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Patent code USRE48059

Compile Data Set for Download or QSAR
Found 122 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194790
PNG
(US9206167, 11 | US9206167, 12 | USRE48059, Compoun...)
Show SMILES O=C1CCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2N1
Show InChI InChI=1S/C25H29N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-6,8,10,17-18H,1-2,7,9,11-16H2,(H,26,29)
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0.100n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194790
PNG
(US9206167, 11 | US9206167, 12 | USRE48059, Compoun...)
Show SMILES O=C1CCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2N1
Show InChI InChI=1S/C25H29N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-6,8,10,17-18H,1-2,7,9,11-16H2,(H,26,29)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194780
PNG
(7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butox...)
Show SMILES O=c1ccc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2[nH]1
Show InChI InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-10,17-18H,1-2,11-16H2,(H,26,29)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194794
PNG
(US9206167, 15 | USRE48059, Compound of Example 15)
Show SMILES O=C1CCc2ccc(OC\C=C\CN3CCN(CC3)c3cccc4sccc34)cc2N1
Show InChI InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h1-6,8,10,17-18H,7,9,11-16H2,(H,26,29)/b2-1+
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448338
PNG
(USRE48059, Compound of Example 139)
Show SMILES OCc1cc2CCC(=C)Nc2cc1CCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C26H31N3OS/c1-19-7-8-21-16-22(18-30)20(17-24(21)27-19)4-3-10-28-11-13-29(14-12-28)25-5-2-6-26-23(25)9-15-31-26/h2,5-6,9,15-17,27,30H,1,3-4,7-8,10-14,18H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448330
PNG
(USRE48059, Compound of Example 90)
Show SMILES CC(=O)N1CCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2C1
Show InChI InChI=1S/C27H33N3O2S/c1-21(31)30-12-9-22-7-8-24(19-23(22)20-30)32-17-3-2-11-28-13-15-29(16-14-28)26-5-4-6-27-25(26)10-18-33-27/h4-8,10,18-19H,2-3,9,11-17,20H2,1H3
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194789
PNG
(US9206167, 10 | USRE48059, Compound of Example 10)
Show SMILES O=C1CCc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2N1
Show InChI InChI=1S/C24H27N3O2S/c28-24-8-6-18-5-7-19(17-21(18)25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-20(22)9-16-30-23/h1,3-5,7,9,16-17H,2,6,8,10-15H2,(H,25,28)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194782
PNG
(US9206167, 3 | USRE48059, Compound of Example 3)
Show SMILES Cc1cc(=O)[nH]c2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc12
Show InChI InChI=1S/C25H27N3O2S/c1-18-16-25(29)26-22-17-19(6-7-20(18)22)30-14-3-9-27-10-12-28(13-11-27)23-4-2-5-24-21(23)8-15-31-24/h2,4-8,15-17H,3,9-14H2,1H3,(H,26,29)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194783
PNG
(US9206167, 4 | USRE48059, Compound of Example 4)
Show SMILES Cc1cc(=O)[nH]c2cc(OCCCCN3CCN(CC3)c3cccc4sccc34)ccc12
Show InChI InChI=1S/C26H29N3O2S/c1-19-17-26(30)27-23-18-20(7-8-21(19)23)31-15-3-2-10-28-11-13-29(14-12-28)24-5-4-6-25-22(24)9-16-32-25/h4-9,16-18H,2-3,10-15H2,1H3,(H,27,30)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194786
PNG
(US9206167, 7 | USRE48059, Compound of Example 7)
Show SMILES O=c1ccc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2[nH]1
Show InChI InChI=1S/C24H25N3O2S/c28-24-8-6-18-5-7-19(17-21(18)25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-20(22)9-16-30-23/h1,3-9,16-17H,2,10-15H2,(H,25,28)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194784
PNG
(US9206167, 5 | USRE48059, Compound of Example 5)
Show SMILES Cc1cc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2[nH]c1=O
Show InChI InChI=1S/C25H27N3O2S/c1-18-16-19-6-7-20(17-22(19)26-25(18)29)30-14-3-9-27-10-12-28(13-11-27)23-4-2-5-24-21(23)8-15-31-24/h2,4-8,15-17H,3,9-14H2,1H3,(H,26,29)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194787
PNG
(US9206167, 8 | USRE48059, Compound of Example 8)
Show SMILES O=c1ccc2ccccc2n1CCCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C25H27N3OS/c29-25-11-10-20-6-1-2-7-22(20)28(25)14-4-3-13-26-15-17-27(18-16-26)23-8-5-9-24-21(23)12-19-30-24/h1-2,5-12,19H,3-4,13-18H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194808
PNG
(US10501452, Compound B | US9206167, 30 | USRE48059...)
