24-22-25-26-23-29(22)12-13-34-23/h2-5,16,18H,6-14H2,1H3,(H,24,25,30)/t18-/m1/s1
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n/an/a 374n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM404371
PNG
(2-{(R)-3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2cc3ccccc(=O)c3[nH]2)C1=O
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n/an/a 390n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM404360
PNG
(USRE46942, Example 20)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 483n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185796
PNG
(US9163003, 4 | USRE46942, Example 4)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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n/an/a 600n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185821
PNG
(US9163003, 35 | USRE46942, Example 35)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2nnc3ccccn23)C1=O
Show InChI InChI=1S/C25H28N6O4/c1-35-19-7-5-17(6-8-19)23(33)18-9-13-29(14-10-18)20-11-15-30(24(20)34)16-22(32)26-25-28-27-21-4-2-3-12-31(21)25/h2-8,12,18,20H,9-11,13-16H2,1H3,(H,26,28,32)
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n/an/a 636n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185806
PNG
(US9163003, 14 | USRE46942, Example 14)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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n/an/a 711n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185810
PNG
(US9163003, 22 | USRE46942, Example 22)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nccc(=O)[nH]2)C1=O
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n/an/a 764n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185828
PNG
(US9163003, 34 | USRE46942, Example 33)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(CC(=O)Nc2nnc3SCCn23)C1=O
Show InChI InChI=1S/C23H28N6O4S/c1-33-17-4-2-15(3-5-17)20(31)16-6-9-27(10-7-16)18-8-11-28(21(18)32)14-19(30)24-22-25-26-23-29(22)12-13-34-23/h2-5,16,18H,6-14H2,1H3,(H,24,25,30)/t18-/m1/s1
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n/an/a 830n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185823
PNG
(US9163003, 37 | USRE46942, Example 37)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2nncc3OCCCc23)C1=O
Show InChI InChI=1S/C26H31N5O5/c1-35-19-6-4-17(5-7-19)24(33)18-8-11-30(12-9-18)21-10-13-31(26(21)34)16-23(32)28-25-20-3-2-14-36-22(20)15-27-29-25/h4-7,15,18,21H,2-3,8-14,16H2,1H3,(H,28,29,32)
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n/an/a 970n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM404371
PNG
(2-{(R)-3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2cc3ccccc(=O)c3[nH]2)C1=O
PDB

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Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185822
PNG
(US9163003, 36 | USRE46942, Example 36)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2nnnn2C)C1=O
Show InChI InChI=1S/C21H27N7O4/c1-26-21(23-24-25-26)22-18(29)13-28-12-9-17(20(28)31)27-10-7-15(8-11-27)19(30)14-3-5-16(32-2)6-4-14/h3-6,15,17H,7-13H2,1-2H3,(H,22,23,25,29)
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Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185810
PNG
(US9163003, 22 | USRE46942, Example 22)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nccc(=O)[nH]2)C1=O
PDB

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n/an/a 1.50E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185796
PNG
(US9163003, 4 | USRE46942, Example 4)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 1.60E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185825
PNG
(US9163003, 16 | USRE46942, Example 17)
Show SMILES COc1ccc2C(=O)C3(Cc2c1)CCN(CC3)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C26H30N4O5/c1-34-17-2-3-18-16(12-17)13-26(23(18)31)6-9-29(10-7-26)21-4-8-30(25(21)33)14-22-27-20-5-11-35-15-19(20)24(32)28-22/h2-3,12,21H,4-11,13-15H2,1H3,(H,27,28,32)/t21-/m0/s1
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n/an/a 1.72E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM185804
PNG
(US9163003, 12 | USRE46942, Example 12)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 2.12E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185821
PNG
(US9163003, 35 | USRE46942, Example 35)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2nnc3ccccn23)C1=O
Show InChI InChI=1S/C25H28N6O4/c1-35-19-7-5-17(6-8-19)23(33)18-9-13-29(14-10-18)20-11-15-30(24(20)34)16-22(32)26-25-28-27-21-4-2-3-12-31(21)25/h2-8,12,18,20H,9-11,13-16H2,1H3,(H,26,28,32)
PDB

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n/an/a 2.47E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185816
PNG
(US9163003, 28 | USRE46942, Example 28)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3ccccc(=O)c3[nH]2)C1=O
PDB

