Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ACT1 (R335K) (324/374 = 87%)† (Baker's yeast) | BDBM65515![]() (76343-93-6 | LAT-A | LatA | Latrunculin A) | PDB GoogleScholar | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 40 | n/a | n/a | n/a | n/a | n/a | 30 |
Novartis Pharma AG | Assay Description Saturated ACT1 wild type (WT) as well as engineered ACT1 R183K (R183K) and ACT1 R335K (R335K) cultures were adjusted to 10 OD600 and 3 uL of serial 1... | ACS Chem Biol 12: 2264-2269 (2017) Article DOI: 10.1021/acschembio.7b00385 BindingDB Entry DOI: 10.7270/Q25B00MP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ACT1 (325/374 = 87%)† (Baker's yeast) | BDBM65515![]() (76343-93-6 | LAT-A | LatA | Latrunculin A) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | 30 |
Novartis Pharma AG | Assay Description Saturated ACT1 wild type (WT) as well as engineered ACT1 R183K (R183K) and ACT1 R335K (R335K) cultures were adjusted to 10 OD600 and 3 uL of serial 1... | ACS Chem Biol 12: 2264-2269 (2017) Article DOI: 10.1021/acschembio.7b00385 BindingDB Entry DOI: 10.7270/Q25B00MP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) | ||||||||||||
ACT1 (R183K) (324/374 = 87%)† (Baker's yeast) | BDBM65515![]() (76343-93-6 | LAT-A | LatA | Latrunculin A) | PDB GoogleScholar | PC cid PC sid PDB UniChem | PDB Article PubMed | n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | 30 |
Novartis Pharma AG | Assay Description Saturated ACT1 wild type (WT) as well as engineered ACT1 R183K (R183K) and ACT1 R335K (R335K) cultures were adjusted to 10 OD600 and 3 uL of serial 1... | ACS Chem Biol 12: 2264-2269 (2017) Article DOI: 10.1021/acschembio.7b00385 BindingDB Entry DOI: 10.7270/Q25B00MP | |||||||||||
More data for this Ligand-Target Pair | ![]() 3D Structure (crystal) |