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Found 3 Enz. Inhib. hit(s) for PDB: 1ITO
TargetCathepsin B(Homo sapiens (Human))
National Chemical Laboratory (Csir-Ncl)

Curated by ChEMBL
LigandPNGBDBM16510((2S,3S)-3-[[(1S)-1-(isoamylcarbamoyl)-3-methyl-but...)
Affinity DataKi:  3.36nMAssay Description:Inhibition of cathepsin BMore data for this Ligand-Target Pair
TargetCathepsin B(Homo sapiens (Human))
National Chemical Laboratory (Csir-Ncl)

Curated by ChEMBL
LigandPNGBDBM16510((2S,3S)-3-[[(1S)-1-(isoamylcarbamoyl)-3-methyl-but...)
Affinity DataIC50:  1.53nMpH: 6.8 T: 2°CAssay Description:Screening Center: Penn Center for Molecular Discovery Center Affiliation: University of Pennsylvania Network: Molecular Library Screening Center Netw...More data for this Ligand-Target Pair
TargetCathepsin B(Bos taurus (bovine))
Osaka University Of Pharmaceutical Sciences

LigandPNGBDBM16510((2S,3S)-3-[[(1S)-1-(isoamylcarbamoyl)-3-methyl-but...)
Affinity DataIC50:  40nMpH: 6.0 T: 2°CAssay Description:Inhibitory activities (IC50, concentration of 50% inhibition) of compounds for bovine CB in vitro were determined by monitoring the cleavage of fluor...More data for this Ligand-Target Pair