Affinity Data by PDB ID

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PDB code 1SQK

Identical Ligands in BindingDB

Found 3 hits Enzyme Inhibition Constant Data
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
ACT1 (R335K) (324/374 = 87%)^† (Baker's yeast)	BDBM65515 (76343-93-6 \| LAT-A \| LatA \| Latrunculin A) Show SMILES Show InChI	PDB GoogleScholar	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	40	n/a	n/a	n/a	n/a	n/a	30
Novartis Pharma AG					Assay Description Saturated ACT1 wild type (WT) as well as engineered ACT1 R183K (R183K) and ACT1 R335K (R335K) cultures were adjusted to 10 OD600 and 3 uL of serial 1...				ACS Chem Biol 12: 2264-2269 (2017) Article DOI: 10.1021/acschembio.7b00385 BindingDB Entry DOI: 10.7270/Q25B00MP
Novartis Pharma AG					More data for this Ligand-Target Pair				3D Structure (crystal)
ACT1 (325/374 = 87%)^† (Baker's yeast)	BDBM65515 (76343-93-6 \| LAT-A \| LatA \| Latrunculin A) Show SMILES Show InChI	PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	70	n/a	n/a	n/a	n/a	n/a	30
Novartis Pharma AG					Assay Description Saturated ACT1 wild type (WT) as well as engineered ACT1 R183K (R183K) and ACT1 R335K (R335K) cultures were adjusted to 10 OD600 and 3 uL of serial 1...				ACS Chem Biol 12: 2264-2269 (2017) Article DOI: 10.1021/acschembio.7b00385 BindingDB Entry DOI: 10.7270/Q25B00MP
Novartis Pharma AG					More data for this Ligand-Target Pair				3D Structure (crystal)
ACT1 (R183K) (324/374 = 87%)^† (Baker's yeast)	BDBM65515 (76343-93-6 \| LAT-A \| LatA \| Latrunculin A) Show SMILES Show InChI	PDB GoogleScholar	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	110	n/a	n/a	n/a	n/a	n/a	30
Novartis Pharma AG					Assay Description Saturated ACT1 wild type (WT) as well as engineered ACT1 R183K (R183K) and ACT1 R335K (R335K) cultures were adjusted to 10 OD600 and 3 uL of serial 1...				ACS Chem Biol 12: 2264-2269 (2017) Article DOI: 10.1021/acschembio.7b00385 BindingDB Entry DOI: 10.7270/Q25B00MP
Novartis Pharma AG					More data for this Ligand-Target Pair				3D Structure (crystal)

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_* indicates data uncertainty>20%
* 0.9 Tanimoto similarity
† Identities from BLAST output