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| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Cyclin-dependent kinase 2 (298/298 = 100%)† (Homo sapiens (Human)) | BDBM7615 (2,4-bis anilino pyrimidine deriv. 11 | 4-N-(2,5-di...) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Rational Discovery LLC Curated by ChEMBL | Assay Description Inhibition of Cyclin-dependent kinase 2 | J Med Chem 48: 3313-8 (2005) Article DOI: 10.1021/jm049066l BindingDB Entry DOI: 10.7270/Q2F76DC7 | |||||||||||
| More data for this Ligand-Target Pair |  3D Structure (crystal) | ||||||||||||
| CDK2/CycE (298/298 = 100%)† (Homo sapiens (Human)) | BDBM7615 (2,4-bis anilino pyrimidine deriv. 11 | 4-N-(2,5-di...) | PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca | Assay Description The kinase activity was assayed using an in vitro scintillation proximity assay (SPA) for measuring incorporation of [gamma-33P] ATP into GST-Rb. | Bioorg Med Chem Lett 13: 2961-6 (2003) Article DOI: 10.1016/s0960-894x(03)00203-8 BindingDB Entry DOI: 10.7270/Q29S1P8K | |||||||||||
| More data for this Ligand-Target Pair | 3D Structure (crystal) | ||||||||||||