Show SMILES CN1CCc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2C1=O
Show InChI InChI=1S/C25H29N3O2S/c1-26-11-8-19-6-7-20(18-22(19)25(26)29)30-16-3-10-27-12-14-28(15-13-27)23-4-2-5-24-21(23)9-17-31-24/h2,4-7,9,17-18H,3,8,10-16H2,1H3
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194795
PNG
(US9206167, 16 | USRE48059, Compound of Example 16)
Show SMILES CC1CC(=O)Nc2cc(OCCCCN3CCN(CC3)c3cccc4sccc34)ccc12
Show InChI InChI=1S/C26H31N3O2S/c1-19-17-26(30)27-23-18-20(7-8-21(19)23)31-15-3-2-10-28-11-13-29(14-12-28)24-5-4-6-25-22(24)9-16-32-25/h4-9,16,18-19H,2-3,10-15,17H2,1H3,(H,27,30)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194802
PNG
(US9206167, 23 | USRE48059, Compound of Example 23)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2cccc3sccc23)CCc2ccccc12
Show InChI InChI=1S/C25H29N3OS/c29-25-21-7-2-1-6-20(21)10-14-28(25)13-4-3-12-26-15-17-27(18-16-26)23-8-5-9-24-22(23)11-19-30-24/h1-2,5-9,11,19H,3-4,10,12-18H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448346
PNG
(USRE48059, Compound of Example 190)
Show SMILES Oc1ccc(CCCCN2CCN(CC2)c2cccc3sccc23)c2NC(=O)CCc12
Show InChI InChI=1S/C25H29N3O2S/c29-22-9-7-18(25-20(22)8-10-24(30)26-25)4-1-2-12-27-13-15-28(16-14-27)21-5-3-6-23-19(21)11-17-31-23/h3,5-7,9,11,17,29H,1-2,4,8,10,12-16H2,(H,26,30)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194785
PNG
(US9206167, 6 | USRE48059, Compound of Example 6)
Show SMILES Cc1cc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2[nH]c1=O
Show InChI InChI=1S/C26H29N3O2S/c1-19-17-20-7-8-21(18-23(20)27-26(19)30)31-15-3-2-10-28-11-13-29(14-12-28)24-5-4-6-25-22(24)9-16-32-25/h4-9,16-18H,2-3,10-15H2,1H3,(H,27,30)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448323
PNG
(USRE48059, Compound of Example 69)
Show SMILES CC1CN(CCN1CCCCOc1ccc2[nH]c(=O)ccc2c1)c1cccc2sccc12
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448327
PNG
(USRE48059, Compound of Example 81)
Show SMILES CC(=C)n1ccc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc2c1
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194814
PNG
(US9206167, 36 | USRE48059, Compound of Example 36)
Show SMILES Cn1ccc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2c1=O
Show InChI InChI=1S/C25H27N3O2S/c1-26-11-8-19-6-7-20(18-22(19)25(26)29)30-16-3-10-27-12-14-28(15-13-27)23-4-2-5-24-21(23)9-17-31-24/h2,4-9,11,17-18H,3,10,12-16H2,1H3
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448322
PNG
(USRE48059, Compound of Example 68)
Show SMILES CC1CN(CCN1CCCCOc1ccc2nc(=O)ccc2c1)c1cccc2sccc12
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194800
PNG
(US9206167, 21 | USRE48059, Compound of Example 21)
Show SMILES O=C1CCc2ccccc2N1CCCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C25H29N3OS/c29-25-11-10-20-6-1-2-7-22(20)28(25)14-4-3-13-26-15-17-27(18-16-26)23-8-5-9-24-21(23)12-19-30-24/h1-2,5-9,12,19H,3-4,10-11,13-18H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194811
PNG
(US9206167, 33 | USRE48059, Compound of Example 33)
Show SMILES O=C1NCCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc12
Show InChI InChI=1S/C25H29N3O2S/c29-25-22-18-20(7-6-19(22)8-10-26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)9-17-31-24/h3-7,9,17-18H,1-2,8,10-16H2,(H,26,29)
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1.10n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194798
PNG
(US9206167, 19 | USRE48059, Compound of Example 19)
Show SMILES O=C1CCc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc2N1
Show InChI InChI=1S/C24H27N3O2S/c28-24-8-5-18-17-19(6-7-21(18)25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-20(22)9-16-30-23/h1,3-4,6-7,9,16-17H,2,5,8,10-15H2,(H,25,28)
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1.20n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194798
PNG
(US9206167, 19 | USRE48059, Compound of Example 19)
Show SMILES O=C1CCc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc2N1
Show InChI InChI=1S/C24H27N3O2S/c28-24-8-5-18-17-19(6-7-21(18)25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-20(22)9-16-30-23/h1,3-4,6-7,9,16-17H,2,5,8,10-15H2,(H,25,28)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194812
PNG
(US9206167, 34 | USRE48059, Compound of Example 34)
Show SMILES O=c1n(CCCCN2CCN(CC2)c2cccc3sccc23)ccc2ccccc12
Show InChI InChI=1S/C25H27N3OS/c29-25-21-7-2-1-6-20(21)10-14-28(25)13-4-3-12-26-15-17-27(18-16-26)23-8-5-9-24-22(23)11-19-30-24/h1-2,5-11,14,19H,3-4,12-13,15-18H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194816
PNG
(US9206167, 38 | USRE48059, Compound of Example 38)
Show SMILES COc1ccc2ccn(CCCCN3CCN(CC3)c3cccc4sccc34)c(=O)c2c1
Show InChI InChI=1S/C26H29N3O2S/c1-31-21-8-7-20-9-13-29(26(30)23(20)19-21)12-3-2-11-27-14-16-28(17-15-27)24-5-4-6-25-22(24)10-18-32-25/h4-10,13,18-19H,2-3,11-12,14-17H2,1H3
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194817
PNG
(US9206167, 39 | USRE48059, Compound of Example 39)
Show SMILES Oc1ccc2ccn(CCCCN3CCN(CC3)c3cccc4sccc34)c(=O)c2c1
Show InChI InChI=1S/C25H27N3O2S/c29-20-7-6-19-8-12-28(25(30)22(19)18-20)11-2-1-10-26-13-15-27(16-14-26)23-4-3-5-24-21(23)9-17-31-24/h3-9,12,17-18,29H,1-2,10-11,13-16H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194807
PNG
(US10501452, Compound C | US9206167, 28 | USRE48059...)
Show SMILES O=C1NCCc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc12
Show InChI InChI=1S/C24H27N3O2S/c28-24-21-17-19(6-5-18(21)7-9-25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-20(22)8-16-30-23/h1,3-6,8,16-17H,2,7,9-15H2,(H,25,28)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448337
PNG
(USRE48059, Compound of Example 128)
Show SMILES CC(=O)Oc1ccc(CCCN2CCN(CC2)c2cccc3sccc23)c2NC(=O)CCc12
Show InChI InChI=1S/C26H29N3O3S/c1-18(30)32-23-9-7-19(26-21(23)8-10-25(31)27-26)4-3-12-28-13-15-29(16-14-28)22-5-2-6-24-20(22)11-17-33-24/h2,5-7,9,11,17H,3-4,8,10,12-16H2,1H3,(H,27,31)
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1.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448334
PNG
(USRE48059, Compound of Example 117)
Show SMILES Cc1cccc2cc(OCCCCN3CCN(CC3)c3cccc4sccc34)c(=O)nc12
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448324
PNG
(USRE48059, Compound of Example 73 | USRE48059, Com...)
