Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Betaine--homocysteine S-methyltransferase 1 (399/406 = 98%)† (Homo sapiens (Human)) | BDBM50189917![]() ((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | 12 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Binding affinity to human recombinant BHMT expressed in Escherichia coli using variable levels of betaine substrate by Dixon plot | J Med Chem 52: 3652-65 (2009) Article DOI: 10.1021/jm8015798 BindingDB Entry DOI: 10.7270/Q2ZG6S55 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Betaine--homocysteine S-methyltransferase 1 (399/406 = 98%)† (Homo sapiens (Human)) | BDBM50189917![]() ((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Inhibition of human BHMT | J Med Chem 49: 3982-9 (2006) Article DOI: 10.1021/jm050885v BindingDB Entry DOI: 10.7270/Q2S75FXJ | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Betaine--homocysteine S-methyltransferase 1 (399/406 = 98%)† (Homo sapiens (Human)) | BDBM50189917![]() ((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 93 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Inhibition of human recombinant BHMT using N-methyl-[14C]-betaine/D,L-homocysteine as substrate after 30 mins by scintiillation counting analysis | Eur J Med Chem 65: 256-75 (2013) Article DOI: 10.1016/j.ejmech.2013.04.039 BindingDB Entry DOI: 10.7270/Q2028SZD | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Betaine--homocysteine S-methyltransferase 1 (399/406 = 98%)† (Homo sapiens (Human)) | BDBM50189917![]() ((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | 138 | n/a | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Inhibition of human recombinant BHMT expressed in Escherichia coli using 2 mM betaine and 1 mM DL-homocysteine as substrate | J Med Chem 52: 3652-65 (2009) Article DOI: 10.1021/jm8015798 BindingDB Entry DOI: 10.7270/Q2ZG6S55 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
Betaine--homocysteine S-methyltransferase 1 (399/406 = 98%)† (Homo sapiens (Human)) | BDBM50189917![]() ((R,S)-5-(3-amino-3-carboxy-propylsulfanyl)-pentano...) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar | CHEMBL PC cid PC sid PDB UniChem Similars | PDB Article PubMed | n/a | n/a | n/a | 280 | n/a | n/a | n/a | n/a | n/a |
Academy of Sciences of the Czech Republic Curated by ChEMBL | Assay Description Binding affinity to human recombinant BHMT expressed in Escherichia coli by intrinsic tryptophan fluorescence studies | J Med Chem 52: 3652-65 (2009) Article DOI: 10.1021/jm8015798 BindingDB Entry DOI: 10.7270/Q2ZG6S55 | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |