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Patent code USRE47267

Compile Data Set for Download or QSAR
Found 31 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM362182
PNG
(USRE47267, Compound 137)
Show SMILES CCOC(=O)c1cc(on1)C(=O)CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H16FN3O5S/c1-2-28-20(27)15-9-17(29-24-15)16(25)11-30-18-8-3-12(10-22-18)19(26)23-14-6-4-13(21)5-7-14/h3-10H,2,11H2,1H3,(H,23,26)
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n/an/a 14n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150812
PNG
(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Show SMILES OB(O)c1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H15BF4N2O4S/c22-14-2-4-15(5-3-14)27-19(28)12-1-8-18(26-10-12)32-11-13-9-16(31-20(23,24)25)6-7-17(13)21(29)30/h1-10,29-30H,11H2,(H,27,28)
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n/an/a 22n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150824
PNG
(US8981106, 14 (SX-585) | USRE47267, Compound 14)
Show SMILES Oc1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H14F4N2O3S/c21-14-2-4-15(5-3-14)26-19(28)12-1-8-18(25-10-12)30-11-13-9-16(6-7-17(13)27)29-20(22,23)24/h1-10,27H,11H2,(H,26,28)
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n/an/a 28n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM362193
PNG
(USRE47267, Compound 168)
Show SMILES OB(O)c1ccccc1COc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H16BFN2O4/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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n/an/a 32n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150975
PNG
(US8981106, 165 | USRE47267, Compound 165)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1O
Show InChI InChI=1S/C19H16BFN2O4S/c21-14-6-7-16(17(24)9-14)23-19(25)12-5-8-18(22-10-12)28-11-13-3-1-2-4-15(13)20(26)27/h1-10,24,26-27H,11H2,(H,23,25)
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n/an/a 37n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150811
PNG
(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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n/an/a 38n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150811
PNG
(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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n/an/a 38n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150811
PNG
(US8981106, 1 (SX-517) | USRE47267, Compound 1)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H16BFN2O3S/c21-15-6-8-16(9-7-15)23-19(24)13-5-10-18(22-11-13)27-12-14-3-1-2-4-17(14)20(25)26/h1-11,25-26H,12H2,(H,23,24)
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n/an/a 38n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150830
PNG
(US8981106, 19 | USRE47267, Compound 19)
Show SMILES CC1(C)OB(OC1(C)C)c1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C26H25BF4N2O4S/c1-24(2)25(3,4)37-27(36-24)21-11-10-20(35-26(29,30)31)13-17(21)15-38-22-12-5-16(14-32-22)23(34)33-19-8-6-18(28)7-9-19/h5-14H,15H2,1-4H3,(H,33,34)
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n/an/a 72n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150966
PNG
(US8981106, 155 | USRE47267, Compound 155)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)N(Cc1ccccn1)c1ccc(F)cc1
Show InChI InChI=1S/C25H21BFN3O3S/c27-20-9-11-22(12-10-20)30(16-21-6-3-4-14-28-21)25(31)18-8-13-24(29-15-18)34-17-19-5-1-2-7-23(19)26(32)33/h1-15,32-33H,16-17H2
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n/an/a 78n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM362183
PNG
(USRE47267, Compound 138)
Show SMILES OC(=O)c1cc(on1)C(=O)CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C18H12FN3O5S/c19-11-2-4-12(5-3-11)21-17(24)10-1-6-16(20-8-10)28-9-14(23)15-7-13(18(25)26)22-27-15/h1-8H,9H2,(H,21,24)(H,25,26)
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n/an/a 81n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM362192
PNG