Show SMILES C(COc1ccc2ncccc2c1)CN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C24H25N3OS/c1-5-23(21-9-17-29-24(21)6-1)27-14-12-26(13-15-27)11-3-16-28-20-7-8-22-19(18-20)4-2-10-25-22/h1-2,4-10,17-18H,3,11-16H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448331
PNG
(USRE48059, Compound of Example 91)
Show SMILES Fc1cc2CCNC(=O)c2cc1OCCCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C25H28FN3O2S/c26-21-16-18-6-8-27-25(30)20(18)17-23(21)31-14-2-1-9-28-10-12-29(13-11-28)22-4-3-5-24-19(22)7-15-32-24/h3-5,7,15-17H,1-2,6,8-14H2,(H,27,30)
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1.40n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194809
PNG
(US9206167, 31 | USRE48059, Compound of Example 31)
Show SMILES CCN1CCc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2C1=O
Show InChI InChI=1S/C26H31N3O2S/c1-2-28-12-9-20-7-8-21(19-23(20)26(28)30)31-17-4-11-27-13-15-29(16-14-27)24-5-3-6-25-22(24)10-18-32-25/h3,5-8,10,18-19H,2,4,9,11-17H2,1H3
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194812
PNG
(US9206167, 34 | USRE48059, Compound of Example 34)
Show SMILES O=c1n(CCCCN2CCN(CC2)c2cccc3sccc23)ccc2ccccc12
Show InChI InChI=1S/C25H27N3OS/c29-25-21-7-2-1-6-20(21)10-14-28(25)13-4-3-12-26-15-17-27(18-16-26)23-8-5-9-24-22(23)11-19-30-24/h1-2,5-11,14,19H,3-4,12-13,15-18H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194810
PNG
(US9206167, 32 | USRE48059, Compound of Example 32)
Show SMILES CN1CCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2C1=O
Show InChI InChI=1S/C26H31N3O2S/c1-27-12-9-20-7-8-21(19-23(20)26(27)30)31-17-3-2-11-28-13-15-29(16-14-28)24-5-4-6-25-22(24)10-18-32-25/h4-8,10,18-19H,2-3,9,11-17H2,1H3
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194781
PNG
(US9206167, 2 | USRE48059, Compound of Example 2)
Show SMILES O=c1[nH]c2ccccc2cc1OCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C23H23N3O2S/c27-23-21(16-17-4-1-2-5-19(17)24-23)28-14-13-25-9-11-26(12-10-25)20-6-3-7-22-18(20)8-15-29-22/h1-8,15-16H,9-14H2,(H,24,27)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194799
PNG
(US9206167, 20 | USRE48059, Compound of Example 20)
Show SMILES O=C1CCc2cc(OCCCCN3CCN(CC3)c3cccc4sccc34)ccc2N1
Show InChI InChI=1S/C25H29N3O2S/c29-25-9-6-19-18-20(7-8-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-5,7-8,10,17-18H,1-2,6,9,11-16H2,(H,26,29)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448326
PNG
(USRE48059, Compound of Example 80)
Show SMILES C(COc1ccc2cnccc2c1)CN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C24H25N3OS/c1-3-23(22-8-16-29-24(22)4-1)27-13-11-26(12-14-27)10-2-15-28-21-6-5-20-18-25-9-7-19(20)17-21/h1,3-9,16-18H,2,10-15H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194813
PNG
(US9206167, 35 | USRE48059, Compound of Example 35)
Show SMILES O=c1[nH]ccc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc12
Show InChI InChI=1S/C24H25N3O2S/c28-24-21-17-19(6-5-18(21)7-9-25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-20(22)8-16-30-23/h1,3-9,16-17H,2,10-15H2,(H,25,28)
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1.60n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448345
PNG
(USRE48059, Compound of Example 188)
Show SMILES O=c1ccc2c(CCCN3CCN(CC3)c3cccc4sccc34)cccc2[nH]1
Show InChI InChI=1S/C24H25N3OS/c28-24-10-9-19-18(4-1-6-21(19)25-24)5-3-12-26-13-15-27(16-14-26)22-7-2-8-23-20(22)11-17-29-23/h1-2,4,6-11,17H,3,5,12-16H2,(H,25,28)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448332
PNG
(USRE48059, Compound of Example 92)
Show SMILES CN1CCc2cc(F)c(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2C1=O
Show InChI InChI=1S/C26H30FN3O2S/c1-28-10-7-19-17-22(27)24(18-21(19)26(28)31)32-15-3-2-9-29-11-13-30(14-12-29)23-5-4-6-25-20(23)8-16-33-25/h4-6,8,16-18H,2-3,7,9-15H2,1H3
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1.70n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194802
PNG
(US9206167, 23 | USRE48059, Compound of Example 23)
Show SMILES O=C1N(CCCCN2CCN(CC2)c2cccc3sccc23)CCc2ccccc12
Show InChI InChI=1S/C25H29N3OS/c29-25-21-7-2-1-6-20(21)10-14-28(25)13-4-3-12-26-15-17-27(18-16-26)23-8-5-9-24-22(23)11-19-30-24/h1-2,5-9,11,19H,3-4,10,12-18H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194819
PNG
(US9206167, 41 | USRE48059, Compound of Example 41)
Show SMILES Cn1ccc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc2c1=O
Show InChI InChI=1S/C25H27N3O2S/c1-26-11-8-19-18-20(6-7-21(19)25(26)29)30-16-3-10-27-12-14-28(15-13-27)23-4-2-5-24-22(23)9-17-31-24/h2,4-9,11,17-18H,3,10,12-16H2,1H3
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1.90n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194815
PNG
(US9206167, 37 | USRE48059, Compound of Example 37)
Show SMILES CCn1ccc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2c1=O
Show InChI InChI=1S/C26H29N3O2S/c1-2-28-12-9-20-7-8-21(19-23(20)26(28)30)31-17-4-11-27-13-15-29(16-14-27)24-5-3-6-25-22(24)10-18-32-25/h3,5-10,12,18-19H,2,4,11,13-17H2,1H3
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1.90n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194808
PNG
(US10501452, Compound B | US9206167, 30 | USRE48059...)
Show SMILES CN1CCc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2C1=O
Show InChI InChI=1S/C25H29N3O2S/c1-26-11-8-19-6-7-20(18-22(19)25(26)29)30-16-3-10-27-12-14-28(15-13-27)23-4-2-5-24-21(23)9-17-31-24/h2,4-7,9,17-18H,3,8,10-16H2,1H3
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2n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448329
PNG
(USRE48059, Compound of Example 85)
Show SMILES C(CCN1CCN(CC1)c1cccc2sccc12)COc1ccc2ncccc2c1
Show InChI InChI=1S/C25H27N3OS/c1(2-17-29-21-8-9-23-20(19-21)5-4-11-26-23)12-27-13-15-28(16-14-27)24-6-3-7-25-22(24)10-18-30-25/h3-11,18-19H,1-2,12-17H2
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2n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194790
PNG
(US9206167, 11 | US9206167, 12 | USRE48059, Compoun...)
Show SMILES O=C1CCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2N1
Show InChI InChI=1S/C25H29N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-6,8,10,17-18H,1-2,7,9,11-16H2,(H,26,29)
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2.10n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194817
PNG
(US9206167, 39 | USRE48059, Compound of Example 39)
Show SMILES Oc1ccc2ccn(CCCCN3CCN(CC3)c3cccc4sccc34)c(=O)c2c1
Show InChI InChI=1S/C25H27N3O2S/c29-20-7-6-19-8-12-28(25(30)22(19)18-20)11-2-1-10-26-13-15-27(16-14-26)23-4-3-5-24-21(23)9-17-31-24/h3-9,12,17-18,29H,1-2,10-11,13-16H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194814
PNG
(US9206167, 36 | USRE48059, Compound of Example 36)
Show SMILES Cn1ccc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2c1=O
Show InChI InChI=1S/C25H27N3O2S/c1-26-11-8-19-6-7-20(18-22(19)25(26)29)30-16-3-10-27-12-14-28(15-13-27)23-4-2-5-24-21(23)9-17-31-24/h2,4-9,11,17-18H,3,10,12-16H2,1H3
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194813
PNG
(US9206167, 35 | USRE48059, Compound of Example 35)
Show SMILES O=c1[nH]ccc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc12
Show InChI InChI=1S/C24H25N3O2S/c28-24-21-17-19(6-5-18(21)7-9-25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-20(22)8-16-30-23/h1,3-9,16-17H,2,10-15H2,(H,25,28)
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194796
PNG
(US9206167, 17 | USRE48059, Compound of Example 17)
Show SMILES O=C1CCc2ccc(OCCOCCN3CCN(CC3)c3cccc4sccc34)cc2N1
Show InChI InChI=1S/C25H29N3O3S/c29-25-7-5-19-4-6-20(18-22(19)26-25)31-16-15-30-14-13-27-9-11-28(12-10-27)23-2-1-3-24-21(23)8-17-32-24/h1-4,6,8,17-18H,5,7,9-16H2,(H,26,29)
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2.20n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448344
PNG
(USRE48059, Compound of Example 186)
Show SMILES O=C1CCc2cccc(CCCN3CCN(CC3)c3cccc4sccc34)c2N1
Show InChI InChI=1S/C24H27N3OS/c28-23-10-9-19-5-1-4-18(24(19)25-23)6-3-12-26-13-15-27(16-14-26)21-7-2-8-22-20(21)11-17-29-22/h1-2,4-5,7-8,11,17H,3,6,9-10,12-16H2,(H,25,28)
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2.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194780
PNG
(7-(4-(4-(1-benzothiophen-4-yl)piperazin-1-yl)butox...)
Show SMILES O=c1ccc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2[nH]1
Show InChI InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-10,17-18H,1-2,11-16H2,(H,26,29)
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2.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194782
PNG
(US9206167, 3 | USRE48059, Compound of Example 3)
Show SMILES Cc1cc(=O)[nH]c2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc12
Show InChI InChI=1S/C25H27N3O2S/c1-18-16-25(29)26-22-17-19(6-7-20(18)22)30-14-3-9-27-10-12-28(13-11-27)23-4-2-5-24-21(23)8-15-31-24/h2,4-8,15-17H,3,9-14H2,1H3,(H,26,29)
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2.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194803
PNG
(US9206167, 24 | USRE48059, Compound of Example 24)
Show SMILES O=C1N(CCCCCN2CCN(CC2)c2cccc3sccc23)CCc2ccccc12
Show InChI InChI=1S/C26H31N3OS/c30-26-22-8-3-2-7-21(22)11-15-29(26)14-5-1-4-13-27-16-18-28(19-17-27)24-9-6-10-25-23(24)12-20-31-25/h2-3,6-10,12,20H,1,4-5,11,13-19H2
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448339
PNG
(USRE48059, Compound of Example 155)
Show SMILES CC(=O)Nc1ccc(CCCN2CCN(CC2)c2cccc3sccc23)c2CCC(=O)Nc12
Show InChI InChI=1S/C26H30N4O2S/c1-18(31)27-22-9-7-19(20-8-10-25(32)28-26(20)22)4-3-12-29-13-15-30(16-14-29)23-5-2-6-24-21(23)11-17-33-24/h2,5-7,9,11,17H,3-4,8,10,12-16H2,1H3,(H,27,31)(H,28,32)
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2.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448324
PNG
(USRE48059, Compound of Example 73 | USRE48059, Com...)
Show SMILES C(COc1ccc2ncccc2c1)CN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C24H25N3OS/c1-5-23(21-9-17-29-24(21)6-1)27-14-12-26(13-15-27)11-3-16-28-20-7-8-22-19(18-20)4-2-10-25-22/h1-2,4-10,17-18H,3,11-16H2
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2.40n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194792
PNG
(US9206167, 13 | USRE48059, Compound of Example 13)
Show SMILES O=C1CCc2ccc(OC\C=C/CN3CCN(CC3)c3cccc4sccc34)cc2N1
Show InChI InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h1-6,8,10,17-18H,7,9,11-16H2,(H,26,29)/b2-1-
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Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448326
PNG
(USRE48059, Compound of Example 80)
Show SMILES C(COc1ccc2cnccc2c1)CN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C24H25N3OS/c1-3-23(22-8-16-29-24(22)4-1)27-13-11-26(12-14-27)10-2-15-28-21-6-5-20-18-25-9-7-19(20)17-21/h1,3-9,16-18H,2,10-15H2
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2.5n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194797
PNG
(US9206167, 18 | USRE48059, Compound of Example 18)
Show SMILES CN1C(=O)CCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc12
Show InChI InChI=1S/C26H31N3O2S/c1-27-24-19-21(9-7-20(24)8-10-26(27)30)31-17-3-2-12-28-13-15-29(16-14-28)23-5-4-6-25-22(23)11-18-32-25/h4-7,9,11,18-19H,2-3,8,10,12-17H2,1H3
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2.60n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448327
PNG
(USRE48059, Compound of Example 81)
Show SMILES CC(=C)n1ccc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc2c1
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2.60n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194788
PNG
(US9206167, 9 | USRE48059, Compound of Example 9)
Show SMILES O=c1ccc2ccccc2n1CCCCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C26H29N3OS/c30-26-12-11-21-7-2-3-8-23(21)29(26)15-5-1-4-14-27-16-18-28(19-17-27)24-9-6-10-25-22(24)13-20-31-25/h2-3,6-13,20H,1,4-5,14-19H2
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2.60n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448342
PNG
(USRE48059, Compound of Example 184)
Show SMILES Fc1cc(CCCN2CCN(CC2)c2cccc3sccc23)cc2CCC(=O)Nc12
Show InChI InChI=1S/C24H26FN3OS/c25-20-16-17(15-18-6-7-23(29)26-24(18)20)3-2-9-27-10-12-28(13-11-27)21-4-1-5-22-19(21)8-14-30-22/h1,4-5,8,14-16H,2-3,6-7,9-13H2,(H,26,29)
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2.60n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448343
PNG
(USRE48059, Compound of Example 185)
Show SMILES Cc1cc(=O)[nH]c2cccc(CCCN3CCN(CC3)c3cccc4sccc34)c12
Show InChI InChI=1S/C25H27N3OS/c1-18-17-24(29)26-21-7-2-5-19(25(18)21)6-4-11-27-12-14-28(15-13-27)22-8-3-9-23-20(22)10-16-30-23/h2-3,5,7-10,16-17H,4,6,11-15H2,1H3,(H,26,29)
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2.70n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194807
PNG
(US10501452, Compound C | US9206167, 28 | USRE48059...)