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n/an/a 2.90E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185823
PNG
(US9163003, 37 | USRE46942, Example 37)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2nncc3OCCCc23)C1=O
Show InChI InChI=1S/C26H31N5O5/c1-35-19-6-4-17(5-7-19)24(33)18-8-11-30(12-9-18)21-10-13-31(26(21)34)16-23(32)28-25-20-3-2-14-36-22(20)15-27-29-25/h4-7,15,18,21H,2-3,8-14,16H2,1H3,(H,28,29,32)
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Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185822
PNG
(US9163003, 36 | USRE46942, Example 36)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2nnnn2C)C1=O
Show InChI InChI=1S/C21H27N7O4/c1-26-21(23-24-25-26)22-18(29)13-28-12-9-17(20(28)31)27-10-7-15(8-11-27)19(30)14-3-5-16(32-2)6-4-14/h3-6,15,17H,7-13H2,1-2H3,(H,22,23,25,29)
PDB

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n/an/a 3.08E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185825
PNG
(US9163003, 16 | USRE46942, Example 17)
Show SMILES COc1ccc2C(=O)C3(Cc2c1)CCN(CC3)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
Show InChI InChI=1S/C26H30N4O5/c1-34-17-2-3-18-16(12-17)13-26(23(18)31)6-9-29(10-7-26)21-4-8-30(25(21)33)14-22-27-20-5-11-35-15-19(20)24(32)28-22/h2-3,12,21H,4-11,13-15H2,1H3,(H,27,28,32)/t21-/m0/s1
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n/an/a 3.85E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185805
PNG
(US9163003, 13 | USRE46942, Example 13)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 4.00E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-2


(Homo sapiens (Human))
BDBM404378
PNG
(N-(isoxazolo[5,4-b]pyridin-3-yl)-2-(3-(4-(4-methox...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2noc3ccccc23)C1=O
Show InChI InChI=1S/C26H28N4O5/c1-34-19-8-6-17(7-9-19)24(32)18-10-13-29(14-11-18)21-12-15-30(26(21)33)16-23(31)27-25-20-4-2-3-5-22(20)35-28-25/h2-9,18,21H,10-16H2,1H3,(H,27,28,31)
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n/an/a 4.56E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185801
PNG
(US9163003, 9 | USRE46942, Example 9)
Show SMILES Clc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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n/an/a 4.62E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185795
PNG
(US9163003, 3 | USRE46942, Example 3)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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n/an/a 4.80E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185820
PNG
(US9163003, 32 | USRE46942, Example 32)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2nnc3SCCn23)C1=O
Show InChI InChI=1S/C23H28N6O4S/c1-33-17-4-2-15(3-5-17)20(31)16-6-9-27(10-7-16)18-8-11-28(21(18)32)14-19(30)24-22-25-26-23-29(22)12-13-34-23/h2-5,16,18H,6-14H2,1H3,(H,24,25,30)
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n/an/a 5.09E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM185804
PNG
(US9163003, 12 | USRE46942, Example 12)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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n/an/a 5.34E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185794
PNG
(US9163003, 2 | USRE46942, Example 2)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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n/an/a 5.40E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185827
PNG
(US9163003, 33 | USRE46942, Example 34)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(CC(=O)Nc2nnc3SCCn23)C1=O
Show InChI InChI=1S/C23H28N6O4S/c1-33-17-4-2-15(3-5-17)20(31)16-6-9-27(10-7-16)18-8-11-28(21(18)32)14-19(30)24-22-25-26-23-29(22)12-13-34-23/h2-5,16,18H,6-14H2,1H3,(H,24,25,30)/t18-/m0/s1
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n/an/a 6.30E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1


(Homo sapiens (Human))
BDBM404378
PNG
(N-(isoxazolo[5,4-b]pyridin-3-yl)-2-(3-(4-(4-methox...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2noc3ccccc23)C1=O
Show InChI InChI=1S/C26H28N4O5/c1-34-19-8-6-17(7-9-19)24(32)18-10-13-29(14-11-18)21-12-15-30(26(21)33)16-23(31)27-25-20-4-2-3-5-22(20)35-28-25/h2-9,18,21H,10-16H2,1H3,(H,27,28,31)
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n/an/a 6.50E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185802
PNG
(US9163003, 10 | USRE46942, Example 10)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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n/an/a 9.20E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185794
PNG
(US9163003, 2 | USRE46942, Example 2)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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n/an/a 9.30E+3n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM404371
PNG
(2-{(R)-3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2cc3ccccc(=O)c3[nH]2)C1=O
PDB

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n/an/a 1.01E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185803
PNG
(US9163003, 11 | USRE46942, Example 11)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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n/an/a 1.02E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185809
PNG
(US9163003, 21 | USRE46942, Example 21)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCCc3c(=O)[nH]2)C1=O
PDB

