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Report error Found 9 Enz. Inhib. hit(s) for PDB: 1PXO
TargetCyclin-dependent kinase 2(Human)
Cyclacel

LigandPNGBDBM8061(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32 | 4...)
Affinity DataKi: <1nMAssay Description:Kinase assay using cyclin-dependant kinases (CDK).More data for this Ligand-Target Pair
LigandPNGBDBM8061(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32 | 4...)
Affinity DataKi:  2nM ΔG°:  -50.5kJ/moleT: 30°CAssay Description:In vitro kinase assay using purified enzyme, was incubated at 30 °C with substrate, and test compounds in the presence of 100 uM ATP/ [gamma-32P...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Human)
Cyclacel

LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  2nMAssay Description:Inhibition of CDK2More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Human)
Cyclacel

LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  2nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Human)
Cyclacel

LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataKi:  396nMAssay Description:Inhibition of CDK2 (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataIC50:  10nMAssay Description:Inhibition of His-tagged CDK2/cyclin E (unknown origin) expressed in Baculovirus infected Sf9 cells using histone H1 as substrate in presence of [gam...More data for this Ligand-Target Pair
TargetCyclin-dependent kinase 2(Human)
Cyclacel

LigandPNGBDBM8061(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32 | 4...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.More data for this Ligand-Target Pair
LigandPNGBDBM8061(2-Anilino-4-(thiazol-5-yl)pyrimidine deriv. 32 | 4...)
Affinity DataIC50:  10nMAssay Description:In vitro inhibition assay using human recombinant CDK2 and human recombinant cyclin A2.More data for this Ligand-Target Pair
LigandPNGBDBM50229973((4-(2-Amino-4-methylthiazol-5-yl)pyrimidin-2-yl)-(...)
Affinity DataIC50:  4.40E+3nMAssay Description:Inhibition of GST-tagged CDK2/cyclin A2 (unknown origin) expressed in Escherichia coli using histone H1 as substrate in presence of [gamma-33P]-ATP b...More data for this Ligand-Target Pair