Show SMILES O=C1NCCc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc12
Show InChI InChI=1S/C24H27N3O2S/c28-24-21-17-19(6-5-18(21)7-9-25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-20(22)8-16-30-23/h1,3-6,8,16-17H,2,7,9-15H2,(H,25,28)
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2.80n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448341
PNG
(USRE48059, Compound of Example 163)
Show SMILES Clc1cc2CCC(=C)Nc2c(Cl)c1CCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C25H27Cl2N3S/c1-17-7-8-18-16-21(26)19(24(27)25(18)28-17)4-3-10-29-11-13-30(14-12-29)22-5-2-6-23-20(22)9-15-31-23/h2,5-6,9,15-16,28H,1,3-4,7-8,10-14H2
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2.80n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194796
PNG
(US9206167, 17 | USRE48059, Compound of Example 17)
Show SMILES O=C1CCc2ccc(OCCOCCN3CCN(CC3)c3cccc4sccc34)cc2N1
Show InChI InChI=1S/C25H29N3O3S/c29-25-7-5-19-4-6-20(18-22(19)26-25)31-16-15-30-14-13-27-9-11-28(12-10-27)23-2-1-3-24-21(23)8-17-32-24/h1-4,6,8,17-18H,5,7,9-16H2,(H,26,29)
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2.80n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448336
PNG
(USRE48059, Compound of Example 122)
Show SMILES O=C1CCc2c(CCCN3CCN(CC3)c3cccc4sccc34)cccc2N1
Show InChI InChI=1S/C24H27N3OS/c28-24-10-9-19-18(4-1-6-21(19)25-24)5-3-12-26-13-15-27(16-14-26)22-7-2-8-23-20(22)11-17-29-23/h1-2,4,6-8,11,17H,3,5,9-10,12-16H2,(H,25,28)
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2.90n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194801
PNG
(US9206167, 22 | USRE48059, Compound of Example 22)
Show SMILES O=C1CCc2ccccc2N1CCCCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C26H31N3OS/c30-26-12-11-21-7-2-3-8-23(21)29(26)15-5-1-4-14-27-16-18-28(19-17-27)24-9-6-10-25-22(24)13-20-31-25/h2-3,6-10,13,20H,1,4-5,11-12,14-19H2
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2.90n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448346
PNG
(USRE48059, Compound of Example 190)
Show SMILES Oc1ccc(CCCCN2CCN(CC2)c2cccc3sccc23)c2NC(=O)CCc12
Show InChI InChI=1S/C25H29N3O2S/c29-22-9-7-18(25-20(22)8-10-24(30)26-25)4-1-2-12-27-13-15-28(16-14-27)21-5-3-6-23-19(21)11-17-31-23/h3,5-7,9,11,17,29H,1-2,4,8,10,12-16H2,(H,26,30)
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2.90n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194789
PNG
(US9206167, 10 | USRE48059, Compound of Example 10)
Show SMILES O=C1CCc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2N1
Show InChI InChI=1S/C24H27N3O2S/c28-24-8-6-18-5-7-19(17-21(18)25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-20(22)9-16-30-23/h1,3-5,7,9,16-17H,2,6,8,10-15H2,(H,25,28)
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3n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448339
PNG
(USRE48059, Compound of Example 155)
Show SMILES CC(=O)Nc1ccc(CCCN2CCN(CC2)c2cccc3sccc23)c2CCC(=O)Nc12
Show InChI InChI=1S/C26H30N4O2S/c1-18(31)27-22-9-7-19(20-8-10-25(32)28-26(20)22)4-3-12-29-13-15-30(16-14-29)23-5-2-6-24-21(23)11-17-33-24/h2,5-7,9,11,17H,3-4,8,10,12-16H2,1H3,(H,27,31)(H,28,32)
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3n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194815
PNG
(US9206167, 37 | USRE48059, Compound of Example 37)
Show SMILES CCn1ccc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2c1=O
Show InChI InChI=1S/C26H29N3O2S/c1-2-28-12-9-20-7-8-21(19-23(20)26(28)30)31-17-4-11-27-13-15-29(16-14-27)24-5-3-6-25-22(24)10-18-32-25/h3,5-10,12,18-19H,2,4,11,13-17H2,1H3
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3.10n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448352
PNG
(USRE48059, Compound of Example 89)
Show SMILES C(CCN1CCN(CC1)c1cccc2sccc12)COc1ccc2CCNCc2c1
Show InChI InChI=1S/C25H31N3OS/c1(2-16-29-22-7-6-20-8-10-26-19-21(20)18-22)11-27-12-14-28(15-13-27)24-4-3-5-25-23(24)9-17-30-25/h3-7,9,17-18,26H,1-2,8,10-16,19H2
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3.10n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448321
PNG
(USRE48059, Compound of Example 64)
Show SMILES CC1CN(CCN1CCCOc1ccc2nc(=O)ccc2c1)c1cccc2sccc12
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3.20n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194793
PNG
(US9206167, 14 | USRE48059, Compound of Example 14)
Show SMILES CC(CCOc1ccc2CCC(=O)Nc2c1)CN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C26H31N3O2S/c1-19(9-15-31-21-7-5-20-6-8-26(30)27-23(20)17-21)18-28-11-13-29(14-12-28)24-3-2-4-25-22(24)10-16-32-25/h2-5,7,10,16-17,19H,6,8-9,11-15,18H2,1H3,(H,27,30)
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3.20n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194819
PNG
(US9206167, 41 | USRE48059, Compound of Example 41)
Show SMILES Cn1ccc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc2c1=O
Show InChI InChI=1S/C25H27N3O2S/c1-26-11-8-19-18-20(6-7-21(19)25(26)29)30-16-3-10-27-12-14-28(15-13-27)23-4-2-5-24-22(23)9-17-31-24/h2,4-9,11,17-18H,3,10,12-16H2,1H3
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3.20n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194794
PNG
(US9206167, 15 | USRE48059, Compound of Example 15)
Show SMILES O=C1CCc2ccc(OC\C=C\CN3CCN(CC3)c3cccc4sccc34)cc2N1
Show InChI InChI=1S/C25H27N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h1-6,8,10,17-18H,7,9,11-16H2,(H,26,29)/b2-1+
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3.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448324
PNG
(USRE48059, Compound of Example 73 | USRE48059, Com...)
