Affinity Data by PDB ID

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PDB code 1L5Q

Identical Ligands in BindingDB

Found 3 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Glycogen Phosphorylase (PYGL) (847/847 = 100%)^† (Homo sapiens (human))	BDBM50136446 (1-{(S)-2-[(5-Chloro-1H-indole-2-carbonyl)-amino]-3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	7.2	22
Pfizer Inc					Assay Description Human liver glycogen phsphorylase (HLGP) activity was measured in the direction of glycogen synthesis by the release of phosphate from glucose-1-phos...				Chem Biol 7: 677-82 (2000) Article DOI: 10.1016/S1074-5521(00)00004-1 BindingDB Entry DOI: 10.7270/Q2H41PT2
Pfizer Inc					More data for this Ligand-Target Pair				3D Structure (crystal)
Glycogen Phosphorylase (PYGL) (847/847 = 100%)^† (Homo sapiens (human))	BDBM50136446 (1-{(S)-2-[(5-Chloro-1H-indole-2-carbonyl)-amino]-3...) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet	CHEMBL DrugBank MMDB PC cid PC sid PDB UniChem Similars	MMDB PDB Article PubMed	n/a	n/a	45	n/a	n/a	n/a	n/a	n/a	n/a
Merck Research Laboratories Curated by ChEMBL					Assay Description Inhibitory concentration against recombinant human liver glycogen phosphorylase a (HLGPa)				Bioorg Med Chem Lett 13: 4385-8 (2003) Article DOI: 10.1016/j.bmcl.2003.09.022 BindingDB Entry DOI: 10.7270/Q2S75FQV
Merck Research Laboratories Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)
Liver glycogen phosphorylase (803/848 = 95%)^† (Rattus norvegicus)	BDBM10849 (1,3,7-trimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-d...) Show SMILES Cn1cnc2n(C)c(=O)n(C)c(=O)c12 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet	Purchase CHEMBL DrugBank KEGG MMDB PC cid PC sid PDB UniChem Patents Similars	PDB Article PubMed	n/a	n/a	6.48E+5	n/a	n/a	n/a	n/a	n/a	n/a
China Pharmaceutical University Curated by ChEMBL					Assay Description Inhibitory concentration against rat liver glycogen phosphorylase				Bioorg Med Chem Lett 15: 4944-8 (2005) Article DOI: 10.1016/j.bmcl.2005.08.026 BindingDB Entry DOI: 10.7270/Q27M08R5
China Pharmaceutical University Curated by ChEMBL					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output