(USRE47267, Compound 167)
Show SMILES OB(O)c1ccccc1CSc1ncc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C18H15BFN3O3S/c20-14-5-7-15(8-6-14)23-17(24)13-9-21-18(22-10-13)27-11-12-3-1-2-4-16(12)19(25)26/h1-10,25-26H,11H2,(H,23,24)
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n/an/a 116n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM362195
PNG
(USRE47267, Compound 170)
Show SMILES OB(O)c1ccccc1CSc1ncc(cc1Cl)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H15BClFN2O3S/c21-17-9-13(18(25)24-15-7-5-14(22)6-8-15)10-23-19(17)28-11-12-3-1-2-4-16(12)20(26)27/h1-10,26-27H,11H2,(H,24,25)
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n/an/a 166n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150837
PNG
(US8981106, 26 | USRE47267, Compound 26)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3ccccc3-c3nn[nH]n3)nc2)cc1
Show InChI InChI=1S/C20H15FN6OS/c21-15-6-8-16(9-7-15)23-20(28)13-5-10-18(22-11-13)29-12-14-3-1-2-4-17(14)19-24-26-27-25-19/h1-11H,12H2,(H,23,28)(H,24,25,26,27)
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n/an/a 173n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150822
PNG
(US8981106, 13 (SX-578) | USRE47267, Compound 13)
Show SMILES Oc1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H15FN2O2S/c20-15-6-8-16(9-7-15)22-19(24)13-5-10-18(21-11-13)25-12-14-3-1-2-4-17(14)23/h1-11,23H,12H2,(H,22,24)
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n/an/a 277n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150969
PNG
(US8981106, 159 | USRE47267, Compound 159)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(OC(F)(F)F)cc1
Show InChI InChI=1S/C20H16BF3N2O4S/c22-20(23,24)30-16-8-6-15(7-9-16)26-19(27)13-5-10-18(25-11-13)31-12-14-3-1-2-4-17(14)21(28)29/h1-11,28-29H,12H2,(H,26,27)
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Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150824
PNG
(US8981106, 14 (SX-585) | USRE47267, Compound 14)
Show SMILES Oc1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H14F4N2O3S/c21-14-2-4-15(5-3-14)26-19(28)12-1-8-18(25-10-12)30-11-13-9-16(6-7-17(13)27)29-20(22,23)24/h1-10,27H,11H2,(H,26,28)
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n/an/a 1.06E+3n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150915
PNG
(US8981106, 104 | USRE47267, Compound 104)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCC(=O)c3ccc(cc3)-c3nn[nH]n3)nc2)cc1
Show InChI InChI=1S/C21H15FN6O2S/c22-16-6-8-17(9-7-16)24-21(30)15-5-10-19(23-11-15)31-12-18(29)13-1-3-14(4-2-13)20-25-27-28-26-20/h1-11H,12H2,(H,24,30)(H,25,26,27,28)
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n/an/a 1.15E+3n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150968
PNG
(US8981106, 158 | USRE47267, Compound 158)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)N(CC(O)=O)c1ccc(F)cc1
Show InChI InChI=1S/C21H18BFN2O5S/c23-16-6-8-17(9-7-16)25(12-20(26)27)21(28)14-5-10-19(24-11-14)31-13-15-3-1-2-4-18(15)22(29)30/h1-11,29-30H,12-13H2,(H,26,27)
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n/an/a 1.99E+3n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150836
PNG
(US8981106, 25 | USRE47267, Compound 25)
Show SMILES OC(=O)c1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C20H15FN2O3S/c21-16-5-7-17(8-6-16)23-19(24)15-4-9-18(22-11-15)27-12-13-2-1-3-14(10-13)20(25)26/h1-11H,12H2,(H,23,24)(H,25,26)
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n/an/a 2.12E+3n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM362194
PNG
(USRE47267, Compound 169)
Show SMILES Fc1ccc(NC(=O)c2ccc(OCc3ccccc3)nc2)cc1
Show InChI InChI=1S/C19H15FN2O2/c20-16-7-9-17(10-8-16)22-19(23)15-6-11-18(21-12-15)24-13-14-4-2-1-3-5-14/h1-12H,13H2,(H,22,23)
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n/an/a 3.10E+3n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150860
PNG
(US8981106, 49 | USRE47267, Compound 49)
Show SMILES Fc1ccc(NC(=O)c2ccc(SCc3nn[nH]n3)nc2)cc1