Show SMILES C(COc1ccc2ncccc2c1)CN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C24H25N3OS/c1-5-23(21-9-17-29-24(21)6-1)27-14-12-26(13-15-27)11-3-16-28-20-7-8-22-19(18-20)4-2-10-25-22/h1-2,4-10,17-18H,3,11-16H2
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3.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194799
PNG
(US9206167, 20 | USRE48059, Compound of Example 20)
Show SMILES O=C1CCc2cc(OCCCCN3CCN(CC3)c3cccc4sccc34)ccc2N1
Show InChI InChI=1S/C25H29N3O2S/c29-25-9-6-19-18-20(7-8-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-5,7-8,10,17-18H,1-2,6,9,11-16H2,(H,26,29)
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3.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448336
PNG
(USRE48059, Compound of Example 122)
Show SMILES O=C1CCc2c(CCCN3CCN(CC3)c3cccc4sccc34)cccc2N1
Show InChI InChI=1S/C24H27N3OS/c28-24-10-9-19-18(4-1-6-21(19)25-24)5-3-12-26-13-15-27(16-14-26)22-7-2-8-23-20(22)11-17-29-23/h1-2,4,6-8,11,17H,3,5,9-10,12-16H2,(H,25,28)
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3.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194775
PNG
(US9206167, 184 | USRE48059, Compound of Example 11...)
Show SMILES Fc1cc(OCCCCN2CCN(CC2)c2cccc3sccc23)cc2ccc(=O)[nH]c12
Show InChI InChI=1S/C25H26FN3O2S/c26-21-17-19(16-18-6-7-24(30)27-25(18)21)31-14-2-1-9-28-10-12-29(13-11-28)22-4-3-5-23-20(22)8-15-32-23/h3-8,15-17H,1-2,9-14H2,(H,27,30)
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3.40n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194805
PNG
(US9206167, 26 | USRE48059, Compound of Example 26)
Show SMILES CN1CCc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc2C1=O
Show InChI InChI=1S/C25H29N3O2S/c1-26-11-8-19-18-20(6-7-21(19)25(26)29)30-16-3-10-27-12-14-28(15-13-27)23-4-2-5-24-22(23)9-17-31-24/h2,4-7,9,17-18H,3,8,10-16H2,1H3
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3.5n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194775
PNG
(US9206167, 184 | USRE48059, Compound of Example 11...)
Show SMILES Fc1cc(OCCCCN2CCN(CC2)c2cccc3sccc23)cc2ccc(=O)[nH]c12
Show InChI InChI=1S/C25H26FN3O2S/c26-21-17-19(16-18-6-7-24(30)27-25(18)21)31-14-2-1-9-28-10-12-29(13-11-28)22-4-3-5-23-20(22)8-15-32-23/h3-8,15-17H,1-2,9-14H2,(H,27,30)
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3.5n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194801
PNG
(US9206167, 22 | USRE48059, Compound of Example 22)
Show SMILES O=C1CCc2ccccc2N1CCCCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C26H31N3OS/c30-26-12-11-21-7-2-3-8-23(21)29(26)15-5-1-4-14-27-16-18-28(19-17-27)24-9-6-10-25-22(24)13-20-31-25/h2-3,6-10,13,20H,1,4-5,11-12,14-19H2
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4n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194786
PNG
(US9206167, 7 | USRE48059, Compound of Example 7)
Show SMILES O=c1ccc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2[nH]1
Show InChI InChI=1S/C24H25N3O2S/c28-24-8-6-18-5-7-19(17-21(18)25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-20(22)9-16-30-23/h1,3-9,16-17H,2,10-15H2,(H,25,28)
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4n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448324
PNG
(USRE48059, Compound of Example 73 | USRE48059, Com...)
Show SMILES C(COc1ccc2ncccc2c1)CN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C24H25N3OS/c1-5-23(21-9-17-29-24(21)6-1)27-14-12-26(13-15-27)11-3-16-28-20-7-8-22-19(18-20)4-2-10-25-22/h1-2,4-10,17-18H,3,11-16H2
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4n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448338
PNG
(USRE48059, Compound of Example 139)
Show SMILES OCc1cc2CCC(=C)Nc2cc1CCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C26H31N3OS/c1-19-7-8-21-16-22(18-30)20(17-24(21)27-19)4-3-10-28-11-13-29(14-12-28)25-5-2-6-26-23(25)9-15-31-26/h2,5-6,9,15-17,27,30H,1,3-4,7-8,10-14,18H2
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4n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194806
PNG
(US9206167, 27 | USRE48059, Compound of Example 27)
Show SMILES CCN1CCc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc2C1=O
Show InChI InChI=1S/C26H31N3O2S/c1-2-28-12-9-20-19-21(7-8-22(20)26(28)30)31-17-4-11-27-13-15-29(16-14-27)24-5-3-6-25-23(24)10-18-32-25/h3,5-8,10,18-19H,2,4,9,11-17H2,1H3
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4.10n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448333
PNG
(USRE48059, Compound of Example 116)
Show SMILES Cc1c(OCCCCN2CCN(CC2)c2cccc3sccc23)ccc2CCC(=O)Nc12
Show InChI InChI=1S/C26H31N3O2S/c1-19-23(9-7-20-8-10-25(30)27-26(19)20)31-17-3-2-12-28-13-15-29(16-14-28)22-5-4-6-24-21(22)11-18-32-24/h4-7,9,11,18H,2-3,8,10,12-17H2,1H3,(H,27,30)
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4.20n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448342
PNG
(USRE48059, Compound of Example 184)
Show SMILES Fc1cc(CCCN2CCN(CC2)c2cccc3sccc23)cc2CCC(=O)Nc12
Show InChI InChI=1S/C24H26FN3OS/c25-20-16-17(15-18-6-7-23(29)26-24(18)20)3-2-9-27-10-12-28(13-11-27)21-4-1-5-22-19(21)8-14-30-22/h1,4-5,8,14-16H,2-3,6-7,9-13H2,(H,26,29)
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4.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194805
PNG
(US9206167, 26 | USRE48059, Compound of Example 26)
Show SMILES CN1CCc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc2C1=O
Show InChI InChI=1S/C25H29N3O2S/c1-26-11-8-19-18-20(6-7-21(19)25(26)29)30-16-3-10-27-12-14-28(15-13-27)23-4-2-5-24-22(23)9-17-31-24/h2,4-7,9,17-18H,3,8,10-16H2,1H3
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4.40n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448333