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n/an/a 1.07E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185801
PNG
(US9163003, 9 | USRE46942, Example 9)
Show SMILES Clc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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n/an/a 1.66E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185814
PNG
(US9163003, 26 | USRE46942, Example 26)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc(C)c(C)c(=O)[nH]2)C1=O
PDB

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n/an/a>1.90E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185812
PNG
(US9163003, 24 | USRE46942, Example 24)
Show SMILES CCc1cc(=O)[nH]c(CN2CCC(N3CCC(CC3)C(=O)c3ccc(OC)cc3)C2=O)n1
PDB

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n/an/a>1.90E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185812
PNG
(US9163003, 24 | USRE46942, Example 24)
Show SMILES CCc1cc(=O)[nH]c(CN2CCC(N3CCC(CC3)C(=O)c3ccc(OC)cc3)C2=O)n1
PDB
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n/an/a>1.90E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185827
PNG
(US9163003, 33 | USRE46942, Example 34)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(CC(=O)Nc2nnc3SCCn23)C1=O
Show InChI InChI=1S/C23H28N6O4S/c1-33-17-4-2-15(3-5-17)20(31)16-6-9-27(10-7-16)18-8-11-28(21(18)32)14-19(30)24-22-25-26-23-29(22)12-13-34-23/h2-5,16,18H,6-14H2,1H3,(H,24,25,30)/t18-/m0/s1
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n/an/a>1.90E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185813
PNG
(US9163003, 25 | USRE46942, Example 25)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2ncc(C)c(=O)[nH]2)C1=O
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n/an/a>1.90E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185798
PNG
(US9163003, 6 | USRE46942, Example 6)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3n(C)ncc3c(=O)[nH]2)C1=O
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Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM404371
PNG
(2-{(R)-3-[4-(4-Methoxy-benzoyl)-piperidin-1-yl]-2-...)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@@H]1CCN(Cc2cc3ccccc(=O)c3[nH]2)C1=O
PDB
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Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 2


(Homo sapiens (Human))
BDBM185798
PNG
(US9163003, 6 | USRE46942, Example 6)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3n(C)ncc3c(=O)[nH]2)C1=O
PDB

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Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185813
PNG
(US9163003, 25 | USRE46942, Example 25)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2ncc(C)c(=O)[nH]2)C1=O
PDB
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n/an/a>1.90E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185820
PNG
(US9163003, 32 | USRE46942, Example 32)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(CC(=O)Nc2nnc3SCCn23)C1=O
Show InChI InChI=1S/C23H28N6O4S/c1-33-17-4-2-15(3-5-17)20(31)16-6-9-27(10-7-16)18-8-11-28(21(18)32)14-19(30)24-22-25-26-23-29(22)12-13-34-23/h2-5,16,18H,6-14H2,1H3,(H,24,25,30)
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n/an/a>1.90E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185814
PNG
(US9163003, 26 | USRE46942, Example 26)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc(C)c(C)c(=O)[nH]2)C1=O
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US Patent
n/an/a>1.90E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185816
PNG
(US9163003, 28 | USRE46942, Example 28)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3ccccc(=O)c3[nH]2)C1=O
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US Patent
n/an/a 2.02E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185795
PNG
(US9163003, 3 | USRE46942, Example 3)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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US Patent
n/an/a 2.10E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185802
PNG
(US9163003, 10 | USRE46942, Example 10)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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US Patent
n/an/a 2.36E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185805
PNG
(US9163003, 13 | USRE46942, Example 13)
Show SMILES COc1ccc(cc1C)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
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US Patent
n/an/a 2.40E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185809
PNG
(US9163003, 21 | USRE46942, Example 21)
Show SMILES COc1ccc(cc1)C(=O)C1CCN(CC1)C1CCN(Cc2nc3CCCc3c(=O)[nH]2)C1=O
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US Patent
n/an/a 2.96E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
Poly [ADP-ribose] polymerase 1


(Homo sapiens (Human))
BDBM185803
PNG
(US9163003, 11 | USRE46942, Example 11)
Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CC1)[C@H]1CCN(Cc2nc3CCOCc3c(=O)[nH]2)C1=O
PDB
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US Patent
n/an/a 3.74E+4n/an/an/an/an/an/a



Novartis AG

US Patent


Assay Description
The human tankyrase 1 PARP catalytic domain, TNKS1P, was cloned into a pDONR221 vector using the Invitrogen Gateway Technology. This entry clone was ...


US Patent USRE46942 (2018)


BindingDB Entry DOI: 10.7270/Q2VX0JVH
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%