Show InChI InChI=1S/C14H11FN6OS/c15-10-2-4-11(5-3-10)17-14(22)9-1-6-13(16-7-9)23-8-12-18-20-21-19-12/h1-7H,8H2,(H,17,22)(H,18,19,20,21)
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n/an/a 3.90E+3n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150965
PNG
(US8981106, 154 | USRE47267, Compound 154)
Show SMILES CN(C(=O)c1ccc(SCc2ccccc2B(O)O)nc1)c1ccc(F)cc1
Show InChI InChI=1S/C20H18BFN2O3S/c1-24(17-9-7-16(22)8-10-17)20(25)14-6-11-19(23-12-14)28-13-15-4-2-3-5-18(15)21(26)27/h2-12,26-27H,13H2,1H3
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n/an/a>5.00E+3n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150823
PNG
(US8981106, 13a | USRE47267, Compound 13a)
Show SMILES CC(=O)Oc1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C21H17FN2O3S/c1-14(25)27-19-5-3-2-4-16(19)13-28-20-11-6-15(12-23-20)21(26)24-18-9-7-17(22)8-10-18/h2-12H,13H2,1H3,(H,24,26)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150833
PNG
(US8981106, 22 | USRE47267, Compound 22)
Show SMILES COC(=O)c1cccc(CSc2ccc(cn2)C(=O)Nc2ccc(F)cc2)c1
Show InChI InChI=1S/C21H17FN2O3S/c1-27-21(26)15-4-2-3-14(11-15)13-28-19-10-5-16(12-23-19)20(25)24-18-8-6-17(22)7-9-18/h2-12H,13H2,1H3,(H,24,25)
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n/an/a>5.00E+3n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150970
PNG
(US8981106, 160 | USRE47267, Compound 160)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(cc1)C(O)=O
Show InChI InChI=1S/C20H17BN2O5S/c24-19(23-16-8-5-13(6-9-16)20(25)26)14-7-10-18(22-11-14)29-12-15-3-1-2-4-17(15)21(27)28/h1-11,27-28H,12H2,(H,23,24)(H,25,26)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150976
PNG
(US8981106, 166 | USRE47267, Compound 166)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)c(c1)C(O)=O
Show InChI InChI=1S/C20H16BFN2O5S/c22-17-7-6-14(9-15(17)20(26)27)24-19(25)12-5-8-18(23-10-12)30-11-13-3-1-2-4-16(13)21(28)29/h1-10,28-29H,11H2,(H,24,25)(H,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150971
PNG
(US8981106, 161 | USRE47267, Compound 161)
Show SMILES OB(O)c1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(cc1)-c1nn[nH]n1
Show InChI InChI=1S/C20H17BN6O3S/c28-20(23-16-8-5-13(6-9-16)19-24-26-27-25-19)14-7-10-18(22-11-14)31-12-15-3-1-2-4-17(15)21(29)30/h1-11,29-30H,12H2,(H,23,28)(H,24,25,26,27)
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n/an/a>1.00E+4n/an/an/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150824
PNG
(US8981106, 14 (SX-585) | USRE47267, Compound 14)
Show SMILES Oc1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H14F4N2O3S/c21-14-2-4-15(5-3-14)26-19(28)12-1-8-18(25-10-12)30-11-13-9-16(6-7-17(13)27)29-20(22,23)24/h1-10,27H,11H2,(H,26,28)
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n/an/an/an/a 1.81E+3n/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150812
PNG
(US8981106, 2 (SX-576) | USRE47267, Compound 2)
Show SMILES OB(O)c1ccc(OC(F)(F)F)cc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C20H15BF4N2O4S/c22-14-2-4-15(5-3-14)27-19(28)12-1-8-18(26-10-12)32-11-13-9-16(31-20(23,24)25)6-7-17(13)21(29)30/h1-10,29-30H,11H2,(H,27,28)
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n/an/an/an/a 1.25E+3n/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
Interleukin-8 receptors, CXCR1/CXCR2


(Homo sapiens (Human))
BDBM150822
PNG
(US8981106, 13 (SX-578) | USRE47267, Compound 13)
Show SMILES Oc1ccccc1CSc1ccc(cn1)C(=O)Nc1ccc(F)cc1
Show InChI InChI=1S/C19H15FN2O2S/c20-15-6-8-16(9-7-15)22-19(24)13-5-10-18(21-11-13)25-12-14-3-1-2-4-17(14)23/h1-11,23H,12H2,(H,22,24)
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n/an/an/an/a 2.40E+3n/an/an/an/a



Syntrix Biosystems, Inc.

US Patent


Assay Description
The assay is a Ca2+ mobilization assay that measures changes in intracellular Ca2+ with a FlexStation II scanning fluorometer using a FLIPR-3 Calcium...


US Patent USRE47267 (2019)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%