PNG
(USRE48059, Compound of Example 116)
Show SMILES Cc1c(OCCCCN2CCN(CC2)c2cccc3sccc23)ccc2CCC(=O)Nc12
Show InChI InChI=1S/C26H31N3O2S/c1-19-23(9-7-20-8-10-25(30)27-26(19)20)31-17-3-2-12-28-13-15-29(16-14-28)22-5-4-6-24-21(22)11-18-32-24/h4-7,9,11,18H,2-3,8,10,12-17H2,1H3,(H,27,30)
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4.5n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194809
PNG
(US9206167, 31 | USRE48059, Compound of Example 31)
Show SMILES CCN1CCc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2C1=O
Show InChI InChI=1S/C26H31N3O2S/c1-2-28-12-9-20-7-8-21(19-23(20)26(28)30)31-17-4-11-27-13-15-29(16-14-27)24-5-3-6-25-22(24)10-18-32-25/h3,5-8,10,18-19H,2,4,9,11-17H2,1H3
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4.5n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194804
PNG
(US9206167, 25 | USRE48059, Compound of Example 25)
Show SMILES O=C1NCCc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc12
Show InChI InChI=1S/C24H27N3O2S/c28-24-20-6-5-19(17-18(20)7-9-25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-21(22)8-16-30-23/h1,3-6,8,16-17H,2,7,9-15H2,(H,25,28)
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4.60n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448334
PNG
(USRE48059, Compound of Example 117)
Show SMILES Cc1cccc2cc(OCCCCN3CCN(CC3)c3cccc4sccc34)c(=O)nc12
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4.70n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM448325
PNG
(USRE48059, Compound of Example 79)
Show SMILES CC(=O)n1cccc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc12
PDB

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4.70n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194818
PNG
(US9206167, 40 | USRE48059, Compound of Example 40)
Show SMILES O=c1[nH]ccc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc12
Show InChI InChI=1S/C24H25N3O2S/c28-24-20-6-5-19(17-18(20)7-9-25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-21(22)8-16-30-23/h1,3-9,16-17H,2,10-15H2,(H,25,28)
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4.80n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194783
PNG
(US9206167, 4 | USRE48059, Compound of Example 4)
Show SMILES Cc1cc(=O)[nH]c2cc(OCCCCN3CCN(CC3)c3cccc4sccc34)ccc12
Show InChI InChI=1S/C26H29N3O2S/c1-19-17-26(30)27-23-18-20(7-8-21(19)23)31-15-3-2-10-28-11-13-29(14-12-28)24-5-4-6-25-22(24)9-16-32-25/h4-9,16-18H,2-3,10-15H2,1H3,(H,27,30)
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4.90n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194806
PNG
(US9206167, 27 | USRE48059, Compound of Example 27)
Show SMILES CCN1CCc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc2C1=O
Show InChI InChI=1S/C26H31N3O2S/c1-2-28-12-9-20-19-21(7-8-22(20)26(28)30)31-17-4-11-27-13-15-29(16-14-27)24-5-3-6-25-23(24)10-18-32-25/h3,5-8,10,18-19H,2,4,9,11-17H2,1H3
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4.90n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448343
PNG
(USRE48059, Compound of Example 185)
Show SMILES Cc1cc(=O)[nH]c2cccc(CCCN3CCN(CC3)c3cccc4sccc34)c12
Show InChI InChI=1S/C25H27N3OS/c1-18-17-24(29)26-21-7-2-5-19(25(18)21)6-4-11-27-12-14-28(15-13-27)22-8-3-9-23-20(22)10-16-30-23/h2-3,5,7-10,16-17H,4,6,11-15H2,1H3,(H,26,29)
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5n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Rattus norvegicus (rat))
BDBM194803
PNG
(US9206167, 24 | USRE48059, Compound of Example 24)
Show SMILES O=C1N(CCCCCN2CCN(CC2)c2cccc3sccc23)CCc2ccccc12
Show InChI InChI=1S/C26H31N3OS/c30-26-22-8-3-2-7-21(22)11-15-29(26)14-5-1-4-13-27-16-18-28(19-17-27)24-9-6-10-25-23(24)12-20-31-25/h2-3,6-10,12,20H,1,4-5,11,13-19H2
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5n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
Dopamine D2: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-raclopride (final concentration 1 to 2 nM)...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194818
PNG
(US9206167, 40 | USRE48059, Compound of Example 40)
Show SMILES O=c1[nH]ccc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc12
Show InChI InChI=1S/C24H25N3O2S/c28-24-20-6-5-19(17-18(20)7-9-25-24)29-15-2-10-26-11-13-27(14-12-26)22-3-1-4-23-21(22)8-16-30-23/h1,3-9,16-17H,2,10-15H2,(H,25,28)
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5.10n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448330
PNG
(USRE48059, Compound of Example 90)
Show SMILES CC(=O)N1CCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2C1
Show InChI InChI=1S/C27H33N3O2S/c1-21(31)30-12-9-22-7-8-24(19-23(22)20-30)32-17-3-2-11-28-13-15-29(16-14-28)26-5-4-6-27-25(26)10-18-33-27/h4-8,10,18-19H,2-3,9,11-17,20H2,1H3
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5.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448325
PNG
(USRE48059, Compound of Example 79)
Show SMILES CC(=O)n1cccc2cc(OCCCN3CCN(CC3)c3cccc4sccc34)ccc12
PDB

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5.5n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448332
PNG
(USRE48059, Compound of Example 92)
Show SMILES CN1CCc2cc(F)c(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2C1=O
Show InChI InChI=1S/C26H30FN3O2S/c1-28-10-7-19-17-22(27)24(18-21(19)26(28)31)32-15-3-2-9-29-11-13-30(14-12-29)23-5-4-6-25-20(23)8-16-33-25/h4-6,8,16-18H,2-3,7,9-15H2,1H3
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5.70n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194790
PNG
(US9206167, 11 | US9206167, 12 | USRE48059, Compoun...)
Show SMILES O=C1CCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2N1
Show InChI InChI=1S/C25H29N3O2S/c29-25-9-7-19-6-8-20(18-22(19)26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)10-17-31-24/h3-6,8,10,17-18H,1-2,7,9,11-16H2,(H,26,29)
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5.70n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448323
PNG
(USRE48059, Compound of Example 69)
Show SMILES CC1CN(CCN1CCCCOc1ccc2[nH]c(=O)ccc2c1)c1cccc2sccc12
PDB

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6.10n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448345
PNG
(USRE48059, Compound of Example 188)
Show SMILES O=c1ccc2c(CCCN3CCN(CC3)c3cccc4sccc34)cccc2[nH]1
Show InChI InChI=1S/C24H25N3OS/c28-24-10-9-19-18(4-1-6-21(19)25-24)5-3-12-26-13-15-27(16-14-26)22-7-2-8-23-20(22)11-17-29-23/h1-2,4,6-11,17H,3,5,12-16H2,(H,25,28)
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6.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448337
PNG
(USRE48059, Compound of Example 128)
Show SMILES CC(=O)Oc1ccc(CCCN2CCN(CC2)c2cccc3sccc23)c2NC(=O)CCc12
Show InChI InChI=1S/C26H29N3O3S/c1-18(30)32-23-9-7-19(26-21(23)8-10-25(31)27-26)4-3-12-28-13-15-29(16-14-28)22-5-2-6-24-20(22)11-17-33-24/h2,5-7,9,11,17H,3-4,8,10,12-16H2,1H3,(H,27,31)
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6.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194784
PNG
(US9206167, 5 | USRE48059, Compound of Example 5)
Show SMILES Cc1cc2ccc(OCCCN3CCN(CC3)c3cccc4sccc34)cc2[nH]c1=O
Show InChI InChI=1S/C25H27N3O2S/c1-18-16-19-6-7-20(17-22(19)26-25(18)29)30-14-3-9-27-10-12-28(13-11-27)23-4-2-5-24-21(23)8-15-31-24/h2,4-8,15-17H,3,9-14H2,1H3,(H,26,29)
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6.40n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448331
PNG
(USRE48059, Compound of Example 91)
Show SMILES Fc1cc2CCNC(=O)c2cc1OCCCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C25H28FN3O2S/c26-21-16-18-6-8-27-25(30)20(18)17-23(21)31-14-2-1-9-28-10-12-29(13-11-28)22-4-3-5-24-19(22)7-15-32-24/h3-5,7,15-17H,1-2,6,8-14H2,(H,27,30)
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6.5n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194811
PNG
(US9206167, 33 | USRE48059, Compound of Example 33)
Show SMILES O=C1NCCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc12
Show InChI InChI=1S/C25H29N3O2S/c29-25-22-18-20(7-6-19(22)8-10-26-25)30-16-2-1-11-27-12-14-28(15-13-27)23-4-3-5-24-21(23)9-17-31-24/h3-7,9,17-18H,1-2,8,10-16H2,(H,26,29)
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6.60n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194795
PNG
(US9206167, 16 | USRE48059, Compound of Example 16)
Show SMILES CC1CC(=O)Nc2cc(OCCCCN3CCN(CC3)c3cccc4sccc34)ccc12
Show InChI InChI=1S/C26H31N3O2S/c1-19-17-26(30)27-23-18-20(7-8-21(19)23)31-15-3-2-10-28-11-13-29(14-12-28)24-5-4-6-25-22(24)9-16-32-25/h4-9,16,18-19H,2-3,10-15,17H2,1H3,(H,27,30)
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7n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448322
PNG
(USRE48059, Compound of Example 68)
Show SMILES CC1CN(CCN1CCCCOc1ccc2nc(=O)ccc2c1)c1cccc2sccc12
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7n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194816
PNG
(US9206167, 38 | USRE48059, Compound of Example 38)
Show SMILES COc1ccc2ccn(CCCCN3CCN(CC3)c3cccc4sccc34)c(=O)c2c1
Show InChI InChI=1S/C26H29N3O2S/c1-31-21-8-7-20-9-13-29(26(30)23(20)19-21)12-3-2-11-27-14-16-28(17-15-27)24-5-4-6-25-22(24)10-18-32-25/h4-10,13,18-19H,2-3,11-12,14-17H2,1H3
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7.30n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448341
PNG
(USRE48059, Compound of Example 163)
Show SMILES Clc1cc2CCC(=C)Nc2c(Cl)c1CCCN1CCN(CC1)c1cccc2sccc12
Show InChI InChI=1S/C25H27Cl2N3S/c1-17-7-8-18-16-21(26)19(24(27)25(18)28-17)4-3-10-29-11-13-30(14-12-29)22-5-2-6-23-20(22)9-15-31-23/h2,5-6,9,15-16,28H,1,3-4,7-8,10-14H2
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7.40n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194797
PNG
(US9206167, 18 | USRE48059, Compound of Example 18)
Show SMILES CN1C(=O)CCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc12
Show InChI InChI=1S/C26H31N3O2S/c1-27-24-19-21(9-7-20(24)8-10-26(27)30)31-17-3-2-12-28-13-15-29(16-14-28)23-5-4-6-25-22(23)11-18-32-25/h4-7,9,11,18-19H,2-3,8,10,12-17H2,1H3
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8n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448321
PNG
(USRE48059, Compound of Example 64)
Show SMILES CC1CN(CCN1CCCOc1ccc2nc(=O)ccc2c1)c1cccc2sccc12
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8.20n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM194810
PNG
(US9206167, 32 | USRE48059, Compound of Example 32)
Show SMILES CN1CCc2ccc(OCCCCN3CCN(CC3)c3cccc4sccc34)cc2C1=O
Show InChI InChI=1S/C26H31N3O2S/c1-27-12-9-20-7-8-21(19-23(20)26(27)30)31-17-3-2-11-28-13-15-29(16-14-28)24-5-4-6-25-22(24)10-18-32-25/h4-8,10,18-19H,2-3,9,11-17H2,1H3
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8.60n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 2A


(Rattus norvegicus (rat))
BDBM448344
PNG
(USRE48059, Compound of Example 186)
Show SMILES O=C1CCc2cccc(CCCN3CCN(CC3)c3cccc4sccc34)c2N1
Show InChI InChI=1S/C24H27N3OS/c28-23-10-9-19-5-1-4-18(24(19)25-23)6-3-12-26-13-15-27(16-14-26)21-7-2-8-22-20(21)11-17-29-22/h1-2,4-5,7-8,11,17H,3,6,9-10,12-16H2,(H,25,28)
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8.80n/an/an/an/an/an/an/an/a



Otsuka Pharmaceutical Co., Ltd.

US Patent


Assay Description
5-HT2A: The binding assay was performed using 40 μl of the membrane specimen, 20 μl of [3H]-Ketanserin (final concentration 1 to 3 nM), 20 ...


US Patent USRE48059 (2020)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%